ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactI0296 check: MH O KOG0724 Posttranslational modification, protein turnover, chaperones Zuotin and related molecular chaperones (DnaJ superfamily), contains DNA-binding domains
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactI0296 103746 104576 277
(277 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YFR041c [O] KOG0724 Zuotin and related molecular chaperones (Dna... 261 8e-70
SPAC2E1P5.03 [O] KOG0724 Zuotin and related molecular chaperones... 114 2e-25
7293551 [O] KOG0724 Zuotin and related molecular chaperones (Dna... 61 2e-09
Hs21361912 [O] KOG0724 Zuotin and related molecular chaperones (... 60 4e-09
Hs4827026 [O] KOG0715 Molecular chaperone (DnaJ superfamily) 57 3e-08
SPCC830.07c [O] KOG0714 Molecular chaperone (DnaJ superfamily) 57 4e-08
7298006 [O] KOG0712 Molecular chaperone (DnaJ superfamily) 56 5e-08
CE01057 [O] KOG0713 Molecular chaperone (DnaJ superfamily) 54 2e-07
Hs22044388_1 [O] KOG0713 Molecular chaperone (DnaJ superfamily) 54 2e-07
7296101 [O] KOG0714 Molecular chaperone (DnaJ superfamily) 54 3e-07
SPBC1734.11 [O] KOG0712 Molecular chaperone (DnaJ superfamily) 51 2e-06
At3g08970 [O] KOG0714 Molecular chaperone (DnaJ superfamily) 50 3e-06
7296533 [O] KOG0716 Molecular chaperone (DnaJ superfamily) 50 3e-06
7296532 [O] KOG0716 Molecular chaperone (DnaJ superfamily) 50 3e-06
YMR161w [O] KOG0714 Molecular chaperone (DnaJ superfamily) 49 6e-06
SPAC6B12.08 [O] KOG0717 Molecular chaperone (DnaJ superfamily) 49 6e-06
SPBC1347.05c [O] KOG0712 Molecular chaperone (DnaJ superfamily) 49 8e-06
>YFR041c [O] KOG0724 Zuotin and related molecular chaperones (DnaJ
superfamily) contains DNA-binding domains
Length = 295
Score = 261 bits (667), Expect = 8e-70
Identities = 117/238 (49%), Positives = 169/238 (70%)
Query: 11 ALFLSLFAAVAYCFTRDEIEIFQLQQELHTKYGSNMDFYQFLKLPKLKQSTSAEITKNFK 70
AL + +++Y FT E EIFQLQ E+ TKYG +M+FY+FLKLPKL+ S++ EITKN +
Sbjct: 8 ALVVLGLVSLSYAFTTIETEIFQLQNEISTKYGPDMNFYKFLKLPKLQNSSTKEITKNLR 67
Query: 71 KLAKKYHPDKNPKYRKLYERINLITKLLSDEGHRKTYDYYLKNGFPKYDYKKGGFFFNRV 130
KL+KKYHPDKNPKYRKLYER+NL T++LS+ +RK YDYYL+NGFP YD+ KGGF+F+R+
Sbjct: 68 KLSKKYHPDKNPKYRKLYERLNLATQILSNSSNRKIYDYYLQNGFPNYDFHKGGFYFSRM 127
Query: 131 TPSVWFTFFFLYVLAGVIHLVLLKLHNNANKKRIENFVAKVREQDTTNSLGESKLVFKES 190
P WF F++++ + ++ + + + RIENF+++ ++QD TN LG +L FK+
Sbjct: 128 KPKTWFLLAFIWIVVNIGQYIISIIQYRSQRSRIENFISQCKQQDDTNGLGVKQLTFKQH 187
