ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactI0545 good OPR KOG2195 General function prediction only Transferrin receptor and related proteins containing the protease-associated (PA) domain
r_klactI0545 good OPR KOG2195 Inorganic ion transport and metabolism Transferrin receptor and related proteins containing the protease-associated (PA) domain
r_klactI0545 good OPR KOG2195 Posttranslational modification, protein turnover, chaperones Transferrin receptor and related proteins containing the protease-associated (PA) domain
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactI0545 182326 183444 373
(373 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YDR415c [OPR] KOG2195 Transferrin receptor and related proteins ... 480 e-135
YBR286w [OPR] KOG2195 Transferrin receptor and related proteins ... 64 4e-10
CE08584 [OPR] KOG2195 Transferrin receptor and related proteins ... 58 3e-08
Hs4885505 [OPR] KOG2195 Transferrin receptor and related protein... 57 6e-08
Hs4758398 [OPR] KOG2195 Transferrin receptor and related protein... 54 3e-07
Hs20480969 [OPR] KOG2195 Transferrin receptor and related protei... 54 4e-07
CE12844 [OPR] KOG2195 Transferrin receptor and related proteins ... 52 1e-06
YBR074w [OR] KOG2194 Aminopeptidases of the M20 family 50 7e-06
>YDR415c [OPR] KOG2195 Transferrin receptor and related proteins containing
the protease-associated (PA) domain
Length = 374
Score = 480 bits (1236), Expect = e-135
Identities = 230/365 (63%), Positives = 287/365 (78%), Gaps = 3/365 (0%)
Query: 3 FGWFLLAASVAALPFDSLHVLEIEEGKTIMVRETEKWSLKRKGVQFMDITNFPKLLK--S 60
F F +A + P++ L VL++ E + + V E+EK +L+R+GV+F D+T L +
Sbjct: 7 FVLFNVAIIAWSYPYEPLRVLQVGENEVMEVPESEKLNLRRRGVKFFDVTKHTSFLPFFN 66
Query: 61 KDEKAVVPVYRYPKETQCDEIVNSLSKGVDKVSMHDNLAKFTSFYTRYYKSDTGYESAVW 120
K+E+ VP Y YP E E+V+ K +DK SMH NLAKFTSFYTRYYKSD G+ESA W
Sbjct: 67 KEEEPTVPTYNYPPEISNKEVVDDSIKNIDKGSMHKNLAKFTSFYTRYYKSDHGFESAEW 126
Query: 121 LSEKLSNITSPLNNDVV-IEHVQHKGWKQFSIIVSIKGAQTPENIVVMGSHQDSMNLLLP 179
L+ ++NIT + D + IEH HK WKQ+SIIV + G+ TPE+I+++GSHQDS+NLLLP
Sbjct: 127 LAATIANITKDIPQDTLTIEHFDHKEWKQYSIIVRVTGSTTPEDIIIIGSHQDSINLLLP 186
Query: 180 SILAAPGADDDGSGTVTNLEALRLYVEHLSTTGYRPNNTIEFHFYSAEEGGLLGSLDVFT 239
SI+AAPGADD+GSGTVTN+EALRLY E+ G+RPNNT+EFHFYSAEEGGLLGSLDVFT
Sbjct: 187 SIMAAPGADDNGSGTVTNMEALRLYTENFLKRGFRPNNTVEFHFYSAEEGGLLGSLDVFT 246
Query: 240 RYAEENKKVVAMLQQDMTGYVEDPENEHVGVITDYTTPGLTEFIKLIIRRFLDIPYVETE 299
YA++ K V AMLQQDMTGYV DPE+EHVG++TDYTTP LT+FIKLII +L IPY +T+
Sbjct: 247 AYAKQKKHVRAMLQQDMTGYVSDPEDEHVGIVTDYTTPALTDFIKLIINSYLSIPYRDTQ 306
Query: 300 CGYACSDHGSATKNGFPASFVIESEFNKSNKYIHSTMDTLDRLSFDHMAQHVRLVVGSLF 359
CGYACSDHGSAT+NGFP SFVIESEF K+NKYIHSTMDTLDRLS HMA+H ++V+G +
Sbjct: 307 CGYACSDHGSATRNGFPGSFVIESEFKKTNKYIHSTMDTLDRLSLAHMAEHTKIVLGVII 366
Query: 360 ELGNW 364
ELG+W
Sbjct: 367 ELGSW 371
