ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactI0623 good U KOG2081 Intracellular trafficking, secretion, and vesicular transport Nuclear transport regulator
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactI0623 205567 208449 961
(961 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YOR160w [U] KOG2081 Nuclear transport regulator 929 0.0
SPBC11G11.07 [U] KOG2081 Nuclear transport regulator 194 6e-49
7295915 [U] KOG2081 Nuclear transport regulator 165 3e-40
Hs6912734 [U] KOG2081 Nuclear transport regulator 137 8e-32
Hs7662266 [YU] KOG2022 Nuclear transport receptor LGL2 (importin... 108 5e-23
At5g62600 [U] KOG2081 Nuclear transport regulator 86 3e-16
7300343 [YU] KOG2022 Nuclear transport receptor LGL2 (importin b... 72 5e-12
CE11000 [U] KOG2081 Nuclear transport regulator 67 1e-10
>YOR160w [U] KOG2081 Nuclear transport regulator
Length = 972
Score = 929 bits (2401), Expect = 0.0
Identities = 469/976 (48%), Positives = 665/976 (68%), Gaps = 31/976 (3%)
Query: 4 QIPDIKSALICTQSVSEQEKKIQALQFLEQFQKSIEAWQICFEVLSKHEADN--LQLQMF 61
Q+ DI++AL C S + Q+ K +ALQFLEQFQ+S AW IC E+LSK + N L+L +F
Sbjct: 5 QVSDIETALQCISSTASQDDKNKALQFLEQFQRSTVAWSICNEILSKEDPTNALLELNIF 64
Query: 62 ACQTLVNKVTYDLNQVNTELESFKGKLFEFIAMYEEKIIVTQLNVALARFTIQYLDWRNP 121
A QTL NKVTYDL+Q+ L FK L + + +K+I+TQLNVALAR IQ+L+W+NP
Sbjct: 65 AAQTLRNKVTYDLSQLENNLPQFKDSLLTLLLSHNQKLIITQLNVALARLAIQFLEWQNP 124
Query: 122 LVEIIXXXXXXXXXXXXXXXXXXXXXXDIKSTPLSQDEFECRTHELIDNIGEDVLKFLIS 181
+ EII DI ST L++ EF R HELID I EDVLKFL+S
Sbjct: 125 IFEIISLLNSSPSILLNFLRILPEETLDIASTSLTEVEFNSRIHELIDPIAEDVLKFLVS 184
Query: 182 CLDRV-GTEG-----ISASKIISCFGSWCYEFPIEQVLQVTPLINTVFQVLHTSYDTDSD 235
C+D + T+G IS +I+ C SW YEFP+EQ+L V PLIN VF+ + ++D +
Sbjct: 185 CIDLLQNTDGNSSSSISLEQILRCLNSWSYEFPVEQLLTVQPLINLVFETISNGNESDME 244
Query: 236 SFEAAVECLCVLLRETRDAANDTIIHALYEQLLALQQKLLPITTISDW---EEYEE-IMD 291
+F++A++CLCV+LRE+RD N+ +I AL+ QL+ LQ+KLLP T +D +EY++ +++
Sbjct: 245 AFDSAIDCLCVILRESRDTTNEQLISALFHQLMLLQEKLLP-TLFTDHPLNDEYDDDLLE 303
Query: 292 PLTRLFVEAGEAWCVFLAKNPALFKPLVEVILVLTCKNTDLDIVSYTFPFWFNLRQMLVL 351
+TRLFVEAGEAW V ++KNP FKP+V V+L+LTCKN DLD+VSYTFPFWFN +Q LVL
Sbjct: 304 GMTRLFVEAGEAWSVVISKNPDFFKPMVLVLLMLTCKNEDLDVVSYTFPFWFNFKQSLVL 363
Query: 352 QRYAQQRKEYQDVFINLTNGLITHLHYPETVFENKEDEDKFKDFRYNIGDVLKSCAAVLG 411
RY + RK Y D+F+ L NG+ITHL YP F +KE+EDKFKDFRY++GDVLK C AV+G
Sbjct: 364 PRYQESRKAYSDIFVKLINGIITHLQYPSGQFSSKEEEDKFKDFRYHMGDVLKDCTAVVG 423
Query: 412 STVALQQPYNLINQYLQKEDPNTVWQPLEAALFAVRTMAHEISHTENVVLPQLFKQLCIH 471
++ AL QP I ++ N WQ +EA LF++RTMA EIS TEN +LP++ K +C
Sbjct: 424 TSEALSQPLIRIKSAIEN---NNSWQIMEAPLFSLRTMAKEISLTENTILPEIIKIICNL 480
Query: 472 PLTHPKLVYSTILVFSRYTEWTSKHEDLLEIQLNYIFNGFEAGQSNHDLS---VAASNAL 528
