ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactI0320 good H KOG1370 Coenzyme transport and metabolism S-adenosylhomocysteine hydrolase
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactI0320 111159 112505 449
(449 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YER043c [H] KOG1370 S-adenosylhomocysteine hydrolase 780 0.0
SPBC8D2.18c [H] KOG1370 S-adenosylhomocysteine hydrolase 658 0.0
7293068 [H] KOG1370 S-adenosylhomocysteine hydrolase 607 e-174
Hs9951915 [H] KOG1370 S-adenosylhomocysteine hydrolase 595 e-170
CE17154 [H] KOG1370 S-adenosylhomocysteine hydrolase 586 e-167
At4g13940 [H] KOG1370 S-adenosylhomocysteine hydrolase 472 e-133
At3g23810 [H] KOG1370 S-adenosylhomocysteine hydrolase 466 e-131
Hs17439773 [H] KOG1370 S-adenosylhomocysteine hydrolase 439 e-123
7292277 [H] KOG1370 S-adenosylhomocysteine hydrolase 408 e-114
HsM5729724 [H] KOG1370 S-adenosylhomocysteine hydrolase 407 e-113
Hs21361647 [H] KOG1370 S-adenosylhomocysteine hydrolase 407 e-113
7300202 [H] KOG1370 S-adenosylhomocysteine hydrolase 405 e-113
Hs18566749 [H] KOG1370 S-adenosylhomocysteine hydrolase 404 e-112
Hs20483309 [H] KOG1370 S-adenosylhomocysteine hydrolase 332 5e-91
Hs22051990 [H] KOG1370 S-adenosylhomocysteine hydrolase 238 1e-62
Hs22041394 [H] KOG1370 S-adenosylhomocysteine hydrolase 183 4e-46
Hs20537421 [H] KOG1370 S-adenosylhomocysteine hydrolase 165 1e-40
Hs22054319 [H] KOG1370 S-adenosylhomocysteine hydrolase 164 2e-40
Hs17439584 [H] KOG1370 S-adenosylhomocysteine hydrolase 81 3e-15
>YER043c [H] KOG1370 S-adenosylhomocysteine hydrolase
Length = 449
Score = 780 bits (2014), Expect = 0.0
Identities = 386/449 (85%), Positives = 407/449 (89%)
Query: 1 MSAPAHNYKVADISLAAFGRKEIELAEHEMPGLIAIREAYGAEQPLKGARIAGCLHMTIQ 60
MSAPA NYK+ADISLAAFGRKEIELAEHEMPGL+AIR+AYG QPLKGARIAGCLHMTIQ
Sbjct: 1 MSAPAQNYKIADISLAAFGRKEIELAEHEMPGLMAIRKAYGDVQPLKGARIAGCLHMTIQ 60
Query: 61 TAVLIETLVALGAEVTWSSCNIYSTQDHXXXXXXXSGVPVFAWKGETEEEYLWCIEQQLF 120
TAVLIETLVALGAEVTWSSCNIYSTQDH SGVPVFAWKGETEEEYLWCIEQQLF
Sbjct: 61 TAVLIETLVALGAEVTWSSCNIYSTQDHAAAAIAASGVPVFAWKGETEEEYLWCIEQQLF 120
Query: 121 AFXXXXXXXXXXXXXXXXTSLVHDKYPDMLMDCFGLSEETTTGVHHLYRMVKENKLKVPA 180
AF T+LVH+K+P+ML DCFGLSEETTTGVHHLYRMVKE KLKVPA
Sbjct: 121 AFKDNKKLNLILDDGGDLTTLVHEKHPEMLEDCFGLSEETTTGVHHLYRMVKEGKLKVPA 180
Query: 181 INVNDSVTKSKFDNLYGCRESLIDGIKRATDVMLAGKVAVVAGYGDVGKGCAAALRGFGA 240
INVNDSVTKSKFDNLYGCRESL+DGIKRATDVMLAGKVAVVAGYGDVGKGCAAALRG GA
Sbjct: 181 INVNDSVTKSKFDNLYGCRESLVDGIKRATDVMLAGKVAVVAGYGDVGKGCAAALRGMGA 240
Query: 241 RVIVTEIDPINALQAAMEGYQVIPMEEAVSSGQVFVTTTGCRDIITKEHFLQMPEDAIVC 300
RV+VTEIDPINALQAAMEGYQV+ ME+A GQVFVTTTGCRDII EHF+ MPEDAIVC
Sbjct: 241 RVLVTEIDPINALQAAMEGYQVVTMEDASHIGQVFVTTTGCRDIINGEHFINMPEDAIVC 300
Query: 301 NIGHFDIEIDVAWLKANATEVINIKPQVDRYLLPSGKHVILLADGRLVNLGCATGHSSFV 360
NIGHFDIEIDVAWLKANA E INIKPQVDRYLL SG+HVILLA+GRLVNLGCATGHSSFV
Sbjct: 301 NIGHFDIEIDVAWLKANAKECINIKPQVDRYLLSSGRHVILLANGRLVNLGCATGHSSFV 360
Query: 361 MSCSFSNQVLAQIALFKAQDKAFREKYIEFQKTGPFDIGVHVLPKILDEAVAKFHLDNLG 420
MSCSFSNQVLAQIALFK+ DK+FREK+IEFQKTGPF++GVHVLPKILDEAVAKFHL NLG
Sbjct: 361 MSCSFSNQVLAQIALFKSNDKSFREKHIEFQKTGPFEVGVHVLPKILDEAVAKFHLGNLG 420
Query: 421 VKLTKLSDVQSEYLGIPEEGPYKADHYRY 449
V+LTKLS VQSEYLGIPEEGP+KADHYRY
Sbjct: 421 VRLTKLSKVQSEYLGIPEEGPFKADHYRY 449
>SPBC8D2.18c [H] KOG1370 S-adenosylhomocysteine hydrolase
Length = 433
Score = 658 bits (1697), Expect = 0.0
Identities = 324/443 (73%), Positives = 369/443 (83%), Gaps = 14/443 (3%)
Query: 7 NYKVADISLAAFGRKEIELAEHEMPGLIAIREAYGAEQPLKGARIAGCLHMTIQTAVLIE 66
NYKVADISLAAFGRKE+E+AE+EMPGLIA+RE Y QPLKGARIAGCLHMTIQTAVLIE
Sbjct: 5 NYKVADISLAAFGRKELEIAENEMPGLIAVREKYAKSQPLKGARIAGCLHMTIQTAVLIE 64
Query: 67 TLVALGAEVTWSSCNIYSTQDHXXXXXXXSGVPVFAWKGETEEEYLWCIEQQLFAFXXXX 126
TLVALGAEVTWSSCNIYSTQDH +GVPVFAWKGETEEEYLWCIEQQL +F
Sbjct: 65 TLVALGAEVTWSSCNIYSTQDHAAAAIAATGVPVFAWKGETEEEYLWCIEQQLKSFPSGK 124
Query: 127 XXXXXXXXXXXXTSLVHDKYPDMLMDCFGLSEETTTGVHHLYRMVKENKLKVPAINVNDS 186
T+LVH+++P++L+D G+SEETTTGVH+LY+M KENKLKVPAINVNDS
