ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactI0659 check: MH T KOG0660 Signal transduction mechanisms Mitogen-activated protein kinase
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactI0659 218592 219677 362
(362 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YGR040w [T] KOG0660 Mitogen-activated protein kinase 582 e-166
SPAC31G5.09c [T] KOG0660 Mitogen-activated protein kinase 409 e-114
YBL016w [T] KOG0660 Mitogen-activated protein kinase 394 e-109
Hs20986529 [T] KOG0660 Mitogen-activated protein kinase 351 1e-96
Hs20986531 [T] KOG0660 Mitogen-activated protein kinase 350 1e-96
Hs20562757 [T] KOG0660 Mitogen-activated protein kinase 340 1e-93
CE24971 [T] KOG0660 Mitogen-activated protein kinase 337 1e-92
CE01583 [T] KOG0660 Mitogen-activated protein kinase 337 1e-92
Hs20986501 [T] KOG0660 Mitogen-activated protein kinase 325 8e-89
Hs20986497 [T] KOG0660 Mitogen-activated protein kinase 325 8e-89
At3g45640 [T] KOG0660 Mitogen-activated protein kinase 319 3e-87
At2g43790 [T] KOG0660 Mitogen-activated protein kinase 318 8e-87
SPAC24B11.06c [T] KOG0660 Mitogen-activated protein kinase 317 2e-86
SPBC119.08 [T] KOG0660 Mitogen-activated protein kinase 316 4e-86
7298087 [T] KOG0660 Mitogen-activated protein kinase 315 7e-86
At1g59580 [T] KOG0660 Mitogen-activated protein kinase 308 6e-84
7301110 [T] KOG0660 Mitogen-activated protein kinase 308 6e-84
At2g18170 [T] KOG0660 Mitogen-activated protein kinase 306 2e-83
At3g59790 [T] KOG0660 Mitogen-activated protein kinase 306 3e-83
At1g10210 [T] KOG0660 Mitogen-activated protein kinase 306 4e-83
Hs20986512 [T] KOG0660 Mitogen-activated protein kinase 302 4e-82
YLR113w [T] KOG0660 Mitogen-activated protein kinase 301 8e-82
At1g07880 [T] KOG0660 Mitogen-activated protein kinase 301 8e-82
At4g36450 [T] KOG0660 Mitogen-activated protein kinase 300 2e-81
YHR030c [T] KOG0660 Mitogen-activated protein kinase 299 4e-81
At4g01370 [T] KOG0660 Mitogen-activated protein kinase 298 6e-81
Hs20128774 [T] KOG0660 Mitogen-activated protein kinase 296 4e-80
Hs4503069 [T] KOG0660 Mitogen-activated protein kinase 295 5e-80
CE06686 [T] KOG0660 Mitogen-activated protein kinase 289 4e-78
At4g11330 [T] KOG0660 Mitogen-activated protein kinase 289 5e-78
At2g46070 [T] KOG0660 Mitogen-activated protein kinase 286 4e-77
Hs4506085 [T] KOG0660 Mitogen-activated protein kinase 275 1e-73
At1g18150 [T] KOG0660 Mitogen-activated protein kinase 273 3e-73
Hs4506785 [T] KOG0660 Mitogen-activated protein kinase 273 4e-73
At3g18040 [T] KOG0660 Mitogen-activated protein kinase 271 8e-73
At2g42880 [T] KOG0660 Mitogen-activated protein kinase 270 3e-72
At3g14720 [T] KOG0660 Mitogen-activated protein kinase 269 5e-72
At5g19010 [T] KOG0660 Mitogen-activated protein kinase 268 7e-72
At1g53510 [T] KOG0660 Mitogen-activated protein kinase 268 9e-72
CE06762 [T] KOG0660 Mitogen-activated protein kinase 263 3e-70
At1g73670 [T] KOG0660 Mitogen-activated protein kinase 263 4e-70
YKL161c [T] KOG0660 Mitogen-activated protein kinase 260 3e-69
At2g01450 [T] KOG0660 Mitogen-activated protein kinase 253 2e-67
YPR054w [T] KOG0660 Mitogen-activated protein kinase 251 1e-66
Hs20986499 [T] KOG0660 Mitogen-activated protein kinase 250 2e-66
Hs20986514 [T] KOG0660 Mitogen-activated protein kinase 249 4e-66
7295173 [T] KOG0664 Nemo-like MAPK-related serine/threonine prot... 239 4e-63
Hs7706445 [T] KOG0664 Nemo-like MAPK-related serine/threonine pr... 238 1e-62
Hs20986516 [T] KOG0660 Mitogen-activated protein kinase 238 1e-62
CE17062 [T] KOG0660 Mitogen-activated protein kinase 238 1e-62
CE02602_1 [T] KOG0660 Mitogen-activated protein kinase 235 7e-62
Hs21237745 [T] KOG0665 Jun-N-terminal kinase (JNK) 234 1e-61
Hs21237742 [T] KOG0665 Jun-N-terminal kinase (JNK) 234 1e-61
CE29020 [T] KOG0660 Mitogen-activated protein kinase 231 1e-60
Hs4506081 [T] KOG0665 Jun-N-terminal kinase (JNK) 226 5e-59
Hs20986510 [T] KOG0665 Jun-N-terminal kinase (JNK) 226 5e-59
Hs20986506 [T] KOG0665 Jun-N-terminal kinase (JNK) 226 5e-59
CE29478 [T] KOG0664 Nemo-like MAPK-related serine/threonine prot... 224 2e-58
CE29477 [T] KOG0664 Nemo-like MAPK-related serine/threonine prot... 224 2e-58
CE29476 [T] KOG0664 Nemo-like MAPK-related serine/threonine prot... 224 2e-58
HsM20070143 [T] KOG0665 Jun-N-terminal kinase (JNK) 223 3e-58
Hs4506095 [T] KOG0665 Jun-N-terminal kinase (JNK) 223 3e-58
Hs21237739 [T] KOG0665 Jun-N-terminal kinase (JNK) 223 3e-58
Hs21237736 [T] KOG0665 Jun-N-terminal kinase (JNK) 223 3e-58
Hs20986523 [T] KOG0665 Jun-N-terminal kinase (JNK) 223 3e-58
Hs20986521 [T] KOG0665 Jun-N-terminal kinase (JNK) 222 6e-58
Hs20986519 [T] KOG0665 Jun-N-terminal kinase (JNK) 222 6e-58
CE29318 [T] KOG0660 Mitogen-activated protein kinase 222 8e-58
Hs4506089 [T] KOG0660 Mitogen-activated protein kinase 217 2e-56
7297631 [T] KOG0665 Jun-N-terminal kinase (JNK) 213 3e-55
CE27574 [T] KOG0665 Jun-N-terminal kinase (JNK) 213 4e-55
CE29466 [T] KOG0665 Jun-N-terminal kinase (JNK) 210 3e-54
CE17305 [T] KOG0665 Jun-N-terminal kinase (JNK) 209 4e-54
Hs4506091 [T] KOG0660 Mitogen-activated protein kinase 207 2e-53
Hs20502986 [T] KOG0660 Mitogen-activated protein kinase 206 6e-53
7291043 [T] KOG0660 Mitogen-activated protein kinase 205 7e-53
CE27220 [T] KOG0660 Mitogen-activated protein kinase 198 1e-50
SPAC2F3.15 [D] KOG0600 Cdc2-related protein kinase 196 4e-50
YPL031c [R] KOG0594 Protein kinase PCTAIRE and related kinases 189 4e-48
At3g48750 [R] KOG0594 Protein kinase PCTAIRE and related kinases 188 9e-48
SPBC18H10.15 [R] KOG0663 Protein kinase PITSLRE and related kinases 186 6e-47
At5g26751 [G] KOG0658 Glycogen synthase kinase-3 185 1e-46
At1g67580 [R] KOG0663 Protein kinase PITSLRE and related kinases 185 1e-46
SPBC11B10.09 [R] KOG0594 Protein kinase PCTAIRE and related kinases 184 2e-46
Hs4502709 [R] KOG0594 Protein kinase PCTAIRE and related kinases 183 4e-46
Hs16936528 [R] KOG0594 Protein kinase PCTAIRE and related kinases 182 7e-46
Hs4557439 [R] KOG0594 Protein kinase PCTAIRE and related kinases 181 1e-45
Hs4502743 [DKL] KOG0659 Cdk activating kinase (CAK)/RNA polymera... 180 3e-45
At3g05840 [G] KOG0658 Glycogen synthase kinase-3 180 3e-45
Hs4826675 [UT] KOG0662 Cyclin-dependent kinase CDK5 179 6e-45
7300773 [DKL] KOG0659 Cdk activating kinase (CAK)/RNA polymerase... 178 1e-44
CE26422 [D] KOG0600 Cdc2-related protein kinase 178 1e-44
7290565 [DKL] KOG0659 Cdk activating kinase (CAK)/RNA polymerase... 176 4e-44
SPCC16C4.11 [R] KOG0594 Protein kinase PCTAIRE and related kinases 175 8e-44
SPAC1687.15 [G] KOG0658 Glycogen synthase kinase-3 175 1e-43
At5g63370 [R] KOG0663 Protein kinase PITSLRE and related kinases 174 1e-43
At3g61160 [G] KOG0658 Glycogen synthase kinase-3 174 2e-43
CE03811 [R] KOG0663 Protein kinase PITSLRE and related kinases 173 3e-43
At2g30980 [G] KOG0658 Glycogen synthase kinase-3 173 3e-43
Hs20986508 [T] KOG0665 Jun-N-terminal kinase (JNK) 173 4e-43
7303051 [UT] KOG0662 Cyclin-dependent kinase CDK5 173 4e-43
Hs4505649 [R] KOG0594 Protein kinase PCTAIRE and related kinases 172 9e-43
7297578 [T] KOG0661 MAPK related serine/threonine protein kinase 172 9e-43
At5g14640 [G] KOG0658 Glycogen synthase kinase-3 171 2e-42
Hs4507281 [R] KOG0593 Predicted protein kinase KKIAMRE 171 2e-42
At4g18710 [G] KOG0658 Glycogen synthase kinase-3 171 2e-42
At4g00720 [G] KOG0658 Glycogen synthase kinase-3 171 2e-42
At1g06390 [G] KOG0658 Glycogen synthase kinase-3 171 2e-42
At1g73690 [DKL] KOG0659 Cdk activating kinase (CAK)/RNA polymera... 170 3e-42
At1g20930 [R] KOG0594 Protein kinase PCTAIRE and related kinases 170 3e-42
7303804 [R] KOG0663 Protein kinase PITSLRE and related kinases 170 3e-42
Hs4505569 [R] KOG0593 Predicted protein kinase KKIAMRE 169 4e-42
Hs5453860 [R] KOG0594 Protein kinase PCTAIRE and related kinases 169 6e-42
Hs15011928 [R] KOG0594 Protein kinase PCTAIRE and related kinases 169 6e-42
At5g64960 [D] KOG0600 Cdc2-related protein kinase 169 6e-42
At1g57870 [G] KOG0658 Glycogen synthase kinase-3 169 8e-42
At1g09840 [G] KOG0658 Glycogen synthase kinase-3 169 8e-42
At5g10270 [D] KOG0600 Cdc2-related protein kinase 168 1e-41
At2g38620 [R] KOG0594 Protein kinase PCTAIRE and related kinases 168 1e-41
7297680 [R] KOG0594 Protein kinase PCTAIRE and related kinases 168 1e-41
At4g13020 [T] KOG0661 MAPK related serine/threonine protein kinase 167 2e-41
CE29073 [R] KOG0594 Protein kinase PCTAIRE and related kinases 167 2e-41
CE06779 [R] KOG0594 Protein kinase PCTAIRE and related kinases 167 2e-41
At1g18040 [DKL] KOG0659 Cdk activating kinase (CAK)/RNA polymera... 167 3e-41
At1g76540 [R] KOG0594 Protein kinase PCTAIRE and related kinases 166 4e-41
YBR160w [R] KOG0594 Protein kinase PCTAIRE and related kinases 166 6e-41
SPBC19F8.07 [DKL] KOG0659 Cdk activating kinase (CAK)/RNA polyme... 166 6e-41
Hs7657498 [T] KOG0661 MAPK related serine/threonine protein kinase 166 6e-41
Hs4502741 [R] KOG0594 Protein kinase PCTAIRE and related kinases 165 1e-40
Hs21040235 [R] KOG0594 Protein kinase PCTAIRE and related kinases 165 1e-40
CE18009 [R] KOG0594 Protein kinase PCTAIRE and related kinases 164 1e-40
Hs16357498 [R] KOG0663 Protein kinase PITSLRE and related kinases 164 2e-40
Hs16357486 [R] KOG0663 Protein kinase PITSLRE and related kinases 164 2e-40
Hs16357484 [R] KOG0663 Protein kinase PITSLRE and related kinases 164 2e-40
Hs16357482 [R] KOG0663 Protein kinase PITSLRE and related kinases 164 2e-40
Hs16357480 [R] KOG0663 Protein kinase PITSLRE and related kinases 164 2e-40
Hs16357496 [R] KOG0663 Protein kinase PITSLRE and related kinases 164 2e-40
Hs16357494 [R] KOG0663 Protein kinase PITSLRE and related kinases 164 2e-40
Hs16357492 [R] KOG0663 Protein kinase PITSLRE and related kinases 164 2e-40
Hs16332372 [R] KOG0663 Protein kinase PITSLRE and related kinases 164 2e-40
Hs16332370 [R] KOG0663 Protein kinase PITSLRE and related kinases 164 2e-40
Hs16332368 [R] KOG0663 Protein kinase PITSLRE and related kinases 164 2e-40
Hs16332366 [R] KOG0663 Protein kinase PITSLRE and related kinases 164 2e-40
Hs16332364 [R] KOG0663 Protein kinase PITSLRE and related kinases 164 2e-40
Hs16332362 [R] KOG0663 Protein kinase PITSLRE and related kinases 164 2e-40
Hs16332360 [R] KOG0663 Protein kinase PITSLRE and related kinases 164 2e-40
Hs16332358 [R] KOG0663 Protein kinase PITSLRE and related kinases 164 2e-40
Hs10835055 [R] KOG0663 Protein kinase PITSLRE and related kinases 164 2e-40
At1g66750 [DKL] KOG0659 Cdk activating kinase (CAK)/RNA polymera... 164 2e-40
7302908 [R] KOG0594 Protein kinase PCTAIRE and related kinases 164 2e-40
CE21213 [UT] KOG0662 Cyclin-dependent kinase CDK5 163 3e-40
Hs7706549 [D] KOG0600 Cdc2-related protein kinase 163 4e-40
At3g54180 [R] KOG0594 Protein kinase PCTAIRE and related kinases 163 4e-40
SPBC32H8.10 [D] KOG0600 Cdc2-related protein kinase 162 5e-40
Hs14110390 [D] KOG0600 Cdc2-related protein kinase 162 5e-40
Hs14110387 [D] KOG0600 Cdc2-related protein kinase 162 5e-40
Hs16160923 [R] KOG0594 Protein kinase PCTAIRE and related kinases 162 9e-40
7292375 [R] KOG0594 Protein kinase PCTAIRE and related kinases 162 9e-40
7300650 [R] KOG0594 Protein kinase PCTAIRE and related kinases 160 2e-39
YPR161c [D] KOG0600 Cdc2-related protein kinase 160 3e-39
HsM4504163 [G] KOG0658 Glycogen synthase kinase-3 160 3e-39
7296451 [D] KOG0600 Cdc2-related protein kinase 160 3e-39
Hs11496279 [T] KOG0661 MAPK related serine/threonine protein kinase 160 4e-39
CE00315 [R] KOG0594 Protein kinase PCTAIRE and related kinases 160 4e-39
At5g45430 [T] KOG0661 MAPK related serine/threonine protein kinase 160 4e-39
7290342 [G] KOG0658 Glycogen synthase kinase-3 160 4e-39
CE21401 [G] KOG0658 Glycogen synthase kinase-3 159 6e-39
CE12408 [T] KOG0661 MAPK related serine/threonine protein kinase 159 6e-39
SPBC8D2.01 [G] KOG0658 Glycogen synthase kinase-3 159 8e-39
Hs6912584 [R] KOG0594 Protein kinase PCTAIRE and related kinases 159 8e-39
ECU08g1920 [R] KOG0594 Protein kinase PCTAIRE and related kinases 158 1e-38
YDL108w [DKL] KOG0659 Cdk activating kinase (CAK)/RNA polymerase... 158 1e-38
Hs7706059 [R] KOG0593 Predicted protein kinase KKIAMRE 158 1e-38
Hs4502747 [D] KOG0669 Cyclin T-dependent kinase CDK9 158 1e-38
CE29612 [R] KOG0594 Protein kinase PCTAIRE and related kinases 157 2e-38
Hs7662388 [T] KOG0661 MAPK related serine/threonine protein kinase 157 3e-38
Hs22051130 [G] KOG0658 Glycogen synthase kinase-3 157 3e-38
Hs11995474 [G] KOG0658 Glycogen synthase kinase-3 157 3e-38
YMR139w [G] KOG0658 Glycogen synthase kinase-3 155 1e-37
Hs7705551 [T] KOG0661 MAPK related serine/threonine protein kinase 155 1e-37
Hs4758652 [R] KOG0593 Predicted protein kinase KKIAMRE 154 3e-37
CE01761 [R] KOG0663 Protein kinase PITSLRE and related kinases 154 3e-37
7296346 [R] KOG0663 Protein kinase PITSLRE and related kinases 154 3e-37
Hs4502735 [R] KOG0594 Protein kinase PCTAIRE and related kinases 153 4e-37
At1g33770 [D] KOG0600 Cdc2-related protein kinase 152 6e-37
SPBPI064 [G] KOG0658 Glycogen synthase kinase-3 152 7e-37
At5g63610 [K] KOG0666 Cyclin C-dependent kinase CDK8 152 7e-37
7297009 [R] KOG0593 Predicted protein kinase KKIAMRE 152 7e-37
7291442 [D] KOG0669 Cyclin T-dependent kinase CDK9 152 1e-36
At1g09600 [D] KOG0600 Cdc2-related protein kinase 151 1e-36
Hs21361340 [G] KOG0658 Glycogen synthase kinase-3 151 2e-36
Hs4503095 [TDK] KOG0668 Casein kinase II alpha subunit 150 2e-36
At4g22940 [D] KOG0600 Cdc2-related protein kinase 150 2e-36
At5g44290 [D] KOG0600 Cdc2-related protein kinase 150 3e-36
At1g53050 [D] KOG0600 Cdc2-related protein kinase 150 4e-36
At1g03740 [D] KOG0600 Cdc2-related protein kinase 149 5e-36
At5g50860 [D] KOG0600 Cdc2-related protein kinase 149 8e-36
Hs4502731 [R] KOG0663 Protein kinase PITSLRE and related kinases 148 1e-35
At4g19110 [T] KOG0661 MAPK related serine/threonine protein kinase 148 1e-35
Hs16950647 [R] KOG0663 Protein kinase PITSLRE and related kinases 148 1e-35
At3g05050 [D] KOG0600 Cdc2-related protein kinase 147 2e-35
At1g71530 [D] KOG0600 Cdc2-related protein kinase 147 2e-35
CE20258 [R] KOG0593 Predicted protein kinase KKIAMRE 147 3e-35
CE11556 [DKL] KOG0659 Cdk activating kinase (CAK)/RNA polymerase... 147 3e-35
Hs4503097 [TDK] KOG0668 Casein kinase II alpha subunit 146 4e-35
At4g10010 [D] KOG0600 Cdc2-related protein kinase 146 4e-35
YKL139w [D] KOG0600 Cdc2-related protein kinase 146 5e-35
At5g39420 [D] KOG0600 Cdc2-related protein kinase 145 7e-35
At1g57700 [D] KOG0600 Cdc2-related protein kinase 145 7e-35
At1g54610 [D] KOG0600 Cdc2-related protein kinase 145 7e-35
Hs17461944 [R] KOG0593 Predicted protein kinase KKIAMRE 145 9e-35
At3g50000 [TDK] KOG0668 Casein kinase II alpha subunit 145 9e-35
YDL079c [G] KOG0658 Glycogen synthase kinase-3 144 2e-34
SPAC23H4.17c [K] KOG0666 Cyclin C-dependent kinase CDK8 144 2e-34
SPAC3C7.06c [T] KOG0661 MAPK related serine/threonine protein ki... 143 3e-34
ECU11g1290 [R] KOG0663 Protein kinase PITSLRE and related kinases 143 3e-34
At2g23080 [TDK] KOG0668 Casein kinase II alpha subunit 143 4e-34
At1g74330 [D] KOG0600 Cdc2-related protein kinase 142 6e-34
ECU02g1450 [DKL] KOG0659 Cdk activating kinase (CAK)/RNA polymer... 142 1e-33
CE26988 [DKL] KOG0659 Cdk activating kinase (CAK)/RNA polymerase... 142 1e-33
ECU11g0960 [D] KOG0600 Cdc2-related protein kinase 141 1e-33
At2g23070 [TDK] KOG0668 Casein kinase II alpha subunit 141 1e-33
At5g67380 [TDK] KOG0668 Casein kinase II alpha subunit 139 5e-33
7289745 [TDK] KOG0668 Casein kinase II alpha subunit 139 5e-33
CE17321 [TDK] KOG0668 Casein kinase II alpha subunit 138 1e-32
Hs4503429 [R] KOG0667 Dual-specificity tyrosine-phosphorylation ... 137 2e-32
SPAC23C11.11 [TDK] KOG0668 Casein kinase II alpha subunit 136 4e-32
ECU08g0230 [R] KOG0594 Protein kinase PCTAIRE and related kinases 136 4e-32
At1g18670 [D] KOG0600 Cdc2-related protein kinase 136 4e-32
7298142 [R] KOG0667 Dual-specificity tyrosine-phosphorylation re... 136 5e-32
Hs5922004 [R] KOG0667 Dual-specificity tyrosine-phosphorylation ... 134 2e-31
Hs4503427 [R] KOG0667 Dual-specificity tyrosine-phosphorylation ... 134 2e-31
Hs7106269 [DKL] KOG0659 Cdk activating kinase (CAK)/RNA polymera... 134 3e-31
ECU08g1790 [D] KOG0600 Cdc2-related protein kinase 133 4e-31
CE18608 [R] KOG0594 Protein kinase PCTAIRE and related kinases 133 4e-31
CE28918 [R] KOG0594 Protein kinase PCTAIRE and related kinases 133 5e-31
7294866 [K] KOG0666 Cyclin C-dependent kinase CDK8 133 5e-31
SPBC8D2.19 [T] KOG0661 MAPK related serine/threonine protein kinase 132 8e-31
CE08727 [G] KOG0658 Glycogen synthase kinase-3 132 1e-30
YOL128c [G] KOG0658 Glycogen synthase kinase-3 130 4e-30
Hs4502745 [K] KOG0666 Cyclin C-dependent kinase CDK8 129 9e-30
Hs17452757 [UT] KOG0662 Cyclin-dependent kinase CDK5 129 9e-30
Hs20551615 [K] KOG0666 Cyclin C-dependent kinase CDK8 127 3e-29
CE09532 [G] KOG0658 Glycogen synthase kinase-3 125 7e-29
YNL307c [G] KOG0658 Glycogen synthase kinase-3 125 1e-28
CE23751 [R] KOG0667 Dual-specificity tyrosine-phosphorylation re... 125 1e-28
CE19878 [R] KOG0667 Dual-specificity tyrosine-phosphorylation re... 125 1e-28
CE05897 [R] KOG0667 Dual-specificity tyrosine-phosphorylation re... 125 1e-28
At5g35980 [R] KOG0667 Dual-specificity tyrosine-phosphorylation ... 124 2e-28
Hs5921999 [R] KOG0667 Dual-specificity tyrosine-phosphorylation ... 124 3e-28
Hs20550209 [R] KOG0667 Dual-specificity tyrosine-phosphorylation... 123 4e-28
YJL141c [R] KOG0667 Dual-specificity tyrosine-phosphorylation re... 123 5e-28
Hs13430860 [R] KOG0667 Dual-specificity tyrosine-phosphorylation... 122 6e-28
CE19302_1 [G] KOG0658 Glycogen synthase kinase-3 122 8e-28
Hs5922001 [R] KOG0667 Dual-specificity tyrosine-phosphorylation ... 121 1e-27
CE17815 [K] KOG0666 Cyclin C-dependent kinase CDK8 121 1e-27
Hs18552621 [R] KOG0597 Serine-threonine protein kinase FUSED 120 2e-27
CE05866 [G] KOG0658 Glycogen synthase kinase-3 120 2e-27
ECU05g1510 [TDK] KOG0668 Casein kinase II alpha subunit 120 3e-27
YPL042c [K] KOG0666 Cyclin C-dependent kinase CDK8 120 4e-27
YOR061w [TDK] KOG0668 Casein kinase II alpha subunit 120 4e-27
YJL106w [T] KOG0661 MAPK related serine/threonine protein kinase 120 4e-27
YDR477w [T] KOG0583 Serine/threonine protein kinase 119 9e-27
Hs16936530 [R] KOG0594 Protein kinase PCTAIRE and related kinases 119 9e-27
CE23826 [D] KOG0669 Cyclin T-dependent kinase CDK9 118 1e-26
Hs22045050 [T] KOG0671 LAMMER dual specificity kinases 118 2e-26
CE18824 [D] KOG0669 Cyclin T-dependent kinase CDK9 118 2e-26
SPBC1604.14c [T] KOG0578 p21-activated serine/threonine protein ... 117 2e-26
SPAC2F7.03c [R] KOG0667 Dual-specificity tyrosine-phosphorylatio... 117 2e-26
Hs4758008 [T] KOG0671 LAMMER dual specificity kinases 117 2e-26
CE19219 [T] KOG0665 Jun-N-terminal kinase (JNK) 117 3e-26
SPCC777.14 [A] KOG0670 U4/U6-associated splicing factor PRP4 117 3e-26
7298004 [G] KOG0658 Glycogen synthase kinase-3 117 3e-26
SPAC1E11.03 [R] KOG0667 Dual-specificity tyrosine-phosphorylatio... 116 4e-26
ECU07g1270 [G] KOG0658 Glycogen synthase kinase-3 116 4e-26
At2g40120 [R] KOG0667 Dual-specificity tyrosine-phosphorylation ... 116 6e-26
Hs21389587 [R] KOG0667 Dual-specificity tyrosine-phosphorylation... 115 1e-25
CE20405 [G] KOG0658 Glycogen synthase kinase-3 115 1e-25
CE23605 [T] KOG0665 Jun-N-terminal kinase (JNK) 114 2e-25
Hs10190706 [T] KOG0671 LAMMER dual specificity kinases 114 3e-25
At1g50230 [R] KOG0597 Serine-threonine protein kinase FUSED 114 3e-25
7304358 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-... 113 4e-25
Hs4759050 [T] KOG0603 Ribosomal protein S6 kinase 113 5e-25
Hs6005850 [D] KOG0615 Serine/threonine protein kinase Chk2 and r... 112 6e-25
Hs20127418 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase ... 112 8e-25
At3g01090 [T] KOG0583 Serine/threonine protein kinase 111 1e-24
SPCC18B5.11c [D] KOG0615 Serine/threonine protein kinase Chk2 an... 111 2e-24
Hs20149547 [T] KOG0603 Ribosomal protein S6 kinase 110 2e-24
At1g73460 [R] KOG0667 Dual-specificity tyrosine-phosphorylation ... 110 2e-24
7291976 [R] KOG0667 Dual-specificity tyrosine-phosphorylation re... 110 2e-24
Hs14141724 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase ... 110 3e-24
Hs18581346 [T] KOG0660 Mitogen-activated protein kinase 110 4e-24
CE04430 [R] KOG0667 Dual-specificity tyrosine-phosphorylation re... 110 4e-24
At3g17750 [R] KOG0667 Dual-specificity tyrosine-phosphorylation ... 110 4e-24
Hs7706286 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase E... 109 5e-24
Hs19923570 [T] KOG0603 Ribosomal protein S6 kinase 109 5e-24
At3g29160 [T] KOG0583 Serine/threonine protein kinase 109 5e-24
Hs4758222 [R] KOG0667 Dual-specificity tyrosine-phosphorylation ... 109 7e-24
Hs11386209 [R] KOG0667 Dual-specificity tyrosine-phosphorylation... 108 9e-24
Hs17999535 [A] KOG0670 U4/U6-associated splicing factor PRP4 108 2e-23
7298926 [T] KOG0578 p21-activated serine/threonine protein kinase 108 2e-23
Hs7662210 [OUT] KOG0595 Serine/threonine-protein kinase involved... 107 2e-23
At5g39440 [T] KOG0583 Serine/threonine protein kinase 107 2e-23
Hs5453882 [G] KOG0599 Phosphorylase kinase gamma subunit 107 3e-23
Hs18765758 [R] KOG0667 Dual-specificity tyrosine-phosphorylation... 107 3e-23
Hs18765756 [R] KOG0667 Dual-specificity tyrosine-phosphorylation... 107 3e-23
Hs18765754 [R] KOG0667 Dual-specificity tyrosine-phosphorylation... 107 3e-23
Hs18765752 [R] KOG0667 Dual-specificity tyrosine-phosphorylation... 107 3e-23
Hs18765750 [R] KOG0667 Dual-specificity tyrosine-phosphorylation... 107 3e-23
Hs14771959 [T] KOG0578 p21-activated serine/threonine protein ki... 107 3e-23
YIL035c [TDK] KOG0668 Casein kinase II alpha subunit 107 4e-23
CE05686 [A] KOG0670 U4/U6-associated splicing factor PRP4 107 4e-23
CE05377 [G] KOG0658 Glycogen synthase kinase-3 107 4e-23
CE28061 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-... 106 6e-23
CE28060 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-... 106 6e-23
CE28059 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-... 106 6e-23
CE28058 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-... 106 6e-23
CE28057 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-... 106 6e-23
CE28056 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-... 106 6e-23
CE28055 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-... 106 6e-23
CE28054 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-... 106 6e-23
CE28053 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-... 106 6e-23
CE28051 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-... 106 6e-23
At1g08650 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 105 1e-22
Hs7657526 [T] KOG0603 Ribosomal protein S6 kinase 105 1e-22
CE19749 [T] KOG0665 Jun-N-terminal kinase (JNK) 104 2e-22
Hs4505785 [G] KOG0599 Phosphorylase kinase gamma subunit 104 2e-22
At5g23580 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 103 3e-22
7293496 [R] KOG0597 Serine-threonine protein kinase FUSED 103 3e-22
SPCC74.03c [T] KOG0583 Serine/threonine protein kinase 102 7e-22
Hs16306492 [R] KOG0594 Protein kinase PCTAIRE and related kinases 102 7e-22
CE06352 [R] KOG0667 Dual-specificity tyrosine-phosphorylation re... 102 7e-22
CE04173 [R] KOG0667 Dual-specificity tyrosine-phosphorylation re... 102 7e-22
SPAC1D4.11c [T] KOG0671 LAMMER dual specificity kinases 102 9e-22
At1g73450 [R] KOG0667 Dual-specificity tyrosine-phosphorylation ... 102 9e-22
YGL179c [T] KOG0585 Ca2+/calmodulin-dependent protein kinase kin... 102 1e-21
HsM4758524 [T] KOG0587 Traf2- and Nck-interacting kinase and rel... 102 1e-21
Hs4505601 [T] KOG0578 p21-activated serine/threonine protein kinase 102 1e-21
Hs22035606 [T] KOG0587 Traf2- and Nck-interacting kinase and rel... 102 1e-21
Hs22035604 [T] KOG0587 Traf2- and Nck-interacting kinase and rel... 102 1e-21
Hs22035602 [T] KOG0587 Traf2- and Nck-interacting kinase and rel... 102 1e-21
At2g41140 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 102 1e-21
Hs9910476 [T] KOG0578 p21-activated serine/threonine protein kinase 101 1e-21
At1g54510 [R] KOG0589 Serine/threonine protein kinase 101 1e-21
Hs4502885_2 [T] KOG0671 LAMMER dual specificity kinases 101 1e-21
7292249 [T] KOG0587 Traf2- and Nck-interacting kinase and relate... 101 2e-21
CE18967 [T] KOG4236 Serine/threonine protein kinase PKC mu/PKD a... 100 3e-21
CE24516 [OUT] KOG0595 Serine/threonine-protein kinase involved i... 100 3e-21
At3g50530 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 100 3e-21
YOL113w [T] KOG0578 p21-activated serine/threonine protein kinase 100 4e-21
YHL007c [T] KOG0578 p21-activated serine/threonine protein kinase 100 4e-21
YDL101c [D] KOG0615 Serine/threonine protein kinase Chk2 and rel... 100 4e-21
Hs7382496 [T] KOG0578 p21-activated serine/threonine protein kinase 100 4e-21
Hs4505599 [T] KOG0578 p21-activated serine/threonine protein kinase 100 4e-21
Hs20479818 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase ... 100 4e-21
SPAC23C11.16 [D] KOG0575 Polo-like serine/threonine protein kinase 100 6e-21
CE28251 [D] KOG0615 Serine/threonine protein kinase Chk2 and rel... 100 6e-21
At1g01140 [T] KOG0583 Serine/threonine protein kinase 100 6e-21
7290150 [T] KOG0583 Serine/threonine protein kinase 100 6e-21
Hs7657214 [T] KOG0583 Serine/threonine protein kinase 99 7e-21
Hs4507831 [OUT] KOG0595 Serine/threonine-protein kinase involved... 99 7e-21
At3g20860 [R] KOG0589 Serine/threonine protein kinase 99 7e-21
7300149 [T] KOG0578 p21-activated serine/threonine protein kinase 99 7e-21
YDR466w [T] KOG0592 3-phosphoinositide-dependent protein kinase ... 99 1e-20
SPCC576.15c [T] KOG0592 3-phosphoinositide-dependent protein kin... 99 1e-20
Hs5031689 [T] KOG4236 Serine/threonine protein kinase PKC mu/PKD... 99 1e-20
CE04172 [R] KOG0667 Dual-specificity tyrosine-phosphorylation re... 99 1e-20
Hs4506075 [T] KOG4236 Serine/threonine protein kinase PKC mu/PKD... 99 1e-20
Hs9994197 [T] KOG0607 MAP kinase-interacting kinase and related ... 98 2e-20
Hs5031975 [T] KOG0578 p21-activated serine/threonine protein kinase 98 2e-20
At3g56760 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 98 2e-20
SPCC320.12c [D] KOG0580 Serine/threonine protein kinase 98 2e-20
SPBC4C3.11 [T] KOG0592 3-phosphoinositide-dependent protein kina... 98 2e-20
Hs5454094 [T] KOG0574 STE20-like serine/threonine kinase MST 98 2e-20
CE01612 [G] KOG0658 Glycogen synthase kinase-3 98 2e-20
At3g19100 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 98 2e-20
At2g35890 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 98 2e-20
7298652 [D] KOG0615 Serine/threonine protein kinase Chk2 and rel... 98 2e-20
7291932 [A] KOG0670 U4/U6-associated splicing factor PRP4 98 2e-20
HsM4506099 [T] KOG0984 Mitogen-activated protein kinase (MAPK) k... 97 3e-20
Hs7657335 [T] KOG0587 Traf2- and Nck-interacting kinase and rela... 97 3e-20
Hs5454096 [T] KOG0574 STE20-like serine/threonine kinase MST 97 3e-20
Hs21618351 [T] KOG0984 Mitogen-activated protein kinase (MAPK) k... 97 3e-20
Hs21618349 [T] KOG0984 Mitogen-activated protein kinase (MAPK) k... 97 3e-20
Hs21618347 [T] KOG0984 Mitogen-activated protein kinase (MAPK) k... 97 3e-20
CE27670 [T] KOG0578 p21-activated serine/threonine protein kinase 97 3e-20
At3g49370 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 97 3e-20
Hs5453964 [T] KOG0583 Serine/threonine protein kinase 97 4e-20
At4g09570 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 97 4e-20
At4g04720 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 97 4e-20
At3g04530 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 97 4e-20
YHR102w [T] KOG0201 Serine/threonine protein kinase 97 5e-20
HsM4505191 [T] KOG0607 MAP kinase-interacting kinase and related... 97 5e-20
Hs6031180 [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and... 97 5e-20
Hs5803088 [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and... 97 5e-20
CE27297 [D] KOG0615 Serine/threonine protein kinase Chk2 and rel... 97 5e-20
At4g18700 [T] KOG0583 Serine/threonine protein kinase 97 5e-20
YAR019c [T] KOG0198 MEKK and related serine/threonine protein ki... 96 6e-20
Hs4502803 [D] KOG0590 Checkpoint kinase and related serine/threo... 96 6e-20
Hs16178962 [T] KOG0574 STE20-like serine/threonine kinase MST 96 6e-20
At5g62310 [TR] KOG0606 Microtubule-associated serine/threonine k... 96 6e-20
At1g35670 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 96 6e-20
YCL024w [T] KOG0583 Serine/threonine protein kinase 96 8e-20
Hs19923468 [T] KOG4236 Serine/threonine protein kinase PKC mu/PK... 96 8e-20
CE17284 [T] KOG0583 Serine/threonine protein kinase 96 8e-20
At2g37840 [OUT] KOG0595 Serine/threonine-protein kinase involved... 96 8e-20
At2g31500 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 96 8e-20
At1g13350 [A] KOG0670 U4/U6-associated splicing factor PRP4 96 8e-20
7294537 [OUT] KOG0595 Serine/threonine-protein kinase involved i... 96 8e-20
YDR507c [D] KOG0588 Serine/threonine protein kinase 96 1e-19
CE20167 [T] KOG4236 Serine/threonine protein kinase PKC mu/PKD a... 96 1e-19
At5g24430 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 96 1e-19
CE18169 [T] KOG0603 Ribosomal protein S6 kinase 95 1e-19
CE13014 [T] KOG0603 Ribosomal protein S6 kinase 95 1e-19
YMR001c [D] KOG0575 Polo-like serine/threonine protein kinase 95 2e-19
ECU02g0550 [D] KOG0575 Polo-like serine/threonine protein kinase 95 2e-19
CE07458 [T] KOG0583 Serine/threonine protein kinase 95 2e-19
At3g61960 [OUT] KOG0595 Serine/threonine-protein kinase involved... 95 2e-19
At2g17890 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 95 2e-19
ECU07g0360 [D] KOG0580 Serine/threonine protein kinase 94 2e-19
At5g45810 [T] KOG0583 Serine/threonine protein kinase 94 2e-19
CE28273 [T] KOG0587 Traf2- and Nck-interacting kinase and relate... 94 3e-19
CE25673 [T] KOG0587 Traf2- and Nck-interacting kinase and relate... 94 3e-19
CE25672 [T] KOG0587 Traf2- and Nck-interacting kinase and relate... 94 3e-19
At5g19450 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 94 3e-19
At5g10930 [T] KOG0583 Serine/threonine protein kinase 94 3e-19
At4g24740 [T] KOG0671 LAMMER dual specificity kinases 94 3e-19
Hs20547806 [R] KOG0589 Serine/threonine protein kinase 94 4e-19
At3g15220 [T] KOG0201 Serine/threonine protein kinase 94 4e-19
YNL298w [T] KOG0578 p21-activated serine/threonine protein kinase 93 5e-19
SPAC1F5.09c [T] KOG0578 p21-activated serine/threonine protein k... 93 5e-19
Hs14776113 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase ... 93 5e-19
ECU11g0180 [R] KOG0667 Dual-specificity tyrosine-phosphorylation... 93 5e-19
At5g25110 [T] KOG0583 Serine/threonine protein kinase 93 5e-19
At4g24400 [T] KOG0583 Serine/threonine protein kinase 93 5e-19
At2g30360 [T] KOG0583 Serine/threonine protein kinase 93 5e-19
At1g49580 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 93 5e-19
7292679 [G] KOG0599 Phosphorylase kinase gamma subunit 93 5e-19
Hs4502883_2 [T] KOG0671 LAMMER dual specificity kinases 93 5e-19
CE28643 [T] KOG0583 Serine/threonine protein kinase 93 7e-19
At3g25840 [A] KOG0670 U4/U6-associated splicing factor PRP4 93 7e-19
Hs4507277_1 [R] KOG0589 Serine/threonine protein kinase 93 7e-19
SPAC9G1.02 [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 an... 92 9e-19
Hs4759052 [T] KOG0603 Ribosomal protein S6 kinase 92 9e-19
CE05780 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-... 92 9e-19
At5g66210 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 92 9e-19
At2g46700 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 92 9e-19
Hs8393810_1 [T] KOG0587 Traf2- and Nck-interacting kinase and re... 92 9e-19
Hs20544910_1 [T] KOG0587 Traf2- and Nck-interacting kinase and r... 92 9e-19
Hs5453966 [T] KOG0583 Serine/threonine protein kinase 92 1e-18
7300559 [T] KOG4279 Serine/threonine protein kinase 92 1e-18
7299160 [OUT] KOG0595 Serine/threonine-protein kinase involved i... 92 1e-18
7297080 [T] KOG0583 Serine/threonine protein kinase 92 1e-18
Hs7662170 [R] KOG0611 Predicted serine/threonine protein kinase 92 2e-18
CE21615 [T] KOG0578 p21-activated serine/threonine protein kinase 92 2e-18
CE09360 [Z] KOG0613 Projectin/twitchin and related proteins 92 2e-18
At5g07070 [T] KOG0583 Serine/threonine protein kinase 92 2e-18
At1g76040 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 92 2e-18
7300435 [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and r... 92 2e-18
YJL095w [T] KOG0198 MEKK and related serine/threonine protein ki... 91 2e-18
SPAC1B9.02c [RT] KOG0598 Ribosomal protein S6 kinase and related... 91 2e-18
Hs14728804 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase ... 91 2e-18
At2g41860 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 91 2e-18
At2g26980 [T] KOG0583 Serine/threonine protein kinase 91 2e-18
7299438 [R] KOG0586 Serine/threonine protein kinase 91 2e-18
SPCC1259.13 [D] KOG0590 Checkpoint kinase and related serine/thr... 91 3e-18
SPBC17F3.02 [T] KOG0201 Serine/threonine protein kinase 91 3e-18
Hs14589900 [T] KOG0984 Mitogen-activated protein kinase (MAPK) k... 91 3e-18
Hs4502553 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 91 3e-18
Hs14196445 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase ... 91 3e-18
At5g57630 [T] KOG0583 Serine/threonine protein kinase 91 3e-18
At5g01810 [T] KOG0583 Serine/threonine protein kinase 91 3e-18
At1g77720 [D] KOG0596 Dual specificity; serine/threonine and tyr... 91 3e-18
SPBC409.07c [T] KOG0581 Mitogen-activated protein kinase kinase ... 90 4e-18
SPAC23H4.02 [T] KOG0583 Serine/threonine protein kinase 90 4e-18
HsM7657627 [D] KOG0575 Polo-like serine/threonine protein kinase 90 4e-18
CE27965 [T] KOG0574 STE20-like serine/threonine kinase MST 90 4e-18
CE27726 [T] KOG0574 STE20-like serine/threonine kinase MST 90 4e-18
CE27082 [T] KOG0574 STE20-like serine/threonine kinase MST 90 4e-18
CE24993 [D] KOG0669 Cyclin T-dependent kinase CDK9 90 4e-18
CE07064 [T] KOG0574 STE20-like serine/threonine kinase MST 90 4e-18
CE05507 [T] KOG0603 Ribosomal protein S6 kinase 90 4e-18
At3g53640 [A] KOG0670 U4/U6-associated splicing factor PRP4 90 4e-18
Hs14589902 [T] KOG0984 Mitogen-activated protein kinase (MAPK) k... 90 6e-18
At5g28290 [R] KOG0589 Serine/threonine protein kinase 90 6e-18
7301719 [T] KOG0671 LAMMER dual specificity kinases 90 6e-18
YDL159w [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K) 89 8e-18
CE07905 [T] KOG0579 Ste20-like serine/threonine protein kinase 89 8e-18
At3g04810 [R] KOG0589 Serine/threonine protein kinase 89 8e-18
Hs5730055 [D] KOG0575 Polo-like serine/threonine protein kinase 89 1e-17
Hs4758016 [D] KOG0575 Polo-like serine/threonine protein kinase 89 1e-17
Hs14770402 [R] KOG0586 Serine/threonine protein kinase 89 1e-17
At5g58380 [T] KOG0583 Serine/threonine protein kinase 89 1e-17
At5g35410 [T] KOG0583 Serine/threonine protein kinase 89 1e-17
At4g29810 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 89 1e-17
Hs20428779_1 [T] KOG0587 Traf2- and Nck-interacting kinase and r... 89 1e-17
YOL100w [T] KOG0592 3-phosphoinositide-dependent protein kinase ... 89 1e-17
Hs4826878 [T] KOG0582 Ste20-like serine/threonine protein kinase 89 1e-17
Hs21361433 [D] KOG0575 Polo-like serine/threonine protein kinase 89 1e-17
At1g30270 [T] KOG0583 Serine/threonine protein kinase 89 1e-17
>YGR040w [T] KOG0660 Mitogen-activated protein kinase
Length = 368
Score = 582 bits (1499), Expect = e-166
Identities = 276/367 (75%), Positives = 317/367 (86%), Gaps = 6/367 (1%)
Query: 1 MPRTITYDIPSHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTLREL 60
M RTIT+DIPS Y+LVDL+GEGAYGTVCSAIHKP+ KVAIKKIQPFS+ +FVTRT+RE+
Sbjct: 1 MARTITFDIPSQYKLVDLIGEGAYGTVCSAIHKPSGIKVAIKKIQPFSKKLFVTRTIREI 60
Query: 61 KLLKFFHSHENIISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQN-----LSEDHI 115
KLL++FH HENIIS+LD VRP S K AVYLV+ELMETDLQK+IN QN LS+DH+
Sbjct: 61 KLLRYFHEHENIISILDKVRPVSIDKLNAVYLVEELMETDLQKVINNQNSGFSTLSDDHV 120
Query: 116 QYFVYQILRALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVG 175
QYF YQILRALKS+HSAQVIHRD+KPSNLLLNSNCDLKVCDFGLARCLASS SRE +VG
Sbjct: 121 QYFTYQILRALKSIHSAQVIHRDIKPSNLLLNSNCDLKVCDFGLARCLASSSDSRETLVG 180
Query: 176 FMTEYVATRWYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILE 235
FMTEYVATRWYRAPEIML+FQEYTTAMDIWSCGCILAEM+ GKPLFPG+DYHHQLW+ILE
Sbjct: 181 FMTEYVATRWYRAPEIMLTFQEYTTAMDIWSCGCILAEMVSGKPLFPGRDYHHQLWLILE 240
Query: 236 VLGSPTLEDFEQIKSKRAKEYISQLPMKKGIPWANVLNK-EVNPLAIDLLSKMLTFNPDK 294
VLG+P+ EDF QIKSKRAKEYI+ LPM+ +PW V +K ++NP IDLL KML FNPDK
Sbjct: 241 VLGTPSFEDFNQIKSKRAKEYIANLPMRPPLPWETVWSKTDLNPDMIDLLDKMLQFNPDK 300
Query: 295 RISAVEALEHPYLATYHDPDDEPDYPQLNLEDNFWKIDNEARDKNEEDDIPLELLKKMLY 354
RISA EAL HPYLA YHDP DEP+YP LNL+D FWK+DN+ EE+++P+E+LK MLY
Sbjct: 301 RISAAEALRHPYLAMYHDPSDEPEYPPLNLDDEFWKLDNKIMRPEEEEEVPIEMLKDMLY 360
Query: 355 GEVMKPL 361
E+MK +
Sbjct: 361 DELMKTM 367
>SPAC31G5.09c [T] KOG0660 Mitogen-activated protein kinase
Length = 372
Score = 409 bits (1050), Expect = e-114
Identities = 201/355 (56%), Positives = 266/355 (74%), Gaps = 18/355 (5%)
Query: 5 ITYDIPSHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTLRELKLLK 64
+ +++P Y++++L+G+GAYG VC+A+HKP+ KVA+KKI PF+ +F RTLRE+KLL+
Sbjct: 31 LNFELPEEYEMINLIGQGAYGVVCAALHKPSGLKVAVKKIHPFNHPVFCLRTLREIKLLR 90
Query: 65 FFHSHENIISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQNLSEDHIQYFVYQILR 124
F HENIIS+LDI+ P S+ + E VY+VQELMETDL ++I Q LS+DH QYF YQILR
Sbjct: 91 HFR-HENIISILDILPPPSYQELEDVYIVQELMETDLYRVIRSQPLSDDHCQYFTYQILR 149
Query: 125 ALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATR 184
ALK++HSA V+HRDLKPSNLLLN+NCDLKV DFGLAR S ++ GFMTEYVATR
Sbjct: 150 ALKAMHSAGVVHRDLKPSNLLLNANCDLKVADFGLAR----STTAQGGNPGFMTEYVATR 205
Query: 185 WYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLED 244
WYRAPEIMLSF+EY+ A+D+WS GCILAEM+ +PLFPGKDYH Q+ +IL +LG+PT++D
Sbjct: 206 WYRAPEIMLSFREYSKAIDLWSTGCILAEMLSARPLFPGKDYHSQITLILNILGTPTMDD 265
Query: 245 FEQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEH 304
F +IKS RA++YI LP + + L + +P AIDLL K+LTFNPDKRI+A EAL+H
Sbjct: 266 FSRIKSARARKYIKSLPFTPKVSF-KALFPQASPDAIDLLEKLLTFNPDKRITAEEALKH 324
Query: 305 PYLATYHDPDDEPDYPQL--NLEDNFWKIDNEARDKNEEDDIPLELLKKMLYGEV 357
PY+A YHD DEP + NL D + ++D+ + +LK +++ EV
Sbjct: 325 PYVAAYHDASDEPTASPMPPNLVDLYC----------NKEDLEIPVLKALIFREV 369
>YBL016w [T] KOG0660 Mitogen-activated protein kinase
Length = 353
Score = 394 bits (1011), Expect = e-109
Identities = 198/361 (54%), Positives = 257/361 (70%), Gaps = 14/361 (3%)
Query: 1 MPRTITYDIPSHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTLREL 60
MP+ I Y+I S +QL L+GEGAYG VCSA HKPT VAIKKI+PF + +F RTLRE+
Sbjct: 1 MPKRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREI 60
Query: 61 KLLKFFHSHENIISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQNLSEDHIQYFVY 120
K+LK F HENII++ +I RP S+ F VY++QELM+TDL ++I+ Q LS+DHIQYF+Y
Sbjct: 61 KILKHF-KHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIY 119
Query: 121 QILRALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVG---FM 177
Q LRA+K LH + VIHRDLKPSNLL+NSNCDLKVCDFGLAR + S G M
Sbjct: 120 QTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGM 179
Query: 178 TEYVATRWYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVL 237
TEYVATRWYRAPE+ML+ +Y+ AMD+WSCGCILAE+ + +P+FPG+DY HQL +I ++
Sbjct: 180 TEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGII 239
Query: 238 GSPTLE-DFEQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRI 296
G+P + D I+S RA+EYI LPM P + + VNP IDLL +ML F+P KRI
Sbjct: 240 GTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPR-VNPKGIDLLQRMLVFDPAKRI 298
Query: 297 SAVEALEHPYLATYHDPDDEPDYPQLNLEDNFWKIDNEARDKNEEDDIPLELLKKMLYGE 356
+A EALEHPYL TYHDP+DEP+ + +F++ D+ +D LKK+++ E
Sbjct: 299 TAKEALEHPYLQTYHDPNDEPEGEP--IPPSFFEFDHYKEALTTKD------LKKLIWNE 350
Query: 357 V 357
+
Sbjct: 351 I 351
>Hs20986529 [T] KOG0660 Mitogen-activated protein kinase
Length = 360
Score = 351 bits (900), Expect = 1e-96
Identities = 186/359 (51%), Positives = 238/359 (65%), Gaps = 18/359 (5%)
Query: 1 MPRTITYDIPSHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTLREL 60
M R +D+ Y + +GEGAYG VCSA +VAIKKI PF + RTLRE+
Sbjct: 13 MVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREI 72
Query: 61 KLLKFFHSHENIISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQNLSEDHIQYFVY 120
K+L F HENII + DI+R + + + VY+VQ+LMETDL K++ Q+LS DHI YF+Y
Sbjct: 73 KILLRFR-HENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLY 131
Query: 121 QILRALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEY 180
QILR LK +HSA V+HRDLKPSNLLLN+ CDLK+CDFGLAR +A D GF+TEY
Sbjct: 132 QILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLAR-VADPDHDH---TGFLTEY 187
Query: 181 VATRWYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSP 240
VATRWYRAPEIML+ + YT ++DIWS GCILAEM+ +P+FPGK Y QL IL +LGSP
Sbjct: 188 VATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLKHILGILGSP 247
Query: 241 TLEDFEQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVE 300
+ ED I + +A+ Y+ LP K +PW N L + A+DLL KMLTFNP KRI +
Sbjct: 248 SQEDLNCIINLKARNYLLSLPHKNKVPW-NRLFPNADSKALDLLDKMLTFNPHKRIEVEQ 306
Query: 301 ALEHPYLATYHDPDDEPDYPQLNLEDNFWKIDNEARDKNEEDDIPLELLKKMLYGEVMK 359
AL HPYL Y+DP DEP + + +K D E DD+P E LK++++ E +
Sbjct: 307 ALAHPYLEQYYDPSDEP------IAEAPFKFDMEL------DDLPKEKLKELIFEETAR 353
>Hs20986531 [T] KOG0660 Mitogen-activated protein kinase
Length = 360
Score = 350 bits (899), Expect = 1e-96
Identities = 186/359 (51%), Positives = 238/359 (65%), Gaps = 18/359 (5%)
Query: 1 MPRTITYDIPSHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTLREL 60
M R +D+ Y + +GEGAYG VCSA +VAIKKI PF + RTLRE+
Sbjct: 13 MVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREI 72
Query: 61 KLLKFFHSHENIISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQNLSEDHIQYFVY 120
K+L F HENII + DI+R + + + VY+VQ+LMETDL K++ Q+LS DHI YF+Y
Sbjct: 73 KILLRFR-HENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLY 131
Query: 121 QILRALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEY 180
QILR LK +HSA V+HRDLKPSNLLLN+ CDLK+CDFGLAR +A D GF+TEY
Sbjct: 132 QILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLAR-VADPDHDH---TGFLTEY 187
Query: 181 VATRWYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSP 240
VATRWYRAPEIML+ + YT ++DIWS GCILAEM+ +P+FPGK Y QL IL +LGSP
Sbjct: 188 VATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSP 247
Query: 241 TLEDFEQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVE 300
+ ED I + +A+ Y+ LP K +PW N L + A+DLL KMLTFNP KRI +
Sbjct: 248 SQEDLNCIINLKARNYLLSLPHKNKVPW-NRLFPNADSKALDLLDKMLTFNPHKRIEVEQ 306
Query: 301 ALEHPYLATYHDPDDEPDYPQLNLEDNFWKIDNEARDKNEEDDIPLELLKKMLYGEVMK 359
AL HPYL Y+DP DEP + + +K D E DD+P E LK++++ E +
Sbjct: 307 ALAHPYLEQYYDPSDEP------IAEAPFKFDMEL------DDLPKEKLKELIFEETAR 353
>Hs20562757 [T] KOG0660 Mitogen-activated protein kinase
Length = 379
Score = 340 bits (873), Expect = 1e-93
Identities = 177/353 (50%), Positives = 233/353 (65%), Gaps = 18/353 (5%)
Query: 7 YDIPSHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTLRELKLLKFF 66
+D+ Y + +GEGAYG V SA T+VAIKKI PF + RTLRE+++L F
Sbjct: 36 FDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRF 95
Query: 67 HSHENIISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQNLSEDHIQYFVYQILRAL 126
HEN+I + DI+R ++ VY+VQ+LMETDL K++ Q LS DHI YF+YQILR L
Sbjct: 96 R-HENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGL 154
Query: 127 KSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWY 186
K +HSA V+HRDLKPSNLL+N+ CDLK+CDFGLAR +D ++ GF+TEYVATRWY
Sbjct: 155 KYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARI---ADPEHDH-TGFLTEYVATRWY 210
Query: 187 RAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFE 246
RAPEIML+ + YT ++DIWS GCILAEM+ +P+FPGK Y QL IL +LGSP+ ED
Sbjct: 211 RAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLN 270
Query: 247 QIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEHPY 306
I + +A+ Y+ LP K + WA + K + A+DLL +MLTFNP+KRI+ EAL HPY
Sbjct: 271 CIINMKARNYLQSLPSKTKVAWAKLFPKS-DSKALDLLDRMLTFNPNKRITVEEALAHPY 329
Query: 307 LATYHDPDDEPDYPQLNLEDNFWKIDNEARDKNEEDDIPLELLKKMLYGEVMK 359
L Y+DP DEP + E DD+P E LK++++ E +
Sbjct: 330 LEQYYDPTDEP------------VAEEPFTFAMELDDLPKERLKELIFQETAR 370
>CE24971 [T] KOG0660 Mitogen-activated protein kinase
Length = 444
Score = 337 bits (865), Expect = 1e-92
Identities = 178/351 (50%), Positives = 231/351 (65%), Gaps = 20/351 (5%)
Query: 7 YDIPSHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTLRELKLLKFF 66
+++ Y + +GEGAYG V SA+ T +VAIKKI PF F RTLRE+K+L F
Sbjct: 90 FEVAPRYVNLSYIGEGAYGMVASALDTITRDRVAIKKISPFEHQTFCQRTLREIKILNRF 149
Query: 67 HSHENIISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQNLSEDHIQYFVYQILRAL 126
HENII++ +I+R + + +Y+VQ LMETDL K++ Q LS DH+ YF+YQILR L
Sbjct: 150 -KHENIINIQEIIRSETVDSLKDIYIVQCLMETDLYKLLKTQKLSNDHVCYFLYQILRGL 208
Query: 127 KSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWY 186
K +HSA V+HRDLKPSNLLLN+ CDLK+CDFGLAR + + GF+TEYVATRWY
Sbjct: 209 KYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARV----TDPQTDHTGFLTEYVATRWY 264
Query: 187 RAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFE 246
RAPEIML+ + YT ++D+WS GCILAEM+ +PLFPGK Y QL +IL V+GSP+ D +
Sbjct: 265 RAPEIMLNSKGYTKSIDVWSVGCILAEMLSNRPLFPGKHYLDQLNLILAVVGSPSNADLQ 324
Query: 247 QIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEHPY 306
I + +A+ Y+ LP K PWA L +P A+DLL KMLTFNP RI +AL HPY
Sbjct: 325 CIINDKARSYLISLPHKPKQPWAR-LYPGADPRALDLLDKMLTFNPHNRIDIEQALAHPY 383
Query: 307 LATYHDPDDEPDYPQ-LNLEDNFWKIDNEARDKNEEDDIPLELLKKMLYGE 356