P K+ Y++ LV RYTEWT+KH +LLE+QL YIFNGF+ + + D+ A+S+AL
Sbjct: 481 P-EQAKIRYASTLVLGRYTEWTAKHPELLEVQLQYIFNGFQLHEGSSDMQSIITASSHAL 539
Query: 529 MYFCQDCSSLLVNYCGQLVDFIWKIERAVDNYSMFEMCQGLSSVINEQETAKIGGIFNSF 588
M+FC DCS LLV Y QL++F ++ ++D S FE+CQGLS+VIN Q AK+ IF
Sbjct: 540 MFFCSDCSKLLVGYIDQLINFFLNVQSSIDIESQFELCQGLSAVINNQPEAKVSVIFQKL 599
Query: 589 TSQHNKRFDIIIQQFISNPSDPDLSAKVAHYIDLLYAILENIVPKFEYPEQGVEEPLIAS 648
+ ++ + +I Q+ +NP+ L+ ++A IDLLYA+ E + P++ YP+QG EPL+
Sbjct: 600 VDDNLRQIEALIPQWKANPT--LLAPQIADKIDLLYALFEELKPRYNYPQQG-SEPLLPR 656
Query: 649 ISEHITKLIN--LLDAYAISNVIIVDRTMKFFRRVFEKYHLFTQPILPAVSEFVAKGYST 706
I E I K + L+DA A+++ IIV+R K RR+FE++H+F +PILP+V+EF+ +GY T
Sbjct: 657 I-EFIWKALRTLLVDAGAMTDSIIVERVAKLLRRIFERFHVFCEPILPSVAEFLIQGYLT 715
Query: 707 SGLGAYLWFSGSIIYVYGDDEYYPVDVQVKEAVWQFACQQCSTF---FNNFKSMQTLDKF 763
+G G+YLW SGS+I ++GDDE +P+ +K+AVW+FA QC TF FN F +Q L+ +
Sbjct: 716 TGFGSYLWCSGSLIVIFGDDESFPISPSLKDAVWKFALSQCETFILNFNKFDKLQ-LNDY 774
Query: 764 FEMVHDFFLMCNDLLMFFPEHMMNTPVLISSLIQWDLESLPKLDNFEAYMTLIRFLDDLS 823
E + DFF + +DL+MF+P +N+ L+ ++ LE + KLDN++AY+ ++R LDD+
Sbjct: 775 HEAIIDFFSLISDLIMFYPGAFLNSTELLGPVLNVALECVNKLDNYDAYICILRCLDDII 834
Query: 824 SWGFKTPPISVTSITEVPDAWRCTILEQVVSKNGSNIVTALINGLVTNFDSRAHQEIISL 883
SWGFKTPPIS SI VPD WR ++ +VV +G+ ++ L GLVT F++ AH + IS
Sbjct: 835 SWGFKTPPISTVSIEIVPDEWRKQVINEVVIAHGNQLILVLFIGLVTTFENTAHSDAISC 894
Query: 884 IVKIFRLATENNNNDPSVCLEWLDSALRKMGTIESNERSKL-MSIGNALIQRDYRRCRGN 942
IVK R+ TE NNND ++C++W+ + ++G + NER L ++ L +DYR+ R
Sbjct: 895 IVKCLRILTEANNNDATICIDWIYKVVEQLGQVTLNERDNLAKAVVEGLNSKDYRKVREG 954
Query: 943 IKDFIDWYLRKHISSR 958
I+ F+ WY RK+I+SR
Sbjct: 955 IRAFVGWYSRKNINSR 970
>SPBC11G11.07 [U] KOG2081 Nuclear transport regulator
Length = 378
Score = 194 bits (493), Expect = 6e-49
Identities = 127/383 (33%), Positives = 201/383 (52%), Gaps = 24/383 (6%)
Query: 10 SALICTQSVSEQEKKIQALQFLEQFQKSIEAWQICFEVLSKHEADNLQLQMFACQTLVNK 69
SAL + +++E+K+QA +LE+FQKS AWQICF +L++ ++ +++ ++FA QTL K
Sbjct: 6 SALATLYANTDREQKLQANNYLEEFQKSPAAWQICFSILNQDDS-SIEAKLFAAQTLRQK 64
Query: 70 VTYDLNQVNTELE-SFKGKLFE-FIAMYEE-KIIVTQLNVALARFTIQYLDWRNPLVEII 126
+ YD +Q+ E F+ L + F+A + + ++ L V +A + +W N + ++
Sbjct: 65 IVYDFHQLPKETHIEFRNSLLQLFLAAKDSPRPLLVSLAVCMAAIALHMTEWHNVIADVF 124
Query: 127 XXXXXXXXXXXXXXXXXXXX---XXDIKSTPLSQDEFECRTHELIDNIGEDVLKFLISCL 183
D + T LS +E R EL+ + G VL+ L+ +
Sbjct: 125 QACSSKDPSGRCVLQFLSVLPEEASDPRKTSLSWEELCIRVDELLRDNGPAVLELLVQYV 184
Query: 184 DRVGTEGISASK----IISCFGSWCYEFPIEQVLQVTPLINTVFQVLHTSYDTDSDSFEA 239
D V G +S +++ SW E P+++V+ +PLI F+ L D E
Sbjct: 185 DAVRASGSPSSADLGLVLTSLISWLREIPLDKVM-ASPLIELAFRSLD-----DDLLLED 238
Query: 240 AVECLCVLLRETRDAANDT-IIHALYEQLLALQQKLLPITTISDWEEYEEIMDPLTRLFV 298
