ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactI1488 good TU KOG0251 Intracellular trafficking, secretion, and vesicular transport Clathrin assembly protein AP180 and related proteins, contain ENTH domain
r_klactI1488 good TU KOG0251 Signal transduction mechanisms Clathrin assembly protein AP180 and related proteins, contain ENTH domain
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactI1488 507778 509478 567
(567 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YHR161c [TU] KOG0251 Clathrin assembly protein AP180 and related... 375 e-104
YGR241c [TU] KOG0251 Clathrin assembly protein AP180 and related... 332 7e-91
SPBC19F8.03c [TU] KOG0251 Clathrin assembly protein AP180 and re... 157 5e-38
Hs6005733 [TU] KOG0251 Clathrin assembly protein AP180 and relat... 108 2e-23
Hs7662228 [TU] KOG0251 Clathrin assembly protein AP180 and relat... 108 3e-23
7298842 [TU] KOG0251 Clathrin assembly protein AP180 and related... 100 6e-21
CE27813 [TU] KOG0251 Clathrin assembly protein AP180 and related... 92 2e-18
CE27812 [TU] KOG0251 Clathrin assembly protein AP180 and related... 92 2e-18
CE24822 [TU] KOG0251 Clathrin assembly protein AP180 and related... 92 2e-18
CE23565 [TU] KOG0251 Clathrin assembly protein AP180 and related... 92 2e-18
CE23564 [TU] KOG0251 Clathrin assembly protein AP180 and related... 92 2e-18
CE23562 [TU] KOG0251 Clathrin assembly protein AP180 and related... 92 2e-18
At1g14910 [TU] KOG0251 Clathrin assembly protein AP180 and relat... 87 5e-17
At2g01600 [TU] KOG0251 Clathrin assembly protein AP180 and relat... 86 2e-16
At5g57200 [TU] KOG0251 Clathrin assembly protein AP180 and relat... 83 1e-15
Hs22059349 [TU] KOG0251 Clathrin assembly protein AP180 and rela... 79 1e-14
At4g25940 [TU] KOG0251 Clathrin assembly protein AP180 and relat... 71 4e-12
At5g35200 [TU] KOG0251 Clathrin assembly protein AP180 and relat... 66 2e-10
At1g03050 [TU] KOG0251 Clathrin assembly protein AP180 and relat... 61 4e-09
At4g02650_1 [TU] KOG0251 Clathrin assembly protein AP180 and rel... 55 4e-07
>YHR161c [TU] KOG0251 Clathrin assembly protein AP180 and related proteins
contain ENTH domain
Length = 637
Score = 375 bits (964), Expect = e-104
Identities = 211/373 (56%), Positives = 255/373 (67%), Gaps = 40/373 (10%)
Query: 1 MTTYHRLVKGATKIKMAPPKTKYTDPILLGTTNERDFGEIVNALEERINDSAWTVVFKSL 60
MTTY +LVKGATKIK APPK KY DPILLGT+NE DF EIV L+ RIND+AWT+V+KSL
Sbjct: 1 MTTYFKLVKGATKIKSAPPKQKYLDPILLGTSNEEDFYEIVKGLDSRINDTAWTIVYKSL 60
Query: 61 AVAHLMIRDGDKDIALKYFSRNLDFFELRGLARSYPARSGDVQALDRYRLYLKVRSEEYG 120
V HLMIR+G KD+AL+Y+SRNL+FF++ + S + SGD++ALDRY YLKVR E+G
Sbjct: 61 LVVHLMIREGSKDVALRYYSRNLEFFDIENIRGSNGSASGDMRALDRYDNYLKVRCREFG 120
Query: 121 KVRKDYVRNSNTNLKKFDDNRSSE---------CLEHVESLELQIGALIKNRYSQCDLNN 171
K++KDYVR+ LK N S L+HVESLE+QI ALIKN+Y+Q DL+N
Sbjct: 121 KIKKDYVRDGYRTLKLNSGNYGSSRNKQHSINIALDHVESLEVQIQALIKNKYTQYDLSN 180
Query: 172 DLIMFAFKMLVQDLLALYNALNEGIITLLESFFELTRSNAERTLKLYKRFVQLTENVVRY 231
+LI+F FK+L+QDLLALYNALNEGIITLLESFFEL+ NAERTL LYK FV LTE+VVRY
Sbjct: 181 ELIIFGFKLLIQDLLALYNALNEGIITLLESFFELSHHNAERTLDLYKTFVDLTEHVVRY 240
Query: 232 LKSAKAVGLKIPVIKHITTKLINLLEDHLREDTENKGNTFSKDDQTQ-----------VQ 280
LKS K GLKIPVIKHITTKL+ LE+HL ED + NTF D +Q Q
Sbjct: 241 LKSGKTAGLKIPVIKHITTKLVRSLEEHLIED-DKTHNTFVPVDSSQGSAGAVVAKSTAQ 299
Query: 281 SELERIRHQRIALENQLKHXXXXXXXXXXT-----GYNPFATS-------PMSMASPQFD 328