Sbjct: 125 PLNMILDDGGDLTALVHERHPELLVDIRGISEETTTGVHNLYKMFKENKLKVPAINVNDS 184
Query: 187 VTKSKFDNLYGCRESLIDGIKRATDVMLAGKVAVVAGYGDVGKGCAAALRGFGARVIVTE 246
VTKSKFDNL+GC+ESL+DGIKRATDVM+AGKVAVVAG+GDVGKGC+ +LR GARVIVTE
Sbjct: 185 VTKSKFDNLFGCKESLVDGIKRATDVMIAGKVAVVAGFGDVGKGCSTSLRSQGARVIVTE 244
Query: 247 IDPINALQAAMEGYQVIPMEEAVSSGQVFVTTTGCRDIITKEHFLQMPEDAIVCNIGHFD 306
+DPINALQAAM+G++V MEEAV GQ+FVTTTGCRDII EHF +M ED+IVCNIGHFD
Sbjct: 245 VDPINALQAAMDGFEVTTMEEAVKEGQIFVTTTGCRDIIRGEHFNEMKEDSIVCNIGHFD 304
Query: 307 IEIDVAWLKANATEVINIKPQVDRYLLPSGKHVILLADGRLVNLGCATGHSSFVMSCSFS 366
+EIDVAWLKANA +V+NIKPQVDRY L +G+H+ILLADGRLVNLGCATGH SFVMSCSF+
Sbjct: 305 VEIDVAWLKANAKDVVNIKPQVDRYELKNGRHIILLADGRLVNLGCATGHPSFVMSCSFT 364
Query: 367 NQVLAQIALFKAQDKAFREKYIEFQKTGPFDIGVHVLPKILDEAVAKFHLDNLGVKLTKL 426
NQVLAQIAL+ + +GVH+LPK LDE VA+ HL LGVKLT L
Sbjct: 365 NQVLAQIALWTDNTS--------------YPLGVHMLPKKLDEEVARLHLGKLGVKLTTL 410
Query: 427 SDVQSEYLGIPEEGPYKADHYRY 449
+ VQS+YLGIP +GPYKADHYRY
Sbjct: 411 TSVQSDYLGIPVDGPYKADHYRY 433
>7293068 [H] KOG1370 S-adenosylhomocysteine hydrolase
Length = 432
Score = 607 bits (1566), Expect = e-174
Identities = 306/449 (68%), Positives = 350/449 (77%), Gaps = 17/449 (3%)
Query: 1 MSAPAHNYKVADISLAAFGRKEIELAEHEMPGLIAIREAYGAEQPLKGARIAGCLHMTIQ 60
MS P+ YKVADISLA +GRK I +AE+EMPGL+A R+ YG +PLKGARI GCLHMT+Q
Sbjct: 1 MSKPS--YKVADISLAEWGRKAIIIAENEMPGLMACRKKYGPSKPLKGARITGCLHMTVQ 58
Query: 61 TAVLIETLVALGAEVTWSSCNIYSTQDHXXXXXXXSGVPVFAWKGETEEEYLWCIEQQLF 120
TAVLIETLV LGA+V WSSCNI+STQD+ +GVPV+AWKGET+EEY+WCIEQ L
Sbjct: 59 TAVLIETLVELGAQVQWSSCNIFSTQDNAAAAIAATGVPVYAWKGETDEEYMWCIEQTL- 117
Query: 121 AFXXXXXXXXXXXXXXXXTSLVHDKYPDMLMDCFGLSEETTTGVHHLYRMVKENKLKVPA 180
F T+LVH+K+P L + GLSEETTTGVH+LY+M KE +L VPA
Sbjct: 118 VFPDGQPLNMILDDGGDLTNLVHEKFPQYLKNIKGLSEETTTGVHNLYKMFKEGRLGVPA 177
Query: 181 INVNDSVTKSKFDNLYGCRESLIDGIKRATDVMLAGKVAVVAGYGDVGKGCAAALRGFGA 240
INVNDSVTKSKFDNLYGCRESLIDGIKRATDVM+AGKV VAGYGDVGKGCA AL+GFG
Sbjct: 178 INVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVCCVAGYGDVGKGCAQALKGFGG 237
Query: 241 RVIVTEIDPINALQAAMEGYQVIPMEEAVSSGQVFVTTTGCRDIITKEHFLQMPEDAIVC 300
RVIVTE+DPINALQAAMEGY+V MEEA +FVTTTGCRDIIT H QMP+DAIVC
Sbjct: 238 RVIVTEVDPINALQAAMEGYEVTTMEEASKEASIFVTTTGCRDIITSVHLQQMPDDAIVC 297
Query: 301 NIGHFDIEIDVAWLKANATEVINIKPQVDRYLLPSGKHVILLADGRLVNLGCATGHSSFV 360
NIGHFDIEIDV WL ANA E +N+KPQVDRY + SGKH+ILLA+GRLVNLGCA GH SFV
Sbjct: 298 NIGHFDIEIDVDWLNANAKEKVNVKPQVDRYTMQSGKHIILLAEGRLVNLGCAHGHPSFV 357
Query: 361 MSCSFSNQVLAQIALFKAQDKAFREKYIEFQKTGPFDIGVHVLPKILDEAVAKFHLDNLG 420
MS SF+NQVLAQI L+ DK + +GVHVLPKILDE VA HL+ LG
Sbjct: 358 MSNSFTNQVLAQIELWTKSDK--------------YAVGVHVLPKILDEEVASLHLEKLG 403
Query: 421 VKLTKLSDVQSEYLGIPEEGPYKADHYRY 449
VKLTKL++ Q+ YLG+ + GP+K DHYRY
Sbjct: 404 VKLTKLTEKQATYLGVSQTGPFKPDHYRY 432
>Hs9951915 [H] KOG1370 S-adenosylhomocysteine hydrolase
Length = 432
Score = 595 bits (1533), Expect = e-170
Identities = 297/442 (67%), Positives = 345/442 (77%), Gaps = 16/442 (3%)
Query: 8 YKVADISLAAFGRKEIELAEHEMPGLIAIREAYGAEQPLKGARIAGCLHMTIQTAVLIET 67
YKVADI LAA+GRK +++AE+EMPGL+ +RE Y A +PLKGARIAGCLHMT++TAVLIET
Sbjct: 7 YKVADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIET 66
Query: 68 LVALGAEVTWSSCNIYSTQDHXXXXXXXSGVPVFAWKGETEEEYLWCIEQQLFAFXXXXX 127
LV LGAEV WSSCNI+STQDH +G+PV+AWKGET+EEYLWCIEQ L+
Sbjct: 67 LVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVYAWKGETDEEYLWCIEQTLY--FKDGP 124
Query: 128 XXXXXXXXXXXTSLVHDKYPDMLMDCFGLSEETTTGVHHLYRMVKENKLKVPAINVNDSV 187
T+L+H KYP +L G+SEETTTGVH+LY+M+ LKVPAINVNDSV
Sbjct: 125 LNMILDDGGDLTNLIHTKYPQLLPGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSV 184
Query: 188 TKSKFDNLYGCRESLIDGIKRATDVMLAGKVAVVAGYGDVGKGCAAALRGFGARVIVTEI 247
TKSKFDNLYGCRESLIDGIKRATDVM+AGKVAVVAGYGDVGKGCA ALRGFGARVI+TEI
Sbjct: 185 TKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEI 244
Query: 248 DPINALQAAMEGYQVIPMEEAVSSGQVFVTTTGCRDIITKEHFLQMPEDAIVCNIGHFDI 307
DPINALQAAMEGY+V M+EA G +FVTTTGC DII HF QM +DAIVCNIGHFD+