L Y+DP DEP + LE F DD+P E LK++++ E
Sbjct: 384 LEQYYDPGDEPVCEEPFTLEMEF-------------DDLPKEKLKELIWEE 421
>CE01583 [T] KOG0660 Mitogen-activated protein kinase
Length = 376
Score = 337 bits (865), Expect = 1e-92
Identities = 178/351 (50%), Positives = 231/351 (65%), Gaps = 20/351 (5%)
Query: 7 YDIPSHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTLRELKLLKFF 66
+++ Y + +GEGAYG V SA+ T +VAIKKI PF F RTLRE+K+L F
Sbjct: 22 FEVAPRYVNLSYIGEGAYGMVASALDTITRDRVAIKKISPFEHQTFCQRTLREIKILNRF 81
Query: 67 HSHENIISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQNLSEDHIQYFVYQILRAL 126
HENII++ +I+R + + +Y+VQ LMETDL K++ Q LS DH+ YF+YQILR L
Sbjct: 82 -KHENIINIQEIIRSETVDSLKDIYIVQCLMETDLYKLLKTQKLSNDHVCYFLYQILRGL 140
Query: 127 KSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWY 186
K +HSA V+HRDLKPSNLLLN+ CDLK+CDFGLAR + + GF+TEYVATRWY
Sbjct: 141 KYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARV----TDPQTDHTGFLTEYVATRWY 196
Query: 187 RAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFE 246
RAPEIML+ + YT ++D+WS GCILAEM+ +PLFPGK Y QL +IL V+GSP+ D +
Sbjct: 197 RAPEIMLNSKGYTKSIDVWSVGCILAEMLSNRPLFPGKHYLDQLNLILAVVGSPSNADLQ 256
Query: 247 QIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEHPY 306
I + +A+ Y+ LP K PWA L +P A+DLL KMLTFNP RI +AL HPY
Sbjct: 257 CIINDKARSYLISLPHKPKQPWAR-LYPGADPRALDLLDKMLTFNPHNRIDIEQALAHPY 315
Query: 307 LATYHDPDDEPDYPQ-LNLEDNFWKIDNEARDKNEEDDIPLELLKKMLYGE 356
L Y+DP DEP + LE F DD+P E LK++++ E
Sbjct: 316 LEQYYDPGDEPVCEEPFTLEMEF-------------DDLPKEKLKELIWEE 353
>Hs20986501 [T] KOG0660 Mitogen-activated protein kinase
Length = 816
Score = 325 bits (832), Expect = 8e-89
Identities = 166/317 (52%), Positives = 225/317 (70%), Gaps = 8/317 (2%)
Query: 5 ITYDIPSHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKI-QPFSRSMFVTRTLRELKLL 63
+T+D+ Y++++ +G GAYG V SA + T +VAIKKI F RTLRELK+L
Sbjct: 47 VTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKIL 106
Query: 64 KFFHSHENIISVLDIVRPT-SWHKFEAVYLVQELMETDLQKIINQ-QNLSEDHIQYFVYQ 121
K F H+NII++ DI+RPT + +F++VY+V +LME+DL +II+ Q L+ +H++YF+YQ
Sbjct: 107 KHF-KHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQ 165
Query: 122 ILRALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYV 181
+LR LK +HSAQVIHRDLKPSNLL+N NC+LK+ DFG+AR L +S + FMTEYV
Sbjct: 166 LLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQY---FMTEYV 222
Query: 182 ATRWYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPT 241
ATRWYRAPE+MLS EYT A+D+WS GCI EM+ + LFPGK+Y HQL +I+ VLG+P+
Sbjct: 223 ATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPS 282
Query: 242 LEDFEQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEA 301
+ + ++R + YI LP ++ +PW V + A+ LL +ML F P RISA A
Sbjct: 283 PAVIQAVGAERVRAYIQSLPPRQPVPWETVY-PGADRQALSLLGRMLRFEPSARISAAAA 341
Query: 302 LEHPYLATYHDPDDEPD 318
L HP+LA YHDPDDEPD
Sbjct: 342 LRHPFLAKYHDPDDEPD 358
>Hs20986497 [T] KOG0660 Mitogen-activated protein kinase
Length = 816
Score = 325 bits (832), Expect = 8e-89
Identities = 166/317 (52%), Positives = 225/317 (70%), Gaps = 8/317 (2%)
Query: 5 ITYDIPSHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKI-QPFSRSMFVTRTLRELKLL 63
+T+D+ Y++++ +G GAYG V SA + T +VAIKKI F RTLRELK+L
Sbjct: 47 VTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKIL 106
Query: 64 KFFHSHENIISVLDIVRPT-SWHKFEAVYLVQELMETDLQKIINQ-QNLSEDHIQYFVYQ 121
K F H+NII++ DI+RPT + +F++VY+V +LME+DL +II+ Q L+ +H++YF+YQ
Sbjct: 107 KHF-KHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQ 165
Query: 122 ILRALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYV 181
+LR LK +HSAQVIHRDLKPSNLL+N NC+LK+ DFG+AR L +S + FMTEYV
Sbjct: 166 LLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQY---FMTEYV 222
Query: 182 ATRWYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPT 241
ATRWYRAPE+MLS EYT A+D+WS GCI EM+ + LFPGK+Y HQL +I+ VLG+P+
Sbjct: 223 ATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPS 282
Query: 242 LEDFEQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEA 301
+ + ++R + YI LP ++ +PW V + A+ LL +ML F P RISA A
Sbjct: 283 PAVIQAVGAERVRAYIQSLPPRQPVPWETVY-PGADRQALSLLGRMLRFEPSARISAAAA 341
Query: 302 LEHPYLATYHDPDDEPD 318
L HP+LA YHDPDDEPD
Sbjct: 342 LRHPFLAKYHDPDDEPD 358
>At3g45640 [T] KOG0660 Mitogen-activated protein kinase
Length = 370
Score = 319 bits (818), Expect = 3e-87
Identities = 166/314 (52%), Positives = 220/314 (69%), Gaps = 13/314 (4%)
Query: 7 YDIPSHYQLVDL-VGEGAYGTVCSAIHKPTNTKVAIKKI-QPFSRSMFVTRTLRELKLLK 64
++I S Y+ + +G GAYG VCS + TN VA+KKI F M RTLRE+KLL+
Sbjct: 31 FEITSKYRPPIIPIGRGAYGIVCSVLDTETNELVAMKKIANAFDNHMDAKRTLREIKLLR 90
Query: 65 FFHSHENIISVLDIVRPTSWHKFEAVYLVQELMETDLQKII-NQQNLSEDHIQYFVYQIL 123
HENII++ D+V P +F VY+ ELM+TDL +II + Q+LSE+H QYF+YQ+L
Sbjct: 91 HL-DHENIIAIRDVVPPPLRRQFSDVYISTELMDTDLHQIIRSNQSLSEEHCQYFLYQLL 149
Query: 124 RALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVAT 183
R LK +HSA +IHRDLKPSNLLLN+NCDLK+CDFGLAR + +D FMTEYV T
Sbjct: 150 RGLKYIHSANIIHRDLKPSNLLLNANCDLKICDFGLARPTSEND--------FMTEYVVT 201
Query: 184 RWYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLE 243
RWYRAPE++L+ +YT A+D+WS GCI E++ KPLFPGKD+ HQ+ ++ E+LG+PT
Sbjct: 202 RWYRAPELLLNSSDYTAAIDVWSVGCIFMELMNRKPLFPGKDHVHQMRLLTELLGTPTES 261
Query: 244 DFEQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALE 303
D ++ AK YI QLP P A + + VNP+AIDL+ +MLTF+P++RI+ +AL
Sbjct: 262 DLGFTHNEDAKRYIRQLPNFPRQPLAKLFS-HVNPMAIDLVDRMLTFDPNRRITVEQALN 320
Query: 304 HPYLATYHDPDDEP 317
H YLA HDP+DEP
Sbjct: 321 HQYLAKLHDPNDEP 334
>At2g43790 [T] KOG0660 Mitogen-activated protein kinase
Length = 395
Score = 318 bits (815), Expect = 8e-87
Identities = 172/344 (50%), Positives = 236/344 (68%), Gaps = 29/344 (8%)
Query: 19 VGEGAYGTVCSAIHKPTNTKVAIKKI-QPFSRSMFVTRTLRELKLLKFFHSHENIISVLD 77
+G+GAYG VCSA++ TN VAIKKI F + RTLRE+KLL+ HENI+++ D
Sbjct: 69 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHM-DHENIVAIRD 127
Query: 78 IVRPTSWHKFEAVYLVQELMETDLQKII-NQQNLSEDHIQYFVYQILRALKSLHSAQVIH 136
I+ P + F VY+ ELM+TDL +II + Q LSE+H QYF+YQILR LK +HSA V+H
Sbjct: 128 IIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLH 187
Query: 137 RDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRAPEIMLSFQ 196
RDLKPSNLLLN+NCDLK+CDFGLAR + SD FMTEYV TRWYRAPE++L+
Sbjct: 188 RDLKPSNLLLNANCDLKICDFGLARVTSESD--------FMTEYVVTRWYRAPELLLNSS 239
Query: 197 EYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQIKSKRAKEY 256
+YT A+D+WS GCI E++ KPLFPG+D+ HQL +++E++G+P+ E+ E + ++ AK Y
Sbjct: 240 DYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFL-NENAKRY 298
Query: 257 ISQLPMKKGIPWANVLNK--EVNPLAIDLLSKMLTFNPDKRISAVEALEHPYLATYHDPD 314
I QLP P ++ +K V+PLAIDL+ KMLTF+P +RI+ ++AL HPYL + HD
Sbjct: 299 IRQLP---PYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDIS 355
Query: 315 DEPDYPQLNLEDNFWKIDNEARDKNEEDDIPLELLKKMLYGEVM 358
DE P+ + NF +N A + E +K+++Y E +
Sbjct: 356 DE---PECTIPFNF-DFENHALSE--------EQMKELIYREAL 387
>SPAC24B11.06c [T] KOG0660 Mitogen-activated protein kinase
Length = 349
Score = 317 bits (811), Expect = 2e-86
Identities = 177/355 (49%), Positives = 230/355 (63%), Gaps = 33/355 (9%)
Query: 7 YDIPSHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKI-QPFSRSMFVTRTLRELKLLKF 65
++I + Y + +G GA+G VCSA + T VA+KKI +PFS + RT RELKLLK
Sbjct: 14 FEITTRYSDLQPIGMGAFGLVCSAKDQLTGMNVAVKKIMKPFSTPVLAKRTYRELKLLKH 73
Query: 66 FHSHENIISVLDI-VRPTSWHKFEAVYLVQELMETDLQKIINQQNLSEDHIQYFVYQILR 124
HENIIS+ DI + P FE +Y V EL+ TDL +++ + L IQYF+YQILR
Sbjct: 74 LR-HENIISLSDIFISP-----FEDIYFVTELLGTDLHRLLTSRPLETQFIQYFLYQILR 127
Query: 125 ALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATR 184
LK +HSA VIHRDLKPSN+L+N NCDLK+CDFGLAR MT YV+TR
Sbjct: 128 GLKFVHSAGVIHRDLKPSNILINENCDLKICDFGLARIQDPQ----------MTGYVSTR 177
Query: 185 WYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLED 244
+YRAPEIML++Q+Y +DIWS GCI AEMI GKPLFPG+D+ +Q II E+LG+P +E
Sbjct: 178 YYRAPEIMLTWQKYNVEVDIWSAGCIFAEMIEGKPLFPGRDHVNQFSIITELLGTPPMEV 237
Query: 245 FEQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEH 304
E I SK ++ LP K+ +P+A K +P AIDLL KML F+P KRISA +AL H
Sbjct: 238 IETICSKNTLRFVQSLPQKEKVPFAEKF-KNADPDAIDLLEKMLVFDPRKRISAADALAH 296
Query: 305 PYLATYHDPDDEPDYPQLNLEDNFWKIDNEARDKN-EEDDIPLELLKKMLYGEVM 358
YLA YHDP DEP + +E D + +++D+P+E K M+Y EV+
Sbjct: 297 NYLAPYHDPTDEP-------------VADEVFDWSFQDNDLPVETWKVMMYSEVL 338
>SPBC119.08 [T] KOG0660 Mitogen-activated protein kinase
Length = 422
Score = 316 bits (809), Expect = 4e-86
Identities = 169/315 (53%), Positives = 217/315 (68%), Gaps = 13/315 (4%)
Query: 9 IPSHYQLVDLVGEGAYGTVCSA--IHKPTNTKVAIKKI-QPFSRSMFVTRTLRELKLLKF 65
+ ++++V +G+GAYG VC+A + VAIKKI FS+S+ R LRE+KLL
Sbjct: 17 VEPNFKVVKELGQGAYGIVCAARNVASKDQEAVAIKKITNVFSKSILTKRALREIKLLIH 76
Query: 66 FHSHENIISV--LDIVRPTSWHKFEAVYLVQELMETDLQKIINQ-QNLSEDHIQYFVYQI 122
F +H NI + LDI+ P + F VY+ +ELME DL II Q L++ H Q F+YQI
Sbjct: 77 FRNHRNITCIYDLDIINP---YNFNEVYIYEELMEADLNAIIKSGQPLTDAHFQSFIYQI 133
Query: 123 LRALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVA 182
L LK +HSA VIHRDLKP NLL+N++C+LK+CDFGLAR S+ EN GFMTEYVA
Sbjct: 134 LCGLKYIHSANVIHRDLKPGNLLVNADCELKICDFGLAR--GCSENPEENP-GFMTEYVA 190
Query: 183 TRWYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTL 242
TRWYRAPEIMLSF Y +D+WS GCILAE++ G PLF GKD+ HQL +IL LG+P
Sbjct: 191 TRWYRAPEIMLSFSSYHKGIDVWSVGCILAELLGGTPLFKGKDFVHQLNLILHQLGTPDE 250
Query: 243 EDFEQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEAL 302
E I S RA+EY+ LP ++ IP+ K NPLA+DLL+K+L F+P++RIS +AL
Sbjct: 251 ETLSHISSSRAQEYVRSLPKQRPIPFETNFPK-ANPLALDLLAKLLAFDPNRRISVDDAL 309
Query: 303 EHPYLATYHDPDDEP 317
EHPYLA +HDP DEP
Sbjct: 310 EHPYLAVWHDPSDEP 324
>7298087 [T] KOG0660 Mitogen-activated protein kinase
Length = 365
Score = 315 bits (807), Expect = 7e-86
Identities = 171/356 (48%), Positives = 231/356 (64%), Gaps = 30/356 (8%)
Query: 7 YDIPSHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKI-QPFSRSMFVTRTLRELKLLKF 65
++IP YQ + VG+GAYG VC A+ + T+TKVAIKK+ +PF ++ RT REL+LLK
Sbjct: 18 WEIPETYQNLQPVGQGAYGQVCKAVVRGTSTKVAIKKLARPFQSAVHAKRTYRELRLLKH 77
Query: 66 FHSHENIISVLDIVRP----TSWHKFEAVYLVQELMETDLQKIINQQNLSEDHIQYFVYQ 121
HEN+I +LD+ P S +F+ VY+V LM+ DL II Q LS+DH+Q+ VYQ
Sbjct: 78 M-DHENVIGLLDVFHPGQPADSLDQFQQVYMVTHLMDADLNNIIRTQKLSDDHVQFLVYQ 136
Query: 122 ILRALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYV 181
ILR LK +HSA VIHRDLKPSN+ +N +C+L++ DFGLAR S MT YV
Sbjct: 137 ILRGLKYIHSAGVIHRDLKPSNIAVNEDCELRILDFGLARPAESE----------MTGYV 186
Query: 182 ATRWYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPT 241
ATRWYRAPEIML++ Y DIWS GCI+AE++ G+ LFPG D+ HQL +I+EVLG+P
Sbjct: 187 ATRWYRAPEIMLNWMHYNQTADIWSVGCIMAELLTGRTLFPGTDHIHQLNLIMEVLGTPA 246
Query: 242 LEDFEQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEA 301
E +I S+ A+ YI LP+ + ++ + NPLAIDLL KML + DKRI+A +A
Sbjct: 247 DEFMSRISSESARNYIRSLPVMPRRNFRDIF-RGANPLAIDLLEKMLELDADKRITAEQA 305
Query: 302 LEHPYLATYHDPDDEPDYPQLNLEDNFWKIDNEARDKNEEDDIPLELLKKMLYGEV 357
L HPY+ YHDP DE L D + EE+++P+E ++M++ EV
Sbjct: 306 LAHPYMEKYHDPTDE---QTAALYDQSF----------EENELPVEKWREMVFSEV 348
>At1g59580 [T] KOG0660 Mitogen-activated protein kinase
Length = 376
Score = 308 bits (790), Expect = 6e-84
Identities = 162/354 (45%), Positives = 233/354 (65%), Gaps = 22/354 (6%)
Query: 7 YDIPSHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQP-FSRSMFVTRTLRELKLLKF 65
++I + Y + +G GAYG VCS++++ +N +VAIKKI F + RTLRELKLL+
Sbjct: 26 FEIDTKYVPIKPIGRGAYGVVCSSVNRESNERVAIKKIHNVFENRIDALRTLRELKLLRH 85
Query: 66 FHSHENIISVLDIVRPTSWHKFEAVYLVQELMETDLQKII-NQQNLSEDHIQYFVYQILR 124
HEN++++ D++ F+ VYLV ELM+TDL +II + Q LS DH QYF++Q+LR
Sbjct: 86 LR-HENVVALKDVMMANHKRSFKDVYLVYELMDTDLHQIIKSSQVLSNDHCQYFLFQLLR 144
Query: 125 ALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATR 184
LK +HSA ++HRDLKP NLL+N+NCDLK+CDFGLAR + Q FMTEYV TR
Sbjct: 145 GLKYIHSANILHRDLKPGNLLVNANCDLKICDFGLARTSNTKGQ-------FMTEYVVTR 197
Query: 185 WYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLED 244
WYRAPE++L Y T++D+WS GCI AE++ KP+FPG + +Q+ +I+ +LGS ED
Sbjct: 198 WYRAPELLLCCDNYGTSIDVWSVGCIFAELLGRKPVFPGTECLNQIKLIINILGSQREED 257
Query: 245 FEQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEH 304
E I + +AK YI LP GI ++ L N LAIDLL KML +P KRIS EAL+H
Sbjct: 258 LEFIDNPKAKRYIESLPYSPGISFSR-LYPGANVLAIDLLQKMLVLDPSKRISVTEALQH 316
Query: 305 PYLATYHDPDDEPDYPQLNLEDNFWKIDNEARDKNEEDDIPLELLKKMLYGEVM 358
PY+A +DP P Q+ ++ D +E++D+ E+++++++ E++
Sbjct: 317 PYMAPLYDPSANPP-AQVPID----------LDVDEDEDLGAEMIRELMWKEMI 359
>7301110 [T] KOG0660 Mitogen-activated protein kinase
Length = 366
Score = 308 bits (790), Expect = 6e-84
Identities = 171/356 (48%), Positives = 225/356 (63%), Gaps = 30/356 (8%)
Query: 7 YDIPSHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKI-QPFSRSMFVTRTLRELKLLKF 65
++IP YQ + VG GAYG V A+ + TN VAIKK+ +PF ++ RT REL+LLK
Sbjct: 19 WEIPDIYQDLQPVGSGAYGQVSKAVVRGTNMHVAIKKLARPFQSAVHAKRTYRELRLLKH 78
Query: 66 FHSHENIISVLDIVRPT----SWHKFEAVYLVQELMETDLQKIINQQNLSEDHIQYFVYQ 121
HEN+I +LDI P S F+ VYLV LM+ DL II Q+LS+DH+Q+ VYQ
Sbjct: 79 M-DHENVIGLLDIFHPHPANGSLENFQQVYLVTHLMDADLNNIIRMQHLSDDHVQFLVYQ 137
Query: 122 ILRALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYV 181
ILR LK +HSA VIHRDLKPSN+ +N +C+L++ DFGLAR + MT YV
Sbjct: 138 ILRGLKYIHSAGVIHRDLKPSNIAVNEDCELRILDFGLARPTENE----------MTGYV 187
Query: 182 ATRWYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPT 241
ATRWYRAPEIML++ Y +DIWS GCI+AE+I + LFPG D+ HQL +I+E+LG+P
Sbjct: 188 ATRWYRAPEIMLNWMHYDQTVDIWSVGCIMAELITRRTLFPGTDHIHQLNLIMEMLGTPP 247
Query: 242 LEDFEQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEA 301
E ++I S+ A+ YI LP KG + NV K NPLAIDLL KML + +KRI+A EA
Sbjct: 248 AEFLKKISSESARSYIQSLPPMKGRSFKNVF-KNANPLAIDLLEKMLELDAEKRITAEEA 306
Query: 302 LEHPYLATYHDPDDEPDYPQLNLEDNFWKIDNEARDKNEEDDIPLELLKKMLYGEV 357
L HPYL Y +P E P + E+ D+P++ K+++Y EV
Sbjct: 307 LSHPYLEKYAEPSVEQTSPPYD-------------HSFEDMDLPVDKWKELIYKEV 349
>At2g18170 [T] KOG0660 Mitogen-activated protein kinase
Length = 368
Score = 306 bits (785), Expect = 2e-83
Identities = 157/313 (50%), Positives = 215/313 (68%), Gaps = 11/313 (3%)
Query: 7 YDIPSHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQP-FSRSMFVTRTLRELKLLKF 65
++I + Y + +G GAYG VCS+I++ TN +VAIKKI F + RTLRELKLL+
Sbjct: 26 FEIDTKYVPIKPIGRGAYGVVCSSINRETNERVAIKKIHNVFENRVDALRTLRELKLLRH 85
Query: 66 FHSHENIISVLDIVRPTSWHKFEAVYLVQELMETDLQKII-NQQNLSEDHIQYFVYQILR 124
HEN+I++ D++ P + F+ VYLV ELM+TDL +II + Q+LS+DH +YF++Q+LR
Sbjct: 86 VR-HENVIALKDVMLPANRSSFKDVYLVYELMDTDLHQIIKSSQSLSDDHCKYFLFQLLR 144
Query: 125 ALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATR 184
LK LHSA ++HRDLKP NLL+N+NCDLK+CDFGLAR ++Q FMTEYV TR
Sbjct: 145 GLKYLHSANILHRDLKPGNLLVNANCDLKICDFGLARTSQGNEQ-------FMTEYVVTR 197
Query: 185 WYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLED 244
WYRAPE++L Y T++D+WS GCI AE++ KP+FPG + +QL +I+ V+GS D
Sbjct: 198 WYRAPELLLCCDNYGTSIDVWSVGCIFAEILGRKPIFPGTECLNQLKLIINVVGSQQESD 257
Query: 245 FEQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEH 304
I + +A+ +I LP +G +N L + NPLAIDLL +ML F+P KRIS +AL H
Sbjct: 258 IRFIDNPKARRFIKSLPYSRGTHLSN-LYPQANPLAIDLLQRMLVFDPTKRISVTDALLH 316
Query: 305 PYLATYHDPDDEP 317
PY+A DP P
Sbjct: 317 PYMAGLFDPGSNP 329
>At3g59790 [T] KOG0660 Mitogen-activated protein kinase
Length = 393
Score = 306 bits (784), Expect = 3e-83
Identities = 163/317 (51%), Positives = 220/317 (68%), Gaps = 18/317 (5%)
Query: 7 YDIPSHYQL-VDLVGEGAYGTVCSAIHKPTNTKVAIKKI-QPFSRSMFVTRTLRELKLLK 64
+++P+ Y+ + +G GA G VCSA+ TN KVAIKKI Q F ++ RTLRE+KLL+
Sbjct: 53 FELPAKYKPPIRPIGRGACGIVCSAVDSETNEKVAIKKITQVFDNTIEAKRTLREIKLLR 112
Query: 65 FFHSHENIISVLDIVRPTSWHKFEAVYLVQELMETDLQKII-NQQNLSEDHIQYFVYQIL 123
F HENI+++ D++ P FE VY+V ELME DL + + + Q L++DH YF+YQIL
Sbjct: 113 HF-DHENIVAIRDVILPPQRDSFEDVYIVNELMEFDLYRTLKSDQELTKDHGMYFMYQIL 171
Query: 124 RALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVAT 183
R LK +HSA V+HRDLKPSNLLL++ CDLK+CDFGLAR S+ MTEYV T
Sbjct: 172 RGLKYIHSANVLHRDLKPSNLLLSTQCDLKICDFGLARATPESN--------LMTEYVVT 223
Query: 184 RWYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLE 243
RWYRAPE++L +YT A+D+WS GCI E++ +PLFPGKD +QL ++LE++G+P+ E
Sbjct: 224 RWYRAPELLLGSSDYTAAIDVWSVGCIFMEIMNREPLFPGKDQVNQLRLLLELIGTPSEE 283
Query: 244 DFEQIKSKRAKEYISQLPMKKGIPWANVLNK--EVNPLAIDLLSKMLTFNPDKRISAVEA 301
+ + S+ AK YI QLP +P + K V PLAIDL+ KMLTF+P +RIS EA
Sbjct: 284 ELGSL-SEYAKRYIRQLPT---LPRQSFTEKFPNVPPLAIDLVEKMLTFDPKQRISVKEA 339
Query: 302 LEHPYLATYHDPDDEPD 318
L HPYL+++HD DEP+
Sbjct: 340 LAHPYLSSFHDITDEPE 356
>At1g10210 [T] KOG0660 Mitogen-activated protein kinase
Length = 370
Score = 306 bits (783), Expect = 4e-83
Identities = 164/354 (46%), Positives = 231/354 (64%), Gaps = 24/354 (6%)
Query: 7 YDIPSHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQP-FSRSMFVTRTLRELKLLKF 65
++I + Y + +G GAYG VCS+++ TN KVAIKKI + + RTLRELKLL+
Sbjct: 26 FEIDTKYMPIKPIGRGAYGVVCSSVNSDTNEKVAIKKIHNVYENRIDALRTLRELKLLRH 85
Query: 66 FHSHENIISVLDIVRPTSWHKFEAVYLVQELMETDLQKII-NQQNLSEDHIQYFVYQILR 124
HEN+I++ D++ P F+ VYLV ELM+TDL +II + Q LS DH QYF++Q+LR
Sbjct: 86 LR-HENVIALKDVMMPIHKMSFKDVYLVYELMDTDLHQIIKSSQVLSNDHCQYFLFQLLR 144
Query: 125 ALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATR 184
LK +HSA ++HRDLKP NLL+N+NCDLK+CDFGLAR + Q FMTEYV TR
Sbjct: 145 GLKYIHSANILHRDLKPGNLLVNANCDLKICDFGLARASNTKGQ-------FMTEYVVTR 197
Query: 185 WYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLED 244
WYRAPE++L Y T++D+WS GCI AE++ KP+F G + +QL +I+ +LGS ED
Sbjct: 198 WYRAPELLLCCDNYGTSIDVWSVGCIFAELLGRKPIFQGTECLNQLKLIVNILGSQREED 257
Query: 245 FEQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEH 304
E I + +AK YI LP G+ + L + LAIDLL KML F+P KRIS EAL+H
Sbjct: 258 LEFIDNPKAKRYIRSLPYSPGMSLSR-LYPGAHVLAIDLLQKMLVFDPSKRISVSEALQH 316
Query: 305 PYLATYHDPDDEPDYPQLNLEDNFWKIDNEARDKNEEDDIPLELLKKMLYGEVM 358
PY+A +DP+ P Q+ + D + ++D+ E++++M++ E++
Sbjct: 317 PYMAPLYDPNANPP-AQVPI------------DLDVDEDLREEMIREMMWNEML 357
>Hs20986512 [T] KOG0660 Mitogen-activated protein kinase
Length = 360
Score = 302 bits (774), Expect = 4e-82
Identities = 157/313 (50%), Positives = 209/313 (66%), Gaps = 14/313 (4%)
Query: 7 YDIPSHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKI-QPFSRSMFVTRTLRELKLLKF 65
+++P YQ + VG GAYG+VC+A T +VA+KK+ +PF + RT REL+LLK
Sbjct: 18 WEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKH 77
Query: 66 FHSHENIISVLDIVRPT-SWHKFEAVYLVQELMETDLQKIINQQNLSEDHIQYFVYQILR 124
HEN+I +LD+ P S +F VYLV LM DL I+ Q L++DH+Q+ +YQILR
Sbjct: 78 M-KHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILR 136
Query: 125 ALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATR 184
LK +HSA +IHRDLKPSNL +N +C+LK+ DFGLAR + D+ MT YVATR
Sbjct: 137 GLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR--HTDDE--------MTGYVATR 186
Query: 185 WYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLED 244
WYRAPEIML++ Y +DIWS GCI+AE++ G+ LFPG D+ QL +IL ++G+P E
Sbjct: 187 WYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAEL 246
Query: 245 FEQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEH 304
++I S+ A+ YI L + +ANV NPLA+DLL KML + DKRI+A +AL H
Sbjct: 247 LKKISSESARNYIQSLTQMPKMNFANVF-IGANPLAVDLLEKMLVLDSDKRITAAQALAH 305
Query: 305 PYLATYHDPDDEP 317
Y A YHDPDDEP
Sbjct: 306 AYFAQYHDPDDEP 318
>YLR113w [T] KOG0660 Mitogen-activated protein kinase
Length = 435
Score = 301 bits (772), Expect = 8e-82
Identities = 169/353 (47%), Positives = 225/353 (62%), Gaps = 29/353 (8%)
Query: 7 YDIPSHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKI-QPFSRSMFVTRTLRELKLLKF 65
++I + Y ++ VG GA+G VCSA T+ VAIKKI +PFS ++ RT RELKLLK
Sbjct: 17 FEITNRYNDLNPVGMGAFGLVCSATDTLTSQPVAIKKIMKPFSTAVLAKRTYRELKLLKH 76
Query: 66 FHSHENIISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQNLSEDHIQYFVYQILRA 125
HEN+I + DI E +Y V EL TDL +++ + L + +QYF+YQILR
Sbjct: 77 LR-HENLICLQDIFLSP----LEDIYFVTELQGTDLHRLLQTRPLEKQFVQYFLYQILRG 131
Query: 126 LKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRW 185
LK +HSA VIHRDLKPSN+L+N NCDLK+CDFGLAR MT YV+TR+
Sbjct: 132 LKYVHSAGVIHRDLKPSNILINENCDLKICDFGLARIQDPQ----------MTGYVSTRY 181
Query: 186 YRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDF 245
YRAPEIML++Q+Y +DIWS GCI AEMI GKPLFPGKD+ HQ II ++LGSP +
Sbjct: 182 YRAPEIMLTWQKYDVEVDIWSAGCIFAEMIEGKPLFPGKDHVHQFSIITDLLGSPPKDVI 241
Query: 246 EQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEHP 305
I S+ ++++ LP + IP++ K V P A+DLL KML F+P KRI+A +AL HP
Sbjct: 242 NTICSENTLKFVTSLPHRDPIPFSERF-KTVEPDAVDLLEKMLVFDPKKRITAADALAHP 300
Query: 306 YLATYHDPDDEPDYPQLNLEDNFWKIDNEARDKNEEDDIPLELLKKMLYGEVM 358
Y A YHDP DEP + +F N+A D+P++ + M+Y E++
Sbjct: 301 YSAPYHDPTDEP-VADAKFDWHF----NDA-------DLPVDTWRVMMYSEIL 341
>At1g07880 [T] KOG0660 Mitogen-activated protein kinase
Length = 363
Score = 301 bits (772), Expect = 8e-82
Identities = 156/307 (50%), Positives = 207/307 (66%), Gaps = 12/307 (3%)
Query: 16 VDLVGEGAYGTVCSAIHKPTNTKVAIKKI-QPFSRSMFVTRTLRELKLLKFFHSHENIIS 74
++ +G GAYG VC A + TN +VAIKKI F + RTLRE+KLL H+N+I
Sbjct: 36 IEPIGRGAYGIVCCATNSETNEEVAIKKIANAFDNRVDAKRTLREIKLLSHM-DHDNVIK 94
Query: 75 VLDIVRPTSWHKFEAVYLVQELMETDLQKIINQ-QNLSEDHIQYFVYQILRALKSLHSAQ 133
+ DI+ +FE VY+V ELM+TDL +II Q L++DH QYF+YQILR LK +HSA
Sbjct: 95 IKDIIELPEKERFEDVYIVYELMDTDLHQIIRSTQTLTDDHCQYFLYQILRGLKYIHSAN 154
Query: 134 VIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRAPEIML 193
V+HRDLKPSNL+LN+NCDLK+CDFGLAR N MTEYV TRWYRAPE++L
Sbjct: 155 VLHRDLKPSNLVLNTNCDLKICDFGLART--------SNETEIMTEYVVTRWYRAPELLL 206
Query: 194 SFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQIKSKRA 253
+ EYT A+DIWS GCI E++ + LFPGKDY QL +I E+LGSP D + ++S A
Sbjct: 207 NSSEYTGAIDIWSVGCIFMEILRRETLFPGKDYVQQLKLITELLGSPDDSDLDFLRSDNA 266
Query: 254 KEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEHPYLATYHDP 313
++Y+ QLP + + ++P+A+DL KML F+P KRI+ EAL+ PYLA+ H+
Sbjct: 267 RKYVKQLPHVQKQSFREKF-PNISPMALDLAEKMLVFDPSKRITVDEALKQPYLASLHEI 325
Query: 314 DDEPDYP 320
++EP P
Sbjct: 326 NEEPTCP 332
>At4g36450 [T] KOG0660 Mitogen-activated protein kinase
Length = 361
Score = 300 bits (768), Expect = 2e-81
Identities = 163/356 (45%), Positives = 233/356 (64%), Gaps = 30/356 (8%)
Query: 7 YDIPSHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQP-FSRSMFVTRTLRELKLLKF 65
++I + Y + +G GAYG VCS+I+ TN +VAIKKI F + RTLRELKLL+
Sbjct: 26 FEIDTKYVPIKPIGRGAYGVVCSSINSETNERVAIKKIHNVFENRIDALRTLRELKLLRH 85
Query: 66 FHSHENIISVLDIVRPTSWHKFEAVYLVQELMETDLQKII-NQQNLSEDHIQYFVYQILR 124
HEN+IS+ D++ PT + F VYLV ELM++DL +II + Q+LS+DH +YF++Q+LR
Sbjct: 86 VR-HENVISLKDVMLPTHRYSFRDVYLVYELMDSDLNQIIKSSQSLSDDHCKYFLFQLLR 144
Query: 125 ALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATR 184
LK LHSA ++HRDLKP NLL+N+NCDLK+CDFGLAR FMTEYV TR
Sbjct: 145 GLKYLHSANILHRDLKPGNLLVNANCDLKICDFGLARTYEQ----------FMTEYVVTR 194
Query: 185 WYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLED 244
WYRAPE++L Y T++D+WS GCI AE++ KP+FPG + +QL +I+ V+GS D
Sbjct: 195 WYRAPELLLCCDNYGTSIDVWSVGCIFAEILGRKPIFPGTECLNQLKLIINVVGSQQDWD 254
Query: 245 FEQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEH 304
+ I +++A+ +I LP KG ++++ NPLAIDLL +ML F+P KRIS +AL H
Sbjct: 255 LQFIDNQKARRFIKSLPFSKGTHFSHIY-PHANPLAIDLLQRMLVFDPTKRISVSDALLH 313
Query: 305 PYLATYHDPDDEP--DYPQLNLEDNFWKIDNEARDKNEEDDIPLELLKKMLYGEVM 358
PY+ +P+ P + P +LE D+N E D ++++M++ E++
Sbjct: 314 PYMEGLLEPECNPSENVPVSSLE----------IDENMEGD----MIREMMWEEML 355
>YHR030c [T] KOG0660 Mitogen-activated protein kinase
Length = 484
Score = 299 bits (766), Expect = 4e-81
Identities = 164/318 (51%), Positives = 212/318 (66%), Gaps = 13/318 (4%)
Query: 7 YDIPSHYQLVDLVGEGAYGTVCSA--IHKPTNTKVAIKKI-QPFSRSMFVTRTLRELKLL 63
+ + +QL+ +G GAYG VCSA +T VAIKK+ FS+++ R+LRELKLL
Sbjct: 17 FSVDKRFQLIKEIGHGAYGIVCSARFAEAAEDTTVAIKKVTNVFSKTLLCKRSLRELKLL 76
Query: 64 KFFHSHENIISVLD---IVRPTSWHKFEAVYLVQELMETDLQKIINQ-QNLSEDHIQYFV 119
+ F H+NI + D + P +YL +ELME D+ +II Q L++ H Q F
Sbjct: 77 RHFRGHKNITCLYDMDIVFYPDG--SINGLYLYEELMECDMHQIIKSGQPLTDAHYQSFT 134
Query: 120 YQILRALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTE 179
YQIL LK +HSA V+HRDLKP NLL+N++C LK+CDFGLAR S+ EN F+TE
Sbjct: 135 YQILCGLKYIHSADVLHRDLKPGNLLVNADCQLKICDFGLAR--GYSENPVENSQ-FLTE 191
Query: 180 YVATRWYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGS 239
YVATRWYRAPEIMLS+Q YT A+D+WS GCILAE + GKP+F GKDY +QL IL+VLG+
Sbjct: 192 YVATRWYRAPEIMLSYQGYTKAIDVWSAGCILAEFLGGKPIFKGKDYVNQLNQILQVLGT 251
Query: 240 PTLEDFEQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAV 299
P E +I SK ++YI QL +P+ N L N A+DLL +ML F+P KRI+
Sbjct: 252 PPDETLRRIGSKNVQDYIHQLGFIPKVPFVN-LYPNANSQALDLLEQMLAFDPQKRITVD 310
Query: 300 EALEHPYLATYHDPDDEP 317
EALEHPYL+ +HDP DEP
Sbjct: 311 EALEHPYLSIWHDPADEP 328
>At4g01370 [T] KOG0660 Mitogen-activated protein kinase
Length = 376
Score = 298 bits (764), Expect = 6e-81
Identities = 159/303 (52%), Positives = 207/303 (67%), Gaps = 16/303 (5%)
Query: 19 VGEGAYGTVCSAIHKPTNTKVAIKKI-QPFSRSMFVTRTLRELKLLKFFHSHENIISVLD 77
+G GAYG VC+A + T +VAIKKI F + RTLRE+KLLK HEN+I+V D
Sbjct: 49 IGRGAYGIVCAATNSETGEEVAIKKIGNAFDNIIDAKRTLREIKLLKHM-DHENVIAVKD 107
Query: 78 IVRPTSWHKFEAVYLVQELMETDLQKII-NQQNLSEDHIQYFVYQILRALKSLHSAQVIH 136
I++P F VY+V ELM+TDL +II + Q L++DH ++F+YQ+LR LK +HSA V+H
Sbjct: 108 IIKPPQRENFNDVYIVYELMDTDLHQIIRSNQPLTDDHCRFFLYQLLRGLKYVHSANVLH 167
Query: 137 RDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRAPEIMLSFQ 196
RDLKPSNLLLN+NCDLK+ DFGLAR + +D FMTEYV TRWYRAPE++L+
Sbjct: 168 RDLKPSNLLLNANCDLKLGDFGLARTKSETD--------FMTEYVVTRWYRAPELLLNCS 219
Query: 197 EYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQIKSKRAKEY 256
EYT A+DIWS GCIL E + +PLFPGKDY HQL +I E++GSP ++S A+ Y
Sbjct: 220 EYTAAIDIWSVGCILGETMTREPLFPGKDYVHQLRLITELIGSPDDSSLGFLRSDNARRY 279
Query: 257 ISQLPMKKGIPWANVLNK--EVNPLAIDLLSKMLTFNPDKRISAVEALEHPYLATYHDPD 314
+ QLP P N + ++ A+DLL KML F+P +RI+ EAL HPYLA HD +
Sbjct: 280 VRQLPQ---YPRQNFAARFPNMSAGAVDLLEKMLVFDPSRRITVDEALCHPYLAPLHDIN 336
Query: 315 DEP 317
+EP
Sbjct: 337 EEP 339
>Hs20128774 [T] KOG0660 Mitogen-activated protein kinase
Length = 364
Score = 296 bits (757), Expect = 4e-80
Identities = 156/314 (49%), Positives = 208/314 (65%), Gaps = 14/314 (4%)
Query: 7 YDIPSHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKI-QPFSRSMFVTRTLRELKLLKF 65
+++P Q + VG GAYG+VCSA KVA+KK+ +PF + RT REL+LLK
Sbjct: 18 WEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKH 77
Query: 66 FHSHENIISVLDIVRP-TSWHKFEAVYLVQELMETDLQKIINQQNLSEDHIQYFVYQILR 124
HEN+I +LD+ P TS F VYLV LM DL I+ Q LS++H+Q+ VYQ+LR
Sbjct: 78 L-KHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLR 136
Query: 125 ALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATR 184
LK +HSA +IHRDLKPSN+ +N +C+L++ DFGLAR Q+ E M G YVATR
Sbjct: 137 GLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLAR------QADEEMTG----YVATR 186
Query: 185 WYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLED 244
WYRAPEIML++ Y +DIWS GCI+AE++ GK LFPG DY QL I+EV+G+P+ E
Sbjct: 187 WYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEV 246
Query: 245 FEQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEH 304
+I S+ A+ YI LP +++ + NPLAIDLL +ML + D+R+SA EAL H
Sbjct: 247 LAKISSEHARTYIQSLPPMPQKDLSSIF-RGANPLAIDLLGRMLVLDSDQRVSAAEALAH 305
Query: 305 PYLATYHDPDDEPD 318
Y + YHDP+DEP+
Sbjct: 306 AYFSQYHDPEDEPE 319
>Hs4503069 [T] KOG0660 Mitogen-activated protein kinase
Length = 360
Score = 295 bits (756), Expect = 5e-80
Identities = 154/313 (49%), Positives = 205/313 (65%), Gaps = 14/313 (4%)
Query: 7 YDIPSHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKI-QPFSRSMFVTRTLRELKLLKF 65
+++P YQ + VG GAYG+VC+A T +VA+KK+ +PF + RT REL+LLK
Sbjct: 18 WEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKH 77
Query: 66 FHSHENIISVLDIVRPT-SWHKFEAVYLVQELMETDLQKIINQQNLSEDHIQYFVYQILR 124
HEN+I +LD+ P S +F VYLV LM DL I+ Q L++DH+Q+ +YQILR
Sbjct: 78 M-KHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILR 136
Query: 125 ALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATR 184
LK +HSA +IHRDLKPSNL +N +C+LK+ DFGLAR + D+ MT YVATR
Sbjct: 137 GLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR--HTDDE--------MTGYVATR 186
Query: 185 WYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLED 244
WYRAPEIML++ Y +DIWS GCI+AE++ G+ LFPG D+ +QL I+ + G+P
Sbjct: 187 WYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPAYL 246
Query: 245 FEQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEH 304
++ S A+ YI L + +ANV NPLA+DLL KML + DKRI+A +AL H
Sbjct: 247 INRMPSHEARNYIQSLTQMPKMNFANVF-IGANPLAVDLLEKMLVLDSDKRITAAQALAH 305
Query: 305 PYLATYHDPDDEP 317
Y A YHDPDDEP
Sbjct: 306 AYFAQYHDPDDEP 318
>CE06686 [T] KOG0660 Mitogen-activated protein kinase
Length = 377
Score = 289 bits (740), Expect = 4e-78
Identities = 158/321 (49%), Positives = 207/321 (64%), Gaps = 14/321 (4%)
Query: 9 IPSHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKI-QPFSRSMFVTRTLRELKLLKFFH 67
+P++Y + +G GAYGTVC+A + T+VAIKK +PF + RT REL+LL+
Sbjct: 31 VPNYYINLTPIGTGAYGTVCAAECTRSGTRVAIKKFNRPFQSIIHARRTYRELRLLRCM- 89
Query: 68 SHENIISVLDIVRPT-SWHKFEAVYLVQELMETDLQKIINQQNLSEDHIQYFVYQILRAL 126
HENII +LD+ P + + E VY V LM DL I+ Q L++DHIQ+ VYQILR L
Sbjct: 90 CHENIIDLLDVFTPNENVNDIEDVYFVSMLMGADLSNILKIQRLNDDHIQFLVYQILRGL 149
Query: 127 KSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWY 186
K +HSA +IHRDLKPSN+ +N +C+LK+ DFGLAR S MT YVATRWY
Sbjct: 150 KYIHSADIIHRDLKPSNIAVNEDCELKILDFGLARQTDSE----------MTGYVATRWY 199
Query: 187 RAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFE 246
RAPEIML++ YT +D+WS GCILAE+I GK LFPG D+ QL I+ V G+P E +
Sbjct: 200 RAPEIMLNWMHYTQTVDVWSVGCILAELITGKTLFPGSDHIDQLTRIMSVTGTPDEEFLK 259
Query: 247 QIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEHPY 306
+I S+ A+ YI LP + L + P AIDLL KML +PD+R +A EA+EH Y
Sbjct: 260 KISSEEARNYIRNLPKMTRRDFKR-LFAQATPQAIDLLEKMLHLDPDRRPTAKEAMEHEY 318
Query: 307 LATYHDPDDEPDYPQLNLEDN 327
LA YHD DEP +++L D+
Sbjct: 319 LAAYHDETDEPIAEEMDLNDD 339
>At4g11330 [T] KOG0660 Mitogen-activated protein kinase
Length = 373
Score = 289 bits (739), Expect = 5e-78
Identities = 152/297 (51%), Positives = 205/297 (68%), Gaps = 16/297 (5%)
Query: 25 GTVCSAIHKPTNTKVAIKKI-QPFSRSMFVTRTLRELKLLKFFHSHENIISVLDIVRPTS 83
G ++ T+ ++AIKKI + F + RTLRE+KLL+ HEN++ + DI+RP
Sbjct: 52 GASVLSVDSETHEEIAIKKIGKAFDNKVDAKRTLREIKLLRHLE-HENVVVIKDIIRPPK 110
Query: 84 WHKFEAVYLVQELMETDLQKII-NQQNLSEDHIQYFVYQILRALKSLHSAQVIHRDLKPS 142
F VY+V ELM+TDL +II + Q+L++DH QYF+YQILR LK +HSA V+HRDLKPS
Sbjct: 111 KEDFVDVYIVFELMDTDLHQIIRSNQSLNDDHCQYFLYQILRGLKYIHSANVLHRDLKPS 170
Query: 143 NLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRAPEIMLSFQEYTTAM 202
NLLLNSNCDLK+ DFGLAR + ++ +MTEYV TRWYRAPE++L+ EYT+A+
Sbjct: 171 NLLLNSNCDLKITDFGLARTTSETE--------YMTEYVVTRWYRAPELLLNSSEYTSAI 222
Query: 203 DIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQIKSKRAKEYISQLPM 262
D+WS GCI AE++ +PLFPGKDY HQL +I E++GSP E ++S A++Y+ +LP
Sbjct: 223 DVWSVGCIFAEIMTREPLFPGKDYVHQLKLITELIGSPDGASLEFLRSANARKYVKELPK 282
Query: 263 KKGIPWANVLNK--EVNPLAIDLLSKMLTFNPDKRISAVEALEHPYLATYHDPDDEP 317
P N + +N AIDLL KML F+P KRI+ EAL +PYL+ HD +DEP
Sbjct: 283 ---FPRQNFSARFPSMNSTAIDLLEKMLVFDPVKRITVEEALCYPYLSALHDLNDEP 336
>At2g46070 [T] KOG0660 Mitogen-activated protein kinase
Length = 406
Score = 286 bits (731), Expect = 4e-77
Identities = 153/301 (50%), Positives = 203/301 (66%), Gaps = 12/301 (3%)
Query: 19 VGEGAYGTVCSAIHKPTNTKVAIKKI-QPFSRSMFVTRTLRELKLLKFFHSHENIISVLD 77
+G GA G VC+A++ T KVAIKKI F + RTLRE+KLL+ HEN+I++ D
Sbjct: 81 IGRGACGIVCAAVNSVTGEKVAIKKIGNAFDNIIDAKRTLREIKLLRHM-DHENVITIKD 139
Query: 78 IVRPTSWHKFEAVYLVQELMETDLQKII-NQQNLSEDHIQYFVYQILRALKSLHSAQVIH 136
IVRP F VY+V ELM+TDLQ+I+ + Q L+ D ++ VYQ+LR LK +HSA ++H
Sbjct: 140 IVRPPQRDIFNDVYIVYELMDTDLQRILRSNQTLTSDQCRFLVYQLLRGLKYVHSANILH 199
Query: 137 RDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRAPEIMLSFQ 196
RDL+PSN+LLNS +LK+ DFGLAR + +D FMTEYV TRWYRAPE++L+
Sbjct: 200 RDLRPSNVLLNSKNELKIGDFGLARTTSDTD--------FMTEYVVTRWYRAPELLLNCS 251
Query: 197 EYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQIKSKRAKEY 256
EYT A+DIWS GCIL E++ G+PLFPGKDY HQL +I E++GSP ++S A+ Y
Sbjct: 252 EYTAAIDIWSVGCILGEIMTGQPLFPGKDYVHQLRLITELVGSPDNSSLGFLRSDNARRY 311
Query: 257 ISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEHPYLATYHDPDDE 316
+ QLP +A K + AIDLL +ML F+P++RIS EAL H YL+ +HD E
Sbjct: 312 VRQLPRYPKQQFAARFPK-MPTTAIDLLERMLVFDPNRRISVDEALGHAYLSPHHDVAKE 370
Query: 317 P 317
P
Sbjct: 371 P 371
>Hs4506085 [T] KOG0660 Mitogen-activated protein kinase
Length = 365
Score = 275 bits (702), Expect = 1e-73
Identities = 150/317 (47%), Positives = 198/317 (62%), Gaps = 15/317 (4%)
Query: 7 YDIPSHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKI-QPFSRSMFVTRTLRELKLLKF 65
+++P Y VG GAYG+VCSAI K + KVAIKK+ +PF +F R REL LLK
Sbjct: 19 WELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLKH 78
Query: 66 FHSHENIISVLDIVRP-TSWHKFEAVYLVQELMETDLQKIINQQNLSEDHIQYFVYQILR 124
HEN+I +LD+ P +S F YLV M+TDLQKI+ + SE+ IQY VYQ+L+
Sbjct: 79 MQ-HENVIGLLDVFTPASSLRNFYDFYLVMPFMQTDLQKIMGME-FSEEKIQYLVYQMLK 136
Query: 125 ALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATR 184
LK +HSA V+HRDLKP NL +N +C+LK+ DFGLAR + MT YV TR
Sbjct: 137 GLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAE----------MTGYVVTR 186
Query: 185 WYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLED 244
WYRAPE++LS+ Y +DIWS GCI+AEM+ GK LF GKDY QL IL+V G P E
Sbjct: 187 WYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEF 246
Query: 245 FEQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEH 304
+++ K AK YI LP + + + +P A DLL KML + DKR++A +AL H
Sbjct: 247 VQKLNDKAAKSYIQSLPQTPRKDFTQLFPR-ASPQAADLLEKMLELDVDKRLTAAQALTH 305
Query: 305 PYLATYHDPDDEPDYPQ 321
P+ + DP++E + Q
Sbjct: 306 PFFEPFRDPEEETEAQQ 322
>At1g18150 [T] KOG0660 Mitogen-activated protein kinase
Length = 589
Score = 273 bits (698), Expect = 3e-73
Identities = 150/357 (42%), Positives = 228/357 (63%), Gaps = 21/357 (5%)
Query: 7 YDIPSHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQP-FSRSMFVTRTLRELKLLKF 65
Y + YQ+ ++VG+G+YG V SA+ T +VAIKKI F TR LRE+KLL+
Sbjct: 98 YGEANRYQIQEVVGKGSYGVVASAVDSHTGERVAIKKINDVFEHVSDATRILREIKLLRL 157
Query: 66 FHSHENIISVLDIVRPTSWHKFEAVYLVQELMETDLQKIIN-QQNLSEDHIQYFVYQILR 124
H +++ + I+ P S +F +Y+V ELME+DL ++I +L+ +H Q+F+YQ+LR
Sbjct: 158 LR-HPDVVEIKHIMLPPSRREFRDIYVVFELMESDLHQVIKANDDLTPEHYQFFLYQLLR 216
Query: 125 ALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATR 184
LK +H+A V HRDLKP N+L N++C LK+CDFGLAR + + F T+YVATR
Sbjct: 217 GLKYVHAANVFHRDLKPKNILANADCKLKICDFGLARVSFNDAPTAI----FWTDYVATR 272
Query: 185 WYRAPEIMLSF-QEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLE 243
WYRAPE+ SF +YT A+DIWS GCI AEM++GKPLFPGK+ HQL ++ + LG+P E
Sbjct: 273 WYRAPELCGSFFSKYTPAIDIWSVGCIFAEMLLGKPLFPGKNVVHQLDLMTDFLGTPPPE 332
Query: 244 DFEQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALE 303
+I++++A+ Y+S + K+ +P+++ K +PLA+ LL ++L F+P R SA +AL
Sbjct: 333 SISRIRNEKARRYLSSMRKKQPVPFSHKFPK-ADPLALRLLERLLAFDPKDRASAEDALA 391
Query: 304 HPYLATYHDPDDEP-DYPQLNLEDNFWKIDNEARDKNEEDDIPLELLKKMLYGEVMK 359
PY + + + EP P LE +F R K +DD+ ++++Y E+++
Sbjct: 392 DPYFSGLSNSEREPTTQPISKLEFDF------ERKKLVKDDV-----RELIYREILE 437
>Hs4506785 [T] KOG0660 Mitogen-activated protein kinase
Length = 367
Score = 273 bits (697), Expect = 4e-73
Identities = 150/354 (42%), Positives = 216/354 (60%), Gaps = 27/354 (7%)
Query: 7 YDIPSHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKI-QPFSRSMFVTRTLRELKLLKF 65
+++ + Y+ + VG GAYG VCSA+ T KVAIKK+ +PF +F R REL+LLK
Sbjct: 21 WEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKH 80
Query: 66 FHSHENIISVLDIVRPT-SWHKFEAVYLVQELMETDLQKIINQQNLSEDHIQYFVYQILR 124
HEN+I +LD+ P + F YLV M TDL K++ + L ED IQ+ VYQ+L+
Sbjct: 81 MR-HENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLK 139
Query: 125 ALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATR 184
L+ +H+A +IHRDLKP NL +N +C+LK+ DFGLAR S MT YV TR
Sbjct: 140 GLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE----------MTGYVVTR 189
Query: 185 WYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLED 244
WYRAPE++L++ YT +DIWS GCI+AEMI GK LF G D+ QL I++V G+P E
Sbjct: 190 WYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEF 249
Query: 245 FEQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEH 304
++++S AK + LP + +A++L +PLA++LL KML + ++R++A EAL H
Sbjct: 250 VQRLQSDEAKNNMKGLPELEKKDFASILT-NASPLAVNLLEKMLVLDAEQRVTAGEALAH 308
Query: 305 PYLATYHDPDDEPDYPQLNLEDNFWKIDNEARDKNEEDDIPLELLKKMLYGEVM 358
PY + HD +DEP + + D ++ D L+ K++ Y EV+
Sbjct: 309 PYFESLHDTEDEPQVQKYD-------------DSFDDVDRTLDEWKRVTYKEVL 349
>At3g18040 [T] KOG0660 Mitogen-activated protein kinase
Length = 613
Score = 271 bits (694), Expect = 8e-73
Identities = 155/357 (43%), Positives = 223/357 (62%), Gaps = 21/357 (5%)
Query: 7 YDIPSHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQP-FSRSMFVTRTLRELKLLKF 65
Y S YQ+ +++G+G+YG V SAI + KVAIKKI F TR LRE+KLL+
Sbjct: 120 YGEASRYQIQEVIGKGSYGVVASAIDTHSGEKVAIKKINDVFEHVSDATRILREIKLLRL 179
Query: 66 FHSHENIISVLDIVRPTSWHKFEAVYLVQELMETDLQKIIN-QQNLSEDHIQYFVYQILR 124
H +I+ + ++ P S +F +Y+V ELME+DL ++I +L+ +H Q+F+YQ+LR
Sbjct: 180 LR-HPDIVEIKHVMLPPSRREFRDIYVVFELMESDLHQVIKANDDLTPEHYQFFLYQLLR 238
Query: 125 ALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATR 184
LK +H+A V HRDLKP N+L NS+C LK+CDFGLAR + S F T+YVATR
Sbjct: 239 GLKFIHTANVFHRDLKPKNILANSDCKLKICDFGLARVSFNDAPSAI----FWTDYVATR 294
Query: 185 WYRAPEIMLSF-QEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLE 243
WYRAPE+ SF +YT A+DIWS GCI AEM+ GKPLFPGK+ HQL I+ ++LG+P E
Sbjct: 295 WYRAPELCGSFFSKYTPAIDIWSIGCIFAEMLTGKPLFPGKNVVHQLDIMTDLLGTPPPE 354
Query: 244 DFEQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALE 303
+I++++A+ Y+ + K +P+ + V+PLA+ LL ++L F+P R SA EAL
Sbjct: 355 AIARIRNEKARRYLGNMRRKPPVPFTHKF-PHVDPLALRLLHRLLAFDPKDRPSAEEALA 413
Query: 304 HPYLATYHDPDDEPD-YPQLNLEDNFWKIDNEARDKNEEDDIPLELLKKMLYGEVMK 359
PY + D EP P LE F E R +ED +++++Y E+++
Sbjct: 414 DPYFYGLANVDREPSTQPIPKLEFEF-----ERRKITKED------VRELIYREILE 459
>At2g42880 [T] KOG0660 Mitogen-activated protein kinase
Length = 594
Score = 270 bits (689), Expect = 3e-72
Identities = 147/340 (43%), Positives = 217/340 (63%), Gaps = 15/340 (4%)
Query: 7 YDIPSHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQP-FSRSMFVTRTLRELKLLKF 65
Y + +++ +++G+G+YG VCSAI T KVAIKKI F R LRE+KLL+
Sbjct: 7 YGDANRFKVQEVIGKGSYGVVCSAIDTLTGEKVAIKKIHDIFEHISDAARILREIKLLRL 66
Query: 66 FHSHENIISVLDIVRPTSWHKFEAVYLVQELMETDLQKIIN-QQNLSEDHIQYFVYQILR 124
H +I+ + I+ P S +F+ +Y+V ELME+DL ++I +L+ +H Q+F+YQ+LR
Sbjct: 67 LR-HPDIVEIKHIMLPPSRREFKDIYVVFELMESDLHQVIKANDDLTREHYQFFLYQLLR 125
Query: 125 ALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATR 184
ALK +H+A V HRDLKP N+L N+NC LK+CDFGLAR + + F T+YVATR
Sbjct: 126 ALKYIHTANVYHRDLKPKNILANANCKLKICDFGLARVAFNDTPTTI----FWTDYVATR 181
Query: 185 WYRAPEIMLSF-QEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLE 243
WYRAPE+ SF +YT A+DIWS GCI AE++MGKPLFPGK+ HQL ++ ++LG+P+L+
Sbjct: 182 WYRAPELCGSFYSKYTPAIDIWSIGCIFAEVLMGKPLFPGKNVVHQLDLMTDLLGTPSLD 241
Query: 244 DFEQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALE 303
++++++A+ Y++ + K IP+A +PL++ LL ++L F+P R +A EAL
Sbjct: 242 TISRVRNEKARRYLTSMRKKPPIPFAQKF-PNADPLSLKLLERLLAFDPKDRPTAEEALA 300
Query: 304 HPYLATYHDPDDEPD-YPQLNLEDNFWKIDNEARDKNEED 342
PY + EP P +E F E R +ED
Sbjct: 301 DPYFKGLAKVEREPSCQPITKMEFEF-----ERRKVTKED 335
>At3g14720 [T] KOG0660 Mitogen-activated protein kinase
Length = 586
Score = 269 bits (687), Expect = 5e-72
Identities = 149/357 (41%), Positives = 225/357 (62%), Gaps = 21/357 (5%)
Query: 7 YDIPSHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQP-FSRSMFVTRTLRELKLLKF 65
Y + Y++++++G+G+YG VC+AI T KVAIKKI F R LRE+KLL+
Sbjct: 7 YGDANRYRILEVIGKGSYGVVCAAIDTQTGEKVAIKKINDVFEHVSDALRILREVKLLRL 66
Query: 66 FHSHENIISVLDIVRPTSWHKFEAVYLVQELMETDLQKIIN-QQNLSEDHIQYFVYQILR 124
H +I+ + I+ P S +F+ +Y+V ELME+DL ++I +L+ +H Q+F+YQ+LR
Sbjct: 67 LR-HPDIVEIKSIMLPPSKREFKDIYVVFELMESDLHQVIKANDDLTREHHQFFLYQMLR 125
Query: 125 ALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATR 184
ALK +H+A V HRDLKP N+L N+NC LKVCDFGLAR + + F T+YVATR
Sbjct: 126 ALKYMHTANVYHRDLKPKNILANANCKLKVCDFGLARVSFNDTPT----TVFWTDYVATR 181
Query: 185 WYRAPEIMLSF-QEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLE 243
WYRAPE+ SF +YT A+DIWS GCI AE++ GKPLFPGK HQL +I ++LG+P E
Sbjct: 182 WYRAPELCGSFCSKYTPAIDIWSIGCIFAEVLTGKPLFPGKSVVHQLDLITDLLGTPKSE 241
Query: 244 DFEQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALE 303
+++++A++Y++++ K +P++ +PLA+ LL ++L F+P R +A EAL
Sbjct: 242 TIAGVRNEKARKYLNEMRKKNLVPFSQKF-PNADPLALRLLQRLLAFDPKDRPTAAEALA 300
Query: 304 HPYLATYHDPDDEPD-YPQLNLEDNFWKIDNEARDKNEEDDIPLELLKKMLYGEVMK 359
PY + EP P +E F R + +DDI ++++Y E+++
Sbjct: 301 DPYFKCLAKVEREPSCQPISKMEFEF------ERRRLTKDDI-----RELIYREILE 346
>At5g19010 [T] KOG0660 Mitogen-activated protein kinase
Length = 567
Score = 268 bits (686), Expect = 7e-72
Identities = 152/357 (42%), Positives = 223/357 (61%), Gaps = 21/357 (5%)
Query: 7 YDIPSHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQP-FSRSMFVTRTLRELKLLKF 65
Y S Y++ +++G+G+YG VCSA T KVAIKKI F TR LRE+KLL+
Sbjct: 19 YGEGSRYRIEEVIGKGSYGVVCSAYDTHTGEKVAIKKINDIFEHVSDATRILREIKLLRL 78
Query: 66 FHSHENIISVLDIVRPTSWHKFEAVYLVQELMETDLQKIIN-QQNLSEDHIQYFVYQILR 124
H +I+ + I+ P S +F +Y+V ELME+DL ++I +L+ +H Q+F+YQ+LR
Sbjct: 79 LR-HPDIVEIKHILLPPSRREFRDIYVVFELMESDLHQVIKANDDLTPEHYQFFLYQLLR 137
Query: 125 ALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATR 184
LK +H+A V HRDLKP N+L N++C LK+CDFGLAR + + F T+YVATR
Sbjct: 138 GLKYIHTANVFHRDLKPKNILANADCKLKICDFGLARVAFNDTPTAI----FWTDYVATR 193
Query: 185 WYRAPEIMLSF-QEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLE 243
WYRAPE+ SF +YT A+DIWS GCI AE++ GKPLFPGK+ HQL ++ ++LG+P+ E
Sbjct: 194 WYRAPELCGSFFSKYTPAIDIWSIGCIFAELLTGKPLFPGKNVVHQLDLMTDMLGTPSAE 253
Query: 244 DFEQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALE 303
++++++A+ Y+S + KK IP+++ +PLA+ LL KML+F P R +A EAL
Sbjct: 254 AIGRVRNEKARRYLSSMRKKKPIPFSHKF-PHTDPLALRLLEKMLSFEPKDRPTAEEALA 312
Query: 304 HPYLATYHDPDDEPD-YPQLNLEDNFWKIDNEARDKNEEDDIPLELLKKMLYGEVMK 359
Y + EP P LE F E R +ED +++++Y E ++
Sbjct: 313 DVYFKGLAKVEREPSAQPVTKLEFEF-----ERRRITKED------VRELIYRESLE 358
>At1g53510 [T] KOG0660 Mitogen-activated protein kinase
Length = 603
Score = 268 bits (685), Expect = 9e-72
Identities = 149/357 (41%), Positives = 228/357 (63%), Gaps = 21/357 (5%)
Query: 7 YDIPSHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQP-FSRSMFVTRTLRELKLLKF 65
Y + Y++++++G+G+YG VC+AI T KVAIKKI F R LRE+KLL+
Sbjct: 7 YGDANRYRILEVIGKGSYGVVCAAIDTHTGEKVAIKKINDVFEHISDALRILREVKLLRL 66
Query: 66 FHSHENIISVLDIVRPTSWHKFEAVYLVQELMETDLQKIIN-QQNLSEDHIQYFVYQILR 124
H +I+ + I+ P S +F+ +Y+V ELME+DL ++I +L+ +H Q+F+YQ+LR
Sbjct: 67 LR-HPDIVEIKSIMLPPSKREFKDIYVVFELMESDLHQVIKANDDLTREHHQFFLYQMLR 125
Query: 125 ALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATR 184
ALK +H+A V HRDLKP N+L N+NC LKVCDFGLAR +A +D F T+YVATR
Sbjct: 126 ALKFMHTANVYHRDLKPKNILANANCKLKVCDFGLAR-VAFNDTP---TTVFWTDYVATR 181
Query: 185 WYRAPEIMLS-FQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLE 243
WYRAPE+ S F +YT A+D+WS GCI AE++ GKPLFPGK HQL +I ++LG+P E
Sbjct: 182 WYRAPELCGSFFSKYTPAIDVWSIGCIFAEVLTGKPLFPGKSVVHQLELITDLLGTPKSE 241
Query: 244 DFEQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALE 303
+++ +A++Y++++ K + ++ +K +PLA+ LL ++L F+P R + EAL
Sbjct: 242 TISGVRNDKARKYLTEMRKKNPVTFSQKFSK-ADPLALRLLQRLLAFDPKDRPTPAEALA 300
Query: 304 HPYLATYHDPDDEPDYPQLN-LEDNFWKIDNEARDKNEEDDIPLELLKKMLYGEVMK 359
PY + EP Q++ +E F R + +DDI ++++Y E+++
Sbjct: 301 DPYFKGLSKIEREPSSQQISKMEFEF------ERRRLTKDDI-----RELIYREILE 346
>CE06762 [T] KOG0660 Mitogen-activated protein kinase
Length = 367
Score = 263 bits (672), Expect = 3e-70
Identities = 146/312 (46%), Positives = 203/312 (64%), Gaps = 7/312 (2%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKI-QPFSRSMFVTRTLRELKLLKFFHSHEN 71
Y + VG GAYG VC A+ +VAIKKI + F+ R+LRE+++L+ HEN
Sbjct: 57 YLAEENVGAGAYGVVCKAMDTRNKKQVAIKKIPRAFTAHTLAKRSLREVRILREL-LHEN 115
Query: 72 IISVLDIVRPTSWHKFEAVYLVQELMETDLQKIIN-QQNLSEDHIQYFVYQILRALKSLH 130
II+VLD+ H + +YLV +LMETDL +I++ +Q L E H QYF YQ+LR LK LH
Sbjct: 116 IIAVLDMFTAEGAHGKD-IYLVMDLMETDLHQILHSRQTLMEQHFQYFFYQLLRGLKYLH 174
Query: 131 SAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRE--NMVGFMTEYVATRWYRA 188
SA +IHRDLKPSNLLLN +C L++ DFG+AR AS+ R+ N+ G MT+YV+TRWYRA
Sbjct: 175 SAGIIHRDLKPSNLLLNGDCLLRIADFGMARAYASASTVRDDANVGGHMTQYVSTRWYRA 234
Query: 189 PEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQI 248
PEI+ S EY T +D+WS GCI AEM++ + LFPGKD Q+ +I+ LGSP E +I
Sbjct: 235 PEILFSMVEYDTKVDLWSAGCIFAEMLLRRQLFPGKDSVSQIKMIVYYLGSPEEEVINRI 294
Query: 249 KSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEHPYLA 308
S ++ I K +P++ + K +P A +++S +L +P KR SA + L+HP++A
Sbjct: 295 TSDLVRDSIEACGRKTPLPFSAIFPK-ASPEARNMVSYLLQISPWKRYSADQILQHPFMA 353
Query: 309 TYHDPDDEPDYP 320
YH+ EP P
Sbjct: 354 QYHNDQYEPLCP 365
>At1g73670 [T] KOG0660 Mitogen-activated protein kinase
Length = 576
Score = 263 bits (671), Expect = 4e-70
Identities = 152/357 (42%), Positives = 220/357 (61%), Gaps = 21/357 (5%)
Query: 7 YDIPSHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQP-FSRSMFVTRTLRELKLLKF 65
Y + YQ+ ++VG+G+YG V SAI T +VAIKKI F TR LRE+KLL+
Sbjct: 84 YGEANRYQIQEVVGKGSYGVVGSAIDTHTGERVAIKKINDVFDHISDATRILREIKLLRL 143
Query: 66 FHSHENIISVLDIVRPTSWHKFEAVYLVQELMETDLQKIIN-QQNLSEDHIQYFVYQILR 124
H +++ + I+ P S +F VY+V ELME+DL ++I +L+ +H Q+F+YQ+LR
Sbjct: 144 L-LHPDVVEIKHIMLPPSRREFRDVYVVFELMESDLHQVIKANDDLTPEHHQFFLYQLLR 202
Query: 125 ALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATR 184
LK +H+A V HRDLKP N+L N++C LK+CDFGLAR + + F T+YVATR
Sbjct: 203 GLKYVHAANVFHRDLKPKNILANADCKLKICDFGLARVSFNDAPTAI----FWTDYVATR 258
Query: 185 WYRAPEIMLSF-QEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLE 243
WYRAPE+ SF +YT A+DIWS GCI AEM++GKPLFPGK+ HQL I+ + LG+P E