>YBR286w [OPR] KOG2195 Transferrin receptor and related proteins containing
the protease-associated (PA) domain
Length = 563
Score = 63.9 bits (154), Expect = 4e-10
Identities = 59/213 (27%), Positives = 95/213 (43%), Gaps = 35/213 (16%)
Query: 161 PENIVVMGSHQDSMNLLLPSILAAPGADDDGSGTVTNLEALRLYVEHLSTTGYRPNNTIE 220
P+NIV +G+H DS+ PG +DDGSGT++ L + T ++ NN +
Sbjct: 331 PDNIVALGAHSDSVE-------EGPGINDDGSGTISLLNVAK------QLTHFKINNKVR 377
Query: 221 FHFYSAEEGGLLGS-LDVFTRYAEENKKVVAMLQQDMTGYVEDPENEH-VGVITDYTTPG 278
F +++AEE GLLGS + EEN K+ + DM + P E+ + + P
Sbjct: 378 FAWWAAEEEGLLGSNFYAYNLTKEENSKIRVFMDYDM---MASPNYEYEIYDANNKENPK 434
Query: 279 LTEFIKLIIRRFLDIPYVETECGYAC------SDHGSATKNGFPASFVIE-SEFNKSN-- 329
+E +K + ++D Y Y SD+ NG PA + +E N N
Sbjct: 435 GSEELKNL---YVDY-YKAHHLNYTLVPFDGRSDYVGFINNGIPAGGIATGAEKNNVNNG 490
Query: 330 ----KYIHSTMDTLDRLSFDHMAQHVRLVVGSL 358
+ H D + LS+D + +L+ S+
Sbjct: 491 KVLDRCYHQLCDDVSNLSWDAFITNTKLIAHSV 523
>CE08584 [OPR] KOG2195 Transferrin receptor and related proteins containing
the protease-associated (PA) domain
Length = 1483
Score = 57.8 bits (138), Expect = 3e-08
Identities = 39/114 (34%), Positives = 60/114 (52%), Gaps = 18/114 (15%)
Query: 150 SIIVSIKGAQTPENIVVMGSHQDSMNLLLPSILAAPGADDDGSGTVTNLEALRLYVEHLS 209
+I+ IKG+Q P+ V++ +H D+ GA D SGT T LE R ++ +
Sbjct: 380 NIMGYIKGSQEPDKFVLVSNHYDAWTY---------GAVDPNSGTSTLLEVSRALKQYQN 430
Query: 210 TTGYRPNNTIEFHFYSAEEGGLLGSLDVFTRYAEE-----NKKVVAMLQQDMTG 258
TG+ P +I F + AEE GL+GS T +AEE ++ VA++ D+ G
Sbjct: 431 QTGWIPARSILFAHWDAEEYGLIGS----TEFAEEYRLQLMRRAVAVINMDLIG 480
>Hs4885505 [OPR] KOG2195 Transferrin receptor and related proteins containing
the protease-associated (PA) domain
Length = 740
Score = 56.6 bits (135), Expect = 6e-08
Identities = 39/112 (34%), Positives = 59/112 (51%), Gaps = 17/112 (15%)
Query: 149 FSIIVSIKGAQTPENIVVMGSHQDSMNLLLPSILAAPGADDDGSGTVTNLEALRLYVEHL 208
++++ +I+G+ P+ V++G H+DS GA D SG E R + + L
Sbjct: 346 YNVVGTIRGSVEPDRYVILGGHRDSWVF---------GAIDPTSGVAVLQEIARSFGK-L 395
Query: 209 STTGYRPNNTIEFHFYSAEEGGLLGSLDVFTRYAEENKKVVAMLQQDMTGYV 260
+ G+RP TI F + AEE GLLGS T +AEEN K+ LQ+ Y+
Sbjct: 396 MSKGWRPRRTIIFASWDAEEFGLLGS----TEWAEENVKI---LQERSIAYI 440
>Hs4758398 [OPR] KOG2195 Transferrin receptor and related proteins containing
the protease-associated (PA) domain
Length = 750
Score = 54.3 bits (129), Expect = 3e-07
Identities = 39/121 (32%), Positives = 61/121 (50%), Gaps = 17/121 (14%)
Query: 140 HVQHKGWKQFSIIVSIKGAQTPENIVVMGSHQDSMNLLLPSILAAPGADDDGSGTVTNLE 199
H ++ + +++I +++GA P+ V++G H+DS G D SG E
Sbjct: 347 HSTNEVTRIYNVIGTLRGAVEPDRYVILGGHRDSWVF---------GGIDPQSGAAVVHE 397
Query: 200 ALRLYVEHLSTTGYRPNNTIEFHFYSAEEGGLLGSLDVFTRYAEENKKVVAMLQQDMTGY 259
+R + L G+RP TI F + AEE GLLGS T +AEEN + +LQ+ Y
Sbjct: 398 IVRSFGT-LKKEGWRPRRTILFASWDAEEFGLLGS----TEWAEENSR---LLQERGVAY 449
Query: 260 V 260
+
Sbjct: 450 I 450