LE+IR Q+ LE QLK+ T YNPF T PM++A+
Sbjct: 300 ERLEQIREQKRILEAQLKNEQVAISPALTTVTAAQSYNPFGTDSSMHTNIPMAVAN---- 355
Query: 329 TRPAQVANTSNPF 341
+ Q+AN NPF
Sbjct: 356 -QTQQIAN--NPF 365
>YGR241c [TU] KOG0251 Clathrin assembly protein AP180 and related proteins
contain ENTH domain
Length = 568
Score = 332 bits (852), Expect = 7e-91
Identities = 185/371 (49%), Positives = 248/371 (65%), Gaps = 33/371 (8%)
Query: 4 YHRLVKGATKIKMAPPKTKYTDPILLGTTNERDFGEIVNALEERINDSAWTVVFKSLAVA 63
Y +LVKGATKIKMAPPK KY DPIL GT++ R EI +AL+ R++D+AWT+V+K+L V
Sbjct: 5 YTKLVKGATKIKMAPPKQKYVDPILSGTSSARGLQEITHALDIRLSDTAWTIVYKALIVL 64
Query: 64 HLMIRDGDKDIALKYFSRNLDFFELRGLARSYPARSGDVQALDRYRLYLKVRSEEYGKVR 123
HLMI+ G+KD+ L+++S NLD F+LR ++ + S D++AL RY YLK R EEYG++
Sbjct: 65 HLMIQQGEKDVTLRHYSHNLDVFQLRKISHTTKWSSNDMRALQRYDEYLKTRCEEYGRLG 124
Query: 124 KDYVRNSNTNLKKFDDNRSS--ECLEHVESLELQIGALIKNRYSQCDLNNDLIMFAFKML 181
D++R++ ++LK N+ S E L+HVESLE+QI ALI+N+YS DL N L+++AF++L
Sbjct: 125 MDHLRDNYSSLKLGSKNQLSMDEELDHVESLEIQINALIRNKYSVSDLENHLLLYAFQLL 184
Query: 182 VQDLLALYNALNEGIITLLESFFELTRSNAERTLKLYKRFVQLTENVVRYLKSAKAVGLK 241
VQDLL LYNALNEG+ITLLESFFEL+ +A+RTL LYK FV +TE VVRYLK KAVGLK
Sbjct: 185 VQDLLGLYNALNEGVITLLESFFELSIEHAKRTLDLYKDFVDMTEYVVRYLKIGKAVGLK 244
Query: 242 IPVIKHITTKLINLLEDHLREDTENK-----------------------GNTFSKDDQTQ 278
IPVIKHITTKLIN LE+HLRE+T+ + N + +++
Sbjct: 245 IPVIKHITTKLINSLEEHLREETKRQRGEPSEPQQDRKPSTAISSTSSHNNNSNDKNKSI 304
Query: 279 VQSELERIRHQRIALENQLKHXXXXXX-XXXXTGYNPFATSPMSMASPQFDTRP------ 331
Q +LE+IR Q+ LE QL++ YNPF + + + F P
Sbjct: 305 AQKKLEQIREQKRLLEQQLQNQQLLISPTVPQDAYNPFGSQQQDLNNDTFSFEPTQPQMT 364
Query: 332 AQVAN-TSNPF 341
AQV T+NPF
Sbjct: 365 AQVPQPTANPF 375
Score = 50.8 bits (120), Expect = 5e-06
Identities = 50/142 (35%), Positives = 67/142 (46%), Gaps = 40/142 (28%)
Query: 457 NNAA-TAPIIPSKTGPNNPFSLENVNRQQLQ---RQQTNPFSVQN--------YSQVSNN 504
NNA T + P+KTG NNPFSLEN+ R+Q Q + NPF++Q +SQ + N
Sbjct: 436 NNAIMTGTLDPTKTGSNNPFSLENIAREQQQQNFQNSPNPFTLQQAQTTPILAHSQ-TGN 494
Query: 505 PFS-----TAP----ESSPLIVPPNRATTG--------NNTFGGLELLPT--VPVFPQTQ 545
PF T+P ++P+ A+TG G ++PT VP+ Q Q
Sbjct: 495 PFQAQNVVTSPMGTYMTNPVAGQLQYASTGAQQQPQMMQGQQTGYVMVPTAFVPINQQQQ 554
Query: 546 IQQGFQAVANQRSQNEPNLIDI 567
Q Q Q PNLIDI
Sbjct: 555 QQ--------QHQQENPNLIDI 568
>SPBC19F8.03c [TU] KOG0251 Clathrin assembly protein AP180 and related proteins
contain ENTH domain
Length = 649
Score = 157 bits (396), Expect = 5e-38
Identities = 90/268 (33%), Positives = 161/268 (59%), Gaps = 10/268 (3%)
Query: 1 MTTYHRLVKGATKIKMAPPKTKYTDPILLGTTNERDFGE-IVNALEERINDSAWTVVFKS 59
+ TY R VK ATK+K+A PK K+ + IL TT + + E ++ AL ER+ + +WT+VFK+
Sbjct: 7 LLTYERAVKKATKVKLAAPKYKHVEIILEATTEDPETLENVIQALCERLKEQSWTIVFKT 66
Query: 60 LAVAHLMIRDGDKDIALKYFSRNLDFFELRGLARSYPARSGDVQALDRYRLYLKVRSEEY 119
L V H+M+++G + + S+ E+ A S A+ ++ Y +L R+++Y
Sbjct: 67 LIVFHVMLKEGAPNTTIVALSQRPRILEVLK-ASSLLAQGKNIY---NYSRFLSERAKQY 122
Query: 120 GKVRKDYVRNSNTNLKKFDDNR-SSECLEHVESLELQIGALIKNRYSQCDLNNDLIMFAF 178
G++ DY + + KK + + + L +VE ++ Q+ LIK ++ +++ND+ + AF
Sbjct: 123 GRLGVDYAQVGDAPKKKIREMKLENGLLRNVEGIQAQLRRLIKCQFVAEEIDNDIAITAF 182
Query: 179 KMLVQDLLALYNALNEGIITLLESFFELTRSNAERTLKLYKRFVQLTENVVRYLKSAKAV 238
++LV DLL L+ A+N G+I +LE +FE+ +A ++L++YK FV TE+++ YL +A+++
Sbjct: 183 RLLVGDLLVLFKAVNIGVINVLEHYFEMGHHDAAQSLRIYKTFVNQTEDIINYLSTARSL 242
Query: 239 ----GLKIPVIKHITTKLINLLEDHLRE 262
+P IKH L LE++L +
Sbjct: 243 EFVTKFPVPNIKHAPISLTASLEEYLND 270
