ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactI1075 good T KOG3417 Signal transduction mechanisms Ras1 guanine nucleotide exchange factor
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactI1075 365428 361331 -1366
(1366 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YAL024c [T] KOG3417 Ras1 guanine nucleotide exchange factor 831 0.0
SPBC336.03 [T] KOG3417 Ras1 guanine nucleotide exchange factor 89 5e-17
Hs19923151 [T] KOG3417 Ras1 guanine nucleotide exchange factor 88 1e-16
YLR310c [T] KOG3417 Ras1 guanine nucleotide exchange factor 84 1e-15
Hs8922307 [T] KOG3417 Ras1 guanine nucleotide exchange factor 82 8e-15
Hs20546742 [T] KOG3417 Ras1 guanine nucleotide exchange factor 81 1e-14
Hs7662070 [T] KOG3417 Ras1 guanine nucleotide exchange factor 78 1e-13
SPCC1442.01 [T] KOG3417 Ras1 guanine nucleotide exchange factor 77 2e-13
Hs5901914 [T] KOG2378 cAMP-regulated guanine nucleotide exchange... 75 5e-13
7302879 [T] KOG3417 Ras1 guanine nucleotide exchange factor 74 2e-12
7302878 [T] KOG3417 Ras1 guanine nucleotide exchange factor 74 2e-12
7302302 [T] KOG2378 cAMP-regulated guanine nucleotide exchange f... 73 4e-12
CE23992 [T] KOG2378 cAMP-regulated guanine nucleotide exchange f... 70 2e-11
Hs6912456 [T] KOG2378 cAMP-regulated guanine nucleotide exchange... 67 2e-10
CE28081 [T] KOG3542 cAMP-regulated guanine nucleotide exchange f... 65 6e-10
CE28080 [T] KOG3542 cAMP-regulated guanine nucleotide exchange f... 65 6e-10
CE07423 [T] KOG3541 Predicted guanine nucleotide exchange factor 63 3e-09
7297097 [T] KOG3542 cAMP-regulated guanine nucleotide exchange f... 63 3e-09
7290754 [T] KOG3417 Ras1 guanine nucleotide exchange factor 62 8e-09
Hs22046650 [T] KOG3629 Guanine-nucleotide releasing factor 61 1e-08
Hs20149570 [T] KOG3417 Ras1 guanine nucleotide exchange factor 61 1e-08
Hs4885357 [T] KOG3417 Ras1 guanine nucleotide exchange factor 59 4e-08
Hs4758532 [T] KOG3629 Guanine-nucleotide releasing factor 56 3e-07
CE05713 [T] KOG3417 Ras1 guanine nucleotide exchange factor 56 4e-07
Hs7662334 [T] KOG3417 Ras1 guanine nucleotide exchange factor 55 8e-07
Hs20127536 [T] KOG3629 Guanine-nucleotide releasing factor 55 8e-07
Hs7705939 [T] KOG2378 cAMP-regulated guanine nucleotide exchange... 55 1e-06
Hs7657261 [T] KOG3542 cAMP-regulated guanine nucleotide exchange... 54 1e-06
Hs15529996 [T] KOG3417 Ras1 guanine nucleotide exchange factor 53 3e-06
7302774 [T] KOG3541 Predicted guanine nucleotide exchange factor 52 5e-06
Hs7706513 [T] KOG3542 cAMP-regulated guanine nucleotide exchange... 52 6e-06
Hs5032025 [T] KOG3417 Ras1 guanine nucleotide exchange factor 52 6e-06
Hs20070215 [T] KOG2378 cAMP-regulated guanine nucleotide exchang... 52 8e-06
>YAL024c [T] KOG3417 Ras1 guanine nucleotide exchange factor
Length = 1435
Score = 831 bits (2147), Expect = 0.0
Identities = 552/1488 (37%), Positives = 824/1488 (55%), Gaps = 197/1488 (13%)
Query: 15 LFSRPELYPVPSESVLTVDLRDGTVRILKCTLPALLVQLSSPLDKVDYSMLTDFFLVYRN 74
+FS+ + YP PS +V++ + + + LPAL+V LSSPL+ VDY+ DFFL+YRN
Sbjct: 3 IFSQKDYYPTPSSNVISYESDCVSKPVNSADLPALIVHLSSPLEGVDYNASADFFLIYRN 62
Query: 75 FMSSQKLLDLIQERFQWAI-DLRQSDPSSQEKITSEVILVRMFVLVRHWLSNYFAQDFVV 133
F++ Q L DL+ RF+W I ++ + ++ + EV LVR FVL+RH + NYF QDF+
Sbjct: 63 FITPQDLHDLLIYRFRWCIREITTNAAKAKRRRIGEVALVRTFVLLRHSILNYFVQDFLP 122
Query: 134 DTSLRRQFLQFING--YSPVDRFLDNIIISLKKLWVQNVQIMWEDLENLIVENNVVSRDD 191
+ +LR + ++F+N + + + II+LKK WV +++WE++E + E + + D
Sbjct: 123 NITLRLRLIEFLNDKHIEQYPKIISSCIINLKKNWVHCSKLVWENIE--LNEPDKLDFDA 180
Query: 192 WLKWEIEDVPXXXXXXXXXXXXXXXRLSFIALQNINNPVLRNESLLSLLHTREKIPLPQQ 251
WL + ++D RLS A Q+ +P RN+S+LSL T + LP++
Sbjct: 181 WLHYSLKDF-----TQLESLHKRGSRLSIYARQSFASPDFRNQSVLSLYKTSDVFRLPEK 235
Query: 252 SEDESKKQSTRIKQRTGSMLLFPENASNGLSINEKLTASGVSPEATPKQEREITDPKNSK 311
+ + ++ QR+ SMLLFP+N SN S + ++ E + E E +
Sbjct: 236 LQSSNSSKN----QRSPSMLLFPDNTSNVYSKHR------IAKEPSVDNESE-----DMS 280
Query: 312 DNKHILPQLSRVTNVSYMMKDLEYPSTPSVDIFVPPTPAKNIEFILQTSYMETDLPEQSN 371
D+K + LS+VT VS +MK ++YPS+ +VD +PPTPAK +EFIL + Y+ DL EQS
Sbjct: 281 DSKQKISHLSKVTLVSTLMKGVDYPSSYAVDKIMPPTPAKKVEFILNSLYIPEDLNEQSG 340
Query: 372 GSDSTNTVNG--NNTN-------------HKGILGLLSKWKLNHQRKPTVN--------- 407
T+T + NN+N H+ +GLL+KW NH R + N
Sbjct: 341 TLQGTSTTSSLDNNSNSNSRSNTSSMSVLHRSAIGLLAKWMKNHNRHDSSNDKKFMSAIK 400
Query: 408 PVQNPPRVENLIKYVFSISSLDNHANPLPD-----SLSSMFDILSARTIDEVEYLVSVES 462
P P ++ +KYV SISSL+ ++ + S SS FDILSARTIDEVE L+ +++
Sbjct: 401 PANQKPEMDAFVKYVVSISSLNRKSSKEEEEEFLNSDSSKFDILSARTIDEVESLLHLQN 460
Query: 463 DXXXXXXXXXXXXX----------------ISKLETN--EDESQDYSVIDNLNLYKTVSS 504
I L+ N + + ++S +DNL+LY+TVSS
Sbjct: 461 QLIEKVQTHSNNNRGPTVNVDCERREHIHDIKILQQNSFKPSNDNFSAMDNLDLYQTVSS 520
Query: 505 IANSVISLSKTLNVRTNKSTTHLL-SPSTSALERKNIRNSAPMLYSYNNSRYSITNALM- 562
IA SVISL+ TLN + + +++ SPS AL+R+ +++ Y+ + YS + +
Sbjct: 521 IAQSVISLTNTLNKQLQNNESNMQPSPSYDALQRRKVKSLTTAYYNKMHGSYSAESMRLF 580
Query: 563 ---GLPNTNDNSSPKRLVFHDPTR---------------NSPTKKAILANNLNNI----- 599
