ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactI0966 good T KOG3689 Signal transduction mechanisms Cyclic nucleotide phosphodiesterase
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactI0966 326530 328077 516
(516 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YOR360c [T] KOG3689 Cyclic nucleotide phosphodiesterase 306 6e-83
Hs9506959 [T] KOG3689 Cyclic nucleotide phosphodiesterase 90 9e-18
CE23151 [T] KOG1229 3'5'-cyclic nucleotide phosphodiesterases 89 2e-17
Hs22051993 [T] KOG1229 3'5'-cyclic nucleotide phosphodiesterases 88 4e-17
Hs4505675 [T] KOG3689 Cyclic nucleotide phosphodiesterase 84 5e-16
Hs20538967 [T] KOG3689 Cyclic nucleotide phosphodiesterase 81 3e-15
Hs4505665 [T] KOG3689 Cyclic nucleotide phosphodiesterase 80 7e-15
7298454 [T] KOG3689 Cyclic nucleotide phosphodiesterase 80 7e-15
Hs4505669 [T] KOG3689 Cyclic nucleotide phosphodiesterase 79 2e-14
Hs15812212 [T] KOG3689 Cyclic nucleotide phosphodiesterase 78 3e-14
Hs5453864 [T] KOG3689 Cyclic nucleotide phosphodiesterase 78 4e-14
Hs4505667 [T] KOG3689 Cyclic nucleotide phosphodiesterase 78 4e-14
Hs22050327 [T] KOG3689 Cyclic nucleotide phosphodiesterase 78 4e-14
Hs15812216 [T] KOG3689 Cyclic nucleotide phosphodiesterase 78 4e-14
Hs15812214 [T] KOG3689 Cyclic nucleotide phosphodiesterase 78 4e-14
7297876 [T] KOG3688 Cyclic GMP phosphodiesterase 78 4e-14
7291615 [T] KOG1229 3'5'-cyclic nucleotide phosphodiesterases 77 6e-14
Hs5453862 [T] KOG3689 Cyclic nucleotide phosphodiesterase 76 1e-13
7290408 [T] KOG3689 Cyclic nucleotide phosphodiesterase 75 3e-13
Hs4505677 [T] KOG3688 Cyclic GMP phosphodiesterase 74 4e-13
Hs4505663 [T] KOG3689 Cyclic nucleotide phosphodiesterase 74 5e-13
CE28641 [T] KOG3689 Cyclic nucleotide phosphodiesterase 74 7e-13
CE02038 [T] KOG3689 Cyclic nucleotide phosphodiesterase 74 7e-13
Hs19923440 [T] KOG3689 Cyclic nucleotide phosphodiesterase 72 2e-12
Hs4585864 [T] KOG3689 Cyclic nucleotide phosphodiesterase 72 3e-12
Hs4826894 [T] KOG3688 Cyclic GMP phosphodiesterase 69 1e-11
HsM4826892 [T] KOG3688 Cyclic GMP phosphodiesterase 67 6e-11
Hs21361262 [T] KOG3688 Cyclic GMP phosphodiesterase 67 6e-11
HsM5453866 [T] KOG3689 Cyclic nucleotide phosphodiesterase 65 2e-10
Hs21361308 [T] KOG3689 Cyclic nucleotide phosphodiesterase 64 7e-10
CE16340 [T] KOG3688 Cyclic GMP phosphodiesterase 63 9e-10
Hs4505657 [T] KOG3689 Cyclic nucleotide phosphodiesterase 60 1e-08
CE24876 [T] KOG3688 Cyclic GMP phosphodiesterase 52 3e-06
>YOR360c [T] KOG3689 Cyclic nucleotide phosphodiesterase
Length = 526
Score = 306 bits (783), Expect = 6e-83
Identities = 182/487 (37%), Positives = 273/487 (55%), Gaps = 45/487 (9%)
Query: 52 FEGSCLFICYDPIRTKLRSTSVLNSMDPETLSCFISDMFPCFNVMCVPSANFIDYYESVI 111
FE + YDP + +L L FP FN+ + E +
Sbjct: 55 FETGVSIVLYDPSKFQL---------SVRQLDVLFKRFFPSFNISAIDHTR-----EENL 100
Query: 112 LNTDMIGNDDSDEDMDRISSVYRWMYSGSESLTDGSEEH-------HDLP---CSNNLYT 161
+ + ++S +RI+ + WMY + DG ++ + +P C N+YT
Sbjct: 101 QRLECVERENSI-CRNRITRINHWMYHHHDDTPDGINKNSYGTVNGNSVPTQACEANIYT 159
Query: 162 MASHLAYVNSNDRLKRERVPIW----DYIDITDMIKSNLSHNDAYYWKCLDSWDFCAHSL 217
+ HL + L++ VP +++ +S ++YW L +WDFCA SL
Sbjct: 160 LLLHLNDSKAQ-HLRKASVPRLIRNIEFMSFLSDPIEKISQEGSHYWNILSTWDFCALSL 218
Query: 218 NCTELIWCAYLLFHKLNTESNLSHAPPSTNRLLLMLLNIEAAYHQGNKFHNFRHAVDVLQ 277
+ ELIWC + L KL+ ++ + A N+LLL+L +E++YHQ NKFHNFRHA+DV+Q
Sbjct: 219 STQELIWCGFTLIKKLSKDAKVLIAD---NKLLLLLFTLESSYHQVNKFHNFRHAIDVMQ 275
Query: 278 ATYQLC-HLLELPKLASFLLCIAAIGHDVAHPGTNNMLFNKYVSPISKYYKEQSVLENFH 336
AT++LC +LL+ + + LLC+AAIGHDV HPGTNN L S +++ +K S+LENFH
Sbjct: 276 ATWRLCTYLLKDNPVQTLLLCMAAIGHDVGHPGTNNQLLCNCESEVAQNFKNVSILENFH 335
Query: 337 ADIYLDILSHYWPEL----SQEFTGIKDSIIATDMALHNHYVETIKQETGPNLTGLTSLI 392
+++ +LS +WP+L ++F I ++I+ATDMALH+ Y + + E L SLI
Sbjct: 336 RELFQQLLSEHWPQLLSISKKKFDFISEAILATDMALHSQYEDRLMHENPMKQITLISLI 395
Query: 393 IKAADISNVTRPLLISAKWAALISMEFKECAVLE---KNLVELADAKDDEKKRISYKLDL 449
IKAADISNVTR L ISA+WA LI++EF +CA+LE K D D K + +
Sbjct: 396 IKAADISNVTRTLSISARWAYLITLEFNDCALLETFHKAHRPEQDCFGDSYKNVDSPKE- 454
Query: 450 DFDSYSELPSNI---DDILKEFPNIPKGQAFFIDTFALSLFSGLGLKYKQLQFLVDNVEN 506
D +S + N+ DDI+K+ P+IP GQ FFI+TFA F+ L K+ L+FL DNV+
Sbjct: 455 DLESIQNILVNVTDPDDIIKDHPHIPNGQIFFINTFAEVFFNALSQKFSGLKFLSDNVKI 514
Query: 507 NRKFWME 513
N+++WM+
Sbjct: 515 NKEYWMK 521
>Hs9506959 [T] KOG3689 Cyclic nucleotide phosphodiesterase
Length = 450
Score = 89.7 bits (221), Expect = 9e-18
Identities = 75/251 (29%), Positives = 114/251 (44%), Gaps = 28/251 (11%)
Query: 228 LLFHKLNTESNLSHAPPSTNRLLLMLLNIEAAYHQGNKFHNFRHAVDVLQATYQLCHLLE 287
LL H NT + H L L+ ++ YH N +HN HA DV QA + C+L E
Sbjct: 134 LLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYHNAVHAADVTQAMH--CYLKE 191
Query: 288 LPKLASFLL-------CIAAIGHDVAHPGTNNMLFNKYVSPISKYYKEQSVLENFHADIY 340
PKLASFL +AA HDV HPG N K ++ Y+ SVLEN H
Sbjct: 192 -PKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLANLYQNMSVLENHHWRST 250
Query: 341 LD------ILSHYWPELSQEF-TGIKDSIIATDMALHNHYVETIKQ---------ETGPN 384
+ +L+H E++Q+ + I+ATD+ N ++ +K E +
Sbjct: 251 IGMLRESRLLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTRLKAHLHNKDLRLEDAQD 310
Query: 385 LTGLTSLIIKAADISNVTRPLLISAKWAALISMEFKECAVLEKNL-VELADAKDDEKKRI 443