Sbjct: 245 DPINALQAAMEGYEVTTMDEACQEGNIFVTTTGCIDIILGRHFEQMKDDAIVCNIGHFDV 304
Query: 308 EIDVAWLKANATEVINIKPQVDRYLLPSGKHVILLADGRLVNLGCATGHSSFVMSCSFSN 367
EIDV WL NA E +NIKPQVDRY L +G+ +ILLA+GRLVNLGCA GH SFVMS SF+N
Sbjct: 305 EIDVKWLNENAVEKVNIKPQVDRYRLKNGRRIILLAEGRLVNLGCAMGHPSFVMSNSFTN 364
Query: 368 QVLAQIALFKAQDKAFREKYIEFQKTGPFDIGVHVLPKILDEAVAKFHLDNLGVKLTKLS 427
QV+AQI L+ DK + +GVH LPK LDEAVA+ HL L VKLTKL+
Sbjct: 365 QVMAQIELWTHPDK--------------YPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLT 410
Query: 428 DVQSEYLGIPEEGPYKADHYRY 449
+ Q++YLG+ +GP+K DHYRY
Sbjct: 411 EKQAQYLGMSCDGPFKPDHYRY 432
>CE17154 [H] KOG1370 S-adenosylhomocysteine hydrolase
Length = 437
Score = 586 bits (1510), Expect = e-167
Identities = 303/448 (67%), Positives = 341/448 (75%), Gaps = 14/448 (3%)
Query: 2 SAPAHNYKVADISLAAFGRKEIELAEHEMPGLIAIREAYGAEQPLKGARIAGCLHMTIQT 61
S PA YKVADI LA FGRKEI LAE+EMPGL+A+R YG QPLKGARIAGCLHMTIQT
Sbjct: 4 SKPA--YKVADIKLADFGRKEIILAENEMPGLMAMRSKYGPSQPLKGARIAGCLHMTIQT 61
Query: 62 AVLIETLVALGAEVTWSSCNIYSTQDHXXXXXXXSGVPVFAWKGETEEEYLWCIEQQLFA 121
AVLIETL ALGAEV WSSCNI+STQDH +GVPV+AWKGET+EEY WCIEQ +
Sbjct: 62 AVLIETLTALGAEVQWSSCNIFSTQDHAAAAIAQTGVPVYAWKGETDEEYEWCIEQTI-V 120
Query: 122 FXXXXXXXXXXXXXXXXTSLVHDKYPDMLMDCFGLSEETTTGVHHLYRMVKENKLKVPAI 181
F T+LVH KYP L GLSEETTTGVH+L +M+ + LKVPAI
Sbjct: 121 FKDGQPLNMILDDGGDLTNLVHAKYPQYLAGIRGLSEETTTGVHNLAKMLAKGDLKVPAI 180
Query: 182 NVNDSVTKSKFDNLYGCRESLIDGIKRATDVMLAGKVAVVAGYGDVGKGCAAALRGFGAR 241
NVNDSVTKSKFDNLYG RESL DGIKRATDVMLAGKVAVVAGYGDVGKG AA+L+ FG+R
Sbjct: 181 NVNDSVTKSKFDNLYGIRESLPDGIKRATDVMLAGKVAVVAGYGDVGKGSAASLKAFGSR 240
Query: 242 VIVTEIDPINALQAAMEGYQVIPMEEAVSSGQVFVTTTGCRDIITKEHFLQMPEDAIVCN 301
VIVTEIDPINALQAAMEGY+V +EEA + VTTTGC+DI+T +HF +P DAIVCN
Sbjct: 241 VIVTEIDPINALQAAMEGYEVTTLEEAAPKANIIVTTTGCKDIVTGKHFELLPNDAIVCN 300
Query: 302 IGHFDIEIDVAWLKANATEVINIKPQVDRYLLPSGKHVILLADGRLVNLGCATGHSSFVM 361
+GHFD EIDV WL NAT+ IKPQVDRY L +G+HVILLA+GRLVNLGCATGH SFVM
Sbjct: 301 VGHFDCEIDVKWLNTNATKKDTIKPQVDRYTLKNGRHVILLAEGRLVNLGCATGHPSFVM 360
Query: 362 SCSFSNQVLAQIALFKAQDKAFREKYIEFQKTGPFDIGVHVLPKILDEAVAKFHLDNLGV 421
S SF+NQVLAQ+ E + +F + +G++VLPK LDE VA HL LGV
Sbjct: 361 SNSFTNQVLAQV-----------ELWTKFGTPQEYKLGLYVLPKTLDEEVAYLHLAQLGV 409
Query: 422 KLTKLSDVQSEYLGIPEEGPYKADHYRY 449
KLTKLSD Q+ YLG+P GPYK DHYRY
Sbjct: 410 KLTKLSDEQASYLGVPVAGPYKPDHYRY 437
>At4g13940 [H] KOG1370 S-adenosylhomocysteine hydrolase
Length = 485
Score = 472 bits (1214), Expect = e-133
Identities = 264/491 (53%), Positives = 313/491 (62%), Gaps = 56/491 (11%)
Query: 2 SAPAHNYKVADISLAAFGRKEIELAEHEMPGLIAIREAYGAEQPLKGARIAGCLHMTIQT 61
++ YKV D+S A FGR E+ELAE EMPGL+A R +G QP KGARI G LHMTIQT
Sbjct: 8 TSSGREYKVKDMSQADFGRLELELAEVEMPGLMACRTEFGPSQPFKGARITGSLHMTIQT 67
Query: 62 AVLIETLVALGAEVTWSSCNIYSTQDHXXXXXXXSGVPVFAWKGETEEEYLWCIEQQLFA 121
AVLIETL ALGAEV W SCNI+STQDH VFAWKGET +EY WC E+ L
Sbjct: 68 AVLIETLTALGAEVRWCSCNIFSTQDHAAAAIARDSAAVFAWKGETLQEYWWCTERAL-D 126
Query: 122 FXXXXXXXXXXXXXXXXTSLVHD------------------------------------- 144
+ T L+H+
Sbjct: 127 WGPGGGPDLIVDDGGDATLLIHEGVKAEEIFEKTGQVPDPTSTDNPEFQIVLSIIKEGLQ 186
Query: 145 ----KYPDMLMDCFGLSEETTTGVHHLYRMVKENKLKVPAINVNDSVTKSKFDNLYGCRE 200
KY M G+SEETTTGV LY+M + L PAINVNDSVTKSKFDNLYGCR
Sbjct: 187 VDPKKYHKMKERLVGVSEETTTGVKRLYQMQQNGTLLFPAINVNDSVTKSKFDNLYGCRH 246
Query: 201 SLIDGIKRATDVMLAGKVAVVAGYGDVGKGCAAALRGFGARVIVTEIDPINALQAAMEGY 260
SL DG+ RATDVM+AGKVAV+ GYGDVGKGCAAA++ GARVIVTEIDPI ALQA MEG
Sbjct: 247 SLPDGLMRATDVMIAGKVAVICGYGDVGKGCAAAMKTAGARVIVTEIDPICALQALMEGL 306
Query: 261 QVIPMEEAVSSGQVFVTTTGCRDIITKEHFLQMPEDAIVCNIGHFDIEIDVAWLKA-NAT 319
QV+ +E+ VS +FVTTTG +DII +H +M +AIVCNIGHFD EID+ L+
Sbjct: 307 QVLTLEDVVSEADIFVTTTGNKDIIMVDHMRKMKNNAIVCNIGHFDNEIDMLGLETYPGV 366
Query: 320 EVINIKPQVDRYLLPSGK-HVILLADGRLVNLGCATGHSSFVMSCSFSNQVLAQIALFKA 378
+ I IKPQ DR++ P K +I+LA+GRL+NLGCATGH SFVMSCSF+NQV+AQ+ L+
Sbjct: 367 KRITIKPQTDRWVFPETKAGIIVLAEGRLMNLGCATGHPSFVMSCSFTNQVIAQLELW-- 424
Query: 379 QDKAFREKYIEFQKTGPFDIGVHVLPKILDEAVAKFHLDNLGVKLTKLSDVQSEYLGIPE 438