+ D + P+RL+FH+ + +S ++K++ ++ L N+
Sbjct: 581 DKDNSSSRTDENGPQRLLFHETDKTNSEAITNMTPRRKNHSQSQKSMTSSPLKNVLPDLK 640
Query: 600 --GEYNGERDSITSIV-TYDSAFSDISSSGNILSQ--HKGSSNIFMESAPTLKRKLNVND 654
N R+ SI +YDS S S + +++ K + + +PTLK K +
Sbjct: 641 ESSPLNDSREDTESITYSYDSELSSSSPPRDTVTKKSRKVRNIVNNTDSPTLKTKTGFLN 700
Query: 655 LRRFNFEKSDSTDDRSCSPQNREATETSATSMESDANDNAIQDEYENENEDIASLITAYE 714
LR F FE + S D++ + E + + ES+ D + D +S Y+
Sbjct: 701 LREFTFEDTKSLDEKKSTIDGLEKNYDNKENQESEYESTKKLDN----SLDASSEANNYD 756
Query: 715 ESTSEIDTQCQNNAQ--IRRPTSGRISITRNYSVASPNSLRSILPKSPLILGNEVFIERD 772
+T + + C + + + RP SGRISI+R S+A I P L + V E++
Sbjct: 757 ITTRKKHSSCNHKIKQAVVRPASGRISISRVQSIA-------ITPTKELSI---VDPEQN 806
Query: 773 KALAANQDIIXXXXXXXXXXXNDNDRKFTVSRGSVCNDSDSQSISTNLLFSSAQASPQKL 832
K+ + ++I N ++ + +V SIST+ LF SAQ SP K
Sbjct: 807 KSNSVIEEI--SEIEPLNLEYNKKSALYSDTSSTVI------SISTSKLFESAQNSPLK- 857
Query: 833 VIKEVDVIQEKSEHPDVPTPVLCKQPIS-KLSETPSIKSIGSR-------DSEESFDLTS 884
Q ++ + P + +LS P+I+S+ S + E+F+ +
Sbjct: 858 --------QTQNPQREFPNGTSVSETNRIRLSIAPTIESVVSDLNSITTGSTVETFETSR 909
Query: 885 IASKPNRAQSTTLREKYH------------LEKQATNDIFEEDVENLNP----ENNKYLF 928
P++ + LRE+Y L + T D+ + + + +P +NNKY F
Sbjct: 910 DLPVPHQ-RIINLREEYQRGNQDIISNTSSLHELKTIDLSDSNNDLESPSTHAKNNKYFF 968
Query: 929 SPDTDSIDFASPEKNLDDLKQQFIDQSTDEQTSLDEEEIATQDNENKDHG---------- 978
SPD SID ASP KN+++LK +F+ ++ +++ + D + D
Sbjct: 969 SPDDGSIDVASPMKNVEELKSKFLKNESETNSNISGSVLTMDDIDINDTSSARNTRRANS 1028
Query: 979 -------IDKKKLEDIMNGIDDTADTSMDPVNLALMKLEGTYDK-GEKEIDDKSPSI--- 1027
++KK L +I N +DD+ + DP+ +ALMKLEGTY+K EK + KS
Sbjct: 1029 ESAFTGSLNKKNLNEIANMLDDSIND--DPITVALMKLEGTYEKIPEKPENTKSSDAIGI 1086
Query: 1028 -NSELAREVENFQIVQTAALPES-ARKRQSMFIQRRRNTMIDFSVRDSLIDKD----SSC 1081
S+LA EVE + + S A KR+S+ I+RRR T+++ +K+ SS
Sbjct: 1087 KTSKLADEVEMLNLNNLPSFQNSPAEKRKSLLIERRRQTIMNIPFTPDQSEKEGFTSSSP 1146
Query: 1082 TRLE---NTD-----EQIRNLLNQYTLTDSRLKIDNLEQHIPFILMYDSKSVANQLTLIE 1133
+++ N D QI+ L+ QY + DSRL I N E H+PFILMYDS SVA Q+TLIE
Sbjct: 1147 EKIDVSANVDVAVQAAQIQELIGQYRIHDSRLMISNNESHVPFILMYDSLSVAQQMTLIE 1206
Query: 1134 KEILSEVDWKDLLDLTMSEQLPQFTSWLQLLVQNENLSGIDLAIARFNLTVDWIISEIVM 1193
KEIL E+DWKDLLDL M + PQ SWLQLLV+NE LSGIDLAI+RFNLTVDWIISEI++
Sbjct: 1207 KEILGEIDWKDLLDLKMKHEGPQVISWLQLLVRNETLSGIDLAISRFNLTVDWIISEILL 1266
Query: 1194 TQDIRLRRNTIQRFIHIAEHCKELQNYNTLMEIILALNSIVVQKFTETWRLVEPGDLLTW 1253
T+ +++RN IQRFIH+A+HC+ QN+NTLMEIILAL+S VVQKFT+ WRL+EPGDLLTW
Sbjct: 1267 TKSSKMKRNVIQRFIHVADHCRTFQNFNTLMEIILALSSSVVQKFTDAWRLIEPGDLLTW 1326
Query: 1254 ETLKAIPSLEKNYSNIRQLIDEVEPLSGCIPFIVVYLSDLSLNIEKRTWIVHDEVLNYNK 1313
E LK IPSL++NYS IR L++ V PL GC+PFIVVYLSDLS N EK+ WI+ D+V+NYNK
Sbjct: 1327 EELKKIPSLDRNYSTIRNLLNSVNPLVGCVPFIVVYLSDLSANAEKKDWILEDKVVNYNK 1386
Query: 1314 FQTNVQIVKNFVQKMQWSKFYNIDIDHELLSKCVYITSLSHDEINSIS 1361
F TNVQIVKNF+Q++QWSKFY ++HELLSKCVYI++L+ +EIN +S
Sbjct: 1387 FDTNVQIVKNFIQRVQWSKFYTFKVNHELLSKCVYISTLTQEEINELS 1434
>SPBC336.03 [T] KOG3417 Ras1 guanine nucleotide exchange factor
Length = 987
Score = 89.0 bits (219), Expect = 5e-17
Identities = 64/237 (27%), Positives = 114/237 (48%), Gaps = 20/237 (8%)
Query: 1117 ILMYDSKSVANQLTLIEKEILSEVDWKDLLDLTMSEQLPQFTSWLQLLVQNENLSGIDLA 1176
+ Y + A+Q+TL+E + L ++ ++ + F SW V ++ S +
Sbjct: 748 VYAYTPEEFASQMTLLEFDYLKQIPSREWI----------FRSW----VSRDSRSAVRNY 793
Query: 1177 IARFNLTVDWIISEIVMTQDIRLRRNTIQRFIHIAEHCKELQNYNTLMEIILALNSIVVQ 1236
I N WII+ I+ ++ + R I FI A C LQN++TLM I+ ALNS +
Sbjct: 794 INFSNCFTYWIINCILEKKNTKARTAVISFFIQTAYKCLSLQNFSTLMSIVSALNSAPIY 853
Query: 1237 KFTETWRLVEPGDLLTWETLKAIPSLEKNYSNIRQLIDEVEPLSGCIPFIVVYLSDLSLN 1296
+ ++LV+ D++ L+ I +KN+S R L+ + E C+PF+ V LSDL+
Sbjct: 854 RLHAAYKLVKAEDIICLSGLREIVETKKNFSTYRALLRKAE--LPCVPFLGVILSDLTFI 911
Query: 1297 IEKRTWIVHD--EVLNYNKFQTNVQIVKNF--VQKMQWSKFYNIDIDHELLSKCVYI 1349
E ++ +L++NK +V + Q + N D+ +L +C ++
Sbjct: 912 DEGNPDVLDSSPHLLSFNKRHRLADVVADVCRFQSSSYEMQSNTDLQSYILHRCRFV 968
>Hs19923151 [T] KOG3417 Ras1 guanine nucleotide exchange factor
Length = 1275
Score = 87.8 bits (216), Expect = 1e-16
Identities = 96/468 (20%), Positives = 187/468 (39%), Gaps = 57/468 (12%)
Query: 892 AQSTTLREKYHLEKQATNDIFEEDVENLNPENNKYLFSPDTDSIDFASPEKNLDDLKQQF 951
+++T K ++ TN I +E + PE + D ++ S E ++ +
Sbjct: 795 SKATLDTSKLYVSSSFTNKIPDEG--DTTPEKPE-----DPSALSKQSSEVSMREESDID 847
Query: 952 IDQSTDEQTSLDEEEIATQDNENKDHGIDKKKLEDIMNGIDDTADTSMDPVNLALMKLEG 1011
+QS D T + T K+ + L NG+ T+ +D N + +
Sbjct: 848 QNQSDDGDTETSPTKSPTTPKSVKNKNSSEFPLFSYNNGVVMTSCRELDN-NRSALSAAS 906
Query: 1012 TYDKGEKEIDDKSPSINSELAREVENFQIVQTAALPESARKRQSMFIQRRRNT------- 1064
+ ++ +P N E R + + +A P R F+ RR T
Sbjct: 907 AFAIATAGANEGTP--NKEKYRRMS----LASAGFPPDQRNGDKEFVIRRAATNRVLNVL 960
Query: 1065 -------MIDFSVRDSLIDK-----------DSSCTRLENTDEQIRNLLNQYTLTDSRLK 1106
DF D L K T+ I L Q D+++
Sbjct: 961 RHWVSKHSQDFETNDELKCKVIGFLEEVMHDPELLTQERKAAANIIRTLTQEDPGDNQIT 1020
Query: 1107 IDNLEQHIPFILM-----YDSKSVANQLTLIEKEILSEVDWKDLLDLTMSEQLPQFTSWL 1161
++ + Q + + + +A QLTL++ + ++ +++ W+