AVE LC L ET+D T I LY +LL LQ KL I D E + L RLF
Sbjct: 239 AVEFLCALFNETKDVDETTDAILMLYPRLLELQPKL--IAACDDPETFRA----LGRLFA 292
Query: 299 EAGEAWCVFLAKNPALFKPLVEVILVLTCKNTDLDIVSYTFPFWFNLRQMLVLQRYAQQR 358
EAGEAW V +A+ P F PLV I + +T+L+ + +TF FW++L+QM+ L YA+ R
Sbjct: 293 EAGEAWVVLIARMPNDFLPLVNCIAQVAANDTELEAIKFTFAFWWDLKQMVELDVYAEAR 352
Query: 359 KEYQDVFINLTNGLITHLHYPET 381
+ + +++ L ++ HLHYP T
Sbjct: 353 QLFAPIYLELVRIIVRHLHYPRT 375
>7295915 [U] KOG2081 Nuclear transport regulator
Length = 914
Score = 165 bits (418), Expect = 3e-40
Identities = 201/845 (23%), Positives = 361/845 (41%), Gaps = 89/845 (10%)
Query: 10 SALICTQSVSEQEKKIQALQFLEQFQKSIEAWQICFEVLSKHEADNLQLQMFACQTLVNK 69
SAL + EQEK A ++L+ FQKSI +W I E+L H+ +L FA QT+ NK
Sbjct: 14 SALFQGNNPKEQEK---ANKWLQDFQKSIYSWTIADELL--HQKRDLHANYFAAQTMRNK 68
Query: 70 VTYDLNQVNTEL-ESFKGKLFEFIAMYEEK---IIVTQLNVALARFTIQYLDWRNPLVEI 125
+ +++ ES + L I +E+ +IVTQL++A+A + WR P+ ++
Sbjct: 69 IQNSFSELPPHTHESLRDSLITHIGQIDEQTDNVIVTQLSLAVADLALLMASWREPINDL 128
Query: 126 IXXXXXXXXXXXXXXXXXXXXXXDIKST--PLSQDEFECRTHELIDNIGEDVLKFLISCL 183
+ +I S L + E H+ +D E VLKFL CL
Sbjct: 129 LVTLAPHQCAIWPLLEVLKVLPEEIDSRYLRLGANRRE-EVHKQLDASAECVLKFLCMCL 187
Query: 184 DRVGTEGISASKI----ISCFGSWC--YEFPIEQVLQVTPLINTVFQVLHTSYDTDSDSF 237
R E + ++ + + +W + FP+ V L F++L +T
Sbjct: 188 QR---EDLDQQRVWNAALRTYSAWLVIHAFPVSHVYN-NALTQLAFRLLSLP-ETSGKLH 242
Query: 238 EAAVECLCVLL---RETRDAANDTIIHALYEQLLALQQKLLPITTISDWEEYEEIMDPLT 294
+ A EC+C LL +D A+D + A+ P E+ ++ ++
Sbjct: 243 DNATECVCALLSCINTRQDGASDPESSFEAQLFGAVCMLETPYHLSVAHEDTDKTIN-YC 301
Query: 295 RLFVEAGEAWCV-FLAKNPALFKPLVEVILVLTCK-NTDLDIVSYTFPFWFNLRQMLVLQ 352
R+F +A+ LA L + LVL C + D ++ TF W+ L + L +
Sbjct: 302 RIFTSLCDAFFYDLLADAQKPHYSLKGLDLVLLCVGHFDYEVAEITFHLWYKLSEDLFQR 361
Query: 353 RYAQQRKEYQDVFINLTNGLITHLHYPETVFENKEDEDKFKDFRYNIGDVLKSCAAVLGS 412
+ ++ L + L H E+ + F DFR + D++K A ++GS
Sbjct: 362 NEDKLTVLFRPHIERLISALFRHSQMESDHDGLIEENNNFFDFRRKVSDLIKDVAFIVGS 421
Query: 413 TVALQQPYNLINQYLQKEDPNTVWQPLEAALFAVRTMAHEISHTENVVLPQLFKQ-LCIH 471
+Q ++++ + P T W+ EAALF ++ +A I EN V+P++ + L +
Sbjct: 422 GACFKQMFHIL------QAPETTWESTEAALFIMQNVAKNILPDENEVIPKVVEAILNMS 475
Query: 472 PLTHPKLVYSTILVFSRYTEWTSKHEDLLEIQLNYIFNGFEAGQSNHDLSVAASNALMYF 531
TH + Y+ IL+ +W H + LE LN++ A Q + L+ AA+ AL
Sbjct: 476 EQTHIAVRYTAILLIGELCDWIENHPESLEAVLNFL---LYALQQKNGLAPAAAIALTSI 532
Query: 532 CQDCSSLLVNYCGQLVDFIWKIER-AVDNYSMFEMCQGLSSVINEQETAKIGGIFNSFTS 590
C C +V + LV+ ++ ++N + +G+S ++ ++
Sbjct: 533 CSACRQKMVCHISGLVEIARSLDSFQINNDVAIGLLKGISLILTRLPREQLQPALREIVG 592
Query: 591 QHNKRFDIIIQQFISNPSDPDLSAKVAHYIDLLYAILENIVPKFEYPEQGVEEPLIASIS 650
+ ++ S P + + V ++ID AI+ + P + P+ VE P +A ++
Sbjct: 593 FQLQPLAQLVDSTGSTPQKGERTDPV-YWIDRACAIIRHTNP--DVPD-NVEHPTVAILN 648
