ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactI1331 good IT KOG1435 Lipid transport and metabolism Sterol reductase/lamin B receptor
r_klactI1331 good IT KOG1435 Signal transduction mechanisms Sterol reductase/lamin B receptor
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactI1331 453730 452336 -465
(465 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YGL012w [IT] KOG1435 Sterol reductase/lamin B receptor 692 0.0
SPAC20G4.07c [IT] KOG1435 Sterol reductase/lamin B receptor 434 e-121
Hs4504961 [IT] KOG1435 Sterol reductase/lamin B receptor 181 3e-45
Hs20537133 [IT] KOG1435 Sterol reductase/lamin B receptor 181 3e-45
SPBC16G5.18 [IT] KOG1435 Sterol reductase/lamin B receptor 166 5e-41
YNL280c [IT] KOG1435 Sterol reductase/lamin B receptor 143 5e-34
At1g50430 [IT] KOG1435 Sterol reductase/lamin B receptor 121 2e-27
Hs4503321 [IT] KOG1435 Sterol reductase/lamin B receptor 119 1e-26
Hs4507547 [IT] KOG1435 Sterol reductase/lamin B receptor 115 1e-25
CE19655_2 [IT] KOG1435 Sterol reductase/lamin B receptor 72 1e-12
At3g52940 [IT] KOG1435 Sterol reductase/lamin B receptor 61 4e-09
>YGL012w [IT] KOG1435 Sterol reductase/lamin B receptor
Length = 473
Score = 692 bits (1787), Expect = 0.0
Identities = 317/460 (68%), Positives = 360/460 (77%)
Query: 6 EEIKVAVRKPFLPQGKYLKLEEIEYEXXXXXXXXXXXXXXPALMYYMWLSAQFYNGAPAW 65
EE K FLPQGK+LK EIEYE P LMYYMW+ A+FY+G A
Sbjct: 14 EEKKSKQPVNFLPQGKWLKPNEIEYEFGGTTGVIGMLIGFPLLMYYMWICAEFYHGKVAL 73
Query: 66 PKDGETWGQFLGHLLQLVKDHGVPSLYAWTIFLTFWVAQIVFYYTLPGVWTKGQPLDHLQ 125
PK GE+W F+ HL QLV ++G+P Y WTIFLTFWV QI+FYYTLPG+WTKGQPL HL+
Sbjct: 74 PKAGESWMHFIKHLYQLVLENGIPEKYDWTIFLTFWVFQIIFYYTLPGIWTKGQPLSHLK 133
Query: 126 GKQLPYYCNAMWTFYVSNALIITLHLTGIFKLYTILDMFGEIMTCAIISGFAFSIYLYVY 185
GKQLPY+CNAMWT YV+ L++ LH T +F+LY I+D FG IMTCAIISGFAFSI LY++
Sbjct: 134 GKQLPYFCNAMWTLYVTTTLVLVLHFTNLFRLYVIIDRFGRIMTCAIISGFAFSIILYLW 193
Query: 186 TLTVSKDYHRMTGTHIYDLFMGAPLNPRIGYLDLKMFFEVRLPWYTLYFLTLGACFKQAE 245
TL +S DYHRMTG H+YD FMGAPLNPR G LDLKMFFEVRLPW+TLYF+TLGAC KQ E
Sbjct: 194 TLFISHDYHRMTGNHLYDFFMGAPLNPRWGILDLKMFFEVRLPWFTLYFITLGACLKQWE 253
Query: 246 VYGRVSPQLWLILFAHWSYANACSKGEELIVPTWDMAYEKFGFMLIFWNIAGVPXXXXXX 305