>Hs6005733 [TU] KOG0251 Clathrin assembly protein AP180 and related proteins
contain ENTH domain
Length = 652
Score = 108 bits (271), Expect = 2e-23
Identities = 95/361 (26%), Positives = 165/361 (45%), Gaps = 35/361 (9%)
Query: 11 ATKIKMAPPKTKYTDPILLGTTNERDFG--EIVNALEERINDSAWTVVFKSLAVAHLMIR 68
AT ++ PK K+ D L+ TNE + ++ ++L ER +S+W VVFKSL H ++
Sbjct: 29 ATTHEIMGPKKKHLD-YLIQCTNEMNVNIPQLADSLFERTTNSSWVVVFKSLITTHHLMV 87
Query: 69 DGDKDIALKYFSRNLDFFELRGLARSYPARSGDVQA-LDRYRLYLKVRSEEYGKVRKDYV 127
G++ SRN F L + D+ + RY YL ++ Y +V D+
Sbjct: 88 YGNERFIQYLASRNT-LFNLSNFLDKSGLQGYDMSTFIRRYSRYLNEKAVSYRQVAFDFT 146
Query: 128 RNSNTNLKKFDDNRSSECLEHVESLELQIGALIKNRYSQCDLNNDLIMFAFKMLVQDLLA 187
+ + + L+ V ++ Q+ AL+ + +L N +I AF +L +D +
Sbjct: 147 KVKRGADGVMRTMNTEKLLKTVPIIQNQMDALLDFNVNSNELTNGVINAAFMLLFKDAIR 206
Query: 188 LYNALNEGIITLLESFFELTRSNAERTLKLYKRFVQLTENVVRYLKSAKAVGL---KIPV 244
L+ A +EGII LLE +F++ ++ + L +YK+F+ + +LK A+ VG+ IP
Sbjct: 207 LFAAYHEGIINLLEKYFDMKKNQCKEGLDIYKKFLTRMTRISEFLKVAEQVGIDRGDIPD 266
Query: 245 IKHITTKLINLLEDHLR-----------------------EDTENKGNTFSKDDQTQVQS 281
+ + L++ LE HL + G + +K D+ + Q+
Sbjct: 267 LSQAPSSLLDALEQHLASLEGKKIKDSTAASRATTLSNAVSSLASTGLSLTKVDEREKQA 326
Query: 282 ELERIRHQRIAL-ENQLKHXXXXXXXXXXTGYNPFATSPMS-MASPQFD--TRPAQVANT 337
LE + + AL E +LK T +P +TS M +P D + P+ +T
Sbjct: 327 ALEEEQARLKALKEQRLKELAKKPHTSLTTAASPVSTSAGGIMTAPAIDIFSTPSSSNST 386
Query: 338 S 338
S
Sbjct: 387 S 387
>Hs7662228 [TU] KOG0251 Clathrin assembly protein AP180 and related proteins
contain ENTH domain
Length = 907
Score = 108 bits (269), Expect = 3e-23
Identities = 79/261 (30%), Positives = 128/261 (48%), Gaps = 8/261 (3%)
Query: 6 RLVKGATKIKMAPPKTKYTDPILLGTTNERDFG--EIVNALEERINDSAWTVVFKSLAVA 63
R V AT ++ PK K+ D L+ TNE + ++ + L ER +S+W VVFK+L
Sbjct: 24 RAVCKATTHEVMGPKKKHLD-YLIQATNETNVNIPQMADTLFERATNSSWVVVFKALVTT 82
Query: 64 HLMIRDGDKDIALKYFSRNLDFFELRGLARSYPARSGDVQA-LDRYRLYLKVRSEEYGKV 122
H ++ G++ SRN F L + D+ + RY YL ++ Y ++
Sbjct: 83 HHLMVHGNERFIQYLASRNT-LFNLSNFLDKSGSHGYDMSTFIRRYSRYLNEKAFSYRQM 141
Query: 123 RKDYVRNSNTNLKKFDDNRSSECLEHVESLELQIGALIKNRYSQCDLNNDLIMFAFKMLV 182
D+ R + L+ + L+ QI AL++ +L N +I AF +L
Sbjct: 142 AFDFARVKKGADGVMRTMAPEKLLKSMPILQGQIDALLEFDVHPNELTNGVINAAFMLLF 201
Query: 183 QDLLALYNALNEGIITLLESFFELTRSNAERTLKLYKRFVQLTENVVRYLKSAKAVGL-- 240
+DL+ L+ N+G+I LLE FFE+ + + L++YKRF+ V +LK A+ VG+
Sbjct: 202 KDLIKLFACYNDGVINLLEKFFEMKKGQCKDALEIYKRFLTRMTRVSEFLKVAEQVGIDK 261
Query: 241 -KIPVIKHITTKLINLLEDHL 260
IP + + L+ LE HL
Sbjct: 262 GDIPDLTQAPSSLMETLEQHL 282
>7298842 [TU] KOG0251 Clathrin assembly protein AP180 and related proteins
contain ENTH domain
Length = 468
Score = 100 bits (249), Expect = 6e-21
Identities = 92/358 (25%), Positives = 159/358 (43%), Gaps = 44/358 (12%)
Query: 11 ATKIKMAPPKTKYTDPILLGTTNERDFG--EIVNALEERINDSAWTVVFKSLAVAHLMIR 68
AT + PK K+ D L+ TNE + + N L ER ++ W VV+KSL H ++
Sbjct: 31 ATTEECIGPKKKHLD-YLVHCTNEPNVSIPHLANLLIERSQNANWVVVYKSLITTHHLMA 89
Query: 69 DGDKDIALKYFSRNLDFFELRGLARSYPARSGDVQA------------LDRYRLYLKVRS 116
G++ ++Y + + F L + G + + RY YL +S
Sbjct: 90 YGNERF-MQYLASSNSTFNLSSFLDKGTVQDGGMGVPGGRMGYDMSPFIRRYAKYLNEKS 148
Query: 117 EEYGKVRKDYVRNSNTNLK-KFDDNRSSECLEHVESLELQIGALIKNRYSQCDLNNDLIM 175
Y + D+ + + + + L+ + L+ Q+ AL++ DL+N +I
Sbjct: 149 LSYRAMAFDFCKVKRGKEEGSLRSMNAEKLLKTLPVLQAQLDALLEFDCQSNDLSNGVIN 208
Query: 176 FAFKMLVQDLLALYNALNEGIITLLESFFELTRSNAERTLKLYKRFVQLTENVVRYLKSA 235