>Hs20480969 [OPR] KOG2195 Transferrin receptor and related proteins containing
the protease-associated (PA) domain
Length = 693
Score = 53.9 bits (128), Expect = 4e-07
Identities = 58/230 (25%), Positives = 93/230 (40%), Gaps = 38/230 (16%)
Query: 140 HVQHKGWKQFSIIVSIKGAQTPENIVVMGSHQDSMNLLLPSILAAPGADDDGSGTVTNLE 199
H ++ + +++I +++GA P+ V++G H+DS G D SG E
Sbjct: 290 HSTNEVTRIYNVIGTLRGAVEPDRYVILGGHRDSWVF---------GGIDPQSGAAVVHE 340
Query: 200 ALRLYVEHLSTTGYRPNNTIEFHFYSAEEGGLLGSLDVFTRYAEENKKVVAMLQQDMTGY 259
+R + L G+RP TI F + AEE GLLGS T +AE+N + +LQ+ Y
Sbjct: 341 TVRSFGT-LKKEGWRPRRTILFASWDAEEFGLLGS----TEWAEDNSR---LLQERGVAY 392
Query: 260 VEDPENEHVGVITDYTTPGLTEFIKLIIRRFLDIPYVETECGYACSDHGSATKNGFPASF 319
+ N + +YT +D + Y + + GF
Sbjct: 393 I----NADSSIEGNYTLR-------------VDCTPLMYSLVYNLTKELKSPDEGFEGKS 435
Query: 320 VIESEFNKSNKYIHSTMDTLDRL----SFDHMAQHVRLVVGSLFELGNWE 365
+ ES KS S M + +L F+ Q + + G NWE
Sbjct: 436 LYESWTKKSPSPEFSGMPRISKLGSGNDFEVFFQRLGIASGRARYTKNWE 485
>CE12844 [OPR] KOG2195 Transferrin receptor and related proteins containing
the protease-associated (PA) domain
Length = 751
Score = 52.0 bits (123), Expect = 1e-06
Identities = 32/111 (28%), Positives = 57/111 (50%), Gaps = 18/111 (16%)
Query: 150 SIIVSIKGAQTPENIVVMGSHQDSMNLLLPSILAAPGADDDGSGTVTNLEALRLYVEHLS 209
++I I+G++ P++ +++G+H D+ G+ D SGT E R ++ ++
Sbjct: 348 NVIGYIRGSEEPDSYIMLGNHFDAW---------VYGSIDPNSGTAVLAEVARAMMQTIN 398
Query: 210 TTGYRPNNTIEFHFYSAEEGGLLGSLDVFTRYAEE-----NKKVVAMLQQD 255
T ++P TI F+ + AEE GL+GS T + EE K+ V + D
Sbjct: 399 ETSWKPARTIVFNAWDAEEFGLIGS----TEFVEEFVNILQKRAVVYINMD 445
>YBR074w [OR] KOG2194 Aminopeptidases of the M20 family
Length = 413
Score = 49.7 bits (117), Expect = 7e-06
Identities = 33/104 (31%), Positives = 52/104 (49%), Gaps = 13/104 (12%)
Query: 150 SIIVSIKGAQTPENIVVMGSHQDSMNLLLPSILAAPGADDDGSGTVTNLEALRLYVEHLS 209
+I+V ++G E +++ +H DS + GA DDG G V+ L L+ +++H
Sbjct: 136 NILVKLEGKNPEEEGLLLSAHFDS-------VPTGYGATDDGMGVVSLLANLKYHIKH-- 186
Query: 210 TTGYRPNNTIEFHFYSAEEGGLLGSLDVFTRYAEENKKVVAMLQ 253
RPN T+ F+F + EE GLLG+ F K V L+
Sbjct: 187 ----RPNRTLIFNFNNNEEFGLLGASTYFDHSWSNLTKYVINLE 226
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.317 0.134 0.391
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,954,179
Number of Sequences: 60738
Number of extensions: 983405
Number of successful extensions: 2493
Number of sequences better than 1.0e-05: 8
Number of HSP's better than 0.0 without gapping: 1
Number of HSP's successfully gapped in prelim test: 7
Number of HSP's that attempted gapping in prelim test: 2477
Number of HSP's gapped (non-prelim): 11
length of query: 373
length of database: 30,389,216
effective HSP length: 108
effective length of query: 265
effective length of database: 23,829,512
effective search space: 6314820680
effective search space used: 6314820680
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)