Query: 651 EHITKLINLLDAYAISNVIIVDRTMKFFR---RVFEKYHLFTQPILPAVSEFVAKGYSTS 707
+ + ++D Y S++ I++RT + R R+ K + + P + + V YS
Sbjct: 649 DAWQLISRVMDKYQ-SDLRIMERTCRLIRYGIRMVRKQAMML--VEPLIKQMVVL-YSVQ 704
Query: 708 GLGAYLWFSGSIIYVYGDDEYYPVDVQVKEAVWQFACQQCSTFFNNFKSMQTLDKFFEMV 767
+L + GSI+ V +FA KS + + EM+
Sbjct: 705 HHSCFL-YVGSIL------------------VDEFA-----------KSSECIGGLLEML 734
Query: 768 HDF------FLMCNDLLMFFPEHMMNTPVLISSLIQWDLESLPKLDNFEAYMTLIRFLDD 821
F L + L P+ ++ + LI+ + Q L + LD+ EA ++++F +
Sbjct: 735 QAFIEPTFGLLQMENGLKNNPDTLLQSS-LITPIFQCALIAC-SLDHREANSSVMKFFIN 792
Query: 822 LSSWG 826
L WG
Sbjct: 793 LLVWG 797
>Hs6912734 [U] KOG2081 Nuclear transport regulator
Length = 923
Score = 137 bits (345), Expect = 8e-32
Identities = 185/906 (20%), Positives = 368/906 (40%), Gaps = 73/906 (8%)
Query: 24 KIQALQFLEQFQKSIEAWQICFEVLSKHEADNLQLQMFACQTLVNKVTYDLNQVNTELE- 82
K +A +L + Q+S+ AW+I ++L + +++ FA QT+ K+ ++ T+
Sbjct: 27 KERASFWLGELQRSVHAWEISDQLLQIRQ--DVESCYFAAQTMKMKIQTSFYELPTDSHA 84
Query: 83 SFKGKLFEFIAMYEE--KIIVTQLNVALARFTIQYLDWRNPLVEIIXXXXXXXXXXXXXX 140
S + L I ++ +IVTQL +A+A +Q W+ + ++
Sbjct: 85 SLRDSLLTHIQNLKDLSPVIVTQLALAIADLALQMPSWKGCVQTLVEKYSNDVTSLPFLL 144
Query: 141 XXXXXXXXDIKSTPLSQDEFECRTHELIDNIG---EDVLKFLISCLDRVGTEGISASKII 197
++ S L R E+I+++ V+ L++C+++ GT+ K+
Sbjct: 145 EILTVLPEEVHSRSLRIGAN--RRTEIIEDLAFYSSTVVSLLMTCVEKAGTDEKMLMKVF 202
Query: 198 SCFGSWCYEFPIE-QVLQVTPLINTVFQVLHTSYDTDSDSFEAAVECLCVLLRETRDA-A 255
C GSW ++ + L+ +F+VL T S+ EAA +C+C L +
Sbjct: 203 RCLGSWFNLGVLDSNFMANNKLLALLFEVLQQD-KTSSNLHEAASDCVCSALYAIENVET 261
Query: 256 NDTIIHALYEQLLALQQKLLPITTISDWEEYEEIMDPLTRLFVEAGEAWCVFLAKNPAL- 314
N + L++ +L L+ E+ +++++ R+F E E + + P
Sbjct: 262 NLPLAMQLFQGVLTLETAYHMAVA---REDLDKVLN-YCRIFTELCETFLEKIVCTPGQG 317
Query: 315 FKPLVEVILVLTCK-NTDLDIVSYTFPFWFNLRQMLVLQRYAQQRKEYQDVFINLTNGLI 373
L + L+L C + ++V +F FW+ L + L ++ L + L
Sbjct: 318 LGDLRTLELLLICAGHPQYEVVEISFNFWYRLGEHLYKTNDEVIHGIFKAYIQRLLHALA 377
Query: 374 THLHYPETVFENKEDEDKFKDFRYNIGDVLKSCAAVLGSTVALQQPYNLINQYLQKEDPN 433
H E+ D F +FR + D++K ++GS Q Y+ + ++ N
Sbjct: 378 RHCQLEPDHEGVPEETDDFGEFRMRVSDLVKDLIFLIGSMECFAQLYSTL------KEGN 431
Query: 434 TVWQPLEAALFAVRTMAHEISHTENVVLPQLFKQLCIHPLT-HPKLVYSTILVFSRYTEW 492
W+ EA LF + +A + N L ++ + + P T H + Y++I + +E
Sbjct: 432 PPWEVTEAVLFIMAAIAKSVDPENNPTLVEVLEGVVRLPETVHTAVRYTSIELVGEMSEV 491
Query: 493 TSKHEDLLEIQLNYIFNGFEAGQSNHDLSVAASNALMYFCQDCSSLLVNYCGQLVDFIWK 552
++ L+ L Y+ G L+ AA+ A+ C C + + L++
Sbjct: 492 VDRNPQFLDPVLGYLMKGL----CEKPLASAAAKAIHNICSVCRDHMAQHFNGLLE---- 543
Query: 553 IERAVDNY-----SMFEMCQGLSSVINEQETAKIGGIFNSFTSQHNKRFDIIIQQFISN- 606
I R++D++ + + +G + V+ KI + S ++ Q SN
Sbjct: 544 IARSLDSFLLSPEAAVGLLKGTALVLARLPLDKITECLSELCSVQVMALKKLLSQEPSNG 603