+F +L +DL+ L+ N+GII LLE +F++ + +A L LYK+F+ + V +LK A
Sbjct: 209 MSFMLLFRDLIRLFACYNDGIINLLEKYFDMNKKHARDALDLYKKFLVRMDRVGEFLKVA 268
Query: 236 KAVGL---KIPVIKHITTKLINLLEDHL-----------REDTENKGNTF------SKDD 275
+ VG+ IP + + L++ LE HL T++ + F SK D
Sbjct: 269 ENVGIDKGDIPDLTKAPSSLLDALEQHLATLEGRKVSAANTPTQSSSSAFGTAAASSKFD 328
Query: 276 QTQ-VQSELE-RIRHQRIALENQLKHXXXXXXXXXXTG-----YNPFATSPMSMASPQ 326
T + +L+ ++ + A NQ K G NPF +SP + + Q
Sbjct: 329 TTNGIDEQLKAQVLAEEEAAMNQYKSKVSSPTSSGAAGASAALTNPFLSSPPAAQAGQ 386
>CE27813 [TU] KOG0251 Clathrin assembly protein AP180 and related proteins
contain ENTH domain
Length = 548
Score = 92.4 bits (228), Expect = 2e-18
Identities = 73/259 (28%), Positives = 125/259 (48%), Gaps = 12/259 (4%)
Query: 11 ATKIKMAPPKTKYTDPILLGTTNERDFG--EIVNALEERINDSAWTVVFKSLAVAHLMIR 68
AT ++ PK K+ D LL TNE + + N L ER + WTVV+K+L H ++
Sbjct: 44 ATTEEVMAPKKKHLD-YLLHCTNEPNVSIPSMANLLIERTQNPNWTVVYKALITIHNIMC 102
Query: 69 DGDKDIALKYFSRNLDFFELRGLARSYPARSGDVQA-LDRYRLYLKVRSEEYGKVRKDYV 127
G++ + S N F + + A D+ + RY Y+ + Y D+
Sbjct: 103 YGNERFSQYLASCNTTFNLTAFVDKVGGAGGYDMSTHVRRYAKYIGEKINTYRMCAFDFC 162
Query: 128 ---RNSNTNLKKFDDNRSSECLEHVESLELQIGALIKNRYSQCDLNNDLIMFAFKMLVQD 184
R L + + + L+ + L+ QI AL++ + +LNN +I +F +L +D
Sbjct: 163 KVKRGREDGLLR--TMHTDKLLKTIPILQNQIDALLEFSVTTSELNNGVINCSFILLFRD 220
Query: 185 LLALYNALNEGIITLLESFFELTRSNAERTLKLYKRFVQLTENVVRYLKSAKAVGL---K 241
L+ L+ N+GII +LE +F++ + L YK F+ + V +L+ A++VG+ +
Sbjct: 221 LIRLFACYNDGIINVLEKYFDMNKKQCRDALDTYKSFLTRLDKVAEFLRVAESVGIDRGE 280
Query: 242 IPVIKHITTKLINLLEDHL 260
IP + L+ LE HL
Sbjct: 281 IPDLTRAPASLLEALEAHL 299
>CE27812 [TU] KOG0251 Clathrin assembly protein AP180 and related proteins
contain ENTH domain
Length = 546
Score = 92.4 bits (228), Expect = 2e-18
Identities = 73/259 (28%), Positives = 125/259 (48%), Gaps = 12/259 (4%)
Query: 11 ATKIKMAPPKTKYTDPILLGTTNERDFG--EIVNALEERINDSAWTVVFKSLAVAHLMIR 68
AT ++ PK K+ D LL TNE + + N L ER + WTVV+K+L H ++
Sbjct: 44 ATTEEVMAPKKKHLD-YLLHCTNEPNVSIPSMANLLIERTQNPNWTVVYKALITIHNIMC 102
Query: 69 DGDKDIALKYFSRNLDFFELRGLARSYPARSGDVQA-LDRYRLYLKVRSEEYGKVRKDYV 127
G++ + S N F + + A D+ + RY Y+ + Y D+
Sbjct: 103 YGNERFSQYLASCNTTFNLTAFVDKVGGAGGYDMSTHVRRYAKYIGEKINTYRMCAFDFC 162
Query: 128 ---RNSNTNLKKFDDNRSSECLEHVESLELQIGALIKNRYSQCDLNNDLIMFAFKMLVQD 184
R L + + + L+ + L+ QI AL++ + +LNN +I +F +L +D
Sbjct: 163 KVKRGREDGLLR--TMHTDKLLKTIPILQNQIDALLEFSVTTSELNNGVINCSFILLFRD 220
Query: 185 LLALYNALNEGIITLLESFFELTRSNAERTLKLYKRFVQLTENVVRYLKSAKAVGL---K 241
L+ L+ N+GII +LE +F++ + L YK F+ + V +L+ A++VG+ +
Sbjct: 221 LIRLFACYNDGIINVLEKYFDMNKKQCRDALDTYKSFLTRLDKVAEFLRVAESVGIDRGE 280
Query: 242 IPVIKHITTKLINLLEDHL 260
IP + L+ LE HL
Sbjct: 281 IPDLTRAPASLLEALEAHL 299
>CE24822 [TU] KOG0251 Clathrin assembly protein AP180 and related proteins
contain ENTH domain
Length = 657
Score = 92.4 bits (228), Expect = 2e-18
Identities = 73/259 (28%), Positives = 125/259 (48%), Gaps = 12/259 (4%)
Query: 11 ATKIKMAPPKTKYTDPILLGTTNERDFG--EIVNALEERINDSAWTVVFKSLAVAHLMIR 68
AT ++ PK K+ D LL TNE + + N L ER + WTVV+K+L H ++
Sbjct: 44 ATTEEVMAPKKKHLD-YLLHCTNEPNVSIPSMANLLIERTQNPNWTVVYKALITIHNIMC 102
Query: 69 DGDKDIALKYFSRNLDFFELRGLARSYPARSGDVQA-LDRYRLYLKVRSEEYGKVRKDYV 127
G++ + S N F + + A D+ + RY Y+ + Y D+
Sbjct: 103 YGNERFSQYLASCNTTFNLTAFVDKVGGAGGYDMSTHVRRYAKYIGEKINTYRMCAFDFC 162
Query: 128 ---RNSNTNLKKFDDNRSSECLEHVESLELQIGALIKNRYSQCDLNNDLIMFAFKMLVQD 184
