ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactI1752 check: MH U KOG4442 Intracellular trafficking, secretion, and vesicular transport Clathrin coat binding protein/Huntingtin interacting protein HIP1, involved in regulation of endocytosis
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactI1752 598118 596013 -702
(702 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YJL168c [U] KOG4442 Clathrin coat binding protein/Huntingtin int... 709 0.0
SPAC29B12.02c [U] KOG4442 Clathrin coat binding protein/Huntingt... 387 e-107
7292880 [U] KOG4442 Clathrin coat binding protein/Huntingtin int... 189 1e-47
Hs7661774 [U] KOG4442 Clathrin coat binding protein/Huntingtin i... 189 1e-47
At1g77300 [U] KOG4442 Clathrin coat binding protein/Huntingtin i... 173 9e-43
Hs13699811 [K] KOG1081 Transcription factor NSD1 and related SET... 166 1e-40
Hs19923586 [K] KOG1081 Transcription factor NSD1 and related SET... 163 7e-40
At1g76710 [U] KOG4442 Clathrin coat binding protein/Huntingtin i... 160 5e-39
Hs19913361 [K] KOG1081 Transcription factor NSD1 and related SET... 159 1e-38
Hs19913348 [K] KOG1081 Transcription factor NSD1 and related SET... 159 1e-38
CE08681 [U] KOG4442 Clathrin coat binding protein/Huntingtin int... 157 5e-38
Hs8922081 [K] KOG1083 Putative transcription factor ASH1/LIN-59 145 2e-34
At3g59960 [K] KOG1081 Transcription factor NSD1 and related SET ... 144 4e-34
7293772 [K] KOG1083 Putative transcription factor ASH1/LIN-59 142 2e-33
At2g44150 [K] KOG1081 Transcription factor NSD1 and related SET ... 141 3e-33
At4g30860 [K] KOG1081 Transcription factor NSD1 and related SET ... 133 1e-30
CE02822 [U] KOG4442 Clathrin coat binding protein/Huntingtin int... 131 3e-30
7301645 [K] KOG1081 Transcription factor NSD1 and related SET do... 130 7e-30
At2g23750 [BK] KOG1082 Histone H3 (Lys9) methyltransferase SUV39... 100 1e-20
7290222 [R] KOG4443 Putative transcription factor HALR/MLL3 invo... 98 5e-20
SPCC306.04c [BK] KOG1080 Histone H3 (Lys4) methyltransferase com... 97 1e-19
At5g42400 [BK] KOG1080 Histone H3 (Lys4) methyltransferase compl... 97 1e-19
Hs4507321 [BK] KOG1082 Histone H3 (Lys9) methyltransferase SUV39... 94 5e-19
7294815 [K] KOG1079 Transcriptional repressor EZH1 94 7e-19
Hs13375930 [BK] KOG1082 Histone H3 (Lys9) methyltransferase SUV3... 93 2e-18
CE27781 [K] KOG1081 Transcription factor NSD1 and related SET do... 89 2e-17
Hs21361095 [K] KOG1079 Transcriptional repressor EZH1 88 4e-17
YHR119w [BK] KOG1080 Histone H3 (Lys4) methyltransferase complex... 88 5e-17
CE27736 [BK] KOG1080 Histone H3 (Lys4) methyltransferase complex... 87 7e-17
CE27735 [BK] KOG1080 Histone H3 (Lys4) methyltransferase complex... 87 7e-17
CE01158 [BK] KOG1080 Histone H3 (Lys4) methyltransferase complex... 87 7e-17
Hs4505197 [R] KOG4443 Putative transcription factor HALR/MLL3 in... 86 2e-16
Hs19923202 [K] KOG1079 Transcriptional repressor EZH1 86 2e-16
HsM4758324 [K] KOG1079 Transcriptional repressor EZH1 86 3e-16
Hs22045532 [BK] KOG1082 Histone H3 (Lys9) methyltransferase SUV3... 85 3e-16
CE27623 [BK] KOG1082 Histone H3 (Lys9) methyltransferase SUV39H1... 85 3e-16
SPBC428.08c_2 [BK] KOG1082 Histone H3 (Lys9) methyltransferase S... 85 3e-16
Hs5730039_1 [BK] KOG1082 Histone H3 (Lys9) methyltransferase SUV... 85 3e-16
Hs5174569 [K] KOG1084 Transcription factor TCF20 84 7e-16
Hs22059579 [BK] KOG1080 Histone H3 (Lys4) methyltransferase comp... 83 1e-15
Hs10864041 [R] KOG4443 Putative transcription factor HALR/MLL3 i... 82 2e-15
ECU09g1750 [K] KOG1079 Transcriptional repressor EZH1 81 5e-15
CE16398 [R] KOG4443 Putative transcription factor HALR/MLL3 invo... 80 1e-14
7299982 [BK] KOG1082 Histone H3 (Lys9) methyltransferase SUV39H1... 79 2e-14
7289568 [BK] KOG1080 Histone H3 (Lys4) methyltransferase complex... 79 2e-14
At2g31630 [BK] KOG1080 Histone H3 (Lys4) methyltransferase compl... 79 3e-14
Hs7662046 [K] KOG1084 Transcription factor TCF20 78 4e-14
At4g02020 [K] KOG1079 Transcriptional repressor EZH1 78 5e-14
Hs21314722 [BK] KOG1082 Histone H3 (Lys9) methyltransferase SUV3... 77 7e-14
At1g05830_2 [BK] KOG1080 Histone H3 (Lys4) methyltransferase com... 77 9e-14
CE13601 [K] KOG1083 Putative transcription factor ASH1/LIN-59 77 1e-13
At2g23380 [K] KOG1079 Transcriptional repressor EZH1 76 2e-13
At2g22740_2 [BK] KOG1082 Histone H3 (Lys9) methyltransferase SUV... 75 3e-13
CE28067 [K] KOG1079 Transcriptional repressor EZH1 72 3e-12
Hs18426879 [BK] KOG1082 Histone H3 (Lys9) methyltransferase SUV3... 72 4e-12
Hs18375637 [BK] KOG1082 Histone H3 (Lys9) methyltransferase SUV3... 72 4e-12
At3g03750 [BK] KOG1082 Histone H3 (Lys9) methyltransferase SUV39... 72 4e-12
At5g53430 [BK] KOG1080 Histone H3 (Lys4) methyltransferase compl... 69 3e-11
At2g35160_2 [BK] KOG1082 Histone H3 (Lys9) methyltransferase SUV... 69 3e-11
CE09911 [BK] KOG1082 Histone H3 (Lys9) methyltransferase SUV39H1... 66 2e-10
CE08853 [BK] KOG1082 Histone H3 (Lys9) methyltransferase SUV39H1... 65 3e-10
7290020 [BK] KOG1082 Histone H3 (Lys9) methyltransferase SUV39H1... 65 3e-10
At1g17770_2 [BK] KOG1082 Histone H3 (Lys9) methyltransferase SUV... 62 2e-09
7299371 [BK] KOG1082 Histone H3 (Lys9) methyltransferase SUV39H1... 57 1e-07
At3g04380 [BK] KOG1082 Histone H3 (Lys9) methyltransferase SUV39... 56 2e-07
Hs20543055 [R] KOG1844 PHD Zn-finger proteins 54 6e-07
7299871 [R] KOG1085 Predicted methyltransferase (contains a SET ... 52 4e-06
CE25069 [B] KOG1141 Predicted histone methyl transferase 51 7e-06
>YJL168c [U] KOG4442 Clathrin coat binding protein/Huntingtin interacting
protein HIP1 involved in regulation of endocytosis
Length = 733
Score = 709 bits (1829), Expect = 0.0
Identities = 374/706 (52%), Positives = 466/706 (65%), Gaps = 38/706 (5%)
Query: 6 NGIVNTRQPKLFLDVPDMTSEAKKTYAELDVCTYTPKNLGDSKH-EFMECDCFEEFRDGL 64
N + +LF PD+T EA + LD C Y K +G K+ +FMECDC+EEF DG+
Sbjct: 19 NNAEGHKPQRLFDQEPDLTEEALTKFENLDDCIYANKRIGTFKNNDFMECDCYEEFSDGV 78
Query: 65 NHACGEDSDCINRATLIECVNGLCKHSCGTDCQNQRFQKKAYADISVFKTERKGFGVRAN 124
NHAC EDSDCINR TLIECVN LC SCG DCQNQRFQKK YA I++FKT+ KG+GVRA
Sbjct: 79 NHACDEDSDCINRLTLIECVNDLCS-SCGNDCQNQRFQKKQYAPIAIFKTKHKGYGVRAE 137
Query: 125 SDIEPHNFIYEYIGEVIQEEEFRNRMVKYDQMGFKHFYFMMLQTGQFIDATLKGCIARFC 184
DIE + FIYEY GEVI+E EFR+R++ YDQ FKHFYFMMLQ G+FIDAT+KG +ARFC
Sbjct: 138 QDIEANQFIYEYKGEVIEEMEFRDRLIDYDQRHFKHFYFMMLQNGEFIDATIKGSLARFC 197
Query: 185 NHSCNPNAYVNKWVVNGKLKMGIFANRHISKGEEVTFDYNVDRYGANAQPCYCEEPNCIG 244
NHSC+PNAYVNKWVV KL+MGIFA R I KGEE+TFDYNVDRYGA AQ CYCEEPNCIG
Sbjct: 198 NHSCSPNAYVNKWVVKDKLRMGIFAQRKILKGEEITFDYNVDRYGAQAQKCYCEEPNCIG 257
Query: 245 FLGGKTQTDAASLLPQSFADALGIRPSMEKKWINMMKAKGEKIAKSDTTTVNVDFVNSLS 304
FLGGKTQTDAASLLPQ+ ADALG+ SMEKKW+ + K GE I K++ +N++F+ SL