YG V+PQL +++ AHW YANAC+KGEELIVPTWDMAYEKFGFMLIFWNIAGVP
Sbjct: 254 TYGYVTPQLGVVMLAHWLYANACAKGEELIVPTWDMAYEKFGFMLIFWNIAGVPYTYCHC 313
Query: 306 XXXXXXXDPSEYQWSTIYNVSLFVVLMIAYYFFDTTNAQKNSFRKQIAGDKTIRKTFPFL 365
DPSEY WST+YNVSL+VVL+ AYYFFDT NAQKN+FRKQ++GDKT RKTFPFL
Sbjct: 314 TLYLYYHDPSEYHWSTLYNVSLYVVLLCAYYFFDTANAQKNAFRKQMSGDKTGRKTFPFL 373
Query: 366 PKQVLKNPKYMITENGSYLLIDGWYKLARKIHYTADWTQSLIWGLSCGFNSXXXXXXXXX 425
P Q+LKNPKYM+T NGSYLLIDGWY LARKIHYTADWTQSL+W LSCGFNS
Sbjct: 374 PYQILKNPKYMVTSNGSYLLIDGWYTLARKIHYTADWTQSLVWALSCGFNSVFPWFFPVF 433
Query: 426 XXXXLVHRALRDDAKCKKKYGADWDKYCKECPYLFIPYVF 465
L+HRA RD AKCK+KYG DWD+YCK CPY+FIPYVF
Sbjct: 434 FLVVLIHRAFRDQAKCKRKYGKDWDEYCKHCPYVFIPYVF 473
>SPAC20G4.07c [IT] KOG1435 Sterol reductase/lamin B receptor
Length = 453
Score = 434 bits (1115), Expect = e-121
Identities = 214/430 (49%), Positives = 273/430 (62%), Gaps = 13/430 (3%)
Query: 46 PALMYYMWLSAQFYNGAPAWPKDGETWG-----QFLGHLLQLVKDHGVPSLYAWTIFLTF 100
P LMYY+W ++F + P+ G + LGH + + P+ YA+ +F +F
Sbjct: 27 PCLMYYLWACSKFNDSQFIKPESFTIAGFQNFFRTLGHYIYV---GAYPTRYAFLVFWSF 83
Query: 101 WVAQIVFYYTLPGVWTKGQPLDHLQGKQLPYYCNAMWTFYVSNALIITLHLTGIFKLYTI 160
+ Q V Y TLPGV T+G PL H ++LPY CNA+W+FY + ++ LH+T +F + T
Sbjct: 84 CIVQAVMYLTLPGVRTQGLPLKHRNNERLPYLCNAIWSFYTTIVILAVLHVTHVFPITTF 143
Query: 161 LDMFGEIMTCAIISGFAFSIYLYVYTLTVSKDY----HRMTGTHIYDLFMGAPLNPRIG- 215
+DMFG +M+ AII+ F + LY TL HR++G IYD FMGA LNPR+G
Sbjct: 144 IDMFGPLMSVAIITAFVCTFVLYTGTLLFGDRLFDKPHRLSGNPIYDAFMGACLNPRLGK 203
Query: 216 YLDLKMFFEVRLPWYTLYFLTLGACFKQAEVYGRVSPQLWLILFAHWSYANACSKGEELI 275
LD KMFFEVR+PW+ L+F+++GA +Q E YG VSPQ+ + H+ YANACSKGE+LI
Sbjct: 204 LLDFKMFFEVRIPWFILFFISVGAAVRQYETYGTVSPQVLFVCLGHYLYANACSKGEQLI 263
Query: 276 VPTWDMAYEKFGFMLIFWNIAGVPXXXXXXXXXXXXXDPSEYQWSTIYNVSLFVVLMIAY 335
VPTWDMAYEKFGFMLIFWN+AGVP DPS Y WST Y ++V+L+ Y
Sbjct: 264 VPTWDMAYEKFGFMLIFWNMAGVPFTYSHCTLYLFSHDPSVYNWSTQYTTGIYVLLLCCY 323
Query: 336 YFFDTTNAQKNSFRKQIAGDKTIRKTFPFLPKQVLKNPKYMITENGSYLLIDGWYKLARK 395
Y FDT N QKN FR QI G + RKTFP LP ++KNP ++ NG LL GWY+ ARK
Sbjct: 324 YIFDTCNGQKNHFRNQIYGTEVHRKTFPQLPWLIIKNPTFIRCANGGTLLTSGWYRYARK 383
Query: 396 IHYTADWTQSLIWGLSCGFNSXXXXXXXXXXXXXLVHRALRDDAKCKKKYGADWDKYCKE 455