R L + + + L+ + L+ QI AL++ + +LNN +I +F +L +D
Sbjct: 163 KVKRGREDGLLR--TMHTDKLLKTIPILQNQIDALLEFSVTTSELNNGVINCSFILLFRD 220
Query: 185 LLALYNALNEGIITLLESFFELTRSNAERTLKLYKRFVQLTENVVRYLKSAKAVGL---K 241
L+ L+ N+GII +LE +F++ + L YK F+ + V +L+ A++VG+ +
Sbjct: 221 LIRLFACYNDGIINVLEKYFDMNKKQCRDALDTYKSFLTRLDKVAEFLRVAESVGIDRGE 280
Query: 242 IPVIKHITTKLINLLEDHL 260
IP + L+ LE HL
Sbjct: 281 IPDLTRAPASLLEALEAHL 299
>CE23565 [TU] KOG0251 Clathrin assembly protein AP180 and related proteins
contain ENTH domain
Length = 467
Score = 92.4 bits (228), Expect = 2e-18
Identities = 73/259 (28%), Positives = 125/259 (48%), Gaps = 12/259 (4%)
Query: 11 ATKIKMAPPKTKYTDPILLGTTNERDFG--EIVNALEERINDSAWTVVFKSLAVAHLMIR 68
AT ++ PK K+ D LL TNE + + N L ER + WTVV+K+L H ++
Sbjct: 44 ATTEEVMAPKKKHLD-YLLHCTNEPNVSIPSMANLLIERTQNPNWTVVYKALITIHNIMC 102
Query: 69 DGDKDIALKYFSRNLDFFELRGLARSYPARSGDVQA-LDRYRLYLKVRSEEYGKVRKDYV 127
G++ + S N F + + A D+ + RY Y+ + Y D+
Sbjct: 103 YGNERFSQYLASCNTTFNLTAFVDKVGGAGGYDMSTHVRRYAKYIGEKINTYRMCAFDFC 162
Query: 128 ---RNSNTNLKKFDDNRSSECLEHVESLELQIGALIKNRYSQCDLNNDLIMFAFKMLVQD 184
R L + + + L+ + L+ QI AL++ + +LNN +I +F +L +D
Sbjct: 163 KVKRGREDGLLR--TMHTDKLLKTIPILQNQIDALLEFSVTTSELNNGVINCSFILLFRD 220
Query: 185 LLALYNALNEGIITLLESFFELTRSNAERTLKLYKRFVQLTENVVRYLKSAKAVGL---K 241
L+ L+ N+GII +LE +F++ + L YK F+ + V +L+ A++VG+ +
Sbjct: 221 LIRLFACYNDGIINVLEKYFDMNKKQCRDALDTYKSFLTRLDKVAEFLRVAESVGIDRGE 280
Query: 242 IPVIKHITTKLINLLEDHL 260
IP + L+ LE HL
Sbjct: 281 IPDLTRAPASLLEALEAHL 299
>CE23564 [TU] KOG0251 Clathrin assembly protein AP180 and related proteins
contain ENTH domain
Length = 534
Score = 92.4 bits (228), Expect = 2e-18
Identities = 73/259 (28%), Positives = 125/259 (48%), Gaps = 12/259 (4%)
Query: 11 ATKIKMAPPKTKYTDPILLGTTNERDFG--EIVNALEERINDSAWTVVFKSLAVAHLMIR 68
AT ++ PK K+ D LL TNE + + N L ER + WTVV+K+L H ++
Sbjct: 44 ATTEEVMAPKKKHLD-YLLHCTNEPNVSIPSMANLLIERTQNPNWTVVYKALITIHNIMC 102
Query: 69 DGDKDIALKYFSRNLDFFELRGLARSYPARSGDVQA-LDRYRLYLKVRSEEYGKVRKDYV 127
G++ + S N F + + A D+ + RY Y+ + Y D+
Sbjct: 103 YGNERFSQYLASCNTTFNLTAFVDKVGGAGGYDMSTHVRRYAKYIGEKINTYRMCAFDFC 162
Query: 128 ---RNSNTNLKKFDDNRSSECLEHVESLELQIGALIKNRYSQCDLNNDLIMFAFKMLVQD 184
R L + + + L+ + L+ QI AL++ + +LNN +I +F +L +D
Sbjct: 163 KVKRGREDGLLR--TMHTDKLLKTIPILQNQIDALLEFSVTTSELNNGVINCSFILLFRD 220
Query: 185 LLALYNALNEGIITLLESFFELTRSNAERTLKLYKRFVQLTENVVRYLKSAKAVGL---K 241
L+ L+ N+GII +LE +F++ + L YK F+ + V +L+ A++VG+ +
Sbjct: 221 LIRLFACYNDGIINVLEKYFDMNKKQCRDALDTYKSFLTRLDKVAEFLRVAESVGIDRGE 280
Query: 242 IPVIKHITTKLINLLEDHL 260
IP + L+ LE HL
Sbjct: 281 IPDLTRAPASLLEALEAHL 299
>CE23562 [TU] KOG0251 Clathrin assembly protein AP180 and related proteins
contain ENTH domain
Length = 586
Score = 92.4 bits (228), Expect = 2e-18
Identities = 73/259 (28%), Positives = 125/259 (48%), Gaps = 12/259 (4%)
Query: 11 ATKIKMAPPKTKYTDPILLGTTNERDFG--EIVNALEERINDSAWTVVFKSLAVAHLMIR 68
AT ++ PK K+ D LL TNE + + N L ER + WTVV+K+L H ++
Sbjct: 44 ATTEEVMAPKKKHLD-YLLHCTNEPNVSIPSMANLLIERTQNPNWTVVYKALITIHNIMC 102
Query: 69 DGDKDIALKYFSRNLDFFELRGLARSYPARSGDVQA-LDRYRLYLKVRSEEYGKVRKDYV 127
G++ + S N F + + A D+ + RY Y+ + Y D+
Sbjct: 103 YGNERFSQYLASCNTTFNLTAFVDKVGGAGGYDMSTHVRRYAKYIGEKINTYRMCAFDFC 162
Query: 128 ---RNSNTNLKKFDDNRSSECLEHVESLELQIGALIKNRYSQCDLNNDLIMFAFKMLVQD 184
R L + + + L+ + L+ QI AL++ + +LNN +I +F +L +D
Sbjct: 163 KVKRGREDGLLR--TMHTDKLLKTIPILQNQIDALLEFSVTTSELNNGVINCSFILLFRD 220