Sbjct: 259 WYRAPELCGSFFSKYTPAIDIWSVGCIFAEMLLGKPLFPGKNVVHQLDIMTDFLGTPPPE 318
Query: 244 DFEQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALE 303
+I++ +A+ Y+ + K+ +P++ K +P A+ LL +++ F+P R SA EAL
Sbjct: 319 AISKIRNDKARRYLGNMRKKQPVPFSKKFPK-ADPSALRLLERLIAFDPKDRPSAEEALA 377
Query: 304 HPYLATYHDPDDEPD-YPQLNLEDNFWKIDNEARDKNEEDDIPLELLKKMLYGEVMK 359
PY EP P LE F R K +DDI ++++Y E+++
Sbjct: 378 DPYFNGLSSKVREPSTQPISKLEFEF------ERKKLTKDDI-----RELIYREILE 423
>YKL161c [T] KOG0660 Mitogen-activated protein kinase
Length = 433
Score = 260 bits (664), Expect = 3e-69
Identities = 142/312 (45%), Positives = 201/312 (63%), Gaps = 13/312 (4%)
Query: 12 HYQLVDLVGEGAYGTVCSAIHKPTN--TKVAIKKI-QPFSRSMFVTRTLRELKLLKFFHS 68
H+ L +G G++ +CS+ + +N T VAI+KI F + RTLRELKLL+
Sbjct: 22 HFHLTGKIGRGSHSLICSSTYTESNEETHVAIRKIPNAFGNKLSCKRTLRELKLLRHLRG 81
Query: 69 HENIISVLD---IVRPTSWHKFEAVYLVQELMETDLQKII-NQQNLSEDHIQYFVYQILR 124
H NI+ + D + P VYL +ELME DL +II ++Q L + H Q F+YQIL
Sbjct: 82 HPNIVWLFDTDIVFYPNG--ALNGVYLYEELMECDLSQIIRSEQRLEDAHFQSFIYQILC 139
Query: 125 ALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATR 184
ALK +HSA V+H DLKP NLL+NS+C LK+C+FGL+ S ++ + GF+ Y+ +
Sbjct: 140 ALKYIHSANVLHCDLKPKNLLVNSDCQLKICNFGLS---CSYSENHKVNDGFIKGYITSI 196
Query: 185 WYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLED 244
WY+APEI+L++QE T A+DIWS GCILAE++ KP+F GKDY L IL++LG+P E
Sbjct: 197 WYKAPEILLNYQECTKAVDIWSTGCILAELLGRKPMFEGKDYVDHLNHILQILGTPPEET 256
Query: 245 FEQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEH 304
++I S++ YI Q G + ++L NP A++LL KML F+P KRI+ +ALEH
Sbjct: 257 LQEIASQKVYNYIFQFGNIPGRSFESIL-PGANPEALELLKKMLEFDPKKRITVEDALEH 315
Query: 305 PYLATYHDPDDE 316
PYL+ +HD D+E
Sbjct: 316 PYLSMWHDIDEE 327
>At2g01450 [T] KOG0660 Mitogen-activated protein kinase
Length = 516
Score = 253 bits (647), Expect = 2e-67
Identities = 145/354 (40%), Positives = 214/354 (59%), Gaps = 21/354 (5%)
Query: 7 YDIPSHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKI-QPFSRSMFVTRTLRELKLLKF 65
Y S YQ+ ++VG+G+YG V SA T KVAIKK+ F R LRE+KLL+
Sbjct: 10 YGEASQYQIQEVVGKGSYGVVASAECPHTGGKVAIKKMTNVFEHVSDAIRILREIKLLRL 69
Query: 66 FHSHENIISVLDIVRPTSWHKFEAVYLVQELMETDLQKIIN-QQNLSEDHIQYFVYQILR 124
H +I+ + I+ P +F+ +Y+V ELME+DL ++ +L+ H Q+F+YQ+LR
Sbjct: 70 LR-HPDIVEIKHIMLPPCRKEFKDIYVVFELMESDLHHVLKVNDDLTPQHHQFFLYQLLR 128
Query: 125 ALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATR 184
LK +HSA V HRDLKP N+L N++C +K+CD GLAR + S F T+YVATR
Sbjct: 129 GLKFMHSAHVFHRDLKPKNILANADCKIKICDLGLARVSFTDSPSAV----FWTDYVATR 184
Query: 185 WYRAPEIMLSF-QEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLE 243
WYRAPE+ SF YT A+D+WS GCI AEM+ GKPLFPGK+ HQL ++ ++LG+P+
Sbjct: 185 WYRAPELCGSFYSNYTPAIDMWSVGCIFAEMLTGKPLFPGKNVVHQLELVTDLLGTPSPI 244
Query: 244 DFEQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALE 303
+I++++A++Y+ + K +P+ + ++P+A+ LL +++ F+P R SA EAL
Sbjct: 245 TLSRIRNEKARKYLGNMRRKDPVPFTHKF-PNIDPVALKLLQRLIAFDPKDRPSAEEALA 303
Query: 304 HPYLATYHDPDDEPD-YPQLNLEDNFWKIDNEARDKNEEDDIPLELLKKMLYGE 356
PY + D EP P LE F R K DD+ ++++Y E
Sbjct: 304 DPYFQGLANVDYEPSRQPISKLEFEF------ERRKLTRDDV-----RELMYRE 346
>YPR054w [T] KOG0660 Mitogen-activated protein kinase
Length = 388
Score = 251 bits (641), Expect = 1e-66
Identities = 138/317 (43%), Positives = 205/317 (64%), Gaps = 11/317 (3%)
Query: 9 IPSHYQLVDLVGEGAYGTVCSAIHKPTN--TKVAIKKIQP-FSRSMFVTRTLRELKLLKF 65
IP +Y+++ +G+GAYGTVCS K + ++A+KKI F++ + + R +RELK + F
Sbjct: 34 IPGYYEIIQFLGKGAYGTVCSVKFKGRSPAARIAVKKISNIFNKEILLKRAIRELKFMNF 93
Query: 66 FHSHENIISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQ-NLSEDHIQYFVYQILR 124
F H+NI++++D+ TS ++ +Y QEL++ DL K+I+ LSE HI+YF+YQIL
Sbjct: 94 FKGHKNIVNLIDLEIVTS-SPYDGLYCYQELIDYDLAKVIHSSVQLSEFHIKYFLYQILC 152
Query: 125 ALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCL-ASSDQSRENMVGFMTEYVAT 183
LK +HSA VIHRDLKP N+L N LK+CDFGLAR + A + + +T YVAT
Sbjct: 153 GLKYIHSADVIHRDLKPGNILCTLNGCLKICDFGLARGIHAGFFKCHSTVQPHITNYVAT 212
Query: 184 RWYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSP--- 240
RWYRAPE++LS Q Y+ ++DIW+ GCILAE KP+F G+D HQ++ I++VLG+P
Sbjct: 213 RWYRAPELLLSNQPYSKSVDIWAVGCILAEFYARKPVFMGRDSMHQIFEIIKVLGTPDKD 272
Query: 241 TLEDFEQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVE 300
L F IK+ + S P+ K IPW+N+ + AI+L+ +L ++ R++ +
Sbjct: 273 ILIKFGTIKAWNLGKN-SNNPVYKKIPWSNIF-PFASHEAINLIESLLHWDSTHRLNVEQ 330
Query: 301 ALEHPYLATYHDPDDEP 317
A+ HP+L PDDEP
Sbjct: 331 AISHPFLNEVRKPDDEP 347
>Hs20986499 [T] KOG0660 Mitogen-activated protein kinase
Length = 677
Score = 250 bits (639), Expect = 2e-66
Identities = 123/223 (55%), Positives = 161/223 (72%), Gaps = 5/223 (2%)
Query: 97 METDLQKIINQ-QNLSEDHIQYFVYQILRALKSLHSAQVIHRDLKPSNLLLNSNCDLKVC 155
ME+DL +II+ Q L+ +H++YF+YQ+LR LK +HSAQVIHRDLKPSNLL+N NC+LK+
Sbjct: 1 MESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIG 60
Query: 156 DFGLARCLASSDQSRENMVGFMTEYVATRWYRAPEIMLSFQEYTTAMDIWSCGCILAEMI 215
DFG+AR L +S + FMTEYVATRWYRAPE+MLS EYT A+D+WS GCI EM+
Sbjct: 61 DFGMARGLCTSPAEHQY---FMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEML 117
Query: 216 MGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQIKSKRAKEYISQLPMKKGIPWANVLNKE 275
+ LFPGK+Y HQL +I+ VLG+P+ + + ++R + YI LP ++ +PW V
Sbjct: 118 ARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWETVY-PG 176
Query: 276 VNPLAIDLLSKMLTFNPDKRISAVEALEHPYLATYHDPDDEPD 318
+ A+ LL +ML F P RISA AL HP+LA YHDPDDEPD
Sbjct: 177 ADRQALSLLGRMLRFEPSARISAAAALRHPFLAKYHDPDDEPD 219
>Hs20986514 [T] KOG0660 Mitogen-activated protein kinase
Length = 297
Score = 249 bits (636), Expect = 4e-66
Identities = 129/267 (48%), Positives = 177/267 (65%), Gaps = 13/267 (4%)
Query: 7 YDIPSHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKI-QPFSRSMFVTRTLRELKLLKF 65
+++P YQ + VG GAYG+VC+A T +VA+KK+ +PF + RT REL+LLK
Sbjct: 18 WEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKH 77
Query: 66 FHSHENIISVLDIVRPT-SWHKFEAVYLVQELMETDLQKIINQQNLSEDHIQYFVYQILR 124
HEN+I +LD+ P S +F VYLV LM DL I+ Q L++DH+Q+ +YQILR
Sbjct: 78 M-KHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILR 136
Query: 125 ALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATR 184
LK +HSA +IHRDLKPSNL +N +C+LK+ DFGLAR + D+ MT YVATR
Sbjct: 137 GLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR--HTDDE--------MTGYVATR 186
Query: 185 WYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLED 244
WYRAPEIML++ Y +DIWS GCI+AE++ G+ LFPG D+ QL +IL ++G+P E
Sbjct: 187 WYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAEL 246
Query: 245 FEQIKSKRAKEYISQLPMKKGIPWANV 271
++I S+ A+ YI L + +ANV
Sbjct: 247 LKKISSESARNYIQSLTQMPKMNFANV 273
>7295173 [T] KOG0664 Nemo-like MAPK-related serine/threonine protein kinase
Length = 474
Score = 239 bits (611), Expect = 4e-63
Identities = 129/301 (42%), Positives = 190/301 (62%), Gaps = 9/301 (2%)
Query: 9 IPSHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVT-RTLRELKLLKFFH 67
+P Q +G GA+G V + +VA+KK+ +S+ + R RELK+L FF
Sbjct: 36 VPQDVQPDRPIGYGAFGVVWAVTDPRDGRRVALKKLPNVFQSLVSSKRVFRELKMLCFF- 94
Query: 68 SHENIISVLDIVRPTSWHKFEAVYLVQELMETDLQKII-NQQNLSEDHIQYFVYQILRAL 126
HEN++S LDI++P F+ +Y++ EL+++DL KII + Q+LS DHI+ F+YQILR L
Sbjct: 95 KHENVLSALDILQPPHLDFFQEIYVITELLQSDLHKIIVSPQHLSADHIKVFLYQILRGL 154
Query: 127 KSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWY 186
K LHSA+++HRD+KP NLL+NSNC LK+CDFGLAR + DQ++ MT+ V T++Y
Sbjct: 155 KYLHSARILHRDIKPGNLLVNSNCVLKICDFGLAR-VEEPDQAKH-----MTQEVVTQYY 208
Query: 187 RAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFE 246
RAPEI++ + Y++A+D+WS GCI E++ + LF ++ QL +I E+LG+PT+ED
Sbjct: 209 RAPEILMGARHYSSAVDVWSVGCIFGELLGRRILFQAQNPVQQLELITELLGTPTMEDMR 268
Query: 247 QIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEHPY 306
+ + P L+ A+ LL +ML F+PDKRIS +AL HPY
Sbjct: 269 HACEGARTHMLRRAPKPPSFSVLYTLSSHATHEAVHLLCQMLVFDPDKRISVTDALAHPY 328
Query: 307 L 307
L
Sbjct: 329 L 329
>Hs7706445 [T] KOG0664 Nemo-like MAPK-related serine/threonine protein kinase
Length = 515
Score = 238 bits (607), Expect = 1e-62
Identities = 135/292 (46%), Positives = 191/292 (65%), Gaps = 11/292 (3%)
Query: 19 VGEGAYGTVCSAIHKPTNTKVAIKKI-QPFSRSMFVTRTLRELKLLKFFHSHENIISVLD 77
+G GA+G V S +VA+KK+ F + R RELK+L FF H+N++S LD
Sbjct: 132 IGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFF-KHDNVLSALD 190
Query: 78 IVRPTSWHKFEAVYLVQELMETDLQKII-NQQNLSEDHIQYFVYQILRALKSLHSAQVIH 136
I++P FE +Y+V ELM++DL KII + Q LS DH++ F+YQILR LK LHSA ++H
Sbjct: 191 ILQPPHIDYFEEIYVVTELMQSDLHKIIVSPQPLSSDHVKVFLYQILRGLKYLHSAGILH 250
Query: 137 RDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRAPEIMLSFQ 196
RD+KP NLL+NSNC LK+CDFGLAR + D+SR MT+ V T++YRAPEI++ +
Sbjct: 251 RDIKPGNLLVNSNCVLKICDFGLAR-VEELDESRH-----MTQEVVTQYYRAPEILMGSR 304
Query: 197 EYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQIKSKRAKEY 256
Y+ A+DIWS GCI AE++ + LF + QL +I ++LG+P+LE + + AK +
Sbjct: 305 HYSNAIDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAM-RTACEGAKAH 363
Query: 257 ISQLPMKK-GIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEHPYL 307
I + P K+ +P L+ + A+ LL +ML F+P KRISA +AL HPYL
Sbjct: 364 ILRGPHKQPSLPVLYTLSSQATHEAVHLLCRMLVFDPSKRISAKDALAHPYL 415
>Hs20986516 [T] KOG0660 Mitogen-activated protein kinase
Length = 307
Score = 238 bits (607), Expect = 1e-62
Identities = 122/247 (49%), Positives = 167/247 (67%), Gaps = 13/247 (5%)
Query: 7 YDIPSHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKI-QPFSRSMFVTRTLRELKLLKF 65
+++P YQ + VG GAYG+VC+A T +VA+KK+ +PF + RT REL+LLK
Sbjct: 18 WEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKH 77
Query: 66 FHSHENIISVLDIVRPT-SWHKFEAVYLVQELMETDLQKIINQQNLSEDHIQYFVYQILR 124
HEN+I +LD+ P S +F VYLV LM DL I+ Q L++DH+Q+ +YQILR
Sbjct: 78 M-KHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILR 136
Query: 125 ALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATR 184
LK +HSA +IHRDLKPSNL +N +C+LK+ DFGLAR + D+ MT YVATR
Sbjct: 137 GLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR--HTDDE--------MTGYVATR 186
Query: 185 WYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLED 244
WYRAPEIML++ Y +DIWS GCI+AE++ G+ LFPG D+ QL +IL ++G+P E
Sbjct: 187 WYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAEL 246
Query: 245 FEQIKSK 251
++I S+
Sbjct: 247 LKKISSE 253
>CE17062 [T] KOG0660 Mitogen-activated protein kinase
Length = 448
Score = 238 bits (607), Expect = 1e-62
Identities = 145/361 (40%), Positives = 197/361 (54%), Gaps = 68/361 (18%)
Query: 9 IPSHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKI-QPFSRSMFVTRTLRELKLLKFFH 67
+P Y + +GEGAYG VC+A ++PT +VAIKK +PF ++ RT RELKLL+
Sbjct: 45 LPQWYNSLKPLGEGAYGVVCTAEYEPTGDRVAIKKFFRPFQSTIHAKRTYRELKLLRTLQ 104
Query: 68 SHENIISVLDIVRPT-SWHKFEAVYLVQELMETDLQKIINQQNLSEDHIQYFVYQILRAL 126
H+N++ ++D+ P VY V LM +DLQ I+ Q L+++ IQ +YQ+LR L
Sbjct: 105 -HDNVLEMIDVFTPDPDASSLNNVYFVSVLMGSDLQNIMKIQRLTDEQIQLLIYQVLRGL 163
Query: 127 KSL-----------------------------HSAQVIHRDLKPSNLLLNSNCDLKV--- 154
K + HSA +IHRDLKPSN+ +N C++KV
Sbjct: 164 KYMSHQNFNSTIILKKLMHPFQRRNTRFRLYIHSAGIIHRDLKPSNIAVNERCEVKVFLS 223
Query: 155 --------------CDFGLARCLASSDQSRENMVGFMTEYVATRWYRAPEIMLSFQEYTT 200
DFGLAR Q E MT YVATRWYRAPEIML++ YT
Sbjct: 224 FSQLSFLILSFFKILDFGLARA-----QDAE-----MTGYVATRWYRAPEIMLNWMHYTQ 273
Query: 201 AMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQIKSKRAKEYISQL 260
+D+WS GCILAE++ G+PLFPG D+ QL I+ V+G+P E + +I+S+ A+ YI
Sbjct: 274 TVDVWSVGCILAELVSGRPLFPGDDHIDQLTKIMSVVGTPKEEFWSKIQSEEARNYI--- 330
Query: 261 PMKKGIPWAN----VLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEHPYLATYHDPDDE 316
K P L +P A++LL ML +PD+RIS AL H YL Y P+DE
Sbjct: 331 --KNRSPIIRQDFVTLFPMASPYALELLEMMLILDPDRRISVSSALRHDYLREYSVPNDE 388
Query: 317 P 317
P
Sbjct: 389 P 389
>CE02602_1 [T] KOG0660 Mitogen-activated protein kinase
Length = 342
Score = 235 bits (600), Expect = 7e-62
Identities = 131/305 (42%), Positives = 194/305 (62%), Gaps = 12/305 (3%)
Query: 11 SHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKI-QPFSRSMFVTRTLRELKLLKFFHSH 69
+ Y + +G GA+G VC AI N +VAIKKI + F LRE+++ + SH
Sbjct: 42 TQYLAQENLGAGAFGVVCRAIDSKLNKQVAIKKITRVFKNQSTAKCALREIRITREL-SH 100
Query: 70 ENIISVLDIVRPTSWHKFEAVYLVQELMETDLQKII-NQQNLSEDHIQYFVYQILRALKS 128
ENII+ D++ S + +Y+V +LMETDL ++ + Q L+E H QYF YQIL+ LK
Sbjct: 101 ENIINSTDVLMRESGSG-QDIYIVMDLMETDLLSVLKSNQTLNEKHFQYFFYQILKGLKY 159
Query: 129 LHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQS-----RENMVGFMTEYVAT 183
LHSA +IHRDLKP+NLLLN +C LK+ DFG++R S+ + ++ G +++YV+T
Sbjct: 160 LHSAGIIHRDLKPANLLLNEDCSLKIADFGMSRSGPSTKTTPNTSPNAHISGDLSQYVST 219
Query: 184 RWYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLE 243
WYRAPEI+LS EY T +DIWS GCILAEM++ +P+F G D + Q+ +++E LG+P +
Sbjct: 220 LWYRAPEILLSMGEYDTQVDIWSAGCILAEMLLLRPIFTGTDSYSQIQLLIEYLGTPDEQ 279
Query: 244 DFEQIKSKRAKEYISQLPMKKGIPWANVL-NKEVNPLAIDLLSKMLTFNPDKRISAVEAL 302
+IKS ++YIS K +P+ + N + A +++SKML +P KR SA + L
Sbjct: 280 VIRRIKSPSIRDYISSFGPKTPLPFTAMFPNASIE--ARNIVSKMLQISPWKRFSAEQLL 337
Query: 303 EHPYL 307
E P++
Sbjct: 338 EEPFV 342
>Hs21237745 [T] KOG0665 Jun-N-terminal kinase (JNK)
Length = 424
Score = 234 bits (597), Expect = 1e-61
Identities = 143/366 (39%), Positives = 211/366 (57%), Gaps = 36/366 (9%)
Query: 6 TYDIPSHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKI-QPFSRSMFVTRTLRELKLLK 64
T+ + YQ + +G GA G VC+A VA+KK+ +PF R REL LLK
Sbjct: 19 TFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLK 78
Query: 65 FFHSHENIISVLDIVRPT-SWHKFEAVYLVQELMETDLQKIINQQNLSEDHIQYFVYQIL 123
+ H+NIIS+L++ P + +F+ VYLV ELM+ +L ++I+ + L + + Y +YQ+L
Sbjct: 79 CVN-HKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHME-LDHERMSYLLYQML 136
Query: 124 RALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVAT 183
+K LHSA +IHRDLKPSN+++ S+C LK+ DFGLAR ++ MT YV T
Sbjct: 137 CGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTN--------FMMTPYVVT 188
Query: 184 RWYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLE 243
R+YRAPE++L Y +DIWS GCI+AEM++ K LFPG+DY Q ++E LG+P+ E
Sbjct: 189 RYYRAPEVILG-MGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPSAE 247
Query: 244 DFEQIKSKRAKEYISQLPMKKGIPWANVLNKEVNP-----------LAIDLLSKMLTFNP 292
++++ + Y+ P GI + + + P A DLLSKML +P
Sbjct: 248 FMKKLQ-PTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDP 306
Query: 293 DKRISAVEALEHPYLATYHDPDDEPDYPQLNLEDNFWKIDNEARDKNEEDDIPLELLKKM 352
DKRIS EAL HPY+ ++DP E + P + D + EE + +E K++
Sbjct: 307 DKRISVDEALRHPYITVWYDP-AEAEAPPPQIYD----------AQLEEREHAIEEWKEL 355
Query: 353 LYGEVM 358
+Y EVM
Sbjct: 356 IYKEVM 361
>Hs21237742 [T] KOG0665 Jun-N-terminal kinase (JNK)
Length = 382
Score = 234 bits (597), Expect = 1e-61
Identities = 143/366 (39%), Positives = 211/366 (57%), Gaps = 36/366 (9%)
Query: 6 TYDIPSHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKI-QPFSRSMFVTRTLRELKLLK 64
T+ + YQ + +G GA G VC+A VA+KK+ +PF R REL LLK
Sbjct: 19 TFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLK 78
Query: 65 FFHSHENIISVLDIVRPT-SWHKFEAVYLVQELMETDLQKIINQQNLSEDHIQYFVYQIL 123
+ H+NIIS+L++ P + +F+ VYLV ELM+ +L ++I+ + L + + Y +YQ+L
Sbjct: 79 CVN-HKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHME-LDHERMSYLLYQML 136
Query: 124 RALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVAT 183
+K LHSA +IHRDLKPSN+++ S+C LK+ DFGLAR ++ MT YV T
Sbjct: 137 CGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTN--------FMMTPYVVT 188
Query: 184 RWYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLE 243
R+YRAPE++L Y +DIWS GCI+AEM++ K LFPG+DY Q ++E LG+P+ E
Sbjct: 189 RYYRAPEVILG-MGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPSAE 247
Query: 244 DFEQIKSKRAKEYISQLPMKKGIPWANVLNKEVNP-----------LAIDLLSKMLTFNP 292
++++ + Y+ P GI + + + P A DLLSKML +P
Sbjct: 248 FMKKLQ-PTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDP 306
Query: 293 DKRISAVEALEHPYLATYHDPDDEPDYPQLNLEDNFWKIDNEARDKNEEDDIPLELLKKM 352
DKRIS EAL HPY+ ++DP E + P + D + EE + +E K++
Sbjct: 307 DKRISVDEALRHPYITVWYDP-AEAEAPPPQIYD----------AQLEEREHAIEEWKEL 355
Query: 353 LYGEVM 358
+Y EVM
Sbjct: 356 IYKEVM 361
>CE29020 [T] KOG0660 Mitogen-activated protein kinase
Length = 470
Score = 231 bits (589), Expect = 1e-60
Identities = 129/340 (37%), Positives = 201/340 (58%), Gaps = 22/340 (6%)
Query: 5 ITYDIPSH----YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKI-QPFSRSMFVTRTLRE 59
+T D+ +H + L +G+GAYG V A K + VA+KKI F RT RE
Sbjct: 1 MTDDVDTHIHEKFDLQKRLGKGAYGIVWKAYDKRSRETVALKKIFDAFRNPTDSQRTFRE 60
Query: 60 LKLLKFFHSHENIISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQNLSED-HIQYF 118
+ L+ F H N+I + +I R + +YL E ME DL +I + ++ +D H QY
Sbjct: 61 VMFLQEFGKHPNVIKLYNIFRADNDRD---IYLAFEFMEADLHNVIKKGSILKDVHKQYI 117
Query: 119 VYQILRALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENM-VGFM 177
+ Q+ RA++ LHS V+HRDLKPSN+LL+++C +K+ DFGLAR L+S + E + +
Sbjct: 118 MCQLFRAIRFLHSGNVLHRDLKPSNVLLDADCRVKLADFGLARSLSSLEDYPEGQKMPDL 177
Query: 178 TEYVATRWYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVL 237
TEYVATRWYR+PEI+L+ + YT +D+WS GCILAEM++G+ LFPG +Q+ I+ +
Sbjct: 178 TEYVATRWYRSPEILLAAKRYTKGVDMWSLGCILAEMLIGRALFPGSSTINQIERIMNTI 237
Query: 238 GSPTLEDFEQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRIS 297
P+ D I S A + ++P + P +++ + AID++ ++L F P KR++
Sbjct: 238 AKPSRADIASIGSHYAASVLEKMPQRPRKP-LDLIITQSQTAAIDMVQRLLIFAPQKRLT 296
Query: 298 AVEALEHPYLATYHDPDDE-----------PDYPQLNLED 326
+ L HPY+ +H+P +E PD+ QL+++D
Sbjct: 297 VEQCLVHPYVVQFHNPSEEPVLNYEVYPPLPDHIQLSIDD 336
>Hs4506081 [T] KOG0665 Jun-N-terminal kinase (JNK)
Length = 422
Score = 226 bits (575), Expect = 5e-59
Identities = 141/366 (38%), Positives = 208/366 (56%), Gaps = 36/366 (9%)
Query: 6 TYDIPSHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKI-QPFSRSMFVTRTLRELKLLK 64
T+ + YQ + +G GA G VC+A + VAIKK+ +PF R REL L+K
Sbjct: 57 TFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMK 116
Query: 65 FFHSHENIISVLDIVRPT-SWHKFEAVYLVQELMETDLQKIINQQNLSEDHIQYFVYQIL 123
+ H+NIIS+L++ P + +F+ VYLV ELM+ +L ++I Q L + + Y +YQ+L
Sbjct: 117 CVN-HKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI-QMELDHERMSYLLYQML 174
Query: 124 RALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVAT 183
+K LHSA +IHRDLKPSN+++ S+C LK+ DFGLAR +S MT YV T
Sbjct: 175 CGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTS--------FMMTPYVVT 226
Query: 184 RWYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLE 243
R+YRAPE++L Y +DIWS GCI+ EM+ K LFPG+DY Q ++E LG+P E
Sbjct: 227 RYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPE 285
Query: 244 DFEQIKSKRAKEYISQLPMKKGIPWANVL-----------NKEVNPLAIDLLSKMLTFNP 292
++++ + Y+ P G+ + + NK A DLLSKML +P
Sbjct: 286 FMKKLQ-PTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDP 344
Query: 293 DKRISAVEALEHPYLATYHDPDDEPDYPQLNLEDNFWKIDNEARDKNEEDDIPLELLKKM 352
KRIS +AL+HPY+ ++DP E + P + D + +E + +E K++
Sbjct: 345 AKRISVDDALQHPYINVWYDP-AEVEAPPPQIYDK----------QLDEREHTIEEWKEL 393
Query: 353 LYGEVM 358
+Y EVM
Sbjct: 394 IYKEVM 399
>Hs20986510 [T] KOG0665 Jun-N-terminal kinase (JNK)
Length = 464
Score = 226 bits (575), Expect = 5e-59
Identities = 141/366 (38%), Positives = 208/366 (56%), Gaps = 36/366 (9%)
Query: 6 TYDIPSHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKI-QPFSRSMFVTRTLRELKLLK 64
T+ + YQ + +G GA G VC+A + VAIKK+ +PF R REL L+K
Sbjct: 57 TFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMK 116
Query: 65 FFHSHENIISVLDIVRPT-SWHKFEAVYLVQELMETDLQKIINQQNLSEDHIQYFVYQIL 123
+ H+NIIS+L++ P + +F+ VYLV ELM+ +L ++I Q L + + Y +YQ+L
Sbjct: 117 CVN-HKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI-QMELDHERMSYLLYQML 174
Query: 124 RALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVAT 183
+K LHSA +IHRDLKPSN+++ S+C LK+ DFGLAR +S MT YV T
Sbjct: 175 CGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTS--------FMMTPYVVT 226
Query: 184 RWYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLE 243
R+YRAPE++L Y +DIWS GCI+ EM+ K LFPG+DY Q ++E LG+P E
Sbjct: 227 RYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPE 285
Query: 244 DFEQIKSKRAKEYISQLPMKKGIPWANVL-----------NKEVNPLAIDLLSKMLTFNP 292
++++ + Y+ P G+ + + NK A DLLSKML +P
Sbjct: 286 FMKKLQ-PTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDP 344
Query: 293 DKRISAVEALEHPYLATYHDPDDEPDYPQLNLEDNFWKIDNEARDKNEEDDIPLELLKKM 352
KRIS +AL+HPY+ ++DP E + P + D + +E + +E K++
Sbjct: 345 AKRISVDDALQHPYINVWYDP-AEVEAPPPQIYDK----------QLDEREHTIEEWKEL 393
Query: 353 LYGEVM 358
+Y EVM
Sbjct: 394 IYKEVM 399
>Hs20986506 [T] KOG0665 Jun-N-terminal kinase (JNK)
Length = 426
Score = 226 bits (575), Expect = 5e-59
Identities = 141/366 (38%), Positives = 208/366 (56%), Gaps = 36/366 (9%)
Query: 6 TYDIPSHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKI-QPFSRSMFVTRTLRELKLLK 64
T+ + YQ + +G GA G VC+A + VAIKK+ +PF R REL L+K
Sbjct: 19 TFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMK 78
Query: 65 FFHSHENIISVLDIVRPT-SWHKFEAVYLVQELMETDLQKIINQQNLSEDHIQYFVYQIL 123
+ H+NIIS+L++ P + +F+ VYLV ELM+ +L ++I Q L + + Y +YQ+L
Sbjct: 79 CVN-HKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVI-QMELDHERMSYLLYQML 136
Query: 124 RALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVAT 183
+K LHSA +IHRDLKPSN+++ S+C LK+ DFGLAR +S MT YV T
Sbjct: 137 CGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTS--------FMMTPYVVT 188
Query: 184 RWYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLE 243
R+YRAPE++L Y +DIWS GCI+ EM+ K LFPG+DY Q ++E LG+P E
Sbjct: 189 RYYRAPEVILG-MGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPE 247
Query: 244 DFEQIKSKRAKEYISQLPMKKGIPWANVL-----------NKEVNPLAIDLLSKMLTFNP 292
++++ + Y+ P G+ + + NK A DLLSKML +P
Sbjct: 248 FMKKLQ-PTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDP 306
Query: 293 DKRISAVEALEHPYLATYHDPDDEPDYPQLNLEDNFWKIDNEARDKNEEDDIPLELLKKM 352
KRIS +AL+HPY+ ++DP E + P + D + +E + +E K++
Sbjct: 307 AKRISVDDALQHPYINVWYDP-AEVEAPPPQIYDK----------QLDEREHTIEEWKEL 355
Query: 353 LYGEVM 358
+Y EVM
Sbjct: 356 IYKEVM 361
>CE29478 [T] KOG0664 Nemo-like MAPK-related serine/threonine protein kinase
Length = 437
Score = 224 bits (571), Expect = 2e-58
Identities = 128/296 (43%), Positives = 187/296 (62%), Gaps = 17/296 (5%)
Query: 19 VGEGAYGTVCSAIHKPTNTKVAIKKI-QPFSRSMFVTRTLRELKLLKFFHSHENIISVLD 77
+G GA+G V S + +VA+KK+ F R RE+K+L F H+N++S+LD
Sbjct: 49 IGYGAFGVVWSVTDPRSGKRVALKKMPNVFQNLASCKRVFREIKMLSSFR-HDNVLSLLD 107
Query: 78 IVRPTSWHKFEAVYLVQELMETDLQKII-NQQNLSEDHIQYFVYQILRALKSLHSAQVIH 136
I++P + F+ +Y++ ELM++DL KII + Q L+ DH++ FVYQILR LK LH+A ++H
Sbjct: 108 ILQPANPSFFQELYVLTELMQSDLHKIIVSPQALTPDHVKVFVYQILRGLKYLHTANILH 167
Query: 137 RDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRAPEIMLSFQ 196
RD+KP NLL+NSNC LK+CDFGLAR D+ MT V T++YRAPE+++ +
Sbjct: 168 RDIKPGNLLVNSNCILKICDFGLARTWDQRDRLN------MTHEVVTQYYRAPELLMGAR 221
Query: 197 EYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQIKSKRAKEY 256
YT A+DIWS GCI AE++ K LF QL +I+++LG+P+ E + + AK +
Sbjct: 222 RYTGAVDIWSVGCIFAELLQRKILFQAAGPIEQLQMIIDLLGTPSQEAM-KYACEGAKNH 280
Query: 257 ISQLPMKKGIPWANVLNKEVNP-----LAIDLLSKMLTFNPDKRISAVEALEHPYL 307
+ + ++ P L K +P A+DLL K+L F+PDKRIS EAL+H YL
Sbjct: 281 VLRAGLR--APDTQRLYKIASPDDKNHEAVDLLQKLLHFDPDKRISVEEALQHRYL 334
>CE29477 [T] KOG0664 Nemo-like MAPK-related serine/threonine protein kinase
Length = 462
Score = 224 bits (571), Expect = 2e-58
Identities = 128/296 (43%), Positives = 187/296 (62%), Gaps = 17/296 (5%)
Query: 19 VGEGAYGTVCSAIHKPTNTKVAIKKI-QPFSRSMFVTRTLRELKLLKFFHSHENIISVLD 77
+G GA+G V S + +VA+KK+ F R RE+K+L F H+N++S+LD
Sbjct: 74 IGYGAFGVVWSVTDPRSGKRVALKKMPNVFQNLASCKRVFREIKMLSSFR-HDNVLSLLD 132
Query: 78 IVRPTSWHKFEAVYLVQELMETDLQKII-NQQNLSEDHIQYFVYQILRALKSLHSAQVIH 136
I++P + F+ +Y++ ELM++DL KII + Q L+ DH++ FVYQILR LK LH+A ++H
Sbjct: 133 ILQPANPSFFQELYVLTELMQSDLHKIIVSPQALTPDHVKVFVYQILRGLKYLHTANILH 192
Query: 137 RDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRAPEIMLSFQ 196
RD+KP NLL+NSNC LK+CDFGLAR D+ MT V T++YRAPE+++ +
Sbjct: 193 RDIKPGNLLVNSNCILKICDFGLARTWDQRDRLN------MTHEVVTQYYRAPELLMGAR 246
Query: 197 EYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQIKSKRAKEY 256
YT A+DIWS GCI AE++ K LF QL +I+++LG+P+ E + + AK +
Sbjct: 247 RYTGAVDIWSVGCIFAELLQRKILFQAAGPIEQLQMIIDLLGTPSQEAM-KYACEGAKNH 305
Query: 257 ISQLPMKKGIPWANVLNKEVNP-----LAIDLLSKMLTFNPDKRISAVEALEHPYL 307
+ + ++ P L K +P A+DLL K+L F+PDKRIS EAL+H YL
Sbjct: 306 VLRAGLR--APDTQRLYKIASPDDKNHEAVDLLQKLLHFDPDKRISVEEALQHRYL 359
>CE29476 [T] KOG0664 Nemo-like MAPK-related serine/threonine protein kinase
Length = 634
Score = 224 bits (571), Expect = 2e-58
Identities = 128/296 (43%), Positives = 187/296 (62%), Gaps = 17/296 (5%)
Query: 19 VGEGAYGTVCSAIHKPTNTKVAIKKI-QPFSRSMFVTRTLRELKLLKFFHSHENIISVLD 77
+G GA+G V S + +VA+KK+ F R RE+K+L F H+N++S+LD
Sbjct: 246 IGYGAFGVVWSVTDPRSGKRVALKKMPNVFQNLASCKRVFREIKMLSSFR-HDNVLSLLD 304
Query: 78 IVRPTSWHKFEAVYLVQELMETDLQKII-NQQNLSEDHIQYFVYQILRALKSLHSAQVIH 136
I++P + F+ +Y++ ELM++DL KII + Q L+ DH++ FVYQILR LK LH+A ++H
Sbjct: 305 ILQPANPSFFQELYVLTELMQSDLHKIIVSPQALTPDHVKVFVYQILRGLKYLHTANILH 364
Query: 137 RDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRAPEIMLSFQ 196
RD+KP NLL+NSNC LK+CDFGLAR D+ MT V T++YRAPE+++ +
Sbjct: 365 RDIKPGNLLVNSNCILKICDFGLARTWDQRDRLN------MTHEVVTQYYRAPELLMGAR 418
Query: 197 EYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQIKSKRAKEY 256
YT A+DIWS GCI AE++ K LF QL +I+++LG+P+ E + + AK +
Sbjct: 419 RYTGAVDIWSVGCIFAELLQRKILFQAAGPIEQLQMIIDLLGTPSQEAM-KYACEGAKNH 477
Query: 257 ISQLPMKKGIPWANVLNKEVNP-----LAIDLLSKMLTFNPDKRISAVEALEHPYL 307
+ + ++ P L K +P A+DLL K+L F+PDKRIS EAL+H YL
Sbjct: 478 VLRAGLR--APDTQRLYKIASPDDKNHEAVDLLQKLLHFDPDKRISVEEALQHRYL 531
>HsM20070143 [T] KOG0665 Jun-N-terminal kinase (JNK)
Length = 424
Score = 223 bits (569), Expect = 3e-58
Identities = 138/366 (37%), Positives = 207/366 (55%), Gaps = 36/366 (9%)
Query: 6 TYDIPSHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKI-QPFSRSMFVTRTLRELKLLK 64
T+ + YQ + +G GA G VC+A VA+KK+ +PF R REL LLK
Sbjct: 19 TFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLK 78
Query: 65 FFHSHENIISVLDIVRPT-SWHKFEAVYLVQELMETDLQKIINQQNLSEDHIQYFVYQIL 123
+ H+NIIS+L++ P + +F+ VYLV ELM+ +L ++I+ + L + + Y +YQ+L
Sbjct: 79 CVN-HKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHME-LDHERMSYLLYQML 136
Query: 124 RALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVAT 183
+K LHSA +IHRDLKPSN+++ S+C LK+ DFGLAR ++ MT YV T
Sbjct: 137 CGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTN--------FMMTPYVVT 188
Query: 184 RWYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLE 243
R+YRAPE++L Y +DIWS GCI+ E++ G +F G D+ Q ++E LG+P+ E
Sbjct: 189 RYYRAPEVILG-MGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAE 247
Query: 244 DFEQIKSKRAKEYISQLPMKKGIPWANVLNKEVNP-----------LAIDLLSKMLTFNP 292
++++ + Y+ P GI + + + P A DLLSKML +P
Sbjct: 248 FMKKLQ-PTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDP 306
Query: 293 DKRISAVEALEHPYLATYHDPDDEPDYPQLNLEDNFWKIDNEARDKNEEDDIPLELLKKM 352
DKRIS EAL HPY+ ++DP E + P + D + EE + +E K++
Sbjct: 307 DKRISVDEALRHPYITVWYDP-AEAEAPPPQIYD----------AQLEEREHAIEEWKEL 355
Query: 353 LYGEVM 358
+Y EVM
Sbjct: 356 IYKEVM 361
>Hs4506095 [T] KOG0665 Jun-N-terminal kinase (JNK)
Length = 384
Score = 223 bits (569), Expect = 3e-58
Identities = 140/366 (38%), Positives = 204/366 (55%), Gaps = 36/366 (9%)
Query: 6 TYDIPSHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKI-QPFSRSMFVTRTLRELKLLK 64
T+ + YQ + +G GA G VC+A VAIKK+ +PF R REL L+K
Sbjct: 19 TFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMK 78
Query: 65 FFHSHENIISVLDIVRPT-SWHKFEAVYLVQELMETDLQKIINQQNLSEDHIQYFVYQIL 123
+ H+NII +L++ P S +F+ VY+V ELM+ +L ++I Q L + + Y +YQ+L
Sbjct: 79 CVN-HKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVI-QMELDHERMSYLLYQML 136
Query: 124 RALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVAT 183
+K LHSA +IHRDLKPSN+++ S+C LK+ DFGLAR +S MT YV T
Sbjct: 137 CGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTS--------FMMTPYVVT 188
Query: 184 RWYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLE 243
R+YRAPE++L Y +D+WS GCI+ EM+ K LFPG+DY Q ++E LG+P E
Sbjct: 189 RYYRAPEVILG-MGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPE 247
Query: 244 DFEQIKSKRAKEYISQLPMKKGIPWANVL-----------NKEVNPLAIDLLSKMLTFNP 292
++++ + Y+ P G + + NK A DLLSKML +
Sbjct: 248 FMKKLQ-PTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDA 306
Query: 293 DKRISAVEALEHPYLATYHDPDDEPDYPQLNLEDNFWKIDNEARDKNEEDDIPLELLKKM 352
KRIS EAL+HPY+ ++DP + P KI ++ D+ E +E K++
Sbjct: 307 SKRISVDEALQHPYINVWYDPSEAEAPPP--------KIPDKQLDEREH---TIEEWKEL 355
Query: 353 LYGEVM 358
+Y EVM
Sbjct: 356 IYKEVM 361
>Hs21237739 [T] KOG0665 Jun-N-terminal kinase (JNK)
Length = 382
Score = 223 bits (569), Expect = 3e-58
Identities = 138/366 (37%), Positives = 207/366 (55%), Gaps = 36/366 (9%)
Query: 6 TYDIPSHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKI-QPFSRSMFVTRTLRELKLLK 64
T+ + YQ + +G GA G VC+A VA+KK+ +PF R REL LLK
Sbjct: 19 TFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLK 78
Query: 65 FFHSHENIISVLDIVRPT-SWHKFEAVYLVQELMETDLQKIINQQNLSEDHIQYFVYQIL 123
+ H+NIIS+L++ P + +F+ VYLV ELM+ +L ++I+ + L + + Y +YQ+L
Sbjct: 79 CVN-HKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHME-LDHERMSYLLYQML 136
Query: 124 RALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVAT 183
+K LHSA +IHRDLKPSN+++ S+C LK+ DFGLAR ++ MT YV T
Sbjct: 137 CGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTN--------FMMTPYVVT 188
Query: 184 RWYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLE 243
R+YRAPE++L Y +DIWS GCI+ E++ G +F G D+ Q ++E LG+P+ E
Sbjct: 189 RYYRAPEVILG-MGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAE 247
Query: 244 DFEQIKSKRAKEYISQLPMKKGIPWANVLNKEVNP-----------LAIDLLSKMLTFNP 292
++++ + Y+ P GI + + + P A DLLSKML +P
Sbjct: 248 FMKKLQ-PTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDP 306
Query: 293 DKRISAVEALEHPYLATYHDPDDEPDYPQLNLEDNFWKIDNEARDKNEEDDIPLELLKKM 352
DKRIS EAL HPY+ ++DP E + P + D + EE + +E K++
Sbjct: 307 DKRISVDEALRHPYITVWYDP-AEAEAPPPQIYD----------AQLEEREHAIEEWKEL 355
Query: 353 LYGEVM 358
+Y EVM
Sbjct: 356 IYKEVM 361
>Hs21237736 [T] KOG0665 Jun-N-terminal kinase (JNK)
Length = 424
Score = 223 bits (569), Expect = 3e-58
Identities = 138/366 (37%), Positives = 207/366 (55%), Gaps = 36/366 (9%)
Query: 6 TYDIPSHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKI-QPFSRSMFVTRTLRELKLLK 64
T+ + YQ + +G GA G VC+A VA+KK+ +PF R REL LLK
Sbjct: 19 TFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLK 78
Query: 65 FFHSHENIISVLDIVRPT-SWHKFEAVYLVQELMETDLQKIINQQNLSEDHIQYFVYQIL 123
+ H+NIIS+L++ P + +F+ VYLV ELM+ +L ++I+ + L + + Y +YQ+L
Sbjct: 79 CVN-HKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHME-LDHERMSYLLYQML 136
Query: 124 RALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVAT 183
+K LHSA +IHRDLKPSN+++ S+C LK+ DFGLAR ++ MT YV T
Sbjct: 137 CGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTN--------FMMTPYVVT 188
Query: 184 RWYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLE 243
R+YRAPE++L Y +DIWS GCI+ E++ G +F G D+ Q ++E LG+P+ E
Sbjct: 189 RYYRAPEVILG-MGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAE 247
Query: 244 DFEQIKSKRAKEYISQLPMKKGIPWANVLNKEVNP-----------LAIDLLSKMLTFNP 292
++++ + Y+ P GI + + + P A DLLSKML +P
Sbjct: 248 FMKKLQ-PTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDP 306
Query: 293 DKRISAVEALEHPYLATYHDPDDEPDYPQLNLEDNFWKIDNEARDKNEEDDIPLELLKKM 352
DKRIS EAL HPY+ ++DP E + P + D + EE + +E K++
Sbjct: 307 DKRISVDEALRHPYITVWYDP-AEAEAPPPQIYD----------AQLEEREHAIEEWKEL 355
Query: 353 LYGEVM 358
+Y EVM
Sbjct: 356 IYKEVM 361
>Hs20986523 [T] KOG0665 Jun-N-terminal kinase (JNK)
Length = 427
Score = 223 bits (569), Expect = 3e-58
Identities = 140/366 (38%), Positives = 204/366 (55%), Gaps = 36/366 (9%)
Query: 6 TYDIPSHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKI-QPFSRSMFVTRTLRELKLLK 64
T+ + YQ + +G GA G VC+A VAIKK+ +PF R REL L+K
Sbjct: 19 TFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMK 78
Query: 65 FFHSHENIISVLDIVRPT-SWHKFEAVYLVQELMETDLQKIINQQNLSEDHIQYFVYQIL 123
+ H+NII +L++ P S +F+ VY+V ELM+ +L ++I Q L + + Y +YQ+L
Sbjct: 79 CVN-HKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVI-QMELDHERMSYLLYQML 136
Query: 124 RALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVAT 183
+K LHSA +IHRDLKPSN+++ S+C LK+ DFGLAR +S MT YV T
Sbjct: 137 CGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTS--------FMMTPYVVT 188
Query: 184 RWYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLE 243
R+YRAPE++L Y +D+WS GCI+ EM+ K LFPG+DY Q ++E LG+P E
Sbjct: 189 RYYRAPEVILG-MGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPE 247
Query: 244 DFEQIKSKRAKEYISQLPMKKGIPWANVL-----------NKEVNPLAIDLLSKMLTFNP 292
++++ + Y+ P G + + NK A DLLSKML +
Sbjct: 248 FMKKLQ-PTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDA 306
Query: 293 DKRISAVEALEHPYLATYHDPDDEPDYPQLNLEDNFWKIDNEARDKNEEDDIPLELLKKM 352
KRIS EAL+HPY+ ++DP + P KI ++ D+ E +E K++
Sbjct: 307 SKRISVDEALQHPYINVWYDPSEAEAPPP--------KIPDKQLDEREH---TIEEWKEL 355
Query: 353 LYGEVM 358
+Y EVM
Sbjct: 356 IYKEVM 361
>Hs20986521 [T] KOG0665 Jun-N-terminal kinase (JNK)
Length = 427
Score = 222 bits (566), Expect = 6e-58
Identities = 141/366 (38%), Positives = 203/366 (54%), Gaps = 36/366 (9%)
Query: 6 TYDIPSHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKI-QPFSRSMFVTRTLRELKLLK 64
T+ + YQ + +G GA G VC+A VAIKK+ +PF R REL L+K
Sbjct: 19 TFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMK 78
Query: 65 FFHSHENIISVLDIVRPT-SWHKFEAVYLVQELMETDLQKIINQQNLSEDHIQYFVYQIL 123
+ H+NII +L++ P S +F+ VY+V ELM+ +L ++I Q L + + Y +YQ+L
Sbjct: 79 CVN-HKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVI-QMELDHERMSYLLYQML 136
Query: 124 RALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVAT 183
+K LHSA +IHRDLKPSN+++ S+C LK+ DFGLAR +S MT YV T
Sbjct: 137 CGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTS--------FMMTPYVVT 188
Query: 184 RWYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLE 243
R+YRAPE++L Y +DIWS GCI+ EMI G LFPG D+ Q ++E LG+P E
Sbjct: 189 RYYRAPEVILG-MGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPE 247
Query: 244 DFEQIKSKRAKEYISQLPMKKGIPWANVL-----------NKEVNPLAIDLLSKMLTFNP 292
++++ + Y+ P G + + NK A DLLSKML +
Sbjct: 248 FMKKLQ-PTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDA 306
Query: 293 DKRISAVEALEHPYLATYHDPDDEPDYPQLNLEDNFWKIDNEARDKNEEDDIPLELLKKM 352
KRIS EAL+HPY+ ++DP + P KI ++ D+ E +E K++
Sbjct: 307 SKRISVDEALQHPYINVWYDPSEAEAPPP--------KIPDKQLDEREH---TIEEWKEL 355
Query: 353 LYGEVM 358
+Y EVM
Sbjct: 356 IYKEVM 361
>Hs20986519 [T] KOG0665 Jun-N-terminal kinase (JNK)
Length = 384
Score = 222 bits (566), Expect = 6e-58
Identities = 141/366 (38%), Positives = 203/366 (54%), Gaps = 36/366 (9%)
Query: 6 TYDIPSHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKI-QPFSRSMFVTRTLRELKLLK 64
T+ + YQ + +G GA G VC+A VAIKK+ +PF R REL L+K
Sbjct: 19 TFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMK 78
Query: 65 FFHSHENIISVLDIVRPT-SWHKFEAVYLVQELMETDLQKIINQQNLSEDHIQYFVYQIL 123
+ H+NII +L++ P S +F+ VY+V ELM+ +L ++I Q L + + Y +YQ+L
Sbjct: 79 CVN-HKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVI-QMELDHERMSYLLYQML 136
Query: 124 RALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVAT 183
+K LHSA +IHRDLKPSN+++ S+C LK+ DFGLAR +S MT YV T
Sbjct: 137 CGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTS--------FMMTPYVVT 188
Query: 184 RWYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLE 243
R+YRAPE++L Y +DIWS GCI+ EMI G LFPG D+ Q ++E LG+P E
Sbjct: 189 RYYRAPEVILG-MGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPE 247
Query: 244 DFEQIKSKRAKEYISQLPMKKGIPWANVL-----------NKEVNPLAIDLLSKMLTFNP 292
++++ + Y+ P G + + NK A DLLSKML +
Sbjct: 248 FMKKLQ-PTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDA 306
Query: 293 DKRISAVEALEHPYLATYHDPDDEPDYPQLNLEDNFWKIDNEARDKNEEDDIPLELLKKM 352
KRIS EAL+HPY+ ++DP + P KI ++ D+ E +E K++
Sbjct: 307 SKRISVDEALQHPYINVWYDPSEAEAPPP--------KIPDKQLDEREH---TIEEWKEL 355
Query: 353 LYGEVM 358
+Y EVM
Sbjct: 356 IYKEVM 361
>CE29318 [T] KOG0660 Mitogen-activated protein kinase
Length = 474
Score = 222 bits (565), Expect = 8e-58
Identities = 143/358 (39%), Positives = 201/358 (55%), Gaps = 30/358 (8%)
Query: 1 MPRTITYDIPSHYQL----VDLVGEGAYGTVC--SAIHKPTNTK-VAIKKI-QPFSRSMF 52
M R IT+ IP Y + ++ +G G++G V SA+ + + VAIKK+ +PF
Sbjct: 102 MIRNITFAIPEGYDVEPNSIEYLGGGSFGNVIKTSAVCRDGLRRYVAIKKMREPFFDPHH 161
Query: 53 VTRTLRELKLLKFFHSHENIISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQN--- 109
R RE KLL+ H+NII LDI P + F VY+V E L +I+ QQ
Sbjct: 162 ARRIFRETKLLQLMR-HDNIICALDIYTPDEENDFRDVYVVTEFAGRSLYQILKQQRDYG 220
Query: 110 ---LSEDHIQYFVYQILRALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASS 166
L+++HI++ +YQI+RALK +HSA +IHRDLKP NL L + DL + DFGLAR L
Sbjct: 221 RRVLTDEHIKFIIYQIIRALKYIHSANIIHRDLKPGNLALTDDSDLMILDFGLARSLEKK 280
Query: 167 DQSRENMVGFMTEYVATRWYRAPEIML-SFQEYTTAMDIWSCGCILAEMIMGKPLFPGKD 225
D S +T+YV TRWYR+PE++ YT D+WS GCI AE++ G+PLFPG +
Sbjct: 281 DTS-------LTQYVQTRWYRSPEVIYWKIDSYTNLADMWSLGCIAAELLTGEPLFPGDE 333
Query: 226 YHHQLWIILEVLGSP---TLEDFEQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLA-- 280
+ Q I ++ GSP L E S K I K + +V + NP
Sbjct: 334 PNAQYQRITQLCGSPDEELLTKIENDNSSAIKAVIQSYTTHKRRNFRDVFSAH-NPSEDF 392
Query: 281 IDLLSKMLTFNPDKRISAVEALEHPYLATYHDPDDEPDYPQL-NLEDNFWKIDNEARD 337
IDLL K+L +P+KRI+ EA++HPYLA + P+DEP + +L+D+ + E RD
Sbjct: 393 IDLLEKLLVLDPEKRITVEEAIQHPYLAEFSLPEDEPRADHIFDLDDSQARTRFEWRD 450
>Hs4506089 [T] KOG0660 Mitogen-activated protein kinase
Length = 557
Score = 217 bits (553), Expect = 2e-56
Identities = 126/322 (39%), Positives = 194/322 (60%), Gaps = 24/322 (7%)
Query: 7 YDIPSHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTLRELKLLKFF 66
YD+ + +G G G V SA+ KVA+KKI S + + LRE+K+++
Sbjct: 14 YDLGGRFVDFQPLGFGVNGLVLSAVDSRACRKVAVKKIA-LSDARSMKHALREIKIIRRL 72
Query: 67 HSHENIISVLDIVRPTSWH------KFEAVYLVQELMETDLQKIINQQNLSEDHIQYFVY 120
H+NI+ V +++ P KF Y+VQE METDL +++ Q L+E+H + F+Y
Sbjct: 73 -DHDNIVKVYEVLGPKGTDLQGELFKFSVAYIVQEYMETDLARLLEQGTLAEEHAKLFMY 131
Query: 121 QILRALKSLHSAQVIHRDLKPSNLLLNS-NCDLKVCDFGLARCLASSDQSRENMVGFMTE 179
Q+LR LK +HSA V+HRDLKP+N+ +++ + LK+ DFGLAR + DQ + G+++E
Sbjct: 132 QLLRGLKYIHSANVLHRDLKPANIFISTEDLVLKIGDFGLARIV---DQHYSHK-GYLSE 187
Query: 180 YVATRWYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGS 239
+ T+WYR+P ++LS YT A+D+W+ GCILAEM+ G+ LF G Q+ +ILE +
Sbjct: 188 GLVTKWYRSPRLLLSPNNYTKAIDMWAAGCILAEMLTGRMLFAGAHELEQMQLILETIPV 247
Query: 240 PTLEDFEQI----KSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKR 295
ED +++ S + + + P++K +P EVN AID L K+LTFNP R
Sbjct: 248 IREEDKDELLRVMPSFVSSTWEVKRPLRKLLP-------EVNSEAIDFLEKILTFNPMDR 300
Query: 296 ISAVEALEHPYLATYHDPDDEP 317
++A L+HPY++ Y P+DEP
Sbjct: 301 LTAEMGLQHPYMSPYSCPEDEP 322
>7297631 [T] KOG0665 Jun-N-terminal kinase (JNK)
Length = 372
Score = 213 bits (543), Expect = 3e-55
Identities = 140/366 (38%), Positives = 202/366 (54%), Gaps = 37/366 (10%)
Query: 7 YDIPSHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKI-QPFSRSMFVTRTLRELKLLKF 65
+ I S Y + +G GA G VC+A T VAIKK+ +PF R RE KL+K
Sbjct: 18 FTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKL 77
Query: 66 FHSHENIISVLDIVRPT-SWHKFEAVYLVQELMETDLQKIINQQNLSEDHIQYFVYQILR 124
+ H+NII +L+ P + +F+ VYLV ELM+ +L ++I Q +L D + Y +YQ+L
Sbjct: 78 VN-HKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVI-QMDLDHDRMSYLLYQMLC 135
Query: 125 ALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATR 184
+K LHSA +IHRDLKPSN+++ ++C LK+ DFGLAR ++ MT YV TR
Sbjct: 136 GIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTT--------FMMTPYVVTR 187
Query: 185 WYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLED 244
+YRAPE++L YT +DIWS GCI+ EMI G LFPG D+ Q I+E LG+P+
Sbjct: 188 YYRAPEVILG-MGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPS-PS 245
Query: 245 FEQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPL------------AIDLLSKMLTFNP 292
F Q + Y+ P G + + + P A +LLSKML +P
Sbjct: 246 FMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDP 305
Query: 293 DKRISAVEALEHPYLATYHDPDDEPDYPQLNLEDNFWKIDNEARDKNEEDDIPLELLKKM 352
++RIS EAL+H Y+ ++D +E D P D+ +E + +E K++
Sbjct: 306 EQRISVDEALKHEYINVWYDA-EEVDAPAPEPYDH----------SVDEREHTVEQWKEL 354
Query: 353 LYGEVM 358
+Y EVM
Sbjct: 355 IYEEVM 360
>CE27574 [T] KOG0665 Jun-N-terminal kinase (JNK)
Length = 463
Score = 213 bits (542), Expect = 4e-55
Identities = 126/328 (38%), Positives = 187/328 (56%), Gaps = 25/328 (7%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKI-QPFSRSMFVTRTLRELKLLKFFHSHEN 71
YQ + L+G GA G VCSA N +VAIKK+ +PF R RELKL+ + H+N
Sbjct: 119 YQNLRLIGSGAQGIVCSAFDTVRNEQVAIKKLSRPFQNVTHAKRAYRELKLMSLVN-HKN 177
Query: 72 IISVLDIVRPTS-WHKFEAVYLVQELMETDLQKIINQQNLSEDHIQYFVYQILRALKSLH 130
II +L+ P +F +Y+V ELM+ +L ++I Q +L + + Y +YQ+L ++ LH
Sbjct: 178 IIGILNCFTPQKKLDEFNDLYIVMELMDANLCQVI-QMDLDHERLSYLLYQMLCGIRHLH 236
Query: 131 SAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRAPE 190
SA +IHRDLKPSN+++ S+C LK+ DFGLAR + MT YV TR+YRAPE
Sbjct: 237 SAGIIHRDLKPSNIVVRSDCTLKILDFGLARTAIEA--------FMMTPYVVTRYYRAPE 288
Query: 191 IMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQIKS 250
++L Y +D+WS GCI E+I G+ LFPG D+ Q I+E LG+P E+++
Sbjct: 289 VILG-MGYKENVDVWSIGCIFGELIRGRVLFPGGDHIDQWTRIIEQLGTPDRSFLERLQ- 346
Query: 251 KRAKEYISQLPMKKGIPWANVLNKEVNPL-----------AIDLLSKMLTFNPDKRISAV 299
+ Y+ P + P+ + + + P+ A DLLS+ML +P++RIS
Sbjct: 347 PTVRNYVENRPRYQATPFEVLFSDNMFPMTADSSRLTGAQARDLLSRMLVIDPERRISVD 406
Query: 300 EALEHPYLATYHDPDDEPDYPQLNLEDN 327
+AL HPY+ + D + P L + N
Sbjct: 407 DALRHPYVNVWFDEIEVYAPPPLPYDHN 434
>CE29466 [T] KOG0665 Jun-N-terminal kinase (JNK)
Length = 390
Score = 210 bits (534), Expect = 3e-54
Identities = 139/330 (42%), Positives = 182/330 (55%), Gaps = 25/330 (7%)
Query: 6 TYDIPSHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQ-PFSRSMFVTRTLRELKLLK 64
T+ IP+ Y + + GA GTV A T +VAIKK+Q PF +M R RE LL
Sbjct: 31 TFTIPTRYVNLSFLNAGAQGTVVMADDLVTTQRVAIKKMQQPFVMTMSAKRAYREFILLT 90
Query: 65 FFHSHENIISVLDIVRP-TSWHKFEAVYLVQELMETDLQKIINQQNLSEDHIQYFVYQIL 123
H NII +L+ P TS F VYLV ELM +L ++I++ L + +FVYQ L
Sbjct: 91 TI-KHPNIIRLLNAFTPDTSLSTFREVYLVMELMTHNLHEVIHRLRLDHKTLSFFVYQSL 149
Query: 124 RALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVAT 183
A+K LH++ VIHRDLKPSN+++N C LKV DFGLAR R M++YV T
Sbjct: 150 CAIKHLHNSGVIHRDLKPSNIVVNDRCVLKVLDFGLARKKNVDTSMR------MSDYVVT 203
Query: 184 RWYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLE 243
R+YRAPE++L Y+ +DIWS GCI AEMI LFPGKD Q I VLG+P
Sbjct: 204 RYYRAPEVILGL-PYSEKVDIWSVGCIFAEMINHTVLFPGKDRIDQWTKIYSVLGTPDDH 262
Query: 244 DFEQIKSKRAKEYISQLPMKKG------IPWANVLNKEVNP-------LAIDLLSKMLTF 290
Q+ + A Y+ LP + +P N L + NP +A DLL ML
Sbjct: 263 FISQL-GQSAAMYVRSLPRHQARAFSEIVPDTNFLPETENPRVHLTPHVARDLLFNMLKI 321
Query: 291 NPDKRISAVEALEHPYLATYHDPDDEPDYP 320
NP++R S +AL HPY+ + DDE + P
Sbjct: 322 NPEERYSVEDALNHPYVKLWF-KDDEVNAP 350
>CE17305 [T] KOG0665 Jun-N-terminal kinase (JNK)
Length = 375
Score = 209 bits (533), Expect = 4e-54
Identities = 145/368 (39%), Positives = 197/368 (53%), Gaps = 40/368 (10%)
Query: 5 ITYDIPSHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQ-PFSRSMFVTRTLRELKLL 63
IT+ IP+ Y + + GA G V A T +VAIKK+Q PF +M R RE LL
Sbjct: 21 ITFTIPTRYVNLKFLNVGAQGIVVMADDLVTTQRVAIKKMQQPFLLTMSARRAYREFILL 80
Query: 64 KFFHSHENIISVLDIVRP-TSWHKFEAVYLVQELMETDLQKIINQQNLSEDHIQYFVYQI 122
H NII +L+ P TS F+ VYLV E M +L ++I++ L + + + VYQ
Sbjct: 81 TTL-KHPNIIRLLNAFTPDTSLSSFQEVYLVMEFMTHNLHEVIHRLRLDHETLSFLVYQS 139
Query: 123 LRALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVA 182
L A+K LH+ IHRDLKPSN+++N C LKV DFGLAR R N+ M++YV
Sbjct: 140 LCAIKHLHNLGFIHRDLKPSNIVVNERCVLKVLDFGLAR--------RRNVDMRMSDYVG 191
Query: 183 TRWYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTL 242
TR+YRAPE++L Y+ +DIWS GCILAEMI LFPGKD Q I VL +P
Sbjct: 192 TRYYRAPEVILGL-NYSEKVDIWSVGCILAEMINHTVLFPGKDIRDQWTQISSVLRTPDD 250
Query: 243 EDFEQIKSKRAKEYISQLP------MKKGIPWANVLNKEVNP-------LAIDLLSKMLT 289
Q++ A Y+ LP + +P +N L + NP +A DLL ML
Sbjct: 251 HFINQLEPIGA-VYVRSLPQHLARAFNEIVPDSNFLPETENPKDHLTLHMARDLLFNMLK 309
Query: 290 FNPDKRISAVEALEHPYLATYHDPDDEPDYPQLNLEDNFWKIDNEARDKNEEDDIPLELL 349
NP++R S +AL HPY DDE + P + D+ + N+ DD L
Sbjct: 310 INPEERYSVEDALNHPYTM-----DDEVNAPASEIPDD---------EVNDIDDWTLIEW 355
Query: 350 KKMLYGEV 357
K++++ EV
Sbjct: 356 KRLIFNEV 363
>Hs4506091 [T] KOG0660 Mitogen-activated protein kinase
Length = 721
Score = 207 bits (527), Expect = 2e-53
Identities = 125/321 (38%), Positives = 189/321 (57%), Gaps = 18/321 (5%)
Query: 7 YDIPSHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTLRELKLLKFF 66
+D+ S Y + +G G G V SA+ + +VAIKKI + V LRE+K+++
Sbjct: 14 FDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIV-LTDPQSVKHALREIKIIRRL 72
Query: 67 HSHENIISVLDIVRPT---------SWHKFEAVYLVQELMETDLQKIINQQNLSEDHIQY 117
H+NI+ V +I+ P+ S + +VY+VQE METDL ++ Q L E+H +
Sbjct: 73 -DHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARL 131
Query: 118 FVYQILRALKSLHSAQVIHRDLKPSNLLLNS-NCDLKVCDFGLARCLASSDQSRENMVGF 176
F+YQ+LR LK +HSA V+HRDLKP+NL +N+ + LK+ DFGLAR + + G
Sbjct: 132 FMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIM----DPHYSHKGH 187
Query: 177 MTEYVATRWYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEV 236
++E + T+WYR+P ++LS YT A+D+W+ GCI AEM+ GK LF G Q+ +ILE
Sbjct: 188 LSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILES 247
Query: 237 LGSPTLEDFEQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRI 296
+ ED +++ S YI + P +L ++ A+D L ++LTF+P R+
Sbjct: 248 IPVVHEEDRQELLSV-IPVYIRNDMTEPHKPLTQLL-PGISREALDFLEQILTFSPMDRL 305
Query: 297 SAVEALEHPYLATYHDPDDEP 317
+A EAL HPY++ Y P DEP
Sbjct: 306 TAEEALSHPYMSIYSFPMDEP 326
>Hs20502986 [T] KOG0660 Mitogen-activated protein kinase
Length = 277
Score = 206 bits (523), Expect = 6e-53