IHYTAD+ QSL W L GF S LVHR RD KCK KYGAD+D+YC+
Sbjct: 384 IHYTADFFQSLSWALITGFQSPLPYFYPCFFFVVLVHRVSRDIKKCKAKYGADFDEYCRI 443
Query: 456 CPYLFIPYVF 465
CPYLFIPY+F
Sbjct: 444 CPYLFIPYIF 453
>Hs4504961 [IT] KOG1435 Sterol reductase/lamin B receptor
Length = 615
Score = 181 bits (458), Expect = 3e-45
Identities = 120/389 (30%), Positives = 184/389 (46%), Gaps = 31/389 (7%)
Query: 88 VPSLY------AWTIFLTFWVAQIVFYYTLPGVWTKGQPLDHLQGKQLPYYCNAMWTFYV 141
+P+LY + ++L +++ Q++FY G +G PL + G++L Y N + F +
Sbjct: 247 LPALYELWETRVFGVYLLWFLIQVLFYLLPIGKVVEGTPL--IDGRRLKYRLNGFYPFIL 304
Query: 142 SNALIITLHLTGIFKLYTILDMFGEIMTCAIISGFAFSIYLYVYTLTVSKD--YHRMTGT 199
++A+I T G+ + + + F + A + S+YLY+ +L ++ +G
Sbjct: 305 TSAVIGTSLFQGV-EFHYVYSHFLQFALAATVFCVVLSVYLYMRSLKAPRNDLSPASSGN 363
Query: 200 HIYDLFMGAPLNPRIGYLDLKMFFEVRLPWYTLYFLTLGACFKQAEVYGRVSPQLWLILF 259
+YD F+G LNPRIG DLK F E+R + L + ++ R P L +IL
Sbjct: 364 AVYDFFIGRELNPRIGTFDLKYFCELRPGLIGWVVINLVMLLAEMKIQDRAVPSLAMILV 423
Query: 260 AHWS--YANACSKGEELIVPTWDMAYEKFGFMLIFWNIAGVPXXXXXXXXXXXXXDPSEY 317
+ Y EE ++ T D+ ++ FGFML F ++ VP P+E
Sbjct: 424 NSFQLLYVVDALWNEEALLTTMDIIHDGFGFMLAFGDLVWVPFIYSFQAFYLVSH-PNEV 482
Query: 318 QWSTIYNVSLFVVLMIA-YYFFDTTNAQKNSFRKQIAGDKTIRKTFPFLPKQVLKNPKYM 376
W SL +VL + Y F N+QKN+FRK P PK L + K +
Sbjct: 483 SWPM---ASLIIVLKLCGYVIFRGANSQKNAFRKN-----------PSDPK--LAHLKTI 526
Query: 377 ITENGSYLLIDGWYKLARKIHYTADWTQSLIWGLSCGFNSXXXXXXXXXXXXXLVHRALR 436
T +G LL+ GW+ R +Y D +L W L CGFN LVHR R
Sbjct: 527 HTSSGKNLLVSGWWGFVRHPNYLGDLIMALAWSLPCGFNHILPYFYIIYFTMLLVHREAR 586
Query: 437 DDAKCKKKYGADWDKYCKECPYLFIPYVF 465
D+ CKKKYG W+KYC+ PY PY++
Sbjct: 587 DEYHCKKKYGVAWEKYCQRVPYRIFPYIY 615
>Hs20537133 [IT] KOG1435 Sterol reductase/lamin B receptor
Length = 615
Score = 181 bits (458), Expect = 3e-45
Identities = 120/389 (30%), Positives = 183/389 (46%), Gaps = 31/389 (7%)
Query: 88 VPSLY------AWTIFLTFWVAQIVFYYTLPGVWTKGQPLDHLQGKQLPYYCNAMWTFYV 141
+P+LY + ++L +++ Q++FY G +G PL + G++L Y N + F +
Sbjct: 247 LPALYELWETRVFGVYLLWFLIQVLFYLLPIGKVVEGTPL--IDGRRLKYRLNGFYAFIL 304
Query: 142 SNALIITLHLTGIFKLYTILDMFGEIMTCAIISGFAFSIYLYVYTLTVSKD--YHRMTGT 199
++A+I T G+ + + + F + A + S+YLY+ +L ++ +G