Query: 185 LLALYNALNEGIITLLESFFELTRSNAERTLKLYKRFVQLTENVVRYLKSAKAVGL---K 241
L+ L+ N+GII +LE +F++ + L YK F+ + V +L+ A++VG+ +
Sbjct: 221 LIRLFACYNDGIINVLEKYFDMNKKQCRDALDTYKSFLTRLDKVAEFLRVAESVGIDRGE 280
Query: 242 IPVIKHITTKLINLLEDHL 260
IP + L+ LE HL
Sbjct: 281 IPDLTRAPASLLEALEAHL 299
>At1g14910 [TU] KOG0251 Clathrin assembly protein AP180 and related proteins
contain ENTH domain
Length = 692
Score = 87.4 bits (215), Expect = 5e-17
Identities = 70/271 (25%), Positives = 124/271 (44%), Gaps = 19/271 (7%)
Query: 11 ATKIKMAPPKTKYTDPILLGTTNER---DFGEIVNALEERINDSA-WTVVFKSLAVAHLM 66
AT PPK ++ I L T+ R D ++AL R++ + WTV K+L V H +
Sbjct: 39 ATNHVECPPKDRHLRKIFLATSAIRPRADVAYCIHALSRRLHKTRNWTVALKALLVIHRL 98
Query: 67 IRDGDKDIA--LKYFSRNLDFFELRGLARSYPARSGDVQALDR-YRLYLKVRSEEYGKVR 123
+RDGD L FS+ ++ + D R Y L+L+ R E + ++
Sbjct: 99 LRDGDPTFREELLNFSQKGRIMQISNFKDDSSPVAWDCSGWVRTYALFLEERLECFRVLK 158
Query: 124 KDYVRN--------SNTNLKKFDDNRSSECLEHVESLELQIGALIKNRYSQCDLNNDLIM 175
D K D + LE + +L+ + LI + +N +I
Sbjct: 159 YDIEAERLPKVSPGQEKGYSKTRDLDGEKLLEQLPALQQLLHRLIGCKPEGAAKHNHIIQ 218
Query: 176 FAFKMLVQDLLALYNALNEGIITLLESFFELTRSNAERTLKLYKRFVQLTENVVRYLKSA 235
+A +++++ +Y A+NEGII L+E FFE+ R A + L++YKR N+ + +
Sbjct: 219 YALSLVLKESFKVYCAINEGIINLVEKFFEMPRHEAIKALEIYKRAGLQAGNLSAFYEVC 278
Query: 236 KAVGL----KIPVIKHITTKLINLLEDHLRE 262
K + L + PV++ + +E+++R+
Sbjct: 279 KGLELARNFQFPVLREPPQSFLTTMEEYMRD 309
>At2g01600 [TU] KOG0251 Clathrin assembly protein AP180 and related proteins
contain ENTH domain
Length = 571
Score = 85.9 bits (211), Expect = 2e-16
Identities = 71/271 (26%), Positives = 129/271 (47%), Gaps = 19/271 (7%)
Query: 11 ATKIKMAPPKTKYTDPILLGTTNER---DFGEIVNALEERINDSA-WTVVFKSLAVAHLM 66
AT PPK ++ I T+ R D ++AL R++ + WTV K+L V H +
Sbjct: 39 ATNHVECPPKDRHLRKIFAATSVTRARADVAYCIHALSRRLHKTRNWTVALKTLIVIHRL 98
Query: 67 IRDGDKDIA--LKYFSRNLDFFELRGLARSYPARSGDVQALDR-YRLYLKVRSEEYGKVR 123
+R+GD L FS+ +L + D A R Y L+L+ R E + ++
Sbjct: 99 LREGDPTFREELLNFSQRGRILQLSNFKDDSSPIAWDCSAWVRTYALFLEERLECFRVLK 158
Query: 124 KDY----VRNSNTNLKK----FDDNRSSECLEHVESLELQIGALIKNRYSQCDLNNDLIM 175
D + SN K D E LE + +L+ + LI R +N +I
Sbjct: 159 YDTEAERLPKSNPGQDKGYSRTRDLDGEELLEQLPALQQLLYRLIGCRPEGAANHNHVIQ 218
Query: 176 FAFKMLVQDLLALYNALNEGIITLLESFFELTRSNAERTLKLYKRFVQLTENVVRYLKSA 235
+A +++++ +Y A+N+GII L++ FFE+ + A +L++YKR Q ++ + ++
Sbjct: 219 YALALVLKESFKVYCAINDGIINLIDKFFEMAKHEAITSLEIYKRAGQQARSLSDFYEAC 278
Query: 236 KAVGL----KIPVIKHITTKLINLLEDHLRE 262
K + L + PV++ + +E++++E
Sbjct: 279 KGLELARNFQFPVLREPPQSFLTTMEEYIKE 309
>At5g57200 [TU] KOG0251 Clathrin assembly protein AP180 and related proteins
contain ENTH domain
Length = 591
Score = 83.2 bits (204), Expect = 1e-15
Identities = 72/295 (24%), Positives = 133/295 (44%), Gaps = 23/295 (7%)
Query: 11 ATKIKMAPPKTKYTDPILLGTT---NERDFGEIVNALEERINDSA-WTVVFKSLAVAHLM 66
AT +PPK ++ I T+ D ++AL +R++ + W V K L V H
Sbjct: 39 ATNHVESPPKERHVRKIFSATSVIQPRADVAYCIHALSKRLSKTRNWVVAMKVLIVIHRT 98
Query: 67 IRDGDKDIA--LKYFSRNLDFFELRGLARSYPARSGDVQALDR-YRLYLKVRSEEYGKVR 123
+R+GD L +S + + D A R Y L+L+ R E Y ++
Sbjct: 99 LREGDPTFREELLNYSHRRHILRISNFKDDTSPLAWDCSAWVRTYALFLEERLECYRVLK 158
Query: 124 KDY----VRNSNTNLKKFDDNR---SSECLEHVESLELQIGALIKNRYSQCDLNNDLIMF 176
D + ++ K R + LE + +L+ + LI + +N LI +
Sbjct: 159 YDIEAERLPKASGAASKTHRTRMLSGEDLLEQLPALQQLLYRLIGCQPEGAAYSNYLIQY 218
Query: 177 AFKMLVQDLLALYNALNEGIITLLESFFELTRSNAERTLKLYKRFVQLTENVVRYLKSAK 236
