ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactI0580 good O KOG2628 Posttranslational modification, protein turnover, chaperones Farnesyl cysteine-carboxyl methyltransferase
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactI0580 193623 194366 248
(248 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YDR410c [O] KOG2628 Farnesyl cysteine-carboxyl methyltransferase 261 8e-70
SPAC10F6.12c [O] KOG2628 Farnesyl cysteine-carboxyl methyltransf... 183 2e-46
7294512 [O] KOG2628 Farnesyl cysteine-carboxyl methyltransferase 175 6e-44
Hs6912430 [O] KOG2628 Farnesyl cysteine-carboxyl methyltransferase 172 4e-43
CE09533 [O] KOG2628 Farnesyl cysteine-carboxyl methyltransferase 155 7e-38
CE12288 [O] KOG2628 Farnesyl cysteine-carboxyl methyltransferase 154 9e-38
At5g23320 [O] KOG2628 Farnesyl cysteine-carboxyl methyltransferase 144 9e-35
At5g08340 [O] KOG2628 Farnesyl cysteine-carboxyl methyltransferase 106 3e-23
>YDR410c [O] KOG2628 Farnesyl cysteine-carboxyl methyltransferase
Length = 239
Score = 261 bits (666), Expect = 8e-70
Identities = 120/232 (51%), Positives = 166/232 (70%)
Query: 16 DGKTFPNIQKNELDEISLTAFMLGVIFGVSLITLCLSPFWNFNIYMISLSIFHLLEFWIT 75
D +P+I++N L E+++T+++LG++ G+ + F NFN+++I+LS+FH LE++IT
Sbjct: 8 DEHEYPDIRRNPLHEVTMTSYILGILLGIFVGLFPQIRFKNFNLFIIALSLFHFLEYYIT 67
Query: 76 AKYNPGKLNTNSFLINNGVGYFLAHSVALIETIIERLLFPSFKSTTYSFYNEFIXXXXXX 135
AKYNP K+++ SFL+NNG Y AHS A++E ++E LFP K +YS +
Sbjct: 68 AKYNPLKVHSESFLLNNGKSYMAAHSFAILECLVESFLFPDLKIFSYSLATKLCTVLGCL 127
Query: 136 XXXXXQYVRSSAMITAGQSFSHVVKVTKNSDHTLVTSGIYSKSRHPSYFGFFWWSVGSQL 195
QY R+ AM TAG SFSH+VK K SDH LV +G+YS SRHPSY GFFWW++G+QL
Sbjct: 128 LVILGQYTRTIAMHTAGHSFSHIVKTKKESDHVLVKTGVYSWSRHPSYLGFFWWAIGTQL 187
Query: 196 MLLNPVSLVIFIVVLWKFFNSRIAFEERYLVQFFGNQYITYRETVGVGIPFI 247
+LLNP+SLVIFI VLWKFF+ RI EE+YL++FF +YI Y+ VGVGIPFI
Sbjct: 188 LLLNPLSLVIFIFVLWKFFSDRIRVEEKYLIEFFSAEYIEYKNKVGVGIPFI 239
>SPAC10F6.12c [O] KOG2628 Farnesyl cysteine-carboxyl methyltransferase
Length = 236
Score = 183 bits (464), Expect = 2e-46
Identities = 101/227 (44%), Positives = 137/227 (59%), Gaps = 14/227 (6%)
Query: 31 ISLTAFMLGVIFGVSLITLCLSPFWNFNIYMISLSIFHLLEFWITAKYNPGKLNTNSFLI 90
I LT+ LG +FG+ + + + + LS+FHLLEF+ITA++ +L+ +SF++