Sbjct: 1021 LEEITQMAEGVKAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFG----------QGWM 1070
Query: 1162 QLLVQNENLSGIDLAIARFNLTVDWIISEIVMTQDIRLRRNTIQRFIHIAEHCKELQNYN 1221
+L +NE I FN + I SEI+ +DI R + I++++ +A+ C+ L NYN
Sbjct: 1071 KL-EKNERTPYIMKTTKHFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYN 1129
Query: 1222 TLMEIILALNSIVVQKFTETWRLVEPGDLLTWETLKAIPSLEKNYSNIRQLIDEVEPLSG 1281
++EI ++N + + +TW V + L+ + S E + N+R+ + +P
Sbjct: 1130 AVLEITSSMNRSAIFRLKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDP--P 1187
Query: 1282 CIPFIVVYLSDLSLNIEKRTWIVHDEVLNYNKFQTNVQIVKNFVQKMQ 1329
C+P++ +YL+DL+ E D ++N++K + I++ Q Q
Sbjct: 1188 CVPYLGMYLTDLAFIEEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQ 1235
>YLR310c [T] KOG3417 Ras1 guanine nucleotide exchange factor
Length = 1589
Score = 84.3 bits (207), Expect = 1e-15
Identities = 61/213 (28%), Positives = 105/213 (48%), Gaps = 17/213 (7%)
Query: 1117 ILMYDSKSVANQLTLIEKEILSEVDWKDLLDLTMSEQLPQFTSWLQLLVQNENLSGIDLA 1176
+L D + A QLT++E ++ L +TM E L + +W I
Sbjct: 1301 LLDIDPYTYATQLTVLEHDLY--------LRITMFECLDR--AWGTKYCNMGGSPNITKF 1350
Query: 1177 IARFNLTVDWIISEIVMTQDIRLRRNTIQRFIHIAEHCKELQNYNTLMEIILALNSIVVQ 1236
IA N +++ IV D++ R Q F+ +A+HCKEL N++++ I+ AL S +
Sbjct: 1351 IANANTLTNFVSHTIVKQADVKTRSKLTQYFVTVAQHCKELNNFSSMTAIVSALYSSPIY 1410
Query: 1237 KFTETWRLV--EPGDLLTWETLKAIPSLEKNYSNIRQLIDEVEPLSGCIPFIVVYLSDLS 1294
+ +TW LV E DLL + L + ++N+ R+L+ V ++ C+PF VYLSDL+
Sbjct: 1411 RLKKTWDLVSTESKDLL--KNLNNLMDSKRNFVKYRELLRSVTDVA-CVPFFGVYLSDLT 1467
Query: 1295 LNIEKRTWIVHD--EVLNYNKFQTNVQIVKNFV 1325
+H+ ++N++K IV+ +
Sbjct: 1468 FTFVGNPDFLHNSTNIINFSKRTKIANIVEEII 1500
>Hs8922307 [T] KOG3417 Ras1 guanine nucleotide exchange factor
Length = 279
Score = 81.6 bits (200), Expect = 8e-15
Identities = 43/132 (32%), Positives = 73/132 (54%), Gaps = 4/132 (3%)
Query: 1166 QNENLSGIDLAIA---RFNLTVDWIISEIVMTQDIRLRRNTIQRFIHIAEHCKELQNYNT 1222
+ E S A+A RFN W++ EI+ Q +++R + +I A+ EL N +
Sbjct: 80 KKEKYSSAPNAVAFTRRFNHVSFWVVREILHAQTLKIRAEVLSHYIKTAKKLYELNNLHA 139
Query: 1223 LMEIILALNSIVVQKFTETWRLVEPGDLLTWETLKAIPSLEKNYSNIRQLIDEVEPLSGC 1282
LM ++ L S + + T+TW L+ D T+E L+ + S E NY +R I ++ ++ C
Sbjct: 140 LMAVVSGLQSAPIFRLTKTWALLSRKDKTTFEKLEYVMSKEDNYKRLRDYISSLK-MTPC 198
Query: 1283 IPFIVVYLSDLS 1294
IP++ +YLSDL+
Sbjct: 199 IPYLGIYLSDLT 210
>Hs20546742 [T] KOG3417 Ras1 guanine nucleotide exchange factor
Length = 1237
Score = 81.3 bits (199), Expect = 1e-14
Identities = 63/252 (25%), Positives = 119/252 (47%), Gaps = 20/252 (7%)
Query: 1091 IRNLLNQYTLTDSRLKIDNLEQHIPFILM--YDSKS---VANQLTLIEKEILSEVDWKDL 1145
I L+Q D LK++++ Q + ++S S +A Q+TL++ I + +++
Sbjct: 967 ILRALSQDDQDDIHLKLEDIIQMTDCMKAECFESLSAMELAEQITLLDHVIFRSIPYEEF 1026
Query: 1146 LDLTMSEQLPQFTSWLQLLVQNENLSGIDLAIARFNLTVDWIISEIVMTQDIRLRRNTIQ 1205
L W++L +NE I FN + + S+I+ D+ R N I+
Sbjct: 1027 LG----------QGWMKL-DKNERTPYIMKTSQHFNDMSNLVASQIMNYADVSSRANAIE 1075
Query: 1206 RFIHIAEHCKELQNYNTLMEIILALNSIVVQKFTETWRLVEPGDLLTWETLKAIPSLEKN 1265
+++ +A+ C+ L NYN ++EI ALN + + +TW V + L+ S E
Sbjct: 1076 KWVAVADICRCLHNYNGVLEITSALNRSAIYRLKKTWAKVSKQTKALMDKLQKTVSSEGR 1135
Query: 1266 YSNIRQLIDEVEPLSGCIPFIVVYLSDLSLNIEKRTWIVHDEVLNYNKFQTNVQIVKNFV 1325
+ N+R+ + P +P++ +YL+DL+ E + ++N++K + I++
Sbjct: 1136 FKNLRETLKNCNP--PAVPYLGMYLTDLAFIEEGTPNFTEEGLVNFSKMRMISHIIREIR 1193
Query: 1326 QKMQWSKFYNID 1337
Q Q S Y ID
Sbjct: 1194 QFQQTS--YRID 1203
>Hs7662070 [T] KOG3417 Ras1 guanine nucleotide exchange factor
Length = 557
Score = 77.8 bits (190), Expect = 1e-13
Identities = 48/178 (26%), Positives = 90/178 (49%), Gaps = 14/178 (7%)
Query: 1117 ILMYDSKSVANQLTLIEKEILSEVDWKDLLDLTMSEQLPQFTSWLQLLVQNENLSGIDLA 1176
+L + A+Q+TL++ + + ++L S++ + +L+ +A
Sbjct: 46 VLKVTPEEFASQITLMDIPVFKAIQPEELASCGWSKK------------EKHSLAPNVVA 93
Query: 1177 IAR-FNLTVDWIISEIVMTQDIRLRRNTIQRFIHIAEHCKELQNYNTLMEIILALNSIVV 1235
R FN W++ EI+ Q +++R + F+ IA+ EL N ++LM ++ AL S +
Sbjct: 94 FTRRFNQVSFWVVREILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPI 153
Query: 1236 QKFTETWRLVEPGDLLTWETLKAIPSLEKNYSNIRQLIDEVEPLSGCIPFIVVYLSDL 1293
+ T+TW L+ D T+E L + S E NY R+ I ++ + IP++ +YL DL
Sbjct: 154 FRLTKTWALLNRKDKTTFEKLDYLMSKEDNYKRTREYIRSLKMVPS-IPYLGIYLLDL 210
>SPCC1442.01 [T] KOG3417 Ras1 guanine nucleotide exchange factor
Length = 911
Score = 77.0 bits (188), Expect = 2e-13
Identities = 64/250 (25%), Positives = 117/250 (46%), Gaps = 31/250 (12%)
Query: 1117 ILMYDSKSVANQLTLIEKEILSEVDWKDLLDLTMSEQLPQFTSWLQLLVQNENLSGIDLA 1176
+L+ + +A QL ++E + S + L + + L +F+ E S L+
Sbjct: 659 VLLLPPREIAKQLCILEFQSFSHISRIQFLT-KIWDNLNRFSP-------KEKTSTFYLS 710
Query: 1177 IARFNLTVDWIISEIVMTQDIRLRRNTIQRFIHIAEHCKELQNYNTLMEIILALNSIVVQ 1236
N V+++ IV ++ R R N + FI + ++ +EL N+ +L II ALNS +
Sbjct: 711 ----NHLVNFVTETIVQEEEPRRRTNVLAYFIQVCDYLRELNNFASLFSIISALNSSPIH 766
Query: 1237 KFTETWRLVEPGDLLTWETLKAIPSLEKNYSNIRQLIDEVEPLSGCIPFIVVYLSDLS-- 1294
+ +TW + L ++E L + KN+SN R ++ + C+PF+ VY +DL+
Sbjct: 767 RLRKTWANLNSKTLASFELLNNLTEARKNFSNYRDCLENC--VLPCVPFLGVYFTDLTFL 824