Query: 607 -PSDPDLSAKVAHYIDLLYAILENIVPKFEYPEQGVEEPLIASISEHITKLINLLDAYAI 665
SDP + ++D L I + P E G P I E L L+ +
Sbjct: 604 ISSDPTV------FLDRLAVIFRHTNP---IVENGQTHPCQKVIQEIWPVLSETLNKHRA 654
Query: 666 SNVIIVDRTMKFFRRVFEKYHLFTQPILPAVSEFVAKGYSTSGLGAYLWFSGSIIYVYGD 725
N IV+R + R + +L + + Y +L+ ++ YG
Sbjct: 655 DN-RIVERCCRCLRFAVRCVGKGSAALLQPLVTQMVNVYHVHQHSCFLYLGSILVDEYGM 713
Query: 726 DEYYPVDVQVKEAVWQFACQQCSTFFNNFKSMQTLDKFFEMVHDFFLMCNDLLMFFPEHM 785
+E ++ + C F + L + V D F + + P +
Sbjct: 714 EE------GCRQGLLDMLQALCIPTFQLLEQQNGLQNHPDTVDDLFRLATRFIQRSPVTL 767
Query: 786 MNTPVLISSLIQWDLESLPKLDNFEAYMTLIRFLDDLSSWGFKTPPISVTSITEVPDAWR 845
+ + V+I ++QW + S LD+ +A +++RFL DL G V + E R
Sbjct: 768 LRSQVVI-PILQWAIAS-TTLDHRDANCSVMRFLRDLIHTG-------VANDHEEDFELR 818
Query: 846 CTILEQVVSKNGSNIVTALINGLVTNFDSRAHQEIISLIVKIFRLATENNNNDPSVCLEW 905
++ QV+++ G +V+ L++ ++ ++ +I ++ + P+ C W
Sbjct: 819 KELIGQVMNQLGQQLVSQLLHTCCFCLPPYTLPDVAEVLWEIMQV------DRPTFC-RW 871
Query: 906 LDSALR 911
L+++L+
Sbjct: 872 LENSLK 877
>Hs7662266 [YU] KOG2022 Nuclear transport receptor LGL2 (importin beta
superfamily)
Length = 963
Score = 108 bits (269), Expect = 5e-23
Identities = 146/747 (19%), Positives = 306/747 (40%), Gaps = 71/747 (9%)
Query: 22 EKKIQALQFLEQFQKSIEAWQICFEVLSKHEADNLQLQMFACQTLVNKVTYDLNQVNTE- 80
E K A ++L Q Q S +AW +++L + ++Q F L K++ + + T+
Sbjct: 40 ENKNLAQKWLMQAQVSPQAWHFSWQLLQPDKVP--EIQYFGASALHIKISRYWSDIPTDQ 97
Query: 81 LESFKGKLFEFIAMYEE--KIIVTQLNVALARFTIQYLD--WRNPLVEIIXXXXXXXXXX 136
ES K +LF I + KI++T+L VALA + + W + +++
Sbjct: 98 YESLKAQLFTQITRFASGSKIVLTRLCVALASLALSMMPDAWPCAVADMVRLFQAEDSPV 157
Query: 137 X------XXXXXXXXXXXDIKSTPLSQDEFECRTHELIDNIGEDVLKFLISCLDRVGTEG 190
+ +++ L Q L G V L L + +
Sbjct: 158 DGQGRCLALLELLTVLPEEFQTSRLPQYRKGLVRTSLAVECGA-VFPLLEQLLQQPSSPS 216
Query: 191 ISASKIISCFGSWCY-EFPIEQVLQVTPLINTVFQVLHTSYDTDSDSFEAAVECLCVLLR 249
K++ CF SW E P++ LI F L DS+ F+++VE + +
Sbjct: 217 CVRQKVLKCFSSWVQLEVPLQDC---EALIQAAFAALQ-----DSELFDSSVEAIVNAIS 268
Query: 250 ETRDAANDTIIHALYEQLLALQQKLLPITTISDWEEYEEIM-------DPLTRLFVEAGE 302
+ + L +L LQ++L D E I + +R ++ E
Sbjct: 269 QPDAQRYVNTLLKLIPLVLGLQEQLRQAVQNGDMETSHGICRIAVALGENHSRALLDQVE 328
Query: 303 AWCVFLAKNPALFKPLVEVILVLTCKNTDLDI----VSYTFPFWFNLRQMLV---LQRYA 355
W FLA LV +I+ T + S T FW+ L+ ++ ++ A
Sbjct: 329 HWQSFLA--------LVNMIMFCTGIPGHYPVNETTSSLTLTFWYTLQDDILSFEAEKQA 380
Query: 356 QQRKEYQDVFINLTNGLITHLHYP---ETVFENKEDEDKFKDFRYNIGDVLKSCAAVLGS 412
++ Y+ V+ L + L+ +P E F + +++++F+ +R +I D L +LG+
Sbjct: 381 VYQQVYRPVYFQLVDVLLHKAQFPSDEEYGFWSSDEKEQFRIYRVDISDTLMYVYEMLGA 440
Query: 413 TVALQQPYNLINQYLQKEDPNTVWQPLEAALFAVRTMAHEISHTENVVLPQLFKQLCIHP 472
+ L Y+ + + L + WQ EA L+ +++A I + V+P L +
Sbjct: 441 EL-LSNLYDKLGRLLTSSEEPYSWQHTEALLYGFQSIAETIDVNYSDVVPGLIGLIPRIS 499