Sbjct: 13 ICLTSAFLGCVFGLGFFVWIIYGY-SIGGFFAFLSLFHLLEFYITARFQGSQLSWDSFIL 71
Query: 91 NNGVGYFLAHSVALIET----------IIERLLFPSFKSTTYSFYNEFIXXXXXXXXXXX 140
NNG Y+LA V L+E +I L FPSF +F
Sbjct: 72 NNGKAYWLAMLVGLLECLLSGGKSFAKVINCLRFPSF---LINFIFSVYQTSALGFLCLG 128
Query: 141 QYVRSSAMITAGQSFSHVVKVTKNSDHTLVTSGIYSKSRHPSYFGFFWWSVGSQLMLLNP 200
QY+RSSAM+ AGQSFSH+V +N DH LVT GIY+ RHPSY GFF W++G+Q++L N
Sbjct: 129 QYLRSSAMVQAGQSFSHIVASKRNKDHLLVTDGIYAYVRHPSYVGFFIWALGTQMLLGNF 188
Query: 201 VSLVIFIVVLWKFFNSRIAFEERYLVQFFGNQYITYRETVGVGIPFI 247
VS ++F +VLWKFF+ RI EE YLV FFG+ Y YR+ V GIP I
Sbjct: 189 VSTLLFSLVLWKFFSQRITTEEAYLVSFFGDSYEQYRKKVPSGIPLI 235
>7294512 [O] KOG2628 Farnesyl cysteine-carboxyl methyltransferase
Length = 299
Score = 175 bits (443), Expect = 6e-44
Identities = 89/228 (39%), Positives = 139/228 (60%), Gaps = 8/228 (3%)
Query: 23 IQKNELDEISLTAFMLGVIFGVSLITLCLSP--FWNFNIYMISLSIFHLLEFWITAKYNP 80
+ +N ++++ A LG VS++ +C +P + F Y +S+FH EF + A NP
Sbjct: 73 VLRNHDYQVAIRASFLGFAMAVSVLVICFAPTEWQQFGAYGCFMSLFHYSEFLVIAFANP 132
Query: 81 GKLNTNSFLINNGVGYFLAHSVALIETIIERLLFPSFKSTTYSFYNEFIXXXXXXXXXXX 140
L+ +SF++N+ V Y LA + + IE +E P FK Y I
Sbjct: 133 RTLSLDSFMLNHSVHYGLAAAASWIEFSLEVYYLPQFKRYGY------IWVAGVVLCLLG 186
Query: 141 QYVRSSAMITAGQSFSHVVKVTKNSDHTLVTSGIYSKSRHPSYFGFFWWSVGSQLMLLNP 200
+ VR +A+ITAG+SF+H+V+ K+S+H L+TSGIY+ RHPSY G+FWWS+G+Q++LLNP
Sbjct: 187 EMVRKAAIITAGRSFTHLVQNEKHSEHKLITSGIYAYCRHPSYVGWFWWSIGTQIVLLNP 246
Query: 201 VSLVIFIVVLWKFFNSRIAFEERYLVQFFGNQYITYRETVGVGIPFIK 248
+ + I+ +V W FF+ RI EE L+ FF + Y+ Y++ V G+PFI+
Sbjct: 247 ICICIYTLVSWLFFHDRIYVEEYSLLNFFQSDYVRYQKRVPTGLPFIR 294
>Hs6912430 [O] KOG2628 Farnesyl cysteine-carboxyl methyltransferase
Length = 284
Score = 172 bits (436), Expect = 4e-43
Identities = 86/220 (39%), Positives = 136/220 (61%), Gaps = 7/220 (3%)
Query: 30 EISLTAFMLGVIFGV-SLITLCLSPFWNFNIYMISLSIFHLLEFWITAKYNPGKLNTNSF 88
+I++ A LG +FG +L++ S + +F YM SLS+FH E+ +TA NP L+ +SF
Sbjct: 65 QIAIRACFLGFVFGCGTLLSFSQSSWSHFGWYMCSLSLFHYSEYLVTAVNNPKSLSLDSF 124
Query: 89 LINNGVGYFLAHSVALIETIIERLLFPSFKSTTYSFYNEFIXXXXXXXXXXXQYVRSSAM 148
L+N+ + Y +A + +E +E + +P K T+ + + +R +AM
Sbjct: 125 LLNHSLEYTVAALSSWLEFTLENIFWPELKQITW------LSVTGLLMVVFGECLRKAAM 178
Query: 149 ITAGQSFSHVVKVTKNSDHTLVTSGIYSKSRHPSYFGFFWWSVGSQLMLLNPVSLVIFIV 208