Sbjct: 305 TSAVIGTSLFQGV-EFHYVYSHFLQFALAATVFCVVLSVYLYMRSLKAPRNDLSPASSGN 363
Query: 200 HIYDLFMGAPLNPRIGYLDLKMFFEVRLPWYTLYFLTLGACFKQAEVYGRVSPQLWLILF 259
+YD F+G LNPRIG DLK F E+R + L + ++ R P L +IL
Sbjct: 364 AVYDFFIGRELNPRIGTFDLKYFCELRPGLIGWVVINLVMLLAEMKIQDRAVPSLAMILV 423
Query: 260 AHWS--YANACSKGEELIVPTWDMAYEKFGFMLIFWNIAGVPXXXXXXXXXXXXXDPSEY 317
+ Y EE ++ T D+ ++ FGFML F ++ VP P+E
Sbjct: 424 NSFQLLYVVDALWNEEALLTTMDIIHDGFGFMLAFGDLVWVPFIYSFQAFYLVSH-PNEV 482
Query: 318 QWSTIYNVSLFVVLMIA-YYFFDTTNAQKNSFRKQIAGDKTIRKTFPFLPKQVLKNPKYM 376
W SL +VL + Y F N+QKN+FRK P PK L + K +
Sbjct: 483 SWPM---ASLIIVLKLCGYVIFRGANSQKNAFRKN-----------PSDPK--LAHLKTI 526
Query: 377 ITENGSYLLIDGWYKLARKIHYTADWTQSLIWGLSCGFNSXXXXXXXXXXXXXLVHRALR 436
T G LL+ GW+ R +Y D +L W L CGFN LVHR R
Sbjct: 527 HTSTGKNLLVSGWWGFVRHPNYLGDLIMALAWSLPCGFNHILPYFYIIYFTMLLVHREAR 586
Query: 437 DDAKCKKKYGADWDKYCKECPYLFIPYVF 465
D+ CKKKYG W+KYC+ PY PY++
Sbjct: 587 DEYHCKKKYGVAWEKYCQRVPYRIFPYIY 615
>SPBC16G5.18 [IT] KOG1435 Sterol reductase/lamin B receptor
Length = 424
Score = 166 bits (421), Expect = 5e-41
Identities = 111/375 (29%), Positives = 173/375 (45%), Gaps = 23/375 (6%)
Query: 96 IFLTFWVAQIVFYYTLPGVWTKGQPLDHLQGKQLPYYCNAMWTFYVSNALIIT-LHLTGI 154
++L ++ + + G W KG P+D +G +L Y N + + ++ T ++L G
Sbjct: 68 LYLLWFSTLTLLWKCTNGKWAKGTPIDD-KGTRLLYKINGFNSACLILGVVCTSIYLLGA 126
Query: 155 FKLYTILDMFGEIMTCAIISGFAFSIYLYVYTLTVSKDYHR--MTGTHIYDLFMGAPLNP 212
+ I D F ++M A + + YV + + + +G ++D F+G LNP
Sbjct: 127 SCMEFIWDNFLQLMFAAYVFSVVLCTFCYVQSFFGKQQLAKGGTSGNILFDWFIGRSLNP 186
Query: 213 RIGYLDLKMFFEVRLPWYTLY--FLTLGACFKQAEVYGRVSPQLWLILFAHWSYANACSK 270
RIG D+K F E+R P L+ F AC + + GR++ + L++ H Y
Sbjct: 187 RIGNFDIKCFCELR-PGLILWVVFDIAFACHQYLVLGGRITDSMVLVIIFHTWYVLDSLI 245
Query: 271 GEELIVPTWDMAYEKFGFMLIFWNIAGVPXXXXXXXXXXXXXDPSEYQWSTIYNVSLFVV 330
E ++ T D+ + FG+ML F ++ VP + +++ +
Sbjct: 246 NESAVLTTMDITTDGFGYMLSFGDLVWVPFLYSLQARYLAFHP---VDLGLVKTLAILCL 302
Query: 331 LMIAYYFFDTTNAQKNSFRKQIAGDKTIRKTFPFLPKQVLKNPKYMITENGSYLLIDGWY 390
+ YY F N QKN FR P PK LK+ K++ T+ G+ LL GW+
Sbjct: 303 QFLGYYIFRGANGQKNRFRSN-----------PNDPK--LKHLKFIQTKRGTKLLTSGWW 349
Query: 391 KLARKIHYTADWTQSLIWGLSCGFNSXXXXXXXXXXXXXLVHRALRDDAKCKKKYGADWD 450