Sbjct: 258 FLGGKTQTDAASLLPQNIADALGVTVSMEKKWLKLKKLSGEPIIKNENENINIEFLQSLE 317
Query: 305 LEPCTKTEDVNRVMSVLLQIDDAFIAEKLLERITLTEDEAMHYQFIKLHGYLIFSRLITM 364
++P DV ++MSVLLQ D+ IA KLL+R+ +D+++ +Q IKLHGY FS+++ +
Sbjct: 318 VQPIDSPVDVTKIMSVLLQQDNKIIASKLLKRLFTIDDDSLRHQAIKLHGYTCFSKMLKL 377
Query: 365 F---------------EDKPDIIWKILNFLLVLPKTTKNGIIHSGIDKKVEQL-KNTPKF 408
F ED I IL+FLL LPKTT+NGI S ID V+ L P
Sbjct: 378 FITEQPQVDGKGNETEEDDIKFIKGILDFLLELPKTTRNGIESSQIDNVVKTLPAKFPFL 437
Query: 409 EVICEDLLEKWSKYETYTRISKKDIS-ENSKVIDLRRIRLPIGWEIIHENGRPVYYNAQR 467
+ C++LLEKWSK+ETY RI+KKDI+ SK+IDLRR+RLP GWEIIHENGRP+YYNA++
Sbjct: 438 KPNCDELLEKWSKFETYKRITKKDINVAASKMIDLRRVRLPPGWEIIHENGRPLYYNAEQ 497
Query: 468 QIKQANPPTDSAYRSNSSHNLSGVSDPKSRSATPSSNTSRYSGSVKYIPTPTYGQMQQKR 527
+ K PP+ S S+ + SNT S S IP +K
Sbjct: 498 KTKLHYPPSGS-----------------SKVFSSRSNTQVNSPSSSGIPKTPGALDSKKH 540
Query: 528 TLSPEEYEKRKKSRIEWEQKELELRKLMEQETLKAKLDQETQKKSELERIIEEANXXXXX 587
LS EEYE++K+ R+E+E+ LE K E E+LK KL E ++KS LE II E N
Sbjct: 541 KLSDEEYERKKQKRLEYERIALERAKQEELESLKQKLKLENERKSVLEDIIAEFNKQKEL 600
Query: 588 XXXXXXXXXXXXXXXXXXXXXASHVNAIENKWVKFFAQHVPNLIKN--YQKDVGKDVLKE 645
S +E+ W KFFA VPNLIK K + +K+
Sbjct: 601 QKEESKKLVEAKEAKRLKRKTVSQSQRLEHNWNKFFASFVPNLIKKNPQSKQFDHENIKQ 660
Query: 646 SARNIVKSLAQKELKKDSSRSPPEELSKEKRAKVKTFSMQYMDRLV 691
A++IVK L KELKKDSSR+PP++L+K KR KVK F YMD+++
Sbjct: 661 CAKDIVKILTTKELKKDSSRAPPDDLTKGKRHKVKEFINSYMDKII 706
>SPAC29B12.02c [U] KOG4442 Clathrin coat binding protein/Huntingtin interacting
protein HIP1 involved in regulation of endocytosis
Length = 798
Score = 387 bits (994), Expect = e-107
Identities = 251/731 (34%), Positives = 376/731 (51%), Gaps = 95/731 (12%)
Query: 14 PKLFLDVPDMTSEAKKTYAELDVCTYTPKNLGDS-KHEFMECDCFEEFRDGLNHACGEDS 72
P+LF + +A T+ E+ C Y N+G ++E M CDC + DG+N ACG S
Sbjct: 88 PQLFHHLDSAKDKALTTFEEIQECQYASANIGKPPENEAMICDCRPHWVDGVNVACGHGS 147
Query: 73 DCINRATLIECVNGLCKHSCGTDCQNQRFQKKAYADISVFKTERKGFGVRANSDIEPHNF 132
+CINR T IEC + + CG CQNQRFQ+ +A + VF TE+KGFG+RA++++ F
Sbjct: 148 NCINRMTSIECTDE--DNVCGPSCQNQRFQRHEFAKVDVFLTEKKGFGLRADANLPKDTF 205
Query: 133 IYEYIGEVIQEEEFRNRMVKYDQMGFKHFYFMMLQTGQFIDATLKGCIARFCNHSCNPNA 192
+YEYIGEVI E++FR RM +YD G KHFYFMMLQ G++IDAT +G +ARFCNHSC PN
Sbjct: 206 VYEYIGEVIPEQKFRKRMRQYDSEGIKHFYFMMLQKGEYIDATKRGSLARFCNHSCRPNC 265
Query: 193 YVNKWVVNGKLKMGIFANRHISKGEEVTFDYNVDRYGANAQPCYCEEPNCIGFLGGKTQT 252
YV+KW+V KL+MGIF R I +GEE+TFDYNVDRYGA AQPCYC EP C+G++GGKTQT
Sbjct: 266 YVDKWMVGDKLRMGIFCKRDIIRGEELTFDYNVDRYGAQAQPCYCGEPCCVGYIGGKTQT 325
Query: 253 DAASLLPQSFADALGIRPSMEKKWINMMKAKGEKIAKSDTTTVNVDFVNSLSLEPCTKTE 312
+A S LP++ +ALGI E W N+ + + D T+ ++ V L +E
Sbjct: 326 EAQSKLPENVREALGIEDE-EDSWENITARRQRRKKGIDETSKIIEEVQPTPL----TSE 380
Query: 313 DVNRVMSVLLQIDDAFIAEKLLERITLTEDEAMHYQFIKLHGYLIFSRLITMFEDKPDII 372
+V+ VLLQ D + KL+ERI LT D ++ I L GY IF ++ F + I
Sbjct: 381 SATKVIGVLLQTKDDLLTRKLMERIFLTSDPSVCRSIIALRGYNIFGLMLKKFSIDIEFI 440
Query: 373 WKILNFLLVLPKTTKNGIIHSGIDKKVEQLKNTPKFEV--ICEDLLEKWSKYETYTRISK 430
+ + +L P+ T+N I S I+ V++ + EV + LL++W E RI +
Sbjct: 441 LRSIKTMLSWPRLTRNKIQDSNIEPVVQEFCDHENEEVKDHAKTLLKEWESLEIAYRIPR 500
Query: 431 K------------DISENSKVIDLRRIRLPIGWEIIHENG--RPVYYNAQRQIKQANP-- 474
+ + S N LR G + G + N+ + + +P
Sbjct: 501 RKPGQVAPQSTNAEPSNNQSNPPLRDQEPQRG-----DKGDIKSAINNSTEDLSKKHPAL 555
Query: 475 ----PTDSA--------YRSNSSHNL-----------SGVSDPKSRSATPSSNTSRYSG- 510
P+DS Y+S+S HNL SD S + TP++ + S
Sbjct: 556 HSSRPSDSRSRSKFGNDYQSHSKHNLFRKNSFPKRRRLSNSDTPSETTTPNNEQEQVSNQ 615
Query: 511 ----SVKYIPTPTYGQMQQKRTLSPEEYEKRKKSRIEWEQKELELRKLMEQETLK--AKL 564
+ I + + QK L ++ E+ + + +QK E R+L +E+LK AK
Sbjct: 616 ANKVDLNKIISAAMESVNQKNVLKAQKEEEERIA----QQKREEKRRLAYEESLKRHAKK 671
Query: 565 DQETQKKSELERIIEEANXXXXXXXXXXXXXXXXXXXXXXXXXXASHVNAIENKWVKFFA 624
E + KS + I+ + A + KFFA
Sbjct: 672 LHEKKTKSSQDATIDH-----------------------HLTSHSPESIAFKAVLAKFFA 708
Query: 625 QHVPNLIKNYQKDVGKDVLKESARNIVKSLAQKELK---KDSSRSPPEELSKEKRAKVKT 681
N YQ+ +GK K + + + + +K ++ ++ P+ELS ++ K++
Sbjct: 709 ----NKTARYQEKLGKAEFKLRVKKMTEIILKKHIQLVLSKKEKALPDELSDSQQRKLRV 764
Query: 682 FSMQYMDRLVA 692
++ +Y+D +V+
Sbjct: 765 WAFRYLDTVVS 775
>7292880 [U] KOG4442 Clathrin coat binding protein/Huntingtin interacting
protein HIP1 involved in regulation of endocytosis
Length = 2362
Score = 189 bits (481), Expect = 1e-47
Identities = 105/242 (43%), Positives = 140/242 (57%), Gaps = 11/242 (4%)
Query: 23 MTSEAKKTYAELDVCTYTPKNLGDSKHEFMECDCF----EEFRDGLNHACGEDSDCINRA 78
+ SE T+ L Y ++ M+CDCF EE + L+ CG + CINR
Sbjct: 1330 LRSEGLNTFQLLKENFYRCARQVSQENAEMQCDCFLTGDEEAQGHLS--CG--AGCINRM 1385
Query: 79 TLIECVNGLCKHSCGTDCQNQRFQKKAYADISVFKTERKGFGVRANSDIEPHNFIYEYIG 138
+IEC LC + G C N+RFQ+ VF+TE+KG G+ A I P FI EY+G
Sbjct: 1386 LMIEC-GPLCSN--GARCTNKRFQQHQCWPCRVFRTEKKGCGITAELLIPPGEFIMEYVG 1442
Query: 139 EVIQEEEFRNRMVKYDQMGFKHFYFMMLQTGQFIDATLKGCIARFCNHSCNPNAYVNKWV 198
EVI EEF R Y + +H+YFM L+ IDAT KG I+R+ NHSC+PNA KW
Sbjct: 1443 EVIDSEEFERRQHLYSKDRNRHYYFMALRGEAVIDATSKGNISRYINHSCDPNAETQKWT 1502
Query: 199 VNGKLKMGIFANRHISKGEEVTFDYNVDRYGANAQPCYCEEPNCIGFLGGKTQTDAASLL 258
VNG+L++G F+ + I GEE+TFDY RYG +AQ CYCE NC G++GG+ +D L
Sbjct: 1503 VNGELRIGFFSVKPIQPGEEITFDYQYLRYGRDAQRCYCEAANCRGWIGGEPDSDEGEQL 1562
Query: 259 PQ 260
+
Sbjct: 1563 DE 1564
>Hs7661774 [U] KOG4442 Clathrin coat binding protein/Huntingtin interacting
protein HIP1 involved in regulation of endocytosis
Length = 591
Score = 189 bits (480), Expect = 1e-47
Identities = 123/378 (32%), Positives = 188/378 (49%), Gaps = 40/378 (10%)
Query: 38 TYTPKNLGDSKHEFMECDCFEEFRDGL---NHACGEDSDCINRATLIECVNGLCKHSCGT 94
T KN + M+C+C +D ACGED C+NR +IEC + C + G
Sbjct: 33 TERKKNKSHRDIKRMQCECTPLSKDKELKGEIACGED--CLNRLLMIEC-SSRCPN--GD 87
Query: 95 DCQNQRFQKKAYADISVFKTERKGFGVRANSDIEPHNFIYEYIGEVIQEEEFRNRMVKYD 154
C N+RFQ+K +AD+ V TE+KG+G+RA D+ + F+ EY GEV+ +EF+ R+ +Y
Sbjct: 88 YCSNRRFQRKQHADVEVILTEKKGWGLRAAKDLPSNTFVLEYCGEVLDHKEFKARVKEYA 147
Query: 155 QMGFKHFYFMMLQTGQFIDATLKGCIARFCNHSCNPNAYVNKWVVNGKLKMGIFANRHIS 214
+ H+YFM L+ + IDAT KG +RF NHSC PN KW VNG+L++G F + +
Sbjct: 148 RNKNIHYYFMALKNDEIIDATQKGNCSRFMNHSCEPNCETQKWTVNGQLRVGFFTTKLVP 207
Query: 215 KGEEVTFDYNVDRYGANAQPCYCEEPNCIGFLGGKTQTDAASLLPQSFADALGIRPSMEK 274
G E+TFDY RYG AQ C+C NC G+LGG+ +
Sbjct: 208 SGSELTFDYQFQRYGKEAQKCFCGSANCRGYLGGENR----------------------- 244
Query: 275 KWINMMKAKGEKIAKSDTTTVNVDFVNSLSLEPCTKTEDVNRVMSV-LLQIDDAFIAEKL 333
+++ A G+ + VD +E D N+V+S+ L + + +KL
Sbjct: 245 --VSIRAAGGKMKNERSRRGFKVDGELEALMENGEGLSDKNQVLSLSRLMVRIETLEQKL 302
Query: 334 --LERITLTEDEAMHYQFIKLHG----YLIFSRLITMFEDKPDIIWKILNFLLVLPKTTK 387
LE I T ++ F++ HG ++ + L E + +I+ L LP TK
Sbjct: 303 TCLELIQNTHSQSCLKSFLERHGLSLLWIWMAELGDGRESNQKLQEEIIKTLEHLPIPTK 362
Query: 388 NGIIHSGIDKKVEQLKNT 405