Identities = 119/271 (43%), Positives = 158/271 (57%), Gaps = 24/271 (8%)
Query: 9 IPSHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKI-QPFSRSMFVTRTLRELKLLKFFH 67
I Y L +G+GAYG V A+ + T VAIKKI F RT RE+ LL+ F
Sbjct: 9 IVRRYLLRRQLGQGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFG 68
Query: 68 SHENIISVLDIVRPTSWHKFEAVYLVQELM-----------------ETDLQKIINQQNL 110
H NIIS+LD++R + +YLV E M +TDL +I + L
Sbjct: 69 DHPNIISLLDVIRAENDRD---IYLVFEFMGCPPSPPPPTAVRTLSADTDLNAVIRKGGL 125
Query: 111 SED-HIQYFVYQILRALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQS 169
+D H++ YQ+LRA + LHS V+HRD KPSN+LL++NC +K+CDFGLAR L +
Sbjct: 126 LQDVHVRSIFYQLLRATRFLHSGHVVHRDQKPSNVLLDANCTVKLCDFGLARSLGDLPEG 185
Query: 170 RENMVGFMTEYVATRWYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQ 229
E+ +TEYVATRWYRAPE++LS YT +D+WS GCIL EM+ G+PLFPG HQ
Sbjct: 186 PEDQA--VTEYVATRWYRAPEVLLSSHRYTLGVDMWSLGCILGEMLRGRPLFPGTSTLHQ 243
Query: 230 LWIILEVLGSPTLEDFEQIKSKRAKEYISQL 260
L +ILE + P+ ED + S + QL
Sbjct: 244 LELILETIPPPSEEDLLALGSGCRASVLHQL 274
>7291043 [T] KOG0660 Mitogen-activated protein kinase
Length = 392
Score = 205 bits (522), Expect = 7e-53
Identities = 121/315 (38%), Positives = 180/315 (56%), Gaps = 10/315 (3%)
Query: 9 IPSHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKI-QPFSRSMFVTRTLRELKLLKFFH 67
+ S + + +G+GAYG V A + T VA+KK+ F RT RE+ L+ F
Sbjct: 21 VESIFDVRKRMGKGAYGIVWKATDRRTKNTVALKKVFDAFRDETDAQRTYREVIFLRAFR 80
Query: 68 SHENIISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQNLSED-HIQYFVYQILRAL 126
H NI+ ++DI + ++ F YLV E ME+DL +I + N+ +D H ++ +YQ++ A+
Sbjct: 81 CHPNIVRLVDIFKASNNLDF---YLVFEFMESDLHNVIKRGNVLKDVHKRFVMYQLINAI 137
Query: 127 KSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASS---DQSRENMVGFMTEYVAT 183
K +HS VIHRDLKPSN+L++S C LKV DFGLAR L+S D ++ G +T+YVAT
Sbjct: 138 KFIHSGNVIHRDLKPSNILIDSKCRLKVADFGLARTLSSRRIYDDLEQD--GMLTDYVAT 195
Query: 184 RWYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLE 243
RWYRAPEI+++ + YT +D+W GCIL EMI KPLF G +Q+ I+ L + T
Sbjct: 196 RWYRAPEILVASRNYTKGIDMWGLGCILGEMIRQKPLFQGTSTVNQIEKIVTSLPNVTKL 255
Query: 244 DFEQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALE 303
D I +S+ + + + K I L+ +L NP R++A EA+
Sbjct: 256 DIASIGPSFGSVLLSRNIQRDRRYSLDEMMKNCCDDGISLVKALLVLNPHNRLTAKEAIR 315
Query: 304 HPYLATYHDPDDEPD 318
HPY++ + E D
Sbjct: 316 HPYVSRFQYASAEMD 330
>CE27220 [T] KOG0660 Mitogen-activated protein kinase
Length = 472
Score = 198 bits (503), Expect = 1e-50
Identities = 110/309 (35%), Positives = 180/309 (57%), Gaps = 16/309 (5%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRS-MFVTRTLRELKLLKFFHSHEN 71
Y+ +G GA+G VC A+ +N KVAIKK+ S + RTLRE+++L++ + H N
Sbjct: 82 YEPTQNIGSGAFGIVCEAVETSSNQKVAIKKVAHASATPTLARRTLREIRVLRYIN-HPN 140
Query: 72 IISVLDIVRPTSWHKFEAVYLVQELMETDLQKII--NQQNLSEDHIQYFVYQILRALKSL 129
I+ + DI R + V+LV +LM+ +L II N+ L E +I F+ Q+LR L+ L
Sbjct: 141 IVPLRDIFRTKGPLGID-VFLVMDLMQNNLHHIIYGNEDPLEEHYINAFLGQLLRGLEYL 199
Query: 130 HSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSR--ENMVGFMTEYVATRWYR 187
H+A + HRDLKPSNLL+N + L++ DFG+A+C +S + E +MT++VAT YR
Sbjct: 200 HAACIAHRDLKPSNLLVNQDGTLRIADFGMAKCADNSSKKHDDEEHCYYMTQHVATLPYR 259
Query: 188 APEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQ 247
APE++ E++TA+D+W+ GCI EM++ + PG+ Q+ ++L +LG P E +
Sbjct: 260 APELLFVLPEHSTAVDMWAVGCIFGEMVIRNEILPGRSVQGQIKMLLTMLGQPPQEVINE 319
Query: 248 IKSKRAKEYISQLPMKKGIPWANVLNKEV---------NPLAIDLLSKMLTFNPDKRISA 298
++ R ++ I K W +++ + N ID + ++ ++ KRI+
Sbjct: 320 VRCDRTRKLIQDFGRKADAEWDDIMFCKARGDDQIVRGNCDTIDFVKQLFQYDAQKRINI 379
Query: 299 VEALEHPYL 307
+AL HPY+
Sbjct: 380 QDALLHPYI 388
>SPAC2F3.15 [D] KOG0600 Cdc2-related protein kinase
Length = 593
Score = 196 bits (498), Expect = 4e-50
Identities = 124/336 (36%), Positives = 190/336 (55%), Gaps = 18/336 (5%)
Query: 4 TITYDIPSHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQ-PFSRSMFVTRTLRELKL 62
T TY P+ Y+ +D +GEG YG V AI+ T VA+K+I+ + F T+RE+K+
Sbjct: 269 TYTYPKPA-YEKIDQIGEGTYGKVYKAINTVTGDLVALKRIRLEQEKDGFPITTVREVKI 327
Query: 63 LKFFHSHENIISVLDIVRPTSWHKFEAVYLVQELMETDLQKII--NQQNLSEDHIQYFVY 120
L+ H+NI+ +L+I+ S +VY+V E M+ DL ++ +Q + + +I++
Sbjct: 328 LQRLR-HKNIVRLLEIMVEKS-----SVYMVFEYMDHDLTGVLLNSQLHFTPGNIKHLSK 381
Query: 121 QILRALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEY 180
QI AL LH V+HRD+K SN+LLN+N DLK DFGLAR SS + T
Sbjct: 382 QIFEALAYLHHRGVLHRDIKGSNILLNNNGDLKFADFGLARFNTSSKSAN------YTNR 435
Query: 181 VATRWYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSP 240
V T W+R PE++L Y TA+DIWS GCI+ E+ GKP F G+D QL +I +++G+P
Sbjct: 436 VITLWFRPPELLLGETAYDTAVDIWSAGCIVMELFTGKPFFQGRDEISQLEVIYDMMGTP 495
Query: 241 TLEDFEQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVE 300
+ + ++K+ E + + KK + + ++P AIDL K+L NP R SA E
Sbjct: 496 DVHSWPEVKNLPWYELLKPVEEKKS-RFVETFKEILSPAAIDLCQKLLALNPFCRPSAHE 554
Query: 301 ALEHPYLATYHDPDDEPDYPQLNLEDNFWKIDNEAR 336
L H Y T P EP N++ ++ + +++ R
Sbjct: 555 TLMHEYF-TSESPPPEPAVILKNMQGSWHEWESKKR 589
>YPL031c [R] KOG0594 Protein kinase PCTAIRE and related kinases
Length = 305
Score = 189 bits (481), Expect = 4e-48
Identities = 109/310 (35%), Positives = 173/310 (55%), Gaps = 22/310 (7%)
Query: 11 SHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTLRELKLLKFFHSHE 70
S ++ ++ +G G Y TV ++K T VA+K+++ S + +RE+ L+K HE
Sbjct: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKEL-KHE 63
Query: 71 NIISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQNLSE-------DHIQYFVYQIL 123
NI+ + D++ H + LV E M+ DL+K ++ + + + ++YF +Q+L
Sbjct: 64 NIVRLYDVI-----HTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLL 118
Query: 124 RALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVAT 183
+ L H +++HRDLKP NLL+N LK+ DFGLAR V + V T
Sbjct: 119 QGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIP-------VNTFSSEVVT 171
Query: 184 RWYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLE 243
WYRAP++++ + Y+T++DIWSCGCILAEMI GKPLFPG + QL +I +++G+P
Sbjct: 172 LWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNES 231
Query: 244 DFEQI-KSKRAKEYISQLPMKKGIPWANVLNKE-VNPLAIDLLSKMLTFNPDKRISAVEA 301
+ + K + I Q P + KE ++ +D L +L NPD R+SA +A
Sbjct: 232 LWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQA 291
Query: 302 LEHPYLATYH 311
L HP+ A Y+
Sbjct: 292 LHHPWFAEYY 301
>At3g48750 [R] KOG0594 Protein kinase PCTAIRE and related kinases
Length = 294
Score = 188 bits (478), Expect = 9e-48
Identities = 123/299 (41%), Positives = 169/299 (56%), Gaps = 21/299 (7%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRT-LRELKLLKFFHSHEN 71
Y+ V+ +GEG YG V A K TN +A+KKI+ V T +RE+ LLK H N
Sbjct: 4 YEKVEKIGEGTYGVVYKARDKVTNETIALKKIRLEQEDEGVPSTAIREISLLKEMQ-HSN 62
Query: 72 IISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQ-NLSED--HIQYFVYQILRALKS 128
I+ D+V H + +YLV E ++ DL+K ++ + S+D I+ ++YQILR +
Sbjct: 63 IVKYDDVV-----HSEKRLYLVFEYLDLDLKKHMDSTPDFSKDLHMIKTYLYQILRGIAY 117
Query: 129 LHSAQVIHRDLKPSNLLLNSNCD-LKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYR 187
HS +V+HRDLKP NLL++ + LK+ DFGLAR V T V T WYR
Sbjct: 118 CHSHRVLHRDLKPQNLLIDRRTNSLKLADFGLARAFGIP-------VRTFTHEVVTLWYR 170
Query: 188 APEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQ 247
APEI+L Y+T +DIWS GCI AEMI KPLFPG QL+ I ++G+P + +
Sbjct: 171 APEILLGSHHYSTPVDIWSVGCIFAEMISQKPLFPGDSEIDQLFKIFRIMGTPYEDTWRG 230
Query: 248 IKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEHPY 306
+ S +Y S P K + ++P +DLLSKML +P KRI+A ALEH Y
Sbjct: 231 VTS--LPDYKSAFPKWKPTDLETFV-PNLDPDGVDLLSKMLLMDPTKRINARAALEHEY 286
>SPBC18H10.15 [R] KOG0663 Protein kinase PITSLRE and related kinases
Length = 398
Score = 186 bits (471), Expect = 6e-47
Identities = 125/335 (37%), Positives = 183/335 (54%), Gaps = 30/335 (8%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSM-FVTRTLRELKLLKFFHSHEN 71
Y++++ + EG+YG V + K TNT VA+KKI+ + F +LRE++ L H+N
Sbjct: 74 YEILEKIEEGSYGIVYRGLDKSTNTLVALKKIKFDPNGIGFPITSLREIESLSSIR-HDN 132
Query: 72 IISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQNLSEDHIQYFV----YQILRALK 127
I+ + +V + VYLV E ME DL+ +++ N+ ED +Q V Q+L A
Sbjct: 133 IVELEKVVVGKD---LKDVYLVMEFMEHDLKTLLD--NMPEDFLQSEVKTLMLQLLAATA 187
Query: 128 SLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYR 187
+H +HRDLKPSNLL+N+ ++K+ DFGLAR ++ S +T V T WYR
Sbjct: 188 FMHHHWYLHRDLKPSNLLMNNTGEIKLADFGLARPVSEPKSS-------LTRLVVTLWYR 240
Query: 188 APEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQ 247
APE++L Y +D+WS GCI AEMI PLF GK QL+ I +LG PT E++ Q
Sbjct: 241 APELLLGAPSYGKEIDMWSIGCIFAEMITRTPLFSGKSELDQLYKIFNLLGYPTREEWPQ 300
Query: 248 IKSKRAKEYISQLPMKKGIPWANVLNKEVNPL---AIDLLSKMLTFNPDKRISAVEALEH 304
Y +++ +P + + + L A DLL+++L+ NP KRISA EALEH
Sbjct: 301 Y---FLLPYANKI-KHPTVPTHSKIRTSIPNLTGNAYDLLNRLLSLNPAKRISAKEALEH 356
Query: 305 PYLATYHDPDDEPDYPQLNLEDNFWKIDNEARDKN 339
PY P D +P K E+++KN
Sbjct: 357 PYFYESPRPKDPKFFPTFPS-----KAKGESKEKN 386
>At5g26751 [G] KOG0658 Glycogen synthase kinase-3
Length = 413
Score = 185 bits (469), Expect = 1e-46
Identities = 117/349 (33%), Positives = 187/349 (53%), Gaps = 25/349 (7%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTLRELKLLKFFHSHENI 72
Y +VG G++G V A T VAIKK+ R + R L+ ++LL H N+
Sbjct: 69 YMAERVVGHGSFGVVFQAKCLETGETVAIKKVLQDRR--YKNRELQTMRLL----DHPNV 122
Query: 73 ISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQNLSED-----HIQYFVYQILRALK 127
+S+ T+ + LV E + + ++I N +++ + YQI RAL
Sbjct: 123 VSLKHCFFSTTEKDELYLNLVLEYVPETVHRVIKHYNKLNQRMPLIYVKLYTYQIFRALS 182
Query: 128 SLHSA-QVIHRDLKPSNLLLNSNC-DLKVCDFGLARCLASSDQSRENMVGFMTEYVATRW 185
+H V HRD+KP NLL+N + +K+CDFG A+ L + + Y+ +R+
Sbjct: 183 YIHRCIGVCHRDIKPQNLLVNPHTHQVKLCDFGSAKVLVKGEPN--------ISYICSRY 234
Query: 186 YRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDF 245
YRAPE++ EYTTA+D+WS GC+LAE+++G+PLFPG+ QL I++VLG+PT
Sbjct: 235 YRAPELIFGATEYTTAIDVWSAGCVLAELLLGQPLFPGESGVDQLVEIIKVLGTPTR--- 291
Query: 246 EQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEHP 305
E+IK + P K PW + +K + P A+DL+S++L ++P+ R +A++ L HP
Sbjct: 292 EEIKCMNPNYTEFKFPQIKAHPWHKIFHKRMPPEAVDLVSRLLQYSPNLRSAALDTLVHP 351
Query: 306 YLATYHDPDDE-PDYPQLNLEDNFWKIDNEARDKNEEDDIPLELLKKML 353
+ DP+ P+ L NF + NE +PLE++ K++
Sbjct: 352 FFDELRDPNARLPNGRFLPPLFNFKPHGTTSPFPNELKGVPLEMVAKLV 400
>At1g67580 [R] KOG0663 Protein kinase PITSLRE and related kinases
Length = 752
Score = 185 bits (469), Expect = 1e-46
Identities = 117/327 (35%), Positives = 182/327 (54%), Gaps = 26/327 (7%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQ-PFSRSMFVTRTLRELKLLKFFHSHEN 71
++ ++ + EG YG V A K T VA+KK++ R F +LRE+ +L FH H +
Sbjct: 406 FERLNKIDEGTYGVVYRAKDKKTGEIVALKKVKMEKEREGFPLTSLREINILLSFH-HPS 464
Query: 72 IISVLDIVRPTSWHKFEAVYLVQELMETDLQKIIN--QQNLSEDHIQYFVYQILRALKSL 129
I+ V ++V +S +++++V E ME DL+ ++ +Q S+ ++ + Q+L +K L
Sbjct: 465 IVDVKEVVVGSS---LDSIFMVMEYMEHDLKALMETMKQRFSQSEVKCLMLQLLEGVKYL 521
Query: 130 HSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRAP 189
H V+HRDLK SNLLLN+ +LK+CDFGLAR S + T V T WYRAP
Sbjct: 522 HDNWVLHRDLKTSNLLLNNRGELKICDFGLARQYGSPLKP-------YTHLVVTLWYRAP 574
Query: 190 EIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPT------LE 243
E++L ++Y+TA+D+WS GCI+AE++M PLF GK QL I +LG+P
Sbjct: 575 ELLLGAKQYSTAIDMWSLGCIMAELLMKAPLFNGKTEFDQLDKIFRILGTPNESIWPGFS 634
Query: 244 DFEQIKSKRAKEYISQLPMKKGIPWANVLNKEV-NPLAIDLLSKMLTFNPDKRISAVEAL 302
+K K + L +K P + V + DLL+K+LT++P++RI+ EAL
Sbjct: 635 KLPGVKVNFVKHQYNLL--RKKFPATSFTGAPVLSDAGFDLLNKLLTYDPERRITVNEAL 692
Query: 303 EHPYLATYHDP---DDEPDYPQLNLED 326
+H + P D P +P + +D
Sbjct: 693 KHDWFREVPLPKSKDFMPTFPAQHAQD 719
>SPBC11B10.09 [R] KOG0594 Protein kinase PCTAIRE and related kinases
Length = 297
Score = 184 bits (466), Expect = 2e-46
Identities = 119/311 (38%), Positives = 175/311 (56%), Gaps = 27/311 (8%)
Query: 12 HYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRT-LRELKLLKFFH--- 67
+YQ V+ +GEG YG V A HK + VA+KKI+ S V T +RE+ LLK +
Sbjct: 3 NYQKVEKIGEGTYGVVYKARHKLSGRIVAMKKIRLEDESEGVPSTAIREISLLKEVNDEN 62
Query: 68 SHENIISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQ------QNLSEDHIQYFVYQ 121
+ N + +LDI+ H +YLV E ++ DL+K +++ +L +Q F YQ
Sbjct: 63 NRSNCVRLLDIL-----HAESKLYLVFEFLDMDLKKYMDRISETGATSLDPRLVQKFTYQ 117
Query: 122 ILRALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYV 181
++ + HS ++IHRDLKP NLL++ +LK+ DFGLAR ++ T +
Sbjct: 118 LVNGVNFCHSRRIIHRDLKPQNLLIDKEGNLKLADFGLARSFGVPLRN-------YTHEI 170
Query: 182 ATRWYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPT 241
T WYRAPE++L + Y+T +DIWS GCI AEMI PLFPG +++ I +VLG+P
Sbjct: 171 VTLWYRAPEVLLGSRHYSTGVDIWSVGCIFAEMIRRSPLFPGDSEIDEIFKIFQVLGTPN 230
Query: 242 LEDFEQIKSKRAKEYISQLPMKKGIPWANVL-NKEVNPLAIDLLSKMLTFNPDKRISAVE 300
E + + ++Y S P K + V+ N E + AI+LLS ML ++P RISA
Sbjct: 231 EEVWPGV--TLLQDYKSTFPRWKRMDLHKVVPNGEED--AIELLSAMLVYDPAHRISAKR 286
Query: 301 ALEHPYLATYH 311
AL+ YL +H
Sbjct: 287 ALQQNYLRDFH 297
>Hs4502709 [R] KOG0594 Protein kinase PCTAIRE and related kinases
Length = 297
Score = 183 bits (464), Expect = 4e-46
Identities = 117/310 (37%), Positives = 173/310 (55%), Gaps = 26/310 (8%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRT-LRELKLLKFFHSHEN 71
Y ++ +GEG YG V HK T VA+KKI+ S V T +RE+ LLK H N
Sbjct: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELR-HPN 62
Query: 72 IISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQ----QNLSEDHIQYFVYQILRALK 127
I+S+ D++ S +YL+ E + DL+K ++ Q + ++ ++YQIL+ +
Sbjct: 63 IVSLQDVLMQDS-----RLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIV 117
Query: 128 SLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYR 187
HS +V+HRDLKP NLL++ +K+ DFGLAR + T V T WYR
Sbjct: 118 FCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIP-------IRVYTHEVVTLWYR 170
Query: 188 APEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQ 247
+PE++L Y+T +DIWS G I AE+ KPLF G QL+ I LG+P E + +
Sbjct: 171 SPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPE 230
Query: 248 IKSKRAKEYISQLP-MKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEHPY 306
++S ++Y + P K G ++V N + N +DLLSKML ++P KRIS AL HPY
Sbjct: 231 VES--LQDYKNTFPKWKPGSLASHVKNLDEN--GLDLLSKMLIYDPAKRISGKMALNHPY 286
Query: 307 LATYHDPDDE 316
++D D++
Sbjct: 287 ---FNDLDNQ 293
>Hs16936528 [R] KOG0594 Protein kinase PCTAIRE and related kinases
Length = 298
Score = 182 bits (462), Expect = 7e-46
Identities = 122/310 (39%), Positives = 173/310 (55%), Gaps = 28/310 (9%)
Query: 12 HYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRT-LRELKLLKFFHSHE 70
++Q V+ +GEG YG V A +K T VA+KKI+ + + V T +RE+ LLK + H
Sbjct: 3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELN-HP 61
Query: 71 NIISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQNLSE---DHIQYFVYQILRALK 127
NI+ +LD++ H +YLV E + DL+K ++ L+ I+ +++Q+L+ L
Sbjct: 62 NIVKLLDVI-----HTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLA 116
Query: 128 SLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYR 187
HS +V+HRDLKP NLL+N+ +K+ DFGLAR V T V T WYR
Sbjct: 117 FCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVP-------VRTYTHEVVTLWYR 169
Query: 188 APEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQ 247
APEI+L + Y+TA+DIWS GCI AEM+ + LFPG QL+ I LG+P +
Sbjct: 170 APEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPG 229
Query: 248 IKSKRAKEYISQLPMKKGIPWANV-LNKEVNPLAID---LLSKMLTFNPDKRISAVEALE 303
+ S +Y P WA +K V PL D LLS+ML ++P+KRISA AL
Sbjct: 230 VTS--MPDYKPSFP-----KWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALA 282
Query: 304 HPYLATYHDP 313
HP+ P
Sbjct: 283 HPFFQDVTKP 292
>Hs4557439 [R] KOG0594 Protein kinase PCTAIRE and related kinases
Length = 305
Score = 181 bits (459), Expect = 1e-45
Identities = 123/323 (38%), Positives = 176/323 (54%), Gaps = 35/323 (10%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRT-LRELKLLKFFHSHEN 71
+Q V+ +GEG YG V A ++ T VA+KKI+ V T +RE+ LLK H N
Sbjct: 4 FQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKEL-KHPN 62
Query: 72 IISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQNLSE---DHIQYFVYQILRALKS 128
I+ +LD+V H +YLV E + DL+K ++ SE I+ +++Q+L+ +
Sbjct: 63 IVRLLDVV-----HNERKLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSF 117
Query: 129 LHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRA 188
HS +VIHRDLKP NLL+N +K+ DFGLAR ++ T V T WYRA
Sbjct: 118 CHSHRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRT-------YTHEVVTLWYRA 170
Query: 189 PEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQI 248
PEI+L + YTTA+DIWS GCI AEM+ K LFPG QL+ I +LG+P+ + +
Sbjct: 171 PEILLGSKFYTTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPG- 229
Query: 249 KSKRAKEYISQLPMKKGI--PWANVLNKEV----NPLAIDLLSKMLTFNPDKRISAVEAL 302
++QLP KG W +E+ P DLL ++L ++P +RI+A AL
Sbjct: 230 --------VTQLPDYKGSFPKWTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTAL 281
Query: 303 EHPYLATYHDPDDEPDYPQLNLE 325
HPY + P+ P Q L+
Sbjct: 282 AHPY---FSSPEPSPAARQYVLQ 301
>Hs4502743 [DKL] KOG0659 Cdk activating kinase (CAK)/RNA polymerase II
transcription initiation/nucleotide excision repair
factor TFIIH/TFIIK kinase subunit CDK7
Length = 346
Score = 180 bits (457), Expect = 3e-45
Identities = 122/317 (38%), Positives = 174/317 (54%), Gaps = 23/317 (7%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMF---VTRT-LRELKLLKFFHS 68
Y+ +D +GEG + TV A K TN VAIKKI+ RS + RT LRE+KLL+ S
Sbjct: 12 YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL-S 70
Query: 69 HENIISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQNL--SEDHIQYFVYQILRAL 126
H NII +LD HK + LV + METDL+ II +L + HI+ ++ L+ L
Sbjct: 71 HPNIIGLLDAFG----HKSN-ISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGL 125
Query: 127 KSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWY 186
+ LH ++HRDLKP+NLLL+ N LK+ DFGLA+ S +++ T V TRWY
Sbjct: 126 EYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRA-------YTHQVVTRWY 178
Query: 187 RAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFE 246
RAPE++ + Y +D+W+ GCILAE+++ P PG QL I E LG+PT E +
Sbjct: 179 RAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWP 238
Query: 247 QIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEHPY 306
+ S P GIP ++ + + L +DL+ + FNP RI+A +AL+ Y
Sbjct: 239 DMCSLPDYVTFKSFP---GIPLHHIFSAAGDDL-LDLIQGLFLFNPCARITATQALKMKY 294
Query: 307 LATYHDPDDEPDYPQLN 323
+ P P+ N
Sbjct: 295 FSNRPGPTPGCQLPRPN 311
>At3g05840 [G] KOG0658 Glycogen synthase kinase-3
Length = 409
Score = 180 bits (456), Expect = 3e-45
Identities = 106/309 (34%), Positives = 171/309 (55%), Gaps = 24/309 (7%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTLRELKLLKFFHSHENI 72
Y +VG G++G V A T VAIKK+ R + R L+ ++LL H N+
Sbjct: 73 YMAERVVGHGSFGVVFQAKCLETGETVAIKKVLQDRR--YKNRELQTMRLL----DHPNV 126
Query: 73 ISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQNLSED-----HIQYFVYQILRALK 127
+S+ T+ + LV E + + ++I N +++ + YQI R+L
Sbjct: 127 VSLKHCFFSTTEKDELYLNLVLEYVPETVHRVIKHYNKLNQRMPLVYVKLYTYQIFRSLS 186
Query: 128 SLHSA-QVIHRDLKPSNLLLNSNC-DLKVCDFGLARCLASSDQSRENMVGFMTEYVATRW 185
+H V HRD+KP NLL+N + +K+CDFG A+ L + + Y+ +R+
Sbjct: 187 YIHRCIGVCHRDIKPQNLLVNPHTHQVKLCDFGSAKVLVKGEPN--------ISYICSRY 238
Query: 186 YRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDF 245
YRAPE++ EYTTA+D+WS GC+LAE+++G+PLFPG+ QL I++VLG+PT
Sbjct: 239 YRAPELIFGATEYTTAIDVWSAGCVLAELLLGQPLFPGESGVDQLVEIIKVLGTPTR--- 295
Query: 246 EQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEHP 305
E+IK + P K PW + +K + P A+DL+S++L ++P+ R +A+++L HP
Sbjct: 296 EEIKCMNPNYTEFKFPQIKAHPWHKIFHKRMPPEAVDLVSRLLQYSPNLRCAALDSLVHP 355
Query: 306 YLATYHDPD 314
+ DP+
Sbjct: 356 FFDELRDPN 364
>Hs4826675 [UT] KOG0662 Cyclin-dependent kinase CDK5
Length = 292
Score = 179 bits (454), Expect = 6e-45
Identities = 113/305 (37%), Positives = 171/305 (56%), Gaps = 20/305 (6%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFV-TRTLRELKLLKFFHSHEN 71
Y+ ++ +GEG YGTV A ++ T+ VA+K+++ V + LRE+ LLK H+N
Sbjct: 4 YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKEL-KHKN 62
Query: 72 IISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQN--LSEDHIQYFVYQILRALKSL 129
I+ + D++ H + + LV E + DL+K + N L + ++ F++Q+L+ L
Sbjct: 63 IVRLHDVL-----HSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFC 117
Query: 130 HSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRAP 189
HS V+HRDLKP NLL+N N +LK+ DFGLAR V + V T WYR P
Sbjct: 118 HSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIP-------VRCYSAEVVTLWYRPP 170
Query: 190 EIMLSFQEYTTAMDIWSCGCILAEMI-MGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQI 248
+++ + Y+T++D+WS GCI AE+ G+PLFPG D QL I +LG+PT E + +
Sbjct: 171 DVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSM 230
Query: 249 KSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEHPYLA 308
+ P + NV+ K +N DLL +L NP +RISA EAL+HPY +
Sbjct: 231 TKLPDYKPYPMYPATTSL--VNVVPK-LNATGRDLLQNLLKCNPVQRISAEEALQHPYFS 287
Query: 309 TYHDP 313
+ P
Sbjct: 288 DFCPP 292
>7300773 [DKL] KOG0659 Cdk activating kinase (CAK)/RNA polymerase II
transcription initiation/nucleotide excision repair
factor TFIIH/TFIIK kinase subunit CDK7
Length = 302
Score = 178 bits (452), Expect = 1e-44
Identities = 106/294 (36%), Positives = 163/294 (55%), Gaps = 15/294 (5%)
Query: 10 PSHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSR-SMFVTRTLRELKLLKFFHS 68
PS Y++++ +GEG +G V AI N +VAIKK+ ++ TLRE+K L+ S
Sbjct: 6 PSRYKMLEKIGEGVHGCVFKAIDLQRNKEVAIKKVALKNKFGNIALNTLREIKTLQLCKS 65
Query: 69 HENIISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQ--NLSEDHIQYFVYQILRAL 126
E I+ ++DI + + LV E L + + LS ++ F +Q+ + +
Sbjct: 66 -EYILDIIDI-----YPDLTGLSLVLEYQPDTLYNRLKSEVNPLSRQQVRKFAHQMFKGI 119
Query: 127 KSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWY 186
LH A ++HRD+KP+NLL++ LK+ DFGLAR D+SR + V+TRWY
Sbjct: 120 AYLHEAGLMHRDIKPANLLISDTDMLKIADFGLARLYFPEDESR-----LYSPQVSTRWY 174
Query: 187 RAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFE 246
RAPEI+ Q+Y T +D+W+ GC++AEM+ G PLF G QL II+ LGSP L +
Sbjct: 175 RAPEILFGSQKYGTGVDMWAAGCVVAEMLRGVPLFAGTTDIEQLAIIIRTLGSPRLNQWP 234
Query: 247 QIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVE 300
++ S I + P GI W N+ + + I+L+S ++ +NP R+ A E
Sbjct: 235 ELTSLPDYSKI-RFPNSVGIHWDNLFPSCTHAVEINLVSNLVVYNPKNRLKASE 287
>CE26422 [D] KOG0600 Cdc2-related protein kinase
Length = 684
Score = 178 bits (451), Expect = 1e-44
Identities = 108/320 (33%), Positives = 176/320 (54%), Gaps = 26/320 (8%)
Query: 11 SHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQ-PFSRSMFVTRTLRELKLLKFFHSH 69
+HY ++D +GEG YG V A++ T +VA+K+++ + F +RE+K+L+ H H
Sbjct: 309 THYTMLDQIGEGTYGQVYKAVNNLTGEQVALKRVRLENEKEGFPITAIREIKILRQLH-H 367
Query: 70 ENIISVLDIV-RPTSWHKFEAV----YLVQELMETDLQKIINQQNL---SEDHIQYFVYQ 121
+NI+ ++DIV S + + YLV E ++ DL ++ + L ++D I Q
Sbjct: 368 KNIVRLMDIVIDDISMDELKRTRANFYLVFEYVDHDLIGLLESKELVDFNKDQICSLFKQ 427
Query: 122 ILRALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYV 181
+L L +H+ +HRD+K SN+L+N+ +LK+ D GLAR + T V
Sbjct: 428 LLEGLAYIHNTGFLHRDIKCSNILVNNKGELKIADLGLARLWEKESR-------LYTNRV 480
Query: 182 ATRWYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPT 241
T WYR PE++L + Y A+D+WS GC+L E+ KPLF G + QL +I +V GSP
Sbjct: 481 ITLWYRPPELLLGDERYGPAIDVWSTGCMLGELFTRKPLFNGNNEFGQLELISKVCGSPN 540
Query: 242 LEDFEQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPL----AIDLLSKMLTFNPDKRIS 297
++++ ++ E + + + + +E + A+DLL KMLT NP+KRIS
Sbjct: 541 VDNWPEL-----TELVGWNTFRMKRTYQRRIREEFEHIMPREAVDLLDKMLTLNPEKRIS 595
Query: 298 AVEALEHPYLATYHDPDDEP 317
A EAL HP++ + +P
Sbjct: 596 AKEALNHPWIRSLEHTTVQP 615
>7290565 [DKL] KOG0659 Cdk activating kinase (CAK)/RNA polymerase II
transcription initiation/nucleotide excision repair
factor TFIIH/TFIIK kinase subunit CDK7
Length = 353
Score = 176 bits (447), Expect = 4e-44
Identities = 116/319 (36%), Positives = 175/319 (54%), Gaps = 23/319 (7%)
Query: 8 DIPSHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMF---VTRT-LRELKLL 63
D Y + +GEG + TV A TN VA+KKI+ SR + RT LRE+K+L
Sbjct: 7 DKTERYAKLSFLGEGQFATVYKARDTVTNQIVAVKKIKKGSREDARDGINRTALREIKIL 66
Query: 64 KFFHSHENIISVLDIVRPTSWHKFEAVYLVQELMETDLQKII--NQQNLSEDHIQYFVYQ 121
+ HENII ++D+ + + V LV + M+TDL+ II N+ L++ +I+ +
Sbjct: 67 QELQ-HENIIGLVDV-----FGQLSNVSLVFDFMDTDLEVIIKDNKIILTQANIKAYAIM 120
Query: 122 ILRALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYV 181
L+ L+ LH ++HRDLKP+NLL+NS+ LK+ DFGLA+ S ++ T +V
Sbjct: 121 TLKGLEYLHLNWILHRDLKPNNLLVNSDGILKIGDFGLAKSFGSPNR-------IYTHHV 173
Query: 182 ATRWYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPT 241
TRWYR+PE++ ++Y T +D+W+ GCILAE+++ P PG QL I LG+PT
Sbjct: 174 VTRWYRSPELLFGARQYGTGVDMWAVGCILAELMLRVPFMPGDSDLDQLTRIFSTLGTPT 233
Query: 242 LEDFEQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEA 301
++ + + +Y+ Q G P N+ N L I L+ ++ NP +R+S EA
Sbjct: 234 EAEWPHL--SKLHDYL-QFRNFPGTPLDNIFTAAGNDL-IHLMQRLFAMNPLRRVSCREA 289
Query: 302 LEHPYLATYHDPDDEPDYP 320
L PY A P P P
Sbjct: 290 LSMPYFANKPAPTVGPKLP 308
>SPCC16C4.11 [R] KOG0594 Protein kinase PCTAIRE and related kinases
Length = 288
Score = 175 bits (444), Expect = 8e-44
Identities = 109/302 (36%), Positives = 166/302 (54%), Gaps = 20/302 (6%)
Query: 12 HYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTLRELKLLKFFHSHEN 71
+YQ ++ +GEG Y V ++ T VA+K I+ + + +RE+ L+K H N
Sbjct: 2 NYQRLEKLGEGTYAHVYKGQNRVTGEIVALKVIRIDADEGTPSTAIREISLMKELR-HPN 60
Query: 72 IISVLDIVRPTSWHKFEAVYLVQELMETDLQKII----NQQNLSEDHIQYFVYQILRALK 127
I+S+ D+++ + + LV E ME DL+K + NQ L ++ F Q+L+ +
Sbjct: 61 IMSLSDVLQTEN-----KLMLVFEYMEKDLKKYMDTYGNQGALPPSQVKNFTQQLLKGIS 115
Query: 128 SLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYR 187
H +V+HRDLKP NLL+NS +LK+ DFGLAR + V + V T WYR
Sbjct: 116 FCHENRVLHRDLKPQNLLINSRGELKLADFGLARSIGIP-------VNTFSNEVVTLWYR 168
Query: 188 APEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQ 247
AP+++L + Y+T++DIWS GCI+AEM G+PLF G + QL I +LG+PT + +
Sbjct: 169 APDVLLGSRVYSTSIDIWSVGCIMAEMATGRPLFAGSNNEDQLLKIFRLLGTPTEQSWPG 228
Query: 248 IKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEHPYL 307
I EY P+ K A L +PL +DLL +ML P+ R + +AL+H +
Sbjct: 229 I--SLLPEYKPTFPIYKAQDLA-YLFPTFDPLGLDLLRRMLRLQPELRTTGQDALQHAWF 285
Query: 308 AT 309
T
Sbjct: 286 LT 287
>SPAC1687.15 [G] KOG0658 Glycogen synthase kinase-3
Length = 387
Score = 175 bits (443), Expect = 1e-43
Identities = 106/309 (34%), Positives = 176/309 (56%), Gaps = 24/309 (7%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTLRELKLLKFFHSHENI 72
Y +VG G++G V +++K AIK++ R F R L+ ++++K H NI
Sbjct: 32 YTSSKVVGSGSFGVVMQVHLIESDSKAAIKRVLQDKR--FKNRELQIMRIMK----HPNI 85
Query: 73 ISVLDIVRPTSWHKFEA-VYLVQELMETDL---QKIINQQNLSED--HIQYFVYQILRAL 126
+ ++ T + E + LV E M + ++ +Q LS ++ ++YQ+LR+L
Sbjct: 86 VDLIAYYYTTGDNSDEVYLNLVLEFMPETIYRASRLYTRQKLSMPMLEVKLYIYQLLRSL 145
Query: 127 KSLHSAQVIHRDLKPSNLLLN-SNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRW 185
+H++ + HRD+KP NLLL+ N LK+CDFG A+ L + + + Y+ +R+
Sbjct: 146 AYIHASGICHRDIKPQNLLLDPENGILKLCDFGSAKILVAGEPN--------VSYICSRY 197
Query: 186 YRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDF 245
YRAPE++ +YT A+DIWS GC++AE+++G PLFPG+ QL I+++LG+P+
Sbjct: 198 YRAPELIFGATDYTHAIDIWSTGCVMAELMLGHPLFPGESGIDQLVEIIKILGTPSR--- 254
Query: 246 EQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEHP 305
EQIK+ + P + P + V ++ V A+DLLSKML + P R++A EA+ HP
Sbjct: 255 EQIKTMNPNYMEHRFPQIRPQPLSRVFSRSVPLDALDLLSKMLQYTPTDRLTAAEAMCHP 314
Query: 306 YLATYHDPD 314
+ DP+
Sbjct: 315 FFDELRDPN 323
>At5g63370 [R] KOG0663 Protein kinase PITSLRE and related kinases
Length = 612
Score = 174 bits (442), Expect = 1e-43
Identities = 114/327 (34%), Positives = 179/327 (53%), Gaps = 29/327 (8%)
Query: 11 SHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSM-----FVTRTLRELKLLKF 65
+ +Q ++ + EG YG V A + T VA+KKI+ F +LRE+ +L
Sbjct: 295 NEFQKLNKINEGTYGIVYKARDEKTKEIVALKKIKMKEDRFEEEYGFPLTSLREINIL-L 353
Query: 66 FHSHENIISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQN--LSEDHIQYFVYQIL 123
+H I++V ++V VY+V E +E DL+ +++++ S ++ + Q+L
Sbjct: 354 SCNHPAIVNVKEVV--VGGKNDNDVYMVMEHLEHDLRGVMDRRKEPFSTSEVKCLMMQLL 411
Query: 124 RALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVAT 183
LK LH+ +IHRDLKPSNLL+N+ +LK+CDFG+AR S + T+ V T
Sbjct: 412 DGLKYLHTNWIIHRDLKPSNLLMNNCGELKICDFGMARQYGSPIKP-------YTQMVIT 464
Query: 184 RWYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPT-- 241
+WYR PE++L +EY+TA+D+WS GCI+AE++ KPLFPGK QL I VLG+P
Sbjct: 465 QWYRPPELLLGAKEYSTAVDMWSVGCIMAELLSQKPLFPGKSELDQLQKIFAVLGTPNEA 524
Query: 242 ----LEDFEQIKSKRAKEYISQLPMKKGIPWANVLNKEV-NPLAIDLLSKMLTFNPDKRI 296
F K+K + + L +K P + + ++ + DLL+ +LT +P+KR+
Sbjct: 525 IWPGFSSFPNAKAKFPTQPYNML--RKKFPAISFVGGQILSERGFDLLNSLLTLDPEKRL 582
Query: 297 SAVEALEHPYLATYHDP---DDEPDYP 320
+ +AL H + P D P YP
Sbjct: 583 TVEDALNHGWFHEVPLPKSKDFMPTYP 609
>At3g61160 [G] KOG0658 Glycogen synthase kinase-3
Length = 431
Score = 174 bits (440), Expect = 2e-43
Identities = 103/308 (33%), Positives = 167/308 (53%), Gaps = 24/308 (7%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTLRELKLLKFFHSHENI 72
Y+ ++G G++G V A T KVAIKK+ R + R L+ +++L H N+
Sbjct: 102 YRAEHVIGTGSFGVVFQAKCLETEEKVAIKKVLQDKR--YKNRELQIMRML----DHPNV 155
Query: 73 ISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQNLSEDH-----IQYFVYQILRALK 127
+ + T+ + LV E + + + H IQ + YQI RA+
Sbjct: 156 VELKHSFFSTTEKDELYLNLVLEYVPETIYRASRSYTKMNQHMPLIYIQLYTYQICRAMN 215
Query: 128 SLHSAQ-VIHRDLKPSNLLLNS-NCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRW 185
LH V HRD+KP NLL+N+ ++K+CDFG A+ L + + Y+ +R+
Sbjct: 216 YLHQVVGVCHRDIKPQNLLVNNVTHEVKICDFGSAKMLIPGEPN--------ISYICSRY 267
Query: 186 YRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDF 245
YRAPE++ EYT+A+D+WS GC++AE+ +G PLFPG+ QL I+++LG+P
Sbjct: 268 YRAPELIFGATEYTSAIDMWSVGCVMAELFLGHPLFPGETSVDQLVEIIKILGTPAR--- 324
Query: 246 EQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEHP 305
E+IK+ + + P K PW + ++V+P A+DL S++L ++P+ R +A+EA HP
Sbjct: 325 EEIKNMNPRYNDFKFPQIKAQPWHKIFRRQVSPEAMDLASRLLQYSPNLRCTALEACAHP 384
Query: 306 YLATYHDP 313
+ DP
Sbjct: 385 FFDDLRDP 392
>CE03811 [R] KOG0663 Protein kinase PITSLRE and related kinases
Length = 763
Score = 173 bits (439), Expect = 3e-43
Identities = 120/365 (32%), Positives = 198/365 (53%), Gaps = 20/365 (5%)
Query: 11 SHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQ-PFSRSMFVTRTLRELKLLKFFHSH 69
S Y +++++ EG YG V + T+ VA+K+ + + F LRE+ +L +H
Sbjct: 397 SEYVILNVIAEGTYGEVFRGKNTRTDEVVALKRFKMEKEKEGFPITALREINMLLKAGAH 456
Query: 70 ENIISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQ-----QNLSEDHIQYFVYQILR 124
ENI++V +I+ ++ K E VY+ E +E D++ +I++ Q + + Q+L
Sbjct: 457 ENIVNVKEILVGST--KTE-VYMAMEYVEHDVKSLIDKMRSRNQRFKTGQQKTLMSQLLS 513
Query: 125 ALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATR 184
++ +H ++HRDLK SNLL++ + LK+ DFGLAR + + M +T V T
Sbjct: 514 GIEHMHKLWILHRDLKTSNLLISHSGILKIADFGLAREYGEARDIEKRMK--LTPIVVTL 571
Query: 185 WYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLED 244
WYR+PE++L + Y+T +D+WS GCI+AE IM KP+F G +Q+ I +++G+PT +
Sbjct: 572 WYRSPELLLEPKTYSTPVDMWSIGCIMAEFIMMKPMFQGDSEPNQVHQIFQMMGTPTEQI 631
Query: 245 FEQIKSKRAKEYISQLPMKKG-IPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALE 303
+ IK + + P+K G + K VN DLL+ ML NP R++A EAL+
Sbjct: 632 WPDIKELKVWNMVEFPPVKPGQLRRIFKGEKLVNETGFDLLNGMLCLNPANRLTASEALQ 691
Query: 304 HPYLATYH---DPDDEPDYP---QLNL--EDNFWKIDNEARDKNEEDDIPLELLKKMLYG 355
H + + + P+D P YP +LN +N K EA +EE + L + +
Sbjct: 692 HDWFSEHPKAVPPEDLPVYPAKSELNAAPPENRRKNRLEALLADEEPERAALLRQFNVKA 751
Query: 356 EVMKP 360
E +KP
Sbjct: 752 EQLKP 756
>At2g30980 [G] KOG0658 Glycogen synthase kinase-3
Length = 412
Score = 173 bits (439), Expect = 3e-43
Identities = 106/309 (34%), Positives = 167/309 (53%), Gaps = 24/309 (7%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTLRELKLLKFFHSHENI 72
Y +VG G++G V A T VAIKK+ R REL+L++ H N+
Sbjct: 72 YMAERVVGTGSFGIVFQAKCLETGESVAIKKVLQDRRYKN-----RELQLMRLM-DHPNV 125
Query: 73 ISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQNLSED-----HIQYFVYQILRALK 127
+S+ T+ + LV E + L +++ S +++ + YQI R L
Sbjct: 126 VSLKHCFFSTTTRDELFLNLVMEYVPETLYRVLKHYTSSNQRMPIFYVKLYTYQIFRGLA 185
Query: 128 SLHSAQ-VIHRDLKPSNLLLNS-NCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRW 185
+H+A V HRD+KP NLL++ K+CDFG A+ L + + Y+ +R+
Sbjct: 186 YIHTAPGVCHRDVKPQNLLVDPLTHQCKLCDFGSAKVLVKGEAN--------ISYICSRY 237
Query: 186 YRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDF 245
YRAPE++ EYT+++DIWS GC+LAE+++G+PLFPG++ QL I++VLG+PT
Sbjct: 238 YRAPELIFGATEYTSSIDIWSAGCVLAELLLGQPLFPGENSVDQLVEIIKVLGTPTR--- 294
Query: 246 EQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEHP 305
E+I+ + P K PW V +K + P AIDL S++L ++P R +A+EA HP
Sbjct: 295 EEIRCMNPNYTDFRFPQIKAHPWHKVFHKRMPPEAIDLASRLLQYSPSLRCTALEACAHP 354
Query: 306 YLATYHDPD 314
+ +P+
Sbjct: 355 FFNELREPN 363
>Hs20986508 [T] KOG0665 Jun-N-terminal kinase (JNK)
Length = 277
Score = 173 bits (438), Expect = 4e-43
Identities = 106/275 (38%), Positives = 156/275 (56%), Gaps = 33/275 (12%)
Query: 95 ELMETDLQKIINQQNLSEDHIQYFVYQILRALKSLHSAQVIHRDLKPSNLLLNSNCDLKV 154
ELM+ +L ++I Q L + + Y +YQ+L +K LHSA +IHRDLKPSN+++ S+C LK+
Sbjct: 2 ELMDANLCQVI-QMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKI 60
Query: 155 CDFGLARCLASSDQSRENMVGFMTEYVATRWYRAPEIMLSFQEYTTAMDIWSCGCILAEM 214
DFGLAR +S MT YV TR+YRAPE++L Y +DIWS GCI+ EM
Sbjct: 61 LDFGLARTAGTS--------FMMTPYVVTRYYRAPEVILG-MGYKENVDIWSVGCIMGEM 111
Query: 215 IMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQIKSKRAKEYISQLPMKKGIPWANVL-- 272
+ K LFPG+DY Q ++E LG+P E ++++ + Y+ P G+ + +
Sbjct: 112 VRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQ-PTVRNYVENRPKYAGLTFPKLFPD 170
Query: 273 ---------NKEVNPLAIDLLSKMLTFNPDKRISAVEALEHPYLATYHDPDDEPDYPQLN 323
NK A DLLSKML +P KRIS +AL+HPY+ ++DP E + P
Sbjct: 171 SLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDP-AEVEAPPPQ 229
Query: 324 LEDNFWKIDNEARDKNEEDDIPLELLKKMLYGEVM 358
+ D + +E + +E K+++Y EVM
Sbjct: 230 IYDK----------QLDEREHTIEEWKELIYKEVM 254
>7303051 [UT] KOG0662 Cyclin-dependent kinase CDK5
Length = 294
Score = 173 bits (438), Expect = 4e-43
Identities = 112/298 (37%), Positives = 165/298 (54%), Gaps = 20/298 (6%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFV-TRTLRELKLLKFFHSHEN 71
Y ++ +GEG YGTV ++ T VA+K+++ V + LRE+ LLK H+N
Sbjct: 4 YDKMEKIGEGTYGTVFKGRNRDTMEIVALKRVRLDEDDEGVPSSALREICLLKEL-KHKN 62
Query: 72 IISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQNLSEDHI--QYFVYQILRALKSL 129
I+ ++D++ H + + LV E + DL+K + N D + F+ Q+LR L
Sbjct: 63 IVRLIDVL-----HSDKKLTLVFEHCDQDLKKYFDSLNGEIDMAVCRSFMLQLLRGLAFC 117
Query: 130 HSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRAP 189
HS V+HRDLKP NLL+N N +LK+ DFGLAR V + V T WYR P
Sbjct: 118 HSHNVLHRDLKPQNLLINKNGELKLADFGLARAFGIP-------VKCYSAEVVTLWYRPP 170
Query: 190 EIMLSFQEYTTAMDIWSCGCILAEMI-MGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQI 248
+++ + YTT++D+WS GCILAE+ G+PLFPG D QL I VLG+P + + +
Sbjct: 171 DVLFGAKLYTTSIDMWSAGCILAELADAGRPLFPGSDVLDQLMKIFRVLGTPNEDSWPGV 230
Query: 249 KSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEHPY 306
+Y++ LP I + L +N DLL K+L P++RISA A++HPY
Sbjct: 231 --SHLSDYVA-LPSFPAITSWSQLVPRLNSKGRDLLQKLLICRPNQRISAEAAMQHPY 285
>Hs4505649 [R] KOG0594 Protein kinase PCTAIRE and related kinases
Length = 523
Score = 172 bits (435), Expect = 9e-43
Identities = 108/297 (36%), Positives = 163/297 (54%), Gaps = 19/297 (6%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTLRELKLLKFFHSHENI 72
Y ++ +GEG Y TV K T VA+K+I+ +RE+ LLK H NI
Sbjct: 192 YIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKDL-KHANI 250
Query: 73 ISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQN--LSEDHIQYFVYQILRALKSLH 130
+++ DIV H +++ LV E ++ DL++ ++ +S +++ F+YQILR L H
Sbjct: 251 VTLHDIV-----HTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRGLAYCH 305
Query: 131 SAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRAPE 190
+V+HRDLKP NLL+N +LK+ DFGLAR + ++ N V T WYR P+
Sbjct: 306 RRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEV-------VTLWYRPPD 358
Query: 191 IMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQIKS 250
++L EY T +D+W GCI EM G+PLFPG +L +I +LG+P+ E + I S
Sbjct: 359 VLLGSSEYLTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISS 418
Query: 251 -KRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEHPY 306
+ K Y P K P N + ++ I+L+ K L + KR+SA EA++H Y
Sbjct: 419 NEEFKNY--NFPKYKPEPLINHAPR-LDSEGIELIRKFLQYESKKRVSAEEAMKHVY 472
>7297578 [T] KOG0661 MAPK related serine/threonine protein kinase
Length = 822
Score = 172 bits (435), Expect = 9e-43
Identities = 105/298 (35%), Positives = 168/298 (56%), Gaps = 18/298 (6%)
Query: 11 SHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTLRELKLLKFFHSHE 70
+ Y + +G+G YGTV K T KVAIK+++ S LRE+K LK SH
Sbjct: 2 NRYITLTQLGDGTYGTVVLGQRKDTGEKVAIKRMKRKYYSWEEAMNLREVKSLKKL-SHP 60
Query: 71 NIISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQN--LSEDHIQYFVYQILRALKS 128
NI+ + +++R + +Y V E M+ +L ++I ++ L E ++ ++Q+L L
Sbjct: 61 NIVKLKEVIREN-----DTLYFVFEYMKENLYQMIKDRDTHLPEPELKSILFQVLTGLAF 115
Query: 129 LHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRA 188
+H HRDLKP NLL + +K+ DFGLAR + S T+YV+TRWYRA
Sbjct: 116 MHRHGFFHRDLKPENLLCSGPDLIKIADFGLAREIRSRPP--------FTDYVSTRWYRA 167
Query: 189 PEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQI 248
PE++L Y + +D+W+ GCI+AE+ +PLFPG QL+ I VLG+P +D+
Sbjct: 168 PEVLLHSTNYGSTIDLWAMGCIMAELYTFRPLFPGSSEVDQLFKICSVLGTPDKDDWPD- 226
Query: 249 KSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEHPY 306
+ A + P +P ++V+++ + +DLL ML ++PDKR +A ++L++PY
Sbjct: 227 GYRLASMIHFRYPDCIKVPLSSVVSR-CSQNGLDLLEDMLAYDPDKRPTAQQSLKYPY 283
>At5g14640 [G] KOG0658 Glycogen synthase kinase-3
Length = 408
Score = 171 bits (433), Expect = 2e-42
Identities = 106/309 (34%), Positives = 168/309 (54%), Gaps = 26/309 (8%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTLRELKLLKFFHSHENI 72
Y +VG+G++G V A T VAIKK+ R + R L+ ++LL H N+
Sbjct: 74 YMAERIVGQGSFGIVFQAKCLETGETVAIKKVLQDKR--YKNRELQTMRLL----DHPNV 127
Query: 73 ISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQ-----QNLSEDHIQYFVYQILRALK 127
+S+ T+ + LV E + + ++ Q + +++ + YQI RAL
Sbjct: 128 VSLKHCFFSTTEKDELYLNLVLEYVPETVYRVSKHYSRANQRMPIIYVKLYTYQICRALA 187
Query: 128 SLHSAQ-VIHRDLKPSNLLLNSNC-DLKVCDFGLARCLASSDQSRENMVGFMTEYVATRW 185
+H V HRD+KP NLL+N + +K+CDFG A+ L + + Y+ +R+
Sbjct: 188 YIHGGVGVCHRDIKPQNLLVNPHTHQVKLCDFGSAKVLVKGEPN--------ISYICSRY 239
Query: 186 YRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDF 245
YRAPE++ EYTT +DIWS GC+LAE+++G+PLFPG+ QL I++VLG+PT
Sbjct: 240 YRAPELIFGATEYTTTIDIWSAGCVLAELLLGQPLFPGESGVDQLVEIIKVLGTPTR--- 296
Query: 246 EQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEHP 305
E+IK + P K PW + +K P A+DL+S++L ++P+ R +A A+ HP
Sbjct: 297 EEIKCMNPNYTEFKFPQIKAHPWHKIFHKRTPPEAVDLVSRLLQYSPNLRSTA--AIVHP 354
Query: 306 YLATYHDPD 314
+ DP+
Sbjct: 355 FFDELRDPN 363
>Hs4507281 [R] KOG0593 Predicted protein kinase KKIAMRE
Length = 1030
Score = 171 bits (432), Expect = 2e-42
Identities = 107/322 (33%), Positives = 176/322 (54%), Gaps = 34/322 (10%)
Query: 8 DIPSHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRT-LRELKLLKFF 66
++ + ++++ +VGEGAYG V HK T+ VAIKK + + V T LRELK+L+
Sbjct: 8 NVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTL 67
Query: 67 HSHENIISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQ--NLSEDHIQYFVYQILR 124
ENI+ + + R +YLV E +E ++ +++ + + + ++ ++YQ+++
Sbjct: 68 -KQENIVELKEAFRRRG-----KLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIK 121
Query: 125 ALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATR 184
A+ H ++HRD+KP NLL++ N LK+CDFG AR L+ + + TEYVATR
Sbjct: 122 AIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNAN------YTEYVATR 175
Query: 185 WYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLED 244
WYR+PE++L Y ++D+WS GCIL E+ G+PLFPG+ QL+ I +VLG
Sbjct: 176 WYRSPELLLG-APYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLG------ 228
Query: 245 FEQIKSKRAKEYISQLPMKKGIPWANVLNKE---------VNPLAIDLLSKMLTFNPDKR 295
+ S++ K + S P G+ + V + + +N + +DL+ +L +P R
Sbjct: 229 --PLPSEQMKLFYSN-PRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADR 285
Query: 296 ISAVEALEHPYLATYHDPDDEP 317
+ L HP T D P
Sbjct: 286 YLTEQCLNHPTFQTQRLLDRSP 307
>At4g18710 [G] KOG0658 Glycogen synthase kinase-3
Length = 380
Score = 171 bits (432), Expect = 2e-42
Identities = 105/309 (33%), Positives = 168/309 (53%), Gaps = 24/309 (7%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTLRELKLLKFFHSHENI 72
Y +VG G++G V A T VAIKK+ R REL+L++ H N+
Sbjct: 40 YMAERVVGTGSFGIVFQAKCLETGETVAIKKVLQDRRYKN-----RELQLMRVM-DHPNV 93
Query: 73 ISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQ-----QNLSEDHIQYFVYQILRALK 127
+ + T+ + LV E + L +++ Q + +++ ++YQI R L
Sbjct: 94 VCLKHCFFSTTSKDELFLNLVMEYVPESLYRVLKHYSSANQRMPLVYVKLYMYQIFRGLA 153
Query: 128 SLHS-AQVIHRDLKPSNLLLNS-NCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRW 185
+H+ A V HRDLKP NLL++ +K+CDFG A+ L + + Y+ +R+
Sbjct: 154 YIHNVAGVCHRDLKPQNLLVDPLTHQVKICDFGSAKQLVKGEAN--------ISYICSRF 205
Query: 186 YRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDF 245
YRAPE++ EYTT++DIWS GC+LAE+++G+PLFPG++ QL I++VLG+PT
Sbjct: 206 YRAPELIFGATEYTTSIDIWSAGCVLAELLLGQPLFPGENAVDQLVEIIKVLGTPTR--- 262
Query: 246 EQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEHP 305
E+I+ + P K PW + +K + P AID S++L ++P R +A+EA HP
Sbjct: 263 EEIRCMNPHYTDFRFPQIKAHPWHKIFHKRMPPEAIDFASRLLQYSPSLRCTALEACAHP 322
Query: 306 YLATYHDPD 314
+ +P+
Sbjct: 323 FFDELREPN 331
>At4g00720 [G] KOG0658 Glycogen synthase kinase-3
Length = 472
Score = 171 bits (432), Expect = 2e-42
Identities = 104/309 (33%), Positives = 164/309 (52%), Gaps = 24/309 (7%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTLRELKLLKFFHSHENI 72
Y +VG G++G V A T +VAIKK+ R REL++++ H N+
Sbjct: 138 YMAQRVVGTGSFGVVFQAKCLETGEQVAIKKVLQDKRYKN-----RELQIMRL-QDHPNV 191
Query: 73 ISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQNLSEDH-----IQYFVYQILRALK 127
+ + T+ + LV E + + + H +Q + YQI RAL
Sbjct: 192 VRLRHSFFSTTDKDELYLNLVLEYVPETVYRASKHYTKMNQHMPIIFVQLYTYQICRALN 251
Query: 128 SLHSAQ-VIHRDLKPSNLLLNSNC-DLKVCDFGLARCLASSDQSRENMVGFMTEYVATRW 185
LH V HRD+KP NLL+N LK+CDFG A+ L + + Y+ +R+
Sbjct: 252 YLHRVVGVCHRDIKPQNLLVNPQTHQLKICDFGSAKMLVPGEPN--------ISYICSRY 303
Query: 186 YRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDF 245
YRAPE++ EYT A+D+WS GC++AE+++G+PLFPG+ QL I+++LG+PT
Sbjct: 304 YRAPELIFGATEYTNAIDMWSGGCVMAELLLGQPLFPGESGIDQLVEIIKILGTPTR--- 360
Query: 246 EQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEHP 305
E+I+ + P K PW + +K + P A+DL+S++L ++P+ R +A+EA HP
Sbjct: 361 EEIRCMNPNYTEFKFPQIKAHPWHKIFHKRMPPEAVDLVSRLLQYSPNLRCTALEACAHP 420
Query: 306 YLATYHDPD 314
+ DP+
Sbjct: 421 FFDDLRDPN 429
>At1g06390 [G] KOG0658 Glycogen synthase kinase-3
Length = 407
Score = 171 bits (432), Expect = 2e-42
Identities = 106/309 (34%), Positives = 166/309 (53%), Gaps = 24/309 (7%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTLRELKLLKFFHSHENI 72
Y +VG G++G V A T VAIKK+ R REL+L++ H N+
Sbjct: 70 YMAERVVGTGSFGIVFQAKCLETGESVAIKKVLQDRRYKN-----RELQLMRPM-DHPNV 123
Query: 73 ISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQNLSED-----HIQYFVYQILRALK 127
IS+ T+ + LV E + L +++ S +++ + YQI R L
Sbjct: 124 ISLKHCFFSTTSRDELFLNLVMEYVPETLYRVLRHYTSSNQRMPIFYVKLYTYQIFRGLA 183
Query: 128 SLHSAQ-VIHRDLKPSNLLLNS-NCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRW 185
+H+ V HRD+KP NLL++ +K+CDFG A+ L + + Y+ +R+
Sbjct: 184 YIHTVPGVCHRDVKPQNLLVDPLTHQVKLCDFGSAKVLVKGEPN--------ISYICSRY 235
Query: 186 YRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDF 245
YRAPE++ EYT ++DIWS GC+LAE+++G+PLFPG++ QL I++VLG+PT
Sbjct: 236 YRAPELIFGATEYTASIDIWSAGCVLAELLLGQPLFPGENSVDQLVEIIKVLGTPTR--- 292
Query: 246 EQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEHP 305
E+I+ + P K PW V +K + P AIDL S++L ++P R +A+EA HP
Sbjct: 293 EEIRCMNPNYTDFRFPQIKAHPWHKVFHKRMPPEAIDLASRLLQYSPSLRCTALEACAHP 352
Query: 306 YLATYHDPD 314
+ +P+
Sbjct: 353 FFNELREPN 361
>At1g73690 [DKL] KOG0659 Cdk activating kinase (CAK)/RNA polymerase II
transcription initiation/nucleotide excision repair
factor TFIIH/TFIIK kinase subunit CDK7
Length = 398
Score = 170 bits (431), Expect = 3e-42
Identities = 111/316 (35%), Positives = 163/316 (51%), Gaps = 20/316 (6%)
Query: 9 IPSHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRT-LRELKLLKFFH 67
+ Y +++G+G YG V A VAIKKI+ V T LRE+KLLK
Sbjct: 7 VADRYLKREVLGQGTYGVVFKATDTKNGETVAIKKIRLGKEKEGVNVTALREIKLLKEL- 65
Query: 68 SHENIISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQNL--SEDHIQYFVYQILRA 125
H +II ++D HK E +++V E METDL+ +I +NL S ++ ++ IL+
Sbjct: 66 KHPHIIELIDAFP----HK-ENLHIVFEFMETDLEAVIRDRNLYLSPGDVKSYLQMILKG 120
Query: 126 LKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRW 185
L+ H V+HRD+KP+NLL+ N LK+ DFGLAR S + T V RW
Sbjct: 121 LEYCHGKWVLHRDMKPNNLLIGPNGQLKLADFGLARIFGSPGRK-------FTHQVFARW 173
Query: 186 YRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDF 245
YRAPE++ ++Y A+D+W+ GCI AE+++ +P G QL I G+P + +
Sbjct: 174 YRAPELLFGAKQYDGAVDVWAAGCIFAELLLRRPFLQGNSDIDQLSKIFAAFGTPKADQW 233
Query: 246 EQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEHP 305
+ +P P L V+ A+DLLSKM T++P RIS +AL+H
Sbjct: 234 PDMICLPDYVEYQFVP----APSLRSLLPTVSEDALDLLSKMFTYDPKSRISIQQALKHR 289
Query: 306 YLATYHDPDDEPDYPQ 321
Y + P D P+
Sbjct: 290 YFTSAPSPTDPLKLPR 305
>At1g20930 [R] KOG0594 Protein kinase PCTAIRE and related kinases
Length = 315
Score = 170 bits (431), Expect = 3e-42
Identities = 110/318 (34%), Positives = 165/318 (51%), Gaps = 26/318 (8%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVT-RTLRELKLLKFFHSHEN 71
++ ++ VGEG YG V A K T VA+KK + V TLRE+ +L+ +
Sbjct: 16 FEKLEKVGEGTYGKVYRAREKATGMIVALKKTRLHEDEEGVPPTTLREISILRMLARDPH 75
Query: 72 IISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQ-----QNLSEDHIQYFVYQILRAL 126
I+ ++D+ + + +YLV E ++TDL+K I QN+ ++ ++ +YQ+ + +