Query: 1295 -----------LNIEKRTWIVHDEVLNYNKFQTNVQIVKNFVQKMQWSKFYNIDIDHELL 1343
+N +KRT + +LN K +V + N + ++Q + N I E
Sbjct: 825 KTGNKDNFQNMINFDKRTKVT--RILNEIKKFQSVGYMFNPINEVQ--ELLNEVISRERN 880
Query: 1344 SKCVYITSLS 1353
+ +Y SL+
Sbjct: 881 TNNIYQRSLT 890
>Hs5901914 [T] KOG2378 cAMP-regulated guanine nucleotide exchange factor
Length = 1011
Score = 75.5 bits (184), Expect = 5e-13
Identities = 49/198 (24%), Positives = 99/198 (49%), Gaps = 16/198 (8%)
Query: 1119 MYDSKSVANQLTLIEKEILSEVDWKDLLDLTMSEQLPQFTSWLQLLVQNENLSGIDLAIA 1178
+ SK +A Q+T+ + E+ + V +L+ T + T+ + +DL +
Sbjct: 770 LMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFKKTT-----------ANLDLFLR 818
Query: 1179 RFNLTVDWIISEIVMTQDIRLRRNTIQRFIHIAEHCKELQNYNTLMEIILALNSIVVQKF 1238
RFN W+++EI + + R +++FI IA HCKE +N N+ I++ L++I V +
Sbjct: 819 RFNEIQFWVVTEICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNIAVSRL 878
Query: 1239 TETWRLVEPGDLLTWETLKAIPSLEKNYSNIRQLIDEVEPLSGCIPFIVVYLSDLSLNIE 1298
TW + + +++ +N+ R + ++EP IPF+ + + D++ E
Sbjct: 879 ALTWEKLPSKFKKFYAEFESLMDPSRNHRAYRLTVAKLEP--PLIPFMPLLIKDMTFTHE 936
Query: 1299 -KRTWIVHDEVLNYNKFQ 1315
+T+I D ++N+ K +
Sbjct: 937 GNKTFI--DNLVNFEKMR 952
>7302879 [T] KOG3417 Ras1 guanine nucleotide exchange factor
Length = 702
Score = 73.6 bits (179), Expect = 2e-12
Identities = 61/253 (24%), Positives = 119/253 (46%), Gaps = 25/253 (9%)
Query: 1107 IDNLEQHIPFILMYDSKSVANQLTLIEKEILSEVDWKDLLDLTMSEQLPQFTSWLQLLVQ 1166
I L+ I L + +ANQ+TL++ + +++ +L +++ +
Sbjct: 152 IKQLDAVILSALRVPADVLANQITLLDFPVFAQIQPDELSSCAWTKK-----------DK 200
Query: 1167 NENLSGIDLAIARFNLTVDWIISEIVMTQDIRLRRNTIQRFIHIAEHCKELQNYNTLMEI 1226
+ N I RFN T W + EI+ + + R I FI +A+ EL N ++L I
Sbjct: 201 HVNTPNIVAFTKRFNHTSFWTVQEILNAEQPKQRAEIITHFIKVAKKLHELNNLHSLFAI 260
Query: 1227 ILALNSIVVQKFTETWRLVEPGDLLTWETLKAIPSLEKNYSNIRQLIDEVEPLSGCIPFI 1286
I A+ S + + T+TW + D ++ L I S + N++N+R ++ + CIP++
Sbjct: 261 ISAMQSASIYRLTKTWACLSKKDRNAFDRLSDIFSDQDNWANLRSYLESLR--LPCIPYL 318
Query: 1287 VVYLSDL---SLNIEKRTWIVHDEVLNYNKFQTNVQIVKNFVQKMQWSKFYNIDIDHELL 1343
++L+DL L + + ++ NK ++++ N+ Q S + ++ HE
Sbjct: 319 GLFLTDLIYIDLAHPHKGGLEPEQ--RRNKMNNILRVISNY----QQSNYKHLQ-KHEAT 371
Query: 1344 SKCVYITSLSHDE 1356
K Y+TS+ + E
Sbjct: 372 QK--YLTSIRYIE 382
>7302878 [T] KOG3417 Ras1 guanine nucleotide exchange factor
Length = 665
Score = 73.6 bits (179), Expect = 2e-12
Identities = 61/253 (24%), Positives = 119/253 (46%), Gaps = 25/253 (9%)
Query: 1107 IDNLEQHIPFILMYDSKSVANQLTLIEKEILSEVDWKDLLDLTMSEQLPQFTSWLQLLVQ 1166
I L+ I L + +ANQ+TL++ + +++ +L +++ +
Sbjct: 152 IKQLDAVILSALRVPADVLANQITLLDFPVFAQIQPDELSSCAWTKK-----------DK 200
Query: 1167 NENLSGIDLAIARFNLTVDWIISEIVMTQDIRLRRNTIQRFIHIAEHCKELQNYNTLMEI 1226
+ N I RFN T W + EI+ + + R I FI +A+ EL N ++L I
Sbjct: 201 HVNTPNIVAFTKRFNHTSFWTVQEILNAEQPKQRAEIITHFIKVAKKLHELNNLHSLFAI 260
Query: 1227 ILALNSIVVQKFTETWRLVEPGDLLTWETLKAIPSLEKNYSNIRQLIDEVEPLSGCIPFI 1286
I A+ S + + T+TW + D ++ L I S + N++N+R ++ + CIP++
Sbjct: 261 ISAMQSASIYRLTKTWACLSKKDRNAFDRLSDIFSDQDNWANLRSYLESLR--LPCIPYL 318
Query: 1287 VVYLSDL---SLNIEKRTWIVHDEVLNYNKFQTNVQIVKNFVQKMQWSKFYNIDIDHELL 1343
++L+DL L + + ++ NK ++++ N+ Q S + ++ HE
Sbjct: 319 GLFLTDLIYIDLAHPHKGGLEPEQ--RRNKMNNILRVISNY----QQSNYKHLQ-KHEAT 371
Query: 1344 SKCVYITSLSHDE 1356
K Y+TS+ + E
Sbjct: 372 QK--YLTSIRYIE 382
>7302302 [T] KOG2378 cAMP-regulated guanine nucleotide exchange factor
Length = 957
Score = 72.8 bits (177), Expect = 4e-12
Identities = 37/152 (24%), Positives = 79/152 (51%), Gaps = 3/152 (1%)
Query: 1171 SGIDLAIARFNLTVDWIISEIVMTQDIRLRRNTIQRFIHIAEHCKELQNYNTLMEIILAL 1230
+ +D+ + RFN WI++E+V T + R +++FI +A +CKE QN N +++ L
Sbjct: 757 ANLDVFLRRFNEVQYWIVTELVSTPSLSKRVGLVRKFIKLAAYCKEYQNLNAFFAVVMGL 816
Query: 1231 NSIVVQKFTETWRLVEPGDLLTWETLKAIPSLEKNYSNIRQLIDEVEPLSGCIPFIVVYL 1290
+++ V + +TW + ++ +A+ +N+ R + +++P IPF+ + L
Sbjct: 817 SNMAVSRLQQTWEKIPSKFRKIFQEFEALIDPSRNHRAYRVFVGKLQP--PLIPFMPLLL 874
Query: 1291 SDLSLNIEKRTWIVHDEVLNYNKFQTNVQIVK 1322
D++ E + D ++N+ K Q ++
Sbjct: 875 KDMTFAHEGNKTSL-DGLVNFEKMHMMAQTMR 905
>CE23992 [T] KOG2378 cAMP-regulated guanine nucleotide exchange factor
Length = 1234
Score = 70.1 bits (170), Expect = 2e-11
Identities = 54/215 (25%), Positives = 101/215 (46%), Gaps = 16/215 (7%)
Query: 1113 HIPFILMYDSKSVANQLTLIEKEILSEVDWKDLLDLTMS-EQLPQFTSWLQLLVQNENLS 1171
H + + DS+ +A+QL L ++L D +LL + E P +
Sbjct: 983 HSSILHLIDSQELAHQLFLFHLQLLRSTDSNELLYQVIGRESFPLSMPF----------- 1031
Query: 1172 GIDLAIARFNLTVDWIISEIVMTQDIRLRRNTIQRFIHIAEHCKELQNYNTLMEIILALN 1231
+DL + RFN W +EI++ + R +++FI IA +E ++ T+ I L L+
Sbjct: 1032 NLDLLVRRFNEVQHWSTTEILLATEEN-RMEILKKFISIATIAREYRDLLTVFAITLGLS 1090
Query: 1232 SIVVQKFTETWRLVEPGDLLTWETLKAIPSLEKNYSNIRQLIDEVEPLSGCIPFIVVYLS 1291
+ + T TW + P L T+ L+ + +N+ R L+ ++ S IPF+ + L
Sbjct: 1091 HTSISRLTLTWSKLPPASLKTFSELENLLDPTRNHRMYRLLVSKMS--SPYIPFVPLILK 1148
Query: 1292 DLSLNIEKRTWIVHDEVLNYNKFQTNVQIVKNFVQ 1326
DL + I + ++ ++N+ K +I ++F Q