N + S + +++ T
Sbjct: 363 NMLEESKVLPIIQRWSQT 380
>At1g77300 [U] KOG4442 Clathrin coat binding protein/Huntingtin interacting
protein HIP1 involved in regulation of endocytosis
Length = 408
Score = 173 bits (438), Expect = 9e-43
Identities = 86/198 (43%), Positives = 120/198 (60%), Gaps = 7/198 (3%)
Query: 52 MECDCFEEFRDGLNHACGEDSDCINRATLIECVNGLCKHSCGTDCQNQRFQKKAYADISV 111
M C C + DG CGE+ C+NR IEC+ G C G C NQ+FQK+ Y
Sbjct: 1 MVCHC-KPSPDG-RLGCGEE--CLNRMLNIECLQGTCP--AGDLCSNQQFQKRKYVKFER 54
Query: 112 FKTERKGFGVRANSDIEPHNFIYEYIGEVIQEEEFRNRMVKYDQMGFKHFYFMMLQTGQF 171
F++ +KG+G+R D+ F+ EY+GEV+ + + R +Y G KHFYFM L +
Sbjct: 55 FQSGKKGYGLRLLEDVREGQFLIEYVGEVLDMQSYETRQKEYAFKGQKHFYFMTLNGNEV 114
Query: 172 IDATLKGCIARFCNHSCNPNAYVNKWVVNGKLKMGIFANRHISKGEEVTFDYNVDR-YGA 230
IDA KG + RF NHSC PN KW+VNG++ +GIF+ + + KG+E+TFDYN R +GA
Sbjct: 115 IDAGAKGNLGRFINHSCEPNCRTEKWMVNGEICVGIFSMQDLKKGQELTFDYNYVRVFGA 174
Query: 231 NAQPCYCEEPNCIGFLGG 248
A+ CYC +C G++GG
Sbjct: 175 AAKKCYCGSSHCRGYIGG 192
>Hs13699811 [K] KOG1081 Transcription factor NSD1 and related SET domain proteins
Length = 1437
Score = 166 bits (419), Expect = 1e-40
Identities = 83/207 (40%), Positives = 118/207 (56%), Gaps = 6/207 (2%)
Query: 50 EFMECDCFEEFRDGLNHACGEDSDCINRATLIECVNGLCKHSCGTDCQNQRFQKKAYADI 109
E C+C + + CG +S+C+NR EC +C G CQNQ F K+ Y D
Sbjct: 1094 EIPRCNC----KPADENPCGLESECLNRMLQYECHPQVCP--AGDRCQNQCFTKRLYPDA 1147
Query: 110 SVFKTERKGFGVRANSDIEPHNFIYEYIGEVIQEEEFRNRMVKYDQMGFKHFYFMMLQTG 169
+ KTER+G+G+R I+ F+ EY+GE+I EEE R R+ + + +FY + +
Sbjct: 1148 EIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKD 1207
Query: 170 QFIDATLKGCIARFCNHSCNPNAYVNKWVVNGKLKMGIFANRHISKGEEVTFDYNVDRYG 229
+ IDA KG +RF NHSCNPN KW VNG +++G+FA I G E+TF+YN+D G
Sbjct: 1208 RIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYNLDCLG 1267
Query: 230 ANAQPCYCEEPNCIGFLGGKTQTDAAS 256
C+C NC GFLG + ++ AS
Sbjct: 1268 NGRTECHCGADNCSGFLGVRPKSACAS 1294
>Hs19923586 [K] KOG1081 Transcription factor NSD1 and related SET domain proteins
Length = 2696
Score = 163 bits (413), Expect = 7e-40
Identities = 82/198 (41%), Positives = 113/198 (56%), Gaps = 6/198 (3%)
Query: 50 EFMECDCFEEFRDGLNHACGEDSDCINRATLIECVNGLCKHSCGTDCQNQRFQKKAYADI 109
E C+C + + CG DS+CINR L EC +C G CQNQ F K+ Y ++
Sbjct: 1891 EIPRCNC----KATDENPCGIDSECINRMLLYECHPTVCP--AGGRCQNQCFSKRQYPEV 1944
Query: 110 SVFKTERKGFGVRANSDIEPHNFIYEYIGEVIQEEEFRNRMVKYDQMGFKHFYFMMLQTG 169
+F+T ++G+G+R +DI+ F+ EY+GE+I EEE R R+ + +FY + L
Sbjct: 1945 EIFRTLQRGWGLRTKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDKD 2004
Query: 170 QFIDATLKGCIARFCNHSCNPNAYVNKWVVNGKLKMGIFANRHISKGEEVTFDYNVDRYG 229
+ IDA KG ARF NH C PN KW VNG ++G+FA I G E+TF+YN++ G
Sbjct: 2005 RIIDAGPKGNYARFMNHCCQPNCETQKWSVNGDTRVGLFALSDIKAGTELTFNYNLECLG 2064
Query: 230 ANAQPCYCEEPNCIGFLG 247
C C PNC GFLG
Sbjct: 2065 NGKTVCKCGAPNCSGFLG 2082
>At1g76710 [U] KOG4442 Clathrin coat binding protein/Huntingtin interacting
protein HIP1 involved in regulation of endocytosis
Length = 528
Score = 160 bits (406), Expect = 5e-39
Identities = 88/215 (40%), Positives = 118/215 (53%), Gaps = 5/215 (2%)
Query: 42 KNLGDSKHEFMECDCFEEFRDGLNHACGEDSDCINRATLIECVNGLCKHSCGTDCQNQRF 101
K+ + + C+C +F D + ACGE C+N T EC G C CG C+NQ+F
Sbjct: 29 KHKKQKEEDISICECKFDFGDP-DSACGER--CLNVITNTECTPGYCP--CGVYCKNQKF 83
Query: 102 QKKAYADISVFKTERKGFGVRANSDIEPHNFIYEYIGEVIQEEEFRNRMVKYDQMGFKHF 161
QK YA + K E +G+G+ A +I+ FI EY GEVI +E + R Y+ G K
Sbjct: 84 QKCEYAKTKLIKCEGRGWGLVALEEIKAGQFIMEYCGEVISWKEAKKRAQTYETHGVKDA 143
Query: 162 YFMMLQTGQFIDATLKGCIARFCNHSCNPNAYVNKWVVNGKLKMGIFANRHISKGEEVTF 221
Y + L + IDAT KG +ARF NHSC PN KW V G++++GIFA IS E+ +
Sbjct: 144 YIISLNASEAIDATKKGSLARFINHSCRPNCETRKWNVLGEVRVGIFAKESISPRTELAY 203
Query: 222 DYNVDRYGANAQPCYCEEPNCIGFLGGKTQTDAAS 256
DYN + YG C C C GFLG K++ AS
Sbjct: 204 DYNFEWYGGAKVRCLCGAVACSGFLGAKSRGFQAS 238
>Hs19913361 [K] KOG1081 Transcription factor NSD1 and related SET domain
proteins
Length = 584
Score = 159 bits (403), Expect = 1e-38
Identities = 88/242 (36%), Positives = 124/242 (50%), Gaps = 14/242 (5%)
Query: 50 EFMECDCFEEFRDGLNHACGEDSDCINRATLIECVNGLCKHSCGTDCQNQRFQKKAYADI 109
E +C+C + + CG DS+C+NR + EC +C G CQNQ F K+ Y +
Sbjct: 231 EIPKCNC----KPTDENPCGFDSECLNRMLMFECHPQVCP--AGEFCQNQCFTKRQYPET 284
Query: 110 SVFKTERKGFGVRANSDIEPHNFIYEYIGEVIQEEEFRNRMVKYDQMGFKHFYFMMLQTG 169
+ KT+ KG+G+ A DI F+ EY+GE+I EEE R+ + HFY + +
Sbjct: 285 KIIKTDGKGWGLVAKRDIRKGEFVNEYVGELIDEEECMARIKHAHENDITHFYMLTIDKD 344
Query: 170 QFIDATLKGCIARFCNHSCNPNAYVNKWVVNGKLKMGIFANRHISKGEEVTFDYNVDRYG 229
+ IDA KG +RF NHSC PN KW VNG ++G+FA I G E+TF+YN+D G
Sbjct: 345 RIIDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAGTELTFNYNLDCLG 404
Query: 230 ANAQPCYCEEPNCIGFLGGKTQTDAASLLPQSFADALGIRPSMEKKWINMMKAKGEKIAK 289
C C NC GFLG + +T + + KK +AKGE +
Sbjct: 405 NEKTVCRCGASNCSGFLGDRPKTSTTLSSEE--------KGKKTKKKTRRRRAKGEGKRQ 456
Query: 290 SD 291
S+
Sbjct: 457 SE 458
>Hs19913348 [K] KOG1081 Transcription factor NSD1 and related SET domain proteins
Length = 1365
Score = 159 bits (403), Expect = 1e-38
Identities = 88/242 (36%), Positives = 124/242 (50%), Gaps = 14/242 (5%)
Query: 50 EFMECDCFEEFRDGLNHACGEDSDCINRATLIECVNGLCKHSCGTDCQNQRFQKKAYADI 109
E +C+C + + CG DS+C+NR + EC +C G CQNQ F K+ Y +
Sbjct: 1012 EIPKCNC----KPTDENPCGFDSECLNRMLMFECHPQVCP--AGEFCQNQCFTKRQYPET 1065
Query: 110 SVFKTERKGFGVRANSDIEPHNFIYEYIGEVIQEEEFRNRMVKYDQMGFKHFYFMMLQTG 169
+ KT+ KG+G+ A DI F+ EY+GE+I EEE R+ + HFY + +
Sbjct: 1066 KIIKTDGKGWGLVAKRDIRKGEFVNEYVGELIDEEECMARIKHAHENDITHFYMLTIDKD 1125
Query: 170 QFIDATLKGCIARFCNHSCNPNAYVNKWVVNGKLKMGIFANRHISKGEEVTFDYNVDRYG 229
+ IDA KG +RF NHSC PN KW VNG ++G+FA I G E+TF+YN+D G
Sbjct: 1126 RIIDAGPKGNYSRFMNHSCQPNCETLKWTVNGDTRVGLFAVCDIPAGTELTFNYNLDCLG 1185
Query: 230 ANAQPCYCEEPNCIGFLGGKTQTDAASLLPQSFADALGIRPSMEKKWINMMKAKGEKIAK 289
C C NC GFLG + +T + + KK +AKGE +
Sbjct: 1186 NEKTVCRCGASNCSGFLGDRPKTSTTLSSEE--------KGKKTKKKTRRRRAKGEGKRQ 1237
Query: 290 SD 291
S+
Sbjct: 1238 SE 1239
>CE08681 [U] KOG4442 Clathrin coat binding protein/Huntingtin interacting
protein HIP1 involved in regulation of endocytosis
Length = 1590
Score = 157 bits (397), Expect = 5e-38
Identities = 90/219 (41%), Positives = 122/219 (55%), Gaps = 18/219 (8%)
Query: 39 YTPKNLGDSKHEFMECDCFEEFRDGLNHACGEDSDCINRATLIECVNGLCKHSCGTDCQN 98
Y +N K E + C+C R G N + D+ C+NRA L EC + SC C+N
Sbjct: 612 YLTRNANKKKTESLTCECH---RTGGNCS---DNTCVNRAMLTECPS-----SCQVKCKN 660
Query: 99 QRFQKKAYADISVFKT-ERKGFGVRANSDIEPHNFIYEYIGEVIQEEEFRNRMVKYDQMG 157
QRF KK YA + F T KG G+RA DI+ FI EYIGEV++ +++ R KY
Sbjct: 661 QRFAKKKYAAVEAFHTGTAKGCGLRAVKDIKKGRFIIEYIGEVVERDDYEKRKTKY-AAD 719
Query: 158 FKHFYFMMLQTGQF-IDATLKGCIARFCNHSCNPNAYVNKWVV----NGKLKMGIFANRH 212
KH + + TG + IDAT+ G +RF NHSC+PNA KW V ++G F+ R