+KA +G ++ V+VLPK LDE VA HL LG +LTKLS QS+Y+ IP
Sbjct: 425 NEKA----------SGKYEKKVYVLPKHLDEKVALLHLGKLGARLTKLSKDQSDYVSIPI 474
Query: 439 EGPYKADHYRY 449
EGPYK HYRY
Sbjct: 475 EGPYKPPHYRY 485
>At3g23810 [H] KOG1370 S-adenosylhomocysteine hydrolase
Length = 485
Score = 466 bits (1200), Expect = e-131
Identities = 259/491 (52%), Positives = 310/491 (62%), Gaps = 56/491 (11%)
Query: 2 SAPAHNYKVADISLAAFGRKEIELAEHEMPGLIAIREAYGAEQPLKGARIAGCLHMTIQT 61
++ YKV D+S A FGR EIELAE EMPGL++ +G QPLKGARI G LHMTIQT
Sbjct: 8 TSSGREYKVKDMSQADFGRLEIELAEVEMPGLVSCVTEFGPSQPLKGARITGSLHMTIQT 67
Query: 62 AVLIETLVALGAEVTWSSCNIYSTQDHXXXXXXXSGVPVFAWKGETEEEYLWCIEQQLFA 121
AVLIETL ALGAEV W SCNI+STQDH VFAWKGET +EY WC E+ L
Sbjct: 68 AVLIETLTALGAEVRWCSCNIFSTQDHAAAAIARDSAAVFAWKGETLQEYWWCTERAL-D 126
Query: 122 FXXXXXXXXXXXXXXXXTSLVHD------------------------------------- 144
+ T L+H+
Sbjct: 127 WGPGGGPDLIVDDGGDATLLIHEGVKAEEIFAKNGTFPDPTSTDNPEFQIVLSIIKDGLQ 186
Query: 145 ----KYPDMLMDCFGLSEETTTGVHHLYRMVKENKLKVPAINVNDSVTKSKFDNLYGCRE 200
KY M G+SEETTTGV LY+M + L PAINVNDSVTKSKFDNLYGCR
Sbjct: 187 VDPKKYHKMKERLVGVSEETTTGVKRLYQMQETGALLFPAINVNDSVTKSKFDNLYGCRH 246
Query: 201 SLIDGIKRATDVMLAGKVAVVAGYGDVGKGCAAALRGFGARVIVTEIDPINALQAAMEGY 260
SL DG+ RATDVM+AGKVAV+ GYGDVGKGCAAA++ GARVIVTEIDPI ALQA MEG
Sbjct: 247 SLPDGLMRATDVMIAGKVAVICGYGDVGKGCAAAMKTAGARVIVTEIDPICALQALMEGL 306
Query: 261 QVIPMEEAVSSGQVFVTTTGCRDIITKEHFLQMPEDAIVCNIGHFDIEIDVAWLKA-NAT 319
QV+ +E+ VS +F TTTG +DII +H +M +AIVCNIGHFD EID+ L+
Sbjct: 307 QVLTLEDVVSEADIFCTTTGNKDIIMVDHMRKMKNNAIVCNIGHFDNEIDMLGLETYPGV 366
Query: 320 EVINIKPQVDRYLLP-SGKHVILLADGRLVNLGCATGHSSFVMSCSFSNQVLAQIALFKA 378
+ I IKPQ DR++ P + +I+LA+GRL+NLGCATGH SFVMSCSF+NQV+AQ+ L+
Sbjct: 367 KRITIKPQTDRWVFPDTNSGIIVLAEGRLMNLGCATGHPSFVMSCSFTNQVIAQLELWNE 426
Query: 379 QDKAFREKYIEFQKTGPFDIGVHVLPKILDEAVAKFHLDNLGVKLTKLSDVQSEYLGIPE 438
+ +G ++ V+VLPK LDE VA HL LG +LTKL+ QS+Y+ IP
Sbjct: 427 ------------KSSGKYEKKVYVLPKHLDEKVAALHLGKLGARLTKLTKDQSDYVSIPV 474
Query: 439 EGPYKADHYRY 449
EGPYK HYRY
Sbjct: 475 EGPYKPVHYRY 485
>Hs17439773 [H] KOG1370 S-adenosylhomocysteine hydrolase
Length = 413
Score = 439 bits (1130), Expect = e-123
Identities = 232/435 (53%), Positives = 294/435 (67%), Gaps = 30/435 (6%)
Query: 15 LAAFGRKEIELAEHEMPGLIAIREAYGAEQPLKGARIAGCLHMTIQTAVLIETLVALGAE 74
+AA+GRK +++AE++MPGL+ I E Y A +PL GARI GCLH T++TAVL+ +L+ LG E
Sbjct: 9 VAAWGRKALDIAENKMPGLMRIWERYSASKPLNGARIPGCLHRTVETAVLM-SLITLGTE 67
Query: 75 VTWSSCNIYSTQDHXXXXXXXSGVPVFAWKGETEEEYLWCIEQQLFAFXXXXXXXXXXXX 134
V WSSCNI+STQDH +G+ L C+E +
Sbjct: 68 VQWSSCNIFSTQDHAAAAIAKAGISASTGIPVLPLPRLACLEGR---------NRRGVPV 118
Query: 135 XXXXTSLVHDKYPDMLMDCFGLSEETTTGVHHLYRMVKENKLKVPAINVNDSVTKSKFDN 194
T+L+H +Y +L+ G+S+ETT GVH+LY+M+ LKVPAI+VNDS TKSKFDN
Sbjct: 119 TGDLTNLIHSEYSQLLLSFRGISKETTIGVHNLYKMMVNGILKVPAIDVNDSATKSKFDN 178
Query: 195 LYGCRESLIDGIKRATDVMLAGKVAVVAGYGDVGKGCAAALRGFGARVIVTEIDPINALQ 254
LYGC GIK+ATDVM+AGKVAVVAGYGD GK CA ALRGF A VI+T+ DPI ALQ
Sbjct: 179 LYGC------GIKQATDVMIAGKVAVVAGYGDKGKSCAQALRGFRASVIITKTDPIKALQ 232
Query: 255 AAMEGYQVIPMEEAVSSGQVFVTTTGCRDIITKEHFLQMPEDAIVCNIGHFDIEIDVAWL 314
AAMEGY+V M+EA G VFVTTTGC DII +HF Q +D IVCN G+FD+E+DV WL
Sbjct: 233 AAMEGYEVTTMDEACQEGDVFVTTTGCVDIILGQHFEQTKDDTIVCNTGYFDVEMDVKWL 292
Query: 315 KANATEVINIKPQVDRYLLPSGKHVILLADGRLVNLGCATGHSSFVMSCSFSNQVLAQIA 374
N E +N+K QVD Y L +G+ +ILLA+GRLVNL CA GH SFV S SF++QV+AQI
Sbjct: 293 NKNTVEKVNVKLQVDPYRLKNGRGIILLAEGRLVNLACAMGHPSFVRSNSFTSQVMAQIK 352
Query: 375 LFKAQDKAFREKYIEFQKTGPFDIGVHVLPKILDEAVAKFHLDNLGVKLTKLSDVQSEYL 434
L+ DK + +GVH LPK LDE+VA+ HL L +KLTKL++ Q++YL
Sbjct: 353 LWTHPDK--------------YPVGVHFLPKKLDESVAEAHLGKLNMKLTKLTEKQAQYL 398
Query: 435 GIPEEGPYKADHYRY 449
G+ P+K DHYRY
Sbjct: 399 GMSCYCPFKPDHYRY 413
>7292277 [H] KOG1370 S-adenosylhomocysteine hydrolase
Length = 521
Score = 408 bits (1049), Expect = e-114
Identities = 208/433 (48%), Positives = 285/433 (65%), Gaps = 16/433 (3%)
Query: 17 AFGRKEIELAEHEMPGLIAIREAYGAEQPLKGARIAGCLHMTIQTAVLIETLVALGAEVT 76
AFGR+EIE+AE EMPG+IA+++ ++PLK A+I GC H+ QTAVLIETLV LGA V