+ + +K ADI N R +S +W+ + EF LE+ +E++ + +K I
Sbjct: 311 RHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGELEQKFELEISPLCNQQKDSI 370
Query: 444 SYKLDLDFDSY 454
+ + F SY
Sbjct: 371 P-SIQIGFMSY 380
>CE23151 [T] KOG1229 3'5'-cyclic nucleotide phosphodiesterases
Length = 760
Score = 88.6 bits (218), Expect = 2e-17
Identities = 77/286 (26%), Positives = 127/286 (43%), Gaps = 57/286 (19%)
Query: 253 LLNIEAAYHQGNKFHNFRHAVDVLQATYQLCHLLELPKLA-------SFLLCIAAIGHDV 305
+L+IEA YH GN +HN HA DVLQAT L+ P +A + +AA HD+
Sbjct: 488 ILSIEAHYHAGNTYHNATHAADVLQAT---SFFLDSPSVAVHVNESHAVAALLAAAVHDL 544
Query: 306 AHPGTNNMLFNKYVSPISKYYKEQSVLENFHADIYLDI-LSH-----YWPELS-QEFTGI 358
HPG N ++ Y + S+LEN H + + L H + LS +EF +
Sbjct: 545 DHPGRGNAYLINTRQSLAILYNDNSILENHHIALAFQLTLQHNANVNIFSSLSREEFIQM 604
Query: 359 K----DSIIATDMALH---------NHYVETIKQETGPNLTGLTSLIIKAADISNVTRPL 405
+ + ++ATD++ H H + +++ N + +++K ADISN R
Sbjct: 605 RHAMVEMVLATDISRHFEYLAKFNKMHVTDVPEEQRDTNSLTICDMLVKCADISNPAREW 664
Query: 406 LISAKWAALISMEFKECAVLEKNLVELADAKDDEKKRISYKLDLDFDSYSELPSNIDDIL 465
+ +WA I E+ E +++++K LP ++
Sbjct: 665 GLCQRWAHRIVEEYFE------------QTREEKEK--------------GLPVTMEVFD 698
Query: 466 KEFPNIPKGQAFFIDTFALSLFSGLGLKYKQLQFLVDNVENNRKFW 511
+ N+P Q FID FA F+ ++ +L L D +E+N + W
Sbjct: 699 RNTCNVPITQCGFIDMFAREAFATF-TEFAKLGELSDQLESNYEKW 743
>Hs22051993 [T] KOG1229 3'5'-cyclic nucleotide phosphodiesterases
Length = 761
Score = 87.8 bits (216), Expect = 4e-17
Identities = 92/352 (26%), Positives = 137/352 (38%), Gaps = 76/352 (21%)
Query: 208 DSWDFCAHSLNCTE----LIWCAYLLFHKLNTESNLSHAPPSTNRLLLMLLNIEAAYHQG 263
+SWDF L L++ +F + L+ S L IEA YH
Sbjct: 431 ESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNC---SETTLRAWFQVIEANYHSS 487
Query: 264 NKFHNFRHAVDVLQATYQLCHLL----ELPKLASFLLCIAAIGHDVAHPGTNNMLFNKYV 319
N +HN HA DVL AT L +L IAA HDV HPG N
Sbjct: 488 NAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSFLCNAG 547
Query: 320 SPISKYYKEQSVLENFH-------------ADIYLDILSHYWPELSQEFTGIKDSIIATD 366
S ++ Y + +VLE+ H +I+ +I +++ L Q I D ++AT+
Sbjct: 548 SELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQ---AIIDMVLATE 604
Query: 367 MALH----NHYVETIKQETGPNLTG------------------LTSLIIKAADISNVTRP 404
M H N +V +I + + G + ++IK AD++N RP
Sbjct: 605 MTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVANPCRP 664
Query: 405 LLISAKWAALISMEFKECAVLEKNLVELADAKDDEKKRISYKLDLDFDSYSELPSNIDDI 464
L + +WA IS E+ A+ DE+KR LP +
Sbjct: 665 LDLCIEWAGRISEEY--------------FAQTDEEKR------------QGLPVVMPVF 698
Query: 465 LKEFPNIPKGQAFFIDTFALSLFSGLGLKYKQLQFLVDNVENNRKFWMERGD 516
+ +IPK Q FID F +F + L L+ ++ +N K W D
Sbjct: 699 DRNTCSIPKSQISFIDYFITDMFDAWD-AFAHLPALMQHLADNYKHWKTLDD 749
>Hs4505675 [T] KOG3689 Cyclic nucleotide phosphodiesterase
Length = 593
Score = 84.0 bits (206), Expect = 5e-16
Identities = 64/221 (28%), Positives = 100/221 (44%), Gaps = 28/221 (12%)
Query: 221 ELIWCAYLLFHKLNTESNLSHAPPSTNRLLLMLLNIEAAYHQGNKFHNFRHAVDVLQATY 280
E++ C ++H L + S P + R L + + ++ N FHNFRH V Q Y
Sbjct: 270 EMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHD----NYRNNPFHNFRHCFCVAQMMY 325
Query: 281 QLCHLLELPKLAS----FLLCIAAIGHDVAHPGTNNMLFNKYVSPISKYYKEQSVLENFH 336
+ L L + S +L AAI HD+ HPG NN + ++ Y + S LEN H
Sbjct: 326 SMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHH 385
Query: 337 ADIYLDILSHYWPE-----------LSQEFTGIKDSIIATDMALHNHYVETIKQE----- 380
+ IL+ PE Q G+ I+ATDMA H +++ K++
Sbjct: 386 CAVAFQILAE--PECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFD 443
Query: 381 --TGPNLTGLTSLIIKAADISNVTRPLLISAKWAALISMEF 419
++T L ++IK DISN RP+ ++ W + E+
Sbjct: 444 YSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEY 484
>Hs20538967 [T] KOG3689 Cyclic nucleotide phosphodiesterase
Length = 418
Score = 81.3 bits (199), Expect = 3e-15
Identities = 69/223 (30%), Positives = 100/223 (43%), Gaps = 26/223 (11%)
Query: 228 LLFHKLNTESNLSHAPPSTNRLLLMLLNIEAAYHQGNKFHNFRHAVDVLQATYQLCHLLE 287
L FH + + + +L L+ I+ YH N +HN HA DV QA + C+L E
Sbjct: 109 LTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMH--CYLKE 166
Query: 288 LPKLAS-------FLLCIAAIGHDVAHPGTNNMLFNKYVSPISKYYKEQSVLENFHADIY 340
PKLA+ L IAA HD+ HPG N K ++ YK SVLEN H
Sbjct: 167 -PKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSA 225
Query: 341 LDIL------SHYWPELSQEF-TGIKDSIIATDMALHNHYVETIKQ---------ETGPN 384
+ +L SH E Q+ T I I+ATD++ N Y+ + E +
Sbjct: 226 VGLLRESGLFSHLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDRGDLCLEDTRH 285
Query: 385 LTGLTSLIIKAADISNVTRPLLISAKWAALISMEFKECAVLEK 427
+ + +K ADI N R +S +W+ ++ EF +EK
Sbjct: 286 RHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFHQGDIEK 328
>Hs4505665 [T] KOG3689 Cyclic nucleotide phosphodiesterase
Length = 712
Score = 80.1 bits (196), Expect = 7e-15
Identities = 77/297 (25%), Positives = 123/297 (40%), Gaps = 60/297 (20%)
Query: 249 LLLMLLNIEAAYHQGNKFHNFRHAVDVLQATYQLCHLLELPKLASFLLCIAAIG----HD 304
L LL +E YH +HN HA DV Q+T+ L L + + L +AA+ HD
Sbjct: 370 LATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHD 429
Query: 305 VAHPGTNNMLFNKYVSPISKYYKEQSVLENFHADIYLDILSHYWPELSQEFTG------- 357
V HPG +N S ++ Y + SVLEN H + +L ++ Q +