Query: 191 EDSEDKQLLVRFGEVFVIQPDESLAKISTDDIIDPGINDTLLVKLPKWIWNKTLGKFI 248
E E K L+VRF +V+V++PD S IS D + P + + L ++P +WN T GK +
Sbjct: 188 EKDEGKSLVVRFSDVYVVEPDGSETLISPDTLDKPSVKNCLFWRIPASVWNMTFGKSV 245
>SPAC2E1P5.03 [O] KOG0724 Zuotin and related molecular chaperones (DnaJ
superfamily) contains DNA-binding domains
Length = 303
Score = 114 bits (285), Expect = 2e-25
Identities = 67/231 (29%), Positives = 123/231 (53%), Gaps = 7/231 (3%)
Query: 14 LSLFAAVAYCFTRDEIEIFQLQQELHTKYGSNMDFYQFLKLPKLKQSTSAEITKNFKKLA 73
L L V +T ++EIF++ L + + FY+ L++P +++ EI + ++K +
Sbjct: 7 LLLLFGVCLAWTSSDLEIFRVVDSLKSILKNKATFYELLEVPT--KASIKEINRAYRKKS 64
Query: 74 KKYHPDKNPKYRKLYERINLITKLLSDEGHRKTYDYYLKNGFPKYDYKKGGFFFNRVTPS 133
YHPDKNPK ++LY + LI +L + RK YDY+LKNGFP+ +K G+ ++R P
Sbjct: 65 ILYHPDKNPKSKELYTLLGLIVNILRNTETRKRYDYFLKNGFPR--WKGTGYLYSRYRPG 122
Query: 134 VWFTFFFLYVLAGVIHLVLLKLHNNANKKRIENFVAKVREQDT-TNSLGESKLVFKESED 192
+ L++L + H V+L + + KK +++ + R+ ++ S SK + +
Sbjct: 123 LGAVLVLLFLLISIAHFVMLVISSKRQKKIMQDHIDIARQHESYATSARGSKRIVQVPGG 182
Query: 193 SEDKQLLVRFGEVFVIQPDESLA-KISTDDIIDPGINDTLLVKLPKWI-WN 241
+ G+V ++ P ++ +S D + I+DT +LP++I WN
Sbjct: 183 RRIYTVDSITGQVCILDPSSNIEYLVSPDSVASVKISDTFFYRLPRFIVWN 233
>7293551 [O] KOG0724 Zuotin and related molecular chaperones (DnaJ
superfamily) contains DNA-binding domains
Length = 522
Score = 60.8 bits (146), Expect = 2e-09
Identities = 62/252 (24%), Positives = 113/252 (44%), Gaps = 44/252 (17%)
Query: 8 VTYALFLSLFAAVAYCFTRDEIEIFQLQQELHTKYGSNMDFYQFLKLPKLKQSTSAEITK 67
+T A L L A A + +E+EIF L +E+ N +FY+F+ + + +T AE+ +
Sbjct: 7 LTLAGLLLLCATGASAWHSEELEIFDLVEEV------NRNFYEFMGINQT--ATGAEVKR 58
Query: 68 NFKKLAKKYHPDKNPKYRKLYERINLIT--KLLSDEGHRKTYDYYLKNGFPKYDYKKGGF 125
F+ L+ HPDKNP + NL++ ++L D R+ YD LK G P ++K +
Sbjct: 59 AFRTLSIVLHPDKNPAEDANIQFRNLVSIYEVLKDPSRREKYDRVLKEGMP--NWKSALY 116
Query: 126 FFNRVTPSVWFTFFFLYVLAGVIHLVLLKLHNNANKKRIENFVAKVREQDTTNSLGESKL 185
++ R+ + F+ L + L + A + ++ T + +KL
Sbjct: 117 YYRRMRKIGLYEGAFILFLITTVGQYLFA------------WAAYLEKKYTAEQVFGTKL 164
Query: 186 VFKESEDSEDKQLLVRFGEVFVIQPDESLAKISTDDIIDPGINDTLLVKLPKWIWNKTLG 245
+ ++ I D L++I P + +TL +++P +WN L
Sbjct: 165 KKLQKKNKN-------------IDMDVILSEIPM-----PSLLNTLPIQIPLALWN--LP 204
Query: 246 KFINIGTSKSQQ 257
+ I G SK+ +
Sbjct: 205 RTIKNGFSKANE 216
>Hs21361912 [O] KOG0724 Zuotin and related molecular chaperones (DnaJ
superfamily) contains DNA-binding domains
Length = 554
Score = 59.7 bits (143), Expect = 4e-09