Sbjct: 105 AFGRREIEIAEQEMPGIIALKKRAAEDKPLKDAKIVGCTHINAQTAVLIETLVELGASVR 164
Query: 77 WSSCNIYSTQDHXXXXXXXSGVPVFAWKGETEEEYLWCIEQQLFAFXXXXXXXXXXXXXX 136
W++CNIYSTQ+ SG+P+FAW+GETEE++ WCI++ + A
Sbjct: 165 WAACNIYSTQNEVAAALAESGIPIFAWRGETEEDFWWCIDRCVNA--ENWQPNMILDDGG 222
Query: 137 XXTSLVHDKYPDMLMDCFGLSEETTTGVHHLYRMVKENKLKVPAINVNDSVTKSKFDNLY 196
T L+ KYP M G+ EE+ TGVH LY++ K KL VPA+NVNDSVTK+KFDNLY
Sbjct: 223 DATHLMLKKYPTMFKLVKGIVEESVTGVHRLYQLSKAGKLTVPAMNVNDSVTKTKFDNLY 282
Query: 197 GCRESLIDGIKRATDVMLAGKVAVVAGYGDVGKGCAAALRGFGARVIVTEIDPINALQAA 256
C+ES++D +KR+TDVM GK VV GYGDVGKGCA AL+G G V +TEIDPI ALQA+
Sbjct: 283 SCKESILDSLKRSTDVMFGGKQVVVCGYGDVGKGCAQALKGQGCIVYITEIDPICALQAS 342
Query: 257 MEGYQVIPMEEAVSSGQVFVTTTGCRDIITKEHFLQMPEDAIVCNIGHFDIEIDVAWLKA 316
M+G++V+ + E + + + VT TG ++++ +EH +M IVCN+GH + EIDV L+
Sbjct: 343 MDGFRVVKLNEVIRNVDIVVTATGNKNVVVREHMDKMKSGCIVCNMGHSNTEIDVNGLRT 402
Query: 317 NATEVINIKPQVDRYLLPSGKHVILLADGRLVNLGCATGHSSFVMSCSFSNQVLAQIALF 376
++ QVD + P GK++ILLA+GRLVNL C++ SF +S + + Q LA I LF
Sbjct: 403 PDLTWEKVRSQVDHIIWPEGKYIILLAEGRLVNLSCSS-IPSFAVSITSATQALALIELF 461
Query: 377 KAQDKAFREKYIEFQKTGPFDIGVHVLPKILDEAVAKFHLDNLGVKLTKLSDVQSEYLGI 436
A G + V++LPK +DE VA HL LT+LSD Q++Y+G+
Sbjct: 462 NA-------------PPGRYKSDVYLLPKKMDEYVASLHLPTFDAHLTELSDEQAKYMGL 508
Query: 437 PEEGPYKADHYRY 449
+ GP+K ++YRY
Sbjct: 509 NKAGPFKPNYYRY 521
>HsM5729724 [H] KOG1370 S-adenosylhomocysteine hydrolase
Length = 500
Score = 407 bits (1046), Expect = e-113
Identities = 209/448 (46%), Positives = 291/448 (64%), Gaps = 16/448 (3%)
Query: 2 SAPAHNYKVADISLAAFGRKEIELAEHEMPGLIAIREAYGAEQPLKGARIAGCLHMTIQT 61
S + N+ V +I A FGR+EIE+AE +M LI++R+ E+PL GA+I GC H+T QT
Sbjct: 69 SKGSSNFCVKNIKQAEFGRREIEIAEQDMSALISLRKRAQGEKPLAGAKIVGCTHITAQT 128
Query: 62 AVLIETLVALGAEVTWSSCNIYSTQDHXXXXXXXSGVPVFAWKGETEEEYLWCIEQQLFA 121
AVLIETL ALGA+ WS+CNIYSTQ+ +GV VFAWKGE+E+++ WCI++ +
Sbjct: 129 AVLIETLCALGAQCRWSACNIYSTQNEVAAALAEAGVAVFAWKGESEDDFWWCIDRCVNM 188
Query: 122 FXXXXXXXXXXXXXXXXTSLVHDKYPDMLMDCFGLSEETTTGVHHLYRMVKENKLKVPAI 181
T V+ KYP++ G+ EE+ TGVH LY++ K KL VPA+
Sbjct: 189 --DGWQANMILDDGGDLTHWVYKKYPNVFKKIRGIVEESVTGVHRLYQLSKAGKLCVPAM 246
Query: 182 NVNDSVTKSKFDNLYGCRESLIDGIKRATDVMLAGKVAVVAGYGDVGKGCAAALRGFGAR 241
NVNDSVTK KFDNLY CRES++DG+KR TDVM GK VV GYG+VGKGC AAL+ GA
Sbjct: 247 NVNDSVTKQKFDNLYCCRESILDGLKRTTDVMFGGKQVVVCGYGEVGKGCCAALKALGAI 306
Query: 242 VIVTEIDPINALQAAMEGYQVIPMEEAVSSGQVFVTTTGCRDIITKEHFLQMPEDAIVCN 301
V +TEIDPI ALQA M+G++V+ + E + V +T TG ++++T+EH +M IVCN
Sbjct: 307 VYITEIDPICALQACMDGFRVVKLNEVIRQVDVVITCTGNKNVVTREHLDRMKNSCIVCN 366
Query: 302 IGHFDIEIDVAWLKANATEVINIKPQVDRYLLPSGKHVILLADGRLVNLGCATGHSSFVM 361
+GH + EIDV L+ ++ QVD + P GK V+LLA+GRL+NL C+T +FV+
Sbjct: 367 MGHSNTEIDVTSLRTPELTWERVRSQVDHVIWPDGKRVVLLAEGRLLNLSCST-VPTFVL 425
Query: 362 SCSFSNQVLAQIALFKAQDKAFREKYIEFQKTGPFDIGVHVLPKILDEAVAKFHLDNLGV 421
S + + Q LA I L+ A + +++ V++LPK +DE VA HL +
Sbjct: 426 SITATTQALALIELYNAPEGRYKQ-------------DVYLLPKKMDEYVASLHLPSFDA 472
Query: 422 KLTKLSDVQSEYLGIPEEGPYKADHYRY 449
LT+L+D Q++YLG+ + GP+K ++YRY
Sbjct: 473 HLTELTDDQAKYLGLNKNGPFKPNYYRY 500
>Hs21361647 [H] KOG1370 S-adenosylhomocysteine hydrolase
Length = 530
Score = 407 bits (1046), Expect = e-113
Identities = 209/448 (46%), Positives = 291/448 (64%), Gaps = 16/448 (3%)
Query: 2 SAPAHNYKVADISLAAFGRKEIELAEHEMPGLIAIREAYGAEQPLKGARIAGCLHMTIQT 61
S + N+ V +I A FGR+EIE+AE +M LI++R+ E+PL GA+I GC H+T QT
Sbjct: 99 SKGSSNFCVKNIKQAEFGRREIEIAEQDMSALISLRKRAQGEKPLAGAKIVGCTHITAQT 158
Query: 62 AVLIETLVALGAEVTWSSCNIYSTQDHXXXXXXXSGVPVFAWKGETEEEYLWCIEQQLFA 121
AVLIETL ALGA+ WS+CNIYSTQ+ +GV VFAWKGE+E+++ WCI++ +
Sbjct: 159 AVLIETLCALGAQCRWSACNIYSTQNEVAAALAEAGVAVFAWKGESEDDFWWCIDRCVNM 218
Query: 122 FXXXXXXXXXXXXXXXXTSLVHDKYPDMLMDCFGLSEETTTGVHHLYRMVKENKLKVPAI 181
T V+ KYP++ G+ EE+ TGVH LY++ K KL VPA+
Sbjct: 219 --DGWQANMILDDGGDLTHWVYKKYPNVFKKIRGIVEESVTGVHRLYQLSKAGKLCVPAM 276
Query: 182 NVNDSVTKSKFDNLYGCRESLIDGIKRATDVMLAGKVAVVAGYGDVGKGCAAALRGFGAR 241
NVNDSVTK KFDNLY CRES++DG+KR TDVM GK VV GYG+VGKGC AAL+ GA