Sbjct: 76 IVRLMDVKQGINKEGKTVLYLVFEYVDTDLKKFIRSFRQAGQNIPQNTVKCLMYQLCKGM 135
Query: 127 KSLHSAQVIHRDLKPSNLLLN-SNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRW 185
H V+HRDLKP NLL++ LK+ D GLAR + T + T W
Sbjct: 136 AFCHGHGVLHRDLKPHNLLMDRKTMTLKIADLGLARAFTLPMKK-------YTHEILTLW 188
Query: 186 YRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDF 245
YRAPE++L Y+T +D+WS GCI AE++ + +F G QL I +LG+P E +
Sbjct: 189 YRAPEVLLGATHYSTGVDMWSVGCIFAELVTKQAIFAGDSELQQLLRIFRLLGTPNEEVW 248
Query: 246 EQI-KSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEH 304
+ K K EY P+ N ++ +DLLSKML + P KRISA +A+EH
Sbjct: 249 PGVSKLKDWHEYPQWKPLSLSTAVPN-----LDEAGLDLLSKMLEYEPAKRISAKKAMEH 303
Query: 305 PYLATYHDPDDEPDYPQL 322
PY DD PD L
Sbjct: 304 PYF------DDLPDKSSL 315
>7303804 [R] KOG0663 Protein kinase PITSLRE and related kinases
Length = 387
Score = 170 bits (430), Expect = 3e-42
Identities = 110/319 (34%), Positives = 176/319 (54%), Gaps = 23/319 (7%)
Query: 11 SHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQ-PFSRSMFVTRTLRELKLLKFFHSH 69
S ++ ++ VGEG+YG V A +N VA+KK++ + LRE+ +LK H H
Sbjct: 51 SEFEKLNRVGEGSYGIVYRARDTRSNEIVALKKVRMDQEKDGLPISGLREIMILKQCH-H 109
Query: 70 ENIISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQ--QNLSEDHIQYFVYQILRALK 127
ENI+ + ++V S ++++LV + E DL +++ Q +E ++ Q+L+ALK
Sbjct: 110 ENIVRLREVVVGKS---LDSIFLVMDFCEQDLASVLDNMSQPFTESEVKCITLQVLKALK 166
Query: 128 SLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYR 187
LHS +IHRDLK SNLL+ +KV DFGLAR ++ + MT + T WYR
Sbjct: 167 YLHSRFMIHRDLKVSNLLMTDKGCIKVADFGLARMFSNPPKP-------MTPQMVTLWYR 219
Query: 188 APEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQ 247
APE++L + +TTA+D+W+ GCIL E+++GKPL PG QL +I+++LG+P+ +
Sbjct: 220 APELLLGCRTHTTAVDMWAFGCILGELLLGKPLLPGNSEIAQLDMIIDLLGAPSESIWPG 279
Query: 248 IKSKRAKE--YISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEHP 305
A + +SQ P P +++ + +LL+ + +NP R +A E L+
Sbjct: 280 FADLPAVQNFTLSQQPYNNLTPKFHMIGQS----GRNLLNILFIYNPKTRATAEECLKSK 335
Query: 306 YLA---TYHDPDDEPDYPQ 321
Y DP P +PQ
Sbjct: 336 YFVDPPQACDPGMMPTFPQ 354
>Hs4505569 [R] KOG0593 Predicted protein kinase KKIAMRE
Length = 493
Score = 169 bits (429), Expect = 4e-42
Identities = 107/307 (34%), Positives = 167/307 (53%), Gaps = 37/307 (12%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTR-TLRELKLLKFFHSHEN 71
Y+ + LVGEG+YG V +K T VAIKK V + +RE+KLLK HEN
Sbjct: 4 YENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLR-HEN 62
Query: 72 IISVLDIVRPTSWHKFEAVYLVQELME----TDLQKIINQQNLSEDHIQYFVYQILRALK 127
++++L++ + K + YLV E ++ DL+ N L +Q +++QI+ +
Sbjct: 63 LVNLLEVCK-----KKKRWYLVFEFVDHTILDDLELFPN--GLDYQVVQKYLFQIINGIG 115
Query: 128 SLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYR 187
HS +IHRD+KP N+L++ + +K+CDFG AR LA+ + T+YVATRWYR
Sbjct: 116 FCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGE-------VYTDYVATRWYR 168
Query: 188 APEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQ 247
APE+++ +Y A+D+W+ GC++ EM MG+PLFPG QL+ I+ LG+
Sbjct: 169 APELLVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGN-------- 220
Query: 248 IKSKRAKEYISQLPMKKGIPWANVLNKE--------VNPLAIDLLSKMLTFNPDKRISAV 299
R +E ++ P+ G+ + +E ++ + IDL K L +PDKR
Sbjct: 221 -LIPRHQELFNKNPVFAGVRLPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCA 279
Query: 300 EALEHPY 306
E L H +
Sbjct: 280 ELLHHDF 286
>Hs5453860 [R] KOG0594 Protein kinase PCTAIRE and related kinases
Length = 496
Score = 169 bits (428), Expect = 6e-42
Identities = 106/307 (34%), Positives = 163/307 (52%), Gaps = 39/307 (12%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTLRELKLLKFFHSHENI 72
Y +D +GEG Y TV K T+ VA+K+I+ +RE+ LLK H NI
Sbjct: 165 YIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDL-KHANI 223
Query: 73 ISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQN--LSEDHIQYFVYQILRALKSLH 130
+++ DI+ H +++ LV E ++ DL++ ++ ++ +++ F++Q+LR L H
Sbjct: 224 VTLHDII-----HTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCH 278
Query: 131 SAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRAPE 190
+V+HRDLKP NLL+N +LK+ DFGLAR + ++ N V T WYR P+
Sbjct: 279 RQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEV-------VTLWYRPPD 331
Query: 191 IMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQIKS 250
I+L +Y+T +D+W GCI EM G+PLFPG QL I +LG+PT E + I S
Sbjct: 332 ILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILS 391
Query: 251 K-----------RAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAV 299
RA+ +S P ++ DLL+K+L F RISA
Sbjct: 392 NEEFKTYNYPKYRAEALLSHAP-------------RLDSDGADLLTKLLQFEGRNRISAE 438
Query: 300 EALEHPY 306
+A++HP+
Sbjct: 439 DAMKHPF 445
>Hs15011928 [R] KOG0594 Protein kinase PCTAIRE and related kinases
Length = 448
Score = 169 bits (428), Expect = 6e-42
Identities = 106/307 (34%), Positives = 163/307 (52%), Gaps = 39/307 (12%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTLRELKLLKFFHSHENI 72
Y +D +GEG Y TV K T+ VA+K+I+ +RE+ LLK H NI
Sbjct: 117 YIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDL-KHANI 175
Query: 73 ISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQN--LSEDHIQYFVYQILRALKSLH 130
+++ DI+ H +++ LV E ++ DL++ ++ ++ +++ F++Q+LR L H
Sbjct: 176 VTLHDII-----HTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCH 230
Query: 131 SAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRAPE 190
+V+HRDLKP NLL+N +LK+ DFGLAR + ++ N V T WYR P+
Sbjct: 231 RQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEV-------VTLWYRPPD 283
Query: 191 IMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQIKS 250
I+L +Y+T +D+W GCI EM G+PLFPG QL I +LG+PT E + I S
Sbjct: 284 ILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILS 343
Query: 251 K-----------RAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAV 299
RA+ +S P ++ DLL+K+L F RISA
Sbjct: 344 NEEFKTYNYPKYRAEALLSHAP-------------RLDSDGADLLTKLLQFEGRNRISAE 390
Query: 300 EALEHPY 306
+A++HP+
Sbjct: 391 DAMKHPF 397
>At5g64960 [D] KOG0600 Cdc2-related protein kinase
Length = 513
Score = 169 bits (428), Expect = 6e-42
Identities = 113/331 (34%), Positives = 176/331 (53%), Gaps = 25/331 (7%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFS-RSMFVTRTLRELKLLKFFHSHEN 71
++ ++ +GEG YG V A T VA+KKI+ + R F +RE+K+LK H HEN
Sbjct: 26 FEKLEQIGEGTYGQVYMAKEIKTGEIVALKKIRMDNEREGFPITAIREIKILKKLH-HEN 84
Query: 72 IISVLDIV-----------RPTSWHKFEAVYLVQELMETDLQKIINQQNL--SEDHIQYF 118
+I + +IV +P + +Y+V E M+ DL + ++ L + I+ +
Sbjct: 85 VIHLKEIVTSPGRDRDDQGKPDNNKYKGGIYMVFEYMDHDLTGLADRPGLRFTVPQIKCY 144
Query: 119 VYQILRALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMT 178
+ Q+L L H QV+HRD+K SNLL+++ +LK+ DFGLAR + + G +T
Sbjct: 145 MKQLLTGLHYCHVNQVLHRDIKGSNLLIDNEGNLKLADFGLARSYS------HDHTGNLT 198
Query: 179 EYVATRWYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLG 238
V T WYR PE++L +Y A+D+WS GCI AE++ GKP+ PGK + QL I E+ G
Sbjct: 199 NRVITLWYRPPELLLGATKYGPAIDMWSVGCIFAELLNGKPILPGKTENEQLNKIYELCG 258
Query: 239 SPTLEDFEQI-KSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRIS 297
SP ++ + K + S P+K+ + + + + A++LL KML +P +RI
Sbjct: 259 SPDESNWPGVSKMPWYNQMKSSRPLKRRV---REIYRHFDRHALELLEKMLVLDPSQRIC 315
Query: 298 AVEALEHPYLATYHDPDDEPDYPQLNLEDNF 328
A +AL+ Y T P D P F
Sbjct: 316 AKDALDAEYFWTDPLPCDPKSLPTYESSHEF 346
>At1g57870 [G] KOG0658 Glycogen synthase kinase-3
Length = 420
Score = 169 bits (427), Expect = 8e-42
Identities = 103/304 (33%), Positives = 164/304 (53%), Gaps = 24/304 (7%)
Query: 18 LVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTLRELKLLKFFHSHENIISVLD 77
+VG G++G V A + T VAIKK+ R + R L+ +++L H N++ +
Sbjct: 87 VVGTGSFGMVFQAKCRETGEVVAIKKVLQDKR--YKNRELQIMQML----DHPNVVCLKH 140
Query: 78 IVRPTSWHKFEAVYLVQELMETDLQKIINQQNLSED-----HIQYFVYQILRALKSLHSA 132
+ ++ + LV E + + + + +++ + YQI R L LH+
Sbjct: 141 SFYSRTENEEVYLNLVLEFVPETVNRTARSYSRMNQLMPLIYVKLYTYQICRGLAYLHNC 200
Query: 133 -QVIHRDLKPSNLLLNSNC-DLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRAPE 190
+ HRD+KP NLL+N + LK+CDFG A+ L + + Y+ +R+YRAPE
Sbjct: 201 CGLCHRDIKPQNLLVNPHTHQLKICDFGSAKVLVKGEPN--------ISYICSRYYRAPE 252
Query: 191 IMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQIKS 250
++ EYTTA+DIWS GC++AE+++G+PLFPG+ QL I++VLG+PT E+IK
Sbjct: 253 LIFGATEYTTAIDIWSTGCVMAELLLGQPLFPGESGVDQLVEIIKVLGTPTR---EEIKC 309
Query: 251 KRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEHPYLATY 310
+ P K PW V K + P A+DLL + ++P+ R +AVEA HP+
Sbjct: 310 MNPNYTEFKFPQIKPHPWHKVFQKRLPPEAVDLLCRFFQYSPNLRCTAVEACIHPFFDEL 369
Query: 311 HDPD 314
DP+
Sbjct: 370 RDPN 373
>At1g09840 [G] KOG0658 Glycogen synthase kinase-3
Length = 421
Score = 169 bits (427), Expect = 8e-42
Identities = 102/304 (33%), Positives = 167/304 (54%), Gaps = 24/304 (7%)
Query: 18 LVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTLRELKLLKFFHSHENIISVLD 77
+VG G++G V A + T VAIKK+ R + R L+ +++L H N +++
Sbjct: 88 VVGTGSFGMVFQAKCRETGEVVAIKKVLQDKR--YKNRELQIMQML----DHPNAVALKH 141
Query: 78 IVRPTSWHKFEAVYLVQELMETDLQKIINQQNLSED-----HIQYFVYQILRALKSLHSA 132
+ ++ + LV E + + ++ + + +++ + YQI RAL +H++
Sbjct: 142 SFFSRTDNEEVYLNLVLEFVPETVNRVARSYSRTNQLMPLIYVKLYTYQICRALAYIHNS 201
Query: 133 -QVIHRDLKPSNLLLNSNC-DLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRAPE 190
+ HRD+KP NLL+N + LK+CDFG A+ L + + Y+ +R+YRAPE
Sbjct: 202 FGLCHRDIKPQNLLVNPHTHQLKICDFGSAKVLVKGEPN--------VSYICSRYYRAPE 253
Query: 191 IMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQIKS 250
++ EYTTA+DIWS GC++AE+++G+PLFPG+ QL I++VLG+PT E+IK
Sbjct: 254 LIFGASEYTTAIDIWSTGCVMAELLLGQPLFPGESGVDQLVEIIKVLGTPTR---EEIKC 310
Query: 251 KRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEHPYLATY 310
+ P K PW V K + P A+DLL + ++P+ R +A+EA HP
Sbjct: 311 MNPNYTEFKFPQIKPHPWHKVFQKRLPPEAVDLLCRFFQYSPNLRCTALEACIHPLFDEL 370
Query: 311 HDPD 314
DP+
Sbjct: 371 RDPN 374
>At5g10270 [D] KOG0600 Cdc2-related protein kinase
Length = 505
Score = 168 bits (426), Expect = 1e-41
Identities = 118/351 (33%), Positives = 180/351 (50%), Gaps = 38/351 (10%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFS-RSMFVTRTLRELKLLKFFHSHEN 71
++ ++ +GEG YG V A T VA+KKI+ + R F +RE+K+LK H HEN
Sbjct: 26 FEKLEQIGEGTYGQVYMAKEIKTGEIVALKKIRMDNEREGFPITAIREIKILKKLH-HEN 84
Query: 72 IISVLDIV-----------RPTSWHKFEAVYLVQELMETDLQKIINQQNL--SEDHIQYF 118
+I + +IV +P + +Y+V E M+ DL + ++ L + I+ +
Sbjct: 85 VIQLKEIVTSPGRDRDDQGKPDNNKYKGGIYMVFEYMDHDLTGLADRPGLRFTVPQIKCY 144
Query: 119 VYQILRALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMT 178
+ Q+L L H QV+HRD+K SNLL+++ +LK+ DFGLAR + + G +T
Sbjct: 145 MKQLLTGLHYCHVNQVLHRDIKGSNLLIDNEGNLKLADFGLARSYS------HDHTGNLT 198
Query: 179 EYVATRWYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLG 238
V T WYR PE++L +Y A+D+WS GCI AE++ KP+ PGK+ QL I E+ G
Sbjct: 199 NRVITLWYRPPELLLGATKYGPAIDMWSVGCIFAELLHAKPILPGKNEQEQLNKIFELCG 258
Query: 239 SPTLEDFEQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPL-------AIDLLSKMLTFN 291
SP ++ +S++P A L + V A++LL KML +
Sbjct: 259 SP---------DEKLWPGVSKMPWFNNFKPARPLKRRVREFFRHFDRHALELLEKMLVLD 309
Query: 292 PDKRISAVEALEHPYLATYHDPDDEPDYPQLNLEDNF-WKIDNEARDKNEE 341
P +RISA +AL+ Y T P D P F K + + +NEE
Sbjct: 310 PAQRISAKDALDAEYFWTDPLPCDPKSLPTYESSHEFQTKKKRQQQRQNEE 360
>At2g38620 [R] KOG0594 Protein kinase PCTAIRE and related kinases
Length = 311
Score = 168 bits (426), Expect = 1e-41
Identities = 110/313 (35%), Positives = 162/313 (51%), Gaps = 33/313 (10%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQ-PFSRSMFVTRTLRELKLLKFFHSHEN 71
Y+ ++ VGEG YG V A+ K T VA+KK + LRE+ LL+
Sbjct: 4 YEKLEKVGEGTYGKVYKAMEKTTGKLVALKKTRLEMDEEGIPPTALREISLLQMLSQSIY 63
Query: 72 IISVLDIVR-------PTSWHKFEAVYLVQELMETDLQKII-------NQQNLSEDHIQY 117
I+ +L + S +YLV E ++TDL+K I N + L +Q
Sbjct: 64 IVRLLCVEHVIQSKDSTVSHSPKSNLYLVFEYLDTDLKKFIDSHRKGSNPRPLEASLVQR 123
Query: 118 FVYQILRALKSLHSAQVIHRDLKPSNLLLNSNCD-LKVCDFGLARCLASSDQSRENMVGF 176
F++Q+ + + HS V+HRDLKP NLLL+ + LK+ D GL+R ++
Sbjct: 124 FMFQLFKGVAHCHSHGVLHRDLKPQNLLLDKDKGILKIADLGLSRAFTVPLKA------- 176
Query: 177 MTEYVATRWYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEV 236
T + T WYRAPE++L Y+TA+DIWS GCI AEMI + LFPG QL I +
Sbjct: 177 YTHEIVTLWYRAPEVLLGSTHYSTAVDIWSVGCIFAEMIRRQALFPGDSEFQQLLHIFRL 236
Query: 237 LGSPTLEDFEQIKSKRAKEYISQ---LPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPD 293
LG+PT + + + + R + + + +P ++P IDLL++ML +NP
Sbjct: 237 LGTPTEQQWPGVMALRDWHVYPKWEPQDLSRAVP-------SLSPEGIDLLTQMLKYNPA 289
Query: 294 KRISAVEALEHPY 306
+RISA AL+HPY
Sbjct: 290 ERISAKAALDHPY 302
>7297680 [R] KOG0594 Protein kinase PCTAIRE and related kinases
Length = 297
Score = 168 bits (425), Expect = 1e-41
Identities = 106/299 (35%), Positives = 163/299 (54%), Gaps = 21/299 (7%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRT-LRELKLLKFFHSHEN 71
++ ++ +GEG YG V ++ T VA+KKI+ S V T +RE+ LLK HEN
Sbjct: 4 FEKIEKIGEGTYGVVYKGRNRLTGQIVAMKKIRLESDDEGVPSTAIREISLLKEL-KHEN 62
Query: 72 IISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQ----QNLSEDHIQYFVYQILRALK 127
I+ + D++ + +YL+ E + DL+K ++ +++ + ++ ++YQI A+
Sbjct: 63 IVCLEDVLMEEN-----RIYLIFEFLSMDLKKYMDSLPVDKHMESELVRSYLYQITSAIL 117
Query: 128 SLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYR 187
H +V+HRDLKP NLL++ + +KV DFGL R V T + T WYR
Sbjct: 118 FCHRRRVLHRDLKPQNLLIDKSGLIKVADFGLGRSFGIP-------VRIYTHEIVTLWYR 170
Query: 188 APEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQ 247
APE++L Y+ +DIWS GCI AEM KPLF G QL+ + +L +PT + +
Sbjct: 171 APEVLLGSPRYSCPVDIWSIGCIFAEMATRKPLFQGDSEIDQLFRMFRILKTPTEDIWPG 230
Query: 248 IKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEHPY 306
+ S +Y + P N L K ++ IDL+ KML ++P RISA + LEHPY
Sbjct: 231 VTS--LPDYKNTFPCWSTNQLTNQL-KNLDANGIDLIQKMLIYDPVHRISAKDILEHPY 286
>At4g13020 [T] KOG0661 MAPK related serine/threonine protein kinase
Length = 443
Score = 167 bits (424), Expect = 2e-41
Identities = 120/338 (35%), Positives = 181/338 (53%), Gaps = 32/338 (9%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTLRELKLLKFFHSHENI 72
Y++++ +G+G G+V A++ T VA+KK++ LRE+K L+ + H +I
Sbjct: 12 YKILEELGDGTCGSVYKAVNLETYEVVAVKKMKRKFYYWEECVNLREVKALRKLN-HPHI 70
Query: 73 ISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQN--LSEDHIQYFVYQILRALKSLH 130
I + +IVR + ++ + E M+ +L I+ ++ SE I+ F+ Q+L+ L +H
Sbjct: 71 IKLKEIVR-----EHNELFFIFECMDHNLYHIMKERERPFSEGEIRSFMSQMLQGLAHMH 125
Query: 131 SAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRAPE 190
HRDLKP NLL+ +N LK+ DFGLAR +AS TEYV+TRWYRAPE
Sbjct: 126 KNGYFHRDLKPENLLVTNNI-LKIADFGLAREVASMPP--------YTEYVSTRWYRAPE 176
Query: 191 IMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQIKS 250
++L YT A+D+W+ G ILAE+ PLFPG+ QL+ I VLG P F + KS
Sbjct: 177 VLLQSSLYTPAVDMWAVGAILAELYALTPLFPGESEIDQLYKICCVLGKPDWTTFPEAKS 236
Query: 251 KRAKEYISQLPMKKGIPWANVLNKEVN--PLAIDLLSKMLTFNPDKRISAVEALEHPYL- 307
IS P + + N P AIDL++++ +++P KR +A EAL HP+
Sbjct: 237 ISRIMSISHTE----FPQTRIADLLPNAAPEAIDLINRLCSWDPLKRPTADEALNHPFFS 292
Query: 308 ----ATYHDPDDEPDYPQL----NLEDNFWKIDNEARD 337
A+Y D E + NLE N W + E +
Sbjct: 293 MATQASYPIHDLELRLDNMAALPNLELNLWDFNREPEE 330
>CE29073 [R] KOG0594 Protein kinase PCTAIRE and related kinases
Length = 700
Score = 167 bits (423), Expect = 2e-41
Identities = 105/304 (34%), Positives = 163/304 (53%), Gaps = 27/304 (8%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTLRELKLLKFFHSHENI 72
Y+ +D +GEG Y TV TN VA+K+I+ +RE+ LL+ H N+
Sbjct: 361 YEKLDKLGEGTYATVFRGRSILTNKFVALKEIRLEQEEGAPCTAIREVSLLRNLR-HANV 419
Query: 73 ISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQN--LSEDHIQYFVYQILRALKSLH 130
+++ DI+ H + LV E ++ DL++ ++ N + ++I+ F+YQ+LR L H
Sbjct: 420 VTLHDII-----HTDRLLTLVFEYVDRDLKQYMDSCNNAMQMNNIRLFLYQLLRGLAYCH 474
Query: 131 SAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRAPE 190
+V+HRDLKP NLL+ + +LK+ DFGLAR + ++ N V T WYR P+
Sbjct: 475 QRRVLHRDLKPQNLLITAKGELKLADFGLARAKSVPTKTYSNEV-------VTLWYRPPD 527
Query: 191 IMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQIKS 250
++L +Y+T +D+W GCIL EMI G+ LFPG QL +I LGSP + I
Sbjct: 528 VLLGSTDYSTHIDMWGVGCILFEMIAGRALFPGGTPTEQLGLIFRTLGSPRPDRHPTICE 587
Query: 251 K-----RAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEHP 305
K A + + P+ + IP ++ +LL K L + R+SA EA++HP
Sbjct: 588 KPTFYPYANRHYNPDPLCRQIP-------RIDAHGFELLMKFLQYEGKDRVSAAEAVKHP 640
Query: 306 YLAT 309
+L T
Sbjct: 641 FLRT 644
>CE06779 [R] KOG0594 Protein kinase PCTAIRE and related kinases
Length = 577
Score = 167 bits (423), Expect = 2e-41
Identities = 105/304 (34%), Positives = 163/304 (53%), Gaps = 27/304 (8%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTLRELKLLKFFHSHENI 72
Y+ +D +GEG Y TV TN VA+K+I+ +RE+ LL+ H N+
Sbjct: 238 YEKLDKLGEGTYATVFRGRSILTNKFVALKEIRLEQEEGAPCTAIREVSLLRNLR-HANV 296
Query: 73 ISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQN--LSEDHIQYFVYQILRALKSLH 130
+++ DI+ H + LV E ++ DL++ ++ N + ++I+ F+YQ+LR L H
Sbjct: 297 VTLHDII-----HTDRLLTLVFEYVDRDLKQYMDSCNNAMQMNNIRLFLYQLLRGLAYCH 351
Query: 131 SAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRAPE 190
+V+HRDLKP NLL+ + +LK+ DFGLAR + ++ N V T WYR P+
Sbjct: 352 QRRVLHRDLKPQNLLITAKGELKLADFGLARAKSVPTKTYSNEV-------VTLWYRPPD 404
Query: 191 IMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQIKS 250
++L +Y+T +D+W GCIL EMI G+ LFPG QL +I LGSP + I
Sbjct: 405 VLLGSTDYSTHIDMWGVGCILFEMIAGRALFPGGTPTEQLGLIFRTLGSPRPDRHPTICE 464
Query: 251 K-----RAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEHP 305
K A + + P+ + IP ++ +LL K L + R+SA EA++HP
Sbjct: 465 KPTFYPYANRHYNPDPLCRQIP-------RIDAHGFELLMKFLQYEGKDRVSAAEAVKHP 517
Query: 306 YLAT 309
+L T
Sbjct: 518 FLRT 521
>At1g18040 [DKL] KOG0659 Cdk activating kinase (CAK)/RNA polymerase II
transcription initiation/nucleotide excision repair
factor TFIIH/TFIIK kinase subunit CDK7
Length = 391
Score = 167 bits (422), Expect = 3e-41
Identities = 110/316 (34%), Positives = 164/316 (51%), Gaps = 20/316 (6%)
Query: 9 IPSHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRT-LRELKLLKFFH 67
+ Y +++G+G YG V A T VAIKKI+ + V T LRE+K+LK
Sbjct: 8 VADRYLKQEVLGQGTYGVVFKATDTKTEQTVAIKKIRLGKQREGVNITALREIKMLKEL- 66
Query: 68 SHENIISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQN--LSEDHIQYFVYQILRA 125
H +II ++D HK E ++LV E METDL+ +I N LS I+ ++ +
Sbjct: 67 KHPHIILLIDAFP----HK-ENLHLVFEFMETDLEAVIRDSNIFLSPADIKSYLLMTFKG 121
Query: 126 LKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRW 185
L H V+HRD+KP+NLL+ + LK+ DFGLAR S ++ T V RW
Sbjct: 122 LAYCHDKWVLHRDMKPNNLLIGVDGQLKLADFGLARIFGSPNRK-------FTHQVFARW 174
Query: 186 YRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDF 245
YRAPE++ ++Y A+D+W+ CI AE+++ +P G QL I G+P + +
Sbjct: 175 YRAPELLFGAKQYGAAVDVWAVACIFAELLLRRPFLQGNSDIDQLSKIFAAFGTPKADQW 234
Query: 246 EQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEHP 305
+ + +Y+ + P L V+ A+DLLSKM T++P RIS +ALEH
Sbjct: 235 PDL--TKLPDYVEYQFVP--APSLRSLFPAVSDDALDLLSKMFTYDPKARISIKQALEHR 290
Query: 306 YLATYHDPDDEPDYPQ 321
Y + P D P+
Sbjct: 291 YFTSAPAPTDPAKLPK 306
>At1g76540 [R] KOG0594 Protein kinase PCTAIRE and related kinases
Length = 313
Score = 166 bits (421), Expect = 4e-41
Identities = 107/320 (33%), Positives = 165/320 (51%), Gaps = 30/320 (9%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFV-TRTLRELKLLKFFHSHEN 71
++ ++ VGEG YG V A K T VA+KK + V + TLRE+ +L+ +
Sbjct: 14 FEKLEKVGEGTYGKVYRAREKATGKIVALKKTRLHEDEEGVPSTTLREISILRMLARDPH 73
Query: 72 IISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQ-----QNLSEDHIQYFVYQILRAL 126
++ ++D+ + S +YLV E M+TD++K I +N+ I+ +YQ+ + +
Sbjct: 74 VVRLMDVKQGLSKEGKTVLYLVFEYMDTDVKKFIRSFRSTGKNIPTQTIKSLMYQLCKGM 133
Query: 127 KSLHSAQVIHRDLKPSNLLLN-SNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRW 185
H ++HRDLKP NLL++ LK+ D GLAR + T + T W
Sbjct: 134 AFCHGHGILHRDLKPHNLLMDPKTMRLKIADLGLARAFTLPMKK-------YTHEILTLW 186
Query: 186 YRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDF 245
YRAPE++L Y+TA+D+WS GCI AE++ + +F G QL I ++ G+P E +
Sbjct: 187 YRAPEVLLGATHYSTAVDMWSVGCIFAELVTNQAIFQGDSELQQLLHIFKLFGTPNEEMW 246
Query: 246 EQIKS-KRAKEYISQLP--MKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEAL 302
+ + K EY P + +P ++ +DLLSKML + P KRISA A+
Sbjct: 247 PGVSTLKNWHEYPQWKPSTLSSAVP-------NLDEAGVDLLSKMLQYEPAKRISAKMAM 299
Query: 303 EHPYLATYHDPDDEPDYPQL 322
EHPY DD P+ L
Sbjct: 300 EHPYF------DDLPEKSSL 313
>YBR160w [R] KOG0594 Protein kinase PCTAIRE and related kinases
Length = 298
Score = 166 bits (419), Expect = 6e-41
Identities = 114/313 (36%), Positives = 173/313 (54%), Gaps = 41/313 (13%)
Query: 11 SHYQLVDLVGEGAYGTVCSAIH-KPTNTK--VAIKKIQPFSRSMFVTRT-LRELKLLKFF 66
++Y+ ++ VGEG YG V A+ +P + VA+KKI+ S V T +RE+ LLK
Sbjct: 6 ANYKRLEKVGEGTYGVVYKALDLRPGQGQRVVALKKIRLESEDEGVPSTAIREISLLKEL 65
Query: 67 HSHENIISVLDIVRPTSWHKFEAVYLVQELMETDLQK----IINQQNLSEDHIQYFVYQI 122
+NI+ + DIV + HK +YLV E ++ DL++ I Q L D ++ F+ Q+
Sbjct: 66 KD-DNIVRLYDIVHSDA-HK---LYLVFEFLDLDLKRYMEGIPKDQPLGADIVKKFMMQL 120
Query: 123 LRALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVA 182
+ + HS +++HRDLKP NLL+N + +LK+ DFGLAR ++ T +
Sbjct: 121 CKGIAYCHSHRILHRDLKPQNLLINKDGNLKLGDFGLARAFGVPLRA-------YTHEIV 173
Query: 183 TRWYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPT- 241
T WYRAPE++L ++Y+T +D WS GCI AEM KP+F G Q++ I VLG+P
Sbjct: 174 TLWYRAPEVLLGGKQYSTGVDTWSIGCIFAEMCNRKPIFSGDSEIDQIFKIFRVLGTPNE 233
Query: 242 --------LEDFEQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPD 293
L DF+ + ++ +SQ+ +P ++P IDLL K+L ++P
Sbjct: 234 AIWPDIVYLPDFKPSFPQWRRKDLSQV-----VP-------SLDPRGIDLLDKLLAYDPI 281
Query: 294 KRISAVEALEHPY 306
RISA A HPY
Sbjct: 282 NRISARRAAIHPY 294
>SPBC19F8.07 [DKL] KOG0659 Cdk activating kinase (CAK)/RNA polymerase II
transcription initiation/nucleotide excision repair
factor TFIIH/TFIIK kinase subunit CDK7
Length = 335
Score = 166 bits (419), Expect = 6e-41
Identities = 105/325 (32%), Positives = 170/325 (52%), Gaps = 21/325 (6%)
Query: 19 VGEGAYGTVCSAIHKPTNTKVAIKKIQ--PFSRSMFVTRTLRELKLLKFFHSHENIISVL 76
VGEG Y V K TN +VAIKKI+ F + ++ LRE+K L+ H+N+I ++
Sbjct: 17 VGEGTYAVVFLGRQKETNRRVAIKKIKVGQFKDGIDIS-ALREIKFLRESR-HDNVIELV 74
Query: 77 DIVRPTSWHKFEAVYLVQELMETDLQKIINQQNL--SEDHIQYFVYQILRALKSLHSAQV 134
D+ S + ++ E +++DL+ +I + + HI+ ++ +LR L +HS +
Sbjct: 75 DVFSTKS-----NLNIILEFLDSDLEMLIKDKFIVFQPAHIKSWMVMLLRGLHHIHSRFI 129
Query: 135 IHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRAPEIMLS 194
+HRDLKP+NLL++S+ LK+ DFGL+R + M+ V TRWYR PE+ +
Sbjct: 130 LHRDLKPNNLLISSDGVLKLADFGLSRDFGTPSH--------MSHQVITRWYRPPELFMG 181
Query: 195 FQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQIKSKRAK 254
+ Y T +D+WS GCI AE+++ P PG+ QL +I LG+P E + ++
Sbjct: 182 CRSYGTGVDMWSVGCIFAELMLRTPYLPGESDLDQLNVIFRALGTPEPEVIKSMQQLPNY 241
Query: 255 EYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEHPYLATYHDPD 314
+ +P G L IDLL ML +NP +R +A +ALEH Y + P
Sbjct: 242 VEMKHIPPPNG--GMEALFSAAGHEEIDLLKMMLDYNPYRRPTAQQALEHHYFSALPKPT 299
Query: 315 DEPDYPQLNLEDNFWKIDNEARDKN 339
P+ E+ + ++ + +N
Sbjct: 300 HPSLLPRKGGEEGIKHVSSDLQRQN 324
>Hs7657498 [T] KOG0661 MAPK related serine/threonine protein kinase
Length = 419
Score = 166 bits (419), Expect = 6e-41
Identities = 99/299 (33%), Positives = 166/299 (55%), Gaps = 21/299 (7%)
Query: 12 HYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTLRELKLLKFFHSHEN 71
+Y+ + +GEG + V A K+++ S+ LRE++ L+ + H N
Sbjct: 3 NYKAIGKIGEGTFSEVMKMQSLRDGNYYACKQMKQRFESIEQVNNLREIQALRRLNPHPN 62
Query: 72 IISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQN--LSEDHIQYFVYQILRALKSL 129
I+ + ++V K ++ L+ ELM+ ++ ++I + LSE I +++YQ+ ++L +
Sbjct: 63 ILMLHEVVFD---RKSGSLALICELMDMNIYELIRGRRYPLSEKKIMHYMYQLCKSLDHI 119
Query: 130 HSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRAP 189
H + HRD+KP N+L+ + LK+ DFG R + S TEY++TRWYRAP
Sbjct: 120 HRNGIFHRDVKPENILIKQDV-LKLGDFGSCRSVYSKQP--------YTEYISTRWYRAP 170
Query: 190 EIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQIK 249
E +L+ YT MD+WS GC+ E+ +PLFPG + Q+ I +V+G+P + + K
Sbjct: 171 ECLLTDGFYTYKMDLWSAGCVFYEIASLQPLFPGVNELDQISKIHDVIGTPAQKILTKFK 230
Query: 250 SKRAKEYISQLPMKK--GIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEHPY 306
RA + P KK GIP +L ++P + LL M+ ++PD+RI+A +AL+HPY
Sbjct: 231 QSRAMNF--DFPFKKGSGIP---LLTTNLSPQCLSLLHAMVAYDPDERIAAHQALQHPY 284
>Hs4502741 [R] KOG0594 Protein kinase PCTAIRE and related kinases
Length = 326
Score = 165 bits (417), Expect = 1e-40
Identities = 109/303 (35%), Positives = 164/303 (53%), Gaps = 25/303 (8%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTK-VAIKKIQ-PFSRSMFVTRTLRELKLLKFFHS-- 68
Y+ V +GEGAYG V A + VA+K+++ T+RE+ +L+ +
Sbjct: 13 YECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFE 72
Query: 69 HENIISVLDIVRPTSWHKFEAVYLVQELMETDLQKIIN---QQNLSEDHIQYFVYQILRA 125
H N++ + D+ + + + LV E ++ DL ++ + + + I+ ++Q+LR
Sbjct: 73 HPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRG 132
Query: 126 LKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRW 185
L LHS +V+HRDLKP N+L+ S+ +K+ DFGLAR + +T V T W
Sbjct: 133 LDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMA--------LTSVVVTLW 184
Query: 186 YRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDF 245
YRAPE++L Y T +D+WS GCI AEM KPLF G QL IL+V+G P ED+
Sbjct: 185 YRAPEVLLQ-SSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDW 243
Query: 246 --EQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALE 303
+ ++A S P++K + +++ L DLL K LTFNP KRISA AL
Sbjct: 244 PRDVALPRQAFHSKSAQPIEKFV-------TDIDELGKDLLLKCLTFNPAKRISAYSALS 296
Query: 304 HPY 306
HPY
Sbjct: 297 HPY 299
>Hs21040235 [R] KOG0594 Protein kinase PCTAIRE and related kinases
Length = 384
Score = 165 bits (417), Expect = 1e-40
Identities = 114/325 (35%), Positives = 168/325 (51%), Gaps = 27/325 (8%)
Query: 3 RTITYDIPSHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTLRELKL 62
+++ + S Y ++ +GEG+Y TV I + VA+K I + +RE L
Sbjct: 42 KSLPFGAASSYLNLEKLGEGSYATVYKGISRINGQLVALKVISMNAEEGVPFTAIREASL 101
Query: 63 LKFFHSHENIISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQ--NLSEDHIQYFVY 120
LK H NI+ + DI+ H E + V E M TDL + ++Q L +++ F++
Sbjct: 102 LKGL-KHANIVLLHDII-----HTKETLTFVFEYMHTDLAQYMSQHPGGLHPHNVRLFMF 155
Query: 121 QILRALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEY 180
Q+LR L +H V+HRDLKP NLL++ +LK+ DFGLAR + Q+ +
Sbjct: 156 QLLRGLAYIHHQHVLHRDLKPQNLLISHLGELKLADFGLARAKSIPSQT-------YSSE 208
Query: 181 VATRWYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPG-KDYHHQLWIILEVLGS 239
V T WYR P+ +L EY++ +DIW GCI EM G+PLFPG + QL I EVLG
Sbjct: 209 VVTLWYRPPDALLGATEYSSELDIWGAGCIFIEMFQGQPLFPGVSNILEQLEKIWEVLGV 268
Query: 240 PTLEDF---EQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRI 296
PT + + ++ + + + P + W N L + P A DL S+ML P R+
Sbjct: 269 PTEDTWPGVSKLPNYNPEWFPLPTPRSLHVVW-NRLGRV--PEAEDLASQMLKGFPRDRV 325
Query: 297 SAVEALEHPYLAT-----YHDPDDE 316
SA EAL H Y + Y PD+E
Sbjct: 326 SAQEALVHDYFSALPSQLYQLPDEE 350
>CE18009 [R] KOG0594 Protein kinase PCTAIRE and related kinases
Length = 384
Score = 164 bits (416), Expect = 1e-40
Identities = 102/318 (32%), Positives = 173/318 (54%), Gaps = 31/318 (9%)
Query: 8 DIPSHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRT-LRELKLLKFF 66
D+ + + +GEG YG V AIH N K A+K I+ + T LRE+ +K
Sbjct: 40 DLQGRFCSLRRIGEGTYGVVFKAIHVRDNVKCALKMIRTDRDEEGIPSTCLREISCIKDL 99
Query: 67 HSHENIISVLDIVRPTSW--------HKFEA---VYLVQELMETDLQKIINQQN-----L 110
H+NI+++ DI+ + + KF + +Y+V E ++ DL+ ++ L
Sbjct: 100 Q-HDNIVTLFDIIYASHFLNYNNIFFEKFSSNSKLYMVFEFIDRDLKNLLEMLEPTNSVL 158
Query: 111 SEDHIQYFVYQILRALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSR 170
++++ F++Q+L AL H +++HRDLKP N+L++ + +K+ DFGLAR + ++
Sbjct: 159 PPNYVKSFMWQLLSALSYCHLRRIVHRDLKPQNILVSDSGVIKIADFGLARNFSFPSRN- 217
Query: 171 ENMVGFMTEYVATRWYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQL 230
T V T WYR PEI+L Q Y+T++D+WS GCI +E+ KPLFPG+ QL
Sbjct: 218 ------YTHEVVTLWYRPPEILLGSQRYSTSLDMWSLGCIFSEIASNKPLFPGECEISQL 271
Query: 231 WIILEVLGSPTLEDFEQIKS-KRAKEYISQLPMK-KGIPWANVLNKEVNPLAIDLLSKML 288
+ I E++G+P ++ + + S K Q P+ K + + L +D+L ++L
Sbjct: 272 FKIFEIVGTPNIKSWPGVDSFPHYKAVFPQWPVNLKKLEETSCLTGN----GLDVLREIL 327
Query: 289 TFNPDKRISAVEALEHPY 306
+ P++R++A AL H Y
Sbjct: 328 RYPPERRLTAKGALSHRY 345
>Hs16357498 [R] KOG0663 Protein kinase PITSLRE and related kinases
Length = 777
Score = 164 bits (415), Expect = 2e-40
Identities = 111/319 (34%), Positives = 173/319 (53%), Gaps = 31/319 (9%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQ-PFSRSMFVTRTLRELKLLKFFHSHEN 71
+Q ++ + EG YG V A K T+ VA+K+++ + F +LRE+ + H N
Sbjct: 420 FQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTI-LKAQHPN 478
Query: 72 IISVLDIVRPTSWHKFEAVYLVQELMETDLQKIIN--QQNLSEDHIQYFVYQILRALKSL 129
I++V +IV ++ K +Y+V +E DL+ ++ +Q ++ + Q+LR +K L
Sbjct: 479 IVTVREIVVGSNMDK---IYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHL 535
Query: 130 HSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRAP 189
H ++HRDLK SNLLL+ LKV DFGLAR S ++ T V T+WYRAP
Sbjct: 536 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKA-------YTPVVVTQWYRAP 588
Query: 190 EIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQIK 249
E++L +EY+TA+D+WS GCI E++ KPLFPG Q+ + + LG+P
Sbjct: 589 ELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTP--------- 639
Query: 250 SKRAKEYISQLPMKKGIPWA----NVLNKEVNPL----AIDLLSKMLTFNPDKRISAVEA 301
S++ S+LP+ K + ++ N L K L DL++K LT+ P +RISA +
Sbjct: 640 SEKIWPGYSELPVVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDG 699
Query: 302 LEHPYLATYHDPDDEPDYP 320
L+H Y P D +P
Sbjct: 700 LKHEYFRETPLPIDPSMFP 718
>Hs16357486 [R] KOG0663 Protein kinase PITSLRE and related kinases
Length = 780
Score = 164 bits (415), Expect = 2e-40
Identities = 111/319 (34%), Positives = 173/319 (53%), Gaps = 31/319 (9%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQ-PFSRSMFVTRTLRELKLLKFFHSHEN 71
+Q ++ + EG YG V A K T+ VA+K+++ + F +LRE+ + H N
Sbjct: 423 FQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTI-LKAQHPN 481
Query: 72 IISVLDIVRPTSWHKFEAVYLVQELMETDLQKIIN--QQNLSEDHIQYFVYQILRALKSL 129
I++V +IV ++ K +Y+V +E DL+ ++ +Q ++ + Q+LR +K L
Sbjct: 482 IVTVREIVVGSNMDK---IYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHL 538
Query: 130 HSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRAP 189
H ++HRDLK SNLLL+ LKV DFGLAR S ++ T V T+WYRAP
Sbjct: 539 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKA-------YTPVVVTQWYRAP 591
Query: 190 EIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQIK 249
E++L +EY+TA+D+WS GCI E++ KPLFPG Q+ + + LG+P
Sbjct: 592 ELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTP--------- 642
Query: 250 SKRAKEYISQLPMKKGIPWA----NVLNKEVNPL----AIDLLSKMLTFNPDKRISAVEA 301
S++ S+LP+ K + ++ N L K L DL++K LT+ P +RISA +
Sbjct: 643 SEKIWPGYSELPVVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDG 702
Query: 302 LEHPYLATYHDPDDEPDYP 320
L+H Y P D +P
Sbjct: 703 LKHEYFRETPLPIDPSMFP 721
>Hs16357484 [R] KOG0663 Protein kinase PITSLRE and related kinases
Length = 767
Score = 164 bits (415), Expect = 2e-40
Identities = 111/319 (34%), Positives = 173/319 (53%), Gaps = 31/319 (9%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQ-PFSRSMFVTRTLRELKLLKFFHSHEN 71
+Q ++ + EG YG V A K T+ VA+K+++ + F +LRE+ + H N
Sbjct: 410 FQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTI-LKAQHPN 468
Query: 72 IISVLDIVRPTSWHKFEAVYLVQELMETDLQKIIN--QQNLSEDHIQYFVYQILRALKSL 129
I++V +IV ++ K +Y+V +E DL+ ++ +Q ++ + Q+LR +K L
Sbjct: 469 IVTVREIVVGSNMDK---IYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHL 525
Query: 130 HSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRAP 189
H ++HRDLK SNLLL+ LKV DFGLAR S ++ T V T+WYRAP
Sbjct: 526 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKA-------YTPVVVTQWYRAP 578
Query: 190 EIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQIK 249
E++L +EY+TA+D+WS GCI E++ KPLFPG Q+ + + LG+P
Sbjct: 579 ELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTP--------- 629
Query: 250 SKRAKEYISQLPMKKGIPWA----NVLNKEVNPL----AIDLLSKMLTFNPDKRISAVEA 301
S++ S+LP+ K + ++ N L K L DL++K LT+ P +RISA +
Sbjct: 630 SEKIWPGYSELPVVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDG 689
Query: 302 LEHPYLATYHDPDDEPDYP 320
L+H Y P D +P
Sbjct: 690 LKHEYFRETPLPIDPSMFP 708
>Hs16357482 [R] KOG0663 Protein kinase PITSLRE and related kinases
Length = 776
Score = 164 bits (415), Expect = 2e-40
Identities = 111/319 (34%), Positives = 173/319 (53%), Gaps = 31/319 (9%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQ-PFSRSMFVTRTLRELKLLKFFHSHEN 71
+Q ++ + EG YG V A K T+ VA+K+++ + F +LRE+ + H N
Sbjct: 419 FQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTI-LKAQHPN 477
Query: 72 IISVLDIVRPTSWHKFEAVYLVQELMETDLQKIIN--QQNLSEDHIQYFVYQILRALKSL 129
I++V +IV ++ K +Y+V +E DL+ ++ +Q ++ + Q+LR +K L
Sbjct: 478 IVTVREIVVGSNMDK---IYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHL 534
Query: 130 HSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRAP 189
H ++HRDLK SNLLL+ LKV DFGLAR S ++ T V T+WYRAP
Sbjct: 535 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKA-------YTPVVVTQWYRAP 587
Query: 190 EIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQIK 249
E++L +EY+TA+D+WS GCI E++ KPLFPG Q+ + + LG+P
Sbjct: 588 ELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTP--------- 638
Query: 250 SKRAKEYISQLPMKKGIPWA----NVLNKEVNPL----AIDLLSKMLTFNPDKRISAVEA 301
S++ S+LP+ K + ++ N L K L DL++K LT+ P +RISA +
Sbjct: 639 SEKIWPGYSELPVVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDG 698
Query: 302 LEHPYLATYHDPDDEPDYP 320
L+H Y P D +P
Sbjct: 699 LKHEYFRETPLPIDPSMFP 717
>Hs16357480 [R] KOG0663 Protein kinase PITSLRE and related kinases
Length = 397
Score = 164 bits (415), Expect = 2e-40
Identities = 111/319 (34%), Positives = 173/319 (53%), Gaps = 31/319 (9%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQ-PFSRSMFVTRTLRELKLLKFFHSHEN 71
+Q ++ + EG YG V A K T+ VA+K+++ + F +LRE+ + H N
Sbjct: 40 FQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTI-LKAQHPN 98
Query: 72 IISVLDIVRPTSWHKFEAVYLVQELMETDLQKIIN--QQNLSEDHIQYFVYQILRALKSL 129
I++V +IV ++ K +Y+V +E DL+ ++ +Q ++ + Q+LR +K L
Sbjct: 99 IVTVREIVVGSNMDK---IYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHL 155
Query: 130 HSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRAP 189
H ++HRDLK SNLLL+ LKV DFGLAR S ++ T V T+WYRAP
Sbjct: 156 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKA-------YTPVVVTQWYRAP 208
Query: 190 EIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQIK 249
E++L +EY+TA+D+WS GCI E++ KPLFPG Q+ + + LG+P
Sbjct: 209 ELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTP--------- 259
Query: 250 SKRAKEYISQLPMKKGIPWA----NVLNKEVNPL----AIDLLSKMLTFNPDKRISAVEA 301
S++ S+LP+ K + ++ N L K L DL++K LT+ P +RISA +
Sbjct: 260 SEKIWPGYSELPVVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDG 319
Query: 302 LEHPYLATYHDPDDEPDYP 320
L+H Y P D +P
Sbjct: 320 LKHEYFRETPLPIDPSMFP 338
>Hs16357496 [R] KOG0663 Protein kinase PITSLRE and related kinases
Length = 439
Score = 164 bits (414), Expect = 2e-40
Identities = 112/319 (35%), Positives = 172/319 (53%), Gaps = 31/319 (9%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQ-PFSRSMFVTRTLRELKLLKFFHSHEN 71
+Q ++ + EG YG V A K T+ VA+K+++ + F +LRE+ + H N
Sbjct: 82 FQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTI-LKAQHPN 140
Query: 72 IISVLDIVRPTSWHKFEAVYLVQELMETDLQKIIN--QQNLSEDHIQYFVYQILRALKSL 129
I++V +IV ++ K +Y+V +E DL+ ++ +Q ++ + Q+LR +K L
Sbjct: 141 IVTVREIVVGSNMDK---IYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHL 197
Query: 130 HSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRAP 189
H ++HRDLK SNLLL+ LKV DFGLAR S ++ T V T WYRAP
Sbjct: 198 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKA-------YTPVVVTLWYRAP 250
Query: 190 EIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQIK 249
E++L +EY+TA+D+WS GCI E++ KPLFPGK Q+ + + LG+P
Sbjct: 251 ELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTP--------- 301
Query: 250 SKRAKEYISQLPMKKGIPWA----NVLNKEVNPL----AIDLLSKMLTFNPDKRISAVEA 301
S++ S+LP K + ++ N L K L DL++K LT+ P +RISA +
Sbjct: 302 SEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDG 361
Query: 302 LEHPYLATYHDPDDEPDYP 320
L+H Y P D +P
Sbjct: 362 LKHEYFRETPLPIDPSMFP 380
>Hs16357494 [R] KOG0663 Protein kinase PITSLRE and related kinases
Length = 775
Score = 164 bits (414), Expect = 2e-40
Identities = 111/319 (34%), Positives = 173/319 (53%), Gaps = 31/319 (9%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSM-FVTRTLRELKLLKFFHSHEN 71
+Q ++ + EG YG V A K T+ VA+K+++ + F +LRE+ + H N
Sbjct: 418 FQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKENEGFPITSLREINTI-LKAQHPN 476
Query: 72 IISVLDIVRPTSWHKFEAVYLVQELMETDLQKIIN--QQNLSEDHIQYFVYQILRALKSL 129
I++V +IV ++ K +Y+V +E DL+ ++ +Q ++ + Q+LR +K L
Sbjct: 477 IVTVREIVVGSNMDK---IYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHL 533
Query: 130 HSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRAP 189
H ++HRDLK SNLLL+ LKV DFGLAR S ++ T V T+WYRAP
Sbjct: 534 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKA-------YTPVVVTQWYRAP 586
Query: 190 EIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQIK 249
E++L +EY+TA+D+WS GCI E++ KPLFPG Q+ + + LG+P
Sbjct: 587 ELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTP--------- 637
Query: 250 SKRAKEYISQLPMKKGIPWA----NVLNKEVNPL----AIDLLSKMLTFNPDKRISAVEA 301
S++ S+LP+ K + ++ N L K L DL++K LT+ P +RISA +
Sbjct: 638 SEKIWPGYSELPVVKKMTFSEHPYNNLRKRFGALLSEQGFDLMNKFLTYFPGRRISAEDG 697
Query: 302 LEHPYLATYHDPDDEPDYP 320
L+H Y P D +P
Sbjct: 698 LKHEYFRETPLPIDPSMFP 716
>Hs16357492 [R] KOG0663 Protein kinase PITSLRE and related kinases
Length = 777
Score = 164 bits (414), Expect = 2e-40
Identities = 111/319 (34%), Positives = 173/319 (53%), Gaps = 31/319 (9%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSM-FVTRTLRELKLLKFFHSHEN 71
+Q ++ + EG YG V A K T+ VA+K+++ + F +LRE+ + H N
Sbjct: 420 FQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKENEGFPITSLREINTI-LKAQHPN 478
Query: 72 IISVLDIVRPTSWHKFEAVYLVQELMETDLQKIIN--QQNLSEDHIQYFVYQILRALKSL 129
I++V +IV ++ K +Y+V +E DL+ ++ +Q ++ + Q+LR +K L
Sbjct: 479 IVTVREIVVGSNMDK---IYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHL 535
Query: 130 HSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRAP 189
H ++HRDLK SNLLL+ LKV DFGLAR S ++ T V T+WYRAP
Sbjct: 536 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKA-------YTPVVVTQWYRAP 588
Query: 190 EIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQIK 249
E++L +EY+TA+D+WS GCI E++ KPLFPG Q+ + + LG+P
Sbjct: 589 ELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTP--------- 639
Query: 250 SKRAKEYISQLPMKKGIPWA----NVLNKEVNPL----AIDLLSKMLTFNPDKRISAVEA 301
S++ S+LP+ K + ++ N L K L DL++K LT+ P +RISA +
Sbjct: 640 SEKIWPGYSELPVVKKMTFSEHPYNNLRKRFGALLSEQGFDLMNKFLTYFPGRRISAEDG 699
Query: 302 LEHPYLATYHDPDDEPDYP 320
L+H Y P D +P
Sbjct: 700 LKHEYFRETPLPIDPSMFP 718
>Hs16332372 [R] KOG0663 Protein kinase PITSLRE and related kinases
Length = 771
Score = 164 bits (414), Expect = 2e-40
Identities = 112/319 (35%), Positives = 172/319 (53%), Gaps = 31/319 (9%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQ-PFSRSMFVTRTLRELKLLKFFHSHEN 71
+Q ++ + EG YG V A K T+ VA+K+++ + F +LRE+ + H N
Sbjct: 414 FQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTI-LKAQHPN 472
Query: 72 IISVLDIVRPTSWHKFEAVYLVQELMETDLQKIIN--QQNLSEDHIQYFVYQILRALKSL 129
I++V +IV ++ K +Y+V +E DL+ ++ +Q ++ + Q+LR +K L
Sbjct: 473 IVTVREIVVGSNMDK---IYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHL 529
Query: 130 HSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRAP 189
H ++HRDLK SNLLL+ LKV DFGLAR S ++ T V T WYRAP
Sbjct: 530 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKA-------YTPVVVTLWYRAP 582
Query: 190 EIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQIK 249
E++L +EY+TA+D+WS GCI E++ KPLFPGK Q+ + + LG+P
Sbjct: 583 ELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTP--------- 633
Query: 250 SKRAKEYISQLPMKKGIPWA----NVLNKEVNPL----AIDLLSKMLTFNPDKRISAVEA 301
S++ S+LP K + ++ N L K L DL++K LT+ P +RISA +
Sbjct: 634 SEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDG 693
Query: 302 LEHPYLATYHDPDDEPDYP 320
L+H Y P D +P
Sbjct: 694 LKHEYFRETPLPIDPSMFP 712
>Hs16332370 [R] KOG0663 Protein kinase PITSLRE and related kinases
Length = 780
Score = 164 bits (414), Expect = 2e-40
Identities = 112/319 (35%), Positives = 172/319 (53%), Gaps = 31/319 (9%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQ-PFSRSMFVTRTLRELKLLKFFHSHEN 71
+Q ++ + EG YG V A K T+ VA+K+++ + F +LRE+ + H N
Sbjct: 423 FQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTI-LKAQHPN 481
Query: 72 IISVLDIVRPTSWHKFEAVYLVQELMETDLQKIIN--QQNLSEDHIQYFVYQILRALKSL 129
I++V +IV ++ K +Y+V +E DL+ ++ +Q ++ + Q+LR +K L
Sbjct: 482 IVTVREIVVGSNMDK---IYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHL 538
Query: 130 HSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRAP 189
H ++HRDLK SNLLL+ LKV DFGLAR S ++ T V T WYRAP
Sbjct: 539 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKA-------YTPVVVTLWYRAP 591
Query: 190 EIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQIK 249
E++L +EY+TA+D+WS GCI E++ KPLFPGK Q+ + + LG+P
Sbjct: 592 ELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTP--------- 642
Query: 250 SKRAKEYISQLPMKKGIPWA----NVLNKEVNPL----AIDLLSKMLTFNPDKRISAVEA 301
S++ S+LP K + ++ N L K L DL++K LT+ P +RISA +
Sbjct: 643 SEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDG 702
Query: 302 LEHPYLATYHDPDDEPDYP 320
L+H Y P D +P
Sbjct: 703 LKHEYFRETPLPIDPSMFP 721
>Hs16332368 [R] KOG0663 Protein kinase PITSLRE and related kinases
Length = 461
Score = 164 bits (414), Expect = 2e-40
Identities = 112/319 (35%), Positives = 172/319 (53%), Gaps = 31/319 (9%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQ-PFSRSMFVTRTLRELKLLKFFHSHEN 71
+Q ++ + EG YG V A K T+ VA+K+++ + F +LRE+ + H N
Sbjct: 104 FQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTI-LKAQHPN 162
Query: 72 IISVLDIVRPTSWHKFEAVYLVQELMETDLQKIIN--QQNLSEDHIQYFVYQILRALKSL 129
I++V +IV ++ K +Y+V +E DL+ ++ +Q ++ + Q+LR +K L
Sbjct: 163 IVTVREIVVGSNMDK---IYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHL 219
Query: 130 HSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRAP 189
H ++HRDLK SNLLL+ LKV DFGLAR S ++ T V T WYRAP
Sbjct: 220 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKA-------YTPVVVTLWYRAP 272
Query: 190 EIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQIK 249
E++L +EY+TA+D+WS GCI E++ KPLFPGK Q+ + + LG+P
Sbjct: 273 ELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTP--------- 323
Query: 250 SKRAKEYISQLPMKKGIPWA----NVLNKEVNPL----AIDLLSKMLTFNPDKRISAVEA 301
S++ S+LP K + ++ N L K L DL++K LT+ P +RISA +
Sbjct: 324 SEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDG 383
Query: 302 LEHPYLATYHDPDDEPDYP 320
L+H Y P D +P
Sbjct: 384 LKHEYFRETPLPIDPSMFP 402
>Hs16332366 [R] KOG0663 Protein kinase PITSLRE and related kinases
Length = 565
Score = 164 bits (414), Expect = 2e-40
Identities = 112/319 (35%), Positives = 172/319 (53%), Gaps = 31/319 (9%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQ-PFSRSMFVTRTLRELKLLKFFHSHEN 71
+Q ++ + EG YG V A K T+ VA+K+++ + F +LRE+ + H N
Sbjct: 208 FQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTI-LKAQHPN 266
Query: 72 IISVLDIVRPTSWHKFEAVYLVQELMETDLQKIIN--QQNLSEDHIQYFVYQILRALKSL 129
I++V +IV ++ K +Y+V +E DL+ ++ +Q ++ + Q+LR +K L
Sbjct: 267 IVTVREIVVGSNMDK---IYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHL 323
Query: 130 HSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRAP 189
H ++HRDLK SNLLL+ LKV DFGLAR S ++ T V T WYRAP
Sbjct: 324 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKA-------YTPVVVTLWYRAP 376
Query: 190 EIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQIK 249
E++L +EY+TA+D+WS GCI E++ KPLFPGK Q+ + + LG+P
Sbjct: 377 ELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTP--------- 427
Query: 250 SKRAKEYISQLPMKKGIPWA----NVLNKEVNPL----AIDLLSKMLTFNPDKRISAVEA 301
S++ S+LP K + ++ N L K L DL++K LT+ P +RISA +
Sbjct: 428 SEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDG 487
Query: 302 LEHPYLATYHDPDDEPDYP 320
L+H Y P D +P
Sbjct: 488 LKHEYFRETPLPIDPSMFP 506
>Hs16332364 [R] KOG0663 Protein kinase PITSLRE and related kinases
Length = 748
Score = 164 bits (414), Expect = 2e-40
Identities = 112/319 (35%), Positives = 172/319 (53%), Gaps = 31/319 (9%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQ-PFSRSMFVTRTLRELKLLKFFHSHEN 71
+Q ++ + EG YG V A K T+ VA+K+++ + F +LRE+ + H N
Sbjct: 391 FQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTI-LKAQHPN 449
Query: 72 IISVLDIVRPTSWHKFEAVYLVQELMETDLQKIIN--QQNLSEDHIQYFVYQILRALKSL 129
I++V +IV ++ K +Y+V +E DL+ ++ +Q ++ + Q+LR +K L
Sbjct: 450 IVTVREIVVGSNMDK---IYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHL 506
Query: 130 HSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRAP 189
H ++HRDLK SNLLL+ LKV DFGLAR S ++ T V T WYRAP
Sbjct: 507 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKA-------YTPVVVTLWYRAP 559
Query: 190 EIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQIK 249
E++L +EY+TA+D+WS GCI E++ KPLFPGK Q+ + + LG+P
Sbjct: 560 ELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTP--------- 610
Query: 250 SKRAKEYISQLPMKKGIPWA----NVLNKEVNPL----AIDLLSKMLTFNPDKRISAVEA 301
S++ S+LP K + ++ N L K L DL++K LT+ P +RISA +
Sbjct: 611 SEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDG 670
Query: 302 LEHPYLATYHDPDDEPDYP 320
L+H Y P D +P
Sbjct: 671 LKHEYFRETPLPIDPSMFP 689
>Hs16332362 [R] KOG0663 Protein kinase PITSLRE and related kinases
Length = 737
Score = 164 bits (414), Expect = 2e-40
Identities = 112/319 (35%), Positives = 172/319 (53%), Gaps = 31/319 (9%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQ-PFSRSMFVTRTLRELKLLKFFHSHEN 71
+Q ++ + EG YG V A K T+ VA+K+++ + F +LRE+ + H N
Sbjct: 380 FQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTI-LKAQHPN 438
Query: 72 IISVLDIVRPTSWHKFEAVYLVQELMETDLQKIIN--QQNLSEDHIQYFVYQILRALKSL 129