Sbjct: 720 KKHKHHYLCDTGVYTIDATVYGNPSRFVNHSCDPNAICEKWSVPRTPGDVNRVGFFSKRF 779
Query: 213 ISKGEEVTFDYNVDRYGANAQPCYCEEPNCIGFLGGKTQ 251
I GEE+TFDY YG +AQ C+C +C G++G K +
Sbjct: 780 IKAGEEITFDYQFVNYGRDAQQCFCGSASCSGWIGQKPE 818
>Hs8922081 [K] KOG1083 Putative transcription factor ASH1/LIN-59
Length = 2969
Score = 145 bits (366), Expect = 2e-34
Identities = 88/275 (32%), Positives = 139/275 (50%), Gaps = 16/275 (5%)
Query: 47 SKHEFMECDCFEEFRDGLNHACGEDSDCINRATLIECVNGLCKHSCGTDCQNQRFQKKAY 106
S +E C+C ++ D C +D C+NR EC C CG C NQR Q+ +
Sbjct: 2089 SGYEATTCNC-KKPDDDTRKGCVDD--CLNRMIFAECSPNTCP--CGEQCCNQRIQRHEW 2143
Query: 107 AD-ISVFKTERKGFGVRANSDIEPHNFIYEYIGEVIQEEEFRNRMVKYDQMGFKHFYFMM 165
+ F+ E KG+G+R ++ FI EY+GEV+ E+EFRNRM++ H Y +
Sbjct: 2144 VQCLERFRAEEKGWGIRTKEPLKAGQFIIEYLGEVVSEQEFRNRMIEQYHNHSDH-YCLN 2202
Query: 166 LQTGQFIDATLKGCIARFCNHSCNPNAYVNKWVVNGKLKMGIFANRHISKGEEVTFDYNV 225
L +G ID+ G ARF NHSC+PN + KW VNG ++G++A + + G E+T+DYN
Sbjct: 2203 LDSGMVIDSYRMGNEARFINHSCDPNCEMQKWSVNGVYRIGLYALKDMPAGTELTYDYNF 2262
Query: 226 DRYGANAQP-CYCEEPNCIGFLGGKTQ-----TDAASLLPQSFADALGIRPSMEKKWINM 279
+ Q C C C G +GGK+Q T + + P + G R ++K +
Sbjct: 2263 HSFNVEKQQLCKCGFEKCRGIIGGKSQRVNGLTSSKNSQPMATHKKSG-RSKEKRKSKHK 2321
Query: 280 MKAKGEKIAKSDTTTVNVD--FVNSLSLEPCTKTE 312
+K + +++ + +N L ++P + E
Sbjct: 2322 LKKRRGHLSEEPSENINTPTRLTPQLQMKPMSNRE 2356
>At3g59960 [K] KOG1081 Transcription factor NSD1 and related SET domain
proteins
Length = 352
Score = 144 bits (364), Expect = 4e-34
Identities = 80/233 (34%), Positives = 127/233 (54%), Gaps = 11/233 (4%)
Query: 18 LDVPDMTSEAKKTYAELDVCTYTPKNLGDS-KHEFMECDCFEEFRDGLNHACGEDSDCIN 76
L+ PD + K + + ++ Y K L K + C C G + CG D +C
Sbjct: 30 LESPDRLNNVKPIFIKRNI--YLKKKLKKKVKDHGIFCSC--SLDPGSSTLCGSDCNC-- 83
Query: 77 RATLIECVNGLCKHSCGTDCQNQRFQKKAYADISVFKTERKGFGVRANSDIEPHNFIYEY 136
L+ + CK C ++C N+ FQ++ + + +TE+ G+G+ A+ DI FI EY
Sbjct: 84 -GILLSSCSSSCK--CSSECTNKPFQQRHIKKMKLVQTEKCGYGIVADEDINSGEFIIEY 140
Query: 137 IGEVIQEEEFRNRMVKYDQMGFKHFYFMMLQTGQFIDATLKGCIARFCNHSCNPNAYVNK 196
+GEVI ++ R+ K + +FY + IDAT KG +R+ NHSC+PN + K
Sbjct: 141 VGEVIDDKICEERLWKLNHKVETNFYLCQINWNMVIDATHKGNKSRYINHSCSPNTEMQK 200
Query: 197 WVVNGKLKMGIFANRHISKGEEVTFDYNVDRYGANAQPCYCEEPNCIGFLGGK 249
W+++G+ ++GIFA R I+KGE++T+DY ++GA+ Q CYC C LG K
Sbjct: 201 WIIDGETRIGIFATRFINKGEQLTYDYQFVQFGAD-QDCYCGAVCCRKKLGAK 252
>7293772 [K] KOG1083 Putative transcription factor ASH1/LIN-59
Length = 2167
Score = 142 bits (358), Expect = 2e-33
Identities = 75/181 (41%), Positives = 99/181 (54%), Gaps = 5/181 (2%)
Query: 73 DCINRATLIECVNGLCKHSCGTDCQNQRFQKKAYAD-ISVFKTERKGFGVRANSDIEPHN 131
+C+NR EC C G C+NQ+ Q+ A A + F T KG+GVR I
Sbjct: 1298 NCLNRMVYTECSPSNCP--AGEKCRNQKIQRHAVAPGVERFMTADKGWGVRTKLPIAKGT 1355
Query: 132 FIYEYIGEVIQEEEFRNRMVKYDQMGFKHFYFMMLQTGQFIDATLKGCIARFCNHSCNPN 191
+I EY+GEV+ E+EF+ RM + H Y + L G ID G RF NHSC PN
Sbjct: 1356 YILEYVGEVVTEKEFKQRMASI-YLNDTHHYCLHLDGGLVIDGQRMGSDCRFVNHSCEPN 1414
Query: 192 AYVNKWVVNGKLKMGIFANRHISKGEEVTFDYNVDRYG-ANAQPCYCEEPNCIGFLGGKT 250
+ KW VNG +M +FA R I +GEE+T+DYN + + QPC C P C G +GGK+
Sbjct: 1415 CEMQKWSVNGLSRMVLFAKRAIEEGEELTYDYNFSLFNPSEGQPCRCNTPQCRGVIGGKS 1474
Query: 251 Q 251
Q
Sbjct: 1475 Q 1475
>At2g44150 [K] KOG1081 Transcription factor NSD1 and related SET domain
proteins
Length = 344
Score = 141 bits (356), Expect = 3e-33
Identities = 72/196 (36%), Positives = 107/196 (53%), Gaps = 6/196 (3%)
Query: 54 CDCFEEFRDGLNHACGEDSDCINRATLIECVNGLCKHSCGTDCQNQRFQKKAYADISVFK 113
C C + CG + C L + CK CG++C N+ FQ++ + + +
Sbjct: 68 CSCSSSSPGSSSTVCGSNCHC---GMLFSSCSSSCK--CGSECNNKPFQQRHVKKMKLIQ 122
Query: 114 TERKGFGVRANSDIEPHNFIYEYIGEVIQEEEFRNRMVKYDQMGFKHFYFMMLQTGQFID 173
TE+ G G+ A +IE FI EY+GEVI ++ R+ K G +FY + ID
Sbjct: 123 TEKCGSGIVAEEEIEAGEFIIEYVGEVIDDKTCEERLWKMKHRGETNFYLCEITRDMVID 182
Query: 174 ATLKGCIARFCNHSCNPNAYVNKWVVNGKLKMGIFANRHISKGEEVTFDYNVDRYGANAQ 233
AT KG +R+ NHSCNPN + KW+++G+ ++GIFA R I KGE +T+DY ++GA+ Q
Sbjct: 183 ATHKGNKSRYINHSCNPNTQMQKWIIDGETRIGIFATRGIKKGEHLTYDYQFVQFGAD-Q 241
Query: 234 PCYCEEPNCIGFLGGK 249
C+C C LG K
Sbjct: 242 DCHCGAVGCRRKLGVK 257
>At4g30860 [K] KOG1081 Transcription factor NSD1 and related SET domain
proteins
Length = 477
Score = 133 bits (334), Expect = 1e-30
Identities = 68/159 (42%), Positives = 90/159 (55%), Gaps = 3/159 (1%)
Query: 91 SCGTDCQNQRFQKKAYADISVFKTERKGFGVRANSDIEPHNFIYEYIGEVIQEEEFRNRM 150
SC C N+ F+K+ I + KTE G+GV A I +FI EYIGEVI + + R+
Sbjct: 292 SCPESCGNRPFRKEK--KIKIVKTEHCGWGVEAAESINKEDFIVEYIGEVISDAQCEQRL 349
Query: 151 VKYDQMGFKHFYFMMLQTGQFIDATLKGCIARFCNHSCNPNAYVNKWVVNGKLKMGIFAN 210
G K FY +Q IDAT KG +RF NHSCNPN + KW V G+ ++G+FA
Sbjct: 350 WDMKHKGMKDFYMCEIQKDFTIDATFKGNASRFLNHSCNPNCVLEKWQVEGETRVGVFAA 409
Query: 211 RHISKGEEVTFDYNVDRYGANAQPCYCEEPNCIGFLGGK 249
R I GE +T+DY ++G + C C NC G+LG K
Sbjct: 410 RQIEAGEPLTYDYRFVQFGPEVK-CNCGSENCQGYLGTK 447
>CE02822 [U] KOG4442 Clathrin coat binding protein/Huntingtin interacting
protein HIP1 involved in regulation of endocytosis
Length = 408
Score = 131 bits (330), Expect = 3e-30
Identities = 80/215 (37%), Positives = 111/215 (51%), Gaps = 21/215 (9%)
Query: 68 CGED---SDCINRATLIECVNGLCKHSCGTDCQNQRFQKKAYADISVFKTERK-GFGVRA 123
CG D +C N A EC G ++C+NQRF+K+ + + F T+ G G+RA
Sbjct: 59 CGTDCTTEECSNFANHRECPRGC------SNCENQRFRKRQFCGVETFLTDNGIGHGLRA 112
Query: 124 NSDIEPHNFIYEYIGEVIQEEEFRNRMVKYDQMGFKHFYFMMLQTGQFIDATLKGCIARF 183
+I I EY GE I + E R+ +Y + G KH Y + ++D T KG ARF
Sbjct: 113 TEEIATGKLILEYRGEAITKAEHNKRVKRYKKDGIKHSYSFEVGRNYYVDPTRKGNSARF 172
Query: 184 CNHSCNPNAYVNKWVVNGK--LKMGIFANRHISKGEEVTFDYNVDRYGANAQPCYCEEPN 241
NHSCNPNA V W V + +GIFA++ I GEE+TFDY N QPC C E
Sbjct: 173 INHSCNPNALVKVWTVPDRPMKSLGIFASKVIKPGEEITFDYGTS--FRNDQPCQCGEAA 230
Query: 242 CIGFLGGKTQTDAASLLPQSFADAL---GIRPSME 273
C G++G + S +P+ + L G +P M+
Sbjct: 231 CRGWIG----KPSTSEVPKDVSKELKKRGRKPKMD 261
>7301645 [K] KOG1081 Transcription factor NSD1 and related SET domain proteins
Length = 1401
Score = 130 bits (327), Expect = 7e-30
Identities = 71/210 (33%), Positives = 108/210 (50%), Gaps = 7/210 (3%)
Query: 41 PKNLGDSKHEFMECDCFEEFRDGLNHACGEDSDCINRATLIECVNGLCKHSCGTDCQNQR 100
P + + C+C H CG ++ C+NR EC CK G+ C+N+
Sbjct: 1174 PLRFSQNLEDLSTCNCLPVDE----HPCGPEAGCLNRMLFNECNPEYCK--AGSLCENRM 1227
Query: 101 FQKKAYADISVFKTERKGFGVRANSDIEPHNFIYEYIGEVIQEEEFRNRMVKYDQMGFKH 160
F+++ + V +GFG+ I +F+ EY+GEVI EF+ RM + + ++
Sbjct: 1228 FEQRKSPRLEVVYMNERGFGLVNREPIAVGDFVIEYVGEVINHAEFQRRMEQKQRDRDEN 1287
Query: 161 FYFMMLQTGQFIDATLKGCIARFCNHSCNPNAYVNKWVVNGKLKMGIFANRHISKGEEVT 220
+YF+ ++ IDA KG +ARF NHSC PN KW VN ++GIFA + I E+T
Sbjct: 1288 YYFLGVEKDFIIDAGPKGNLARFMNHSCEPNCETQKWTVNCIHRVGIFAIKDIPVNSELT 1347
Query: 221 FDYNVDRYGANA-QPCYCEEPNCIGFLGGK 249
F+Y D N+ + C+C C G +GGK