Sbjct: 430 VDHPGVSNQFLINTNSDVALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLR 489
Query: 358 --IKDSIIATDMALHNHYVETIKQETGPNLTGLTSL-----------------IIKAADI 398
+ D ++ATDM+ H + + +K T +TSL ++ AD+
Sbjct: 490 RMVIDMVLATDMSKHMNLLADLK--TMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADL 547
Query: 399 SNVTRPLLISAKWAALISMEFKECAVLEKNLVELADAKDDEKKRISYKLDLDFDSYSELP 458
SN T+PL + +W I EF + D + + IS D
Sbjct: 548 SNPTKPLPLYRQWTDRIMAEF----------FQQGDRERESGLDISPMCD---------- 587
Query: 459 SNIDDILKEFPNIPKGQAFFIDTFALSLF-SGLGLKYKQLQFLVDNVENNRKFWMER 514
K ++ K Q FID A L+ + L + Q L+D +E+NR+++ +
Sbjct: 588 -------KHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSK 637
>7298454 [T] KOG3689 Cyclic nucleotide phosphodiesterase
Length = 1284
Score = 80.1 bits (196), Expect = 7e-15
Identities = 72/286 (25%), Positives = 130/286 (45%), Gaps = 49/286 (17%)
Query: 253 LLNIEAAYHQGNKFHNFRHAVDVLQATYQLCHLLELPKLASFLLCIAAI----GHDVAHP 308
LL+++ Y +HN+RHA +V Q + + + K+ + C+A I HD+ H
Sbjct: 680 LLSVKKNYRNVT-YHNWRHAFNVAQMMFAILTTTQWWKIFGEIECLALIIGCLCHDLDHR 738
Query: 309 GTNNMLFNKYVSPISKYYKEQSVLENFHADIYLDILSHYWPELSQEFTG---------IK 359
GTNN K SP+++ Y S +E+ H D L IL+ ++ + ++
Sbjct: 739 GTNNSFQIKASSPLAQLYST-STMEHHHFDQCLMILNSPGNQILANLSSDDYCRVIRVLE 797
Query: 360 DSIIATDMALH----NHYVETIKQETGPNLTGLTSLIIKA-----ADISNVTRPLLISAK 410
D+I++TD+A++ ++E++ Q T + +++A D+S +T+P I +
Sbjct: 798 DAILSTDLAVYFKKRGPFLESVSQPTSYWVAEEPRALLRAMSMTVCDLSAITKPWEIEKR 857
Query: 411 WAALISMEFKECAVLEKNLVELADAKDDEKKRISYKLDLDFDSYSELPSNIDDILKEFPN 470
A L+S EF E +EK + + P +I + KE
Sbjct: 858 VADLVSSEFFEQGDMEKQELNIT------------------------PIDIMNREKE-DE 892
Query: 471 IPKGQAFFIDTFALSLFSGLGLKYKQLQFLVDNVENNRKFWMERGD 516
+P Q FID+ L ++ +L+ LV+ V +NR W++ D
Sbjct: 893 LPMMQVNFIDSICLPIYEAFATLSDKLEPLVEGVRDNRGHWIDLAD 938
>Hs4505669 [T] KOG3689 Cyclic nucleotide phosphodiesterase
Length = 854
Score = 79.0 bits (193), Expect = 2e-14
Identities = 82/344 (23%), Positives = 143/344 (40%), Gaps = 66/344 (19%)
Query: 208 DSWDFCAHSLNCTEL--IWCAYLLFHKLNTESNLSHAPPSTNRLLLMLLNIEAAYHQGNK 265
D ++F L CTEL + C ++++L P L+ L +I Y +
Sbjct: 500 DIYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQ-IPQEV--LVRFLFSISKGYRRIT- 555
Query: 266 FHNFRHAVDVLQATYQLCHLLELPK----LASFLLCIAAIGHDVAHPGTNNMLFNKYVSP 321
+HN+RH +V Q + L +L L +F + A + HD+ H GTNN+ K +P
Sbjct: 556 YHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNP 615
Query: 322 ISKYYKEQSVLENFHADIYLDILSHYWPELSQEFTG---------IKDSIIATDMALH-- 370
++K + S+LE H + +LS + Q + +IIATD+AL+
Sbjct: 616 LAKLH-GSSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFK 674
Query: 371 ------------------NHYVETIKQETGPNLTGLTSLIIKAADISNVTRPLLISAKWA 412
+VE + ET + ++++ A D+S +T+P + +K A
Sbjct: 675 KRAMFQKIVDESKNYQDKKSWVEYLSLET-TRKEIVMAMMMTACDLSAITKPWEVQSKVA 733
Query: 413 ALISMEFKECAVLEKNLVELADAKDDEKKRISYKLDLDFDSYSELPSNIDDILKEFPNIP 472
L++ EF E LE+ +++ +P + E P +
Sbjct: 734 LLVAAEFWEQGDLERTVLD----------------------QQPIPMMDRNKAAELPKLQ 771
Query: 473 KGQAFFIDTFALSLFSGLGLKYKQLQFLVDNVENNRKFWMERGD 516
G F+ TF FS ++++ + D ++NNRK W D
Sbjct: 772 VGFIDFVCTFVYKEFSRF---HEEILPMFDRLQNNRKEWKALAD 812
>Hs15812212 [T] KOG3689 Cyclic nucleotide phosphodiesterase
Length = 833
Score = 78.2 bits (191), Expect = 3e-14
Identities = 81/327 (24%), Positives = 136/327 (40%), Gaps = 51/327 (15%)
Query: 207 LDSWDFCAHSLNCTELIWCAYLLFHKLNTESNLSHAPPSTNRLLLMLLNIEAAYHQGNKF 266
+ + F L+ E C +F LN N L +L+++ Y + +
Sbjct: 514 ITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQM---KHEVLCRWILSVKKNYRKNVAY 570
Query: 267 HNFRHAVDVLQATYQLCHL----LELPKLASFLLCIAAIGHDVAHPGTNNMLFNKYVSPI 322
HN+RHA + Q + +L L L IAA+ HD+ H G NN + P+
Sbjct: 571 HNWRHAFNTAQCMFAALKAGKIQNKLTDLGILALLIAALSHDLDHRGVNNSYIQRSEHPL 630
Query: 323 SKYYKEQSVLENFHADIYLDILSH---------YWPELSQEFTGIKDSIIATDMALH--- 370
++ Y S++E+ H D L IL+ E IK +I+ATD+AL+
Sbjct: 631 AQLYC-HSIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKR 689
Query: 371 -NHYVETIKQE----TGPNLTGL-TSLIIKAADISNVTRPLLISAKWAALISMEFKECAV 424
+ E I++ P+ L ++++ A D+S +T+P I + A L++ EF
Sbjct: 690 RGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEF----- 744
Query: 425 LEKNLVELADAKDDEKKRISYKLDLDFDSYSELPSNIDDILKEFPNIPKGQAFFIDTFAL 484
D D E+K ++ + P+++ + K+ IP Q FID L
Sbjct: 745 --------FDQGDRERKELNIE-----------PTDLMNREKK-NKIPSMQVGFIDAICL 784
Query: 485 SLFSGLGLKYKQLQFLVDNVENNRKFW 511
L+ L + L+D NR+ W
Sbjct: 785 QLYEALTHVSEDCFPLLDGCRKNRQKW 811
>Hs5453864 [T] KOG3689 Cyclic nucleotide phosphodiesterase
Length = 809
Score = 77.8 bits (190), Expect = 4e-14
Identities = 74/292 (25%), Positives = 123/292 (41%), Gaps = 56/292 (19%)
Query: 249 LLLMLLNIEAAYHQGNKFHNFRHAVDVLQATYQLCHLLELPKLASFLLCIAAIG----HD 304
L+ L+ +E YH +HN HA DV+Q+T+ L L + + L +AAI HD
Sbjct: 444 LITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHD 503
Query: 305 VAHPGTNNMLFNKYVSPISKYYKEQSVLENFHADIYLDILSHYWPELSQEFTG------- 357
V HPG +N S ++ Y + SVLEN H + +L ++ Q T
Sbjct: 504 VDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLR 563
Query: 358 --IKDSIIATDMALHNHY---VETIKQETGPNLTGLTSL------------IIKAADISN 400
+ D ++ATDM+ H + ++T+ + +G+ L ++ AD+SN
Sbjct: 564 KMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSN 623
Query: 401 VTRPLLISAKWAALISMEFKECAVLEKNLVELADAKDDEKKRISYKLDLDFDSYSELPSN 460