+AR I+Y DW + W L GF S LVHR RDD KC+ KYG DW+
Sbjct: 350 GMARHINYFGDWIMAWAWCLPAGFGSPIPYFYVAYFGVLLVHRNARDDHKCRVKYGEDWE 409
Query: 451 KYCKECPYLFIPYVF 465
KYCK Y IPYV+
Sbjct: 410 KYCKAVKYRIIPYVY 424
>YNL280c [IT] KOG1435 Sterol reductase/lamin B receptor
Length = 438
Score = 143 bits (361), Expect = 5e-34
Identities = 109/392 (27%), Positives = 178/392 (44%), Gaps = 46/392 (11%)
Query: 94 WTIFLTFWVAQIVFYYTLPGVWTKGQPLDHLQGKQLPYYCNAMWTFYVSNALIITLHLTG 153
WT++ ++ V LPG KG L G +L Y N + +S L++ L +
Sbjct: 73 WTVYCLWYGILAVLDVILPGRVMKGVQLR--DGSKLSYKINGI---AMSTTLVLVLAIRW 127
Query: 154 ------IFKLYTILDMFGEIMTCAIISGFAFSIYLYVYT---LTVSKDYHRM-------- 196
+ +L + + + +I+ F + Y YV + L K+ +
Sbjct: 128 KLTDGQLPELQYLYENHVSLCIISILFSFFLATYCYVASFIPLIFKKNGNGKREKILALG 187
Query: 197 --TGTHIYDLFMGAPLNPRIGYLDLKMFFEVRLPWYTLYFLTLGACFKQAEVY-GRVSPQ 253
+G IYD F+G LNPR+G LD+KMF E+R P L+ L +C + G+++
Sbjct: 188 GNSGNIIYDWFIGRELNPRLGPLDIKMFSELR-PGMLLWLLINLSCLHHHYLKTGKINDA 246
Query: 254 LWLILFAHWSYANACSKGEELIVPTWDMAYEKFGFMLIFWNIAGVPXXXXXXXXXXXXXD 313
L L+ F Y EE ++ D+ + FGFML F +++ VP
Sbjct: 247 LVLVNFLQGFYIFDGVLNEEGVLTMMDITTDGFGFMLAFGDLSLVPFTYSLQARYLSVS- 305
Query: 314 PSEYQWSTIYNVSLFVVLMIAYYFFDTTNAQKNSFRKQIAGDKTIRKTFPFLPKQVLKNP 373
P E W + V + ++ + ++ F + N QK+ FR+ L+N
Sbjct: 306 PVELGWVKV--VGILAIMFLGFHIFHSANKQKSEFRQG-----------------KLENL 346
Query: 374 KYMITENGSYLLIDGWYKLARKIHYTADWTQSLIWGLSCGFNSXXXXXXXXXXXXXLVHR 433
K + T+ G+ LL DGW+ ++ I+Y DW SL W L+ F + L+HR
Sbjct: 347 KSIQTKRGTKLLCDGWWAKSQHINYFGDWLISLSWCLATWFQTPLTYYYSLYFATLLLHR 406
Query: 434 ALRDDAKCKKKYGADWDKYCKECPYLFIPYVF 465
RD+ KC+ KYG +W++Y ++ PY IPYV+
Sbjct: 407 QQRDEHKCRLKYGENWEEYERKVPYKIIPYVY 438
>At1g50430 [IT] KOG1435 Sterol reductase/lamin B receptor
Length = 432
Score = 121 bits (304), Expect = 2e-27
Identities = 105/426 (24%), Positives = 174/426 (40%), Gaps = 22/426 (5%)
Query: 46 PALMYYMWLSAQFYNGAPAWPKDGETWGQFLGHLLQ-LVKDHGVPSLYAWTIFLTFWVAQ 104
P + +W + +G+ +T+G F + +Q L+ P+L AW I + +
Sbjct: 23 PPFVILLWYTMVHQDGSVT-----QTFGFFWENGVQGLINIWPRPTLIAWKIIFCYGAFE 77
Query: 105 IVFYYTLPGVWTKGQPLDHLQGKQLPYYCNAMWTFYVSNALIITLHLTGIFKLYTILDMF 164
+ LPG +G P+ G + Y N + ++V+ A + L GIF + D