Sbjct: 1149 DL-MFIHQGNKSFYNGLVNFEKMHMFAKIFRSFRQ 1182
>Hs6912456 [T] KOG2378 cAMP-regulated guanine nucleotide exchange factor
Length = 580
Score = 67.0 bits (162), Expect = 2e-10
Identities = 46/187 (24%), Positives = 89/187 (46%), Gaps = 8/187 (4%)
Query: 1137 LSEVDWKDLLDLTMSEQLPQFTSWLQLLVQNENLSGIDLAIARFNLTVDWIISEIVMTQD 1196
L DW L + ++L FT Q E+ + + L + R N W+ +EI++
Sbjct: 353 LMNFDWS-LFNSIHEQELIYFTFSRQ--GSGEHTANLSLLLQRCNEVQLWVATEILLCSQ 409
Query: 1197 IRLRRNTIQRFIHIAEHCKELQNYNTLMEIILALNSIVVQKFTETWRLVEPGDLLTWETL 1256
+ R +++FI IA HCK +N N+ I++ LN+ V + ++TW + + L
Sbjct: 410 LGKRVQLVKKFIKIAAHCKAQRNLNSFFAIVMGLNTASVSRLSQTWEKIPGKFKKLFSEL 469
Query: 1257 KAIPSLEKNYSNIRQLIDEVEPLSGCIPFIVVYLSDLSLNIE-KRTWIVHDEVLNYNKFQ 1315
+++ N+ R +++P IPF+ + L D++ E +T++ D ++N+ K
Sbjct: 470 ESLTDPSLNHKAYRDAFKKMKPPK--IPFMPLLLKDVTFIHEGNKTFL--DNLVNFEKLH 525
Query: 1316 TNVQIVK 1322
V+
Sbjct: 526 MIADTVR 532
>CE28081 [T] KOG3542 cAMP-regulated guanine nucleotide exchange factor
Length = 1311
Score = 65.5 bits (158), Expect = 6e-10
Identities = 56/267 (20%), Positives = 117/267 (42%), Gaps = 29/267 (10%)
Query: 1072 DSLIDKDSSCTRLENTDEQIRNLLNQYTLTDSR--------LKIDNLEQHIPFILMYDSK 1123
D +I + ++EN E+I Y +SR L + L++ +L +++
Sbjct: 837 DGVIKQRRLPPQMENLAERIALNSRYYLKNNSRSEPLVPDELAPELLKEAQTQLLSLNAQ 896
Query: 1124 SVANQLTLIEKEILSEVDWKDLLD----LTMSEQLPQFTSWLQLLVQNENLSGIDLAIAR 1179
VA QLTL + + S ++ + LD L P+ + QL
Sbjct: 897 VVAAQLTLQDFSVFSAIEPTEFLDNLFKLDSKYGSPKLEEFEQL---------------- 940
Query: 1180 FNLTVDWIISEIVMTQDIRLRRNTIQRFIHIAEHCKELQNYNTLMEIILALNSIVVQKFT 1239
FN + W+ +EI + ++ R I++FI +A +C++L+N+N++ I+ L+ V++
Sbjct: 941 FNREMWWVATEICTERHVQKRAKLIKKFIKVARYCRDLRNFNSMFAIMSGLDKPAVRRLH 1000
Query: 1240 ETWRLVEPGDLLTWETLKAIPSLEKNYSNIRQLIDEVEPLSGCIPFIVVYLSDLSLNIEK 1299
+W V + + + + +N S RQ + EV +P V DL+ +
Sbjct: 1001 SSWERVSSKYIRMLDEIHQLVDPSRNMSKYRQHLAEVAQEPPVVPIYPVIKKDLTFAHDG 1060
Query: 1300 RTWIVHDEVLNYNKFQTNVQIVKNFVQ 1326
++++N+ K + + ++ ++
Sbjct: 1061 NA-TYSEKLINFEKLRLIAKSIRGVMK 1086
>CE28080 [T] KOG3542 cAMP-regulated guanine nucleotide exchange factor
Length = 1470
Score = 65.5 bits (158), Expect = 6e-10
Identities = 56/267 (20%), Positives = 117/267 (42%), Gaps = 29/267 (10%)
Query: 1072 DSLIDKDSSCTRLENTDEQIRNLLNQYTLTDSR--------LKIDNLEQHIPFILMYDSK 1123
D +I + ++EN E+I Y +SR L + L++ +L +++
Sbjct: 837 DGVIKQRRLPPQMENLAERIALNSRYYLKNNSRSEPLVPDELAPELLKEAQTQLLSLNAQ 896
Query: 1124 SVANQLTLIEKEILSEVDWKDLLD----LTMSEQLPQFTSWLQLLVQNENLSGIDLAIAR 1179
VA QLTL + + S ++ + LD L P+ + QL
Sbjct: 897 VVAAQLTLQDFSVFSAIEPTEFLDNLFKLDSKYGSPKLEEFEQL---------------- 940
Query: 1180 FNLTVDWIISEIVMTQDIRLRRNTIQRFIHIAEHCKELQNYNTLMEIILALNSIVVQKFT 1239
FN + W+ +EI + ++ R I++FI +A +C++L+N+N++ I+ L+ V++
Sbjct: 941 FNREMWWVATEICTERHVQKRAKLIKKFIKVARYCRDLRNFNSMFAIMSGLDKPAVRRLH 1000
Query: 1240 ETWRLVEPGDLLTWETLKAIPSLEKNYSNIRQLIDEVEPLSGCIPFIVVYLSDLSLNIEK 1299
+W V + + + + +N S RQ + EV +P V DL+ +
Sbjct: 1001 SSWERVSSKYIRMLDEIHQLVDPSRNMSKYRQHLAEVAQEPPVVPIYPVIKKDLTFAHDG 1060
Query: 1300 RTWIVHDEVLNYNKFQTNVQIVKNFVQ 1326
++++N+ K + + ++ ++
Sbjct: 1061 NA-TYSEKLINFEKLRLIAKSIRGVMK 1086
>CE07423 [T] KOG3541 Predicted guanine nucleotide exchange factor
Length = 596
Score = 63.2 bits (152), Expect = 3e-09
Identities = 64/250 (25%), Positives = 107/250 (42%), Gaps = 17/250 (6%)
Query: 1116 FILMYDSKSVANQLTLIEKEILSEVDWKDLLDLTMSEQLPQFTSWLQLLVQNENLSGIDL 1175
F+L D+K+VA QLT IE E S V +++ S+ L + + + +S I
Sbjct: 327 FVLCNDAKTVAQQLTHIEMERFSMVGVDEIVQSLASDPLSEIGRHSKN--KEGTISSISF 384
Query: 1176 AIARFNLTVDWIISEIVMTQDIRLRRNTIQRFIHIAEHCKELQNYNTLMEIILALNSIVV 1235
I FN + E++ R R + I IA+ C E+ N+N++M I+ L+ V
Sbjct: 385 YIEWFNRLSAFAAIEVLKQTKKRNRVAVFEFMIDIAKECCEIGNFNSMMAIVAGLSLPAV 444
Query: 1236 QKFTETWRLVEPGDLLTWETLKAIPSLEKNYSNIRQLIDEVEPLSG---------CIPFI 1286
+ +TW VE L E L+ N+ + R I + + IPF
Sbjct: 445 SRLKKTWCRVEKAKL---EILQHQLDPSGNFLSYRATIKAAQWRADSARGNQQKIVIPFF 501
Query: 1287 VVYLSDLSLNIEKRTWIVHDEVLNYNKFQTNVQIVKNFVQKMQWSKFYNIDIDHELLSKC 1346
V+ L DL L I+ + LN+ F Q+ + +QW + + +
Sbjct: 502 VLLLKDLFLIYHGHPRILPNAHLNFMAFN---QLAEQLRDVIQWKSTVCTFEKNPQVLQY 558
Query: 1347 VYITSLSHDE 1356
+ ITS+S ++
Sbjct: 559 LLITSVSGEK 568
>7297097 [T] KOG3542 cAMP-regulated guanine nucleotide exchange factor
Length = 1551
Score = 63.2 bits (152), Expect = 3e-09
Identities = 58/248 (23%), Positives = 115/248 (45%), Gaps = 17/248 (6%)
Query: 1078 DSSCTRLENTDEQIRNLLNQYTLTDSR-LKI-DNLEQHIPFILMYD--SKSVANQLTLIE 1133
D + +Q++NL + + LK+ D+ E +P L + +S + L L
Sbjct: 810 DGGMVKQRRLPDQLQNLAERISFAARYYLKLNDSTEPLVPDELALELVRESNVHFLHLNA 869
Query: 1134 KEILSEVDWKDLLDLTMSEQLPQFTSWLQLLVQNENLSGIDLAIARF----NLTVDWIIS 1189
E+ ++ +D + E T ++ L + + G+ + +++F N + W++S
Sbjct: 870 YELAIQLTLQDFANFRQIES----TEYVDELFELRSRYGVPM-LSKFAELVNREMFWVVS 924
Query: 1190 EIVMTQDIRLRRNTIQRFIHIAEHCKELQNYNTLMEIILALNSIVVQKFTETWRLVEPGD 1249
EI +I R +++FI IA HCKE +N+N++ I+ L V + +TW +
Sbjct: 925 EICAEHNIVRRMKIVKQFIKIARHCKECRNFNSMFAIVSGLGHGAVSRLRQTWEKLPSKY 984
Query: 1250 LLTWETLKAIPSLEKNYSNIRQLID-EVEPLSGCIPFIVVYLSDLS-LNIEKRTWIVHDE 1307