Identities = 51/195 (26%), Positives = 102/195 (52%), Gaps = 17/195 (8%)
Query: 12 LFLSLFAAVAYC--FTRDEIEIFQLQQELHTKYGSNMDFYQFLKLPKLKQSTSAEITKNF 69
L L L AAVA + ++E+F L +E+ ++FYQFL + + ++SA+I K +
Sbjct: 34 LLLLLLAAVAPARGWESGDLELFDLVEEVQ------LNFYQFLGVQQ--DASSADIRKAY 85
Query: 70 KKLAKKYHPDKN--PKYRKLYERINLITKLLSDEGHRKTYDYYLKNGFPKYDYKKGGFFF 127
+KL+ HPDKN + ++ I ++L D+ R+ YD L NG P D+++ F++
Sbjct: 86 RKLSLTLHPDKNKDENAETQFRQLVAIYEVLKDDERRQRYDDILINGLP--DWRQPVFYY 143
Query: 128 NRVTP-SVWFTFFFLYVLAGVIHLVLLKLHNNANKKRIENFVAKVREQDTTNSLGESKLV 186
RV S L+++ V H + + + +K+++ +++ + + + +S V
Sbjct: 144 RRVRKMSNAELALLLFIILTVGHYAV--VWSIYLEKQLDELLSRKKREKKKKTGSKSVDV 201
Query: 187 FKESEDSEDKQLLVR 201
K ++++LL++
Sbjct: 202 SKLGASEKNERLLMK 216
>Hs4827026 [O] KOG0715 Molecular chaperone (DnaJ superfamily)
Length = 480
Score = 57.0 bits (136), Expect = 3e-08
Identities = 34/87 (39%), Positives = 50/87 (57%), Gaps = 11/87 (12%)
Query: 47 DFYQFLKLPKLKQSTSAEITKNFKKLAKKYHPDKN---PKYRKLYERINLITKLLSDEGH 103
D+YQ L +P+ ++ EI K + +LAKKYHPD N PK ++ + ++ ++LSDE
Sbjct: 93 DYYQILGVPR--NASQKEIKKAYYQLAKKYHPDTNKDDPKAKEKFSQLAEAYEVLSDEVK 150
Query: 104 RKTYDYYLKNGF------PKYDYKKGG 124
RK YD Y GF ++ Y KGG
Sbjct: 151 RKQYDAYGSAGFDPGASGSQHSYWKGG 177
>SPCC830.07c [O] KOG0714 Molecular chaperone (DnaJ superfamily)
Length = 379
Score = 56.6 bits (135), Expect = 4e-08
Identities = 25/52 (48%), Positives = 36/52 (69%)
Query: 59 QSTSAEITKNFKKLAKKYHPDKNPKYRKLYERINLITKLLSDEGHRKTYDYY 110
+++ AE+ K ++KLA KYHPDKNP K ++ I+L ++LSD RK YD Y
Sbjct: 16 EASEAELKKAYRKLALKYHPDKNPNGEKKFKEISLAYEVLSDPQRRKLYDQY 67
>7298006 [O] KOG0712 Molecular chaperone (DnaJ superfamily)
Length = 389
Score = 56.2 bits (134), Expect = 5e-08
Identities = 27/66 (40%), Positives = 41/66 (61%), Gaps = 2/66 (3%)
Query: 45 NMDFYQFLKLPKLKQSTSAEITKNFKKLAKKYHPDKNPKYRKLYERINLITKLLSDEGHR 104
N++ Y LK+ +T EI KN++KLAK++HPDKNP ++ I+ ++LSD R
Sbjct: 3 NLNLYDVLKVAP--DATDEEIKKNYRKLAKEFHPDKNPDAGDKFKEISFAYEVLSDPEKR 60
Query: 105 KTYDYY 110
+ YD Y
Sbjct: 61 RIYDRY 66
>CE01057 [O] KOG0713 Molecular chaperone (DnaJ superfamily)
Length = 378
Score = 54.3 bits (129), Expect = 2e-07
Identities = 27/68 (39%), Positives = 44/68 (64%), Gaps = 5/68 (7%)
Query: 44 SNMDFYQFLKLPKLKQSTSAEITKNFKKLAKKYHPDKNPK---YRKLYERINLITKLLSD 100
S MDFYQ L + K+ ++ AEI ++KLA KYHPD+NP ++ ++++++ +LSD
Sbjct: 14 SEMDFYQLLGVEKM--ASEAEIKSAYRKLALKYHPDRNPNDAHAQEEFKKVSIAYSVLSD 71
Query: 101 EGHRKTYD 108