TAG +F+HVV+ K+ HTLVTSG+Y+ RHPSY G+F+WS+G+Q+ML NP+ V + +
Sbjct: 179 FTAGSNFNHVVQNEKSDTHTLVTSGVYAWFRHPSYVGWFYWSIGTQVMLCNPICGVSYAL 238
Query: 209 VLWKFFNSRIAFEERYLVQFFGNQYITYRETVGVGIPFIK 248
+W+FF R EE L+ FFG +Y+ Y++ V G+PFIK
Sbjct: 239 TVWRFFRDRTEEEEISLIHFFGEEYLEYKKRVPTGLPFIK 278
>CE09533 [O] KOG2628 Farnesyl cysteine-carboxyl methyltransferase
Length = 295
Score = 155 bits (391), Expect = 7e-38
Identities = 83/223 (37%), Positives = 124/223 (55%), Gaps = 10/223 (4%)
Query: 29 DEISLTAFMLGVIFGVSLITLCL--SPFWN-FNIYMISLSIFHLLEFWITAKYNPGKLNT 85
++I + A LG V+L+ W F+ Y + LS+FH EF TA N L
Sbjct: 75 NQILMPAAFLGCAVAVNLVYTVAHEGELWEYFSRYFLFLSVFHFSEFVFTALTNRRTLGP 134
Query: 86 NSFLINNGVGYFLAHSVALIETIIERLLFPSFKSTTYSFYNEFIXXXXXXXXXXXQYVRS 145
+SFL+ + GY+LA S+ IE +IE +P K + + F + VR
Sbjct: 135 DSFLLKHSFGYWLAASIGWIEFLIEANFYPEIKMYSVLWIGTF-------GCIIGEIVRK 187
Query: 146 SAMITAGQSFSHVVKVTKNSDHTLVTSGIYSKSRHPSYFGFFWWSVGSQLMLLNPVSLVI 205
M+ AG +F+H++ TK S HTL+ +GIY+ RHP YFG+F W+V +Q++L NP+S VI
Sbjct: 188 VGMVHAGLAFTHLMARTKRSGHTLINTGIYAYMRHPGYFGWFIWAVSTQIVLCNPISFVI 247
Query: 206 FIVVLWKFFNSRIAFEERYLVQFFGNQYITYRETVGVGIPFIK 248
+ V W+FF +RI EE+ L+ FFG+ Y Y+ G+PF +
Sbjct: 248 YTFVTWRFFANRIEIEEKDLISFFGDDYAEYQRKTWSGVPFAR 290
>CE12288 [O] KOG2628 Farnesyl cysteine-carboxyl methyltransferase
Length = 293
Score = 154 bits (390), Expect = 9e-38
Identities = 78/189 (41%), Positives = 111/189 (58%), Gaps = 7/189 (3%)
Query: 60 YMISLSIFHLLEFWITAKYNPGKLNTNSFLINNGVGYFLAHSVALIETIIERLLFPSFKS 119
Y + LS+FH EF TA N L +SFL+N+ VGY+LA S++ IE +IE FP K
Sbjct: 107 YFLFLSMFHFTEFVFTALTNRRTLRPDSFLLNHSVGYWLAASISWIEFLIEAYFFPEIKM 166
Query: 120 TTYSFYNEFIXXXXXXXXXXXQYVRSSAMITAGQSFSHVVKVTKNSDHTLVTSGIYSKSR 179
I + R M+ AG +F+H + +TK SDH LV GIY+ R
Sbjct: 167 RG-------ILWIGTLGCIIGEIFRKVGMVHAGLAFTHRLAMTKRSDHRLVKDGIYAYLR 219
Query: 180 HPSYFGFFWWSVGSQLMLLNPVSLVIFIVVLWKFFNSRIAFEERYLVQFFGNQYITYRET 239
HP YFG+F W+V +Q++L NP+ V++ V W FF SRI EE+ L+ FFG+ Y+ Y++
Sbjct: 220 HPGYFGWFLWAVSTQIILCNPICCVVYAYVTWHFFASRIYDEEKDLISFFGDSYVEYQQN 279
Query: 240 VGVGIPFIK 248
V G+PF++
Sbjct: 280 VWCGVPFVR 288
>At5g23320 [O] KOG2628 Farnesyl cysteine-carboxyl methyltransferase
Length = 197
Score = 144 bits (364), Expect = 9e-35