+ L+ + +N S RQL+ E+ IPF + DL+ +++ T + D
Sbjct: 985 QRLFNDLQDLMDPSRNMSKYRQLVSAELLAQHPIIPFYPIVKKDLTFIHLGNDTRV--DG 1042
Query: 1308 VLNYNKFQ 1315
++N+ K +
Sbjct: 1043 LINFEKLR 1050
>7290754 [T] KOG3417 Ras1 guanine nucleotide exchange factor
Length = 1380
Score = 61.6 bits (148), Expect = 8e-09
Identities = 49/209 (23%), Positives = 97/209 (45%), Gaps = 20/209 (9%)
Query: 1115 PFILMYDSKSVANQLTLIEKEILSEVDWKDLLDLTMSEQLPQFTSWLQLLVQNENLSGID 1174
P +L S +A Q+TL++ E+ ++++ ++L L +Q + + L ++
Sbjct: 1142 PSLLDLKSLEIAEQMTLLDAELFTKIEIPEVL-LFAKDQCEEKSPNLNKFTEH------- 1193
Query: 1175 LAIARFNLTVDWIISEIVMTQDIRLRRNTIQRFIHIAEHCKELQNYNTLMEIILALNSIV 1234
FN W S+I+ QD + R + +FI I +H +++ NYN+ + ++ AL+S
Sbjct: 1194 -----FNKMSYWARSKILRLQDAKEREKHVNKFIKIMKHLRKMNNYNSYLALLSALDSGP 1248
Query: 1235 VQKFTETWRLVEPGDLLTWETLKAIPSLEKNYSNIRQLIDEVEPLSGCIPFIVVYLSDLS 1294
+++ W + G + A+ ++ RQ + E P CIP+I + L DL+
Sbjct: 1249 IRRL--EW---QKGITEEVRSFCALIDSSSSFRAYRQALAETNP--PCIPYIGLILQDLT 1301
Query: 1295 LNIEKRTWIVHDEVLNYNKFQTNVQIVKN 1323
+ V+N++K I+ N
Sbjct: 1302 FVHVGNQDYLSKGVINFSKRWQQYNIIDN 1330
>Hs22046650 [T] KOG3629 Guanine-nucleotide releasing factor
Length = 1067
Score = 61.2 bits (147), Expect = 1e-08
Identities = 54/278 (19%), Positives = 115/278 (40%), Gaps = 32/278 (11%)
Query: 1108 DNLEQHIPFILMYDSKSVANQLTLIEKEILSEVDWKDLLDLTMSEQLPQFTSWLQLLVQN 1167
+ L + P +L++ VA Q TL++ E+ +V L S++ + L ++
Sbjct: 503 NGLSEEKPHLLVFPPDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKGKEHLAPTIR- 561
Query: 1168 ENLSGIDLAIARFNLTVDWIISEIVMTQDIRL--RRNTIQRFIHIAEHCKELQNYNTLME 1225
+ +FN + +I+ + + + R ++ +I +A C+ L+N+++L
Sbjct: 562 -------ATVTQFNSVANCVITTCLGNRSTKAPDRARVVEHWIEVARECRILKNFSSLYA 614
Query: 1226 IILALNSIVVQKFTETWRLVEPGDLLTWETLKAIPSLEKNYSNIRQLI------------ 1273
I+ AL S + + +TW V ++ L I S E NYS R+L+
Sbjct: 615 ILSALQSNSIHRLKKTWEDVSRDSFRIFQKLSEIFSDENNYSLSRELLIKEGTSKFATLE 674
Query: 1274 ----------DEVEPLSGCIPFIVVYLSDLSLNIEKRTWIVHDEVLNYNKFQTNVQIVKN 1323
E + G +P++ +L+DL + ++ ++N+ K + +++
Sbjct: 675 MNPKRAQKRPKETGIIQGTVPYLGTFLTDLVMLDTAMKDYLYGRLINFEKRRKEFEVIAQ 734
Query: 1324 FVQKMQWSKFYNIDIDHELLSKCVYITSLSHDEINSIS 1361
Y+I D + + + LS E ++S
Sbjct: 735 IKLLQSACNNYSIAPDEQFGAWFRAVERLSETESYNLS 772
>Hs20149570 [T] KOG3417 Ras1 guanine nucleotide exchange factor
Length = 671
Score = 61.2 bits (147), Expect = 1e-08
Identities = 39/132 (29%), Positives = 62/132 (46%), Gaps = 11/132 (8%)
Query: 1177 IARFNLTVDWIISEIVMTQDIRLRRNTIQRFIHIAEHCKELQNYNTLMEIILALNSIVVQ 1236
I+ FN W+ I+ R I F+H+AE +LQN+NTLM ++ L+ +
Sbjct: 259 ISLFNSVSQWVQLMILSKPTAPQRALVITHFVHVAEKLLQLQNFNTLMAVVGGLSHSSIS 318
Query: 1237 KFTETWRLVEPGDLLTWETLKAIPSLEKNYSNIRQLIDEVEPLSGCI----PFIVVYLSD 1292
+ ET V P + WE L + + NY N R+ L+ C+ P + V+L D
Sbjct: 319 RLKETHSHVSPETIKLWEGLTELVTATGNYGNYRR------RLAACVGFRFPILGVHLKD 372
Query: 1293 L-SLNIEKRTWI 1303
L +L + W+
Sbjct: 373 LVALQLALPDWL 384
>Hs4885357 [T] KOG3417 Ras1 guanine nucleotide exchange factor
Length = 1077
Score = 59.3 bits (142), Expect = 4e-08
Identities = 47/176 (26%), Positives = 85/176 (47%), Gaps = 22/176 (12%)
Query: 1120 YDSKSVANQLTLIEKEILSEVDWKDLLDLTMSEQLPQFTSWLQLLVQNENLS-GIDLAIA 1178
+ S +A QLTL++ E+ +++ +P+ W + QNE S +
Sbjct: 839 FHSHEIAEQLTLLDAELFYKIE------------IPEVLLWAK--EQNEEKSPNLTQFTE 884
Query: 1179 RFNLTVDWIISEIVMTQDIRLRRNTIQRFIHIAEHCKELQNYNTLMEIILALNSIVVQKF 1238
FN W+ S I++ + + R + +FI I +H ++L N+N+ + I+ AL+S +++
Sbjct: 885 HFNNMSYWVRSIIMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRL 944
Query: 1239 TETWRLVEPGDLLTWETLKAIPSLEKNYSNIRQLIDEVEPLSGCIPFIVVYLSDLS 1294
W+ L + TL S + Y R + EVEP CIP++ + L DL+
Sbjct: 945 --EWQKQTSEGLAEYCTLIDSSSSFRAY---RAALSEVEP--PCIPYLGLILQDLT 993
>Hs4758532 [T] KOG3629 Guanine-nucleotide releasing factor
Length = 777
Score = 56.2 bits (134), Expect = 3e-07
Identities = 51/258 (19%), Positives = 108/258 (41%), Gaps = 40/258 (15%)
Query: 1117 ILMYDSKSVANQLTLIEKEILSEVDWKDLLDLTMSEQLPQFTSWLQLLVQNENLSGIDLA 1176
+L++ + +A QLTL++ E+ L+L S+ L + +
Sbjct: 239 VLVFLADHLAEQLTLLDAELF--------LNLIPSQCLGGLWGHRDRPGHSHLCPSVRAT 290
Query: 1177 IARFNLTVDWIISEI------------VMTQDIR--LRRNTIQRFIHIAEHCKELQNYNT 1222
+ +FN ++S + V + +R R ++++I +AE C+ L+N+++
Sbjct: 291 VTQFNKVAGAVVSSVLGATSTGEGPGEVTIRPLRPPQRARLLEKWIRVAEECRLLRNFSS 350
Query: 1223 LMEIILALNSIVVQKFTETWRLVEPGDLLTWETLKAIPSLEKNYSNIRQLI-------DE 1275
+ ++ AL S + + W L + +L I S E NYS R+L+
Sbjct: 351 VYAVVSALQSSPIHRLRAAWGEATRDSLRVFSSLCQIFSEEDNYSQSRELLVQEVKLQSP 410
Query: 1276 VEPLS-----------GCIPFIVVYLSDLSLNIEKRTWIVHDEVLNYNKFQTNVQIVKNF 1324
+EP S G +P++ +L DL + + + +N++K + ++
Sbjct: 411 LEPHSKKAPRSGSRGGGVVPYLGTFLKDLVMLDAASKDELENGYINFDKRRKEFAVLSEL 470
Query: 1325 VQKMQWSKFYNIDIDHEL 1342
+ + YN+ DH++
Sbjct: 471 RRLQNECRGYNLQPDHDI 488
>CE05713 [T] KOG3417 Ras1 guanine nucleotide exchange factor
Length = 638
Score = 55.8 bits (133), Expect = 4e-07
Identities = 49/215 (22%), Positives = 100/215 (45%), Gaps = 21/215 (9%)