T+PL + +W I EF D + + IS D
Sbjct: 624 PTKPLQLYRQWTDRIMEEF----------FRQGDRERERGMEISPMCD------------ 661
Query: 461 IDDILKEFPNIPKGQAFFIDTFALSLF-SGLGLKYKQLQFLVDNVENNRKFW 511
K ++ K Q FID L+ + L + Q ++D +E+NR+++
Sbjct: 662 -----KHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWY 708
>Hs4505667 [T] KOG3689 Cyclic nucleotide phosphodiesterase
Length = 875
Score = 77.8 bits (190), Expect = 4e-14
Identities = 81/327 (24%), Positives = 136/327 (40%), Gaps = 51/327 (15%)
Query: 207 LDSWDFCAHSLNCTELIWCAYLLFHKLNTESNLSHAPPSTNRLLLMLLNIEAAYHQGNKF 266
+ + F L+ E C +F LN N L +L+++ Y + +
Sbjct: 556 ITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQM---KHEVLCRWILSVKKNYRKNVAY 612
Query: 267 HNFRHAVDVLQATYQLCHL----LELPKLASFLLCIAAIGHDVAHPGTNNMLFNKYVSPI 322
HN+RHA + Q + +L L L IAA+ HD+ H G NN + P+
Sbjct: 613 HNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPL 672
Query: 323 SKYYKEQSVLENFHADIYLDILSH---------YWPELSQEFTGIKDSIIATDMALH--- 370
++ Y S++E+ H D L IL+ E IK +I+ATD+AL+
Sbjct: 673 AQLYC-HSIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKR 731
Query: 371 -NHYVETIKQE----TGPNLTGL-TSLIIKAADISNVTRPLLISAKWAALISMEFKECAV 424
+ E I++ P+ L ++++ A D+S +T+P I + A L++ EF
Sbjct: 732 RGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEF----- 786
Query: 425 LEKNLVELADAKDDEKKRISYKLDLDFDSYSELPSNIDDILKEFPNIPKGQAFFIDTFAL 484
D D E+K ++ + P+++ + K+ IP Q FID L
Sbjct: 787 --------FDQGDRERKELNIE-----------PTDLMNREKK-NKIPSMQVGFIDAICL 826
Query: 485 SLFSGLGLKYKQLQFLVDNVENNRKFW 511
L+ L + L+D NR+ W
Sbjct: 827 QLYEALTHVSEDCFPLLDGCRKNRQKW 853
>Hs22050327 [T] KOG3689 Cyclic nucleotide phosphodiesterase
Length = 641
Score = 77.8 bits (190), Expect = 4e-14
Identities = 74/292 (25%), Positives = 123/292 (41%), Gaps = 56/292 (19%)
Query: 249 LLLMLLNIEAAYHQGNKFHNFRHAVDVLQATYQLCHLLELPKLASFLLCIAAIG----HD 304
L+ L+ +E YH +HN HA DV+Q+T+ L L + + L +AAI HD
Sbjct: 276 LITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHD 335
Query: 305 VAHPGTNNMLFNKYVSPISKYYKEQSVLENFHADIYLDILSHYWPELSQEFTG------- 357
V HPG +N S ++ Y + SVLEN H + +L ++ Q T
Sbjct: 336 VDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLR 395
Query: 358 --IKDSIIATDMALHNHY---VETIKQETGPNLTGLTSL------------IIKAADISN 400
+ D ++ATDM+ H + ++T+ + +G+ L ++ AD+SN
Sbjct: 396 KMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSN 455
Query: 401 VTRPLLISAKWAALISMEFKECAVLEKNLVELADAKDDEKKRISYKLDLDFDSYSELPSN 460
T+PL + +W I EF D + + IS D
Sbjct: 456 PTKPLQLYRQWTDRIMEEF----------FRQGDRERERGMEISPMCD------------ 493
Query: 461 IDDILKEFPNIPKGQAFFIDTFALSLF-SGLGLKYKQLQFLVDNVENNRKFW 511
K ++ K Q FID L+ + L + Q ++D +E+NR+++
Sbjct: 494 -----KHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWY 540
>Hs15812216 [T] KOG3689 Cyclic nucleotide phosphodiesterase
Length = 823
Score = 77.8 bits (190), Expect = 4e-14
Identities = 81/327 (24%), Positives = 136/327 (40%), Gaps = 51/327 (15%)
Query: 207 LDSWDFCAHSLNCTELIWCAYLLFHKLNTESNLSHAPPSTNRLLLMLLNIEAAYHQGNKF 266
+ + F L+ E C +F LN N L +L+++ Y + +
Sbjct: 504 ITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQM---KHEVLCRWILSVKKNYRKNVAY 560
Query: 267 HNFRHAVDVLQATYQLCHL----LELPKLASFLLCIAAIGHDVAHPGTNNMLFNKYVSPI 322
HN+RHA + Q + +L L L IAA+ HD+ H G NN + P+
Sbjct: 561 HNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPL 620
Query: 323 SKYYKEQSVLENFHADIYLDILSH---------YWPELSQEFTGIKDSIIATDMALH--- 370
++ Y S++E+ H D L IL+ E IK +I+ATD+AL+
Sbjct: 621 AQLYC-HSIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKR 679
Query: 371 -NHYVETIKQE----TGPNLTGL-TSLIIKAADISNVTRPLLISAKWAALISMEFKECAV 424
+ E I++ P+ L ++++ A D+S +T+P I + A L++ EF
Sbjct: 680 RGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEF----- 734
Query: 425 LEKNLVELADAKDDEKKRISYKLDLDFDSYSELPSNIDDILKEFPNIPKGQAFFIDTFAL 484
D D E+K ++ + P+++ + K+ IP Q FID L
Sbjct: 735 --------FDQGDRERKELNIE-----------PTDLMNREKK-NKIPSMQVGFIDAICL 774
Query: 485 SLFSGLGLKYKQLQFLVDNVENNRKFW 511
L+ L + L+D NR+ W
Sbjct: 775 QLYEALTHVSEDCFPLLDGCRKNRQKW 801
>Hs15812214 [T] KOG3689 Cyclic nucleotide phosphodiesterase
Length = 865
Score = 77.8 bits (190), Expect = 4e-14
Identities = 81/327 (24%), Positives = 136/327 (40%), Gaps = 51/327 (15%)
Query: 207 LDSWDFCAHSLNCTELIWCAYLLFHKLNTESNLSHAPPSTNRLLLMLLNIEAAYHQGNKF 266
+ + F L+ E C +F LN N L +L+++ Y + +
Sbjct: 546 ITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQM---KHEVLCRWILSVKKNYRKNVAY 602
Query: 267 HNFRHAVDVLQATYQLCHL----LELPKLASFLLCIAAIGHDVAHPGTNNMLFNKYVSPI 322
HN+RHA + Q + +L L L IAA+ HD+ H G NN + P+
Sbjct: 603 HNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPL 662
Query: 323 SKYYKEQSVLENFHADIYLDILSH---------YWPELSQEFTGIKDSIIATDMALH--- 370
++ Y S++E+ H D L IL+ E IK +I+ATD+AL+
Sbjct: 663 AQLYC-HSIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKR 721
Query: 371 -NHYVETIKQE----TGPNLTGL-TSLIIKAADISNVTRPLLISAKWAALISMEFKECAV 424
+ E I++ P+ L ++++ A D+S +T+P I + A L++ EF
Sbjct: 722 RGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEF----- 776
Query: 425 LEKNLVELADAKDDEKKRISYKLDLDFDSYSELPSNIDDILKEFPNIPKGQAFFIDTFAL 484
D D E+K ++ + P+++ + K+ IP Q FID L
Sbjct: 777 --------FDQGDRERKELNIE-----------PTDLMNREKK-NKIPSMQVGFIDAICL 816