I++V +IV ++ K +Y+V +E DL+ ++ +Q ++ + Q+LR +K L
Sbjct: 439 IVTVREIVVGSNMDK---IYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHL 495
Query: 130 HSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRAP 189
H ++HRDLK SNLLL+ LKV DFGLAR S ++ T V T WYRAP
Sbjct: 496 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKA-------YTPVVVTLWYRAP 548
Query: 190 EIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQIK 249
E++L +EY+TA+D+WS GCI E++ KPLFPGK Q+ + + LG+P
Sbjct: 549 ELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTP--------- 599
Query: 250 SKRAKEYISQLPMKKGIPWA----NVLNKEVNPL----AIDLLSKMLTFNPDKRISAVEA 301
S++ S+LP K + ++ N L K L DL++K LT+ P +RISA +
Sbjct: 600 SEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDG 659
Query: 302 LEHPYLATYHDPDDEPDYP 320
L+H Y P D +P
Sbjct: 660 LKHEYFRETPLPIDPSMFP 678
>Hs16332360 [R] KOG0663 Protein kinase PITSLRE and related kinases
Length = 526
Score = 164 bits (414), Expect = 2e-40
Identities = 112/319 (35%), Positives = 172/319 (53%), Gaps = 31/319 (9%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQ-PFSRSMFVTRTLRELKLLKFFHSHEN 71
+Q ++ + EG YG V A K T+ VA+K+++ + F +LRE+ + H N
Sbjct: 169 FQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTI-LKAQHPN 227
Query: 72 IISVLDIVRPTSWHKFEAVYLVQELMETDLQKIIN--QQNLSEDHIQYFVYQILRALKSL 129
I++V +IV ++ K +Y+V +E DL+ ++ +Q ++ + Q+LR +K L
Sbjct: 228 IVTVREIVVGSNMDK---IYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHL 284
Query: 130 HSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRAP 189
H ++HRDLK SNLLL+ LKV DFGLAR S ++ T V T WYRAP
Sbjct: 285 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKA-------YTPVVVTLWYRAP 337
Query: 190 EIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQIK 249
E++L +EY+TA+D+WS GCI E++ KPLFPGK Q+ + + LG+P
Sbjct: 338 ELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTP--------- 388
Query: 250 SKRAKEYISQLPMKKGIPWA----NVLNKEVNPL----AIDLLSKMLTFNPDKRISAVEA 301
S++ S+LP K + ++ N L K L DL++K LT+ P +RISA +
Sbjct: 389 SEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDG 448
Query: 302 LEHPYLATYHDPDDEPDYP 320
L+H Y P D +P
Sbjct: 449 LKHEYFRETPLPIDPSMFP 467
>Hs16332358 [R] KOG0663 Protein kinase PITSLRE and related kinases
Length = 782
Score = 164 bits (414), Expect = 2e-40
Identities = 112/319 (35%), Positives = 172/319 (53%), Gaps = 31/319 (9%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQ-PFSRSMFVTRTLRELKLLKFFHSHEN 71
+Q ++ + EG YG V A K T+ VA+K+++ + F +LRE+ + H N
Sbjct: 425 FQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTI-LKAQHPN 483
Query: 72 IISVLDIVRPTSWHKFEAVYLVQELMETDLQKIIN--QQNLSEDHIQYFVYQILRALKSL 129
I++V +IV ++ K +Y+V +E DL+ ++ +Q ++ + Q+LR +K L
Sbjct: 484 IVTVREIVVGSNMDK---IYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHL 540
Query: 130 HSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRAP 189
H ++HRDLK SNLLL+ LKV DFGLAR S ++ T V T WYRAP
Sbjct: 541 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKA-------YTPVVVTLWYRAP 593
Query: 190 EIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQIK 249
E++L +EY+TA+D+WS GCI E++ KPLFPGK Q+ + + LG+P
Sbjct: 594 ELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTP--------- 644
Query: 250 SKRAKEYISQLPMKKGIPWA----NVLNKEVNPL----AIDLLSKMLTFNPDKRISAVEA 301
S++ S+LP K + ++ N L K L DL++K LT+ P +RISA +
Sbjct: 645 SEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDG 704
Query: 302 LEHPYLATYHDPDDEPDYP 320
L+H Y P D +P
Sbjct: 705 LKHEYFRETPLPIDPSMFP 723
>Hs10835055 [R] KOG0663 Protein kinase PITSLRE and related kinases
Length = 795
Score = 164 bits (414), Expect = 2e-40
Identities = 112/319 (35%), Positives = 172/319 (53%), Gaps = 31/319 (9%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQ-PFSRSMFVTRTLRELKLLKFFHSHEN 71
+Q ++ + EG YG V A K T+ VA+K+++ + F +LRE+ + H N
Sbjct: 438 FQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTI-LKAQHPN 496
Query: 72 IISVLDIVRPTSWHKFEAVYLVQELMETDLQKIIN--QQNLSEDHIQYFVYQILRALKSL 129
I++V +IV ++ K +Y+V +E DL+ ++ +Q ++ + Q+LR +K L
Sbjct: 497 IVTVREIVVGSNMDK---IYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHL 553
Query: 130 HSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRAP 189
H ++HRDLK SNLLL+ LKV DFGLAR S ++ T V T WYRAP
Sbjct: 554 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKA-------YTPVVVTLWYRAP 606
Query: 190 EIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQIK 249
E++L +EY+TA+D+WS GCI E++ KPLFPGK Q+ + + LG+P
Sbjct: 607 ELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTP--------- 657
Query: 250 SKRAKEYISQLPMKKGIPWA----NVLNKEVNPL----AIDLLSKMLTFNPDKRISAVEA 301
S++ S+LP K + ++ N L K L DL++K LT+ P +RISA +
Sbjct: 658 SEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDG 717
Query: 302 LEHPYLATYHDPDDEPDYP 320
L+H Y P D +P
Sbjct: 718 LKHEYFRETPLPIDPSMFP 736
>At1g66750 [DKL] KOG0659 Cdk activating kinase (CAK)/RNA polymerase II
transcription initiation/nucleotide excision repair
factor TFIIH/TFIIK kinase subunit CDK7
Length = 348
Score = 164 bits (414), Expect = 2e-40
Identities = 112/349 (32%), Positives = 179/349 (51%), Gaps = 28/349 (8%)
Query: 18 LVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRT-LRELKLLKFFHSHENIISVL 76
++GEG YG V A T VA+KKI+ ++ V T LRE+KLLK + H +I+ ++
Sbjct: 18 ILGEGTYGVVYKATDTKTGKTVAVKKIRLGNQKEGVNFTALREIKLLKELN-HPHIVELI 76
Query: 77 DIVRPTSWHKFEAVYLVQELMETDLQKIINQQN--LSEDHIQYFVYQILRALKSLHSAQV 134
D ++ +++LV E M+TDL+ +I +N LS I+ ++ L+ L H V
Sbjct: 77 D-----AFPHDGSLHLVFEYMQTDLEAVIRDRNIFLSPGDIKSYMLMTLKGLAYCHKKWV 131
Query: 135 IHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRAPEIMLS 194
+HRD+KP+NLL+ N LK+ DFGLAR S ++ T V WYRAPE++
Sbjct: 132 LHRDMKPNNLLIGENGLLKLADFGLARLFGSPNRR-------FTHQVFATWYRAPELLFG 184
Query: 195 FQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPT---LEDFEQIKSK 251
++Y +D+W+ GCI AE+++ +P PG QL I + G+P D +
Sbjct: 185 SRQYGAGVDVWAAGCIFAELLLRRPFLPGSTEIDQLGKIFQAFGTPVPSQWSDMIYLPDY 244
Query: 252 RAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEHPYLATYH 311
Y P++ P A + A+DLL+KM ++P +RI+ +AL+H Y ++
Sbjct: 245 MEFSYTPAPPLRTIFPMA-------SDDALDLLAKMFIYDPRQRITIQQALDHRYFSSSP 297
Query: 312 DPDDEPDYPQLNLEDNFWKIDNEARDKNEEDDIPLELLKKMLYGEVMKP 360
P EP Q+ ++ +A ++N+ + P L VM P
Sbjct: 298 SP-TEPGKLQIPASKGD-ALEPKASEQNQHGNSPAVLSPPGKMRRVMGP 344
>7302908 [R] KOG0594 Protein kinase PCTAIRE and related kinases
Length = 317
Score = 164 bits (414), Expect = 2e-40
Identities = 113/303 (37%), Positives = 167/303 (54%), Gaps = 20/303 (6%)
Query: 10 PSHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQ-PFSRSMFVTRTLRELKLLKFFHS 68
P +YQ ++++GEGAYGTV A T VA+KK++ + + TLRE+ LLK ++
Sbjct: 23 PFNYQELNIIGEGAYGTVYRARDVITGNIVALKKVRISLNENGVPMSTLREISLLKQLNA 82
Query: 69 --HENIISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQ---QNLSEDHIQYFVYQIL 123
H NI+ + ++ + + LV E +E DL +I++ +S IQ ++L
Sbjct: 83 SNHANIVKLYEVCQFLERDGQLLILLVFEHVEQDLSDLIDRLPKSGMSPPTIQRLSRELL 142
Query: 124 RALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVAT 183
+ LHS ++IHRDLKP NLL++S LK+ DFGLA+ S + +T V T
Sbjct: 143 TGVDFLHSHRIIHRDLKPQNLLVSSQGHLKIADFGLAKTYGSEMK--------LTSVVVT 194
Query: 184 RWYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLE 243
WYRAPE++L+ Q Y + +DIWS CI+ EM + LFPG +QL I E+ G PT +
Sbjct: 195 LWYRAPEVLLA-QPYNSTVDIWSAACIIFEMFNRRALFPGTSEKNQLDRIFELTGRPTEQ 253
Query: 244 DFEQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALE 303
+ Q S A E+ Q K+ + L K A DLL+KML+++ R SA+ LE
Sbjct: 254 QWPQTISV-ALEHFPQRHPKRPKDFCPHLCK----YADDLLNKMLSYDLHLRPSALACLE 308
Query: 304 HPY 306
H Y
Sbjct: 309 HDY 311
>CE21213 [UT] KOG0662 Cyclin-dependent kinase CDK5
Length = 292
Score = 163 bits (413), Expect = 3e-40
Identities = 110/312 (35%), Positives = 162/312 (51%), Gaps = 34/312 (10%)
Query: 12 HYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFV-TRTLRELKLLKFFHSHE 70
+Y ++ +GEG YGTV A +K + VA+K+++ V + LRE+ +L+ H
Sbjct: 3 NYDKMEKIGEGTYGTVFKARNKNSGEIVALKRVRLDDDDEGVPSSALREICILREL-KHR 61
Query: 71 NIISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQN--LSEDHIQYFVYQILRALKS 128
N++ + D+V H + LV E + DL+K + N + + + Q+LR L
Sbjct: 62 NVVRLYDVV-----HSENKLTLVFEYCDQDLKKFFDSLNGYMDAQTARSLMLQLLRGLSF 116
Query: 129 LHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRA 188
H+ V+HRDLKP NLL+N+N LK+ DFGLAR V + V T WYR
Sbjct: 117 CHAHHVLHRDLKPQNLLINTNGTLKLADFGLARAFGVP-------VRCFSAEVVTLWYRP 169
Query: 189 PEIMLSFQEYTTAMDIWSCGCILAEMI-MGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQ 247
P+++ + Y T++D+WS GCI AE+ G+PLFPG D QL I + LGSP+ +++
Sbjct: 170 PDVLFGAKLYNTSIDMWSAGCIFAEISNAGRPLFPGADVDDQLKRIFKQLGSPSEDNWPS 229
Query: 248 IKSKRAKEYISQLPMKKGIP-------WANVLNKEVNPLAIDLLSKMLTFNPDKRISAVE 300
I+QLP K P W+ ++ +N DLL K+L NP RI A
Sbjct: 230 ---------ITQLPDYKPYPIYHPTLTWSQIV-PNLNSRGRDLLQKLLVCNPAGRIDADA 279
Query: 301 ALEHPYLATYHD 312
AL H Y A D
Sbjct: 280 ALRHAYFADTSD 291
>Hs7706549 [D] KOG0600 Cdc2-related protein kinase
Length = 1490
Score = 163 bits (412), Expect = 4e-40
Identities = 107/306 (34%), Positives = 169/306 (54%), Gaps = 23/306 (7%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQ-PFSRSMFVTRTLRELKLLKFFHSHEN 71
+ ++ ++GEG YG V A K T VA+KK++ + F +RE+K+L+ H +
Sbjct: 727 FDIIGIIGEGTYGQVYKARDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQL-IHRS 785
Query: 72 IISVLDIVRPTS----WHKFE-AVYLVQELMETDLQKIINQQ--NLSEDHIQYFVYQILR 124
++++ +IV + K + A YLV E M+ DL ++ + SEDHI+ F+ Q++
Sbjct: 786 VVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLME 845
Query: 125 ALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATR 184
L+ H +HRD+K SN+LLN++ +K+ DFGLAR L +S++SR T V T
Sbjct: 846 GLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLAR-LYNSEESRP-----YTNKVITL 899
Query: 185 WYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLED 244
WYR PE++L + YT A+D+WSCGCIL E+ KP+F QL +I + GSP
Sbjct: 900 WYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAV 959
Query: 245 FEQIKSKRAKEYISQLPMKKGIPWANVLNKE---VNPLAIDLLSKMLTFNPDKRISAVEA 301
+ + Y + + KK + L +E + A+DLL MLT +P KR +A +
Sbjct: 960 WPDVIK---LPYFNTMKPKK--QYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQT 1014
Query: 302 LEHPYL 307
L+ +L
Sbjct: 1015 LQSDFL 1020
>At3g54180 [R] KOG0594 Protein kinase PCTAIRE and related kinases
Length = 309
Score = 163 bits (412), Expect = 4e-40
Identities = 107/308 (34%), Positives = 161/308 (51%), Gaps = 25/308 (8%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQ-PFSRSMFVTRTLRELKLLKFFHSHEN 71
Y+ ++ VGEG YG V A+ K T VA+KK + LRE+ LL+ +
Sbjct: 4 YEKLEKVGEGTYGKVYKAMEKGTGKLVALKKTRLEMDEEGIPPTALREISLLQMLSTSIY 63
Query: 72 IISVL---DIVRPT--SWHKFEAVYLVQELMETDLQKII-------NQQNLSEDHIQYFV 119
++ +L + +P+ S +YLV E ++TDL+K I N + L IQ +
Sbjct: 64 VVRLLCVEHVHQPSTKSQSTKSNLYLVFEYLDTDLKKFIDSYRKGPNPKPLEPFLIQKLM 123
Query: 120 YQILRALKSLHSAQVIHRDLKPSNLLLNSNCDL-KVCDFGLARCLASSDQSRENMVGFMT 178
+Q+ + + HS V+HRDLKP NLLL + +L K+ D GL R +S T
Sbjct: 124 FQLCKGVAHCHSHGVLHRDLKPQNLLLVKDKELLKIADLGLGRAFTVPLKS-------YT 176
Query: 179 EYVATRWYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLG 238
+ T WYRAPE++L Y+T +D+WS GCI AEM+ + LFPG QL I +LG
Sbjct: 177 HEIVTLWYRAPEVLLGSTHYSTGVDMWSVGCIFAEMVRRQALFPGDSEFQQLLHIFRLLG 236
Query: 239 SPTLEDFEQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISA 298
+PT + + + + R + + + ++P +DLL+KML +NP +RISA
Sbjct: 237 TPTEQQWPGVSTLRDWHVYPKWEPQD----LTLAVPSLSPQGVDLLTKMLKYNPAERISA 292
Query: 299 VEALEHPY 306
AL+HPY
Sbjct: 293 KTALDHPY 300
>SPBC32H8.10 [D] KOG0600 Cdc2-related protein kinase
Length = 591
Score = 162 bits (411), Expect = 5e-40
Identities = 116/348 (33%), Positives = 177/348 (50%), Gaps = 30/348 (8%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFS-RSMFVTRTLRELKLLKFFHSHEN 71
Y L++ +GEG +G V + + A+K+I + + F +RE+K+LK HEN
Sbjct: 36 YHLMEKLGEGTFGEVYKSQRRKDGKVYALKRILMHTEKEGFPITAIREIKILKSI-KHEN 94
Query: 72 IISVLD--IVRPTSWHKFE-AVYLVQELMETDLQKIINQQNL--SEDHIQYFVYQILRAL 126
II + D +VR H+ ++Y+V M+ DL ++ ++ +E I+ ++ Q+
Sbjct: 95 IIPLSDMTVVRADKKHRRRGSIYMVTPYMDHDLSGLLENPSVKFTEPQIKCYMKQLFAGT 154
Query: 127 KSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGF-------MTE 179
K LH ++HRDLK +NLL++++ LK+ DFGLAR + + +N G T
Sbjct: 155 KYLHDQLILHRDLKAANLLIDNHGILKIADFGLARVITEESYANKNP-GLPPPNRREYTG 213
Query: 180 YVATRWYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGS 239
V TRWYR+PE++L + YTTA+D+WS GCI+AEM G+P+ G QL I + GS
Sbjct: 214 CVVTRWYRSPELLLGERRYTTAIDMWSVGCIMAEMYKGRPILQGSSDLDQLDKIFRLCGS 273
Query: 240 PTLEDFEQIKSKRAKEYISQLPM-KKGIPWA-NVLNKEVNPLAIDLLSKMLTFNPDKRIS 297
PT + E + P + + A KE+ L +LT NPD+R+S
Sbjct: 274 PTQATMPNWEKLPGCEGVRSFPSHPRTLETAFFTFGKEMT----SLCGAILTLNPDERLS 329
Query: 298 AVEALEHPYLATYHDPDDEPDYPQLNLEDNFWKIDNE--ARDKNEEDD 343
A ALEH Y T P YP E + +E R K E+ D
Sbjct: 330 ASMALEHEYFTT-------PPYPANPSELQSYSASHEYDKRRKREQRD 370
>Hs14110390 [D] KOG0600 Cdc2-related protein kinase
Length = 1452
Score = 162 bits (411), Expect = 5e-40
Identities = 107/306 (34%), Positives = 168/306 (53%), Gaps = 23/306 (7%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQ-PFSRSMFVTRTLRELKLLKFFHSHEN 71
+ ++ ++GEG YG V A K T VA+KK++ + F +RE+K+L+ +H++
Sbjct: 705 FDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQL-THQS 763
Query: 72 IISVLDIVRPTS----WHKFE-AVYLVQELMETDLQKIINQQ--NLSEDHIQYFVYQILR 124
II++ +IV + K + A YLV E M+ DL ++ + +E+HI+ F+ Q++
Sbjct: 764 IINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLME 823
Query: 125 ALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATR 184
L H +HRD+K SN+LLN+ +K+ DFGLAR L SS++SR T V T
Sbjct: 824 GLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLAR-LYSSEESRP-----YTNKVITL 877
Query: 185 WYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLED 244
WYR PE++L + YT A+D+WSCGCIL E+ KP+F QL +I + GSP
Sbjct: 878 WYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAV 937
Query: 245 FEQIKSKRAKEYISQLPMKKGIPWANVLNKE---VNPLAIDLLSKMLTFNPDKRISAVEA 301
+ + Y + + KK + L +E + A+DL ML +P KR +A +A
Sbjct: 938 WPDVIK---LPYFNTMKPKK--QYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQA 992
Query: 302 LEHPYL 307
L+ +L
Sbjct: 993 LQCEFL 998
>Hs14110387 [D] KOG0600 Cdc2-related protein kinase
Length = 1512
Score = 162 bits (411), Expect = 5e-40
Identities = 107/306 (34%), Positives = 168/306 (53%), Gaps = 23/306 (7%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQ-PFSRSMFVTRTLRELKLLKFFHSHEN 71
+ ++ ++GEG YG V A K T VA+KK++ + F +RE+K+L+ +H++
Sbjct: 705 FDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQL-THQS 763
Query: 72 IISVLDIVRPTS----WHKFE-AVYLVQELMETDLQKIINQQ--NLSEDHIQYFVYQILR 124
II++ +IV + K + A YLV E M+ DL ++ + +E+HI+ F+ Q++
Sbjct: 764 IINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLME 823
Query: 125 ALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATR 184
L H +HRD+K SN+LLN+ +K+ DFGLAR L SS++SR T V T
Sbjct: 824 GLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLAR-LYSSEESRP-----YTNKVITL 877
Query: 185 WYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLED 244
WYR PE++L + YT A+D+WSCGCIL E+ KP+F QL +I + GSP
Sbjct: 878 WYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAV 937
Query: 245 FEQIKSKRAKEYISQLPMKKGIPWANVLNKE---VNPLAIDLLSKMLTFNPDKRISAVEA 301
+ + Y + + KK + L +E + A+DL ML +P KR +A +A
Sbjct: 938 WPDVIK---LPYFNTMKPKK--QYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQA 992
Query: 302 LEHPYL 307
L+ +L
Sbjct: 993 LQCEFL 998
>Hs16160923 [R] KOG0594 Protein kinase PCTAIRE and related kinases
Length = 472
Score = 162 bits (409), Expect = 9e-40
Identities = 102/302 (33%), Positives = 160/302 (52%), Gaps = 29/302 (9%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTLRELKLLKFFHSHENI 72
Y +D +GEG Y TV K T VA+K+I+ +RE+ LLK H NI
Sbjct: 142 YVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKNL-KHANI 200
Query: 73 ISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQN--LSEDHIQYFVYQILRALKSLH 130
+++ D++ H ++ LV E +++DL++ ++ +S +++ F++Q+LR L H
Sbjct: 201 VTLHDLI-----HTDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCH 255
Query: 131 SAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRAPE 190
+++HRDLKP NLL+N +LK+ DFGLAR + ++ N V T WYR P+
Sbjct: 256 HRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEV-------VTLWYRPPD 308
Query: 191 IMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLED------ 244
++L EY+T +D+W GCI EM G+PLFPG +L +I +LG+PT E
Sbjct: 309 VLLGSTEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTA 368
Query: 245 FEQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEH 304
F + ++ Y+ Q P+ P ++ I LLS +L + R+SA AL H
Sbjct: 369 FSEFRTYSFPCYLPQ-PLINHAP-------RLDTDGIHLLSSLLLYESKSRMSAEAALSH 420
Query: 305 PY 306
Y
Sbjct: 421 SY 422
>7292375 [R] KOG0594 Protein kinase PCTAIRE and related kinases
Length = 509
Score = 162 bits (409), Expect = 9e-40
Identities = 107/318 (33%), Positives = 164/318 (50%), Gaps = 33/318 (10%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTLRELKLLKFFHSHENI 72
Y ++ +GEG+Y TV K T +VA+K+I+ +RE LLK H NI
Sbjct: 192 YVKLEPLGEGSYATVYKGFSKLTYQRVALKEIRLQEEEGAPFTAIREASLLKEL-KHSNI 250
Query: 73 ISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQNLSEDH--IQYFVYQILRALKSLH 130
+++ DIV H E + V E + TDL + + + DH ++ F++Q+LR L H
Sbjct: 251 VTLHDIV-----HTRETLTFVFEYVNTDLSQYMEKHPGGLDHRNVRLFLFQLLRGLSYCH 305
Query: 131 SAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRAPE 190
+V+HRD+KP NLL++ +LK+ DFGLAR + + + V T WYR P+
Sbjct: 306 KRRVLHRDVKPQNLLISDCGELKLADFGLARAKSVPSHT-------YSHEVVTLWYRPPD 358
Query: 191 IMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPG-KDYHHQLWIILEVLGSPTLEDFEQIK 249
++L EY+T++D+W GCI EM+ G P FPG +D + QL I ++LG+PT + + +
Sbjct: 359 VLLGSTEYSTSLDMWGVGCIFVEMVTGMPTFPGIRDTYDQLDKIFKLLGTPTEDTWPGV- 417
Query: 250 SKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLL------SKMLTFNPDKRISAVEALE 303
+ P K G L P D++ + L NP++R+ A +AL+
Sbjct: 418 ----THFPGYKPHKLGFYRPRKLGHNF-PRLYDIIEGETIANGFLQLNPEQRLGADDALQ 472
Query: 304 HPYLA-----TYHDPDDE 316
HPY A Y PD E
Sbjct: 473 HPYFAQLPKKLYELPDGE 490
>7300650 [R] KOG0594 Protein kinase PCTAIRE and related kinases
Length = 314
Score = 160 bits (406), Expect = 2e-39
Identities = 103/309 (33%), Positives = 169/309 (54%), Gaps = 21/309 (6%)
Query: 9 IPSHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRT-LRELKLLKFFH 67
I ++Q + +GEG YG V A T VA+KKI+ + V T +RE+ LLK
Sbjct: 4 ILDNFQRAEKIGEGTYGIVYKARSNSTGQDVALKKIRLEGETEGVPSTAIREISLLKNL- 62
Query: 68 SHENIISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQN--LSEDHIQYFVYQILRA 125
H N++ + D+V + +Y++ E + DL+K+++++ + I+ +++QIL A
Sbjct: 63 KHPNVVQLFDVVISGN-----NLYMIFEYLNMDLKKLMDKKKDVFTPQLIKSYMHQILDA 117
Query: 126 LKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRW 185
+ H+ +++HRDLKP NLL+++ +K+ DFGLAR ++ T V T W
Sbjct: 118 VGFCHTNRILHRDLKPQNLLVDTAGKIKLADFGLARAFNVPMRA-------YTHEVVTLW 170
Query: 186 YRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDF 245
YRAPEI+L + Y+T +DIWS GCI +EMIM + LFPG QL+ I L +P ++
Sbjct: 171 YRAPEILLGTKFYSTGVDIWSLGCIFSEMIMRRSLFPGDSEIDQLYRIFRTLSTPDETNW 230
Query: 246 EQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEHP 305
+ + ++ ++ P +G N+ A +L+ ML ++P+ RISA +AL+H
Sbjct: 231 PGV--TQLPDFKTKFPRWEG---TNMPQPITEHEAHELIMSMLCYDPNLRISAKDALQHA 285
Query: 306 YLATYHDPD 314
Y D
Sbjct: 286 YFRNVQHVD 294
>YPR161c [D] KOG0600 Cdc2-related protein kinase
Length = 657
Score = 160 bits (405), Expect = 3e-39
Identities = 104/326 (31%), Positives = 169/326 (50%), Gaps = 20/326 (6%)
Query: 11 SHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKI-QPFSRSMFVTRTLRELKLLKFFHSH 69
+HY+ + +G+G +G V IH T +VA+KKI + +F RE+ +LK + H
Sbjct: 58 NHYREDEKLGQGTFGEVYKGIHLETQRQVAMKKIIVSVEKDLFPITAQREITILKRLN-H 116
Query: 70 ENIISVL--------DIVRPTSWHKFEAVYLVQELMETDLQKIINQQ--NLSEDHIQYFV 119
+NII ++ DI S + ++ Y++ M DL +++ NL I+ +
Sbjct: 117 KNIIKLIEMVYDHSPDITNAASSNLHKSFYMILPYMVADLSGVLHNPRINLEMCDIKNMM 176
Query: 120 YQILRALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGF--- 176
QIL L +H A+ +HRD+K +N+L++ N LK+ DFGLAR + + G
Sbjct: 177 LQILEGLNYIHCAKFMHRDIKTANILIDHNGVLKLADFGLARLYYGCPPNLKYPGGAGSG 236
Query: 177 --MTEYVATRWYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIIL 234
T V TRWYRAPE++L ++YTTA+DIW GC+ AE KP+ GK Q +I
Sbjct: 237 AKYTSVVVTRWYRAPELVLGDKQYTTAVDIWGVGCVFAEFFEKKPILQGKTDIDQGHVIF 296
Query: 235 EVLGSPTLEDFEQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDK 294
++LG+PT ED+ + E ++ K + K ++ +D L ++L +P K
Sbjct: 297 KLLGTPTEEDWAVARYLPGAE-LTTTNYKPTL--RERFGKYLSETGLDFLGQLLALDPYK 353
Query: 295 RISAVEALEHPYLATYHDPDDEPDYP 320
R++A+ A HP+ P ++ P
Sbjct: 354 RLTAMSAKHHPWFKEDPLPSEKITLP 379
>HsM4504163 [G] KOG0658 Glycogen synthase kinase-3
Length = 420
Score = 160 bits (405), Expect = 3e-39
Identities = 102/310 (32%), Positives = 165/310 (52%), Gaps = 26/310 (8%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTLRELKLLKFFHSHENI 72
Y ++G G++G V A + VAIKK+ R F R L+ ++ L H NI
Sbjct: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKR--FKNRELQIMRKL----DHCNI 109
Query: 73 ISVLDIVRPTSWHKFEAVYL--VQELMETDLQKIIN-----QQNLSEDHIQYFVYQILRA 125
+ L +S K + VYL V + + + ++ +Q L +++ ++YQ+ R+
Sbjct: 110 VR-LRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRS 168
Query: 126 LKSLHSAQVIHRDLKPSNLLLNSNCD-LKVCDFGLARCLASSDQSRENMVGFMTEYVATR 184
L +HS + HRD+KP NLLL+ + LK+CDFG A+ L + + Y+ +R
Sbjct: 169 LAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPN--------VSYICSR 220
Query: 185 WYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLED 244
+YRAPE++ +YT+++D+WS GC+LAE+++G+P+FPG QL I++VLG+PT
Sbjct: 221 YYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTR-- 278
Query: 245 FEQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEH 304
EQI+ + P K PW V P AI L S++L + P R++ +EA H
Sbjct: 279 -EQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAH 337
Query: 305 PYLATYHDPD 314
+ DP+
Sbjct: 338 SFFDELRDPN 347
>7296451 [D] KOG0600 Cdc2-related protein kinase
Length = 1157
Score = 160 bits (405), Expect = 3e-39
Identities = 117/371 (31%), Positives = 184/371 (49%), Gaps = 57/371 (15%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQ-PFSRSMFVTRTLRELKLLKFFHSHEN 71
++++ +GEG YG V A TN VA+KK++ + F +RE+K+L+ + H N
Sbjct: 804 FEMIAQIGEGTYGQVYKARDHHTNDMVALKKVRLEHEKEGFPITAVREIKILRQLN-HRN 862
Query: 72 IISVLDIVRPTSWHKFEAV---------YLVQELMETDLQKIINQQ--NLSEDHIQYFVY 120
I+++ +IV K +AV YLV E M+ DL ++ + +E++ +
Sbjct: 863 IVNLHEIVTD----KQDAVEFRKDKGSFYLVFEYMDHDLMGLLESGMVDFNEENNASIMK 918
Query: 121 QILRALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEY 180
Q+L L H +HRD+K SN+L+N+ +K+ DFGLAR + D+ R T
Sbjct: 919 QLLDGLNYCHKKNFLHRDIKCSNILMNNRGKVKLADFGLARLYNADDRERP-----YTNK 973
Query: 181 VATRWYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSP 240
V T WYR PE++L + Y ++D+WSCGCIL E+ + +PLF QL I ++ GSP
Sbjct: 974 VITLWYRPPELLLGEERYGPSIDVWSCGCILGELFVKRPLFQANAEMAQLETISKICGSP 1033
Query: 241 T---------LEDFEQIKSK-----RAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSK 286
L F +K K R +E +P A+DLL K
Sbjct: 1034 VPAVWPNVIKLPLFHTLKQKKTHRRRLREDFEFMPAP----------------ALDLLDK 1077
Query: 287 MLTFNPDKRISAVEALEHPYLATYHDPDDEPDYPQL-NLED--NFWKIDNEARDKNEEDD 343
ML +PDKRI+A +AL P+L +PD+ P PQL +D W + + +++
Sbjct: 1078 MLDLDPDKRITAEDALRSPWLRKI-NPDEMPT-PQLPTWQDCHELWSKKRRRQMREQQES 1135
Query: 344 IPLELLKKMLY 354
+P ++ Y
Sbjct: 1136 LPPTVIASTKY 1146
>Hs11496279 [T] KOG0661 MAPK related serine/threonine protein kinase
Length = 623
Score = 160 bits (404), Expect = 4e-39
Identities = 101/301 (33%), Positives = 164/301 (53%), Gaps = 24/301 (7%)
Query: 11 SHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTLRELKLLKFFHSHE 70
+ Y + +G+G YG+V + VAIK+++ S LRE+K LK + H
Sbjct: 2 NRYTTMRQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWDECMNLREVKSLKKLN-HA 60
Query: 71 NIISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQN--LSEDHIQYFVYQILRALKS 128
N+I + +++R + +Y + E M+ +L +++ +N E I+ +YQIL+ L
Sbjct: 61 NVIKLKEVIREN-----DHLYFIFEYMKENLYQLMKDRNKLFPESVIRNIMYQILQGLAF 115
Query: 129 LHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRA 188
+H HRD+KP NLL +K+ DFGLAR L S T+YV+TRWYRA
Sbjct: 116 IHKHGFFHRDMKPENLLCMGPELVKIADFGLARELRSQPP--------YTDYVSTRWYRA 167
Query: 189 PEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFE-- 246
PE++L Y++ +D+W+ G I+AE+ M +PLFPG +++ I +VLG+P D+
Sbjct: 168 PEVLLRSSVYSSPIDVWAVGSIMAELYMLRPLFPGTSEVDEIFKICQVLGTPKKSDWPEG 227
Query: 247 -QIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEHP 305
Q+ S + +P+ N N+ AI L+++ML ++P KR +A +AL+HP
Sbjct: 228 YQLASSMNFRFPQCVPINLKTLIPNASNE-----AIQLMTEMLNWDPKKRPTASQALKHP 282
Query: 306 Y 306
Y
Sbjct: 283 Y 283
>CE00315 [R] KOG0594 Protein kinase PCTAIRE and related kinases
Length = 332
Score = 160 bits (404), Expect = 4e-39
Identities = 102/302 (33%), Positives = 166/302 (54%), Gaps = 26/302 (8%)
Query: 16 VDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRT-LRELKLLKFFHSHENIIS 74
++ +GEG YG V ++ TN VA+KKI+ S V T +RE+ LLK H N++
Sbjct: 25 LEKIGEGTYGVVYKGKNRRTNAMVAMKKIRLESEDEGVPSTAVREISLLKELQ-HPNVVG 83
Query: 75 VLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQNLSE----DHIQYFVYQILRALKSLH 130
+ ++ + ++L+ E + DL++ ++Q E + ++ + +QIL+A+ H
Sbjct: 84 LEAVIMQEN-----RLFLIFEFLSFDLKRYMDQLGKDEYLPLETLKSYTFQILQAMCFCH 138
Query: 131 SAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRAPE 190
+VIHRDLKP NLL+++N +K+ DFGLAR + + T V T WYRAPE
Sbjct: 139 QRRVIHRDLKPQNLLVDNNGAIKLADFGLARAIGIP-------IRVYTHEVVTLWYRAPE 191
Query: 191 IMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQIKS 250
I++ Q Y+ +D+WS GCI AEM KPLF G +L+ I VLG+PT ++ ++S
Sbjct: 192 ILMGAQRYSMGVDMWSIGCIFAEMATKKPLFQGDSEIDELFRIFRVLGTPTELEWNGVES 251
Query: 251 KRAKEYISQLP-MKKGIPWANVLNKE-----VNPLAIDLLSKMLTFNPDKRISAVEALEH 304
+Y + P ++ +K+ ++ A LL +L ++P R++A +AL H
Sbjct: 252 --LPDYKATFPKWRENFLRDKFYDKKTGKHLLDDTAFSLLEGLLIYDPSLRLNAKKALVH 309
Query: 305 PY 306
PY
Sbjct: 310 PY 311
>At5g45430 [T] KOG0661 MAPK related serine/threonine protein kinase
Length = 530
Score = 160 bits (404), Expect = 4e-39
Identities = 103/313 (32%), Positives = 175/313 (55%), Gaps = 30/313 (9%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTN--------TKVAIKKIQPFSRSMFVTRTLRELKLLK 64
Y L+ VG+G +G V A++K TN +VAIK+++ S LRE+K L
Sbjct: 4 YTLLKEVGDGTFGNVWRAVNKQTNEVGTEVFYVQVAIKRMKKKYFSWEECVNLREVKSLS 63
Query: 65 FFHSHENIISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQ--NLSEDHIQYFVYQI 122
+ H NI+ + +++R + +Y V E ME +L +++ + + +E I+ + +Q+
Sbjct: 64 RMN-HPNIVKLKEVIREN-----DILYFVFEYMECNLYQLMKDRPKHFAESDIRNWCFQV 117
Query: 123 LRALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVA 182
+ L +H HRDLKP NLL++ + +K+ D GLAR + SS TEYV+
Sbjct: 118 FQGLSYMHQRGYFHRDLKPENLLVSKDV-IKIADLGLAREIDSSPP--------YTEYVS 168
Query: 183 TRWYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTL 242
TRWYRAPE++L YT+ +D+W+ G I+AE++ +PLFPG +++ I V+GSPT
Sbjct: 169 TRWYRAPEVLLQSYVYTSKVDMWAMGAIMAELLSLRPLFPGASEADEIYKICSVIGSPTE 228
Query: 243 EDF-EQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEA 301
E + E + Y Q P G+ ++V+ + A++L+ ++ +++P R + EA
Sbjct: 229 ETWLEGLNLASVINY--QFPQFPGVHLSSVM-PYASADAVNLIERLCSWDPCNRPTTAEA 285
Query: 302 LEHPYL-ATYHDP 313
L+HP+ + Y+ P
Sbjct: 286 LQHPFFQSCYYIP 298
>7290342 [G] KOG0658 Glycogen synthase kinase-3
Length = 1008
Score = 160 bits (404), Expect = 4e-39
Identities = 103/302 (34%), Positives = 162/302 (53%), Gaps = 26/302 (8%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTLRELKLLKFFHSHENI 72
Y ++G G++G V A T VAIKK+ R F R L+ ++ L+ H NI
Sbjct: 548 YTDTKVIGNGSFGVVFQAKLCDTGELVAIKKVLQDRR--FKNRELQIMRKLE----HCNI 601
Query: 73 ISVLDIVRPTSWHKFEAVYL--VQELMETDLQKIINQ-----QNLSEDHIQYFVYQILRA 125
+ +L +S K + V+L V E + + K+ Q Q + + I+ ++YQ+ R+
Sbjct: 602 VKLLYFFY-SSGEKRDEVFLNLVLEYIPETVYKVARQYAKTKQTIPINFIRLYMYQLFRS 660
Query: 126 LKSLHSAQVIHRDLKPSNLLLN-SNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATR 184
L +HS + HRD+KP NLLL+ LK+CDFG A+ L + + Y+ +R
Sbjct: 661 LAYIHSLGICHRDIKPQNLLLDPETAVLKLCDFGSAKQLLHGEPN--------VSYICSR 712
Query: 185 WYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLED 244
+YRAPE++ YTT +D+WS GC+LAE+++G+P+FPG QL +++VLG+PT
Sbjct: 713 YYRAPELIFGAINYTTKIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEVIKVLGTPTR-- 770
Query: 245 FEQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEH 304
EQI+ + P K PW V AI+L+S +L + P RI+ ++A H
Sbjct: 771 -EQIREMNPNYTEFKFPQIKSHPWQKVFRIRTPTEAINLVSLLLEYTPSARITPLKACAH 829
Query: 305 PY 306
P+
Sbjct: 830 PF 831
>CE21401 [G] KOG0658 Glycogen synthase kinase-3
Length = 362
Score = 159 bits (402), Expect = 6e-39
Identities = 99/305 (32%), Positives = 164/305 (53%), Gaps = 26/305 (8%)
Query: 18 LVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTLRELKLLKFFHSHENIISVLD 77
++G G++G V A TN VAIKK+ R F R L+ ++ L +H NI+ L
Sbjct: 41 VIGNGSFGVVFLAKLSTTNEMVAIKKVLQDKR--FKNRELQIMRKL----NHPNIVK-LK 93
Query: 78 IVRPTSWHKFEAVYL--VQELMETDLQKIIN-----QQNLSEDHIQYFVYQILRALKSLH 130
+S K + +YL + E + + ++ +Q + +++ ++YQ+LR+L +H
Sbjct: 94 YFFYSSGEKKDELYLNLILEYVPETVYRVARHYSKQRQQIPMIYVKLYMYQLLRSLAYIH 153
Query: 131 SAQVIHRDLKPSNLLLNSNCD-LKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRAP 189
S + HRD+KP NLL++ LK+CDFG A+ L ++ + Y+ +R+YRAP
Sbjct: 154 SIGICHRDIKPQNLLIDPESGVLKLCDFGSAKYLVRNEPN--------VSYICSRYYRAP 205
Query: 190 EIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQIK 249
E++ YT ++D+WS G ++AE+++G+P+FPG QL I++VLG+PT EQI+
Sbjct: 206 ELIFGATNYTNSIDVWSAGTVMAELLLGQPIFPGDSGVDQLVEIIKVLGTPTR---EQIQ 262
Query: 250 SKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEHPYLAT 309
S + P K PW V AIDL+SK++ + P R + A +H +
Sbjct: 263 SMNPNYKEFKFPQIKAHPWNKVFRVHTPAEAIDLISKIIEYTPTSRPTPQAACQHAFFDE 322
Query: 310 YHDPD 314
+PD
Sbjct: 323 LRNPD 327
>CE12408 [T] KOG0661 MAPK related serine/threonine protein kinase
Length = 527
Score = 159 bits (402), Expect = 6e-39
Identities = 98/301 (32%), Positives = 168/301 (55%), Gaps = 28/301 (9%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTLRELKLLKFFHSHENI 72
Y + +G+G +G V A T +VAIK+++ S +LRE+K LK + H NI
Sbjct: 45 YLMTKRLGDGTFGEVMLAKKIDTGDRVAIKRMKKKFYSWEEAMSLREVKSLKKLN-HPNI 103
Query: 73 ISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQN--LSEDHIQYFVYQILRALKSLH 130
I + +++R + +Y V E M+ +L +++ ++ E I+ +YQ+L+ L +H
Sbjct: 104 IKLREVIREN-----DILYFVFEFMQENLYELMKDRDRYFPESVIRNIIYQVLQGLAFMH 158
Query: 131 SAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRAPE 190
HRD+KP N++ N +K+ DFGLAR + S T+YV+TRWYRAPE
Sbjct: 159 KNGFFHRDMKPENIMCNGTELVKIADFGLAREIRSKPP--------YTDYVSTRWYRAPE 210
Query: 191 IMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDF-EQIK 249
I+L Y + +D+W+ GCI+AE+ + +PLFPG QL+ I+ +LG+P +++ E +
Sbjct: 211 ILLRSTSYNSPIDMWALGCIMAELYILRPLFPGTSEMDQLFKIISILGTPNKDEWPEGYQ 270
Query: 250 SKRAKEY----ISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEHP 305
A + + PM++ + N ++KE + L+ M+ +NP+KR +A ++L +
Sbjct: 271 LASAMNFRFQQVVATPMEQVV---NTISKE----GMKLMMDMMLWNPEKRPNANQSLRYK 323
Query: 306 Y 306
Y
Sbjct: 324 Y 324
>SPBC8D2.01 [G] KOG0658 Glycogen synthase kinase-3
Length = 381
Score = 159 bits (401), Expect = 8e-39
Identities = 102/309 (33%), Positives = 162/309 (52%), Gaps = 24/309 (7%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTLRELKLLKFFHSHENI 72
Y+ ++G G++G V A T +A+K++ R REL++++ SH NI
Sbjct: 25 YEPCRVLGSGSFGVVIQAKLVGTPGFIAVKRVLQDKRYKN-----RELQIMRAI-SHPNI 78
Query: 73 ISVLDIVRPTSWHKFEA--VYLVQELMETDLQKII----NQQNLSEDHIQYFVYQILRAL 126
I ++ + K E L++ + ET + ++++ I+ + +Q+ RAL
Sbjct: 79 IKLIAFFHTHNPSKDETHLCLLLEYMPETVFDDMRWYTRRRKSIPNLSIKLYAFQLFRAL 138
Query: 127 KSLHSAQVIHRDLKPSNLLLNSNCD-LKVCDFGLARCLASSDQSRENMVGFMTEYVATRW 185
LHS V HRD+KP NLL++ LK+CDFG A+ L S+ + Y+ +R+
Sbjct: 139 AYLHSTGVCHRDIKPQNLLVDYKTGILKLCDFGSAKVLVPSEPN--------VSYICSRY 190
Query: 186 YRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDF 245
YRAPE++ YTT +D+WS C++AE+ +G+PLFPG QL I+ VLG+P+ +
Sbjct: 191 YRAPELVFGATHYTTKIDVWSAACVIAELFIGRPLFPGDSSVEQLVEIIRVLGTPS---Y 247
Query: 246 EQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEHP 305
+I LP + +V+ A+DLL KMLT+ P KRISA+E L HP
Sbjct: 248 HEISVMNPNYVNHSLPNVRPHTLESVMPHNCTKNAMDLLHKMLTYVPSKRISAIEVLTHP 307
Query: 306 YLATYHDPD 314
+ DP+
Sbjct: 308 FFDELRDPN 316
>Hs6912584 [R] KOG0594 Protein kinase PCTAIRE and related kinases
Length = 451
Score = 159 bits (401), Expect = 8e-39
Identities = 108/300 (36%), Positives = 155/300 (51%), Gaps = 18/300 (6%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTLRELKLLKFFHSHENI 72
Y+ ++ +GEG+Y TV K VA+K I+ +RE LLK H NI
Sbjct: 117 YEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEEEGTPFTAIREASLLKGL-KHANI 175
Query: 73 ISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQ--NLSEDHIQYFVYQILRALKSLH 130
+ + DI+ H E + LV E + TDL + +++ L D+++ F++Q+LR L +H
Sbjct: 176 VLLHDII-----HTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIH 230
Query: 131 SAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRAPE 190
++HRDLKP NLL++ +LK+ DFGLAR + + N V T WYR P+
Sbjct: 231 QRYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSN-------EVVTLWYRPPD 283
Query: 191 IMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPG-KDYHHQLWIILEVLGSPTLEDFEQIK 249
++L EY+T +D+W GCI EMI G FPG KD QL I VLG+P + + +
Sbjct: 284 VLLGSTEYSTCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVH 343
Query: 250 S-KRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEHPYLA 308
S K L K + A VN A DL SK+L +P R+SA AL H Y +
Sbjct: 344 SLPHFKPERFTLYSSKNLRQAWNKLSYVNH-AEDLASKLLQCSPKNRLSAQAALSHEYFS 402
>ECU08g1920 [R] KOG0594 Protein kinase PCTAIRE and related kinases
Length = 296
Score = 158 bits (400), Expect = 1e-38
Identities = 94/300 (31%), Positives = 163/300 (54%), Gaps = 23/300 (7%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFV-TRTLRELKLLKFFHSHEN 71
+Q ++ +GEG YG V A + TN VA+KKI+ + + + T+RE+ LLK H
Sbjct: 5 FQKLEKIGEGTYGVVYKARERNTNRVVALKKIRLENENEGIPATTIREILLLKNL-KHST 63
Query: 72 IISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQN-----LSEDHIQYFVYQILRAL 126
I+ + D++ + +YLV E +E DL++ +++ + + E ++ Q+L A+
Sbjct: 64 IVELSDVI-----YNNNKMYLVFEYVELDLRRYLDRMSDEGRLVEEGFVRKMSQQLLTAM 118
Query: 127 KSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWY 186
+ HS + HRDLKP N+L++ ++K+ DFGL R ++ T V T WY
Sbjct: 119 EYCHSRNIFHRDLKPQNILVDPKENIKLADFGLGRAAGIPLRT-------YTTEVVTLWY 171
Query: 187 RAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFE 246
R PE++L + Y ++D+WS CI+AE+++ +P FPG QL+ I +VLG+P +
Sbjct: 172 RPPELLLGCKYYDASVDVWSAACIMAEVVLMRPFFPGDSEIDQLFRIFKVLGTPNNSRWS 231
Query: 247 QIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEHPY 306
+++ Y + P+ + + + P +DL+SKML ++P R++A L H Y
Sbjct: 232 NVEN--FPNYKVEFPVWDPVDLKTIFRGD--PDFVDLISKMLEYDPKMRMTAKNGLSHKY 287
>YDL108w [DKL] KOG0659 Cdk activating kinase (CAK)/RNA polymerase II
transcription initiation/nucleotide excision repair
factor TFIIH/TFIIK kinase subunit CDK7
Length = 306
Score = 158 bits (399), Expect = 1e-38
Identities = 100/303 (33%), Positives = 158/303 (52%), Gaps = 23/303 (7%)
Query: 19 VGEGAYGTVCSAIHKPTNTKVAIKKIQPFS-RSMFVTRTLRELKLLKFFHSHENIISVLD 77
VGEG Y V T K+AIK+I+ + +RE+K L+ H N+I ++D
Sbjct: 13 VGEGTYAVVYLGCQHSTGRKIAIKEIKTSEFKDGLDMSAIREVKYLQEMQ-HPNVIELID 71
Query: 78 IVRPTSWHKFEAVYLVQELMETDLQKIINQQNL--SEDHIQYFVYQILRALKSLHSAQVI 135
I + ++ + LV E + TDL+ +I +++ + I+ ++ LR + H ++
Sbjct: 72 I-----FMAYDNLNLVLEFLPTDLEVVIKDKSILFTPADIKAWMLMTLRGVYHCHRNFIL 126
Query: 136 HRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRAPEIMLSF 195
HRDLKP+NLL + + +KV DFGLAR + + + +T V TRWYRAPE++
Sbjct: 127 HRDLKPNNLLFSPDGQIKVADFGLARAIPAPHE-------ILTSNVVTRWYRAPELLFGA 179
Query: 196 QEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQIKSKRAKE 255
+ YT+A+DIWS G I AE+++ P PG++ Q+ + LG+PT D+ ++ S
Sbjct: 180 KHYTSAIDIWSVGVIFAELMLRIPYLPGQNDVDQMEVTFRALGTPTDRDWPEVSSFMTYN 239
Query: 256 YISQLPMKKGIPWANVLNKE---VNPLAIDLLSKMLTFNPDKRISAVEALEHPYLATYHD 312
+ P P + L K + A+D + MLT NP KR +AV+ LE Y
Sbjct: 240 KLQIYPP----PSRDELRKRFIAASEYALDFMCGMLTMNPQKRWTAVQCLESDYFKELPP 295
Query: 313 PDD 315
P D
Sbjct: 296 PSD 298
>Hs7706059 [R] KOG0593 Predicted protein kinase KKIAMRE
Length = 455
Score = 158 bits (399), Expect = 1e-38
Identities = 103/298 (34%), Positives = 157/298 (52%), Gaps = 20/298 (6%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTLRELKLLKFFHSHENI 72
Y+ + VGEG+YGTV HK T VAIK +RE+K LK FH HEN+
Sbjct: 4 YETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKFLKQFH-HENL 62
Query: 73 ISVLDIVRPTSWHKFEAVYLVQELME-TDLQKIINQ-QNLSEDHIQYFVYQILRALKSLH 130
++++++ R + ++LV E ++ T L ++ + L ++ +++QILRA+ LH
Sbjct: 63 VNLIEVFRQK-----KKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLH 117
Query: 131 SAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRAPE 190
S +IHRD+KP N+L++ + K+CDFG AR LA+ T+YVATRWYRAPE
Sbjct: 118 SNNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGD-------IYTDYVATRWYRAPE 170
Query: 191 IMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLG--SPTLEDFEQI 248
++L Y +DIW+ GC++ EM G P P L I+ +G SP L++
Sbjct: 171 LVLKDTSYGKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSK 230
Query: 249 KSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEHPY 306
A + Q+ K A ++N L D++ L +P RIS+ + L H Y
Sbjct: 231 SPIFAGVVLPQVQHPKN---ARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEY 285
>Hs4502747 [D] KOG0669 Cyclin T-dependent kinase CDK9
Length = 372
Score = 158 bits (399), Expect = 1e-38
Identities = 99/316 (31%), Positives = 172/316 (54%), Gaps = 14/316 (4%)
Query: 8 DIPSHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKI-QPFSRSMFVTRTLRELKLLKFF 66
D S Y+ + +G+G +G V A H+ T KVA+KK+ + F LRE+K+L+
Sbjct: 14 DEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLL 73
Query: 67 HSHENIISVLDIVRPTS--WHKFE-AVYLVQELMETDLQKIINQQ----NLSEDHIQYFV 119
HEN++++++I R + +++ + ++YLV + E DL +++ LSE I+ +
Sbjct: 74 -KHENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSE--IKRVM 130
Query: 120 YQILRALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTE 179
+L L +H +++HRD+K +N+L+ + LK+ DFGLAR + + S+ N T
Sbjct: 131 QMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRY---TN 187
Query: 180 YVATRWYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGS 239
V T WYR PE++L ++Y +D+W GCI+AEM P+ G HQL +I ++ GS
Sbjct: 188 RVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGS 247
Query: 240 PTLEDFEQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAV 299
T E + + + E + + +K + +P A+DL+ K+L +P +RI +
Sbjct: 248 ITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSD 307
Query: 300 EALEHPYLATYHDPDD 315
+AL H + + P D
Sbjct: 308 DALNHDFFWSDPMPSD 323
>CE29612 [R] KOG0594 Protein kinase PCTAIRE and related kinases
Length = 426
Score = 157 bits (398), Expect = 2e-38
Identities = 105/314 (33%), Positives = 169/314 (53%), Gaps = 26/314 (8%)
Query: 8 DIPSHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTLRELKLLKFFH 67
D+ Y+ +D +GEG+Y TV K + VA+K+I+ + +RE LL+
Sbjct: 103 DVNDLYKRIDKLGEGSYATVYKCESKLDGSIVALKEIKLQFQEGLPFTAIREASLLRNLR 162
Query: 68 SHENIISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQ--NLSEDHIQYFVYQILRA 125
H NI+S+ DI +++ + V E M+ DL K + Q L I+ ++Q+LR
Sbjct: 163 -HANIVSLHDI-----FYQHHQLTFVFEYMKMDLSKYLEQNVYGLDSIDIKLLLFQLLRG 216
Query: 126 LKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRW 185
L H +++HRDLKP NLLL+ + LK+ DFGLAR A S SR + V T W
Sbjct: 217 LDFCHRKKILHRDLKPQNLLLDEDGVLKLADFGLAR--AKSVPSRT-----YSHEVVTLW 269
Query: 186 YRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPG-KDYHH-----QLWIILEVLGS 239
YR P++++ +Y+T++D+W GCI AE+ G LFPG KD H+ QL +I + G+
Sbjct: 270 YRPPDVLMGSTDYSTSLDMWGVGCIFAEICTGAALFPGSKDSHYPGTKDQLDMIFSIRGT 329
Query: 240 PTLEDFEQIKSKRAKEYISQL-PMKKGIPW--ANVLNKEVNPLAIDLLSKMLTFNPDKRI 296
P + + ++K+ Y +L P + + + N + ++ +LL +L P+ R+
Sbjct: 330 PDEKKWPEVKT--LPGYTPELFPRYRELSFIAVNPMFTKILKTGQELLGMLLQLRPESRV 387
Query: 297 SAVEALEHPYLATY 310
SA A+ HPY A++
Sbjct: 388 SAASAMLHPYFASF 401
>Hs7662388 [T] KOG0661 MAPK related serine/threonine protein kinase
Length = 632
Score = 157 bits (396), Expect = 3e-38
Identities = 102/308 (33%), Positives = 163/308 (52%), Gaps = 28/308 (9%)
Query: 11 SHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTLRELKLLKFFHSHE 70
+ Y + +G+G YG+V + +AIKK++ S LRE+K LK + H
Sbjct: 2 NRYTTIRQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEECMNLREVKSLKKLN-HA 60
Query: 71 NIISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQN--LSEDHIQYFVYQILRALKS 128
N++ + +++R + +Y + E M+ +L ++I ++N E I+ +YQIL+ L
Sbjct: 61 NVVKLKEVIREN-----DHLYFIFEYMKENLYQLIKERNKLFPESAIRNIMYQILQGLAF 115
Query: 129 LHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRA 188
+H HRDLKP NLL +K+ DFGLAR + S T+YV+TRWYRA
Sbjct: 116 IHKHGFFHRDLKPENLLCMGPELVKIADFGLAREIRSKPP--------YTDYVSTRWYRA 167
Query: 189 PEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFE-- 246
PE++L Y++ +D+W+ GCI+AE+ +PLFPG ++ I +VLG+P D+
Sbjct: 168 PEVLLRSTNYSSPIDVWAVGCIMAEVYTLRPLFPGASEIDTIFKICQVLGTPKKTDWPEG 227
Query: 247 -QIKSKRAKEYISQLP--MKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALE 303
Q+ S + +P +K IP + A+ LL ML ++P KR +A +AL
Sbjct: 228 YQLSSAMNFRWPQCVPNNLKTLIP-------NASSEAVQLLRDMLQWDPKKRPTASQALR 280
Query: 304 HPYLATYH 311
+PY H
Sbjct: 281 YPYFQVGH 288
>Hs22051130 [G] KOG0658 Glycogen synthase kinase-3
Length = 483
Score = 157 bits (396), Expect = 3e-38
Identities = 100/302 (33%), Positives = 161/302 (53%), Gaps = 26/302 (8%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTLRELKLLKFFHSHENI 72
Y + ++G G++G V A T VAIKK+ R F R L+ ++ L H NI
Sbjct: 119 YTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKR--FKNRELQIMRKL----DHCNI 172
Query: 73 ISVLDIVRPTSWHKFEAVYL--VQELMETDLQKIINQQNLSED-----HIQYFVYQILRA 125
+ L +S K + +YL V E + + ++ ++ +++ ++YQ+ R+
Sbjct: 173 VR-LRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRS 231
Query: 126 LKSLHSAQVIHRDLKPSNLLLNSNCD-LKVCDFGLARCLASSDQSRENMVGFMTEYVATR 184
L +HS V HRD+KP NLL++ + LK+CDFG A+ L + + Y+ +R
Sbjct: 232 LAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPN--------VSYICSR 283
Query: 185 WYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLED 244
+YRAPE++ +YT+++D+WS GC+LAE+++G+P+FPG QL I++VLG+PT
Sbjct: 284 YYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTR-- 341
Query: 245 FEQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEH 304
EQI+ + P K PW V P AI L S +L + P R+S +EA H
Sbjct: 342 -EQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAH 400
Query: 305 PY 306
+
Sbjct: 401 SF 402
>Hs11995474 [G] KOG0658 Glycogen synthase kinase-3
Length = 483
Score = 157 bits (396), Expect = 3e-38
Identities = 100/302 (33%), Positives = 161/302 (53%), Gaps = 26/302 (8%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTLRELKLLKFFHSHENI 72
Y + ++G G++G V A T VAIKK+ R F R L+ ++ L H NI
Sbjct: 119 YTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKR--FKNRELQIMRKL----DHCNI 172
Query: 73 ISVLDIVRPTSWHKFEAVYL--VQELMETDLQKIINQQNLSED-----HIQYFVYQILRA 125
+ L +S K + +YL V E + + ++ ++ +++ ++YQ+ R+
Sbjct: 173 VR-LRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRS 231
Query: 126 LKSLHSAQVIHRDLKPSNLLLNSNCD-LKVCDFGLARCLASSDQSRENMVGFMTEYVATR 184
L +HS V HRD+KP NLL++ + LK+CDFG A+ L + + Y+ +R
Sbjct: 232 LAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPN--------VSYICSR 283
Query: 185 WYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLED 244
+YRAPE++ +YT+++D+WS GC+LAE+++G+P+FPG QL I++VLG+PT
Sbjct: 284 YYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTR-- 341
Query: 245 FEQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEH 304
EQI+ + P K PW V P AI L S +L + P R+S +EA H
Sbjct: 342 -EQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAH 400
Query: 305 PY 306
+
Sbjct: 401 SF 402
>YMR139w [G] KOG0658 Glycogen synthase kinase-3
Length = 370
Score = 155 bits (391), Expect = 1e-37
Identities = 99/301 (32%), Positives = 167/301 (54%), Gaps = 25/301 (8%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTLRELKLLKFFHSHENI 72
+ ++VG G++G V + + + TN KVAIKK+ R F R L +K+L SH NI
Sbjct: 39 FPTTEVVGHGSFGVVFATVIQETNEKVAIKKVLQDKR--FKNRELEIMKML----SHINI 92
Query: 73 ISVLDIVRPTSWHKFEAVYLVQELMETDLQK----IINQQN-LSEDHIQYFVYQILRALK 127
I + + L+ E M L + ++Q+ +S I+Y+++Q+ ++L
Sbjct: 93 IDLKYFFYERDSQDEIYLNLILEYMPQSLYQRLRHFVHQRTPMSRLEIKYYMFQLFKSLN 152
Query: 128 SLHS-AQVIHRDLKPSNLLLNSNC-DLKVCDFGLARCLASSDQSRENMVGFMTEYVATRW 185
LH A V HRD+KP NLL++ LK+CDFG A+ L ++ + Y+ +R+
Sbjct: 153 YLHHFANVCHRDIKPQNLLVDPETWSLKLCDFGSAKQLKPTEPN--------VSYICSRY 204
Query: 186 YRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDF 245
YRAPE++ YT +DIWS GC++AE+++G+P+FPG+ QL I+++LG+P+
Sbjct: 205 YRAPELIFGATNYTNQIDIWSSGCVMAELLLGQPMFPGESGIDQLVEIIKILGTPSK--- 261
Query: 246 EQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEHP 305
++I S + P K IP + V KE + ++ L+ +L ++P +R +A++ L P
Sbjct: 262 QEICSMNPNYMEHKFPQIKPIPLSRVFKKE-DDQTVEFLADVLKYDPLERFNALQCLCSP 320
Query: 306 Y 306
Y
Sbjct: 321 Y 321
>Hs7705551 [T] KOG0661 MAPK related serine/threonine protein kinase
Length = 632
Score = 155 bits (391), Expect = 1e-37
Identities = 101/308 (32%), Positives = 162/308 (51%), Gaps = 28/308 (9%)
Query: 11 SHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTLRELKLLKFFHSHE 70
+ Y + +G+G YG+V + +AIKK++ S RE+K LK + H
Sbjct: 2 NRYTTIRQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEECMNQREVKSLKKLN-HA 60
Query: 71 NIISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQN--LSEDHIQYFVYQILRALKS 128
N++ + +++R + +Y + E M+ +L ++I ++N E I+ +YQIL+ L
Sbjct: 61 NVVKLKEVIREN-----DHLYFIFEYMKENLYQLIKERNKLFPESAIRNIMYQILQGLAF 115
Query: 129 LHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRA 188
+H HRDLKP NLL +K+ DFGLAR + S T+YV+TRWYRA
Sbjct: 116 IHKLGFFHRDLKPENLLCMGPELVKIADFGLAREIRSKPP--------YTDYVSTRWYRA 167
Query: 189 PEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFE-- 246
PE++L Y++ +D+W+ GCI+AE+ +PLFPG ++ I +VLG+P D+
Sbjct: 168 PEVLLRSTNYSSPIDVWAVGCIMAEVYTLRPLFPGASEIDTIFKICQVLGTPKKTDWPEG 227
Query: 247 -QIKSKRAKEYISQLP--MKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALE 303