Query: 1137 LSEVDWKDLLDLTMSEQLPQFTSWLQLLVQNENLSG---IDLAIARFNLTVDWIISEIVM 1193
LS +D++ L ++++E L+ V++ +L ++ +I+ FN +W+ I+
Sbjct: 190 LSHIDYRVLSRISITE--------LKQYVKDGHLRSCPMLERSISVFNNLSNWVQCMILN 241
Query: 1194 TQDIRLRRNTIQRFIHIAEHCKELQNYNTLMEIILALNSIVVQKFTETWRLVEPGDLLTW 1253
+ R + +F+H+A+H +++ N+NTLM ++ + V + +T+ ++
Sbjct: 242 KTTPKERAEILVKFVHVAKHLRKINNFNTLMSVVGGITHSSVARLAKTYAVLSNDIKKEL 301
Query: 1254 ETLKAIPSLEKNYSNIRQLIDEVEPLSGCIPFIVVYLSDL------SLNIEKRTWIVHDE 1307
L + S + N+ R+ + IP I V+L DL N EK I D+
Sbjct: 302 TQLTNLLSAQHNFCEYRKALGACNK-KFRIPIIGVHLKDLVAINCSGANFEKTKCISSDK 360
Query: 1308 VLNYNKFQTNVQIVKNFVQKMQWSKFYNIDIDHEL 1342
++ +K +N + F QK N+D+ + L
Sbjct: 361 LVKLSKLLSNFLV---FNQKGHNLPEMNMDLINTL 392
>Hs7662334 [T] KOG3417 Ras1 guanine nucleotide exchange factor
Length = 689
Score = 55.1 bits (131), Expect = 8e-07
Identities = 35/139 (25%), Positives = 65/139 (46%), Gaps = 4/139 (2%)
Query: 1157 FTSWLQLLVQN--ENLSGIDLAIARFNLTVDWIISEIVMTQDIRLRRNTIQRFIHIAEHC 1214
FT + ++ EN ++ +IA FN W+ ++ + R I +FI++A+
Sbjct: 173 FTDYQSYVIHGCLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKL 232
Query: 1215 KELQNYNTLMEIILALNSIVVQKFTETWRLVEPGDLLTWETLKAIPSLEKNYSNIRQLID 1274
+L+N+NTLM ++ L+ + + ET + W + + S NY N R+
Sbjct: 233 LQLKNFNTLMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFA 292
Query: 1275 EVEPLSGCIPFIVVYLSDL 1293
+ + IP + V+L DL
Sbjct: 293 DCDGFK--IPILGVHLKDL 309
>Hs20127536 [T] KOG3629 Guanine-nucleotide releasing factor
Length = 803
Score = 55.1 bits (131), Expect = 8e-07
Identities = 47/229 (20%), Positives = 103/229 (44%), Gaps = 41/229 (17%)
Query: 1125 VANQLTLIEKEILSEVDWKDLLDLTMSEQLPQFTSWLQLLVQNENLSG-IDLAIARFNLT 1183
VA QLT ++ ++ +V L S + + +N++L+ I I++FN
Sbjct: 271 VAEQLTYMDAQLFKKVVPHHCLGCIWSRRDKK---------ENKHLAPTIRATISQFNTL 321
Query: 1184 VDWIISEIVMTQDIRL--RRNTIQRFIHIAEHCKELQNYNTLMEIILALNSIVVQKFTET 1241
++S I+ ++++ R I+++I+IA C+ L+N+++L I+ AL S + + +T
Sbjct: 322 TKCVVSTILGGKELKTQQRAKIIEKWINIAHECRLLKNFSSLRAIVSALQSNSIYRLKKT 381
Query: 1242 WRLVEPGDLLTWETLKAIPSLEKNYSNIRQLI---------------------------- 1273
W V +L +E L I S N+ R+L+
Sbjct: 382 WAAVPRDRMLMFEELSDIFSDHNNHLTSRELLMKEGTSKFANLDSSVKENQKRTQRRLQL 441
Query: 1274 -DEVEPLSGCIPFIVVYLSDLSLNIEKRTWIVHDEVLNYNKFQTNVQIV 1321
++ + G +P++ +L+DL++ + ++N+ K + +++
Sbjct: 442 QKDMGVMQGTVPYLGTFLTDLTMLDTALQDYIEGGLINFEKRRREFEVI 490
>Hs7705939 [T] KOG2378 cAMP-regulated guanine nucleotide exchange factor
Length = 456
Score = 54.7 bits (130), Expect = 1e-06
Identities = 45/203 (22%), Positives = 95/203 (46%), Gaps = 16/203 (7%)
Query: 1121 DSKSVANQLTLIEKEILSEVDWKDLLDLTM-SEQLPQFTSWLQLLVQNENLSGIDLAIAR 1179
+ + VAN LT E+ V + +D E+ + T+ L+LL+Q R
Sbjct: 218 EPEDVANHLTAFHWELFRCVHELEFVDYVFHGERGRRETANLELLLQ------------R 265
Query: 1180 FNLTVDWIISEIVMTQDIRLRRNTIQRFIHIAEHCKELQNYNTLMEIILALNSIVVQKFT 1239
+ W+ +E+++ + R +++FI IA CK+ Q+ + +++ L++ V +
Sbjct: 266 CSEVTHWVATEVLLCEAPGKRAQLLKKFIKIAALCKQNQDLLSFYAVVMGLDNAAVSRLR 325
Query: 1240 ETWRLVEPGDLLTWETLKAIPSLEKNYSNIRQLIDEVEPLSGCIPFIVVYLSDLSLNIEK 1299
TW + + + + +N+ + R++I +++P IPF+ + L DL+ E
Sbjct: 326 LTWEKLPGKFKNLFRKFENLTDPCRNHKSYREVISKMKP--PVIPFVPLILKDLTFLHEG 383
Query: 1300 RTWIVHDEVLNYNKFQTNVQIVK 1322
+V D ++N K + + V+
Sbjct: 384 SKTLV-DGLVNIEKLHSVAEKVR 405
>Hs7657261 [T] KOG3542 cAMP-regulated guanine nucleotide exchange factor
Length = 1499
Score = 54.3 bits (129), Expect = 1e-06
Identities = 51/225 (22%), Positives = 92/225 (40%), Gaps = 13/225 (5%)
Query: 1091 IRNLLNQYTLTDSRLKIDNLEQHIPFILMYDSKSVANQLTLIEKEILSEVDWKDLLDLTM 1150
++N + TL + L + +L + VA QL++ E+ ++ + +D
Sbjct: 687 LKNNMETETLCSDEDAQELLRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLF 746
Query: 1151 SEQLPQFTSWLQLLVQNENLSGIDLAIARFNLTVDWIISEIVMTQDIRLRRNTIQRFIHI 1210
L+ NL + I N W+ SEI+ + R I+ FI I
Sbjct: 747 K---------LRSKTSCANLKRFEEVI---NQETFWVASEILRETNQLKRMKIIKHFIKI 794
Query: 1211 AEHCKELQNYNTLMEIILALNSIVVQKFTETWRLVEPGDLLTWETLKAIPSLEKNYSNIR 1270
A HC+E +N+N++ II LN V + TW + ++ L+ + +N + R
Sbjct: 795 ALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYEKLFQDLQDLFDPSRNMAKYR 854
Query: 1271 QLIDEVEPLSGCIPFIVVYLSDLSLNIEKRTWIVHDEVLNYNKFQ 1315
+++ IP V DL+ E V D ++N+ K +
Sbjct: 855 NVLNSQNLQPPIIPLFPVIKKDLTFLHEGNDSKV-DGLVNFEKLR 898
>Hs15529996 [T] KOG3417 Ras1 guanine nucleotide exchange factor
Length = 1333
Score = 53.1 bits (126), Expect = 3e-06
Identities = 48/205 (23%), Positives = 93/205 (44%), Gaps = 18/205 (8%)
Query: 1125 VANQLTLIEKEILSEVDWKDLLDLTMSEQLPQFTSWLQLLVQNENLSGIDLAIARFNLTV 1184
+A QLTL+E ++ V +L+ +++ + S NL + + NLT+
Sbjct: 784 IARQLTLLESDLYRAVQPSELVGSVWTKEDKEINS--------PNL--LKMIRHTTNLTL 833
Query: 1185 DWIISEIVMTQDIRLRRNTIQRFIHIAEHCKELQNYNTLMEIILALNSIVVQKFTETWRL 1244
W IV T+++ R + R I I + +EL N+N ++E++ A+NS V + T+
Sbjct: 834 -WFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQ 892
Query: 1245 VEPGDLLTWETLKAIPSLEKNYSNIRQLIDEVEPLSGCIPFIVVYLSDLSLNIEKRTWIV 1304
+ E +A E +Y + + P C+PF +YL+++ E ++
Sbjct: 893 IPSRQKKILE--EAHELSEDHYKKYLAKLRSINP--PCVPFFGIYLTNILKTEEGNPEVL 948