Query: 473 LTHPKLVYSTILVFSRYTEWTSKHEDLLEIQLNYIFNGFEAGQSNHDLSVAASNALMYFC 532
+++ +L + + +EW + H ++ L + + N +LSV++ + L C
Sbjct: 500 ISNVQLADTVMFTIGALSEWLADHPVMINSVLPLVLHAL----GNPELSVSSVSTLKKIC 555
Query: 533 QDCSSLLVNYCGQLVDFIWKI--ERAVDNYSMFEMCQGLSSVINEQETAKIGGIFNSFTS 590
++C L Y +V + ++ + Q L +++ + +I +S S
Sbjct: 556 RECKYDLPPYAANIVAVSQDVLMKQIHKTSQCMWLMQALGFLLSALQVEEILKNLHSLIS 615
Query: 591 QHNKRFDIIIQQFISNPSDPDLSAKVAHYIDLLYAILENI-VPKFEYPEQGVE------- 642
+ ++ + + ++ I NPS+ + H + LL + + + E +G E
Sbjct: 616 PYIQQLEKLAEE-IPNPSN---KLAIVHILGLLSNLFTTLDISHHEDDHEGPELRKLPVP 671
Query: 643 ---EPLIASISEHITKLINLLDAYAISNVIIVDRTMKFFRRVFEKYHLFTQPILPAVSEF 699
P++ + + + +LI + + +++ +V+ F + + P++P + E
Sbjct: 672 QGPNPVVV-VLQQVFQLIQKVLSKWLNDAQVVEAVCAIFEKSVKTLLDDFAPMVPQLCEM 730
Query: 700 VAKGYSTSGLGAYLWFSGSIIYVYGDD 726
+ + YST + L + +++++ +
Sbjct: 731 LGRMYSTIPQASALDLTRQLVHIFAHE 757
>At5g62600 [U] KOG2081 Nuclear transport regulator
Length = 572
Score = 85.9 bits (211), Expect = 3e-16
Identities = 129/568 (22%), Positives = 233/568 (40%), Gaps = 68/568 (11%)
Query: 8 IKSALICTQSVSEQEKKIQALQFLEQFQKSIEAWQICFEVLSKHEADNLQLQMFA----C 63
+K AL + ++ A ++L+ FQ +++AWQ + S + + + C
Sbjct: 7 VKEALNALYHHPDDTVRVHADRWLQNFQGTLDAWQKS-RIFSTSKFNCALFPVAGLRSMC 65
Query: 64 QTLVNKVTYDLNQVNT-ELESFKGKLFEFIAMYEE--KIIVTQLNVALARFTIQY--LDW 118
+TL +KV D ++ + + L + + + + TQ+++A+A + DW
Sbjct: 66 KTLRSKVQRDFEELPPGAFQKLRQSLTTLLKKFHKGPPKVRTQISIAVAALAVHVPAADW 125
Query: 119 RNPLVEI-------IXXXXXXXXXXXXXXXXXXXXXXDIKSTPLSQDEFECRTHELIDNI 171
+ + + I + P + +FE EL +
Sbjct: 126 GDGGIISWLRDEMHMHPEYVPGFLELLTVLPEETFNYKIAARPDRRRQFE---KELTSQM 182
Query: 172 GEDVLKFLISCLDRVGTEGISASK--IISCFGSWC---YEFPIEQVLQVTPLINTVFQVL 226
E L L +CL IS K ++ F SW + P VL PL++
Sbjct: 183 -EAALSILSACLK------ISELKEQVLEAFASWLRLRHGIP-GTVLACHPLVHAAL--- 231
Query: 227 HTSYDTDSDSFEAAVECLCVLLRETRD------AANDTIIHALYEQLLALQQKLLPITTI 280
+S + D S EA+V + L+ T +A +I + Q+L+LQ L
Sbjct: 232 -SSLNCDPLS-EASVNVISELIHHTASPSSGGISAQTPLIQVIVPQILSLQAHL------ 283
Query: 281 SDWEEYEEIMDPLTRLFVEAGEAWCVFLAKNPALFKPLVEVILVLTCKNTDLDIVSYTFP 340
D + EE + + RLF + G+++ +A +V +L +T + + DI S TF
Sbjct: 284 RDSSKDEEDVKAIGRLFADVGDSYVELIATGSDEPMVIVHALLEVTA-HPEFDIASMTFN 342
Query: 341 FWFNLRQMLVLQR-YAQQRKE-------------YQDVFINLTNGLITHLHYPETVFE-N 385
FW +L+ ML + Y+ E +Q + +L + + + YPE +
Sbjct: 343 FWHSLQLMLTKRESYSSLGSEASIEVERNRRLHIFQPAYQSLVSLVGFRVQYPEDYQGLS 402
Query: 386 KEDEDKFKDFRYNIGDVLKSCAAVLGSTVALQQPY-NLINQYLQKEDPNTVWQPLEAALF 444
ED +FK RY + DVL A +LG L+ Y L+ Q + W+P EA LF
Sbjct: 403 YEDLKEFKQTRYAVADVLIDAALILGGDTTLKILYMKLLEANAQTGNNFQDWRPAEAILF 462
Query: 445 AVRTMAHEISHTENVVLPQLFKQLCIHPLTHPKLVYSTILVFSRYTEWTSKHEDLLEIQL 504
+ +++ +S E V+PQ+ L P +L+ + L+ Y++W + + I