R+ YD
Sbjct: 72 PNKRRQYD 79
>Hs22044388_1 [O] KOG0713 Molecular chaperone (DnaJ superfamily)
Length = 127
Score = 53.9 bits (128), Expect = 2e-07
Identities = 32/75 (42%), Positives = 43/75 (56%), Gaps = 5/75 (6%)
Query: 43 GSNMDFYQFLKLPKLKQSTSAEITKNFKKLAKKYHPDKNPKYRKL---YERINLITKLLS 99
G++ DFY L + K ++S EI + FKKLA K HPDKNP + +IN ++L
Sbjct: 31 GTDQDFYSLLGVSKT--ASSREIRQAFKKLALKLHPDKNPNNPNAHGDFLKINRAYEVLK 88
Query: 100 DEGHRKTYDYYLKNG 114
DE RK YD Y + G
Sbjct: 89 DEDLRKKYDKYGEKG 103
>7296101 [O] KOG0714 Molecular chaperone (DnaJ superfamily)
Length = 335
Score = 53.5 bits (127), Expect = 3e-07
Identities = 35/102 (34%), Positives = 51/102 (49%), Gaps = 10/102 (9%)
Query: 47 DFYQFLKLPKLKQSTSAEITKNFKKLAKKYHPDKN--PKYRKLYERINLITKLLSDEGHR 104
D+Y+ L LPK +T EI K ++KLA +YHPDKN ++ + ++LSD+ R
Sbjct: 4 DYYKILGLPKT--ATDDEIKKAYRKLALRYHPDKNKAANAEDKFKEVAEAYEVLSDKSKR 61
Query: 105 KTYDYYLKNGFPKYDYKKGGFFFNRVT------PSVWFTFFF 140
+ YD Y ++G + GG N T P F FF
Sbjct: 62 EVYDKYGEDGLKSGGTRNGGPSSNSFTYQFHGDPRATFAQFF 103
>SPBC1734.11 [O] KOG0712 Molecular chaperone (DnaJ superfamily)
Length = 407
Score = 51.2 bits (121), Expect = 2e-06
Identities = 23/55 (41%), Positives = 36/55 (64%)
Query: 60 STSAEITKNFKKLAKKYHPDKNPKYRKLYERINLITKLLSDEGHRKTYDYYLKNG 114
++ AE+ K ++KLA KYHPDKNP ++ I+ ++L+DE R TYD + + G
Sbjct: 17 ASQAELKKAYRKLALKYHPDKNPNAGDKFKEISRAYEILADEEKRATYDRFGEEG 71
>At3g08970 [O] KOG0714 Molecular chaperone (DnaJ superfamily)
Length = 572
Score = 50.4 bits (119), Expect = 3e-06
Identities = 34/92 (36%), Positives = 42/92 (44%), Gaps = 14/92 (15%)
Query: 58 KQSTSAEITKNFKKLAKKYHPDKNPK--YRKLYERINLITKLLSDEGHRKTYDYY----- 110
K + EI K F K + KYHPDKN ++ + IN ++LSDE RK YD Y
Sbjct: 36 KDAKQREIQKAFHKQSLKYHPDKNKDKGAQEKFAEINNAYEILSDEEKRKNYDLYGDEKG 95
Query: 111 ---LKNGFP----KYDYKKGGFFFNRVTPSVW 135
+GFP Y Y G FN P W
Sbjct: 96 QPGFDSGFPGGNGGYSYSSSGGGFNFGGPGGW 127
>7296533 [O] KOG0716 Molecular chaperone (DnaJ superfamily)
Length = 223
Score = 50.4 bits (119), Expect = 3e-06
Identities = 28/70 (40%), Positives = 38/70 (54%), Gaps = 5/70 (7%)
Query: 44 SNMDFYQFLKLPKLKQSTSAEITKNFKKLAKKYHPDKNP---KYRKLYERINLITKLLSD 100
S Y+ L LPK +T +I K ++KLA KYHPDKNP ++ +N +LSD
Sbjct: 14 SGDSLYEILGLPKT--ATGDDIKKTYRKLALKYHPDKNPDNVDAADKFKEVNRAHSILSD 71
Query: 101 EGHRKTYDYY 110
+ R YD Y
Sbjct: 72 QTKRNIYDNY 81
>7296532 [O] KOG0716 Molecular chaperone (DnaJ superfamily)
Length = 249
Score = 50.4 bits (119), Expect = 3e-06