Sbjct: 78 AILQLLLPGKRVEG-PISPA-GNRPVYKANGLAAYFVTLATYLGLWWFGIFNPAIVYDHL 135
Query: 165 GEIMTCAIISGFAFSIYLYVYT-LTVSKDYHRMTGTHIYDLFMGAPLNPRIGY-LDLKMF 222
GEI + I F F + LY+ + S G I D + G L PRIG D+K+F
Sbjct: 136 GEIFSALIFGSFIFCVLLYIKGHVAPSSSDSGSCGNLIIDFYWGMELYPRIGKSFDIKVF 195
Query: 223 FEVRLPWYTLYFLTLGACFKQAEVYGRVSPQLWLILFAHWSYANACSKGEELIVPTWDMA 282
R + L + C KQ E+ G+VS + + Y E T D+A
Sbjct: 196 TNCRFGMMSWAVLAVTYCIKQYEINGKVSDSMLVNTILMLVYVTKFFWWEAGYWNTMDIA 255
Query: 283 YEKFGFMLIFWNIAGVPXXXXXXXXXXXXXDPSEYQWSTIYNVSLFVVLMIAYYFFDTTN 342
+++ GF + + + VP + T + + V ++ Y +
Sbjct: 256 HDRAGFYICWGCLVWVPSVYTSPGMYLVNHP---VELGTQLAIYILVAGILCIYINYDCD 312
Query: 343 AQKNSFRKQIAGDKTIRKTFPFLPKQVLKNPKYMITENG---SYLLIDGWYKLARKIHYT 399
Q+ FR+ K + + P +++ + Y T S LL GW+ LAR HY
Sbjct: 313 RQRQEFRR--TNGKCL--VWGRAPSKIVAS--YTTTSGETKTSLLLTSGWWGLARHFHYV 366
Query: 400 ADWTQSLIWGLSCGFNSXXXXXXXXXXXXXLVHRALRDDAKCKKKYGADWDKYCKECPYL 459
+ + W + F++ L RA RDD +C+ KYG W YC++ Y
Sbjct: 367 PEILSAFFWTVPALFDNFLAYFYVIFLTLLLFDRAKRDDDRCRSKYGKYWKLYCEKVKYR 426
Query: 460 FIPYVF 465
IP ++
Sbjct: 427 IIPGIY 432
>Hs4503321 [IT] KOG1435 Sterol reductase/lamin B receptor
Length = 475
Score = 119 bits (298), Expect = 1e-26
Identities = 102/384 (26%), Positives = 161/384 (41%), Gaps = 26/384 (6%)
Query: 99 TFWVA-QIVFYYTLPGVWTKGQP--LDHLQ-------GKQLPYYCNAMWTFYVSNAL-II 147
T WV Q++ Y +LP K P + +Q G Y N + + +++ L
Sbjct: 101 TLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFA 160
Query: 148 TLHLTGIFKLYTILDMFGEIMTCAIISGFAFSIYLYV--YTLTVSKDYHRMTGTHIYDLF 205
HL F I D + ++ CA I G+A S + V Y S + TG Y+
Sbjct: 161 NAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYM 220
Query: 206 MGAPLNPRIG-YLDLKMFFEVRLPWYTLYFLTLGACFKQAEVYGRVSPQLWLILFAHWSY 264
MG NPRIG + D K+FF R + L KQ E++ V+ + L+ Y
Sbjct: 221 MGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIY 280
Query: 265 ANACSKGEELIVPTWDMAYEKFGFMLIFWNIAGVPXXXXXXXXXXXXXDPSEYQWSTIYN 324
E + T D+ ++ FG+ L + + +P Q ST +
Sbjct: 281 VIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHP---VQLSTPHA 337
Query: 325 VSLFVVLMIAYYFFDTTNAQKNSFRKQIAGDKTIRKTFPFLPKQVLKNPKYMITE---NG 381
V + ++ ++ YY F N QK+ FR+ T + + K + Y + +