Sbjct: 277 NVNDSVTKQKFDNLYCCRESILDGLKRTTDVMFGGKQVVVCGYGEVGKGCCAALKALGAI 336
Query: 242 VIVTEIDPINALQAAMEGYQVIPMEEAVSSGQVFVTTTGCRDIITKEHFLQMPEDAIVCN 301
V +TEIDPI ALQA M+G++V+ + E + V +T TG ++++T+EH +M IVCN
Sbjct: 337 VYITEIDPICALQACMDGFRVVKLNEVIRQVDVVITCTGNKNVVTREHLDRMKNSCIVCN 396
Query: 302 IGHFDIEIDVAWLKANATEVINIKPQVDRYLLPSGKHVILLADGRLVNLGCATGHSSFVM 361
+GH + EIDV L+ ++ QVD + P GK V+LLA+GRL+NL C+T +FV+
Sbjct: 397 MGHSNTEIDVTSLRTPELTWERVRSQVDHVIWPDGKRVVLLAEGRLLNLSCST-VPTFVL 455
Query: 362 SCSFSNQVLAQIALFKAQDKAFREKYIEFQKTGPFDIGVHVLPKILDEAVAKFHLDNLGV 421
S + + Q LA I L+ A + +++ V++LPK +DE VA HL +
Sbjct: 456 SITATTQALALIELYNAPEGRYKQ-------------DVYLLPKKMDEYVASLHLPSFDA 502
Query: 422 KLTKLSDVQSEYLGIPEEGPYKADHYRY 449
LT+L+D Q++YLG+ + GP+K ++YRY
Sbjct: 503 HLTELTDDQAKYLGLNKNGPFKPNYYRY 530
>7300202 [H] KOG1370 S-adenosylhomocysteine hydrolase
Length = 504
Score = 405 bits (1041), Expect = e-113
Identities = 211/447 (47%), Positives = 288/447 (64%), Gaps = 17/447 (3%)
Query: 2 SAPAHNYKVADISLAAFGRKEIELAEHEMPGLIAIREAYGAEQPLKGARIAGCLHMTIQT 61
SA ++ V IS +AFGR+EIE+AE EMPG++ +R+ E+PLKGA I GC H+ Q+
Sbjct: 62 SAGGTDFCVKSISKSAFGRREIEIAESEMPGIMTLRKRAKDEKPLKGANIVGCTHVNAQS 121
Query: 62 AVLIETLVALGAEVTWSSCNIYSTQDHXXXXXXXSGVPVFAWKGETEEEYLWCIEQQLFA 121
AVLIETLV LGA V W++CNIYSTQ+ +G+P+FAW+GETEEE+ WC+++ +++
Sbjct: 122 AVLIETLVQLGATVRWAACNIYSTQNAVAAALAEAGIPIFAWRGETEEEFWWCLDRAIYS 181
Query: 122 FXXXXXXXXXXXXXXXXTSLVHDKYPDMLMDCFGLSEETTTGVHHLYRMVKENKLKVPAI 181
T L+ KYPD G+ EE+ TGVH LY + K KL VPAI
Sbjct: 182 --DGWQPNLILDDGGDATHLMLKKYPDYFKAIRGIVEESVTGVHRLYMLSKGGKLTVPAI 239
Query: 182 NVNDSVTKSKFDNLYGCRESLIDGIKRATDVMLAGKVAVVAGYGDVGKGCAAALRGFGAR 241
NVNDSVTK+KFD Y CR+S++D +KR TD+M GK V+ GYGDVGKGCA +L+G G
Sbjct: 240 NVNDSVTKNKFDTFYTCRDSILDSLKRTTDIMFGGKQVVICGYGDVGKGCAQSLKGQGCI 299
Query: 242 VIVTEIDPINALQAAMEGYQVIPMEEAVSSGQVFVTTTGCRDIITKEHFLQMPEDAIVCN 301
V VTE+DPI ALQAAM+G++V+ + E + + V VT TG +++IT++H +M I+CN
Sbjct: 300 VYVTEVDPICALQAAMDGFRVVRLNEVIRTVDVVVTATGNKNVITRDHMNRMKNGCILCN 359
Query: 302 IGHFDIEIDVAWLKANATEVINIKPQVDRYLLPSGKHVILLADGRLVNLGCATGHSSFVM 361
+GH EIDV L ++ QVD P G+ +ILLA+GRLVNL C+T SSFV+
Sbjct: 360 MGHSCSEIDVNGLHTPELTWERVRSQVDHIRWPDGRMIILLAEGRLVNLSCST-ISSFVV 418
Query: 362 SCSFSNQVLAQIALFKAQDKAFREKYIEFQKTGPFDIGVHVLPKILDEAVAKFHLDNLGV 421
S + S Q LA I LF A G + V++LPK +DE VA HL
Sbjct: 419 SVASSTQALALIELFSA--------------PGRYKSDVYLLPKKMDEYVASLHLATFDA 464
Query: 422 KLTKLSDVQSEYLGIPEEGPYKADHYR 448
LT+L+D QS+++G+ + GP+KA++YR
Sbjct: 465 HLTELTDEQSKFMGLNKAGPFKANYYR 491
>Hs18566749 [H] KOG1370 S-adenosylhomocysteine hydrolase
Length = 611
Score = 404 bits (1039), Expect = e-112
Identities = 205/448 (45%), Positives = 291/448 (64%), Gaps = 16/448 (3%)
Query: 2 SAPAHNYKVADISLAAFGRKEIELAEHEMPGLIAIREAYGAEQPLKGARIAGCLHMTIQT 61
S + ++ V +I A FGR+EIE+AE EMP L+A+R+ E+PL GA+I GC H+T QT
Sbjct: 180 SKGSSDFCVKNIKQAEFGRREIEIAEQEMPALMALRKRAQGEKPLAGAKIVGCTHITAQT 239
Query: 62 AVLIETLVALGAEVTWSSCNIYSTQDHXXXXXXXSGVPVFAWKGETEEEYLWCIEQQLFA 121
AVL+ETL ALGA+ W++CNIYST + SG PVFAWKGE+E+++ WCI++ +
Sbjct: 240 AVLMETLGALGAQCRWAACNIYSTLNEVAAALAESGFPVFAWKGESEDDFWWCIDRCVNV 299
Query: 122 FXXXXXXXXXXXXXXXXTSLVHDKYPDMLMDCFGLSEETTTGVHHLYRMVKENKLKVPAI 181
T ++ KYP+M G+ EE+ TGVH LY++ K KL VPA+
Sbjct: 300 --EGWQPNMILDDGGDLTHWIYKKYPNMFKKIKGIVEESVTGVHRLYQLSKAGKLCVPAM 357
Query: 182 NVNDSVTKSKFDNLYGCRESLIDGIKRATDVMLAGKVAVVAGYGDVGKGCAAALRGFGAR 241
NVNDSVTK KFDNLY CRES++DG+KR TD+M GK VV GYG+VGKGC AAL+ G+
Sbjct: 358 NVNDSVTKQKFDNLYCCRESILDGLKRTTDMMFGGKQVVVCGYGEVGKGCCAALKAMGSI 417
Query: 242 VIVTEIDPINALQAAMEGYQVIPMEEAVSSGQVFVTTTGCRDIITKEHFLQMPEDAIVCN 301
V VTEIDPI ALQA M+G++++ + E + + +T TG ++++T+EH +M IVCN
Sbjct: 418 VYVTEIDPICALQACMDGFRLVKLNEVIRQVDIVITCTGNKNVVTREHLDRMKNSCIVCN 477
Query: 302 IGHFDIEIDVAWLKANATEVINIKPQVDRYLLPSGKHVILLADGRLVNLGCATGHSSFVM 361
+GH + EIDVA L+ ++ QVD + P GK ++LLA+GRL+NL C+T +FV+
Sbjct: 478 MGHSNTEIDVASLRTPELTWERVRSQVDHVIWPDGKRIVLLAEGRLLNLSCST-VPTFVL 536
Query: 362 SCSFSNQVLAQIALFKAQDKAFREKYIEFQKTGPFDIGVHVLPKILDEAVAKFHLDNLGV 421