Q+ S + +P +K IP + A+ LL ML ++P KR +A +AL
Sbjct: 228 YQLSSAMNFRWPQCVPNNLKTLIP-------NASSEAVQLLRDMLQWDPKKRPTASQALR 280
Query: 304 HPYLATYH 311
+PY H
Sbjct: 281 YPYFQVGH 288
>Hs4758652 [R] KOG0593 Predicted protein kinase KKIAMRE
Length = 358
Score = 154 bits (388), Expect = 3e-37
Identities = 92/308 (29%), Positives = 165/308 (52%), Gaps = 21/308 (6%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTR-TLRELKLLKFFHSHEN 71
Y+ + +GEG+YG V ++ T VAIKK + + LRE+++LK H N
Sbjct: 5 YEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQL-KHPN 63
Query: 72 IISVLDIVRPTSWHKFEAVYLVQELMETDLQKIIN--QQNLSEDHIQYFVYQILRALKSL 129
++++L++ R + ++LV E + + ++ Q+ + E ++ +Q L+A+
Sbjct: 64 LVNLLEVFR-----RKRRLHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVNFC 118
Query: 130 HSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRAP 189
H IHRD+KP N+L+ + +K+CDFG AR L + T+YVATRWYR+P
Sbjct: 119 HKHNCIHRDVKPENILITKHSVIKLCDFGFARLLTGPSD-------YYTDYVATRWYRSP 171
Query: 190 EIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQIK 249
E+++ +Y +D+W+ GC+ AE++ G PL+PGK QL++I + LG + +Q+
Sbjct: 172 ELLVGDTQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGD-LIPRHQQVF 230
Query: 250 SKRAKEYIS--QLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEHPYL 307
S +Y S ++P + + + ++ A+ LL L +P +R++ + L HPY
Sbjct: 231 S--TNQYFSGVKIPDPEDMEPLELKFPNISYPALGLLKGCLHMDPTERLTCEQLLHHPYF 288
Query: 308 ATYHDPDD 315
+ +D
Sbjct: 289 ENIREIED 296
>CE01761 [R] KOG0663 Protein kinase PITSLRE and related kinases
Length = 719
Score = 154 bits (388), Expect = 3e-37
Identities = 102/344 (29%), Positives = 177/344 (50%), Gaps = 27/344 (7%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQ-PFSRSMFVTRTLRELKLLKFFHSHEN 71
Y+ V+ V EG +G V K T+ VA+K+++ + F LRE+ +L +H N
Sbjct: 356 YECVNRVDEGTFGVVYRGKDKRTDEIVALKRLKMEKEKEGFPITALREINMLLKAGNHPN 415
Query: 72 IISVLDIVRPTSWHKFEAVYLVQELMETDLQKIIN-----QQNLSEDHIQYFVYQILRAL 126
I++V +I+ ++ K +Y+ E +E D++ +++ + S + + Q+L +
Sbjct: 416 IVNVKEILLGSNMDK---IYMAMEFVEHDMKSLLDTMSRRNKRFSIGEQKTLLQQLLSGI 472
Query: 127 KSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWY 186
+ +H ++HRDLK SNLL++ LK+ DFGLAR D ++ T V T WY
Sbjct: 473 EHMHKLWILHRDLKTSNLLMSHKGILKIADFGLAR--EYGDPLKK-----FTSIVVTLWY 525
Query: 187 RAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPT----- 241
R+PE++L + Y+T +D+WS GCI+AE I+ KPLFPG+ Q+ I +G+PT
Sbjct: 526 RSPELLLGTRLYSTPVDMWSVGCIMAEFILLKPLFPGRGELEQIKKIFMEMGTPTESIWP 585
Query: 242 -LEDFEQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVE 300
+ + + K+ ++Y K+ + + +N LL+ +LT +P R SA +
Sbjct: 586 GVTELDGWKALTFEKYPYNQLRKRFL-----AGRLLNDTGFKLLNGLLTLDPKNRFSATQ 640
Query: 301 ALEHPYLATYHDPDDEPDYPQLNLEDNFWKIDNEARDKNEEDDI 344
AL+H + P ++P + K A+ K +E+ I
Sbjct: 641 ALDHEWFTEEPYPVPPEEFPTFPAKSEQNKAPPPAKQKQQENRI 684
>7296346 [R] KOG0663 Protein kinase PITSLRE and related kinases
Length = 952
Score = 154 bits (388), Expect = 3e-37
Identities = 106/318 (33%), Positives = 167/318 (52%), Gaps = 21/318 (6%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQ-PFSRSMFVTRTLRELKLLKFFHSHEN 71
+Q ++ + EG YG V A K TN VA+K+++ + F +LRE+ L H N
Sbjct: 558 FQCLNRIEEGTYGVVYRAKDKRTNEIVALKRLKMEKEKEGFPITSLREINTL-LKGQHPN 616
Query: 72 IISVLDIVRPTSWHKFEAVYLVQELMETDLQKIIN-----QQNLSEDHIQYFVYQILRAL 126
I++V +IV ++ K +++V + +E DL+ ++ +Q+ ++ Q+LRA+
Sbjct: 617 IVTVREIVVGSNMDK---IFIVMDYVEHDLKSLMETMKNRKQSFFPGEVKCLTQQLLRAV 673
Query: 127 KSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWY 186
LH ++HRDLK SNLLL+ LKV DFGLAR S + T V T WY
Sbjct: 674 AHLHDNWILHRDLKTSNLLLSHKGILKVGDFGLAREYGSPIKK-------YTSLVVTLWY 726
Query: 187 RAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFE 246
RAPE++L Y+T +D+WS GCI AE + PLFPGK +L I + LG+P + +
Sbjct: 727 RAPELLLCSPVYSTPIDVWSVGCIFAEFLQMLPLFPGKSEIDELNRIFKELGTPNEKIWP 786
Query: 247 QIKSKRA-KEYISQLPMKKGIPWANV---LNKEVNPLAIDLLSKMLTFNPDKRISAVEAL 302
A K +SQ P + + ++ + + + LL +LT++P +R+SA AL
Sbjct: 787 GYTELPAVKNMLSQNSQFTEYPVSQLRKHFQEKTSEMGLSLLQGLLTYDPKQRLSADAAL 846
Query: 303 EHPYLATYHDPDDEPDYP 320
+H + P D +P
Sbjct: 847 KHGFFKELPLPIDPSMFP 864
>Hs4502735 [R] KOG0594 Protein kinase PCTAIRE and related kinases
Length = 303
Score = 153 bits (386), Expect = 4e-37
Identities = 109/317 (34%), Positives = 164/317 (51%), Gaps = 26/317 (8%)
Query: 11 SHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSM----FVTRTLRELKLLKFF 66
S Y+ V +G GAYGTV A + VA+K ++ + T+RE+ LL+
Sbjct: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63
Query: 67 HS--HENIISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQ---NLSEDHIQYFVYQ 121
+ H N++ ++D+ + + V LV E ++ DL+ +++ L + I+ + Q
Sbjct: 64 EAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQ 123
Query: 122 ILRALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYV 181
LR L LH+ ++HRDLKP N+L+ S +K+ DFGLAR + +T V
Sbjct: 124 FLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMA--------LTPVV 175
Query: 182 ATRWYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPT 241
T WYRAPE++L Y T +D+WS GCI AEM KPLF G QL I +++G P
Sbjct: 176 VTLWYRAPEVLLQ-STYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPP 234
Query: 242 LEDFEQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEA 301
+D+ + S + P + P +V+ E+ LL +MLTFNP KRISA A
Sbjct: 235 EDDWPRDVSLPRGAF----PPRGPRPVQSVV-PEMEESGAQLLLEMLTFNPHKRISAFRA 289
Query: 302 LEHPYLATYHDPDDEPD 318
L+H YL H + P+
Sbjct: 290 LQHSYL---HKDEGNPE 303
>At1g33770 [D] KOG0600 Cdc2-related protein kinase
Length = 614
Score = 152 bits (385), Expect = 6e-37
Identities = 112/335 (33%), Positives = 175/335 (51%), Gaps = 20/335 (5%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTL-RELKLLKFFHSHEN 71
++ +D +G+G Y V A T VA+KK++ + R + RE+ +L+ H N
Sbjct: 141 FEKLDKIGQGTYSIVYKARDLETGKIVAMKKVRFANMDPESVRFMAREINILRKL-DHPN 199
Query: 72 IISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQNL--SEDHIQYFVYQILRALKSL 129
++ + +V +++LV E ME DL + + + +E I+ F+ Q+L L+
Sbjct: 200 VMKLQCLVTSKL---SGSLHLVFEYMEHDLSGLALRPGVKFTEPQIKCFMKQLLCGLEHC 256
Query: 130 HSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRAP 189
HS ++HRD+K SNLL+N++ LK+ DFGLA DQ + +T V T WYRAP
Sbjct: 257 HSRGILHRDIKGSNLLVNNDGVLKIGDFGLAS-FYKPDQDQP-----LTSRVVTLWYRAP 310
Query: 190 EIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQIK 249
E++L EY A+D+WS GCILAE+ + KP+ PG+ Q+ I ++ GSP+ E + K
Sbjct: 311 ELLLGSTEYGPAIDLWSVGCILAELFVCKPIMPGRTEVEQMHKIFKLCGSPSEEFWNTTK 370
Query: 250 SKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEHPYLAT 309
+A Y Q P K+ + K ++ ++DLL K+L+ P+KR SA L + T
Sbjct: 371 FPQATSYKPQHPYKRVL---LETFKNLSSSSLDLLDKLLSVEPEKRCSASSTLLSEFFTT 427
Query: 310 YHDP---DDEPDYPQLNLEDNFWKIDNEARDKNEE 341
P P YP D + D EA+ K E
Sbjct: 428 EPLPCHISSLPKYPPSKELDAKVR-DEEAKRKKAE 461
>SPBPI064 [G] KOG0658 Glycogen synthase kinase-3
Length = 350
Score = 152 bits (384), Expect = 7e-37
Identities = 93/267 (34%), Positives = 144/267 (53%), Gaps = 19/267 (7%)
Query: 55 RTLRELKLLKFFHSHENIISVLDIVRPTSWHKFEA--VYLVQELMETDLQKII----NQQ 108
R REL++++ SH NII ++ + K E L++ + ET + ++
Sbjct: 31 RVNRELQIMRAI-SHPNIIKLIAFFHTHNPSKDETHLCLLLEYMPETVFDDMRWYTRRRK 89
Query: 109 NLSEDHIQYFVYQILRALKSLHSAQVIHRDLKPSNLLLNSNCD-LKVCDFGLARCLASSD 167
++ I+ + +Q+ RAL LHS V HRD+KP NLL++ LK+CDFG A+ L S+
Sbjct: 90 SIPNLSIKLYAFQLFRALAYLHSTGVCHRDIKPQNLLVDYKTGILKLCDFGSAKVLVPSE 149
Query: 168 QSRENMVGFMTEYVATRWYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYH 227
+ Y+ +R+YRAPE++ YTT +D+WS C++AE+ +G+PLFPG
Sbjct: 150 PN--------VSYICSRYYRAPELVFGATHYTTKIDVWSAACVIAELFIGRPLFPGDSSV 201
Query: 228 HQLWIILEVLGSPTLEDFEQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKM 287
QL I+ VLG+P+ + +I LP + +V+ A+DLL KM
Sbjct: 202 EQLVEIIRVLGTPS---YHEISVMNPNYVNHSLPNVRPHTLESVMPHNCTKNAMDLLHKM 258
Query: 288 LTFNPDKRISAVEALEHPYLATYHDPD 314
LT+ P KRISA+E L HP+ DP+
Sbjct: 259 LTYVPSKRISAIEVLTHPFFDELRDPN 285
>At5g63610 [K] KOG0666 Cyclin C-dependent kinase CDK8
Length = 470
Score = 152 bits (384), Expect = 7e-37
Identities = 113/319 (35%), Positives = 171/319 (53%), Gaps = 36/319 (11%)
Query: 13 YQLVDLVGEGAYGTVCSAIHK-PTNTKVAIKKIQPFSRSMFVTRT-LRELKLLKFFHSHE 70
Y LV +GEG YG V A K P +AIKK + V+ T +RE+ LL+ SHE
Sbjct: 25 YNLVGKIGEGTYGLVFLARTKTPPKRPIAIKKFKQSKDGDGVSPTAIREIMLLREI-SHE 83
Query: 71 NIISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQNLSEDH------IQYFVYQILR 124
N++ ++++ + ++YL + E DL +II H ++ ++Q+L
Sbjct: 84 NVVKLVNVHINFA---DMSLYLAFDYAEYDLYEIIRHHRDKVGHSLNTYTVKSLLWQLLN 140
Query: 125 ALKSLHSAQVIHRDLKPSNLLLNSNCD----LKVCDFGLARCL-ASSDQSRENMVGFMTE 179
L LHS +IHRDLKPSN+L+ + + +K+ DFGLAR A +N V
Sbjct: 141 GLNYLHSNWIIHRDLKPSNILVMGDAEEHGIVKIADFGLARIYQAPLKPLSDNGV----- 195
Query: 180 YVATRWYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYH--------HQLW 231
V T WYRAPE++L + YT+A+D+W+ GCI AE++ KPLF G + QL
Sbjct: 196 -VVTIWYRAPELLLGSKHYTSAVDMWAVGCIFAELLTLKPLFQGAEAKSSQNPFQLDQLD 254
Query: 232 IILEVLGSPTLEDFEQIKS----KRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKM 287
I ++LG PT++ + + + + ++I Q + NV++ A DLLSKM
Sbjct: 255 KIFKILGHPTMDKWPTLVNLPHWQNDVQHI-QAHKYDSVGLHNVVHLNQKSPAYDLLSKM 313
Query: 288 LTFNPDKRISAVEALEHPY 306
L ++P KRI+A +ALEH Y
Sbjct: 314 LEYDPLKRITASQALEHEY 332
>7297009 [R] KOG0593 Predicted protein kinase KKIAMRE
Length = 392
Score = 152 bits (384), Expect = 7e-37
Identities = 100/310 (32%), Positives = 159/310 (51%), Gaps = 33/310 (10%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTR-TLRELKLLKFFHSHEN 71
Y+ + +GEG+YG V + T VA+K+ + + LRE++LLK H N
Sbjct: 4 YEKLSRLGEGSYGVVYKCRDRETGALVAVKRFVESEDDPAIRKIALREIRLLKNL-KHPN 62
Query: 72 IISVLDIVRPTSWHKFEAVYLVQELME-TDLQKIINQQNLSEDHI-QYFVYQILRALKSL 129
++S+L++ R + ++LV E E T L ++ +H+ + YQ L +
Sbjct: 63 LVSLLEVFR-----RKRRLHLVFEFCELTVLHELERHPQGCPEHLTKQICYQTLLGVAYC 117
Query: 130 HSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRAP 189
H +HRD+KP N+LL + +K+CDFG AR L+ + T+YVATRWYRAP
Sbjct: 118 HKQGCLHRDIKPENILLTAQGQVKLCDFGFARMLSPGEN--------YTDYVATRWYRAP 169
Query: 190 EIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQIK 249
E+++ +Y T +D+W+ GC+ AE++ G+ L+PG+ QL++I + LG L QI
Sbjct: 170 ELLVGDTQYGTPVDVWAIGCLFAELVRGEALWPGRSDVDQLYLIRKTLGD-LLPRHIQIF 228
Query: 250 SKRAKEYISQL---------PMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVE 300
+ EY + P++ +P + NPL ID L K L +P KR S +
Sbjct: 229 GQ--NEYFKGITLPVPPTLEPLEDKMP----AKSQQNPLTIDFLKKCLDKDPTKRWSCEK 282
Query: 301 ALEHPYLATY 310
+H Y Y
Sbjct: 283 LTKHSYFDDY 292
>7291442 [D] KOG0669 Cyclin T-dependent kinase CDK9
Length = 404
Score = 152 bits (383), Expect = 1e-36
Identities = 105/327 (32%), Positives = 167/327 (50%), Gaps = 28/327 (8%)
Query: 7 YDIP-----SHYQLVDLVGEGAYGTVCSAIHKPTNTK-VAIKKI-QPFSRSMFVTRTLRE 59
YD P + Y+ V +G+G +G V A K N K VA+KK+ + F LRE
Sbjct: 39 YDFPYCDESNKYEKVAKIGQGTFGEVFKAREKKGNKKFVAMKKVLMDNEKEGFPITALRE 98
Query: 60 LKLLKFFHSHENIISVLDIVRP--TSWHKFEAV-YLVQELMETDLQKIINQQNL--SEDH 114
+++L+ HEN++++++I R T+ + + + YLV + E DL +++ N+ S
Sbjct: 99 IRILQLL-KHENVVNLIEICRTKATATNGYRSTFYLVFDFCEHDLAGLLSNMNVKFSLGE 157
Query: 115 IQYFVYQILRALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMV 174
I+ + Q+L L +HS +++HRD+K +N+L+ + LK+ DFGLAR + +N
Sbjct: 158 IKKVMQQLLNGLYYIHSNKILHRDMKAANVLITKHGILKLADFGLARAFSIPKNESKNRY 217
Query: 175 GFMTEYVATRWYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIIL 234
T V T WYR PE++L + Y +D+W GCI+AEM P+ G QL I
Sbjct: 218 ---TNRVVTLWYRPPELLLGDRNYGPPVDMWGAGCIMAEMWTRSPIMQGNTEQQQLTFIS 274
Query: 235 EVLGS------PTLEDFEQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKML 288
++ GS P +E+ E KS + + ++ P+ + DLL K+L
Sbjct: 275 QLCGSFTPDVWPGVEELELYKSIELPKNQKRRVKERLRPYVK------DQTGCDLLDKLL 328
Query: 289 TFNPDKRISAVEALEHPYLATYHDPDD 315
T +P KRI A AL H + T P D
Sbjct: 329 TLDPKKRIDADTALNHDFFWTDPMPSD 355
>At1g09600 [D] KOG0600 Cdc2-related protein kinase
Length = 714
Score = 151 bits (382), Expect = 1e-36
Identities = 107/334 (32%), Positives = 170/334 (50%), Gaps = 20/334 (5%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTL-RELKLLKFFHSHEN 71
++ ++ +G+G Y +V A TN VA+KK++ + R + RE+ +L+ H N
Sbjct: 163 FEKLEKIGQGTYSSVYKARDLETNQLVALKKVRFANMDPDSVRFMAREIIILRRL-DHPN 221
Query: 72 IISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQ--NLSEDHIQYFVYQILRALKSL 129
++ + ++ ++YL+ E ME DL + + N SE I+ ++ Q+L L+
Sbjct: 222 VMKLEGLITS---RVSGSMYLIFEYMEHDLAGLASTPGINFSEAQIKCYMKQLLHGLEHC 278
Query: 130 HSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRAP 189
HS V+HRD+K SNLLL+ N +LK+ DFGLA + +T V T WYR P
Sbjct: 279 HSRGVLHRDIKGSNLLLDHNNNLKIGDFGLANFYQGHQKQP------LTSRVVTLWYRPP 332
Query: 190 EIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQIK 249
E++L +Y +D+WS GCILAE+ GKP+ PG+ QL I ++ GSP+ E ++ K
Sbjct: 333 ELLLGSTDYGVTVDLWSTGCILAELFTGKPIMPGRTEVEQLHKIFKLCGSPSEEYWKISK 392
Query: 250 SKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEHPYLAT 309
A + Q P K+ + K + A+ L+ +L PD R + ALE + T
Sbjct: 393 LPHATIFKPQQPYKRCVA---ETFKSLPSSALALVEVLLAVEPDARGTTASALESEFFTT 449
Query: 310 ---YHDPDDEPDYPQLNLEDNFWKIDNEARDKNE 340
DP P Y Q E + + EA+ K +
Sbjct: 450 SPLASDPSSLPKY-QPRKEIDVKAQEEEAKRKKD 482
>Hs21361340 [G] KOG0658 Glycogen synthase kinase-3
Length = 433
Score = 151 bits (381), Expect = 2e-36
Identities = 102/323 (31%), Positives = 165/323 (50%), Gaps = 39/323 (12%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTLRELKLLKFFHSHENI 72
Y ++G G++G V A + VAIKK+ R F R L+ ++ L H NI
Sbjct: 56 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKR--FKNRELQIMRKL----DHCNI 109
Query: 73 ISVLDIVRPTSWHKFEAVYL--VQELMETDLQKIIN-----QQNLSEDHIQYFVYQILRA 125
+ L +S K + VYL V + + + ++ +Q L +++ ++YQ+ R+
Sbjct: 110 VR-LRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRS 168
Query: 126 LKSLHSAQVIHRDLKPSNLLLNSNCD-LKVCDFGLARCLASSDQSRENMVGFMTEYVATR 184
L +HS + HRD+KP NLLL+ + LK+CDFG A+ L + + Y+ +R
Sbjct: 169 LAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPN--------VSYICSR 220
Query: 185 WYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLED 244
+YRAPE++ +YT+++D+WS GC+LAE+++G+P+FPG QL I++VLG+PT
Sbjct: 221 YYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTR-- 278
Query: 245 FEQIKSKRAKEYISQLPMKKGIPW-------------ANVLNKEVNPLAIDLLSKMLTFN 291
EQI+ + P K PW V P AI L S++L +
Sbjct: 279 -EQIREMNPNYTEFKFPQIKAHPWTKDSSGTGHFTSGVRVFRPRTPPEAIALCSRLLEYT 337
Query: 292 PDKRISAVEALEHPYLATYHDPD 314
P R++ +EA H + DP+
Sbjct: 338 PTARLTPLEACAHSFFDELRDPN 360
>Hs4503095 [TDK] KOG0668 Casein kinase II alpha subunit
Length = 391
Score = 150 bits (380), Expect = 2e-36
Identities = 97/304 (31%), Positives = 166/304 (53%), Gaps = 23/304 (7%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTLRELKLLKFFHSHENI 72
YQLV +G G Y V AI+ N KV +K ++P + + RE+K+L+ NI
Sbjct: 39 YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKK----KIKREIKILENLRGGPNI 94
Query: 73 ISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQNLSEDHIQYFVYQILRALKSLHSA 132
I++ DIV+ V+ + + TD +++ Q L++ I++++Y+IL+AL HS
Sbjct: 95 ITLADIVKDPVSRTPALVF--EHVNNTDFKQLY--QTLTDYDIRFYMYEILKALDYCHSM 150
Query: 133 QVIHRDLKPSNLLLN-SNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRAPEI 191
++HRD+KP N++++ + L++ D+GLA + VA+R+++ PE+
Sbjct: 151 GIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVR--------VASRYFKGPEL 202
Query: 192 MLSFQEYTTAMDIWSCGCILAEMIMGK-PLFPGKDYHHQLWIILEVLGSPTLEDF-EQIK 249
++ +Q Y ++D+WS GC+LA MI K P F G D + QL I +VLG+ L D+ ++
Sbjct: 203 LVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYN 262
Query: 250 SKRAKEYISQLPMKKGIPWANVLNKE----VNPLAIDLLSKMLTFNPDKRISAVEALEHP 305
+ + L W ++ E V+P A+D L K+L ++ R++A EA+EHP
Sbjct: 263 IELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHP 322
Query: 306 YLAT 309
Y T
Sbjct: 323 YFYT 326
>At4g22940 [D] KOG0600 Cdc2-related protein kinase
Length = 458
Score = 150 bits (380), Expect = 2e-36
Identities = 107/344 (31%), Positives = 176/344 (51%), Gaps = 29/344 (8%)
Query: 11 SHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQ-PFSRSMFVTRTLRELKLLKFFHSH 69
SH++ + +G G + V A N VA+K+I+ + S + RE+ +L+ H
Sbjct: 101 SHFEKQEQIGGGTFSKVFKARDLLRNKTVALKRIRFDINNSESIKCIAREIIILRKL-DH 159
Query: 70 ENIISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQNL--SEDHIQYFVYQILRALK 127
N+I + ++ H +YL+ E ME DL + + + SE ++ ++ Q+LR L
Sbjct: 160 PNVIKLEGLMLVD--HDSSTLYLIFEYMEHDLLGLSSLLGVHFSEPQVKCYMRQLLRGLD 217
Query: 128 SLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYR 187
H+ V+HRD+K SNLL+N + LK+ DFGLA N V +T +VAT WYR
Sbjct: 218 HCHTNHVLHRDMKSSNLLINGDGVLKIADFGLATFF-----DPHNSVP-LTTHVATLWYR 271
Query: 188 APEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQ 247
PE++L Y +D+WS GC++ E+ GKP+ PGK+ QL I ++ GSP+ + + +
Sbjct: 272 PPELLLGASHYGIGVDLWSTGCVIGELYAGKPILPGKNETDQLHKIFKLCGSPSDDYWTK 331
Query: 248 IKSKRAKEYISQLPMKKGIPWANVLN---KEVNPLAIDLLSKMLTFNPDKRISAVEALEH 304
+K + + P++ P+ + + K+ I LL +L+ +PD R +A AL+
Sbjct: 332 LKLQLS------TPLRPIYPYGSHIAETFKQFPASVISLLETLLSIDPDFRGTAASALKS 385
Query: 305 PYLATYH---DPDDEPDYP-----QLNLEDNFWKIDNEARDKNE 340
Y T DP P YP + + DN K ++ R +E
Sbjct: 386 KYFKTEPLACDPSCLPKYPSSKEINIKMRDNTRKQASQIRRTDE 429
>At5g44290 [D] KOG0600 Cdc2-related protein kinase
Length = 644
Score = 150 bits (379), Expect = 3e-36
Identities = 102/316 (32%), Positives = 165/316 (51%), Gaps = 19/316 (6%)
Query: 11 SHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQ-PFSRSMFVTRTLRELKLLKFFHSH 69
S ++ ++ +G+G Y +V A N VA+K+++ S V RE+ +++ H
Sbjct: 135 STFEKLEKIGQGTYSSVYKARDLTNNKIVALKRVRFDLSDLESVKFMAREIIVMRRL-DH 193
Query: 70 ENIISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQNL--SEDHIQYFVYQILRALK 127
N++ + ++ + ++YLV E M+ DL + + + SE ++ ++ Q+L L
Sbjct: 194 PNVLKLEGLITASV---SSSLYLVFEYMDHDLVGLASIPGIKFSEPQVKCYMQQLLSGLH 250
Query: 128 SLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYR 187
HS V+HRD+K SNLL++SN LK+ DFGLA +N V +T V T WYR
Sbjct: 251 HCHSRGVLHRDIKGSNLLIDSNGVLKIADFGLATFF-----DPQNCVP-LTSRVVTLWYR 304
Query: 188 APEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQ 247
PE++L Y +D+WS GCIL E+ GKP+ GK QL I ++ GSPT + + +
Sbjct: 305 PPELLLGACHYGVGVDLWSTGCILGELYSGKPILAGKTEVEQLHKIFKLCGSPTEDYWRK 364
Query: 248 IKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEHPYL 307
+K + + LP + + + K++ + LL +L+ +PD+R SA ALE Y
Sbjct: 365 LKLPPSAAFRPALPYGRRVA---EMFKDLPTNVLSLLEALLSIDPDRRGSAARALESEYF 421
Query: 308 ATYH---DPDDEPDYP 320
T DP P YP
Sbjct: 422 RTEPFACDPSSLPKYP 437
>At1g53050 [D] KOG0600 Cdc2-related protein kinase
Length = 694
Score = 150 bits (378), Expect = 4e-36
Identities = 106/314 (33%), Positives = 164/314 (51%), Gaps = 19/314 (6%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTL-RELKLLKFFHSHEN 71
++ +D +G+G Y V A VA+KK++ + R + RE+++L+ H N
Sbjct: 134 FEKLDKIGQGTYSNVYRARDLDQKKIVALKKVRFDNLEPESVRFMAREIQILRRL-DHPN 192
Query: 72 IISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQNL--SEDHIQYFVYQILRALKSL 129
II + +V ++YLV E ME DL + + + SE ++ ++ Q+L L
Sbjct: 193 IIKLEGLVTS---RMSCSLYLVFEYMEHDLAGLASHPAIKFSESQVKCYLQQLLHGLDHC 249
Query: 130 HSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRAP 189
HS V+HRD+K SNLL++++ LK+ DFGLA S R+ +T V T WYR P
Sbjct: 250 HSRGVLHRDIKGSNLLIDNSGVLKIADFGLA----SFFDPRQTQP--LTSRVVTLWYRPP 303
Query: 190 EIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQIK 249
E++L Y A+D+WS GCILAE+ GKP+ PG+ QL I ++ GSPT + + + +
Sbjct: 304 ELLLGATRYGAAVDLWSAGCILAELYAGKPIMPGRTEVEQLHKIFKLCGSPTEDYWVKSR 363
Query: 250 SKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEHPYLAT 309
A + P K+ + KE A+ LL +L+ NPD R +A AL+ + +T
Sbjct: 364 LPHATIFKPTQPYKRLV---GETFKEFPQPALALLETLLSVNPDDRGTATAALKSEFFST 420
Query: 310 YH---DPDDEPDYP 320
DP P YP
Sbjct: 421 RPLPCDPSSLPKYP 434
>At1g03740 [D] KOG0600 Cdc2-related protein kinase
Length = 542
Score = 149 bits (377), Expect = 5e-36
Identities = 103/333 (30%), Positives = 173/333 (51%), Gaps = 27/333 (8%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTL-RELKLLKFFHSHEN 71
++ ++ +G+G Y +V A N VA+KK++ M + + RE+ +++ H N
Sbjct: 213 FEKLEKIGQGTYSSVYRARDLLHNKIVALKKVRFDLNDMESVKFMAREIIVMRRL-DHPN 271
Query: 72 IISVLDIVR-PTSWHKFEAVYLVQELMETDLQKIINQQNL--SEDHIQYFVYQILRALKS 128
++ + ++ P S ++YLV E M+ DL + + + +E ++ ++ Q+L L+
Sbjct: 272 VLKLEGLITAPVS----SSLYLVFEYMDHDLLGLSSLPGVKFTEPQVKCYMRQLLSGLEH 327
Query: 129 LHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRA 188
HS V+HRD+K SNLL++S LK+ DFGLA + +T +V T WYR
Sbjct: 328 CHSRGVLHRDIKGSNLLIDSKGVLKIADFGLATFFDPAKSVS------LTSHVVTLWYRP 381
Query: 189 PEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQI 248
PE++L Y +D+WS GCIL E+ GKP+ PGK QL I ++ GSPT + +
Sbjct: 382 PELLLGASHYGVGVDLWSTGCILGELYAGKPILPGKTEVEQLHKIFKLCGSPTENYWRKQ 441
Query: 249 KSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEHPYLA 308
K + + + +P ++ + + + K+ + LL +L+ +PD R SA ALE Y
Sbjct: 442 KLPSSAGFKTAIPYRRKV---SEMFKDFPASVLSLLETLLSIDPDHRSSADRALESEYFK 498
Query: 309 TYH---DPDDEPDYPQLNLEDNFWKIDNEARDK 338
T DP + P YP +ID + RD+
Sbjct: 499 TKPFACDPSNLPKYPPSK------EIDAKMRDE 525
>At5g50860 [D] KOG0600 Cdc2-related protein kinase
Length = 580
Score = 149 bits (375), Expect = 8e-36
Identities = 102/317 (32%), Positives = 161/317 (50%), Gaps = 25/317 (7%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQ----PFSRSMFVTRTLRELKLLKFFHS 68
Y+ ++ +G+G Y V A + VA+KK++ F+ R + L+ L +
Sbjct: 114 YEKLEKIGQGTYSNVYKAKDLLSGKIVALKKVRFDNLEAESVKFMAREILVLRRL----N 169
Query: 69 HENIISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQNLSED--HIQYFVYQILRAL 126
H N+I + +V ++YLV E ME DL + Q L D ++ F+ Q+L L
Sbjct: 170 HPNVIKLQGLVTS---RVSCSLYLVFEYMEHDLSGLAATQGLKFDLPQVKCFMKQLLSGL 226
Query: 127 KSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWY 186
+ HS V+HRD+K SNLL++++ LK+ DFGLA + MT V T WY
Sbjct: 227 EHCHSRGVLHRDIKGSNLLIDNDGILKIADFGLATFYDPKQKQT------MTSRVVTLWY 280
Query: 187 RAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFE 246
R PE++L Y T +D+WS GCI+AE++ GKP+ PG+ QL I ++ GSP+ ++
Sbjct: 281 RPPELLLGATSYGTGVDLWSAGCIMAELLAGKPVMPGRTEVEQLHKIFKLCGSPSDSYWK 340
Query: 247 QIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEHPY 306
+ + A + Q P K+ + A N P ++ L+ +LT +P R ++ AL +
Sbjct: 341 KYRLPNATLFKPQHPYKRCV--AEAFN-GFTPSSVHLVETLLTIDPADRGTSTSALNSEF 397
Query: 307 LATYH---DPDDEPDYP 320
T DP P YP
Sbjct: 398 FTTEPLPCDPSSLPKYP 414
>Hs4502731 [R] KOG0663 Protein kinase PITSLRE and related kinases
Length = 360
Score = 148 bits (374), Expect = 1e-35
Identities = 105/317 (33%), Positives = 168/317 (52%), Gaps = 25/317 (7%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQ-PFSRSMFVTRTLRELKLLKFFHSHEN 71
++ ++ +GEG YG V A T+ VA+KK++ + +LRE+ LL H N
Sbjct: 39 FEKLNRIGEGTYGIVYRARDTQTDEIVALKKVRMDKEKDGIPISSLREITLLLRLR-HPN 97
Query: 72 IISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQN--LSEDHIQYFVYQILRALKSL 129
I+ + ++V + E+++LV E DL ++ SE ++ V Q+LR L+ L
Sbjct: 98 IVELKEVV---VGNHLESIFLVMGYCEQDLASLLENMPTPFSEAQVKCIVLQVLRGLQYL 154
Query: 130 HSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRAP 189
H +IHRDLK SNLL+ +K DFGLAR V MT V T WYRAP
Sbjct: 155 HRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVP-------VKPMTPKVVTLWYRAP 207
Query: 190 EIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQIK 249
E++L TT++D+W+ GCILAE++ +PL PG HQ+ +I+++LG+P+ E I
Sbjct: 208 ELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLIVQLLGTPS----ENIW 263
Query: 250 SKRAK-EYISQLPMKKGIPWANVLNK--EVNPLAIDLLSKMLTFNPDKRISAVEALEHPY 306
+K + Q ++K P+ N+ +K ++ + LL + ++P KR +A + LE Y
Sbjct: 264 PGFSKLPLVGQYSLRKQ-PYNNLKHKFPWLSEAGLRLLHFLFMYDPKKRATAGDCLESSY 322
Query: 307 LATYH---DPDDEPDYP 320
+P+ P +P
Sbjct: 323 FKEKPLPCEPELMPTFP 339
>At4g19110 [T] KOG0661 MAPK related serine/threonine protein kinase
Length = 256
Score = 148 bits (374), Expect = 1e-35
Identities = 86/257 (33%), Positives = 150/257 (57%), Gaps = 21/257 (8%)
Query: 57 LRELKLLKFFHSHENIISVLDIVRPTSWHKFEAVYLVQELMETDLQKIIN--QQNLSEDH 114
LRE+K L+ + H NI+ + +++R + +Y V E ME +L +++ Q+ +E
Sbjct: 14 LREVKSLRRMN-HPNIVKLKEVIREN-----DILYFVFEYMECNLYQLMKDRQKLFAEAD 67
Query: 115 IQYFVYQILRALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMV 174
I+ + +Q+ + L +H HRDLKP NLL++ + +K+ DFGLAR + SS
Sbjct: 68 IKNWCFQVFQGLSYMHQRGYFHRDLKPENLLVSKDI-IKIADFGLAREVNSSPP------ 120
Query: 175 GFMTEYVATRWYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIIL 234
TEYV+TRWYRAPE++L YT+ +D+W+ G I+AE++ +P+FPG +++ I
Sbjct: 121 --FTEYVSTRWYRAPEVLLQSYVYTSKVDMWAMGAIMAELLSLRPIFPGASEADEIYKIC 178
Query: 235 EVLGSPTLEDF-EQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPD 293
V+G+PT E + E + Y Q P G+P ++++ + AI+L+ ++ +++P
Sbjct: 179 SVIGTPTEETWLEGLNLANTINY--QFPQLPGVPLSSLM-PSASEDAINLIERLCSWDPS 235
Query: 294 KRISAVEALEHPYLATY 310
R +A E L+HP+ +
Sbjct: 236 SRPTAAEVLQHPFFQVH 252
>Hs16950647 [R] KOG0663 Protein kinase PITSLRE and related kinases
Length = 314
Score = 148 bits (373), Expect = 1e-35
Identities = 102/300 (34%), Positives = 162/300 (54%), Gaps = 22/300 (7%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQ-PFSRSMFVTRTLRELKLLKFFHSHEN 71
++ ++ +GEG YG V A T+ VA+KK++ + +LRE+ LL H N
Sbjct: 10 FEKLNRIGEGTYGIVYRARDTQTDEIVALKKVRMDKEKDGIPISSLREITLLLRLR-HPN 68
Query: 72 IISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQN--LSEDHIQYFVYQILRALKSL 129
I+ + ++V + E+++LV E DL ++ SE ++ V Q+LR L+ L
Sbjct: 69 IVELKEVV---VGNHLESIFLVMGYCEQDLASLLENMPTPFSEAQVKCIVLQVLRGLQYL 125
Query: 130 HSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRAP 189
H +IHRDLK SNLL+ +K DFGLAR V MT V T WYRAP
Sbjct: 126 HRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVP-------VKPMTPKVVTLWYRAP 178
Query: 190 EIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQIK 249
E++L TT++D+W+ GCILAE++ +PL PG HQ+ +I+++LG+P+ E I
Sbjct: 179 ELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLIVQLLGTPS----ENIW 234
Query: 250 SKRAK-EYISQLPMKKGIPWANVLNK--EVNPLAIDLLSKMLTFNPDKRISAVEALEHPY 306
+K + Q ++K P+ N+ +K ++ + LL + ++P KR +A + LE Y
Sbjct: 235 PGFSKLPLVGQYSLRKQ-PYNNLKHKFPWLSEAGLRLLHFLFMYDPKKRATAGDCLESSY 293
>At3g05050 [D] KOG0600 Cdc2-related protein kinase
Length = 593
Score = 147 bits (372), Expect = 2e-35
Identities = 97/332 (29%), Positives = 169/332 (50%), Gaps = 22/332 (6%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQ-PFSRSMFVTRTLRELKLLKFFHSHEN 71
++ +D +G G Y V A T VA+KK++ + + RE+ +L+ H N
Sbjct: 138 FEKIDKIGSGTYSNVYKAKDSLTGNIVALKKVRCDVNERESLKFMAREILILRRL-DHPN 196
Query: 72 IISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQNL--SEDHIQYFVYQILRALKSL 129
+I + +V ++YLV M+ DL + + +E ++ ++ Q+L L+
Sbjct: 197 VIKLEGLVTS---RMSSSLYLVFRYMDHDLAGLAASPEIKFTEQQVKCYMKQLLSGLEHC 253
Query: 130 HSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRAP 189
H+ V+HRD+K SNLL++ L++ DFGLA +S + MT V T WYR+P
Sbjct: 254 HNRGVLHRDIKGSNLLIDDGGVLRIGDFGLATFFDASKRQE------MTNRVVTLWYRSP 307
Query: 190 EIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQIK 249
E++ EY+ +D+WS GCILAE++ G+ + PG++ QL I ++ GSP+ E +++I+
Sbjct: 308 ELLHGVVEYSVGVDLWSAGCILAELLAGRAIMPGRNEVEQLHRIYKLCGSPSEEYWKKIR 367
Query: 250 SKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEHPYLAT 309
++ P+ + + K+ +P A+ LL +L +P +R +A + L + T
Sbjct: 368 LPSTHKHAHHKPLPQYKRRIREVYKDFSPEALSLLDTLLALDPAERQTATDVLMSDFFTT 427
Query: 310 YH---DPDDEPDYPQLNLEDNFWKIDNEARDK 338
P D P YP +ID + RD+
Sbjct: 428 EPLACQPSDLPKYPPSK------EIDAKRRDE 453
>At1g71530 [D] KOG0600 Cdc2-related protein kinase
Length = 655
Score = 147 bits (371), Expect = 2e-35
Identities = 101/317 (31%), Positives = 161/317 (49%), Gaps = 25/317 (7%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTL-RELKLLKFFHSHEN 71
++ +D +G+G Y +V A T VA+KK++ + R + RE+ +L+ H N
Sbjct: 147 FEKLDKIGQGTYSSVYKARDLETGKIVAMKKVRFVNMDPESVRFMAREILILRKL-DHPN 205
Query: 72 IISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQNL--SEDHIQYFVYQILRALKSL 129
++ + +V ++YLV E ME DL + + SE I+ ++ Q+ R L+
Sbjct: 206 VMKLEGLVTS---RLSGSLYLVFEYMEHDLAGLAATPGIKFSEPQIKCYMQQLFRGLEHC 262
Query: 130 HSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRAP 189
H ++HRD+K SNLL+N+ LK+ DFGLA + +T V T WYRAP
Sbjct: 263 HRRGILHRDIKGSNLLINNEGVLKIGDFGLANFYRGDGDLQ------LTSRVVTLWYRAP 316
Query: 190 EIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQIK 249
E++L EY A+D+WS GCIL E+ GKP+ PG+ Q+ I ++ GSP+ + + +
Sbjct: 317 ELLLGATEYGPAIDLWSAGCILTELFAGKPIMPGRTEVEQMHKIFKLCGSPSEDYWRRAT 376
Query: 250 SKRAKEYISQLPMKKGIPWANVLNKEVNPL---AIDLLSKMLTFNPDKRISAVEALEHPY 306
A + K P+ VL + N A+ L++K+L P+KR SA L +
Sbjct: 377 LPLATSF------KPSHPYKPVLAETFNHFPSSALMLINKLLAIEPEKRGSAASTLRSEF 430
Query: 307 LATY---HDPDDEPDYP 320
T +P + P YP
Sbjct: 431 FTTEPLPANPSNLPRYP 447
>CE20258 [R] KOG0593 Predicted protein kinase KKIAMRE
Length = 353
Score = 147 bits (370), Expect = 3e-35
Identities = 94/305 (30%), Positives = 158/305 (50%), Gaps = 38/305 (12%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTR-TLRELKLLKFFHSHEN 71
Y + +GEG+YG V ++ T VAIKK + + LRE+++LK H+N
Sbjct: 4 YDRLSKLGEGSYGVVYKCKNRDTGQIVAIKKFVETEDDPHIKKIALREIRMLKQL-KHQN 62
Query: 72 IISVLDIVRPTSWHKFEAVYLVQELMET----DLQKIINQQNLSEDHIQYFVYQILRALK 127
++ ++++ + + ++LV EL + +L+K N ++++ I+ +YQ+L ALK
Sbjct: 63 LVGLIEVFK-----RNRKLHLVFELCDRTVLHELEK--NPHGVNDELIKKIIYQLLEALK 115
Query: 128 SLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYR 187
HS + IHRD+KP N+ L N +K+ DFG AR + N T+YVATRWYR
Sbjct: 116 FCHSHKCIHRDVKPENIFLTRNDQVKLGDFGFARII--------NTTEMYTDYVATRWYR 167
Query: 188 APEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQ 247
+PE+++ +Y +DIW+ GC+ AE++ G+ L+PG+ QL+ I + LG
Sbjct: 168 SPELLVGDVQYGPPVDIWAVGCVYAELLTGEALWPGRSDIDQLYHIRKTLGEFLPRHISI 227
Query: 248 IKSKR--------AKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAV 299
++ + E++ LP K +P + +D L K +PD+R S
Sbjct: 228 FRTNQFFFGLSIPEPEHLEPLPSK--LP-------NASSAQLDFLQKCFEMSPDRRFSCS 278
Query: 300 EALEH 304
E + H
Sbjct: 279 ELMLH 283
>CE11556 [DKL] KOG0659 Cdk activating kinase (CAK)/RNA polymerase II
transcription initiation/nucleotide excision repair
factor TFIIH/TFIIK kinase subunit CDK7
Length = 305
Score = 147 bits (370), Expect = 3e-35
Identities = 104/334 (31%), Positives = 165/334 (49%), Gaps = 43/334 (12%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTLRELKLLKFFHSHENI 72
Y+ + + G GA+G V A T+ +VAIK+I + S RE+ L+ H H NI
Sbjct: 8 YETIQVAGRGAFGLVVIARDTLTSKRVAIKRIMVPNVSK--VSLAREISCLRNLH-HRNI 64
Query: 73 ISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQNLSEDHIQYFVYQILRALKSLHSA 132
+ +LD DL I+ + E ++ QIL + LHS
Sbjct: 65 LKLLDC-----------------FPSADLMSIVTE----EVPYTWYYTQILSGIAYLHSK 103
Query: 133 QVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRAPEIM 192
+++HRD+KP N+L+ S +K+ DFG A D ++E V VATRWYRAPE++
Sbjct: 104 EIMHRDIKPENILVTSRNVVKIADFGQACFYMPKDPNQEYDVN-----VATRWYRAPELL 158
Query: 193 LSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQIKSKR 252
++Y +DIW+ GCILAE++ GKP+FPG+ Q+ II VLG+P +++ ++
Sbjct: 159 FGSKKYKPDVDIWAIGCILAELVRGKPIFPGRSELEQISIIFGVLGTPNEDNWPNWRTMP 218
Query: 253 AKEYISQLPMKKGIPWANV-LNKEVNPLAIDLLSKMLTFNPDKRISAVEALEHPYLATYH 311
+ P + W + L KE++ + L L F KR+ A E L+ P++
Sbjct: 219 DANKLLFEPKEPRNNWTEILLCKEISNNFTEFLGSHLQF--FKRLKASELLKEPWI-KQG 275
Query: 312 DPDDEPDYPQLNLEDNFWKIDNEARDKNEEDDIP 345
P EP+Y +I ++ +N+ D +P
Sbjct: 276 LPLVEPNY----------RISKKSTRRNQRDALP 299
>Hs4503097 [TDK] KOG0668 Casein kinase II alpha subunit
Length = 350
Score = 146 bits (369), Expect = 4e-35
Identities = 97/305 (31%), Positives = 172/305 (55%), Gaps = 31/305 (10%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTLRELKLLKFFHSHENI 72
YQLV +G G Y V AI+ N +V +K ++P + + RE+K+L+ NI
Sbjct: 40 YQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKK----KIKREVKILENLRGGTNI 95
Query: 73 ISVLDIVR-PTSWHKFEAVYLVQELMETDLQKIINQQNLSEDHIQYFVYQILRALKSLHS 131
I ++D V+ P S K A+ + + + TD +++ Q L++ I++++Y++L+AL HS
Sbjct: 96 IKLIDTVKDPVS--KTPAL-VFEYINNTDFKQLY--QILTDFDIRFYMYELLKALDYCHS 150
Query: 132 AQVIHRDLKPSNLLLN-SNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRAPE 190
++HRD+KP N++++ L++ D+GLA + + VA+R+++ PE
Sbjct: 151 KGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVR--------VASRYFKGPE 202
Query: 191 IMLSFQEYTTAMDIWSCGCILAEMIMGK-PLFPGKDYHHQLWIILEVLGSPT----LEDF 245
+++ +Q Y ++D+WS GC+LA MI + P F G+D + QL I +VLG+ L+ +
Sbjct: 203 LLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKY 262
Query: 246 EQIKSKRAKEYISQLPMKKGIPWANVLNKE----VNPLAIDLLSKMLTFNPDKRISAVEA 301
+ + Q K+ W N ++ E V+P A+DLL K+L ++ +R++A EA
Sbjct: 263 HIDLDPHFNDILGQHSRKR---WENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEA 319
Query: 302 LEHPY 306
+EHPY
Sbjct: 320 MEHPY 324
>At4g10010 [D] KOG0600 Cdc2-related protein kinase
Length = 649
Score = 146 bits (369), Expect = 4e-35
Identities = 107/336 (31%), Positives = 170/336 (49%), Gaps = 22/336 (6%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTL-RELKLLKFFHSHEN 71
++ +D +G+G Y +V A T VA+KK++ + R + RE+ +L+ H N
Sbjct: 156 FEKLDKIGQGTYSSVYRARDLETGKMVAMKKVRFVNMDPESVRFMAREINILRKL-DHPN 214
Query: 72 IISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQNL--SEDHIQYFVYQILRALKSL 129
++ + +V ++YLV E ME DL + + + +E I+ ++ Q+L L+
Sbjct: 215 VMKLECLVTSKL---SGSLYLVFEYMEHDLSGLALRPGVKFTESQIKCYMKQLLSGLEHC 271
Query: 130 HSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCL-ASSDQSRENMVGFMTEYVATRWYRA 188
HS ++HRD+K NLL+N++ LK+ DFGLA DQ +T V T WYRA
Sbjct: 272 HSRGILHRDIKGPNLLVNNDGVLKIGDFGLANIYHPEQDQP-------LTSRVVTLWYRA 324
Query: 189 PEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQI 248
PE++L EY +D+WS GCIL E+ +GKP+ PG+ Q+ I + GSP+ + +++
Sbjct: 325 PELLLGATEYGPGIDLWSVGCILTELFLGKPIMPGRTEVEQMHKIFKFCGSPSDDYWQKT 384
Query: 249 KSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEHPYLA 308
K A + Q P K+ + K + P A+ L+ K+L+ P KR +A L +
Sbjct: 385 KLPLATSFKPQQPYKRVL---LETFKNLPPSALALVDKLLSLEPAKRGTASSTLSSKFFT 441
Query: 309 TYHDP---DDEPDYPQLNLEDNFWKIDNEARDKNEE 341
P P YP D + D EAR K E
Sbjct: 442 MEPLPCNVSSLPKYPPSKELDAKVR-DEEARRKKSE 476
>YKL139w [D] KOG0600 Cdc2-related protein kinase
Length = 528
Score = 146 bits (368), Expect = 5e-35
Identities = 97/321 (30%), Positives = 162/321 (50%), Gaps = 38/321 (11%)
Query: 11 SHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQ-PFSRSMFVTRTLRELKLLKFFHSH 69
S Y + VGEG YG V A + T VA+KK++ R F ++RE+KLL+ F H
Sbjct: 181 SVYLRIMQVGEGTYGKVYKAKNTNTEKLVALKKLRLQGEREGFPITSIREIKLLQSF-DH 239
Query: 70 ENIISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQNLSEDHIQ--YFVYQILRALK 127
N+ ++ +I+ + + VY++ E + DL ++ + + H Q + Q+L ++
Sbjct: 240 PNVSTIKEIMVESQ----KTVYMIFEYADNDLSGLLLNKEVQISHSQCKHLFKQLLLGME 295
Query: 128 SLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYR 187
LH +++HRD+K SN+L+++ +LK+ DFGLAR + N T V T WYR
Sbjct: 296 YLHDNKILHRDVKGSNILIDNQGNLKITDFGLAR--------KMNSRADYTNRVITLWYR 347
Query: 188 APEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLED--- 244
PE++L Y T +D+W CGC+L E+ +F G + Q+ I +++G+PT+
Sbjct: 348 PPELLLGTTNYGTEVDMWGCGCLLVELFNKTAIFQGSNELEQIESIFKIMGTPTINSWPT 407
Query: 245 ------FEQIKSKRAKEYISQL--PMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRI 296
F I ++ +Y++ K +P + L +N +L ++ KR
Sbjct: 408 LYDMPWFFMIMPQQTTKYVNNFSEKFKSVLPSSKCLQLAIN---------LLCYDQTKRF 458
Query: 297 SAVEALEHPYLATYHDPDDEP 317
SA EAL+ Y +P EP
Sbjct: 459 SATEALQSDYFK--EEPKPEP 477
>At5g39420 [D] KOG0600 Cdc2-related protein kinase
Length = 576
Score = 145 bits (367), Expect = 7e-35
Identities = 100/328 (30%), Positives = 170/328 (51%), Gaps = 24/328 (7%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKI-----QPFSRSMFVTRTLRELKLLKFFH 67
+Q ++ +G+G Y +V A T VA+KK+ QP S F+ R + L+ L
Sbjct: 105 FQKLEKIGQGTYSSVFRAREVETGKMVALKKVKFDNLQPES-IRFMAREILILRKL---- 159
Query: 68 SHENIISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQNL--SEDHIQYFVYQILRA 125
+H NI+ + IV + ++YLV E ME DL + + ++ +E I+ ++ Q+L
Sbjct: 160 NHPNIMKLEGIVTSRA---SSSIYLVFEYMEHDLAGLSSNPDIRFTEPQIKCYMKQLLWG 216
Query: 126 LKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRW 185
L+ H VIHRD+K SN+L+N+ LK+ DFGLA + S++++ +T V T W
Sbjct: 217 LEHCHMRGVIHRDIKASNILVNNKGVLKLGDFGLANVVTPSNKNQ------LTSRVVTLW 270
Query: 186 YRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDF 245
YRAPE+++ Y ++D+WS GC+ AE++MGKP+ G+ QL I ++ GSP +
Sbjct: 271 YRAPELLMGSTSYGVSVDLWSVGCVFAEILMGKPILKGRTEIEQLHKIYKLCGSPQDSFW 330
Query: 246 EQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEHP 305
++ K A + Q + + K+++ + LL +L+ PDKR +A AL
Sbjct: 331 KRTKLPHATSFKPQHTYEATL---RERCKDLSATGVYLLETLLSMEPDKRGTASSALNSE 387
Query: 306 YLATYHDPDDEPDYPQLNLEDNFWKIDN 333
+ +E N++K+ +
Sbjct: 388 DTLEVKNIPNEASRATTTTHGNYYKVSD 415
>At1g57700 [D] KOG0600 Cdc2-related protein kinase
Length = 686
Score = 145 bits (367), Expect = 7e-35
Identities = 97/317 (30%), Positives = 165/317 (51%), Gaps = 18/317 (5%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTL-RELKLLKFFHSHEN 71
++ ++++G+G Y +V A TN VA+KK++ + R + RE+ +L+ + H N
Sbjct: 146 FEKLEMIGQGTYSSVYRARDLETNQIVALKKVRFANMDPESVRFMAREIIILRRLN-HPN 204
Query: 72 IISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQNLSEDHIQYFVYQILRALKSLHS 131
++ + ++ + ++YL+ E M+ DL + + + Q Q+L L+ HS
Sbjct: 205 VMKLEGLIISKA---SGSMYLIFEYMDHDLAGLASTPGIKFSQAQ----QLLLGLEHCHS 257
Query: 132 AQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRAPEI 191
V+HRD+K SNLLL+ N +LK+ DFGL+ + +T V T WYR PE+
Sbjct: 258 CGVLHRDIKCSNLLLDRNNNLKIGDFGLSNFYRGQRKQP------LTSRVVTLWYRPPEL 311
Query: 192 MLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQIKSK 251
+L +Y +D+WS GCILAE+ GKPL PG+ Q+ I ++ GSP+ E + + + +
Sbjct: 312 LLGSTDYGVTVDLWSTGCILAELFTGKPLLPGRTEVEQMHKIFKLCGSPSEEYWRRSRLR 371
Query: 252 RAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEHPYLATYH 311
A + Q P K+ + A+ K++ A+ LL +L PD R +A AL+ + T
Sbjct: 372 HATIFKPQHPYKRCV--ADTF-KDLPSSALALLEVLLAVEPDARGTASSALQSEFFTTKP 428
Query: 312 DPDDEPDYPQLNLEDNF 328
P + P+ F
Sbjct: 429 FPSEPSSLPRYQPRKEF 445
>At1g54610 [D] KOG0600 Cdc2-related protein kinase
Length = 572
Score = 145 bits (367), Expect = 7e-35
Identities = 102/336 (30%), Positives = 170/336 (50%), Gaps = 33/336 (9%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKI-----QPFSRSMFVTRTLRELKLLKFFH 67
++ +D +G+G Y V A T VA+KK+ +P S F+ R + L+ L
Sbjct: 118 FEKIDKIGQGTYSNVYKAKDMLTGKIVALKKVRFDNLEPESVK-FMAREILVLRRL---- 172
Query: 68 SHENIISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQ--NLSEDHIQYFVYQILRA 125
H N++ + +V ++YLV + M+ DL + + SE ++ + Q++
Sbjct: 173 DHPNVVKLEGLVTS---RMSCSLYLVFQYMDHDLAGLASSPVVKFSESEVKCLMRQLISG 229
Query: 126 LKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRW 185
L+ HS V+HRD+K SNLL++ LK+ DFGLA + + MT V T W
Sbjct: 230 LEHCHSRGVLHRDIKGSNLLIDDGGVLKIADFGLATIFDPNHKRP------MTSRVVTLW 283
Query: 186 YRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDF 245
YRAPE++L +Y +D+WS GCILAE++ G+P+ PG+ QL I ++ GSP+ + +
Sbjct: 284 YRAPELLLGATDYGVGIDLWSAGCILAELLAGRPIMPGRTEVEQLHKIYKLCGSPSEDYW 343
Query: 246 EQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEHP 305
++ K Y + P K+ I K+ P ++ L+ +L+ P+ R +A AL+
Sbjct: 344 KKGKFTHGAIYKPREPYKRSI---RETFKDFPPSSLPLIDALLSIEPEDRQTASAALKSE 400
Query: 306 YLATYH---DPDDEPDYPQLNLEDNFWKIDNEARDK 338
+ + +P D P YP +ID + RD+
Sbjct: 401 FFTSEPYACEPADLPKYPPSK------EIDAKRRDE 430
>Hs17461944 [R] KOG0593 Predicted protein kinase KKIAMRE
Length = 385
Score = 145 bits (366), Expect = 9e-35
Identities = 100/351 (28%), Positives = 170/351 (47%), Gaps = 54/351 (15%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTR-TLRELKLLKFFHSHEN 71
Y+ + GEG+YG V +K + VA+KK V + LRE+++LK H N
Sbjct: 4 YEKLAKTGEGSYGVVFKCRNKTSGQVVAVKKFVESEDDPVVKKIALREIRMLKQL-KHPN 62
Query: 72 IISVLDIVRPTSWHKFEAVY------LVQEL------METD-----LQKIINQQNLSEDH 114
+++++++ R K V+ L+ EL M++D L+ + ++ L+ +
Sbjct: 63 LVNLIEVFRRK--RKMHLVFEYCDHTLLNELERNPNGMDSDSIVGRLRSVADRSRLAPKN 120
Query: 115 IQYFVYQILRALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMV 174
Q + Q IHRD+KP N+L+ +K+CDFG A+ L D
Sbjct: 121 NQIMILQC------------IHRDIKPENILITKQGIIKICDFGFAQILIPGDA------ 162
Query: 175 GFMTEYVATRWYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIIL 234
T+YVATRWYRAPE+++ +Y +++DIW+ GC+ AE++ G+PL+PGK QL++I+
Sbjct: 163 --YTDYVATRWYRAPELLVGDTQYGSSVDIWAIGCVFAELLTGQPLWPGKSDVDQLYLII 220
Query: 235 EVLGSPTLEDFEQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDK 294
LG KS IS +P + + +V+P+A++ + L NPD
Sbjct: 221 RTLGKLIPRHQSIFKSNGFFHGIS-IPEPEDMETLEEKFSDVHPVALNFMKGCLKMNPDD 279
Query: 295 RISAVEALEHPYLATYHDPDDEPDYPQLNLEDNFWKIDNEARDKNEEDDIP 345
R++ + LE Y ++ + + K NE R++ + P
Sbjct: 280 RLTCSQLLESSYFDSFQEAQIKR------------KARNEGRNRRRQQQAP 318
>At3g50000 [TDK] KOG0668 Casein kinase II alpha subunit
Length = 333
Score = 145 bits (366), Expect = 9e-35
Identities = 97/306 (31%), Positives = 161/306 (51%), Gaps = 29/306 (9%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTLRELKLLKFFHSHENI 72
Y++V VG G Y V I+ N K IK ++P + + RE+K+L+ NI
Sbjct: 34 YEVVRKVGRGKYSEVFEGINMNNNEKCIIKILKPVKKK----KIRREIKILQNLCGGPNI 89
Query: 73 ISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQNLSEDHIQYFVYQILRALKSLHSA 132
+ +LD+VR H + + + TD + + L++ I+Y++Y++L+AL HS
Sbjct: 90 VKLLDVVRDQ--HSKTPSLIFEYVNSTDFKVLY--PTLTDYDIRYYIYELLKALDFCHSQ 145
Query: 133 QVIHRDLKPSNLLLNSNC-DLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRAPEI 191
++HRD+KP N++++ L++ D+GLA + VA+R+++ PE+
Sbjct: 146 GIMHRDVKPHNVMIDHELRKLRLIDWGLAEFYHPGKEYNVR--------VASRYFKGPEL 197
Query: 192 MLSFQEYTTAMDIWSCGCILAEMIMGK-PLFPGKDYHHQLWIILEVLGSPTLEDFEQIKS 250
++ Q+Y ++D+WS GC+ A MI K P F G D QL I +VLG+ L + +
Sbjct: 198 LVDLQDYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNQDQLVKIAKVLGTDELNAY---LN 254
Query: 251 KRAKEYISQLPMKKG----IPWANVLNKE----VNPLAIDLLSKMLTFNPDKRISAVEAL 302
K E +QL G PW+ +N + V+P AID L K+L ++ R++A EA+
Sbjct: 255 KYQLELDTQLEALVGRHSRKPWSKFINADNRHLVSPEAIDYLDKLLRYDHQDRLTAKEAM 314
Query: 303 EHPYLA 308
HPY A
Sbjct: 315 AHPYFA 320
>YDL079c [G] KOG0658 Glycogen synthase kinase-3
Length = 501
Score = 144 bits (364), Expect = 2e-34
Identities = 95/307 (30%), Positives = 164/307 (52%), Gaps = 29/307 (9%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTLRELKLLKFFHSHENI 72
Y ++VG G++G V + + TN KVAIKK+ R + R L +K+L H N
Sbjct: 164 YPTTEVVGHGSFGVVVTTVIIETNQKVAIKKVLQDRR--YKNRELETMKML----CHPNT 217
Query: 73 ISVLDIVRPTSWHKFEAVYLVQELMETDL-QKIINQQNLSED----HIQYFVYQILRALK 127
+ + + LV + M L Q++ + NL I+++ YQ+ +AL
Sbjct: 218 VGLQYYFYEKDEEDEVYLNLVLDYMPQSLYQRLRHFVNLKMQMPRVEIKFYAYQLFKALN 277
Query: 128 SLHSA-QVIHRDLKPSNLLLN-SNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRW 185
LH+ ++ HRD+KP NLL++ + K+CDFG A+CL + Y+ +R+
Sbjct: 278 YLHNVPRICHRDIKPQNLLVDPTTFSFKICDFGSAKCLKPDQPN--------VSYICSRY 329
Query: 186 YRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDF 245
YRAPE+M Y+ +D+WS C++AE+++GKPLF G+ QL I++++G PT ++
Sbjct: 330 YRAPELMFGATNYSNQVDVWSSACVIAELLLGKPLFSGESGIDQLVEIIKIMGIPTKDEI 389
Query: 246 EQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEHP 305
+ + ++++ P K I A + E +P +DLL+K L ++P +R+ ++ L
Sbjct: 390 SGM-NPNYEDHV--FPNIKPITLAEIFKAE-DPDTLDLLTKTLKYHPCERLVPLQCL--- 442
Query: 306 YLATYHD 312
L++Y D
Sbjct: 443 -LSSYFD 448
>SPAC23H4.17c [K] KOG0666 Cyclin C-dependent kinase CDK8
Length = 352
Score = 144 bits (363), Expect = 2e-34
Identities = 100/332 (30%), Positives = 169/332 (50%), Gaps = 50/332 (15%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTK--VAIKKIQPFSRSMFVTR--------TLRELKL 62
Y+++ + G YG V A+ +N K AIKK + S+ + +RE+ L
Sbjct: 5 YKIIGFISSGTYGKVYKAVSSNSNDKRLFAIKKFKAESKQVSSNAQQTGVSQSAIREMML 64
Query: 63 LKFFHSHENIISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQNLSEDH------IQ 116
+ HENI+S++ ++ K + +V E E DL +II+ + S ++
Sbjct: 65 CREIQ-HENIVSLVQVLL-----KDGTISMVFEYAEHDLLQIIHFHSRSRTRQIPPSILK 118
Query: 117 YFVYQILRALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGF 176
++QI+ + LH ++HRDLKP+N+++ + +K+ D GL R + R+ ++ F
Sbjct: 119 SILWQIINGVAYLHENWIMHRDLKPANIMITATGKVKIGDLGLGRLI------RDPILPF 172
Query: 177 MTE--YVATRWYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKD--------- 225
+ V T WYRAPE++L +YT A+D+W+ GCI EM+ PLF G +
Sbjct: 173 YSSDRVVVTIWYRAPELLLGAHDYTPAIDVWAIGCIYGEMLALSPLFKGDEIKMEDKKVV 232
Query: 226 --YHHQLWIILEVLGSPTLEDFEQIKSKRAKEYISQLPMKKGIPWANVLN------KEVN 277
Q+ I+E+LG+PT E + +K+ +S ++ W N+L K +
Sbjct: 233 PFQSTQMLRIMELLGTPTEERWPGLKNYPEYYQLSSFEVRY---WNNLLPQWYQTVKNRD 289
Query: 278 PLAIDLLSKMLTFNPDKRISAVEALEHPYLAT 309
P +DLL KML ++P RI+A +ALEH + +
Sbjct: 290 PQGLDLLMKMLQYDPKSRITAKQALEHVFFTS 321
>SPAC3C7.06c [T] KOG0661 MAPK related serine/threonine protein kinase
Length = 650
Score = 143 bits (361), Expect = 3e-34
Identities = 99/335 (29%), Positives = 170/335 (50%), Gaps = 32/335 (9%)
Query: 13 YQLVDLVGEGAYGTVCSAIHK-PTNTKVAIKKIQPFSRSMFVTRTLRELKLLKFFHSHEN 71
Y +V VG+G +G+V A K P+ VAIK ++ + LRE+ L +EN
Sbjct: 36 YNVVRKVGDGTFGSVYLATTKTPSKEVVAIKSMKKKLAKVSDATRLREVHSLLRLSENEN 95
Query: 72 IISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQN---LSEDHIQYFVYQILRALKS 128
I+++ D+ +F +++V E ++ +L ++I+ + L+ + +Q + QI + L
Sbjct: 96 IVNIFDLYID----QFRCLHIVMEFLDCNLYQLISTRKNDPLTLEQVQDIMRQIFKGLNH 151
Query: 129 LHSAQVIHRDLKPSNLLLNSNCD-----LKVCDFGLARCLASSDQSRENMVGFMTEYVAT 183
+H+ HRD+KP N+L++SN D +K+ DFGLAR + S TEYV+T
Sbjct: 152 IHTNGFFHRDMKPENILISSNSDSSSFNVKIADFGLAREINSRPP--------YTEYVST 203
Query: 184 RWYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLE 243
RWYRAPE++L Y+ +DI++ GC+ E+ +P+FPG D QL+ + E+LGSP E
Sbjct: 204 RWYRAPELLLRDSYYSFPVDIYAAGCMAFEIATLQPIFPGNDDFDQLYKMCEILGSPD-E 262
Query: 244 DFEQIKSK----------RAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPD 293
+ K A + LP + + ++ + N +LS++L ++P
Sbjct: 263 QSQNTGDKGGGIWDRAELLANKLGISLPKMAPLDFGDLFSPPWNLAFASMLSQLLKWDPA 322
Query: 294 KRISAVEALEHPYLATYHDPDDEPDYPQLNLEDNF 328
KR +A L+ + D ++N +F
Sbjct: 323 KRPTAEMCLDLEFCRVSAPADAVASKEEVNKNTDF 357
>ECU11g1290 [R] KOG0663 Protein kinase PITSLRE and related kinases
Length = 328
Score = 143 bits (361), Expect = 3e-34
Identities = 95/308 (30%), Positives = 153/308 (48%), Gaps = 35/308 (11%)
Query: 12 HYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQP---FSRSMFVTRTLRELKLLKFFHS 68