Query: 485 SLFSGLGLKYKQLQFLVDNVENNRKFW 511
L+ L + L+D NR+ W
Sbjct: 817 QLYEALTHVSEDCFPLLDGCRKNRQKW 843
>7297876 [T] KOG3688 Cyclic GMP phosphodiesterase
Length = 605
Score = 77.8 bits (190), Expect = 4e-14
Identities = 75/249 (30%), Positives = 111/249 (44%), Gaps = 28/249 (11%)
Query: 205 KCLDSWDFCAHSLNCTE----LIWCAYLLFHKLNTESNLSHAPPSTNRLLLMLLNIEAAY 260
K LD W F +L + + AY LF++ + AP L L +E Y
Sbjct: 176 KNLDDWTFDVFALTEAASGQVVKYVAYELFNRYGSIHKFKIAP---GILEAFLHRVEEGY 232
Query: 261 -HQGNKFHNFRHAVDVLQAT-YQLCH---LLELPKLASFLLCIAAIGHDVAHPGTNNMLF 315
N +HN HAVDV+Q Y LC+ + L L F +AA+ HD H GT N
Sbjct: 233 CRYRNPYHNNLHAVDVMQTIHYCLCNTGLMNWLTDLEIFASLLAALLHDYEHTGTTNNFH 292
Query: 316 NKYVSPISKYYKEQSVLENFHA---------DIYLDILSHYWPELSQEFTG-IKDSIIAT 365
S + Y +++VLEN HA D Y +ILSH E +E G + + ++ T
Sbjct: 293 VMSGSETALLYNDRAVLENHHASASFRLLREDEY-NILSHLSREEFRELRGLVIEMVLGT 351
Query: 366 DMALHNHYVETIK-----QETGPNLTGLTSLIIKAADISNVTRPLLISAKWAALISMEFK 420
DM H ++ ++ QE + + SL++ DIS+ + + +W L+ EF
Sbjct: 352 DMTNHFQQMKAMRQLLTLQEATIDKQKVLSLVLHCCDISHPAKQWGVHHRWTMLLLEEFF 411
Query: 421 ECAVLEKNL 429
LEK L
Sbjct: 412 RQGDLEKEL 420
>7291615 [T] KOG1229 3'5'-cyclic nucleotide phosphodiesterases
Length = 1060
Score = 77.0 bits (188), Expect = 6e-14
Identities = 74/250 (29%), Positives = 109/250 (43%), Gaps = 48/250 (19%)
Query: 209 SWDFCAHSLN-CTELIWCAYL---------LFHKLNTESNLSHAPPSTNRLLLMLLNIEA 258
SWDF L T+ YL +F LN + N+ A L IEA
Sbjct: 727 SWDFDIFKLEEITDYHPLLYLGMEMFRRFDVFATLNIDENVCKA---------WLAVIEA 777
Query: 259 AYHQGNKFHNFRHAVDVLQAT----YQLCH--LLELPKLASFLLCIAAIGHDVAHPGTNN 312
Y + N +HN HA DV+QAT QL + +L + ++ IAA HDV HPG ++
Sbjct: 778 HYRKSNTYHNSTHAADVMQATGAFITQLTNKDMLVMDRMEEATALIAAAAHDVDHPGRSS 837
Query: 313 MLFNKYVSPISKYYKEQSVLENFHADIYL-----DILSHYWPELSQEF-----TGIKDSI 362
++ Y + +VLEN HA I D + + L +E + I D I
Sbjct: 838 AFLCNSNDALAVLYNDLTVLENHHAAITFKLTLGDDKINIFKNLDKETYKSARSTIIDMI 897
Query: 363 IATDMALH-NHYVETIK-------QETGPNLTGLTS-----LIIKAADISNVTRPLLISA 409
+AT+M H H + + ++ P TS ++IK AD+SN RP+
Sbjct: 898 LATEMTRHFEHLAKFVSVFGGEEPRDHNPQTDEETSILMRRMLIKVADVSNPARPMQFCI 957
Query: 410 KWAALISMEF 419
+WA I+ E+
Sbjct: 958 EWARRIAEEY 967
>Hs5453862 [T] KOG3689 Cyclic nucleotide phosphodiesterase
Length = 647
Score = 76.3 bits (186), Expect = 1e-13
Identities = 75/293 (25%), Positives = 123/293 (41%), Gaps = 58/293 (19%)
Query: 249 LLLMLLNIEAAYHQGNKFHNFRHAVDVLQATYQLCHLLELPKLASFLLCIAAIG----HD 304
++ +L +E YH +HN HA DVLQ+T+ L L + + L +AA+ HD
Sbjct: 176 MVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHD 235
Query: 305 VAHPGTNNMLFNKYVSPISKYYKEQSVLENFHADIYLDILSHYWPELSQEFTG------- 357
V HPG +N S ++ Y ++SVLEN H + +L ++ Q +
Sbjct: 236 VDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLR 295
Query: 358 --IKDSIIATDMALH-------NHYVETIKQETGPNLTGLTSL---------IIKAADIS 399
+ D ++ATDM+ H VET K+ T + L + ++ AD+S
Sbjct: 296 KMVIDMVLATDMSKHMTLLADLKTMVET-KKVTSSGVLLLDNYSDRIQVLRNMVHCADLS 354
Query: 400 NVTRPLLISAKWAALISMEFKECAVLEKNLVELADAKDDEKKRISYKLDLDFDSYSELPS 459
N T+PL + +W I EF + D + + IS D
Sbjct: 355 NPTKPLELYRQWTDRIMAEF----------FQQGDRERERGMEISPMCD----------- 393
Query: 460 NIDDILKEFPNIPKGQAFFIDTFALSLF-SGLGLKYKQLQFLVDNVENNRKFW 511
K ++ K Q FID L+ + L + Q ++D +E+NR ++
Sbjct: 394 ------KHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWY 440
>7290408 [T] KOG3689 Cyclic nucleotide phosphodiesterase
Length = 624
Score = 74.7 bits (182), Expect = 3e-13
Identities = 72/246 (29%), Positives = 108/246 (43%), Gaps = 37/246 (15%)
Query: 207 LDSWD---FCAHSLNCTELIWC-AYLLFHKLNTESNLSHAPPSTNRLLLMLLNIEAAYHQ 262
LD+W F + + C AY +F ++L PP T L + +E Y +
Sbjct: 225 LDTWGIQIFSIGEFSVNRPLTCVAYTIFQSRELLTSLM-IPPKT--FLNFMSTLEDHYVK 281
Query: 263 GNKFHNFRHAVDVLQATYQLCHLLELPKLASFL----LCIAAIGHDVAHPGTNNMLFNKY 318
N FHN HA DV Q+T L + L + + L AA HDV HPG N
Sbjct: 282 DNPFHNSLHAADVTQSTNVLLNTPALEGVFTPLEVGGALFAACIHDVDHPGLTNQFLVNS 341
Query: 319 VSPISKYYKEQSVLENFHADIYLDILSHYWPEL------SQEFTGIK---DSIIATDMAL 369
S ++ Y ++SVLEN H + +L + ++ Q T K D +++TDM+
Sbjct: 342 SSELALMYNDESVLENHHLAVAFKLLQNQGCDIFCNMQKKQRQTLRKMVIDIVLSTDMSK 401
Query: 370 H-------NHYVETIKQETGPNLTGLTSL---------IIKAADISNVTRPLLISAKWAA 413
H VET K+ G + L + ++ AD+SN T+PL + +W A
Sbjct: 402 HMSLLADLKTMVET-KKVAGSGVLLLDNYTDRIQVLENLVHCADLSNPTKPLPLYKRWVA 460
Query: 414 LISMEF 419
L+ EF
Sbjct: 461 LLMEEF 466
>Hs4505677 [T] KOG3688 Cyclic GMP phosphodiesterase
Length = 536
Score = 74.3 bits (181), Expect = 4e-13
Identities = 70/236 (29%), Positives = 104/236 (43%), Gaps = 23/236 (9%)
Query: 205 KCLDSWDFCAHSLNCTELIWCAYLLFHKLNTESNL-SHAPPSTNRLLLMLLNIEAAYHQ- 262
K LD W F SLN + +L T NL S T L+ L +E Y +
Sbjct: 159 KNLDLWCFDVFSLNQAADDHALRTIVFELLTRHNLISRFKIPTVFLMSFLDALETGYGKY 218
Query: 263 GNKFHNFRHAVDVLQATYQLCHLLE------LPKLASFLLCIAAIGHDVAHPGTNNMLFN 316
N +HN HA DV Q + C LL L ++ + AA HD H GT N
Sbjct: 219 KNPYHNQIHAADVTQTVH--CFLLRTGMVHCLSEIELLAIIFAAAIHDYEHTGTTNSFHI 276
Query: 317 KYVSPISKYYKEQSVLENFHADIYL-----DILSHYWPELSQEFTGIK----DSIIATDM 367
+ S + Y ++SVLEN H D ++ + EF ++ + ++ATDM
Sbjct: 277 QTKSECAIVYNDRSVLENHHISSVFRLMQDDEMNIFINLTKDEFVELRALVIEMVLATDM 336
Query: 368 ALHNHYVETIK----QETGPNLTGLTSLIIKAADISNVTRPLLISAKWAALISMEF 419
+ H V+T+K Q + SL++ AADIS+ T+ L+ ++W + EF