Sbjct: 1348 FNYLWDDLMNNSKKACFCGAKRCSGEIGGK 1377
>At2g23750 [BK] KOG1082 Histone H3 (Lys9) methyltransferase SUV39H1/Clr4
required for transcriptional silencing
Length = 203
Score = 99.8 bits (247), Expect = 1e-20
Identities = 64/183 (34%), Positives = 89/183 (47%), Gaps = 21/183 (11%)
Query: 82 ECVNGLCKHSCGTDCQNQRFQKKAYADISVFKTERKGFGVRANSDIEPHNFIYEYIGEVI 141
EC N C C CQN+ Q A + VF+TE KG+G+RA I F+ EYIGEV+
Sbjct: 23 EC-NKFC--GCSRTCQNRVLQNGIRAKLEVFRTESKGWGLRACEHILRGTFVCEYIGEVL 79
Query: 142 QEEEFRNRMVKYDQMGFKHFY-----------FMMLQTGQFIDATLKGCIARFCNHSCNP 190
++E R +Y + M + IDAT G I+RF NHSC+P
Sbjct: 80 DQQEANKRRNQYGNGDCSYILDIDANINDIGRLMEEELDYAIDATTHGNISRFINHSCSP 139
Query: 191 NAYVNKWVVNGK----LKMGIFANRHISKGEEVTFDYN---VDRYGANAQPCYCEEPNCI 243
N ++ +V +G++A+ I+ GEE+T DY V N PC+C+ NC
Sbjct: 140 NLVNHQVIVESMESPLAHIGLYASMDIAAGEEITRDYGRRPVPSEQENEHPCHCKATNCR 199
Query: 244 GFL 246
G L
Sbjct: 200 GLL 202
>7290222 [R] KOG4443 Putative transcription factor HALR/MLL3 involved in
embryonic development
Length = 2304
Score = 97.8 bits (242), Expect = 5e-20
Identities = 53/147 (36%), Positives = 84/147 (57%), Gaps = 2/147 (1%)
Query: 97 QNQRFQKKAYADISVFKTERKGFGVRANSDIEPHNFIYEYIGEVIQEEEFRNRMVKYDQM 156
Q ++ +++ ++ + +++ +G G+ A DIE H I EYIGEVI+ E R +Y+
Sbjct: 2154 QYKKMKQEWRNNVYLARSKIQGLGLYAARDIEKHTMIIEYIGEVIRTEVSEIREKQYESK 2213
Query: 157 GFKHFYFMMLQTGQFIDATLKGCIARFCNHSCNPNAYVNKWVVNGKLKMGIFANRHISKG 216
+ Y L + +DATL G +AR+ NHSCNPN V+ +++ IFA R I +G
Sbjct: 2214 N-RGIYMFRLDEDRVVDATLSGGLARYINHSCNPNCVTEIVEVDRDVRIIIFAKRKIYRG 2272
Query: 217 EEVTFDYNVD-RYGANAQPCYCEEPNC 242
EE+++DY D ++ PC C PNC
Sbjct: 2273 EELSYDYKFDIEDESHKIPCACGAPNC 2299
>SPCC306.04c [BK] KOG1080 Histone H3 (Lys4) methyltransferase complex subunit
SET1 and related methyltransferases
Length = 920
Score = 96.7 bits (239), Expect = 1e-19
Identities = 60/187 (32%), Positives = 88/187 (46%), Gaps = 3/187 (1%)
Query: 62 DGLNHACGEDSDCINRATLIECVNGLCKHSCGTDCQNQRFQ--KKAYADISVFKTERKGF 119
D ++H+ + +NR G+ K + RF K + +
Sbjct: 734 DTISHSTSRITSRMNRVNNRRLAAGVEKSQLPAEADLLRFNALKARKKQLHFGPSRIHTL 793
Query: 120 GVRANSDIEPHNFIYEYIGEVIQEEEFRNRMVKYDQMGFKHFYFMMLQTGQFIDATLKGC 179
G+ A +I+ ++ + EYIGE+I++ NR Y + G Y + +DAT KG
Sbjct: 794 GLFAMENIDKNDMVIEYIGEIIRQRVADNREKNYVREGIGDSYLFRIDEDVIVDATKKGN 853
Query: 180 IARFCNHSCNPNAYVNKWVVNGKLKMGIFANRHISKGEEVTFDYNVDRYGANAQPCYCEE 239
IARF NHSC PN V GK K+ I+A+R I GEE+T+DY A+ PC C
Sbjct: 854 IARFINHSCAPNCIARIIRVEGKRKIVIYADRDIMHGEELTYDYKFPE-EADKIPCLCGA 912
Query: 240 PNCIGFL 246
P C G+L
Sbjct: 913 PTCRGYL 919
>At5g42400 [BK] KOG1080 Histone H3 (Lys4) methyltransferase complex subunit SET1
and related methyltransferases
Length = 1421
Score = 96.7 bits (239), Expect = 1e-19
Identities = 51/127 (40%), Positives = 70/127 (54%), Gaps = 1/127 (0%)
Query: 119 FGVRANSDIEPHNFIYEYIGEVIQEEEFRNRMVKYDQMGFKHFYFMMLQTGQFIDATLKG 178
+G+ A IE +F+ EY+GE+I+ R +Y++MG Y L G +DAT +G
Sbjct: 1276 WGLVALEPIEAEDFVIEYVGELIRSSISEIRERQYEKMGIGSSYLFRLDDGYVLDATKRG 1335
Query: 179 CIARFCNHSCNPNAYVNKWVVNGKLKMGIFANRHISKGEEVTFDYNVDRYGANAQPCYCE 238
IARF NHSC PN Y V GK K+ I+A RHI GEE++++Y + PC C
Sbjct: 1336 GIARFINHSCEPNCYTKIISVEGKKKIFIYAKRHIDAGEEISYNYKFP-LEDDKIPCNCG 1394
Query: 239 EPNCIGF 245
PN F
Sbjct: 1395 APNVYCF 1401
>Hs4507321 [BK] KOG1082 Histone H3 (Lys9) methyltransferase SUV39H1/Clr4
required for transcriptional silencing
Length = 412
Score = 94.4 bits (233), Expect = 5e-19
Identities = 57/152 (37%), Positives = 86/152 (56%), Gaps = 9/152 (5%)
Query: 80 LIECVNGLCKHSCGTDCQNQRFQKKAYADISVFKTER-KGFGVRANSDIEPHNFIYEYIG 138
+ EC N C+ CG DC N+ QK D+ +F+T+ +G+GVR I ++F+ EY+G
Sbjct: 219 IYEC-NSRCR--CGYDCPNRVVQKGIRYDLCIFRTDDGRGWGVRTLEKIRKNSFVMEYVG 275
Query: 139 EVIQEEEFRNRMVKYDQMGFKHFYFM-MLQTGQFIDATLKGCIARFCNHSCNPNAYV-NK 196
E+I EE R YD+ G + + + ++ +DA G I+ F NHSC+PN V N
Sbjct: 276 EIITSEEAERRGQIYDRQGATYLFDLDYVEDVYTVDAAYYGNISHFVNHSCDPNLQVYNV 335
Query: 197 WVVN---GKLKMGIFANRHISKGEEVTFDYNV 225
++ N ++ FA R I GEE+TFDYN+
Sbjct: 336 FIDNLDERLPRIAFFATRTIRAGEELTFDYNM 367
>7294815 [K] KOG1079 Transcriptional repressor EZH1
Length = 760
Score = 94.0 bits (232), Expect = 7e-19
Identities = 71/234 (30%), Positives = 103/234 (43%), Gaps = 34/234 (14%)
Query: 26 EAKKTYAELDVCTYTPKNLGDSKHEFMECDCFEEFRDGLNHACGEDSDCINR-------- 77
+ KK + V YTP + + M C C + ++ C SDC NR
Sbjct: 522 QLKKDSSSNHVYNYTPCDHPGHPCD-MNCSCIQT-QNFCEKFCNCSSDCQNRFPGCRCKA 579
Query: 78 ----------ATLIECVNGLCKHSCGTD--------CQNQRFQKKAYADISVFKTERKGF 119
+ EC LC+ +CG D C+N Q+ + + + ++ G+
Sbjct: 580 QCNTKQCPCYLAVRECDPDLCQ-ACGADQFKLTKITCKNVCVQRGLHKHLLMAPSDIAGW 638
Query: 120 GVRANSDIEPHNFIYEYIGEVIQEEEFRNRMVKYDQMGFKHFYFMMLQTGQFIDATLKGC 179
G+ + + FI EY GE+I ++E R YD+ + + L +DAT KG
Sbjct: 639 GIFLKEGAQKNEFISEYCGEIISQDEADRRGKVYDK--YMCSFLFNLNNDFVVDATRKGN 696
Query: 180 IARFCNHSCNPNAYVNKWVVNGKLKMGIFANRHISKGEEVTFDYNVDRYGANAQ 233
RF NHS NPN Y +V G ++GIFA R I GEE+ FDY RYG Q
Sbjct: 697 KIRFANHSINPNCYAKVMMVTGDHRIGIFAKRAIQPGEELFFDY---RYGPTEQ 747
>Hs13375930 [BK] KOG1082 Histone H3 (Lys9) methyltransferase SUV39H1/Clr4
required for transcriptional silencing
Length = 350
Score = 92.8 bits (229), Expect = 2e-18
Identities = 55/156 (35%), Positives = 87/156 (55%), Gaps = 9/156 (5%)
Query: 80 LIECVNGLCKHSCGTDCQNQRFQKKAYADISVFKTER-KGFGVRANSDIEPHNFIYEYIG 138
+ EC N C+ CG DC N+ QK + +F+T +G+GV+ I+ +F+ EY+G
Sbjct: 166 IYEC-NSRCQ--CGPDCPNRIVQKGTQYSLCIFRTSNGRGWGVKTLVKIKRMSFVMEYVG 222
Query: 139 EVIQEEEFRNRMVKYDQMGFKHFYFMMLQTGQF-IDATLKGCIARFCNHSCNPNAYV-NK 196
EVI EE R YD G + + + ++ +F +DA G ++ F NHSC+PN V N
Sbjct: 223 EVITSEEAERRGQFYDNKGITYLFDLDYESDEFTVDAARYGNVSHFVNHSCDPNLQVFNV 282
Query: 197 WVVNGKLKM---GIFANRHISKGEEVTFDYNVDRYG 229
++ N ++ +F+ R I+ GEE+TFDY + G
Sbjct: 283 FIDNLDTRLPRIALFSTRTINAGEELTFDYQMKGSG 318
>CE27781 [K] KOG1081 Transcription factor NSD1 and related SET domain
proteins
Length = 898
Score = 89.4 bits (220), Expect = 2e-17
Identities = 71/222 (31%), Positives = 105/222 (46%), Gaps = 19/222 (8%)
Query: 88 CKHSCGTD--CQNQRFQKKAYAD-ISVFKTERKGFGVRANSDIEPHNFIYEYIGEVIQEE 144
C SC C N++ ++ I + T KG+GV A IE +I EY+GE+I +
Sbjct: 515 CPPSCSKKGVCHNRQVSMGIVSEKIKLAATLCKGYGVFAKGQIEKDEYICEYVGEIIDKA 574
Query: 145 EFRNRM--VKYDQMGFKHFYFMMLQTGQFIDATLKGCIARFCNHSCNPNA--YVNKWVVN 200
E + R+ V + + Y M L G +DA G I+R+ NHSC+PNA +V K V
Sbjct: 575 EKKRRLDSVSISRDFQANHYMMELHKGLTVDAARYGNISRYINHSCDPNAASFVTKVFVK 634
Query: 201 GKLKMG--------IFANRHISKGEEVTFDYNVDRYGANAQPCYCEEPNCIGFLGGKTQT 252
K K G I A R I G+E+TF YN++ N C C NC+G + GK +
Sbjct: 635 -KTKEGSLYDTRSYIRAIRTIDDGDEITFSYNMNN-EENLPDCECGAENCMGTM-GKAKR 691
Query: 253 DAASLLPQSFADALGIRPSMEKKWINMMKAKGEKIAKSDTTT 294
+ + S A S +KK + K ++ K+ T +
Sbjct: 692 EKPEVADSS-EKAAKKNKSSKKKSVKNQNRKSQEAGKNGTAS 732
>Hs21361095 [K] KOG1079 Transcriptional repressor EZH1