S + + Q LA I L+ A + +++ V++LPK +DE VA HL
Sbjct: 537 SITATTQALALIELYNAPEGRYKQ-------------DVYLLPKKMDEYVASLHLPTFDA 583
Query: 422 KLTKLSDVQSEYLGIPEEGPYKADHYRY 449
LT+L+D Q++YLG+ + GP+K ++YRY
Sbjct: 584 HLTELTDEQAKYLGLNKNGPFKPNYYRY 611
>Hs20483309 [H] KOG1370 S-adenosylhomocysteine hydrolase
Length = 395
Score = 332 bits (852), Expect = 5e-91
Identities = 195/442 (44%), Positives = 257/442 (58%), Gaps = 53/442 (11%)
Query: 8 YKVADISLAAFGRKEIELAEHEMPGLIAIREAYGAEQPLKGARIAGCLHMTIQTAVLIET 67
YKV DI L +G K +++ E++MPGL I + + + +A M + A+LIET
Sbjct: 7 YKVTDIGLDFWGCKALDIVENQMPGLTCI------PRRARASPVASIGPM--EMAILIET 58
Query: 68 LVALGAEVTWSSCNIYSTQDHXXXXXXXSGVPVFAWKGETEEEYLWCIEQQLFAFXXXXX 127
L+ LGA++ WSSCNI TQDH +G+PV +G + +
Sbjct: 59 LITLGAKLQWSSCNI--TQDHEAAAIAKAGIPVVRLEGRNRGGVPVVHQADIILQRRPPQ 116
Query: 128 XXXXXXXXXXXTSLVHDKYPDMLMDCFGLSEETTTGVHHLYRMVKENKLKVPAINVNDSV 187
H +P + + +ET GVH L++M+ LKVPAINVN+SV
Sbjct: 117 RDSGCRLGP------HQPHPHQVPTAL-VGDETMIGVHKLHKMMANGILKVPAINVNNSV 169
Query: 188 TKSKFDNLYGCRESLIDGIKRATDVMLAGKVAVVAGYGDVGKGCAAALRGFGARVIVTEI 247
TKSKFDNL GC+ESLID IK ATDVM+A K A VI+ +I
Sbjct: 170 TKSKFDNLSGCQESLIDSIKWATDVMIASK----------------------AHVIIIKI 207
Query: 248 DPINALQAAMEGYQVIPMEEAVSSGQVFVTTTGCRDIITKEHFLQMPEDAIVCNIGHFDI 307
DPIN LQAAM+GY+V ++EA +FVTTTGC +II HF QM +DAI+CN GHFD+
Sbjct: 208 DPINILQAAMKGYEVATIDEACQEDNIFVTTTGCVNIILGWHFKQMKDDAIICNTGHFDM 267
Query: 308 EIDVAWLKANATEVINIKPQVDRYLLPSGKHVILLADGRLVNLGCATGHSSFVMSCSFSN 367
EIDV WL N E +NIKPQVD Y L + H+ILLA+G+LVNLGCA GH SF++S SF+N
Sbjct: 268 EIDVKWLNKNTVERVNIKPQVDWYQLKNAHHIILLAEGQLVNLGCAMGHLSFLISNSFTN 327
Query: 368 QVLAQIALFKAQDKAFREKYIEFQKTGPFDIGVHVLPKILDEAVAKFHLDNLGVKLTKLS 427
QV+AQ L DK + + V LPK L+EA+A+ HL L VKLTKL+
Sbjct: 328 QVMAQTELQTHPDK--------------YQVMVLFLPKKLNEAMAEAHLGKLNVKLTKLT 373
Query: 428 DVQSEYLGIPEEGPYKADHYRY 449
++Q+ YL + +GP+K DHY Y
Sbjct: 374 ELQAHYLYLSRDGPFKPDHYHY 395
>Hs22051990 [H] KOG1370 S-adenosylhomocysteine hydrolase
Length = 648
Score = 238 bits (607), Expect = 1e-62
Identities = 139/309 (44%), Positives = 181/309 (57%), Gaps = 31/309 (10%)
Query: 9 KVADISLAAFGRKEIELAEHEMPGLIAIREAYGAEQPLKGARIAGCLHMTIQTAVLIETL 68
KV DI LAA+G K + + E+EMPGL+ + E Y A +PL+G A CLHMT+ E
Sbjct: 348 KVIDIGLAAWGCKALNIVENEMPGLMHMWELYSASKPLEGNHSASCLHMTM------EMA 401
Query: 69 VALGAEVTWSSCNIYSTQDHXXXXXXXSGVPVFAWKGETEEEYLWCIEQQLFAFXXXXXX 128
+ +G+ +T + S W + + F F
Sbjct: 402 IHIGSLITLGA-----------PAATSSSPWTMCWLP---------LPRLAFQFTPGRAK 441
Query: 129 XXXXXXXXXXTSLVHDKYPDMLMDCFGLSEETTTGVHHLYRMVKENKLKVPAINVNDSVT 188
+++ +++++ G + H MV LKVPAINVNDS+T
Sbjct: 442 ERRVPMVHRAVTVIQGWALNIILEDGG----DLANLFHTKMMVN-GILKVPAINVNDSLT 496
Query: 189 KSKFDNLYGCRESLIDGIKRATDVMLAGKVAVVAGYGDVGKGCAAALRGFGARVIVTEID 248
KS+F+ LYGC ESLIDGIK AT VM+AGKVA+VAGYG+VGKGCA AL GFGA VI+T+ID
Sbjct: 497 KSEFNKLYGCWESLIDGIKWATVVMIAGKVAMVAGYGNVGKGCAQALWGFGAHVIITKID 556
Query: 249 PINALQAAMEGYQVIPMEEAVSSGQVFVTTTGCRDIITKEHFLQMPEDAIVCNIGHFDIE 308
PINALQAAMEGY+V M+EA G +F+TTT C +II HF QM +DAIVCN GHF++E
Sbjct: 557 PINALQAAMEGYEVTTMDEACQEGNIFITTTACVNIILGRHFEQMKDDAIVCNTGHFEVE 616
Query: 309 IDVAWLKAN 317
I+V WL N
Sbjct: 617 INVKWLSEN 625
>Hs22041394 [H] KOG1370 S-adenosylhomocysteine hydrolase
Length = 283
Score = 183 bits (465), Expect = 4e-46
Identities = 115/251 (45%), Positives = 146/251 (57%), Gaps = 45/251 (17%)
Query: 49 ARIAGCLHMTIQTAVLIETLVALGAEVTWSSCNIYSTQDHXXXXXXXSGVPVFAWKGETE 108
A +A C T++TAVLIETL++LGAE S+CN++STQDH +P A++
Sbjct: 11 ASLAVCT-WTVETAVLIETLISLGAEGQLSTCNLFSTQDHAALP-----LPRLAFQCMPG 64
Query: 109 EEYLWCIEQQLFAFXXXXXXXXXXXXXXXXTSLVHDKYPDMLMDCFGLSEETTTGVHHLY 168
E + H G+S+ET TGVH+L+
Sbjct: 65 RE---------------------KQTRSTSAPVGHR----------GISQETLTGVHNLH 93
Query: 169 RMVKENKLKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMLAGKVAVVAGYGDVG 228
+M+ LKVPAINVNDSVTKSK + SL DGI +AT+V+ A KV V+ GYG+VG
Sbjct: 94 KMMANGILKVPAINVNDSVTKSK-------QASLTDGIMQATEVVTASKVVVIVGYGNVG 146
Query: 229 KGCAAALRGFGARVIVTEIDPINALQAAMEGYQVIPMEEAVSSGQVFVTTTGCRDIITKE 288