Identities = 76/188 (40%), Positives = 112/188 (59%), Gaps = 9/188 (4%)
Query: 61 MISLSIFHLLEFWITAK-YNPGKLNTNSFLINNGVGYFLAHSVALIETIIERLLFPSFKS 119
++SL FH+ E+ + + + +S LI Y LA ++L+E + E +LFP K
Sbjct: 17 LLSLIFFHISEYILAITIHGASNVTLSSLLITKH--YALAMLLSLLEYLTEIILFPGLKQ 74
Query: 120 TTYSFYNEFIXXXXXXXXXXXQYVRSSAMITAGQSFSHVVKVTKNSDHTLVTSGIYSKSR 179
+ ++ + +R +A+ITAG+SF+H++K+ H LVT G+Y R
Sbjct: 75 ------HWWVSNFGLIMIIVGEIIRKAAIITAGRSFTHLIKINYEEHHGLVTHGVYRLMR 128
Query: 180 HPSYFGFFWWSVGSQLMLLNPVSLVIFIVVLWKFFNSRIAFEERYLVQFFGNQYITYRET 239
HPSY GF WSVG+Q+ML NPVS V F VV+W+FF RI +EE +L QFFG QY+ Y E+
Sbjct: 129 HPSYCGFLIWSVGTQVMLCNPVSAVAFAVVVWRFFAQRIPYEEYFLNQFFGVQYLEYAES 188
Query: 240 VGVGIPFI 247
V G+PF+
Sbjct: 189 VASGVPFV 196
>At5g08340 [O] KOG2628 Farnesyl cysteine-carboxyl methyltransferase
Length = 508
Score = 106 bits (264), Expect = 3e-23
Identities = 64/186 (34%), Positives = 95/186 (50%), Gaps = 29/186 (15%)
Query: 62 ISLSIFHLLEFWIT-AKYNPGKLNTNSFLINNGVGYFLAHSVALIETIIERLLFPSFKST 120
+++ FH E+ + A + K+ +S LI+ Y LA ++++E I E + FP K
Sbjct: 18 LAIIFFHTSEYILAIAIHGASKVTLSSLLISKH--YALAMLISVLEYIAEIVFFPGLKQ- 74
Query: 121 TYSFYNEFIXXXXXXXXXXXQYVRSSAMITAGQSFSHVVKVTKNSDHTLVTSGIYSKSRH 180
+ +I + +R +A+ITA G+Y RH
Sbjct: 75 -----HWWISNFGLTMIILGEILRKTAIITA--------------------EGVYQIMRH 109
Query: 181 PSYFGFFWWSVGSQLMLLNPVSLVIFIVVLWKFFNSRIAFEERYLVQFFGNQYITYRETV 240
PSY GF WSVG+Q+ML NP+S + F VV+W+FF RI +EE YL QFFG QY+ Y + V
Sbjct: 110 PSYSGFLIWSVGTQVMLCNPISAIAFAVVVWRFFAERIPYEEHYLKQFFGRQYVEYAQRV 169
Query: 241 GVGIPF 246
G+ F
Sbjct: 170 PSGLGF 175
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.326 0.141 0.426
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,567,397
Number of Sequences: 60738
Number of extensions: 522703
Number of successful extensions: 1499
Number of sequences better than 1.0e-05: 8
Number of HSP's better than 0.0 without gapping: 8
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 1484
Number of HSP's gapped (non-prelim): 8
length of query: 248
length of database: 30,389,216
effective HSP length: 104
effective length of query: 144
effective length of database: 24,072,464
effective search space: 3466434816
effective search space used: 3466434816
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)