Sbjct: 337 SCHFQQVKTMKTALQQLERIDKPKALSLLLHAADISHPTKQWLVHSRWTKALMEEF 392
>Hs4505663 [T] KOG3689 Cyclic nucleotide phosphodiesterase
Length = 564
Score = 73.9 bits (180), Expect = 5e-13
Identities = 74/296 (25%), Positives = 120/296 (40%), Gaps = 56/296 (18%)
Query: 245 STNRLLLMLLNIEAAYHQGNKFHNFRHAVDVLQATYQLCHLLELPKLASFLLCIAAIG-- 302
S++ + ++ +E YH +HN HA DV Q+T+ L L + + L +AAI
Sbjct: 212 SSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAA 271
Query: 303 --HDVAHPGTNNMLFNKYVSPISKYYKEQSVLENFHADIYLDILSHYWPELSQEFTG--- 357
HDV HPG +N S ++ Y ++SVLEN H + +L ++ T
Sbjct: 272 AIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQR 331
Query: 358 ------IKDSIIATDMALH-------NHYVETIKQETG-----PNLTGLTSLI---IKAA 396
+ D ++ATDM+ H VET K + N T ++ + A
Sbjct: 332 QTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCA 391
Query: 397 DISNVTRPLLISAKWAALISMEFKECAVLEKNLVELADAKDDEKKRISYKLDLDFDSYSE 456
D+SN T+ L + +W I EF + D + + IS D
Sbjct: 392 DLSNPTKSLELYRQWTDRIMEEF----------FQQGDKERERGMEISPMCD-------- 433
Query: 457 LPSNIDDILKEFPNIPKGQAFFIDTFALSLF-SGLGLKYKQLQFLVDNVENNRKFW 511
K ++ K Q FID L+ + L Q ++D +E+NR ++
Sbjct: 434 ---------KHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWY 480
>CE28641 [T] KOG3689 Cyclic nucleotide phosphodiesterase
Length = 626
Score = 73.6 bits (179), Expect = 7e-13
Identities = 78/295 (26%), Positives = 126/295 (42%), Gaps = 57/295 (19%)
Query: 249 LLLMLLNIEAAYHQGNKFHNFRHAVDVLQATYQLCHLLELPKLASFLLCIAAI----GHD 304
L+ LLN+E Y + N +HNF HA DV Q+ + L L ++ + L +AAI HD
Sbjct: 342 LVTYLLNLEHHY-RNNHYHNFIHAADVAQSMHVLLMSPVLTEVFTDLEVLAAIFAGAVHD 400
Query: 305 VAHPGTNNMLFNKYVSPISKYYKEQSVLENFH--------ADIYLDILSHYWPELSQEFT 356
V HPG N + ++ Y ++SVLE H D D L++ + +F
Sbjct: 401 VDHPGFTNQYLINSNNELAIMYNDESVLEQHHLAVAFKLLQDSNCDFLANLSRKQRLQFR 460
Query: 357 GIK-DSIIATDMALHNHYVETI------KQETGPNLTGLTSL---------IIKAADISN 400
I D ++ATDM+ H + + K+ G N+ L +I AD+SN
Sbjct: 461 KIVIDMVLATDMSKHMSLLADLKTMVEAKKVAGNNVIVLDKYNDKIQVLQSMIHLADLSN 520
Query: 401 VTRPLLISAKWAALISMEFKECAVLEKNLVELADAKDDEKKRISYKLDLDFDSYSELPSN 460
T+P+ + +W I E+ + D++K + ++ D N
Sbjct: 521 PTKPIELYQQWNQRIMEEYWR--------------QGDKEKELGLEISPMCDR-----GN 561
Query: 461 IDDILKEFPNIPKGQAFFIDTFALSLF-SGLGLKYKQLQFLVDNVENNRKFWMER 514
+ I K Q FID L+ + L Y Q ++D +E NR+++ R
Sbjct: 562 V--------TIEKSQVGFIDYIVHPLYETWADLVYPDAQNILDQLEENREWYQSR 608
>CE02038 [T] KOG3689 Cyclic nucleotide phosphodiesterase
Length = 549
Score = 73.6 bits (179), Expect = 7e-13
Identities = 78/295 (26%), Positives = 126/295 (42%), Gaps = 57/295 (19%)
Query: 249 LLLMLLNIEAAYHQGNKFHNFRHAVDVLQATYQLCHLLELPKLASFLLCIAAI----GHD 304
L+ LLN+E Y + N +HNF HA DV Q+ + L L ++ + L +AAI HD
Sbjct: 265 LVTYLLNLEHHY-RNNHYHNFIHAADVAQSMHVLLMSPVLTEVFTDLEVLAAIFAGAVHD 323
Query: 305 VAHPGTNNMLFNKYVSPISKYYKEQSVLENFH--------ADIYLDILSHYWPELSQEFT 356
V HPG N + ++ Y ++SVLE H D D L++ + +F
Sbjct: 324 VDHPGFTNQYLINSNNELAIMYNDESVLEQHHLAVAFKLLQDSNCDFLANLSRKQRLQFR 383
Query: 357 GIK-DSIIATDMALHNHYVETI------KQETGPNLTGLTSL---------IIKAADISN 400
I D ++ATDM+ H + + K+ G N+ L +I AD+SN
Sbjct: 384 KIVIDMVLATDMSKHMSLLADLKTMVEAKKVAGNNVIVLDKYNDKIQVLQSMIHLADLSN 443
Query: 401 VTRPLLISAKWAALISMEFKECAVLEKNLVELADAKDDEKKRISYKLDLDFDSYSELPSN 460
T+P+ + +W I E+ + D++K + ++ D N
Sbjct: 444 PTKPIELYQQWNQRIMEEYWR--------------QGDKEKELGLEISPMCDR-----GN 484
Query: 461 IDDILKEFPNIPKGQAFFIDTFALSLF-SGLGLKYKQLQFLVDNVENNRKFWMER 514
+ I K Q FID L+ + L Y Q ++D +E NR+++ R
Sbjct: 485 V--------TIEKSQVGFIDYIVHPLYETWADLVYPDAQNILDQLEENREWYQSR 531
>Hs19923440 [T] KOG3689 Cyclic nucleotide phosphodiesterase
Length = 934
Score = 72.0 bits (175), Expect = 2e-12
Identities = 85/335 (25%), Positives = 143/335 (42%), Gaps = 63/335 (18%)
Query: 207 LDSWDFCAHSLNCTELIWCAYLLFHKLNTESNLSHAPPSTNRLLLMLLNIEAAYHQGNKF 266
+D F SL+ +I A +F +L L LL + Y +
Sbjct: 608 IDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKI---DYETLCRWLLTVRKNYRMV-LY 663
Query: 267 HNFRHAVDVLQATYQLCH-------LLELPKLASFLLCIAAIGHDVAHPGTNNMLFNKYV 319
HN+RHA +V Q + + L E+ LA + C+ HD+ H GTNN K
Sbjct: 664 HNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLC---HDLDHRGTNNAFQAKSG 720
Query: 320 SPISKYYKEQSVLENFH------------ADIYLDILSHYWPELSQEFTGIKDSIIATDM 367
S +++ Y + LE+ H +I+ ++ S + +L Q +K SI+ATD+
Sbjct: 721 SALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQL---LKQSILATDL 777
Query: 368 ALH----NHYVETI-KQETGPNLTG----LTSLIIKAADISNVTRPLLISAKWAALISME 418
L+ + E + K E N+ S+++ A D+ VT+P IS + A L++ E
Sbjct: 778 TLYFERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSE 837
Query: 419 FKECAVLEKNLVELADAKDDEKKRISYKLDLDFDSYSELPSNIDDILKEFPNIPKGQAFF 478
F E +++R+ KL PS I D ++ +P+ Q +
Sbjct: 838 FFE---------------QGDRERLELKL---------TPSAIFDRNRK-DELPRLQLEW 872
Query: 479 IDTFALSLFSGLGLKYKQLQFLVDNVENNRKFWME 513
ID+ + L+ L +L+ ++D+V NR W E
Sbjct: 873 IDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEE 907
>Hs4585864 [T] KOG3689 Cyclic nucleotide phosphodiesterase
Length = 860
Score = 71.6 bits (174), Expect = 3e-12
Identities = 80/362 (22%), Positives = 155/362 (42%), Gaps = 65/362 (17%)
Query: 187 DITDMIKSNLSHNDAYYWKCLDSWDFCAHSLNCTELIWCAYLLFHKLNTESNLSHAPPST 246
++ +++++ L D Y ++ + F L EL+ C ++++L H P