Sbjct: 338 VGVLLLGLVGYYIFRVANHQKDLFRR------TDGRCLIWGRKPKVIECSYTSADGQRHH 391
Query: 382 SYLLIDGWYKLARKIHYTADWTQSLIWGLSCGFNSXXXXXXXXXXXXXLVHRALRDDAKC 441
S LL+ G++ +AR +Y D SL + L+CG L HR LRD+ +C
Sbjct: 392 SKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRC 451
Query: 442 KKKYGADWDKYCKECPYLFIPYVF 465
KYG DW++Y PY +P +F
Sbjct: 452 ASKYGRDWERYTAAVPYRLLPGIF 475
>Hs4507547 [IT] KOG1435 Sterol reductase/lamin B receptor
Length = 589
Score = 115 bits (289), Expect = 1e-25
Identities = 85/307 (27%), Positives = 131/307 (41%), Gaps = 31/307 (10%)
Query: 141 VSNALIITLHLTGIFKLYTILDMFGEIMTCAIISGFAFSIYLYVYTLTVSKDYHRM---T 197
V AL++ L ++ L + +M + A ++ F FS++LY+ +
Sbjct: 241 VLTALLVGLGMSAGLPLGALPEMLLPLAFVATLTAFIFSLFLYMKAQVAPVSALAPGGNS 300
Query: 198 GTHIYDLFMGAPLNPRIGYLDLKMFFEVRLPWYTLYFLTLGACFKQAEVYGRVSPQLWLI 257
G IYD F+G LNPRI + D K F E+R + L K+AE+ G S +WL+
Sbjct: 301 GNPIYDFFLGRELNPRICFFDFKYFCELRPGLIGWVLINLALLMKEAELRGSPSLAMWLV 360
Query: 258 LFAHWSYANACSKGEELIVPTWDMAYEKFGFMLIFWNIAGVPXXXXXXXXXXXXX-DPSE 316
Y EE ++ T D+ ++ FGFML F ++A VP P
Sbjct: 361 NGFQLLYVGDALWHEEAVLTTMDITHDGFGFMLAFGDMAWVPFTYSLQAQFLLHHPQPLG 420
Query: 317 YQWSTIYNVSLFVVLMIAYYFFDTTNAQKNSFRK-----QIAGDKTIRKTFPFLPKQVLK 371
+++ + ++ YY F N+QKN+FRK ++AG +TI
Sbjct: 421 LPMASV----ICLINATGYYIFRGANSQKNTFRKNPSDPRVAGLETIS------------ 464
Query: 372 NPKYMITENGSYLLIDGWYKLARKIHYTADWTQSLIWGLSCGFNSXXXXXXXXXXXXXLV 431
T G LL+ GW+ + R +Y D +L W L CG + LV
Sbjct: 465 ------TATGRKLLVSGWWGMVRHPNYLGDLIMALAWSLPCGVSHLLPYFYLLYFTALLV 518
Query: 432 HRALRDD 438
HR RD+
Sbjct: 519 HREARDE 525
>CE19655_2 [IT] KOG1435 Sterol reductase/lamin B receptor
Length = 412
Score = 72.4 bits (176), Expect = 1e-12
Identities = 83/376 (22%), Positives = 135/376 (35%), Gaps = 23/376 (6%)
Query: 93 AWTIFLTFWVAQIVFYYTLPGVWTKGQPLDHLQGKQLPYYCNAMWTFYVSNALIITLHLT 152
AW Q++FY+ LP Q L N+ ++ ++ L +
Sbjct: 57 AWKFSAVHCAIQLIFYWVLP----HDQALVMSSAGDQMREVNSFFSCILTCLLYVLGASA 112
Query: 153 GIFKLYTILDMFGEIMTCAIISGFAFSIYLYVYTLTVSKDYHRMTGTHIYDLFMGAPLNP 212
G+++ + F I+ F+I+ + + YH T T I + + G +P
Sbjct: 113 GVYRGDLVYLHFNSII-------LIFAIFAVLIWAALIATYHFGTVTTISEFWFGIENHP 165
Query: 213 RIGYLDLKMFFEVRLPWYTLYFLTLGACFKQAEVYGRVSPQLWLILFAHWSYANACSKGE 272