Length = 751
Score = 88.2 bits (217), Expect = 4e-17
Identities = 59/192 (30%), Positives = 88/192 (45%), Gaps = 14/192 (7%)
Query: 50 EFMEC--DCFEEFRDGLNHACGEDSDCINRATLIECVNGLCKHSCGT---------DCQN 98
+F +C +C F A C + EC LC +CG C+N
Sbjct: 550 KFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCL-TCGAADHWDSKNVSCKN 608
Query: 99 QRFQKKAYADISVFKTERKGFGVRANSDIEPHNFIYEYIGEVIQEEEFRNRMVKYDQMGF 158
Q+ + + + ++ G+G+ ++ + FI EY GE+I ++E R YD+ +
Sbjct: 609 CSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDK--Y 666
Query: 159 KHFYFMMLQTGQFIDATLKGCIARFCNHSCNPNAYVNKWVVNGKLKMGIFANRHISKGEE 218
+ L +DAT KG RF NHS NPN Y +VNG ++GIFA R I GEE
Sbjct: 667 MCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEE 726
Query: 219 VTFDYNVDRYGA 230
+ FDY + A
Sbjct: 727 LFFDYRYSQADA 738
>YHR119w [BK] KOG1080 Histone H3 (Lys4) methyltransferase complex subunit SET1
and related methyltransferases
Length = 1080
Score = 87.8 bits (216), Expect = 5e-17
Identities = 49/130 (37%), Positives = 68/130 (51%), Gaps = 2/130 (1%)
Query: 119 FGVRANSDIEPHNFIYEYIGEVIQEEEFRNRMVKYDQMGFKHFYFMMLQTGQFIDATLKG 178
+G+ A I I EY+GE I++ R +Y + G Y + IDAT KG
Sbjct: 950 WGLYALDSIAAKEMIIEYVGERIRQPVAEMREKRYLKNGIGSSYLFRVDENTVIDATKKG 1009
Query: 179 CIARFCNHSCNPNAYVNKWVVNGKLKMGIFANRHISKGEEVTFDYNVDRYGANAQ--PCY 236
IARF NH C+PN V G+ ++ I+A R I+ EE+T+DY +R + + PC
Sbjct: 1010 GIARFINHCCDPNCTAKIIKVGGRRRIVIYALRDIAASEELTYDYKFEREKDDEERLPCL 1069
Query: 237 CEEPNCIGFL 246
C PNC GFL
Sbjct: 1070 CGAPNCKGFL 1079
>CE27736 [BK] KOG1080 Histone H3 (Lys4) methyltransferase complex subunit SET1
and related methyltransferases
Length = 1510
Score = 87.4 bits (215), Expect = 7e-17
Identities = 49/147 (33%), Positives = 71/147 (47%), Gaps = 4/147 (2%)
Query: 100 RFQKKAYADISVFKTERKGFGVRANSDIEPHNFIYEYIGEVIQEEEFRNRMVKYDQMGFK 159
+F+KK I ++ G+G+ A I P I EYIG+ I+ R Y++ G
Sbjct: 1367 KFRKKM---IKFARSRIHGWGLYAMESIAPDEMIVEYIGQTIRSLVAEEREKAYERRGIG 1423
Query: 160 HFYFMMLQTGQFIDATLKGCIARFCNHSCNPNAYVNKWVVNGKLKMGIFANRHISKGEEV 219
Y + IDAT +G ARF NHSC PN Y + G+ ++ I++ I KGEE+
Sbjct: 1424 SSYLFRIDLHHVIDATKRGNFARFINHSCQPNCYAKVLTIEGEKRIVIYSRTIIKKGEEI 1483
Query: 220 TFDYNVDRYGANAQPCYCEEPNCIGFL 246
T+DY + C C C G+L
Sbjct: 1484 TYDYKFP-IEDDKIDCLCGAKTCRGYL 1509
>CE27735 [BK] KOG1080 Histone H3 (Lys4) methyltransferase complex subunit SET1
and related methyltransferases
Length = 1507
Score = 87.4 bits (215), Expect = 7e-17
Identities = 49/147 (33%), Positives = 71/147 (47%), Gaps = 4/147 (2%)
Query: 100 RFQKKAYADISVFKTERKGFGVRANSDIEPHNFIYEYIGEVIQEEEFRNRMVKYDQMGFK 159
+F+KK I ++ G+G+ A I P I EYIG+ I+ R Y++ G
Sbjct: 1364 KFRKKM---IKFARSRIHGWGLYAMESIAPDEMIVEYIGQTIRSLVAEEREKAYERRGIG 1420
Query: 160 HFYFMMLQTGQFIDATLKGCIARFCNHSCNPNAYVNKWVVNGKLKMGIFANRHISKGEEV 219
Y + IDAT +G ARF NHSC PN Y + G+ ++ I++ I KGEE+
Sbjct: 1421 SSYLFRIDLHHVIDATKRGNFARFINHSCQPNCYAKVLTIEGEKRIVIYSRTIIKKGEEI 1480
Query: 220 TFDYNVDRYGANAQPCYCEEPNCIGFL 246
T+DY + C C C G+L
Sbjct: 1481 TYDYKFP-IEDDKIDCLCGAKTCRGYL 1506
>CE01158 [BK] KOG1080 Histone H3 (Lys4) methyltransferase complex subunit
SET1 and related methyltransferases
Length = 739
Score = 87.4 bits (215), Expect = 7e-17
Identities = 49/147 (33%), Positives = 71/147 (47%), Gaps = 4/147 (2%)
Query: 100 RFQKKAYADISVFKTERKGFGVRANSDIEPHNFIYEYIGEVIQEEEFRNRMVKYDQMGFK 159
+F+KK I ++ G+G+ A I P I EYIG+ I+ R Y++ G
Sbjct: 596 KFRKKM---IKFARSRIHGWGLYAMESIAPDEMIVEYIGQTIRSLVAEEREKAYERRGIG 652
Query: 160 HFYFMMLQTGQFIDATLKGCIARFCNHSCNPNAYVNKWVVNGKLKMGIFANRHISKGEEV 219
Y + IDAT +G ARF NHSC PN Y + G+ ++ I++ I KGEE+
Sbjct: 653 SSYLFRIDLHHVIDATKRGNFARFINHSCQPNCYAKVLTIEGEKRIVIYSRTIIKKGEEI 712
Query: 220 TFDYNVDRYGANAQPCYCEEPNCIGFL 246
T+DY + C C C G+L
Sbjct: 713 TYDYKFP-IEDDKIDCLCGAKTCRGYL 738
>Hs4505197 [R] KOG4443 Putative transcription factor HALR/MLL3 involved in
embryonic development
Length = 5262
Score = 85.9 bits (211), Expect = 2e-16
Identities = 48/147 (32%), Positives = 76/147 (51%), Gaps = 2/147 (1%)
Query: 97 QNQRFQKKAYADISVFKTERKGFGVRANSDIEPHNFIYEYIGEVIQEEEFRNRMVKYDQM 156
Q +R + + ++ + ++ +G G+ A D+E H + EYIG +I+ E R Y++
Sbjct: 5112 QYRRLRTEWKNNVYLARSRIQGLGLYAAKDLEKHTMVIEYIGTIIRNEVANRREKIYEEQ 5171
Query: 157 GFKHFYFMMLQTGQFIDATLKGCIARFCNHSCNPNAYVNKWVVNGKLKMGIFANRHISKG 216
+ Y + IDATL G AR+ NHSC PN + + K+ I ++R I KG
Sbjct: 5172 N-RGIYMFRINNEHVIDATLTGGPARYINHSCAPNCVAEVVTFDKEDKIIIISSRRIPKG 5230
Query: 217 EEVTFDYNVD-RYGANAQPCYCEEPNC 242
EE+T+DY D + PC+C NC
Sbjct: 5231 EELTYDYQFDFEDDQHEIPCHCGAWNC 5257
>Hs19923202 [K] KOG1079 Transcriptional repressor EZH1
Length = 747
Score = 85.9 bits (211), Expect = 2e-16
Identities = 59/192 (30%), Positives = 85/192 (43%), Gaps = 14/192 (7%)
Query: 50 EFMEC--DCFEEFRDGLNHACGEDSDCINRATLIECVNGLCKHSCGTD---------CQN 98
+F +C DC F C + EC LC +CG C+N
Sbjct: 546 KFCQCNPDCQNRFPGCRCKTQCNTKQCPCYLAVRECDPDLCL-TCGASEHWDCKVVSCKN 604
Query: 99 QRFQKKAYADISVFKTERKGFGVRANSDIEPHNFIYEYIGEVIQEEEFRNRMVKYDQMGF 158
Q+ + + ++ G+G ++ + FI EY GE+I ++E R YD+ +
Sbjct: 605 CSIQRGLKKHLLLAPSDVAGWGTFIKESVQKNEFISEYCGELISQDEADRRGKVYDK--Y 662
Query: 159 KHFYFMMLQTGQFIDATLKGCIARFCNHSCNPNAYVNKWVVNGKLKMGIFANRHISKGEE 218
+ L +DAT KG RF NHS NPN Y +VNG ++GIFA R I GEE
Sbjct: 663 MSSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVVMVNGDHRIGIFAKRAIQAGEE 722
Query: 219 VTFDYNVDRYGA 230
+ FDY + A
Sbjct: 723 LFFDYRYSQADA 734
>HsM4758324 [K] KOG1079 Transcriptional repressor EZH1
Length = 746
Score = 85.5 bits (210), Expect = 3e-16
Identities = 58/192 (30%), Positives = 87/192 (45%), Gaps = 14/192 (7%)
Query: 50 EFMEC--DCFEEFRDGLNHACGEDSDCINRATLIECVNGLCKHSCGT---------DCQN 98
+F +C +C F A C + EC LC +CG C+N
Sbjct: 545 KFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCL-TCGAADHWDSKNVSCKN 603
Query: 99 QRFQKKAYADISVFKTERKGFGVRANSDIEPHNFIYEYIGEVIQEEEFRNRMVKYDQMGF 158
Q+ + + + ++ G+G+ ++ + FI EY GE+I ++E R YD+ +
Sbjct: 604 CSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDK--Y 661
Query: 159 KHFYFMMLQTGQFIDATLKGCIARFCNHSCNPNAYVNKWVVNGKLKMGIFANRHISKGEE 218
+ L +DAT KG RF NHS NPN Y +VNG ++GIFA R I GEE
Sbjct: 662 MCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEE 721
Query: 219 VTFDYNVDRYGA 230
+ DY + A
Sbjct: 722 LFVDYRYSQADA 733
>Hs22045532 [BK] KOG1082 Histone H3 (Lys9) methyltransferase SUV39H1/Clr4
required for transcriptional silencing
Length = 365
Score = 85.1 bits (209), Expect = 3e-16
Identities = 67/222 (30%), Positives = 99/222 (44%), Gaps = 39/222 (17%)
Query: 54 CDCFEEFRDGLNHACGEDSDCIN--------RATLIECVNGLCKHSCGTDCQNQRFQKKA 105
C C R G N+ +D+ C+ + EC N LC+ C C+N+ QK
Sbjct: 87 CSCL---RHGENY---DDNSCLRDIGSGGKYAEPVFEC-NVLCR--CSDHCRNRVVQKGL 137
Query: 106 YADISVFKTERKGFGVRANSDIEPHNFIYEYIGEVIQEEEFRNRM---VKYDQ---MGFK 159
VFKT +KG+G+R I F+ EY GEV+ E + R+ K D + +