A +++++ +Y A+N+GII L++ FFE++R +A + L +YKR Q EN+ + K
Sbjct: 219 ALALVLKESFKIYCAINDGIINLVDMFFEMSRHDAVKALNIYKRAGQQAENLAEFYDYCK 278
Query: 237 AVGL----KIPVIKHITTKLINLLEDHLRE-----DTENKGNTFSKDDQTQVQSE 282
+ L + P ++ + +E++++E + K K+++ Q Q E
Sbjct: 279 GLELARNFQFPTLRQPPPSFLATMEEYIKEAPQSGSVQKKLEYQEKEEEEQEQEE 333
>Hs22059349 [TU] KOG0251 Clathrin assembly protein AP180 and related proteins
contain ENTH domain
Length = 276
Score = 79.3 bits (194), Expect = 1e-14
Identities = 62/230 (26%), Positives = 100/230 (42%), Gaps = 33/230 (14%)
Query: 10 GATKIKMAPPKTKYTDPILLGTTNERDFGEIVNALEERINDSAWTVVFKSLAVAHLMIRD 69
GAT + P+ K D I + + N L E+ S+W VVFK+L H ++
Sbjct: 11 GATTDEPMEPEPKLADLIQYISETNISVEHLANVLSEKTRSSSWVVVFKALVTVHHLMVH 70
Query: 70 GDKDIALKYFSRNLDFFELRGLARSYPARSGDVQALDRYRLYLKVRSEEYGKVRKDYVRN 129
G++ +L LD + + Y R V + RY YL +S Y + D
Sbjct: 71 GNES-SLFTLHNFLDKSVIEDIVEVY--RLYYVNFIRRYSKYLNEKSLAYRMISSDI--- 124
Query: 130 SNTNLKKFDDNRSSECLEHVESLELQIGALIKNRYSQCDLNNDLIMFAFKMLVQDLLALY 189
T K+ N +L N +I AF +L +D L L+
Sbjct: 125 --TKTKRGSANPD-------------------------ELTNGIIHAAFMLLFKDSLCLF 157
Query: 190 NALNEGIITLLESFFELTRSNAERTLKLYKRFVQLTENVVRYLKSAKAVG 239
A NEGI+ LL+ +F++ ++ +L +Y RF++ T + ++LK A+ VG
Sbjct: 158 AAYNEGILNLLDKYFDMRKNQCRESLDIYIRFLRGTTKLTQFLKVAEQVG 207
>At4g25940 [TU] KOG0251 Clathrin assembly protein AP180 and related proteins
contain ENTH domain
Length = 574
Score = 71.2 bits (173), Expect = 4e-12
Identities = 63/236 (26%), Positives = 108/236 (45%), Gaps = 23/236 (9%)
Query: 7 LVKGATKIKMAPPKTKYTDPILLGTT---NERDFGEIVNALEERINDSA-WTVVFKSLAV 62
+VK ++ AP K ++ I T+ D ++AL +R++ + W V K L V
Sbjct: 36 IVKATNHVESAP-KERHIRRIFSATSVVQPRADVAYCIHALAKRLSKTRNWVVAIKVLIV 94
Query: 63 AHLMIRDGDKDIA--LKYFSRNLDFFELRGLARSYPARSGDVQALDR-YRLYLKVRSEEY 119
H +R+GD L +S + + D A R Y L+L+ R E Y
Sbjct: 95 IHRTLREGDPTFREELLNYSHRGHILRISNFKDDTSPLAWDCSAWIRTYALFLEERLECY 154
Query: 120 GKVRKDYV-----RNSNTNLKKFDDNRSS----------ECLEHVESLELQIGALIKNRY 164
++ D + S + K D N S E LE + +L+ + LI +
Sbjct: 155 RVLKYDIEAERLPKGSGASSKNVDFNASQTYRTRMLSDEELLEQLPALQQLLYRLIGCQP 214
Query: 165 SQCDLNNDLIMFAFKMLVQDLLALYNALNEGIITLLESFFELTRSNAERTLKLYKR 220
+N LI +A +++++ +Y A+N+GII L++ FFE++R +A + L +YKR
Sbjct: 215 EGSAYSNYLIQYALALVLKESFKIYCAINDGIINLVDMFFEMSRHDAVKALNIYKR 270
>At5g35200 [TU] KOG0251 Clathrin assembly protein AP180 and related proteins
contain ENTH domain
Length = 544
Score = 65.9 bits (159), Expect = 2e-10
Identities = 55/264 (20%), Positives = 119/264 (44%), Gaps = 16/264 (6%)
Query: 11 ATKIKMAPPKTKYTDPILLGTTNER---DFGEIVNALEERINDSA-WTVVFKSLAVAHLM 66
AT P K +Y I + + R D ++AL R++ + W V K+L V H
Sbjct: 43 ATNHVERPSKERYIRAIFMAISATRPRADVAYCIHALARRLSRTHNWAVALKTLIVIHRA 102
Query: 67 IRDGDKDIALKYFSRNLDFFELRGLARSYPARSGDVQALDR----YRLYLKVRSEEYGKV 122
+R+ D+ + + + + ++ + A Y L+L+ R E + +
Sbjct: 103 LREVDQTFHEEVINYSRSRSHMLNMSHFKDDSGPNAWAYSAWVRFYALFLEERLECFRVL 162
Query: 123 RKDYVRNSNTNLKKFDDNRSSECLEHVESLELQIGALIKNRYSQCDLNNDLIMFAFKMLV 182
+ D + + D + + LE + +L+ + ++ + + N +I A M++
Sbjct: 163 KYDV----EVDPPRTKDLDTPDLLEQLPALQELLFRVLDCQPEGAAVQNHIIQLALSMVI 218
Query: 183 QDLLALYNALNEGIITLLESFFELTRSNAERTLKLYKRFVQLTENVVRYLKSAKAV---- 238
+ +Y AL +GI L++ FF++ R++A + L +Y+R V+ + + + K+V
Sbjct: 219 SESTKIYQALTDGIDNLVDKFFDMQRNDAVKALDMYRRAVKQAGRLSEFFEVCKSVNVGR 278
Query: 239 GLKIPVIKHITTKLINLLEDHLRE 262
G + I+ T + +E++++E
Sbjct: 279 GERFIKIEQPPTSFLQAMEEYVKE 302