+I +DLK F R + + A + YG++S L + Y E
Sbjct: 166 KILDIDLKSFIRTRFTFVIWPLFVISAMYFHKITYGQISTSLVCLSSVQLLYIFQFHWNE 225
Query: 273 ELIVPTWDMAYEKFGFMLIFWNIAGVPXXXXXXXXXXXXXDPSEYQWSTIYNVSLFVVLM 332
+L + + D FGF I+ + P + S I N V +
Sbjct: 226 DLFLNSLDSKRCDFGFYRIWADFVLGPIIYTSPVTILVATNRSV---GVISNCLFCAVAI 282
Query: 333 IAYYFFDTTNAQKNSFRKQIAGDKTIRKTFPFLPKQVLKNPKYMITE---NGSYLLIDGW 389
+ F + QK FRK K F+ + KY N + LL G
Sbjct: 283 GSMVFTAKCDRQKYEFRKSKGTLKVGGVDAFFI------SAKYRTDSGDANTNLLLGSGH 336
Query: 390 YKLARKIHYTADWTQSLIWGLSCGFNSXXXXXXXXXXXXXLVHRALRDDAKCKKKYGADW 449
+ + R +Y ++ + GF S LV RA D+ +C KYG W
Sbjct: 337 WGVCRHPNYASEAITFAAFSAFQGFPSTIAHIPSLFVILFLVARAFTDENRCLIKYGQYW 396
Query: 450 DKYCKECPYLFIPYVF 465
+YC + Y F+P VF
Sbjct: 397 AQYCSKVKYRFLPGVF 412
>At3g52940 [IT] KOG1435 Sterol reductase/lamin B receptor
Length = 317
Score = 60.8 bits (146), Expect = 4e-09
Identities = 37/137 (27%), Positives = 61/137 (44%), Gaps = 16/137 (11%)
Query: 329 VVLMIAYYFFDTTNAQKNSFRKQIAGDKTIRKTFPFLPKQVLKNPKYMITENGSYLLIDG 388
+V +I Y F N QK+ F+K PK + ++ G LL+ G
Sbjct: 197 LVFLIGYMVFRGANKQKHIFKKN--------------PKTPIWGKPPVVV--GGKLLVSG 240
Query: 389 WYKLARKIHYTADWTQSLIWGLSCGFNSXXXXXXXXXXXXXLVHRALRDDAKCKKKYGAD 448
++ +AR +Y D +L + L CG +S L+ R RD+ +C +KY
Sbjct: 241 YWGIARHCNYLGDLMLALSFSLPCGISSPVPYFYPIYLLILLIWRERRDEVRCAEKYKEI 300
Query: 449 WDKYCKECPYLFIPYVF 465
W +Y + P+ +PYV+
Sbjct: 301 WAEYLRLVPWRILPYVY 317
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.327 0.142 0.477
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,552,196
Number of Sequences: 60738
Number of extensions: 1110658
Number of successful extensions: 2555
Number of sequences better than 1.0e-05: 11
Number of HSP's better than 0.0 without gapping: 8
Number of HSP's successfully gapped in prelim test: 3
Number of HSP's that attempted gapping in prelim test: 2511
Number of HSP's gapped (non-prelim): 12
length of query: 465
length of database: 30,389,216
effective HSP length: 110
effective length of query: 355
effective length of database: 23,708,036
effective search space: 8416352780
effective search space used: 8416352780
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)