Sbjct: 463 CIWAISNYVSVVEAEVMPQVMALLQNLP-QQAQLLQTACLLVGAYSKWLNAAPASVSILP 521
Query: 505 NYIFNGFEAGQSNHDLSVAASNALMYFC 532
+ I ++ D + AA+ A + C
Sbjct: 522 SIIRILMSGMGTSEDCAAAAALAFRHTC 549
>7300343 [YU] KOG2022 Nuclear transport receptor LGL2 (importin beta
superfamily)
Length = 971
Score = 71.6 bits (174), Expect = 5e-12
Identities = 141/778 (18%), Positives = 294/778 (37%), Gaps = 119/778 (15%)
Query: 29 QFLEQFQKSIEAWQICFEVLSKHEADNLQLQMFACQTLVNKVTYDLNQVNTE-LESFKGK 87
++L + S +AWQ ++++ ++ ++Q F TL +K+ ++V E E K K
Sbjct: 29 EWLTDAEASPQAWQFSWQLMQLGKSQ--EVQFFGAITLHSKLMKHWHEVPPENREELKQK 86
Query: 88 LFEFIAMYE--EKIIVTQLNVALARFTIQYL-DWRNPLVEIIXXXXXXXXXXXXXXX--- 141
+ E I + KI++ +L ++L + + L +W + E+I
Sbjct: 87 ILESIVRFAGGPKIVLNRLCISLGAYIVHMLGEWPGAIEEVINTFQNQRMPNVSADVQLW 146
Query: 142 ------XXXXXXXDIKSTPLSQDEFECRTHELIDNIGEDVLKFLISCLDRV-GTEGIS-A 193
+ T + + + + + V ++L ++RV E S
Sbjct: 147 IMLEVLTAIPEEAQVIHTSVKRVVLRAEIAKRVQLVIHTVERYLKLQMNRVWDAEAYSNM 206
Query: 194 SKIISCFGSWCYE--FPIEQVLQVTPLINTVFQVLHTSYDTDSDSFEAAVECLCVLLRET 251
++ + C G+W + IE + +T ++ +V+H Y A C+ E
Sbjct: 207 NRAVKCVGTWIKNIGYTIEGCVTITAVL---LEVVHKCY---WPCIHAGDGCMTADENEL 260
Query: 252 RDAANDTIIHALYEQ-----------LLALQQKLLPITTISDWE---EYEEIMDPLTRLF 297
++ T+++ + + L+ + L T ++W+ + E+I+ + LF
Sbjct: 261 AESCLKTMVNIIIQPDCHNYPKTAFVLIKMFLDSLSEITKTEWKRENDNEDIIVHIYMLF 320
Query: 298 VEAGEAWCVFLAKNPALFKPLVEVIL------VLTCKN------TDLDIVSYTFPFWFNL 345
V + E L P + +++ +L C + + + FW+ L
Sbjct: 321 VSSVERHSTLLLSGITSADPELSILVHRIVQEILHCTDKPGIYPVEESCSTMALAFWYML 380
Query: 346 R-QMLVLQRYAQQRK--EY-QDVFINLTNGLITHLHYPETVFENK---EDEDKFKDFRYN 398
+ ++ + Q+ K EY + ++ +LT L+ P+ K +D + F+ +R +
Sbjct: 381 QDEVFAMSNDEQKHKCWEYIKPLYAHLTRILVRKSEQPDEKSLAKWSSDDLECFRCYRQD 440
Query: 399 IGDVLKSCAAVLGSTVALQQPYNLINQYLQKEDPNTVWQPLEAALFAVRTMAHEISHTEN 458
I D C VL + L + T W LEA +++ +++A E
Sbjct: 441 ISDTFMYCYDVLNDYILEILAAMLDEAIADLQRHPTHWTKLEACIYSFQSVAEHFGGEEK 500
Query: 459 VVLPQLFKQLCIHPL--THPKLVYSTILVFSRYTEWTSKHEDLLEIQLNYIFNGFEAGQS 516
+P+L + L P + KL+ + + Y W ++ + +N + G
Sbjct: 501 RQIPRLMRVLAEIPYEKLNVKLLGTALETMGSYCNWLMENPAYIPPAINLLVRGL----- 555
Query: 517 NHDLSVAASNALMYFCQDCSSLLVNYCGQLVDF------IWKIERAVDNYSMFEMCQGLS 570
N +S A+ L C+DC L Y L++ +++ + MF + + L
Sbjct: 556 NSSMSAQATLGLKELCRDCQLQLKPYADPLLNACHASLNTGRMKNSDSVRLMFSIGK-LM 614
Query: 571 SVINEQETAKIGGIFNSFTSQHNKRFDIIIQQFISNPSDPDLSAKVAHYIDLLYAILENI 630
S++ +E K + S + I Q P+ + + I L++ L
Sbjct: 615 SLLRPEEIPK---YLDIIVSPCFEELQAICQADSKTPAARIRTIFRLNMISTLFSSLNT- 670
Query: 631 VPKFEYPEQGVEEPLIASISEHITKLINLLDAYAISNVIIVDRTMKFFRRVFEKY----- 685
+ EQ ++P++ + ++++ RTM F+R+ E +
Sbjct: 671 ----DVDEQATDQPIVQPV------------------LLVMQRTMPIFKRIAEMWVEEID 708
Query: 686 ----------HLFT------QPILPAVSEFVAKGYSTSGLGAYLWFSGSIIYVYGDDE 727