K CA ALRGF VIVTEIDPINALQAAME Y+V M++A +FVTTTGC D I
Sbjct: 147 KDCAQALRGFVDHVIVTEIDPINALQAAMESYEVTTMDKACQE-DIFVTTTGCNDSILDW 205
Query: 289 HFLQMPEDAIV 299
HF QM +DA++
Sbjct: 206 HFKQMKDDAVM 216
>Hs20537421 [H] KOG1370 S-adenosylhomocysteine hydrolase
Length = 215
Score = 165 bits (418), Expect = 1e-40
Identities = 99/242 (40%), Positives = 125/242 (50%), Gaps = 61/242 (25%)
Query: 86 QDHXXXXXXXSGVPVFAWKGETEEEYLWCIEQQLFAFXXXXXXXXXXXXXXXXTSLVHDK 145
++H +G+PVF WKG+ +E Y WCIEQ T D
Sbjct: 30 REHAVAVFAEAGMPVFTWKGKMKEGYPWCIEQ---------------------TLYFKDG 68
Query: 146 YPDMLMDCFGLSEETTTGVHHLYRMVKENKLKVPAINVNDSVTKSKFDNLYGCRESLIDG 205
+M++D G + T +H + V +
Sbjct: 69 PLNMILDDGG---DLTNLIHTKWHQVDQ-------------------------------- 93
Query: 206 IKRATDVMLAGKVAVVAGYGDVGKGCAAALRGFGARVIVTEIDPINALQAAMEGYQVIPM 265
DVM+A KVAVVAGYG VGKGCA AL+GFGA +I+TE DPI+ALQAAMEGY+V M
Sbjct: 94 -----DVMIASKVAVVAGYGGVGKGCAQALQGFGACIIITETDPISALQAAMEGYEVTTM 148
Query: 266 EEAVSSGQVFVTTTGCRDIITKEHFLQMPEDAIVCNIGHFDIEIDVAWLKANATEVINIK 325
+EA G +FVTTT C +II HF QM +DAI+CN FD+EIDV L NA E NIK
Sbjct: 149 DEACQEGNIFVTTTTCVNIILGRHFEQMKDDAILCNTEQFDVEIDVRCLNNNAVEKANIK 208
Query: 326 PQ 327
P+
Sbjct: 209 PR 210
>Hs22054319 [H] KOG1370 S-adenosylhomocysteine hydrolase
Length = 287
Score = 164 bits (415), Expect = 2e-40
Identities = 81/146 (55%), Positives = 97/146 (65%), Gaps = 2/146 (1%)
Query: 57 MTIQTAVLIETLVALGAEVTWSSCNIYSTQDHXXXXXXXSGVPVFAWKGETEEEYLWCIE 116
MT++T VL ETL+ LGAEV WSSCNI+STQDH +G+PV AWKGETEE+YLWC +
Sbjct: 1 MTVETVVLTETLLVLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVNAWKGETEEKYLWCTK 60
Query: 117 QQLFAFXXXXXXXXXXXXXXXXTSLVHDKYPDMLMDCFGLSEETTTGVHHLYRMVKENKL 176
Q L + T+L H KYP +L +SEET T VH+LY+M+ L
Sbjct: 61 QTL--YFKDKLLNMILDITGGLTNLTHTKYPQLLSGIRDISEETMTEVHNLYKMMANGIL 118
Query: 177 KVPAINVNDSVTKSKFDNLYGCRESL 202
KV INVNDSVTKSKFDNLYGC +SL
Sbjct: 119 KVSTINVNDSVTKSKFDNLYGCHQSL 144
Score = 128 bits (322), Expect = 2e-29
Identities = 72/165 (43%), Positives = 96/165 (57%), Gaps = 27/165 (16%)
Query: 285 ITKEHFLQMPEDAIVCNIGHFDIEIDVAWLKANATEVINIKPQVDRYLLPSGKHVILLAD 344
+ HF QM +DAIVCN GHFD++IDV WL NA + +G+ ILLA+
Sbjct: 150 LPNRHFEQMKDDAIVCNTGHFDVKIDVRWLNKNAMK-------------KNGRGTILLAE 196
Query: 345 GRLVNLGCATGHSSFVMSCSFSNQVLAQIALFKAQDKAFREKYIEFQKTGPFDIGVHVLP 404
+LV LGCA SFVMS SF+N V+ QI L+ DK + I VH LP
Sbjct: 197 CQLVYLGCAMDQPSFVMSNSFTNHVMVQIELWTHSDK--------------YPIEVHFLP 242
Query: 405 KILDEAVAKFHLDNLGVKLTKLSDVQSEYLGIPEEGPYKADHYRY 449
+ LDEAVA+ HL + +KLTK ++ Q++YLG+ + +K DHY Y
Sbjct: 243 RKLDEAVAEAHLGKVNMKLTKQTEKQAQYLGMSCDSLFKLDHYHY 287
>Hs17439584 [H] KOG1370 S-adenosylhomocysteine hydrolase
Length = 215
Score = 81.3 bits (199), Expect = 3e-15
Identities = 38/58 (65%), Positives = 46/58 (78%)
Query: 205 GIKRATDVMLAGKVAVVAGYGDVGKGCAAALRGFGARVIVTEIDPINALQAAMEGYQV 262
GIKR TDVM+ GKVA+VAGYGD+GKGCA AL FG ++T+I PIN LQ AM GY++
Sbjct: 103 GIKRDTDVMIVGKVAMVAGYGDMGKGCAQALWDFGDPFVITKIGPINLLQTAMGGYEI 160
Score = 61.2 bits (147), Expect = 3e-09
Identities = 28/61 (45%), Positives = 45/61 (72%)
Query: 7 NYKVADISLAAFGRKEIELAEHEMPGLIAIREAYGAEQPLKGARIAGCLHMTIQTAVLIE 66
+YKVADI LA++G K +++AE+EM GL+++ E Y +PLKG I+G ++T++ +L E
Sbjct: 41 SYKVADIDLASWGHKGLDIAENEMLGLMSVWELYLGSKPLKGTHISGWPYVTVERDILTE 100
Query: 67 T 67
T
Sbjct: 101 T 101
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.320 0.137 0.406
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,506,567
Number of Sequences: 60738
Number of extensions: 948186
Number of successful extensions: 2117
Number of sequences better than 1.0e-05: 19
Number of HSP's better than 0.0 without gapping: 19
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 2047
Number of HSP's gapped (non-prelim): 31
length of query: 449
length of database: 30,389,216
effective HSP length: 110
effective length of query: 339
effective length of database: 23,708,036
effective search space: 8037024204
effective search space used: 8037024204
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)