+Y+ V + G++G V K N A+K++ P + + F +RE+ +LK
Sbjct: 25 NYEKVCRISSGSFGNVYRVRRKTDNRVFALKRMNPSMCYDTNGFSILYIREVMILKHIR- 83
Query: 69 HENIISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQN-LSEDHIQYFVYQILRALK 127
H NI+ + ++V + F ++V E +TDL+ +I+ + ++ Q+L+ LK
Sbjct: 84 HRNIMEIEEVVEGCEINDF---FIVMECCDTDLRSVIHSVGKIGMKAARFLTCQMLKGLK 140
Query: 128 SLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYR 187
LH A ++HRDLKPSN+LL + L++ DFGLAR + S MT V T WYR
Sbjct: 141 FLHGAGIVHRDLKPSNILLMRDGGLRIADFGLARAIESQ----------MTNLVVTLWYR 190
Query: 188 APEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQ 247
EI+L + Y ++D+WS GC++ EM+ G+P+ G+ QL I +LG PT DFE
Sbjct: 191 PIEILLGSETYDESIDMWSVGCVVGEMLRGEPILAGEGEMDQLDRIFRLLGYPTDADFEG 250
Query: 248 IKSKRAKEYISQLPMKKGIPWANVLNKE-------VNPLAIDLLSKMLTFNPDKRISAVE 300
+ LP K I + A + +L+F+P KR +A +
Sbjct: 251 L----------DLPHFKNIRRPSTFEASFEGDFECYGEEAASFVRNLLSFDPRKRCTASQ 300
Query: 301 ALEHPYLA 308
L ++A
Sbjct: 301 GLCSGFVA 308
>At2g23080 [TDK] KOG0668 Casein kinase II alpha subunit
Length = 333
Score = 143 bits (360), Expect = 4e-34
Identities = 97/306 (31%), Positives = 163/306 (52%), Gaps = 29/306 (9%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTLRELKLLKFFHSHENI 72
Y++V VG G Y V + TN + IK ++P + + RE+K+L+ NI
Sbjct: 34 YEVVRKVGRGKYSEVFEGKNVNTNERCVIKILKPVKKK----KIKREIKILQNLCGGPNI 89
Query: 73 ISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQNLSEDHIQYFVYQILRALKSLHSA 132
+ + DIVR + LV E + + K++ L++ I+Y++Y++L+AL HS
Sbjct: 90 VKLYDIVRD---EHSKTPSLVFEFVNSVDFKVL-YPTLTDYDIRYYIYELLKALDFCHSQ 145
Query: 133 QVIHRDLKPSNLLLNSNC-DLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRAPEI 191
++HRD+KP N++++ L++ D+GLA + VA+R+++ PE+
Sbjct: 146 GIMHRDVKPHNVMIDHQLRKLRLIDWGLAEFYHPGKEYNVR--------VASRYFKGPEL 197
Query: 192 MLSFQEYTTAMDIWSCGCILAEMIMGK-PLFPGKDYHHQLWIILEVLGSPTLEDFEQIKS 250
++ Q+Y ++D+WS GC+ A MI K P F G D H QL I +VLG+ L+ + +
Sbjct: 198 LVDLQDYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNHDQLVKIAKVLGTNELDHY---LN 254
Query: 251 KRAKEYISQLPMKKG----IPWANVLNKE----VNPLAIDLLSKMLTFNPDKRISAVEAL 302
K + QL G PW+ +N + V+P AID L K+L ++ R++A EA+
Sbjct: 255 KYQLDLDPQLEALVGRHVPKPWSKFINADNQHLVSPEAIDFLDKLLQYDHQDRLTAREAM 314
Query: 303 EHPYLA 308
+HPY A
Sbjct: 315 DHPYFA 320
>At1g74330 [D] KOG0600 Cdc2-related protein kinase
Length = 445
Score = 142 bits (359), Expect = 6e-34
Identities = 103/336 (30%), Positives = 171/336 (50%), Gaps = 31/336 (9%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKI-----QPFSRSMFVTRTLRELKLLKFFH 67
++ ++ +G+G Y V A+ T VA+KK+ +P S F+ R + L+ L
Sbjct: 121 FEKLEKIGQGTYSNVFRAVETETGRIVALKKVRFDNFEPESVK-FMAREILILRRL---- 175
Query: 68 SHENIISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQNL--SEDHIQYFVYQILRA 125
+H NII + ++ + V+ E ME DL +++ ++ + I+ ++ Q+L
Sbjct: 176 NHPNIIKLEGLITSKLSCNIQLVF---EYMEHDLTGLLSSPDIKFTTPQIKCYMKQLLSG 232
Query: 126 LKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRW 185
L HS V+HRD+K SNLLL++ LKV DFGLA SS ++ + T V T W
Sbjct: 233 LDHCHSRGVMHRDIKGSNLLLSNEGILKVADFGLANFSNSSGHKKKPL----TSRVVTLW 288
Query: 186 YRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDF 245
YR PE++L +Y ++D+WS GC+ AE+++GKP+ G+ QL I ++ GSP + +
Sbjct: 289 YRPPELLLGATDYGASVDLWSVGCVFAELLLGKPILRGRTEVEQLHKIFKLCGSPPEDYW 348
Query: 246 EQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEHP 305
++ K A + P + K+++ I+L+ +L+ +P KR +A AL
Sbjct: 349 KKSKLPHAMLF---KPQQTYDSCLRETLKDLSETEINLIETLLSIDPHKRGTASSALVSQ 405
Query: 306 YLATYH---DPDDEPDYPQLNLEDNFWKIDNEARDK 338
Y T DP P YP +ID + RD+
Sbjct: 406 YFTTKPFACDPSSLPIYPPSK------EIDTKHRDE 435
>ECU02g1450 [DKL] KOG0659 Cdk activating kinase (CAK)/RNA polymerase II
transcription initiation/nucleotide excision repair
factor TFIIH/TFIIK kinase subunit CDK7
Length = 308
Score = 142 bits (357), Expect = 1e-33
Identities = 89/278 (32%), Positives = 147/278 (52%), Gaps = 23/278 (8%)
Query: 39 VAIKKIQPFSRSM-FVTRTLRELKLLKFFHSHENIISVLDIVRPTSWHKFEAVYLVQELM 97
VAIKKI+P + +RE+K LK S + ++ ++D ++ + V++V E +
Sbjct: 43 VAIKKIKPTKYTQGHEISAIREIKSLKRIDS-KYVVRLID-----TFVYDKCVHIVLEYV 96
Query: 98 ETDLQKIINQQN--LSEDHIQYFVYQILRALKSLHSAQVIHRDLKPSNLLLNSNCDLKVC 155
ET+L+ +I + + I+ ++ +LR + H +IHRD+KP+N+L+ S +K+
Sbjct: 97 ETNLENVIRNSDKIIMPGDIKAWILMVLRGVYECHRLFIIHRDIKPNNILITSEGMVKLA 156
Query: 156 DFGLARCLASSDQSRENMVGFMTEYVATRWYRAPEIMLSFQEYTTAMDIWSCGCILAEMI 215
DFGL R + + MT TRWYRAPE+++ ++Y + +D+WS GC+ AE+
Sbjct: 157 DFGLTRGIGNR----------MTPQAVTRWYRAPELLMGSRDYGSPVDMWSVGCVFAELF 206
Query: 216 MGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQIKSKRAKEYISQLPMKKGIPWANVLNKE 275
+ PLF G QL +I LG+P ++ + + Q P N L
Sbjct: 207 LRVPLFAGDTDIQQLDMIFRALGTPVEREWPGVSTLPEFLDFQQYPKAS----LNGLFSA 262
Query: 276 VNPLAIDLLSKMLTFNPDKRISAVEALEHPYLATYHDP 313
+ A+DLL K+LT NP RIS +A++HPY + P
Sbjct: 263 ASSDALDLLEKLLTLNPCNRISCDDAIKHPYFKSSPPP 300
>CE26988 [DKL] KOG0659 Cdk activating kinase (CAK)/RNA polymerase II
transcription initiation/nucleotide excision repair
factor TFIIH/TFIIK kinase subunit CDK7
Length = 308
Score = 142 bits (357), Expect = 1e-33
Identities = 99/303 (32%), Positives = 154/303 (50%), Gaps = 44/303 (14%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMF---VTRT-LRELKLLKFFHS 68
Y + +GEG + V A + VAIKKI+ SR + RT +RE+KLLK H
Sbjct: 5 YDTIKHLGEGQFANVYLAQDLESGECVAIKKIKLGSREEAKDGINRTAIREIKLLKEIH- 63
Query: 69 HENIISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQN--LSEDHIQYFVYQILRAL 126
H+NII + D++ + ++ LV + M+TDL+ +I + L HI+ Q+L L
Sbjct: 64 HDNIIGLRDVIGHRT-----SIQLVFDFMDTDLEHVIKDKEIILMPAHIKNITMQMLLGL 118
Query: 127 KSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWY 186
+ LH ++HRDLKP+NLL+N + R V TRWY
Sbjct: 119 EFLHVHWILHRDLKPNNLLMNK----------MGR-------------------VVTRWY 149
Query: 187 RAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFE 246
RAPE++ + Y +DIWS GCI+AE+++ P+FPG+ QL I +LG PT E +
Sbjct: 150 RAPELLFGARSYGVGIDIWSVGCIIAELLLRNPIFPGESDIDQLVKIFNILGCPTPETWP 209
Query: 247 QIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEHPY 306
+ + Y+ P + + + L +DL++ M TF+P KR++ ++L+ Y
Sbjct: 210 NMTEMNS--YVIIKPQTEYMALNYYFSAAPQDL-LDLMAGMWTFDPIKRLTCTQSLQMEY 266
Query: 307 LAT 309
T
Sbjct: 267 FRT 269
>ECU11g0960 [D] KOG0600 Cdc2-related protein kinase
Length = 329
Score = 141 bits (356), Expect = 1e-33
Identities = 90/300 (30%), Positives = 155/300 (51%), Gaps = 31/300 (10%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTLRELKLLKFFHSHENI 72
Y+ + ++GEG +G V A + + A+KK+ + VT T+RE+++L+ H +I
Sbjct: 22 YEKIRIIGEGTFGQVILA--RKGRARYALKKVSKEKEGLSVT-TIREVQVLRAM-GHPSI 77
Query: 73 ISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQNLSEDHIQYFVYQILRALKSLHSA 132
+ ++++V +Y+V DL + I ++ I++ YQI + + +HS
Sbjct: 78 VRLIEVVVEPGGD----IYMVFPYFPYDLNRFIRSNKMTCSEIKHIFYQIAQGVCYIHSK 133
Query: 133 QVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRAPEIM 192
++HRDLK +N+LL+ + + DFG+AR + G T + T WYRAPEI+
Sbjct: 134 GIMHRDLKSANILLDQKLNASIADFGMARYTTKT--------GAYTPGMVTLWYRAPEIL 185
Query: 193 LSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGS------PTLEDFE 246
L YT A+DIWS GCIL EM +G +F G QL +++ GS P ++D
Sbjct: 186 LGSSSYTYAVDIWSLGCILTEMYLGHMIFQGSTEMLQLEMVIHACGSINENSYPGVQDLP 245
Query: 247 QIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEHPY 306
++ R + Q P + + ++ + A++L+SKML +P KRI+ + + Y
Sbjct: 246 GFRNFR----LPQSPRR-----IEGIIRKHDASAVELVSKMLCLDPSKRITVEQVVGSKY 296
>At2g23070 [TDK] KOG0668 Casein kinase II alpha subunit
Length = 432
Score = 141 bits (356), Expect = 1e-33
Identities = 91/309 (29%), Positives = 160/309 (51%), Gaps = 23/309 (7%)
Query: 5 ITYDIPSHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTLRELKLLK 64
+ + + Y++V VG G Y V IH N K IK ++P + + RE+K+L+
Sbjct: 124 VQWGVQDDYEVVRKVGRGKYSEVFEGIHATDNEKCVIKILKPVKKK----KIKREIKILQ 179
Query: 65 FFHSHENIISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQNLSEDHIQYFVYQILR 124
NI+ +LDIVR + + L+ E + K++ LS+ ++Y+++++L+
Sbjct: 180 NLCGGPNIVKLLDIVRD---QQSKTPSLIFEHVNNKDFKVL-YPTLSDYDVRYYIFELLK 235
Query: 125 ALKSLHSAQVIHRDLKPSNLLLN-SNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVAT 183
AL HS ++HRD+KP N++++ L++ D+GLA + VA+
Sbjct: 236 ALDFCHSRGIMHRDVKPHNVMIDHEQRKLRLIDWGLAEFYHPGKEYNVR--------VAS 287
Query: 184 RWYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGK-PLFPGKDYHHQLWIILEVLGSPTL 242
R+++ PE+++ Q+Y ++D+WS GC+ A MI K P F G D + QL I +VLG+ L
Sbjct: 288 RYFKGPELLVDLQDYDYSLDLWSLGCMFAGMIFRKEPFFYGHDNYDQLVKIAKVLGTDEL 347
Query: 243 EDF-EQIKSKRAKEYISQLPMKKGIPWANVLNKE----VNPLAIDLLSKMLTFNPDKRIS 297
+ + + + S + PW +N E P A+D + K+L ++ +R +
Sbjct: 348 NAYLNKYRIELDPNLTSLVGRHSRKPWTKFINSENQHLAVPEAVDFVDKLLRYDHQERPT 407
Query: 298 AVEALEHPY 306
A EA+ HPY
Sbjct: 408 AKEAMAHPY 416
>At5g67380 [TDK] KOG0668 Casein kinase II alpha subunit
Length = 333
Score = 139 bits (351), Expect = 5e-33
Identities = 95/306 (31%), Positives = 159/306 (51%), Gaps = 29/306 (9%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTLRELKLLKFFHSHENI 72
Y++V VG G Y V I+ + K IK ++P + + RE+K+L+ NI
Sbjct: 34 YEVVRKVGRGKYSEVFEGINVNSKEKCIIKILKPVKKK----KIRREIKILQNLCGGPNI 89
Query: 73 ISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQNLSEDHIQYFVYQILRALKSLHSA 132
+ +LD+VR H + + + TD + + L++ I+Y++Y++L+AL HS
Sbjct: 90 VKLLDVVRDQ--HSKTPSLIFEYVNSTDFKVLY--PTLTDYDIRYYIYELLKALDFCHSQ 145
Query: 133 QVIHRDLKPSNLLLNSNC-DLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRAPEI 191
++HRD+KP N++++ L++ D+GLA + VA+R+++ PE+
Sbjct: 146 GIMHRDVKPHNVMIDHELRKLRLIDWGLAEFYHPGKEYNVR--------VASRYFKGPEL 197
Query: 192 MLSFQEYTTAMDIWSCGCILAEMIMGK-PLFPGKDYHHQLWIILEVLGSPTLEDFEQIKS 250
++ Q+Y ++D+WS GC+ A MI K P F G D QL I +VLG+ L + +
Sbjct: 198 LVDLQDYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNQDQLVKIAKVLGTDELNAY---LN 254
Query: 251 KRAKEYISQLPMKKG----IPWANVLNKE----VNPLAIDLLSKMLTFNPDKRISAVEAL 302
K E QL G PW+ +N + V+P AID L K+L ++ R++A EA+
Sbjct: 255 KYQLELDPQLEALVGRHSRKPWSKFINADNQHLVSPEAIDFLDKLLRYDHQDRLTAKEAM 314
Query: 303 EHPYLA 308
H Y A
Sbjct: 315 AHAYFA 320
>7289745 [TDK] KOG0668 Casein kinase II alpha subunit
Length = 336
Score = 139 bits (351), Expect = 5e-33
Identities = 93/305 (30%), Positives = 165/305 (53%), Gaps = 31/305 (10%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTLRELKLLKFFHSHENI 72
YQLV +G G Y V AI+ T K +K ++P + + RE+K+L+ NI
Sbjct: 37 YQLVRKLGRGKYSEVFEAINITTTEKCVVKILKPVKKK----KIKREIKILENLRGGTNI 92
Query: 73 ISVLDIVR-PTSWHKFEAVYLVQELMETDLQKIINQQNLSEDHIQYFVYQILRALKSLHS 131
I++L +V+ P S + + + TD +++ Q L++ I+Y+++++L+AL HS
Sbjct: 93 ITLLAVVKDPVSR---TPALIFEHVNNTDFKQLY--QTLTDYEIRYYLFELLKALDYCHS 147
Query: 132 AQVIHRDLKPSNLLLN-SNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRAPE 190
++HRD+KP N++++ N L++ D+GLA + VA+R+++ PE
Sbjct: 148 MGIMHRDVKPHNVMIDHENRKLRLIDWGLAEFYHPGQEYNVR--------VASRYFKGPE 199
Query: 191 IMLSFQEYTTAMDIWSCGCILAEMIMGK-PLFPGKDYHHQLWIILEVLGSPT----LEDF 245
+++ +Q Y ++D+WS GC+LA MI K P F G D + QL I +VLG+ L+ +
Sbjct: 200 LLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEELYAYLDKY 259
Query: 246 EQIKSKRAKEYISQLPMKKGIPWANVLNKE----VNPLAIDLLSKMLTFNPDKRISAVEA 301
R + + + K+ W ++ + V+P A+D L K+L ++ R++A EA
Sbjct: 260 NIDLDPRFHDILQRHSRKR---WERFVHSDNQHLVSPEALDFLDKLLRYDHVDRLTAREA 316
Query: 302 LEHPY 306
+ HPY
Sbjct: 317 MAHPY 321
>CE17321 [TDK] KOG0668 Casein kinase II alpha subunit
Length = 360
Score = 138 bits (348), Expect = 1e-32
Identities = 91/304 (29%), Positives = 163/304 (52%), Gaps = 29/304 (9%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTLRELKLLKFFHSHENI 72
YQLV +G G Y V T+ KV +K ++P + + RE+K+L+ NI
Sbjct: 38 YQLVRKLGRGKYSEVFEGFKMSTDEKVVVKILKPVKKK----KIKREIKILENLRGGTNI 93
Query: 73 ISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQNLSEDHIQYFVYQILRALKSLHSA 132
I++LD+V+ ++ + + +D +++ Q LS+ I+Y++Y++L+AL HS
Sbjct: 94 ITLLDVVKDPISRTPALIF--EHVNNSDFKQLY--QTLSDYDIRYYLYELLKALDFCHSQ 149
Query: 133 QVIHRDLKPSNLLLNSNC-DLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRAPEI 191
++HRD+KP N+++++ +L++ D+GLA VA+R+++ PE+
Sbjct: 150 GIMHRDVKPHNVMIDAEKRELRLIDWGLAEFYHPRQDYNVR--------VASRYFKGPEL 201
Query: 192 MLSFQEYTTAMDIWSCGCILAEMIMGK-PLFPGKDYHHQLWIILEVLGSPTLED----FE 246
++ +Q Y ++D+WS GC+LA MI K P F G D + QL I +VLG+ L + +
Sbjct: 202 LVDYQCYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTDELYEYIARYH 261
Query: 247 QIKSKRAKEYISQLPMKKGIPWANVLNKE----VNPLAIDLLSKMLTFNPDKRISAVEAL 302
R + + + K+ W ++ E V P A+D L K+L ++ +R++A EA+
Sbjct: 262 IDLDPRFNDILGRHSRKR---WERFIHAENQHLVTPEALDFLDKLLRYDHAERLTAQEAM 318
Query: 303 EHPY 306
H Y
Sbjct: 319 GHEY 322
>Hs4503429 [R] KOG0667 Dual-specificity tyrosine-phosphorylation regulated
kinase
Length = 553
Score = 137 bits (345), Expect = 2e-32
Identities = 101/330 (30%), Positives = 164/330 (49%), Gaps = 49/330 (14%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTLRELKLLKFFHSHENI 72
Y+++ ++G+G++G V VA+K ++ R F + E+++L+ +
Sbjct: 174 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKR--FHRQAAEEIRILEHLKKQDKT 231
Query: 73 ISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQ---QNLSEDHIQYFVYQILRALKSL 129
S+ I S+ V + EL+ DL ++I + Q S ++ F IL++L +L
Sbjct: 232 GSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDAL 291
Query: 130 HSAQVIHRDLKPSNLLL--NSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYR 187
H ++IH DLKP N+LL + KV DFG + C + Y+ +R+YR
Sbjct: 292 HKNKIIHCDLKPENILLKHHGRSSTKVIDFG-SSCFEYQK---------LYTYIQSRFYR 341
Query: 188 APEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQ 247
APEI+L Y+T +DIWS CILAE++ G+PLFPG+D QL ++E+LG P + EQ
Sbjct: 342 APEIILG-SRYSTPIDIWSFRCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQ 400
Query: 248 IKSKRAKEYI-------------------------SQLPMKKGIP----WANVLNKEVNP 278
SKRAK +I S+ K+G P W L +
Sbjct: 401 --SKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDY 458
Query: 279 LAIDLLSKMLTFNPDKRISAVEALEHPYLA 308
L I+ L + L ++P R++ +AL HP+++
Sbjct: 459 LFIEFLKRCLHWDPSARLTPAQALRHPWIS 488
>SPAC23C11.11 [TDK] KOG0668 Casein kinase II alpha subunit
Length = 332
Score = 136 bits (343), Expect = 4e-32
Identities = 91/303 (30%), Positives = 166/303 (54%), Gaps = 25/303 (8%)
Query: 12 HYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTLRELKLLKFFHSHEN 71
+Y+++ VG G Y V ++ N+K IK ++P + RE+K+L+ N
Sbjct: 42 NYEIIRKVGRGKYSEVFEGLNVLNNSKCIIKVLKPVKYK----KIKREIKILQNLAGGPN 97
Query: 72 IISVLDIVRPTSWHKFEAVYLVQELMET-DLQKIINQQNLSEDHIQYFVYQILRALKSLH 130
IIS+LDIVR + + L+ E ++ D + + LS+ I+Y+ Y++L+AL H
Sbjct: 98 IISLLDIVRDP---ESKTPSLIFEFVDNIDFRTLY--PTLSDYDIRYYSYELLKALDFCH 152
Query: 131 SAQVIHRDLKPSNLLLN-SNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRAP 189
S ++HRD+KP N++++ L++ D+GLA + + VA+R+++ P
Sbjct: 153 SRGIMHRDVKPHNVMIDHKKRKLRLIDWGLAEFYHAGMEYNVR--------VASRYFKGP 204
Query: 190 EIMLSFQEYTTAMDIWSCGCILAEMIMGK-PLFPGKDYHHQLWIILEVLGSPTL----ED 244
E+++ F+EY ++DIWS G + A +I K F G+D + QL I +VLG+ L +
Sbjct: 205 ELLVDFREYDYSLDIWSFGVMFAALIFKKDTFFRGRDNYDQLVKIAKVLGTDELFAYVQK 264
Query: 245 FEQIKSKRAKEYISQLPMKKGIPWANVLNKEV-NPLAIDLLSKMLTFNPDKRISAVEALE 303
++ + ++ + Q P + + N N+ + N AIDLL+++L ++ +R++ EA+
Sbjct: 265 YQIVLDRQYDNILGQYPKRDWYSFVNRDNRSLANDEAIDLLNRLLRYDHQERLTCQEAMA 324
Query: 304 HPY 306
HPY
Sbjct: 325 HPY 327
>ECU08g0230 [R] KOG0594 Protein kinase PCTAIRE and related kinases
Length = 265
Score = 136 bits (343), Expect = 4e-32
Identities = 94/293 (32%), Positives = 146/293 (49%), Gaps = 38/293 (12%)
Query: 11 SHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTLRELKLLKFFHSHE 70
+ Y L L+G G YG V AI T KVA+K+I+ + LRE+ +LK SH
Sbjct: 2 TRYILGALIGSGTYGEVYEAIDTETKEKVALKRIRLNEKEGMPGTALREISILKKL-SHR 60
Query: 71 NIISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQNLSEDHIQYFVYQILRALKSLH 130
NIIS++ I+ H + +V ++ +L+K I + +I V Q++ + LH
Sbjct: 61 NIISLVSII-----HTDALLTMVFPFIDYELKKYIGMN--TGKNIMELVNQLICGVHYLH 113
Query: 131 SAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRAPE 190
V+HRDLKP N+L+ S+ LK+ DFGL+R L E V + V T WYR+PE
Sbjct: 114 RMNVVHRDLKPQNILVTSDGVLKIADFGLSRSL-------EIRVPPYSSEVVTLWYRSPE 166
Query: 191 IMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQIKS 250
+++ Y +DIWS GCI+ EMI +PLFPG+ +QL +I G+
Sbjct: 167 LLMGSTSYRFYVDIWSLGCIIYEMITLEPLFPGESKENQLTLIRRKAGT----------- 215
Query: 251 KRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALE 303
+ + + +P +++ + L FN ++RI+A E +E
Sbjct: 216 --RRSLRGMVEQRLAVP----------KFVTEIIVRCLDFNYNQRITADEIME 256
>At1g18670 [D] KOG0600 Cdc2-related protein kinase
Length = 662
Score = 136 bits (343), Expect = 4e-32
Identities = 101/315 (32%), Positives = 166/315 (52%), Gaps = 20/315 (6%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTL-RELKLLKFFHSHEN 71
++ ++ +G+G Y +V A T VA+KK++ + R + RE+ +L+ + H N
Sbjct: 131 FEKLEKIGQGTYSSVFRARETETGRIVALKKVRFDNFEPESVRFMAREILILRKLN-HPN 189
Query: 72 IISVLDIVRPTSWHKFE-AVYLVQELMETDLQKIINQQNL--SEDHIQYFVYQILRALKS 128
II + IV K +++LV E ME DL +++ ++ + I+ ++ Q+L L
Sbjct: 190 IIKLEGIVTS----KLSCSIHLVFEYMEHDLTGLLSSPDIDFTTPQIKCYMKQLLSGLDH 245
Query: 129 LHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLAR-CLASSDQSRENMVGFMTEYVATRWYR 187
H+ V+HRD+K SNLL+N+ LKV DFGLA C AS ++ +T V T WYR
Sbjct: 246 CHARGVMHRDIKGSNLLVNNEGILKVADFGLANFCNASGNKQP------LTSRVVTLWYR 299
Query: 188 APEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQ 247
PE++L EY ++D+WS GC+ AE+++GKP+ G+ QL I ++ GSP + +++
Sbjct: 300 PPELLLGATEYGASVDLWSVGCVFAELLIGKPVLQGRTEVEQLHKIFKLCGSPPEDYWKK 359
Query: 248 IKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEHPYL 307
K A + Q G + K ++ I+L+ +L+ P KR +A AL Y
Sbjct: 360 SKLPHAMLFKPQ-QHYDGCLRETLKLKGLSDADINLIETLLSIQPHKRGTASTALVSQYF 418
Query: 308 ATYH---DPDDEPDY 319
+ DP P Y
Sbjct: 419 TSKPFACDPSSLPVY 433
>7298142 [R] KOG0667 Dual-specificity tyrosine-phosphorylation regulated
kinase
Length = 722
Score = 136 bits (342), Expect = 5e-32
Identities = 104/320 (32%), Positives = 168/320 (52%), Gaps = 40/320 (12%)
Query: 9 IPSHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTLRELKLL----- 63
I Y++++++G+G++G V A+ TNT VAIK I+ ++ F+ + + EL +L
Sbjct: 194 IAFRYEILEVIGKGSFGQVIRALDHKTNTHVAIKIIR--NKKRFLNQAVVELNILDELRE 251
Query: 64 KFFHSHENIISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQN---LSEDHIQYFVY 120
K N+I +LD T + K + ELM +L ++I + N S I+ F
Sbjct: 252 KDADGSHNVIHMLDY---TYFRKHLCITF--ELMSLNLYELIKKNNYNGFSMSLIRRFCN 306
Query: 121 QILRALKSLHSAQVIHRDLKPSNLLLNS--NCDLKVCDFGLARCLASSDQSRENMVGFMT 178
I++ L+ L+ +IH DLKP N+LL + +KV DFG + C +
Sbjct: 307 SIVKCLRLLYKENIIHCDLKPENILLKQRGSSSIKVIDFG-SSCYVDRK---------IY 356
Query: 179 EYVATRWYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLG 238
Y+ +R+YR+PE++L Q Y TA+D+WS GCILAE+ G PLFPG++ QL I+EVLG
Sbjct: 357 TYIQSRFYRSPEVILGLQ-YGTAIDMWSLGCILAELYTGFPLFPGENEVEQLACIMEVLG 415
Query: 239 SPTLEDFEQIKSKR-------AKEYISQLPMKKGIP----WANVLNKEVNPLAIDLLSKM 287
P + +R A I+ +K P A++L+ + + ID L +
Sbjct: 416 LPPKVLISVARRRRLFFDSRDAPRCITNTKGRKRSPGSKSLAHILHCQ-DRYFIDFLQRC 474
Query: 288 LTFNPDKRISAVEALEHPYL 307
L ++P +R++ EA H +L
Sbjct: 475 LEWDPAERMTPDEAAHHEFL 494
>Hs5922004 [R] KOG0667 Dual-specificity tyrosine-phosphorylation regulated
kinase
Length = 601
Score = 134 bits (337), Expect = 2e-31
Identities = 97/335 (28%), Positives = 168/335 (49%), Gaps = 61/335 (18%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTLRELKLLKFFHSHE-- 70
Y+++ ++G+G++G V A + VA+K ++ R F + E+++L+ +
Sbjct: 222 YEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKR--FHRQAAEEIRILEHLRKQDKD 279
Query: 71 NIISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQ---QNLSEDHIQYFVYQILRALK 127
N ++V+ ++ ++ + + EL+ +L ++I + Q S ++ F + IL+ L
Sbjct: 280 NTMNVIHMLENFTFRNH--ICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLD 337
Query: 128 SLHSAQVIHRDLKPSNLLLNSN--CDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRW 185
+LH ++IH DLKP N+LL +KV DFG SS + + Y+ +R+
Sbjct: 338 ALHKNRIIHCDLKPENILLKQQGRSGIKVIDFG------SSCYEHQRVY----TYIQSRF 387
Query: 186 YRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDF 245
YRAPE++L + Y +D+WS GCILAE++ G PL PG+D QL ++E+LG P+ +
Sbjct: 388 YRAPEVILGAR-YGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLL 446
Query: 246 EQIKSKRAKEYISQLPMKKGIP---------------------------------WANVL 272
+ SKRAK ++S KG P W N L
Sbjct: 447 DA--SKRAKNFVSS----KGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNAL 500
Query: 273 NKEVNPLAIDLLSKMLTFNPDKRISAVEALEHPYL 307
+PL +D L + L ++P R++ +AL HP+L
Sbjct: 501 KGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWL 535
>Hs4503427 [R] KOG0667 Dual-specificity tyrosine-phosphorylation regulated
kinase
Length = 528
Score = 134 bits (337), Expect = 2e-31
Identities = 97/335 (28%), Positives = 168/335 (49%), Gaps = 61/335 (18%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTLRELKLLKFFHSHE-- 70
Y+++ ++G+G++G V A + VA+K ++ R F + E+++L+ +
Sbjct: 149 YEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKR--FHRQAAEEIRILEHLRKQDKD 206
Query: 71 NIISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQ---QNLSEDHIQYFVYQILRALK 127
N ++V+ ++ ++ + + EL+ +L ++I + Q S ++ F + IL+ L
Sbjct: 207 NTMNVIHMLENFTFRNH--ICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLD 264
Query: 128 SLHSAQVIHRDLKPSNLLLNSN--CDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRW 185
+LH ++IH DLKP N+LL +KV DFG SS + + Y+ +R+
Sbjct: 265 ALHKNRIIHCDLKPENILLKQQGRSGIKVIDFG------SSCYEHQRVY----TYIQSRF 314
Query: 186 YRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDF 245
YRAPE++L + Y +D+WS GCILAE++ G PL PG+D QL ++E+LG P+ +
Sbjct: 315 YRAPEVILGAR-YGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLL 373
Query: 246 EQIKSKRAKEYISQLPMKKGIP---------------------------------WANVL 272
+ SKRAK ++S KG P W N L
Sbjct: 374 DA--SKRAKNFVSS----KGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNAL 427
Query: 273 NKEVNPLAIDLLSKMLTFNPDKRISAVEALEHPYL 307
+PL +D L + L ++P R++ +AL HP+L
Sbjct: 428 KGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWL 462
>Hs7106269 [DKL] KOG0659 Cdk activating kinase (CAK)/RNA polymerase II
transcription initiation/nucleotide excision repair
factor TFIIH/TFIIK kinase subunit CDK7
Length = 452
Score = 134 bits (336), Expect = 3e-31
Identities = 99/314 (31%), Positives = 159/314 (50%), Gaps = 43/314 (13%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFS-RSMFVTRTLRELKLLKFFHSHEN 71
Y ++ +GEGA+G V A H T +A+KK+ F + LRE+K L+ ++
Sbjct: 4 YCILGRIGEGAHGIVFKAKHVETGEIIALKKVALRRLEDGFPNQALREIKALQEMEDNQY 63
Query: 72 IISVLDIVRPTSWHKFEAVYLVQELMETDLQKIIN--QQNLSEDHIQYFVYQILRALKSL 129
++ L V P L E M +DL +++ Q+ L++ ++ ++ +L+ +
Sbjct: 64 VVQ-LKAVFPHGG----GFVLAFEFMLSDLAEVVRHAQRPLAQAQVKSYLQMLLKGVAFC 118
Query: 130 HSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRAP 189
H+ ++HRDLKP+NLL++++ LK+ DFGLAR + S D SR T VATR
Sbjct: 119 HANNIVHRDLKPANLLISASGQLKIADFGLAR-VFSPDGSR-----LYTHQVATR----- 167
Query: 190 EIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLE---DFE 246
S GCI+ E++ G PLFPGK+ QL +L +LG+P + +
Sbjct: 168 ----------------SVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPELT 211
Query: 247 QIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEHPY 306
++ + Q+PM P VL +V+P A+DLL + L + P +RI+A +AL H Y
Sbjct: 212 ELPDYNKISFKEQVPM----PLEEVL-PDVSPQALDLLGQFLLYPPHQRIAASKALLHQY 266
Query: 307 LATYHDPDDEPDYP 320
T P + P
Sbjct: 267 FFTAPLPAHPSELP 280
>ECU08g1790 [D] KOG0600 Cdc2-related protein kinase
Length = 309
Score = 133 bits (335), Expect = 4e-31
Identities = 82/229 (35%), Positives = 126/229 (54%), Gaps = 17/229 (7%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTLRELKLLKFFHSHENI 72
Y+ + VGEGA+G V + AIKK+ + F +RE+KL K +++I
Sbjct: 4 YENIKQVGEGAFGQVYKSRRTSDGAVFAIKKMPVDRETGFPFTAIREIKLCKSV-INKHI 62
Query: 73 ISVLDIVRPTSWHKFEAVYLVQELMETDLQKII-NQQNLSEDHIQYFVYQILRALKSLHS 131
I + +IV + +++V E M DL ++ + LS D I+ Q++ A+ S+H
Sbjct: 63 IGLDEIVFEEGF-----IFVVLEYMPYDLTGLLASGAKLSTDQIRSITSQLIEAVSSMHG 117
Query: 132 AQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRAPEI 191
++HRD+KPSN+LL+ + LK+ DFGL R ++ G MT V T WYRAPE+
Sbjct: 118 MGLVHRDIKPSNILLDCHGMLKLTDFGLTREIS----------GMMTNRVCTLWYRAPEL 167
Query: 192 MLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSP 240
+L Y+ +D WS GCI+ EM +G+P + G D Q+ +I E LG P
Sbjct: 168 LLGETSYSLKVDAWSVGCIMLEMRLGRPPYRGSDEVSQIKLIFEELGIP 216
>CE18608 [R] KOG0594 Protein kinase PCTAIRE and related kinases
Length = 342
Score = 133 bits (335), Expect = 4e-31
Identities = 93/306 (30%), Positives = 162/306 (52%), Gaps = 30/306 (9%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRT-LRELKLLKFF--HSH 69
+Q+ +G+GAYG V A+K+I S++ + ++ LRE+ ++K +H
Sbjct: 38 FQIHQALGKGAYGNVYRVRSLHDGKDYALKQIMISSKNEGIPQSVLREITVMKHLARKAH 97
Query: 70 ENIISVLDIVRPTSWHKFEAVY------LVQELMETDLQKIINQ--QNLSEDHIQYFVYQ 121
NIIS+ + +H+ + V ++ E + DL + + + E ++ Q
Sbjct: 98 PNIISLKSV-----FHQLDPVRAILKINMIMERCDWDLHTFLRNIPRGVPEQQAKHVTAQ 152
Query: 122 ILRALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYV 181
I+RAL LH+ +IHRDLKP N+LLN + +K+ DFGL++ N F T V
Sbjct: 153 IVRALDFLHTHSIIHRDLKPQNILLNRDQTVKLADFGLSK-------EYSNTTAF-TTLV 204
Query: 182 ATRWYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPT 241
T WYR+PE++L Y + +D+W+ GCI++E+ +PLF G++ QL I + +G+P
Sbjct: 205 VTLWYRSPEVLLQ-SYYNSTVDMWALGCIVSEIYCRQPLFVGQNEAEQLTDIFKKMGTPV 263
Query: 242 LEDFEQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEA 301
+D+ +S A++ Q L+ +++ AI+ + + L ++ KR+SA A
Sbjct: 264 GKDWPS-ESVIARDSFPQYRPTN----LKDLSPQMSKQAIEFVQQCLRYDHSKRLSARGA 318
Query: 302 LEHPYL 307
L HP+L
Sbjct: 319 LSHPFL 324
>CE28918 [R] KOG0594 Protein kinase PCTAIRE and related kinases
Length = 406
Score = 133 bits (334), Expect = 5e-31
Identities = 95/309 (30%), Positives = 162/309 (51%), Gaps = 30/309 (9%)
Query: 10 PSHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRT-LRELKLLKFF-- 66
PS L +G+GAYG V A+K+I S++ + ++ LRE+ ++K
Sbjct: 99 PSLTFLFQALGKGAYGNVYRVRSLHDGKDYALKQIMISSKNEGIPQSVLREITVMKHLAR 158
Query: 67 HSHENIISVLDIVRPTSWHKFEAVY------LVQELMETDLQKIINQ--QNLSEDHIQYF 118
+H NIIS+ + +H+ + V ++ E + DL + + + E ++
Sbjct: 159 KAHPNIISLKSV-----FHQLDPVRAILKINMIMERCDWDLHTFLRNIPRGVPEQQAKHV 213
Query: 119 VYQILRALKSLHSAQVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMT 178
QI+RAL LH+ +IHRDLKP N+LLN + +K+ DFGL++ N F T
Sbjct: 214 TAQIVRALDFLHTHSIIHRDLKPQNILLNRDQTVKLADFGLSK-------EYSNTTAF-T 265
Query: 179 EYVATRWYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLG 238
V T WYR+PE++L Y + +D+W+ GCI++E+ +PLF G++ QL I + +G
Sbjct: 266 TLVVTLWYRSPEVLLQ-SYYNSTVDMWALGCIVSEIYCRQPLFVGQNEAEQLTDIFKKMG 324
Query: 239 SPTLEDFEQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISA 298
+P +D+ +S A++ Q L+ +++ AI+ + + L ++ KR+SA
Sbjct: 325 TPVGKDWPS-ESVIARDSFPQYRPTN----LKDLSPQMSKQAIEFVQQCLRYDHSKRLSA 379
Query: 299 VEALEHPYL 307
AL HP+L
Sbjct: 380 RGALSHPFL 388
>7294866 [K] KOG0666 Cyclin C-dependent kinase CDK8
Length = 531
Score = 133 bits (334), Expect = 5e-31
Identities = 112/364 (30%), Positives = 174/364 (47%), Gaps = 53/364 (14%)
Query: 19 VGEGAYGTVCSAIHKPTNT--KVAIKKIQPFSRSMFVTRTLRELKLLKFFHSHENIISVL 76
VG G YG V A K T+ + A+K+I SM R + L+ LK H+N+I+
Sbjct: 104 VGRGTYGHVYKAKWKETSDGKEYALKQIDGTGLSMSACREIALLRELK----HQNVIT-- 157
Query: 77 DIVRPTSWHKFEAVYLVQELMETDLQKIIN----------QQNLSEDHIQYFVYQILRAL 126
++R H V+L+ + E DL II Q + ++ +YQIL +
Sbjct: 158 -LIRVFLSHNDRKVFLLIDYAEHDLWHIIKFHRAAKATKKQVVVPRGMVKSLLYQILDGI 216
Query: 127 KSLHSAQVIHRDLKPSNLLL----NSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVA 182
LHS V+HRDLKP+N+L+ N +K+ D G AR + + ++ V
Sbjct: 217 HYLHSNWVLHRDLKPANILVMGDGNERGRVKIADMGFARLFNAPLKPLADL----DPVVV 272
Query: 183 TRWYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLF--------PGKDYHH-QLWII 233
T WYRAPE++L + YT A+DIW+ GCI AE++ +P+F YHH QL I
Sbjct: 273 TFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRI 332
Query: 234 LEVLGSPTLEDFEQIKSKRAKEYISQLPMKKGIPWANVLNK-----EVNP--LAIDLLSK 286
V+G P +D+E IK K + + K+ L K ++ P A LL K
Sbjct: 333 FNVMGFPQDKDWEDIK-KMPEHHTLTKDFKRSTYSTCSLAKYMERHKIKPDSKAFHLLQK 391
Query: 287 MLTFNPDKRISAVEALEHPYLATYHDPDDEP------DYPQ---LNLEDNFWKIDNEARD 337
+L +P+KRI++ +A++ Y P + YP+ L +D K DN+ +
Sbjct: 392 LLLMDPNKRITSEQAMQDQYFQEEPQPTQDVFAGCPIPYPKREFLTDDDQEDKSDNKRQQ 451
Query: 338 KNEE 341
+ ++
Sbjct: 452 QQQQ 455
>SPBC8D2.19 [T] KOG0661 MAPK related serine/threonine protein kinase
Length = 559
Score = 132 bits (332), Expect = 8e-31
Identities = 92/307 (29%), Positives = 158/307 (50%), Gaps = 33/307 (10%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTN---TKVAIKKIQPFSRSM--FVTRTLRELKLLKFFH 67
Y + +G+G++GTV A K N VA+KK++ S+ LRE L+
Sbjct: 21 YLVKQKLGDGSFGTVYLAQRKEKNGLYETVAVKKLKNSSKPKPKHELLKLRESLALRKIS 80
Query: 68 SHENIISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQN---LSEDHIQYFVYQILR 124
H +I +L+ T + ++LV E M+ +L ++ ++ +++ + QI+
Sbjct: 81 KHPCLIDLLE----TFMDPYRNIFLVMEFMDCNLFQLFKRRQGRLFTKETAFNILLQIIS 136
Query: 125 ALKSLHSAQVIHRDLKPSNLL--------LNSNCDLKVCDFGLARCLASSDQSRENMVGF 176
++ +H +HRD+KP N+L ++S +K+ DFGLAR SSD
Sbjct: 137 GIEHIHKHGFMHRDIKPENILVKRISPKPISSRYSIKLGDFGLARPSVSSDP-------- 188
Query: 177 MTEYVATRWYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEV 236
+TEYV+TRWYRAPE++L Y ++D+++ GCI+ E+ KPLFPG++ QL + E+
Sbjct: 189 LTEYVSTRWYRAPELLLRSGSYNHSVDLYAFGCIVFEIYSLKPLFPGRNETDQLNRVCEI 248
Query: 237 LGSPTLEDFEQI-----KSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFN 291
LG+P +++ + + + AK LP K P +L + ++ +L +N
Sbjct: 249 LGNPGIDELDTLHYWSQAKELAKRLGFMLPPTKPYPIQKLLPQNCPEGHAKMIPCLLAWN 308
Query: 292 PDKRISA 298
PD R +A
Sbjct: 309 PDVRPTA 315
>CE08727 [G] KOG0658 Glycogen synthase kinase-3
Length = 367
Score = 132 bits (331), Expect = 1e-30
Identities = 86/311 (27%), Positives = 161/311 (51%), Gaps = 24/311 (7%)
Query: 8 DIPSHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTLRELKLLKFFH 67
++ + + L+G G++G V A+ + + +AIKKI+ R F +R L + +
Sbjct: 32 EVEIQFTNLQLIGTGSFGAVYKAVLRENDEPIAIKKIKVDDR--FKSRELTIMHEM---- 85
Query: 68 SHENIISVLD--IVRPTSWHKFEAVYLVQELMETDLQKIINQQNLSEDHIQYFVYQILRA 125
H NII +L +++ + F ++ ++L Q N + + I+ +++Q+LR
Sbjct: 86 DHPNIIRLLYYYVMQQENCLNFVMEFMPKDLAYVHRQFAHNDKQMPAYSIKLYMFQLLRG 145
Query: 126 LKSLHSAQVIHRDLKPSNLLLN-SNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATR 184
+ LH ++HRD+KP NLL++ SN LK+CDFG A+ L ++ + Y+ +R
Sbjct: 146 IGFLHLHNIVHRDIKPKNLLVDESNGILKICDFGSAKRLEKNEPN--------ITYICSR 197
Query: 185 WYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLED 244
+YRAPE++ + Y T++D WS G ++ E++ P+F L + ++ G+P+ ED
Sbjct: 198 YYRAPELIFGSKNYDTSIDTWSVGTVVGELLHNSPIFLADSAVDILALQIKAFGTPSKED 257
Query: 245 FEQIKSKRAKEYISQLPMK--KGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEAL 302
+K EY+ +P G+ + ++++ ++LL+ ++ +P RI EAL
Sbjct: 258 M----AKWNYEYV-HIPYDTITGVGIQKFIGRKLSLSTLELLNSLMKMDPKLRIKPYEAL 312
Query: 303 EHPYLATYHDP 313
PY DP
Sbjct: 313 TLPYFDDLRDP 323
>YOL128c [G] KOG0658 Glycogen synthase kinase-3
Length = 375
Score = 130 bits (326), Expect = 4e-30
Identities = 90/300 (30%), Positives = 149/300 (49%), Gaps = 30/300 (10%)
Query: 19 VGEGAYGTVCSAIHK--------PTNTKVAIKKIQPFSRSMFVTRTLRELKLLK---FFH 67
+G G++GTV +I P K +K + S + + + +R L+ FF
Sbjct: 47 IGHGSFGTVTQSILSSNSIEWLGPYAIKRVVKSPKVQSLELEILQNIRHPNLVTLEFFFE 106
Query: 68 SHENIISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQNLSEDHIQYFVYQILRALK 127
SH + + F Y+ Q L + N + HI+ + +QILRAL
Sbjct: 107 SHCTTKDGGHLYQKN----FVMEYIPQTLSSEIHEYFDNGSKMPTKHIKLYTFQILRALL 162
Query: 128 SLHSAQVIHRDLKPSNLLLNSNCDL-KVCDFGLARCLASSDQSRENMVGFMTEYVATRWY 186
+LHS + H DLKPSN+L+ + + KVCDFG A+ L + + + Y +R+Y
Sbjct: 163 TLHSMSICHGDLKPSNILIIPSSGIAKVCDFGSAQRLDDNTE--------LKTYFCSRFY 214
Query: 187 RAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFE 246
RAPE++L+ ++YTT +DIWS GCI+ EMI G+PLF G + QL I ++LG +
Sbjct: 215 RAPELLLNSKDYTTQIDIWSLGCIIGEMIKGQPLFKGDSANSQLEEIAKLLGRFPKSSIK 274
Query: 247 QIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEHPY 306
S+ ++ ++ KK + W + ++ L K+LT++ +R A + + H +
Sbjct: 275 --NSQELQDSLNDQKFKKFMHWF----PSIEFFDVEFLLKVLTYDATERCDARQLMAHEF 328
>Hs4502745 [K] KOG0666 Cyclin C-dependent kinase CDK8
Length = 464
Score = 129 bits (323), Expect = 9e-30
Identities = 103/321 (32%), Positives = 158/321 (49%), Gaps = 46/321 (14%)
Query: 19 VGEGAYGTVCSAIHKP--TNTKVAIKKIQPFSRSMFVTRTLRELKLLKFFHSHENIISVL 76
VG G YG V A K + A+K+I+ SM R + L+ LK H N+IS+
Sbjct: 27 VGRGTYGHVYKAKRKDGKDDKDYALKQIEGTGISMSACREIALLRELK----HPNVISLQ 82
Query: 77 DIVRPTSWHKFEAVYLVQELMETDLQKIINQQNLSEDH----------IQYFVYQILRAL 126
+ H V+L+ + E DL II S+ + ++ +YQIL +
Sbjct: 83 KVFLS---HADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGI 139
Query: 127 KSLHSAQVIHRDLKPSNLLLNSNCD----LKVCDFGLARCLASSDQSRENMVGFMTEYVA 182
LH+ V+HRDLKP+N+L+ +K+ D G AR S + ++ V
Sbjct: 140 HYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADL----DPVVV 195
Query: 183 TRWYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLF--------PGKDYHH-QLWII 233
T WYRAPE++L + YT A+DIW+ GCI AE++ +P+F YHH QL I
Sbjct: 196 TFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRI 255
Query: 234 LEVLGSPTLEDFEQIKSKRAKEYISQLPMKKGIPWAN------VLNKEVNP--LAIDLLS 285
V+G P +D+E I K+ E+ + + + + N + +V P A LL
Sbjct: 256 FNVMGFPADKDWEDI--KKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQ 313
Query: 286 KMLTFNPDKRISAVEALEHPY 306
K+LT +P KRI++ +A++ PY
Sbjct: 314 KLLTMDPIKRITSEQAMQDPY 334
>Hs17452757 [UT] KOG0662 Cyclin-dependent kinase CDK5
Length = 366
Score = 129 bits (323), Expect = 9e-30
Identities = 99/302 (32%), Positives = 152/302 (49%), Gaps = 34/302 (11%)
Query: 16 VDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFV-TRTLRELKLLKFFHSHENIIS 74
++ +GEG YGTV A + T+ VA+K ++ V + LRE+ LLK H+NI+
Sbjct: 78 LEKIGEGTYGTVFKAKNWETHEIVALKWVRLDDNDDGVPSSALREICLLKEL-KHKNIVR 136
Query: 75 VLDIVRPTSWHKFEAVYLVQELMETDLQKIINQQN--LSEDHIQYFVYQILRALKSLHSA 132
+ D++ H + + LV + L+K + N L + ++ F++Q+L+ L HS
Sbjct: 137 LHDLL-----HSDKKLTLVFKFCHQHLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 191
Query: 133 QVIHRDLKPSNLLLNSNCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRAPEIM 192
V+ RDLKP NLL+N N +LK+ DFGL+R G YV
Sbjct: 192 NVLRRDLKPQNLLINRNGELKLADFGLSRAF-----------GIPICYV----------F 230
Query: 193 LSFQEYTTAMDIWSCGCILAEMI-MGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQIKSK 251
+ Y+T++D+WS GCI AE+ G PLFPG D QL I +LG T E + +
Sbjct: 231 FGAKLYSTSIDLWSAGCIFAELANAGWPLFPGNDVDDQLKRIFWLLGMLTKEQWPSMTKL 290
Query: 252 RAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEHPYLATYH 311
+ P + N++ K ++ DLL +L NP + ISA EAL++PY + +
Sbjct: 291 PDYKLYPLYPATTSL--VNIVPK-LSATGRDLLQNLLKCNPCQCISAEEALQYPYFSDFC 347
Query: 312 DP 313
P
Sbjct: 348 PP 349
>Hs20551615 [K] KOG0666 Cyclin C-dependent kinase CDK8
Length = 358
Score = 127 bits (319), Expect = 3e-29
Identities = 101/321 (31%), Positives = 158/321 (48%), Gaps = 46/321 (14%)
Query: 19 VGEGAYGTVCSAIHKP--TNTKVAIKKIQPFSRSMFVTRTLRELKLLKFFHSHENIISVL 76
VG G YG V A K + A+K+I+ SM R + L+ LK H N+I++
Sbjct: 27 VGRGTYGHVYKARRKDGKDEKEYALKQIEGTGISMSACREIALLRELK----HPNVIALQ 82
Query: 77 DIVRPTSWHKFEAVYLVQELMETDLQKIINQQNLSEDH----------IQYFVYQILRAL 126
+ H V+L+ + E DL II S+ + ++ +YQIL +
Sbjct: 83 KVFLS---HSDRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRSMVKSLLYQILDGI 139
Query: 127 KSLHSAQVIHRDLKPSNLLLNSNCD----LKVCDFGLARCLASSDQSRENMVGFMTEYVA 182
LH+ V+HRDLKP+N+L+ +K+ D G AR S + ++ V
Sbjct: 140 HYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADL----DPVVV 195
Query: 183 TRWYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKD---------YHHQLWII 233
T WYRAPE++L + YT A+DIW+ GCI AE++ +P+F + +H QL I
Sbjct: 196 TFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRI 255
Query: 234 LEVLGSPTLEDFEQIKSKRAKEYISQLPMKKGIPWAN---VLNKEVNPLAID-----LLS 285
V+G P +D+E I ++ EY + + +AN + E + + D LL
Sbjct: 256 FSVMGFPADKDWEDI--RKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQ 313
Query: 286 KMLTFNPDKRISAVEALEHPY 306
K+LT +P KRI++ +AL+ PY
Sbjct: 314 KLLTMDPTKRITSEQALQDPY 334
>CE09532 [G] KOG0658 Glycogen synthase kinase-3
Length = 440
Score = 125 bits (315), Expect = 7e-29
Identities = 88/291 (30%), Positives = 146/291 (49%), Gaps = 26/291 (8%)
Query: 22 GAYGTVCSAI-HKPTNTKVAIKKIQPFSRSM---FVTRTLRELKLLKFFHSHENIISVLD 77
G + V I +P K+AIKK P F+ T RE H+N+I ++
Sbjct: 32 GVFSNVYKGILREPYEKKIAIKKSWPEKGERNFEFIFLTGRERA------KHKNVIHMIF 85
Query: 78 IVRPTSWHKFEAVYLVQELMETDLQKIINQQNLSEDHIQYFVYQILRALKSLHSAQVIHR 137
+ K Y V + M L ++I Q+ L++ I+ + +QI LK L +V+HR
Sbjct: 86 AFSHSYDTKVCESY-VFDFMPNTLAEVIRQK-LTDLDIRLYTWQIFSGLKYLEEHKVVHR 143
Query: 138 DLKPSNLLLNSNCD-LKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYRAPEIMLSFQ 196
DLKP N+L++ + LK+ DFG A+ + + Y TR+YR PE+++
Sbjct: 144 DLKPVNILVDHDTAFLKISDFGSAKIIVKGKANNF--------YQVTRFYRPPELLMKAM 195
Query: 197 EYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQIK-SKRAKE 255
EY + +D+WS GCI+AEM+ +FPG+D HQL + G+P +D +K K KE
Sbjct: 196 EYNSTVDVWSAGCIMAEMVKRHVVFPGRDSAHQLKLYCRCFGAPNEQDISAMKGEKLEKE 255
Query: 256 YISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEHPY 306
Y KG ++N +++P + + ++L + P+KR+ + L+ +
Sbjct: 256 Y---WKFTKGFGLQRLVN-DISPDQLQFIKRILVYAPEKRLRGKQLLQDDF 302
>YNL307c [G] KOG0658 Glycogen synthase kinase-3
Length = 375
Score = 125 bits (314), Expect = 1e-28
Identities = 92/309 (29%), Positives = 150/309 (47%), Gaps = 28/309 (9%)
Query: 19 VGEGAYGTVCSAI----HKPTNTKVAIKKIQPFSRSMFVTRTLRELKLLKFFHSHENIIS 74
+G GA+GTV A K AIKK+ + REL++L+ H NI+
Sbjct: 41 IGRGAFGTVVQAYLTQDKKNWLGPFAIKKVPAHTEYKS-----RELQILRIA-DHPNIVK 94
Query: 75 VLDIVRPTS-----WHKFEAVYLVQELMETDLQKII-NQQNLSEDHIQYFVYQILRALKS 128
+ S ++ A+ + E ++ ++ + + N+ + HI+ + YQI R +
Sbjct: 95 LQYFFTHLSPQDNKVYQHLAMECLPETLQIEINRYVTNKLEMPLKHIRLYTYQIARGMLY 154
Query: 129 LHSAQVIHRDLKPSNLLLNSNCD-LKVCDFGLARCLASSDQSRENMVGFMTEYVATRWYR 187
LH V HRD+KPSN+L++ LK+CDFG A+ L + S Y+ +R+YR
Sbjct: 155 LHGLGVCHRDIKPSNVLVDPETGVLKICDFGSAKKLEHNQPS--------ISYICSRFYR 206
Query: 188 APEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDFEQ 247
APE+++ +YTT +DIW GC++ EM++GK +F G++ QL I ++LG P + F
Sbjct: 207 APELIIGCTQYTTQIDIWGLGCVMGEMLIGKAIFQGQEPLLQLREIAKLLGPPD-KRFIF 265
Query: 248 IKSKRAKEYISQLPMKKGIPWANVLNK--EVNPLAIDLLSKMLTFNPDKRISAVEALEHP 305
+ + P+ G P IDLL K+L + P +R+S L H
Sbjct: 266 FSNPAYDGPLFSKPLFSGSSQQRFEKYFGHSGPDGIDLLMKILVYEPQQRLSPRRILAHQ 325
Query: 306 YLATYHDPD 314
+ + D
Sbjct: 326 FFNELRNDD 334
>CE23751 [R] KOG0667 Dual-specificity tyrosine-phosphorylation regulated
kinase
Length = 796
Score = 125 bits (313), Expect = 1e-28
Identities = 100/338 (29%), Positives = 166/338 (48%), Gaps = 59/338 (17%)
Query: 9 IPSHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTLRELKLLKFFHS 68
I Y+++ ++G+G++G V A VA+K ++ R F + E+++L
Sbjct: 457 IAYRYEVLKVIGKGSFGQVIKAFDHKYQQYVALKLVRNEKR--FHRQADEEIRILDHLRR 514
Query: 69 HE-----NIISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQ---QNLSEDHIQYFVY 120
+ NII +LD + HK + EL+ +L ++I + Q S ++ F Y
Sbjct: 515 QDSDGTHNIIHMLDYFNFRN-HKC----ITFELLSINLYELIKRNKFQGFSLMLVRKFAY 569
Query: 121 QILRALKSLHSAQVIHRDLKPSNLLLNSN--CDLKVCDFGLARCLASSDQSRENMVGFMT 178
+L L L ++IH DLKP N+LL +KV DFG + C D R +
Sbjct: 570 SMLLCLDLLQKNRLIHCDLKPENVLLKQQGRSGIKVIDFG-SSCF---DDQR------IY 619
Query: 179 EYVATRWYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLG 238
Y+ +R+YRAPE++L +Y +D+WS GCILAE++ G PL PG+D + QL +I+E+LG
Sbjct: 620 TYIQSRFYRAPEVILG-TKYGMPIDMWSLGCILAELLTGYPLLPGEDENDQLALIIELLG 678
Query: 239 SPTLEDFEQIKSKRAKEYI-------------------------SQLPMKKGIP----WA 269
P + E +KRA+ +I S+ +G P W+
Sbjct: 679 MPPPKSLET--AKRARTFITSKGYPRYCTATSMPDGSVVLAGARSKRGKMRGPPASRSWS 736
Query: 270 NVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEHPYL 307
L + L +D L + L ++P+ R++ +AL+H +L
Sbjct: 737 TALKNMGDELFVDFLKRCLDWDPETRMTPAQALKHKWL 774
>CE19878 [R] KOG0667 Dual-specificity tyrosine-phosphorylation regulated
kinase
Length = 817
Score = 125 bits (313), Expect = 1e-28
Identities = 100/338 (29%), Positives = 166/338 (48%), Gaps = 59/338 (17%)
Query: 9 IPSHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTLRELKLLKFFHS 68
I Y+++ ++G+G++G V A VA+K ++ R F + E+++L
Sbjct: 457 IAYRYEVLKVIGKGSFGQVIKAFDHKYQQYVALKLVRNEKR--FHRQADEEIRILDHLRR 514
Query: 69 HE-----NIISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQ---QNLSEDHIQYFVY 120
+ NII +LD + HK + EL+ +L ++I + Q S ++ F Y
Sbjct: 515 QDSDGTHNIIHMLDYFNFRN-HKC----ITFELLSINLYELIKRNKFQGFSLMLVRKFAY 569
Query: 121 QILRALKSLHSAQVIHRDLKPSNLLLNSN--CDLKVCDFGLARCLASSDQSRENMVGFMT 178
+L L L ++IH DLKP N+LL +KV DFG + C D R +
Sbjct: 570 SMLLCLDLLQKNRLIHCDLKPENVLLKQQGRSGIKVIDFG-SSCF---DDQR------IY 619
Query: 179 EYVATRWYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLG 238
Y+ +R+YRAPE++L +Y +D+WS GCILAE++ G PL PG+D + QL +I+E+LG
Sbjct: 620 TYIQSRFYRAPEVILG-TKYGMPIDMWSLGCILAELLTGYPLLPGEDENDQLALIIELLG 678
Query: 239 SPTLEDFEQIKSKRAKEYI-------------------------SQLPMKKGIP----WA 269
P + E +KRA+ +I S+ +G P W+
Sbjct: 679 MPPPKSLET--AKRARTFITSKGYPRYCTATSMPDGSVVLAGARSKRGKMRGPPASRSWS 736
Query: 270 NVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEHPYL 307
L + L +D L + L ++P+ R++ +AL+H +L
Sbjct: 737 TALKNMGDELFVDFLKRCLDWDPETRMTPAQALKHKWL 774
>CE05897 [R] KOG0667 Dual-specificity tyrosine-phosphorylation regulated
kinase
Length = 508
Score = 125 bits (313), Expect = 1e-28
Identities = 100/338 (29%), Positives = 166/338 (48%), Gaps = 59/338 (17%)
Query: 9 IPSHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTLRELKLLKFFHS 68
I Y+++ ++G+G++G V A VA+K ++ R F + E+++L
Sbjct: 163 IAYRYEVLKVIGKGSFGQVIKAFDHKYQQYVALKLVRNEKR--FHRQADEEIRILDHLRR 220
Query: 69 HE-----NIISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQ---QNLSEDHIQYFVY 120
+ NII +LD + HK + EL+ +L ++I + Q S ++ F Y
Sbjct: 221 QDSDGTHNIIHMLDYFNFRN-HKC----ITFELLSINLYELIKRNKFQGFSLMLVRKFAY 275
Query: 121 QILRALKSLHSAQVIHRDLKPSNLLLNSN--CDLKVCDFGLARCLASSDQSRENMVGFMT 178
+L L L ++IH DLKP N+LL +KV DFG + C D R +
Sbjct: 276 SMLLCLDLLQKNRLIHCDLKPENVLLKQQGRSGIKVIDFG-SSCF---DDQR------IY 325
Query: 179 EYVATRWYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLG 238
Y+ +R+YRAPE++L +Y +D+WS GCILAE++ G PL PG+D + QL +I+E+LG
Sbjct: 326 TYIQSRFYRAPEVILG-TKYGMPIDMWSLGCILAELLTGYPLLPGEDENDQLALIIELLG 384
Query: 239 SPTLEDFEQIKSKRAKEYI-------------------------SQLPMKKGIP----WA 269
P + E +KRA+ +I S+ +G P W+
Sbjct: 385 MPPPKSLET--AKRARTFITSKGYPRYCTATSMPDGSVVLAGARSKRGKMRGPPASRSWS 442
Query: 270 NVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEHPYL 307
L + L +D L + L ++P+ R++ +AL+H +L
Sbjct: 443 TALKNMGDELFVDFLKRCLDWDPETRMTPAQALKHKWL 480
>At5g35980 [R] KOG0667 Dual-specificity tyrosine-phosphorylation regulated
kinase
Length = 787
Score = 124 bits (312), Expect = 2e-28
Identities = 110/393 (27%), Positives = 186/393 (46%), Gaps = 84/393 (21%)
Query: 8 DIPSHYQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTLRELKLLKFFH 67
D Y + DL+G G +G V TN+ VA+K I+ ++ + + L E+ +L +
Sbjct: 117 DSRQRYIVKDLLGHGTFGQVAKCWVPETNSFVAVKVIK--NQLAYYQQALVEVSILTTLN 174
Query: 68 SHENIISVLDIVRPTSWHKFEA-VYLVQELMETDLQKII--NQ-QNLSEDHIQYFVYQIL 123
+ IVR + ++ + + EL++ +L ++I NQ + LS ++ F QIL
Sbjct: 175 KKYDPEDKNHIVRIYDYFLHQSHLCICFELLDMNLYELIKINQFRGLSLSIVKLFSKQIL 234
Query: 124 RALKSLHSAQVIHRDLKPSNLLLNSNC---DLKVCDFGLARCLASSDQSRENMVGFMTEY 180
L L A +IH DLKP N+LL ++ ++K+ DFG A C+ + Y
Sbjct: 235 LGLALLKDAGIIHCDLKPENILLCASVKPTEIKIIDFGSA-CMEDKT---------VYSY 284
Query: 181 VATRWYRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSP 240
+ +R+YR+PE++L +Q YTTA+D+WS GCI+AE+ +G PLFPG L ++E+LG
Sbjct: 285 IQSRYYRSPEVLLGYQ-YTTAIDMWSFGCIVAELFLGLPLFPGGSEFDILRRMIEILGKQ 343
Query: 241 -----------------------------------------TLEDFEQIKSKR---AKEY 256
T E+FE + K+ KEY
Sbjct: 344 PPDYVLKEAKNTNKFFKCVGSVHNLGNGGTYGGLKSAYMALTGEEFEAREKKKPEIGKEY 403
Query: 257 ---------ISQLPMKKGIPWANVLNK-EVNPLAIDLLSKMLTFNPDKRISAVEALEHPY 306
+ P K +P +V+ + ++ ID L ++ F+P KR S +A +HP+
Sbjct: 404 FNHKNLEEIVKSYPYKINLPEDDVVKETQIRLALIDFLKGLMEFDPAKRWSPFQAAKHPF 463
Query: 307 L------ATYHDPDDEPDYPQLNLEDNFWKIDN 333
+ Y+ P P+ P++++ N K+D+
Sbjct: 464 ITGEPFTCPYNPP---PETPRVHVTQNI-KVDH 492
>Hs5921999 [R] KOG0667 Dual-specificity tyrosine-phosphorylation regulated
kinase
Length = 589
Score = 124 bits (310), Expect = 3e-28
Identities = 96/301 (31%), Positives = 158/301 (51%), Gaps = 28/301 (9%)
Query: 13 YQLVDLVGEGAYGTVCSAIHKPTNTKVAIKKIQPFSRSMFVTRTLRELKLLKFFHSHENI 72
Y++ L+G+G++G V A T VAIK I+ ++ F+ + EL+LL+ + H+
Sbjct: 111 YEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIK--NKKAFLNQAQIELRLLELMNQHDTE 168
Query: 73 ISVLDIVRPTSWHKFEAVYLVQELMETDLQKIINQ---QNLSEDHIQYFVYQILRALKSL 129
+ + + + LV EL+ +L ++ + +S + + Q+ AL L
Sbjct: 169 MKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFL 228
Query: 130 HSAQ--VIHRDLKPSNLLLNS--NCDLKVCDFGLARCLASSDQSRENMVGFMTEYVATRW 185
+ + +IH DLKP N+LL + +K+ DFG SS Q + + +Y+ +R+
Sbjct: 229 ATPELSIIHCDLKPENILLCNPKRSAIKIVDFG------SSCQLGQRIY----QYIQSRF 278
Query: 186 YRAPEIMLSFQEYTTAMDIWSCGCILAEMIMGKPLFPGKDYHHQLWIILEVLGSPTLEDF 245
YR+PE++L Y A+D+WS GCIL EM G+PLF G + Q+ I+EVLG P
Sbjct: 279 YRSPEVLLG-TPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAML 337
Query: 246 EQIKSKRAKEYISQLPMKKGIPWANVLNKEVNPLAIDLLSKMLTFNPDKRISAVEALEHP 305
+Q + +A++Y +LP G W KE L DL+ +ML + P RIS + AL+H
Sbjct: 338 DQ--APKARKYFERLP---GGGWTLRRTKE---LRKDLVLRMLEYEPAARISPLGALQHG 389
Query: 306 Y 306
+
Sbjct: 390 F 390
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.320 0.137 0.412
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,882,912
Number of Sequences: 60738
Number of extensions: 996522
Number of successful extensions: 8070
Number of sequences better than 1.0e-05: 1651
Number of HSP's better than 0.0 without gapping: 497
Number of HSP's successfully gapped in prelim test: 1154
Number of HSP's that attempted gapping in prelim test: 4343
Number of HSP's gapped (non-prelim): 2153
length of query: 362
length of database: 30,389,216
effective HSP length: 108
effective length of query: 254
effective length of database: 23,829,512
effective search space: 6052696048
effective search space used: 6052696048
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)