Query: 1305 H---DEVLNYNKFQTNVQIVKNFVQ 1326
E++N++K + +I Q
Sbjct: 949 KRHGKELINFSKRRKVAEITGEIQQ 973
>7302774 [T] KOG3541 Predicted guanine nucleotide exchange factor
Length = 704
Score = 52.4 bits (124), Expect = 5e-06
Identities = 70/310 (22%), Positives = 125/310 (39%), Gaps = 41/310 (13%)
Query: 1085 ENTDEQIRNLLNQYTLTDS---RLKIDNLEQHIPFILMYDSK--------SVANQLTLIE 1133
EN Q+ NLL + + S + I +L++ + D+ +A+QL IE
Sbjct: 383 ENGRSQLNNLLTKQSSASSLGRQSSIKSLKRFAANVYKTDNVLNNCSSAFELAHQLYAIE 442
Query: 1134 KEILSEVDWKDLLDLTMSEQLPQFTSWLQLLVQNENLSG---IDLAIARFNLTVDWIISE 1190
LS++ ++ +++ ++L S + N ID + FN +E
Sbjct: 443 YAYLSQIRLEEFVEILEKDELKTCISQTKAGTLGSNCISQVTIDSYVQWFNQLSYLTATE 502
Query: 1191 IVMTQDIRLRRNTIQRFIHIAEHCKELQNYNTLMEIILALNSIVVQKFTETWRLVEPGDL 1250
I+ R I ++ A C N+N+LM I+ ALN + + +TW V+
Sbjct: 503 ILKLGKKSQRAQMIDFWVETALECFNTGNFNSLMAILTALNLTAIARLKKTWAKVQ---T 559
Query: 1251 LTWETLKAIPSLEKNYSNI------------RQLIDEVEPLSGCIPFIVVYLSDLSLNIE 1298
+E L+ N+ N R++ +E+E IPF ++L DL E
Sbjct: 560 TKFEGLEHQMDPSSNFLNYRSTMKAAVWRSEREMANEIE--RAIIPFFSLFLKDLHAINE 617
Query: 1299 KRTWIVHDEVLNYNKFQTNVQIVKNFVQKMQWSKFYNIDIDHELLSKCV-YITS---LSH 1354
+ + +N+ K ++NF K+ +D +E L V Y+ LS
Sbjct: 618 SHETKLANGYINFEKCLHLGTQLRNF------GKWQRLDCPYEQLPSVVSYLLKAEVLSE 671
Query: 1355 DEINSISHKS 1364
D + S++S
Sbjct: 672 DLLMKASYES 681
>Hs7706513 [T] KOG3542 cAMP-regulated guanine nucleotide exchange factor
Length = 1204
Score = 52.0 bits (123), Expect = 6e-06
Identities = 36/141 (25%), Positives = 63/141 (44%), Gaps = 1/141 (0%)
Query: 1186 WIISEIVMTQDIRLRRNTIQRFIHIAEHCKELQNYNTLMEIILALNSIVVQKFTETWRLV 1245
W+ SEI+ + R I+ FI IA HC+E +N+N++ II LN V + TW +
Sbjct: 963 WVASEILTEANQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLASVARLRGTWEKL 1022
Query: 1246 EPGDLLTWETLKAIPSLEKNYSNIRQLIDEVEPLSGCIPFIVVYLSDLSLNIEKRTWIVH 1305
+ L+ I +N + R ++ IP V D++ E V
Sbjct: 1023 PSKYEKHLQDLQDIFDPSRNMAKYRNILSSQSMQPPIIPLFPVVKKDMTFLHEGNDSKV- 1081
Query: 1306 DEVLNYNKFQTNVQIVKNFVQ 1326
D ++N+ K + + ++ V+
Sbjct: 1082 DGLVNFEKLRMISKEIRQVVR 1102
>Hs5032025 [T] KOG3417 Ras1 guanine nucleotide exchange factor
Length = 797
Score = 52.0 bits (123), Expect = 6e-06
Identities = 69/308 (22%), Positives = 123/308 (39%), Gaps = 32/308 (10%)
Query: 1063 NTMIDFSVRDSLIDKDSSCTRLENTDEQIRNLLNQYTL-----TDSRLKIDNLEQHIPFI 1117
+TM +F ++ C ++ T R+ + T T + K+ L H+
Sbjct: 148 DTMEEFQELVKAKGEELHCRLIDTTQINARDWSRKLTQRIKSNTSKKRKVSLLFDHL--- 204
Query: 1118 LMYDSKSVANQLTLIEKEILSEVDWKDLLDLTMSEQLPQFTSWLQLLVQNENLSGIDLAI 1177
+ + ++ LT +E + + + D + ++L EN + ++ +I
Sbjct: 205 ---EPEELSEHLTYLEFKSFRRISFSD------------YQNYLVNSCVKENPT-MERSI 248
Query: 1178 ARFNLTVDWIISEIVMTQDIRLRRNTIQRFIHIAEHCKELQNYNTLMEIILALNSIVVQK 1237
A N W+ ++ +LR +FI +A+ +LQN+NTLM +I L + +
Sbjct: 249 ALCNGISQWVQLMVLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGGLCHSSISR 308
Query: 1238 FTETWRLVEPGDLLTWETLKAIPSLEKNYSNIRQLIDEVEPLSGCIPFIVVYLSDLSLNI 1297
ET V + + S +NY N R+ E IP + V+L DL
Sbjct: 309 LKETSSHVPHEINKVLGEMTELLSSSRNYDNYRRAYGECTDFK--IPILGVHLKDLISLY 366
Query: 1298 EKRTWIVHDEVLNYNKFQTNVQIVKNFVQKMQWSK--FYNIDIDHEL-LSKCVYITSLSH 1354
E + D +N +K + VQ + + N D+ H L LS +Y T
Sbjct: 367 EAMPDYLGDGKVNVHKLLALYNHISELVQLQEVAPPLEANKDLVHLLTLSLDLYYT---E 423
Query: 1355 DEINSISH 1362
DEI +S+
Sbjct: 424 DEIYELSY 431
>Hs20070215 [T] KOG2378 cAMP-regulated guanine nucleotide exchange factor
Length = 881
Score = 51.6 bits (122), Expect = 8e-06
Identities = 37/197 (18%), Positives = 88/197 (43%), Gaps = 13/197 (6%)
Query: 1119 MYDSKSVANQLTLIEKEILSEVDWKDLLDLTMSEQLPQFTSWLQLLVQNENLSGIDLAIA 1178
+ +K +A QLT + + + + +L+ + Q +++ + ++ +
Sbjct: 618 LVSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQH----------LRDVTTANLERFMR 667
Query: 1179 RFNLTVDWIISEIVMTQDIRLRRNTIQRFIHIAEHCKELQNYNTLMEIILALNSIVVQKF 1238
RFN W+ +E+ + R +++FI +A H KE +N N+ ++ L++ + +
Sbjct: 668 RFNELQYWVATELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRL 727
Query: 1239 TETWRLVEPGDLLTWETLKAIPSLEKNYSNIRQLIDEVEPLSGCIPFIVVYLSDLSLNIE 1298
TW + + L+ + N+ R + ++ P IPF+ + L D++ E
Sbjct: 728 AHTWERLPHKVRKLYSALERLLDPSWNHRVYRLALAKLSP--PVIPFMPLLLKDMTFIHE 785
Query: 1299 KRTWIVHDEVLNYNKFQ 1315
+V + ++N+ K +
Sbjct: 786 GNHTLV-ENLINFEKMR 801
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.313 0.130 0.359
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 79,481,833
Number of Sequences: 60738
Number of extensions: 3513468
Number of successful extensions: 11453
Number of sequences better than 1.0e-05: 33
Number of HSP's better than 0.0 without gapping: 18
Number of HSP's successfully gapped in prelim test: 15
Number of HSP's that attempted gapping in prelim test: 11373
Number of HSP's gapped (non-prelim): 64
length of query: 1366
length of database: 30,389,216
effective HSP length: 119
effective length of query: 1247
effective length of database: 23,161,394
effective search space: 28882258318
effective search space used: 28882258318
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)