>At1g03050 [TU] KOG0251 Clathrin assembly protein AP180 and related proteins
contain ENTH domain
Length = 599
Score = 61.2 bits (147), Expect = 4e-09
Identities = 66/321 (20%), Positives = 138/321 (42%), Gaps = 38/321 (11%)
Query: 11 ATKIKMAPPKTKYTDPILLGTTNERDF-GEIVNALEERINDS-AWTVVFKSLAVAHLMIR 68
AT+ + P + KY IL T+ R + V+ L R+N + WTV K+L + ++
Sbjct: 41 ATRHEEFPAEEKYIREILSLTSYSRSYINACVSTLSRRLNKTKCWTVALKTLILIQRLLG 100
Query: 69 DGDKDIALKYF------SRNLDFFELRGLARSYPARSGDVQALDR-YRLYLKVR------ 115
+GD+ + F +R L+ + R ++RS S D A R Y LYL R
Sbjct: 101 EGDQAYEQEIFFATRRGTRLLNMSDFRDVSRS---NSWDYSAFVRTYALYLDERLDFRMQ 157
Query: 116 ----------------SEEYGKVRKDYVRNSNTNLKKFDDNRSSECLEHVESLELQIGAL 159
EE + D + + ++ + ++ L+ +
Sbjct: 158 ARHGKRGVYCVGGEADEEEQDQAAADLSTAIVVRSQPIAEMKTEQIFIRIQHLQQLLDRF 217
Query: 160 IKNRYSQCDLNNDLIMFAFKMLVQDLLALYNALNEGIITLLESFFELTRSNAERTLKLYK 219
+ R + NN +++ A +V++ +Y + E + L+E F EL ++ + ++
Sbjct: 218 LACRPTGNARNNRVVIVALYPIVKESFQIYYDVTEIMGILIERFMELDIPDSIKVYDIFC 277
Query: 220 RFVQLTENVVRYLKSAKAVGL----KIPVIKHITTKLINLLEDHLREDTENKGNTFSKDD 275
R + E + ++ K +G+ + P I+ IT K ++L+++ +R+ + + SK
Sbjct: 278 RVSKQFEELDQFYSWCKNMGIARSSEYPEIEKITQKKLDLMDEFIRDKSALEHTKQSKSV 337
Query: 276 QTQVQSELERIRHQRIALENQ 296
+++ + + R + + E +
Sbjct: 338 KSEADEDDDEARTEEVNEEQE 358
>At4g02650_1 [TU] KOG0251 Clathrin assembly protein AP180 and related proteins
contain ENTH domain
Length = 555
Score = 54.7 bits (130), Expect = 4e-07
Identities = 75/336 (22%), Positives = 140/336 (41%), Gaps = 44/336 (13%)
Query: 1 MTTYHRLVKGATKIKMAPPKTKYTDPILLGTTNERDF-GEIVNALEERINDSA-WTVVFK 58
+T V AT+ P + KY IL T+ R++ V L R+N + W+V K
Sbjct: 31 LTELEIAVVKATRHDDYPAEDKYIREILCLTSYSRNYVSACVATLSRRLNKTKNWSVALK 90
Query: 59 SLAVAHLMIRDGDKDIALKYF------SRNLDFFELRGLARSYPARSGDVQALDR-YRLY 111
+L + ++ DGD+ + F +R L+ + R ++S S D A R Y LY
Sbjct: 91 TLILIQRLLTDGDRAYEQEIFFATRRGTRLLNMSDFRDASQS---DSWDYSAFVRTYALY 147
Query: 112 LKVRSEEYGKVRK-------------------DYVRNSN--------TNLKKFDDNRSSE 144
L R + + R+ D+ SN K + ++ +
Sbjct: 148 LDERLDYRMQGRRGKKKSGGGGGGDGDSGEEDDHRGTSNDIRSKAIVVKSKPVAEMKTEK 207
Query: 145 CLEHVESLELQIGALIKNRYSQCDLNNDLIMFAFKMLVQDLLALYNALNEGIITLLESFF 204
V+ L+ + + R + NN +++ A +V++ LY + E + L+E F
Sbjct: 208 IFNRVQHLQQLLDRFLACRPTGNAKNNRVVIVAMYPIVKESFQLYYNITEIMGVLIERFM 267
Query: 205 ELTRSNAERTLKLY----KRFVQLTENVVRYLKSAKAVGLKIPVIKHITTKLINLLEDHL 260
EL ++ + +++ K+F +L A A + P ++ IT K ++L+++ +
Sbjct: 268 ELDIHDSIKVYEIFCRVSKQFDELDPFYGWCKNMAVARSSEYPELEKITQKKLDLMDEFI 327
Query: 261 REDTENKGNTFSKDDQTQVQSELERIRHQRIALENQ 296
R+ + T + +SE E + + I ENQ
Sbjct: 328 RDKSALAAQTTKSSSKRSNKSEEEESKTEYIQ-ENQ 362
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.316 0.133 0.375
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,352,344
Number of Sequences: 60738
Number of extensions: 1080311
Number of successful extensions: 3817
Number of sequences better than 1.0e-05: 20
Number of HSP's better than 0.0 without gapping: 17
Number of HSP's successfully gapped in prelim test: 3
Number of HSP's that attempted gapping in prelim test: 3759
Number of HSP's gapped (non-prelim): 32
length of query: 567
length of database: 30,389,216
effective HSP length: 112
effective length of query: 455
effective length of database: 23,586,560
effective search space: 10731884800
effective search space used: 10731884800
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)