Sbjct: 486 ELAEILQAELPDADKYE---INKFHFSDLPLTELELVKCGIQMYYELKVVDKF-HIPQEA 541
Query: 247 NRLLLMLLNIEAAYHQGNKFHNFRHAVDVLQATYQLCHLLELPK----LASFLLCIAAIG 302
L+ + ++ Y + +HN+RH +V Q + L +L + L + + AA
Sbjct: 542 --LVRFMYSLSKGYRKIT-YHNWRHGFNVGQTMFSLLVTGKLKRYFTDLEALAMVTAAFC 598
Query: 303 HDVAHPGTNNMLFNKYVSPISKYYKEQSVLENFH--------ADIYLDILSHYWPELSQE 354
HD+ H GTNN+ K +P++K + S+LE H D L+I + +
Sbjct: 599 HDIDHRGTNNLYQMKSQNPLAKLH-GSSILERHHLEFGKTLLRDESLNIFQNLNRRQHEH 657
Query: 355 FTGIKD-SIIATDMALH-------------NHYVETIKQETGPNLTGLT------SLIIK 394
+ D +IIATD+AL+ + E+ ++ T + T ++++
Sbjct: 658 AIHMMDIAIIATDLALYFKKRTMFQKIVDQSKTYESEQEWTQYMMLEQTRKEIVMAMMMT 717
Query: 395 AADISNVTRPLLISAKWAALISMEFKECAVLEKNLVELADAKDDEKKRISYKLDLDFDSY 454
A D+S +T+P + ++ A L++ EF E LE+ +++
Sbjct: 718 ACDLSAITKPWEVQSQVALLVAAEFWEQGDLERTVLQ----------------------Q 755
Query: 455 SELPSNIDDILKEFPNIPKGQAFFIDTFALSLFSGLGLKYKQLQFLVDNVENNRKFWMER 514
+ +P + E P + G F+ TF FS ++++ ++D + NNRK W
Sbjct: 756 NPIPMMDRNKADELPKLQVGFIDFVCTFVYKEFSRF---HEEITPMLDGITNNRKEWKAL 812
Query: 515 GD 516
D
Sbjct: 813 AD 814
>Hs4826894 [T] KOG3688 Cyclic GMP phosphodiesterase
Length = 634
Score = 69.3 bits (168), Expect = 1e-11
Identities = 64/235 (27%), Positives = 104/235 (44%), Gaps = 20/235 (8%)
Query: 205 KCLDSWDFCAHSLNCTELIWCAYLLFHKLNTESNL-SHAPPSTNRLLLMLLNIEAAYHQG 263
K +D W F SLN +F++L T +L S + L+ + +E Y +
Sbjct: 164 KDVDKWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSKH 223
Query: 264 -NKFHNFRHAVDVLQATYQLCHLLE----LPKLASFLLCIAAIGHDVAHPGTNNMLFNKY 318
N +HN HA DV Q + L + L +L F + +A HD H GT N +
Sbjct: 224 KNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQT 283
Query: 319 VSPISKYYKEQSVLENFHA---------DIYLDILSHYWPELSQEF-TGIKDSIIATDMA 368
S + Y ++SVLEN H D ++IL + + +EF T + + ++ATDM+
Sbjct: 284 RSDPAILYNDRSVLENHHLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIEMVMATDMS 343
Query: 369 LHNHYVETIK----QETGPNLTGLTSLIIKAADISNVTRPLLISAKWAALISMEF 419
H ++ +K Q SL++ ADIS+ + + +W + EF
Sbjct: 344 CHFQQIKAMKTALQQPEAIEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEF 398
>HsM4826892 [T] KOG3688 Cyclic GMP phosphodiesterase
Length = 535
Score = 67.0 bits (162), Expect = 6e-11
Identities = 61/237 (25%), Positives = 103/237 (42%), Gaps = 25/237 (10%)
Query: 205 KCLDSWDFCAHSLNCTELIWCAYLLFHKLNTESNL-SHAPPSTNRLLLMLLNIEAAYHQ- 262
K +D W F +LN + ++L T +L + + L+ +E Y +
Sbjct: 155 KDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKY 214
Query: 263 GNKFHNFRHAVDVLQAT-YQLCH---LLELPKLASFLLCIAAIGHDVAHPGTNNMLFNKY 318
N +HN HA DV Q Y + H + L +L + AA HD H GT N +
Sbjct: 215 KNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQT 274
Query: 319 VSPISKYYKEQSVLENFHA------------DIYLDILSHYWPELSQEFTGIKDSIIATD 366
S ++ Y ++SVLEN H +I +++ W +L + + +++TD
Sbjct: 275 RSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNL---VIEMVLSTD 331
Query: 367 MALHNHYVETIK----QETGPNLTGLTSLIIKAADISNVTRPLLISAKWAALISMEF 419
M+ H ++ I+ Q G + SLI+ AADIS+ + + +W + EF
Sbjct: 332 MSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEF 388
>Hs21361262 [T] KOG3688 Cyclic GMP phosphodiesterase
Length = 545
Score = 67.0 bits (162), Expect = 6e-11
Identities = 61/237 (25%), Positives = 103/237 (42%), Gaps = 25/237 (10%)
Query: 205 KCLDSWDFCAHSLNCTELIWCAYLLFHKLNTESNL-SHAPPSTNRLLLMLLNIEAAYHQ- 262
K +D W F +LN + ++L T +L + + L+ +E Y +
Sbjct: 155 KDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKY 214
Query: 263 GNKFHNFRHAVDVLQAT-YQLCH---LLELPKLASFLLCIAAIGHDVAHPGTNNMLFNKY 318
N +HN HA DV Q Y + H + L +L + AA HD H GT N +
Sbjct: 215 KNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQT 274
Query: 319 VSPISKYYKEQSVLENFHA------------DIYLDILSHYWPELSQEFTGIKDSIIATD 366
S ++ Y ++SVLEN H +I +++ W +L + + +++TD
Sbjct: 275 RSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNL---VIEMVLSTD 331
Query: 367 MALHNHYVETIK----QETGPNLTGLTSLIIKAADISNVTRPLLISAKWAALISMEF 419
M+ H ++ I+ Q G + SLI+ AADIS+ + + +W + EF
Sbjct: 332 MSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEF 388
>HsM5453866 [T] KOG3689 Cyclic nucleotide phosphodiesterase
Length = 858
Score = 65.1 bits (157), Expect = 2e-10
Identities = 74/327 (22%), Positives = 128/327 (38%), Gaps = 62/327 (18%)
Query: 222 LIWCAYLLFHKLNTESNLSHAPPSTNRLLLMLLNIEAAYHQGNKFHNFRHAVDVLQATYQ 281
LI C LF ++N R + + Y + +HN+RH +V Q +
Sbjct: 521 LIKCGIRLFFEINVVEKFKVPVEVLTR---WMYTVRKGY-RAVTYHNWRHGFNVGQTMFT 576
Query: 282 LCHLLELPK----LASFLLCIAAIGHDVAHPGTNNMLFNKYVSPISKYYKEQSVLENFHA 337
L L K L +F + AA HD+ H GTNN+ K SP+++ + S+LE H
Sbjct: 577 LLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLH-GSSILERHHL 635
Query: 338 DIYLDILSHYWPELSQEFTG---------IKDSIIATDMALH-----------------N 371
+ +L + Q + +IIATD+AL+
Sbjct: 636 EYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQ 695
Query: 372 HYVETIKQET--GPNLTGLTSLIIKAADISNVTRPLLISAKWAALISMEFKECAVLEKNL 429
E IK T + ++++ A D+S +T+P + ++ A +++ EF E LE+ +
Sbjct: 696 TEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTV 755
Query: 430 VELADAKDDEKKRISYKLDLDFDSYSELPSNIDDILKEFPNIPKGQAFFIDTFALSLFSG 489
++ +P + E P + G F+ TF FS
Sbjct: 756 LQ----------------------QQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSR 793
Query: 490 LGLKYKQLQFLVDNVENNRKFWMERGD 516
+K++ ++ ++NNR W D