H T QP+L + F+ + T L S + I ++ DE
Sbjct: 709 VLEAACSAMKHAITNLRSSFQPMLQDLCLFIVASFQTRCCAPTLEISKTAIVMFFKDE 766
>CE11000 [U] KOG2081 Nuclear transport regulator
Length = 980
Score = 67.4 bits (163), Expect = 1e-10
Identities = 102/508 (20%), Positives = 200/508 (39%), Gaps = 72/508 (14%)
Query: 102 TQLNVALARFTIQYLDWRNPLVEIIXXXXXXXXXXXXXXXXXXXXXXDIKSTPLSQDEFE 161
TQL +A+A IQ W N + E++ + + E
Sbjct: 70 TQLCLAIADLYIQVPTWNNWIFELLNQCQALEGDRTVMTLTLLQVFPE--EVEQIRGVGE 127
Query: 162 CRTHELIDNIG---EDVLKFLISCLDRVGTEGISASKIISCFGSWCYEFPIE-QVLQVTP 217
R H + + + + ++ FL L++ + ++ C S + +P
Sbjct: 128 NRRHAIRNELAACEQPMITFLSHVLEKFHSNADVLKRVFKCLESNLQNHQMRTDHFAASP 187
Query: 218 LINTVFQVLHTSYDTDSDSFEAAVECLCVLLRETRDAANDTIIHALYE-QLLALQQKLLP 276
LI+ +F V+ S D S CL + A + I+ ALY + L + +KL
Sbjct: 188 LISMIFHVI-ASIDPIIPS------CL-------HETATNCIVQALYRVEDLEMHRKLAE 233
Query: 277 ------ITTISDWEEYEEIMD-------------PLTRLFVEAGEAWCVFLAK----NPA 313
I+ +S +E+ +++ D + R+FVE E++ V + +PA
Sbjct: 234 VVHRGVISLVSAFEKAQQVEDFDRLQVAEKWRNLNIARIFVEMVESFYVQIVNEANPDPA 293
Query: 314 LFKPLVEV-ILVLTCKNTD---------LDIVSYTFPFWFNLRQMLVL---QRYAQQRKE 360
L +L+L K+ D L ++ +F W+ + + L +Y + +
Sbjct: 294 AIGSLACFELLLLVAKHHDWALKIAIFLLQLIEMSFNVWYRITEELFKYDDDQYIGRFRP 353
Query: 361 YQDVFINLTNGLITHLHYPETVFENKEDE-DKFKDFRYNIGDVLKSCAAVLGSTVALQQP 419
Y + FI L H ++ DE +F +FR + L+ ++ S +Q
Sbjct: 354 YAEKFIQC---LYEHCKLDADDVDDLLDETSEFGEFRLKAVEALRDVVFIVNSDKCIQMM 410
Query: 420 YNLINQYLQKEDPNTVWQPLEAALFAVRTMAHEISHTENVVLPQLFKQLCIHPL-THPKL 478
+ + + K PN W+ E+ALF + + + + +P++ + +C P+ + P L
Sbjct: 411 HQKLIECCHK--PNASWEESESALFVMSAVVQNLLPESDTNMPEVLQLICSLPVQSPPAL 468
Query: 479 VYSTILVFSRYTEWTSKHEDLLEIQLNYIFNGFEAGQSNHDLSVAASNALMY--FCQDCS 536
+ +++ + S +W +H +LLE + + Q D A+ AL + C+
Sbjct: 469 IATSLSLISDLNDWFEQHSNLLEPVVRWTL------QFATDTRYASHVALCFDRITSKCA 522
Query: 537 SLLVNYCGQLVDFIWKIERAVDNYSMFE 564
+ QL+ I +E+ N + E
Sbjct: 523 VQMTPLLPQLLTLIGVLEQTTTNGAKVE 550
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.323 0.138 0.413
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 55,555,957
Number of Sequences: 60738
Number of extensions: 2363260
Number of successful extensions: 6042
Number of sequences better than 1.0e-05: 8
Number of HSP's better than 0.0 without gapping: 2
Number of HSP's successfully gapped in prelim test: 6
Number of HSP's that attempted gapping in prelim test: 6004
Number of HSP's gapped (non-prelim): 13
length of query: 961
length of database: 30,389,216
effective HSP length: 116
effective length of query: 845
effective length of database: 23,343,608
effective search space: 19725348760
effective search space used: 19725348760
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)