Sbjct: 138 QFHFQVFKTHKKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRIHLQTKSDSNYIIAIR 197
Query: 160 HFYFMMLQTGQFIDATLKGCIARFCNHSCNPNAYVNKWVVNGKL-KMGIFANRHISKGEE 218
+ F+D T G I RF NHSC PN + ++ + K+ +FA + I EE
Sbjct: 198 EHVYNGQVMETFVDPTYIGNIGRFLNHSCEPNLLMIPVRIDSMVPKLALFAAKDIVPEEE 257
Query: 219 VTFDYNVDRY--------------GANAQPCYCEEPNCIGFL 246
+++DY+ RY G +PCYC +C FL
Sbjct: 258 LSYDYS-GRYLNLTVSEDKERLDHGKLRKPCYCGAKSCTAFL 298
>CE27623 [BK] KOG1082 Histone H3 (Lys9) methyltransferase SUV39H1/Clr4
required for transcriptional silencing
Length = 244
Score = 85.1 bits (209), Expect = 3e-16
Identities = 62/183 (33%), Positives = 86/183 (46%), Gaps = 12/183 (6%)
Query: 75 INRAT--LIECVNGLCKHSCGTDCQNQRFQKKAYADISVFKT--ERKGFGVRANSDIEPH 130
IN+++ LIEC + T C+N+ Q + +F T KGFGVRA I
Sbjct: 55 INKSSELLIECSDQCACILLPTSCRNRVVQCGPQKKLEIFSTCEMAKGFGVRAGEQIAAG 114
Query: 131 NFIYEYIGEVIQEEEFRNRMVKYD-----QMGFKHFYFMMLQTGQFIDATLKGCIARFCN 185
F+ EY GE I E+E R ++ + K F F F+D L+G I RF N
Sbjct: 115 EFVCEYAGECIGEQEVERRCREFRGDDNYTLTLKEF-FGGKPVKTFVDPRLRGNIGRFLN 173
Query: 186 HSCNPNAYVNKWVVNGKL-KMGIFANRHISKGEEVTFDYNVDRY-GANAQPCYCEEPNCI 243
HSC PN + + + GIFA R I +GEE+ +DY G N + C C+ C
Sbjct: 174 HSCEPNCEIILARLGRMIPAAGIFAKRDIVRGEELCYDYGHSAIEGENRKLCLCKSEKCR 233
Query: 244 GFL 246
+L
Sbjct: 234 KYL 236
>SPBC428.08c_2 [BK] KOG1082 Histone H3 (Lys9) methyltransferase SUV39H1/Clr4
required for transcriptional silencing
Length = 364
Score = 85.1 bits (209), Expect = 3e-16
Identities = 63/218 (28%), Positives = 95/218 (42%), Gaps = 26/218 (11%)
Query: 54 CDCFEEFRDGLNHACGEDSD--CINRATLIECVNGLCKHSCGTDCQNQRFQKKAYADISV 111
C+C ++ + + A A + EC N C SC +C N+ Q+ + +
Sbjct: 150 CECLDDLDEPTHFAYDAQGRVRADTGAVIYEC-NSFC--SCSMECPNRVVQRGRTLPLEI 206
Query: 112 FKTERKGFGVRANSDIEPHNFIYEYIGEVIQEEEFRNRMVKYDQMGFKHFYFMML---QT 168
FKT+ KG+GVR+ FI Y+GEVI E R YD G + + + + +
Sbjct: 207 FKTKEKGWGVRSLRFAPAGTFITCYLGEVITSAEAAKRDKNYDDDGITYLFDLDMFDDAS 266
Query: 169 GQFIDATLKGCIARFCNHSCNPNAYVNKWVVNGKLK----MGIFANRHISKGEEVTFDY- 223
+DA G ++RF NHSC+PN + V N + + FA + I EE+TFDY
Sbjct: 267 EYTVDAQNYGDVSRFFNHSCSPNIAIYSAVRNHGFRTIYDLAFFAIKDIQPLEELTFDYA 326
Query: 224 -------------NVDRYGANAQPCYCEEPNCIGFLGG 248
+R + C C NC G+L G
Sbjct: 327 GAKDFSPVQSQKSQQNRISKLRRQCKCGSANCRGWLFG 364
>Hs5730039_1 [BK] KOG1082 Histone H3 (Lys9) methyltransferase SUV39H1/Clr4
required for transcriptional silencing
Length = 328
Score = 85.1 bits (209), Expect = 3e-16
Identities = 67/222 (30%), Positives = 99/222 (44%), Gaps = 39/222 (17%)
Query: 54 CDCFEEFRDGLNHACGEDSDCIN--------RATLIECVNGLCKHSCGTDCQNQRFQKKA 105
C C R G N+ +D+ C+ + EC N LC+ C C+N+ QK
Sbjct: 74 CSCL---RHGENY---DDNSCLRDIGSGGKYAEPVFEC-NVLCR--CSDHCRNRVVQKGL 124
Query: 106 YADISVFKTERKGFGVRANSDIEPHNFIYEYIGEVIQEEEFRNRM---VKYDQ---MGFK 159
VFKT +KG+G+R I F+ EY GEV+ E + R+ K D + +
Sbjct: 125 QFHFQVFKTHKKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRIHLQTKSDSNYIIAIR 184
Query: 160 HFYFMMLQTGQFIDATLKGCIARFCNHSCNPNAYVNKWVVNGKL-KMGIFANRHISKGEE 218
+ F+D T G I RF NHSC PN + ++ + K+ +FA + I EE
Sbjct: 185 EHVYNGQVMETFVDPTYIGNIGRFLNHSCEPNLLMIPVRIDSMVPKLALFAAKDIVPEEE 244
Query: 219 VTFDYNVDRY--------------GANAQPCYCEEPNCIGFL 246
+++DY+ RY G +PCYC +C FL
Sbjct: 245 LSYDYS-GRYLNLTVSASKERLDHGKLRKPCYCGAKSCTAFL 285
>Hs5174569 [K] KOG1084 Transcription factor TCF20
Length = 3969
Score = 84.0 bits (206), Expect = 7e-16
Identities = 48/149 (32%), Positives = 74/149 (49%), Gaps = 2/149 (1%)
Query: 99 QRFQKKAYADISVFKTERKGFGVRANSDIEPHNFIYEYIGEVIQEEEFRNRMVKYDQMGF 158
+ +K + + V+++ G G+ +I+ + EY G VI+ + R YD G
Sbjct: 3821 RHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGI 3880
Query: 159 KHFYFMMLQTGQFIDATLKGCIARFCNHSCNPNAYVNKWVVNGKLKMGIFANRHISKGEE 218
+ F + + +DAT+ G ARF NHSC PN Y ++G+ + IFA R I +GEE
Sbjct: 3881 GCYMFR-IDDSEVVDATMHGNRARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEE 3939
Query: 219 VTFDYNVD-RYGANAQPCYCEEPNCIGFL 246
+T+DY +N PC C C FL
Sbjct: 3940 LTYDYKFPIEDASNKLPCNCGAKKCRKFL 3968
>Hs22059579 [BK] KOG1080 Histone H3 (Lys4) methyltransferase complex subunit
SET1 and related methyltransferases
Length = 772
Score = 83.2 bits (204), Expect = 1e-15
Identities = 53/159 (33%), Positives = 76/159 (47%), Gaps = 7/159 (4%)
Query: 91 SCGTDCQ--NQ-RFQKKAYADISVFKTERKGFGVRANSDIEPHNFIYEYIGEVIQEEEFR 147
SC +D NQ +F+KK + K+ +G+ A I + EY+G+ I++
Sbjct: 617 SCDSDLLKFNQLKFRKKK---LKFCKSHIHDWGLFAMEPIAADEMVIEYVGQNIRQVIAD 673
Query: 148 NRMVKYDQMGFKHFYFMMLQTGQFIDATLKGCIARFCNHSCNPNAYVNKWVVNGKLKMGI 207
R +Y+ G Y + IDAT G ARF NHSCNPN Y V + K+ I
Sbjct: 674 MREKRYEDEGIGSSYMFRVDHDTIIDATKCGNFARFINHSCNPNCYAKVITVESQKKIVI 733
Query: 208 FANRHISKGEEVTFDYNVDRYGANAQPCYCEEPNCIGFL 246
++ +HI+ EE+T+DY PC C NC G L
Sbjct: 734 YSKQHINVNEEITYDYKFPIEDVKI-PCLCGSENCRGTL 771
>Hs10864041 [R] KOG4443 Putative transcription factor HALR/MLL3 involved in
embryonic development
Length = 4025
Score = 82.4 bits (202), Expect = 2e-15
Identities = 48/147 (32%), Positives = 74/147 (49%), Gaps = 2/147 (1%)
Query: 97 QNQRFQKKAYADISVFKTERKGFGVRANSDIEPHNFIYEYIGEVIQEEEFRNRMVKYDQM 156
Q ++ + + +++ + ++ +G G+ A DIE H + EYIG +I+ E NR K +
Sbjct: 3875 QYRKMKTEWKSNVYLARSRIQGLGLYAARDIEKHTMVIEYIGTIIRNE-VANRKEKLYES 3933
Query: 157 GFKHFYFMMLQTGQFIDATLKGCIARFCNHSCNPNAYVNKWVVNGKLKMGIFANRHISKG 216
+ Y + IDATL G AR+ NHSC PN K+ I ++R I KG
Sbjct: 3934 QNRGVYMFRMDNDHVIDATLTGGPARYINHSCAPNCVAEVVTFERGHKIIISSSRRIQKG 3993
Query: 217 EEVTFDYNVD-RYGANAQPCYCEEPNC 242
EE+ +DY D + PC+C NC
Sbjct: 3994 EELCYDYKFDFEDDQHKIPCHCGAVNC 4020
>ECU09g1750 [K] KOG1079 Transcriptional repressor EZH1
Length = 537
Score = 81.3 bits (199), Expect = 5e-15
Identities = 59/179 (32%), Positives = 83/179 (45%), Gaps = 12/179 (6%)
Query: 52 MECDCFE--EFRDGLNHACGEDSDCINRATLIECVNG-LCKHSCGTDCQNQRFQKKAYAD 108
M C C E F G +S C R EC LCK C N+ Q A
Sbjct: 350 MSCLCTECRNFFMGCRCPAKCNSKCACRQASRECTQVCLCKQ-----CGNKDLQMGKAAP 404
Query: 109 ISVFKTERKGFGVRANSDIEPHNFIYEYIGEVIQEEEFRNRMVKYDQMGFKHFYFMMLQT 168
V + +G+G+ A + F+ EY+GE+I EE R YD G + + + +
Sbjct: 405 TFVAPSRVEGYGLFAKEKMSKGRFVIEYVGEIISNEEAERRGTFYDLRGCSYLFDLYSRE 464
Query: 169 GQ---FIDATLKGCIARFCNHS-CNPNAYVNKWVVNGKLKMGIFANRHISKGEEVTFDY 223
G+ ID+ G +RF NHS N N Y +VNG ++G +A+R I +GEE+ FDY
Sbjct: 465 GKALYVIDSRFIGNRSRFINHSQRNSNLYAFVLIVNGVRRIGFYASRDICEGEELLFDY 523
>CE16398 [R] KOG4443 Putative transcription factor HALR/MLL3 involved in
embryonic development
Length = 2561
Score = 80.1 bits (196), Expect = 1e-14
Identities = 49/152 (32%), Positives = 77/152 (50%), Gaps = 5/152 (3%)
Query: 99 QRFQKKAYADISVFKTERKGFGVRANSDIEPHNFIYEYIGEVIQEEEFRNRMVKYDQMGF 158
Q+ +++ + + ++ G G+ A DI +FI EY GE+I+ E R ++Y
Sbjct: 2410 QKMRREWKDRVYLARSRIAGLGLYAKVDISMGDFIIEYKGEIIRSEVCEVREIRYVAQN- 2468
Query: 159 KHFYFMMLQTGQFIDATLKGCIARFCNHSCNPNAYVNKWVVNG---KLKMGIFANRHISK 215