Sbjct: 794 F---HKEITPMLSGLQNNRVEWKSLAD 817
>Hs21361308 [T] KOG3689 Cyclic nucleotide phosphodiesterase
Length = 858
Score = 63.5 bits (153), Expect = 7e-10
Identities = 73/327 (22%), Positives = 128/327 (38%), Gaps = 62/327 (18%)
Query: 222 LIWCAYLLFHKLNTESNLSHAPPSTNRLLLMLLNIEAAYHQGNKFHNFRHAVDVLQATYQ 281
LI C LF ++N R + + Y + +HN++H +V Q +
Sbjct: 521 LIKCGIRLFFEINVVEKFKVPVEVLTR---WMYTVRKGY-RAVTYHNWQHGFNVGQTMFT 576
Query: 282 LCHLLELPK----LASFLLCIAAIGHDVAHPGTNNMLFNKYVSPISKYYKEQSVLENFHA 337
L L K L +F + AA HD+ H GTNN+ K SP+++ + S+LE H
Sbjct: 577 LLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLH-GSSILERHHL 635
Query: 338 DIYLDILSHYWPELSQEFTG---------IKDSIIATDMALH-----------------N 371
+ +L + Q + +IIATD+AL+
Sbjct: 636 EYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQ 695
Query: 372 HYVETIKQET--GPNLTGLTSLIIKAADISNVTRPLLISAKWAALISMEFKECAVLEKNL 429
E IK T + ++++ A D+S +T+P + ++ A +++ EF E LE+ +
Sbjct: 696 TEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTV 755
Query: 430 VELADAKDDEKKRISYKLDLDFDSYSELPSNIDDILKEFPNIPKGQAFFIDTFALSLFSG 489
++ +P + E P + G F+ TF FS
Sbjct: 756 LQ----------------------QQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSR 793
Query: 490 LGLKYKQLQFLVDNVENNRKFWMERGD 516
+K++ ++ ++NNR W D
Sbjct: 794 F---HKEITPMLSGLQNNRVEWKSLAD 817
>CE16340 [T] KOG3688 Cyclic GMP phosphodiesterase
Length = 664
Score = 63.2 bits (152), Expect = 9e-10
Identities = 61/240 (25%), Positives = 99/240 (40%), Gaps = 19/240 (7%)
Query: 209 SWDFCAHSLN-CTELIWCAYLLFHKLNTESNLSHAPPSTNRLLLMLLNIEAAYHQ-GNKF 266
+W F LN +E Y+ F N + L L +E Y + N +
Sbjct: 273 TWSFSPFQLNEVSEGHALKYVGFELFNRYGFMDRFKVPLTALENYLSALEVGYSKHNNPY 332
Query: 267 HNFRHAVDVLQATYQLCHLLELPKLASFLLCIA----AIGHDVAHPGTNNMLFNKYVSPI 322
HN HA DV Q+++ + L L +A A+ HD H G N + S
Sbjct: 333 HNVVHAADVTQSSHFMLSQTGLANSLGDLELLAVLFGALIHDYEHTGHTNNFHIQSQSQF 392
Query: 323 SKYYKEQSVLENFHADIYL--------DILSHYWPELSQEFTG-IKDSIIATDMALHNHY 373
+ Y ++SVLEN H +IL+H + +E + + ++ATDM+ H
Sbjct: 393 AMLYNDRSVLENHHVSSCFRLMKEDDKNILTHLTRDEYKELRNMVIEIVLATDMSTHFMQ 452
Query: 374 VETIKQ----ETGPNLTGLTSLIIKAADISNVTRPLLISAKWAALISMEFKECAVLEKNL 429
++T+K G + LI+ A DIS+ +P + +W + EF LE ++
Sbjct: 453 IKTMKSMLSLPEGIDKNKALCLIVHACDISHPAKPWNLHERWTEGVLEEFFRQGDLEASM 512
>Hs4505657 [T] KOG3689 Cyclic nucleotide phosphodiesterase
Length = 941
Score = 59.7 bits (143), Expect = 1e-08
Identities = 81/344 (23%), Positives = 142/344 (40%), Gaps = 36/344 (10%)
Query: 147 SEEHHDLPCSNNLY---TMASHLAYVNSNDRLKRERVP---IWDYIDITDMIKSNLSHND 200
S+ DL + ++Y ++A L Y N+ R + + ++ ++D + L H+
Sbjct: 530 SKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHDG 589
Query: 201 AYYWKCLDS----WDFCAHSLNCTELIWCAYLLFHKLNTESNLSHAPPSTNRLLLMLLNI 256
+DS + + SL + + +N +N P+ R LM +
Sbjct: 590 IQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLM---V 646
Query: 257 EAAYHQGNKFHNFRHAVDVLQATYQLCHLLELPK----LASFLLCIAAIGHDVAHPGTNN 312
+ Y +HN+ HA V Y L LEL + F L I+ + HD+ H GTNN
Sbjct: 647 KKGYRDP-PYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNN 705
Query: 313 MLFNKYVSPISKYY-KEQSVLENFHADIYLDILSHYWPELSQEFTG---------IKDSI 362
S ++ Y E SV+E H + IL+ + + F+ ++D I
Sbjct: 706 SFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDII 765
Query: 363 IATDMALHNHYVETIKQ--ETGPNLTG------LTSLIIKAADISNVTRPLLISAKWAAL 414
+ATD+A H + +++ E G + L L++ + D+S+ T+ + K A L
Sbjct: 766 LATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAEL 825
Query: 415 ISMEFKECAVLEKNLVELADAKDDEKKRISYKLDLDFDSYSELP 458
I EF LEK + D +K +L + F + +P
Sbjct: 826 IYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFMEHIAMP 869
>CE24876 [T] KOG3688 Cyclic GMP phosphodiesterase
Length = 562
Score = 51.6 bits (122), Expect = 3e-06
Identities = 54/203 (26%), Positives = 79/203 (38%), Gaps = 49/203 (24%)
Query: 266 FHNFRHAVDVLQATYQLCH-----------------------------LLELPKLASFLL 296
+HN HA DVL Y L + +L L L
Sbjct: 134 YHNRIHAADVLHGCYYLSAHPVRSTFLTPKTPDSVLTPPHPHHQHSSIMSQLSTLELMAL 193
Query: 297 CIAAIGHDVAHPGTNNMLFNKYVSPISKYYKEQSVLENFHADIYLDIL----SHYW---- 348
AA HD HPG N + + Y ++SVLEN HA +L +H+
Sbjct: 194 FTAAAMHDYDHPGRTNAFLVQVEDKKAILYNDRSVLENHHAAESWKLLNKPENHFIENLD 253
Query: 349 -PELSQEFTGIKDSIIATDMALHNHYVET---------IKQETGPNLTGLTSLIIKAADI 398
E+ + + + I+ATD+ H + T ++ ET L G L+IK ADI
Sbjct: 254 PAEMKRFRYLVLEYILATDLKQHFEIIMTFTERLTEIDVQVETDRLLIG--KLLIKMADI 311
Query: 399 SNVTRPLLISAKWAALISMEFKE 421
++ T+P + +W I EF E
Sbjct: 312 NSPTKPYGLHRQWTDRICEEFYE 334
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.322 0.136 0.420
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,212,963
Number of Sequences: 60738
Number of extensions: 1423021
Number of successful extensions: 3679
Number of sequences better than 1.0e-05: 33
Number of HSP's better than 0.0 without gapping: 1
Number of HSP's successfully gapped in prelim test: 32
Number of HSP's that attempted gapping in prelim test: 3588
Number of HSP's gapped (non-prelim): 38
length of query: 516
length of database: 30,389,216
effective HSP length: 111
effective length of query: 405
effective length of database: 23,647,298
effective search space: 9577155690
effective search space used: 9577155690
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)