Identities = 28/70 (40%), Positives = 38/70 (54%), Gaps = 5/70 (7%)
Query: 44 SNMDFYQFLKLPKLKQSTSAEITKNFKKLAKKYHPDKNP---KYRKLYERINLITKLLSD 100
S Y+ L LPK +T +I K ++KLA KYHPDKNP ++ +N +LSD
Sbjct: 14 SGDSLYEILGLPKT--ATGDDIKKTYRKLALKYHPDKNPDNVDAADKFKEVNRAHSILSD 71
Query: 101 EGHRKTYDYY 110
+ R YD Y
Sbjct: 72 QTKRNIYDNY 81
>YMR161w [O] KOG0714 Molecular chaperone (DnaJ superfamily)
Length = 224
Score = 49.3 bits (116), Expect = 6e-06
Identities = 27/64 (42%), Positives = 42/64 (65%), Gaps = 4/64 (6%)
Query: 47 DFYQFLKLPKLKQSTSAEITKNFKKLAKKYHPDKN--PKYRKLYERINLITKLLSDEGHR 104
+FY+ LK+ + ++T +EI K ++KLA K HPDKN PK + ++ IN ++LS+E R
Sbjct: 21 EFYEILKVDR--KATDSEIKKAYRKLAIKLHPDKNSHPKAGEAFKVINRAFEVLSNEEKR 78
Query: 105 KTYD 108
YD
Sbjct: 79 SIYD 82
>SPAC6B12.08 [O] KOG0717 Molecular chaperone (DnaJ superfamily)
Length = 380
Score = 49.3 bits (116), Expect = 6e-06
Identities = 27/75 (36%), Positives = 46/75 (61%), Gaps = 6/75 (8%)
Query: 45 NMDFYQFLKLPKLKQSTSAEITKNFKKLAKKYHPDKNP---KYRKLYERINLITKLLSDE 101
+MD Y+ L++ S EI N++KLA +YHPD+NP Y +++ +IN +LS++
Sbjct: 7 DMDCYEILQVNH--DSDLQEIKANYRKLALQYHPDRNPGIEDYNEIFSQINAAYNILSND 64
Query: 102 GHRKTYDY-YLKNGF 115
RK ++ YL+N +
Sbjct: 65 DKRKWHEKDYLRNQY 79
>SPBC1347.05c [O] KOG0712 Molecular chaperone (DnaJ superfamily)
Length = 386
Score = 48.9 bits (115), Expect = 8e-06
Identities = 29/84 (34%), Positives = 44/84 (51%), Gaps = 13/84 (15%)
Query: 58 KQSTSAEITKNFKKLAKKYHPDKNPKYRKLYER---INLITKLLSDEGHRKTYDYYLKNG 114
K ++ +EI K +++L K++HPDKNP + E+ IN ++LSD RK YD Y + G
Sbjct: 16 KDASESEIRKAYRQLTKQWHPDKNPGNEEAQEKFIEINKAHEVLSDPEQRKIYDAYGEEG 75
Query: 115 F----------PKYDYKKGGFFFN 128
P + GGF F+
Sbjct: 76 LNGQPGGPGGGPGEGFPGGGFGFD 99
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.320 0.138 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,305,270
Number of Sequences: 60738
Number of extensions: 732111
Number of successful extensions: 2536
Number of sequences better than 1.0e-05: 17
Number of HSP's better than 0.0 without gapping: 5
Number of HSP's successfully gapped in prelim test: 12
Number of HSP's that attempted gapping in prelim test: 2513
Number of HSP's gapped (non-prelim): 20
length of query: 277
length of database: 30,389,216
effective HSP length: 105
effective length of query: 172
effective length of database: 24,011,726
effective search space: 4130016872
effective search space used: 4130016872
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)