+ Y + IDAT+ G AR+ NHSC+PN + K+ I ANR IS
Sbjct: 2469 RGVYMFRIDEEWVIDATMAGGPARYINHSCDPNCSTQILDAGSGAREKKIIITANRPISA 2528
Query: 216 GEEVTFDYNVDRYGANAQ-PCYCEEPNCIGFL 246
EE+T+DY + G + PC C PNC+ ++
Sbjct: 2529 NEELTYDYQFELEGTTDKIPCLCGAPNCVKWM 2560
>7299982 [BK] KOG1082 Histone H3 (Lys9) methyltransferase SUV39H1/Clr4
required for transcriptional silencing
Length = 635
Score = 79.3 bits (194), Expect = 2e-14
Identities = 54/155 (34%), Positives = 77/155 (48%), Gaps = 12/155 (7%)
Query: 78 ATLIECVNGLCKHSCGTDCQNQRFQKKAYADISVFKTER-KGFGVRANSDIEPHNFIYEY 136
+ + EC N C SC + C N+ Q + +FKT G+GVRA + + F+ EY
Sbjct: 451 SAIYEC-NSRC--SCDSSCSNRLVQHGRQVPLVLFKTANGSGWGVRAATALRKGEFVCEY 507
Query: 137 IGEVIQEEEFRNRMVKYDQMGFKHFYFMMLQTGQ----FIDATLKGCIARFCNHSCNPN- 191
IGE+I +E R YD G + + + T Q IDA G I+ F NHSC+PN
Sbjct: 508 IGEIITSDEANERGKAYDDNGRTYLFDLDYNTAQDSEYTIDAANYGNISHFINHSCDPNL 567
Query: 192 AYVNKWVVNGKLKMG---IFANRHISKGEEVTFDY 223
A W+ + + + F R I GEE++FDY
Sbjct: 568 AVFPCWIEHLNVALPHLVFFTLRPIKAGEELSFDY 602
>7289568 [BK] KOG1080 Histone H3 (Lys4) methyltransferase complex subunit
SET1 and related methyltransferases
Length = 177
Score = 79.0 bits (193), Expect = 2e-14
Identities = 46/147 (31%), Positives = 69/147 (46%), Gaps = 4/147 (2%)
Query: 100 RFQKKAYADISVFKTERKGFGVRANSDIEPHNFIYEYIGEVIQEEEFRNRMVKYDQMGFK 159
+F+KK + K+ +G+ A I + EY+G++I+ R KY+ +G
Sbjct: 34 KFRKK---QLKFAKSAIHDWGLFAMEPIAADEMVIEYVGQMIRPVVADLRETKYEAIGIG 90
Query: 160 HFYFMMLQTGQFIDATLKGCIARFCNHSCNPNAYVNKWVVNGKLKMGIFANRHISKGEEV 219
Y + IDAT G +ARF NHSCNPN Y + + K+ I++ + I EE+
Sbjct: 91 SSYLFRIDMETIIDATKCGNLARFINHSCNPNCYAKVITIESEKKIVIYSKQPIGINEEI 150
Query: 220 TFDYNVDRYGANAQPCYCEEPNCIGFL 246
T+DY PC C C G L
Sbjct: 151 TYDYKFPLEDEKI-PCLCGAQGCRGTL 176
>At2g31630 [BK] KOG1080 Histone H3 (Lys4) methyltransferase complex subunit
SET1 and related methyltransferases
Length = 186
Score = 78.6 bits (192), Expect = 3e-14
Identities = 52/151 (34%), Positives = 74/151 (48%), Gaps = 6/151 (3%)
Query: 97 QNQRFQKKAYADISVF-KTERKGFGVRANSDIEPHNFIYEYIGEVIQEE--EFRNRMVKY 153
+ R+ ++ Y F K+ GFG+ A + + EY GE+++ + R +++ Y
Sbjct: 12 EKYRYMRETYRKRLAFGKSGIHGFGIFAKLPHRAGDMMIEYTGELVRPSIADKREQLI-Y 70
Query: 154 DQMGFKHFYFMMLQTGQFIDATLKGCIARFCNHSCNPNAYVNKWVVNGKLKMGIFANRHI 213
+ MG + F + + IDAT G IA NHSC PN Y VNG + IFA RHI
Sbjct: 71 NSMGAGTYMFR-IDDERVIDATRTGSIAHLINHSCVPNCYSRVITVNGDEHIIIFAKRHI 129
Query: 214 SKGEEVTFDYNVDRYGANAQPCYCEEPNCIG 244
K EE+T+DY G C C P C G
Sbjct: 130 PKWEELTYDYRFFSIGERLS-CSCGFPGCRG 159
>Hs7662046 [K] KOG1084 Transcription factor TCF20
Length = 2715
Score = 78.2 bits (191), Expect = 4e-14
Identities = 49/149 (32%), Positives = 71/149 (46%), Gaps = 2/149 (1%)
Query: 99 QRFQKKAYADISVFKTERKGFGVRANSDIEPHNFIYEYIGEVIQEEEFRNRMVKYDQMGF 158
+ +K + + V+++ G G+ +I+ + EY G VI+ R YD G
Sbjct: 2567 RHLKKTSKEAVGVYRSAIHGRGLFCKRNIDAGEMVIEYSGIVIRSVLTDKREKFYDGKGI 2626
Query: 159 KHFYFMMLQTGQFIDATLKGCIARFCNHSCNPNAYVNKWVVNGKLKMGIFANRHISKGEE 218
+ F M +DAT+ G ARF NHSC PN + V G+ + IFA R I +GEE
Sbjct: 2627 GCYMFRM-DDFDVVDATMHGNAARFINHSCEPNCFSRVIHVEGQKHIVIFALRRILRGEE 2685
Query: 219 VTFDYNVD-RYGANAQPCYCEEPNCIGFL 246
+T+DY +N PC C C FL
Sbjct: 2686 LTYDYKFPIEDASNKLPCNCGAKRCRRFL 2714
>At4g02020 [K] KOG1079 Transcriptional repressor EZH1
Length = 898
Score = 77.8 bits (190), Expect = 5e-14
Identities = 57/207 (27%), Positives = 86/207 (41%), Gaps = 25/207 (12%)
Query: 54 CDCFEEFRDGLNHACGEDSDCINR-----ATLIECVNGLCKH---SCGT----------- 94
C C + ++ S C +R A EC +C++ SCG
Sbjct: 676 CGCSKSCKNRFRGCHCAKSQCRSRQCPCFAAGRECDPDVCRNCWVSCGDGSLGEAPRRGE 735
Query: 95 -DCQNQRFQKKAYADISVFKTERKGFGVRANSDIEPHNFIYEYIGEVIQEEEFRNRMVKY 153
C N R + I + K++ G+G + + + ++ EY GE+I E R Y
Sbjct: 736 GQCGNMRLLLRQQQRILLGKSDVAGWGAFLKNSVSKNEYLGEYTGELISHHEADKRGKIY 795
Query: 154 DQMGFKHFYFMMLQTGQFIDATLKGCIARFCNHSCNPNAYVNKWVVNGKLKMGIFANRHI 213
D+ + L +DA KG +F NHS PN Y V G ++GIFAN I
Sbjct: 796 DRANSS--FLFDLNDQYVLDAQRKGDKLKFANHSAKPNCYAKVMFVAGDHRVGIFANERI 853
Query: 214 SKGEEVTFDYNVDRYGANAQPCYCEEP 240
EE+ +DY RYG + P + +P
Sbjct: 854 EASEELFYDY---RYGPDQAPVWARKP 877
>Hs21314722 [BK] KOG1082 Histone H3 (Lys9) methyltransferase SUV39H1/Clr4
required for transcriptional silencing
Length = 1267
Score = 77.4 bits (189), Expect = 7e-14
Identities = 63/228 (27%), Positives = 100/228 (43%), Gaps = 31/228 (13%)
Query: 37 CTYTPKNLGDSKHEFMECDCFEEFRDG------LNHACGEDSDC-----INRAT---LIE 82
C +P N+ + C C ++ L+ C D D N A + E
Sbjct: 1014 CVTSPMNIDRNITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFE 1073
Query: 83 CVNGLCKHSCGTDCQNQRFQKKAYADISVFKTERKGFGVRANSDIEPHNFIYEYIGEVIQ 142
C N C SC +C+N+ Q A + +++T G+GVR+ DI P F+ EY+GE+I
Sbjct: 1074 C-NHAC--SCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELIS 1130
Query: 143 EEEFRNRMVKYDQMGFKHFYFMMLQTGQF--IDATLKGCIARFCNHSCNPNAY-VNKWVV 199
+ E R + + + + G+ IDA G ++RF NH C PN V ++
Sbjct: 1131 DSEADVREED------SYLFDLDNKDGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMA 1184
Query: 200 NGKL---KMGIFANRHISKGEEVTFDYNVDRYGANAQ--PCYCEEPNC 242
+ L ++ F+ R I GE++ FDY + + C C P C
Sbjct: 1185 HQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCRCGSPKC 1232
>At1g05830_2 [BK] KOG1080 Histone H3 (Lys4) methyltransferase complex subunit
SET1 and related methyltransferases
Length = 582
Score = 77.0 bits (188), Expect = 9e-14
Identities = 52/150 (34%), Positives = 73/150 (48%), Gaps = 11/150 (7%)
Query: 101 FQKKAYADISVF-KTERKGFGVRANSDIEPHNFIYEYIGEVIQEE--EFRNRMVKYDQMG 157
F K+ Y F K+ GFG+ A + + EY GE+++ + R ++ Y+ M
Sbjct: 313 FMKETYRKRLAFGKSGIHGFGIFAKLPHRAGDMVIEYTGELVRPPIADKREHLI-YNSMV 371
Query: 158 FKHFYFMMLQTGQFIDATLKGCIARFCNHSCNPNAYVNKWVVNGKLKMGIFANRHISKGE 217
Y + + IDAT G IA NHSC PN Y VNG + IFA R ++K E
Sbjct: 372 GAGTYMFRIDNERVIDATRTGSIAHLINHSCEPNCYSRVISVNGDEHIIIFAKRDVAKWE 431
Query: 218 EVTFDY---NVDRYGANAQPCYCEEPNCIG 244
E+T+DY ++D A CYC P C G
Sbjct: 432 ELTYDYRFFSIDERLA----CYCGFPRCRG 457
>CE13601 [K] KOG1083 Putative transcription factor ASH1/LIN-59
Length = 1312
Score = 76.6 bits (187), Expect = 1e-13
Identities = 48/158 (30%), Positives = 75/158 (47%), Gaps = 12/158 (7%)
Query: 67 ACGEDSDCINRATLIECVNGLCKHSCGTD-CQNQRFQKKAYAD-ISVFKTERKGFGVRAN 124
AC D DC+NRA ++C + C C N+RF K+ + + V R ++
Sbjct: 601 ACTSDMDCLNRALRVQCSS-----DCSVPYCSNRRFWKEDCGNKLCVSNGPRSKRVLKTK 655
Query: 125 SDIEPHNFIYEYIGEVIQEEEFRNRMVKYDQMGFKHFYFMMLQTGQFIDATLKGCIARFC 184
F+ EY GEVI E+ + + + + + + F+DAT + IARF
Sbjct: 656 IARRAGEFLCEYAGEVITREQAQEKFAQD-----RDPRIIAIAAHLFVDATKRSNIARFI 710
Query: 185 NHSCNPNAYVNKWVVNGKLKMGIFANRHISKGEEVTFD 222
HSC PN+ + W VNG + G+FA ++ E+T D
Sbjct: 711 KHSCKPNSRLEVWSVNGFYRAGVFALSDLNPNAEITVD 748
>At2g23380 [K] KOG1079 Transcriptional repressor EZH1
Length = 902
Score = 75.9 bits (185), Expect = 2e-13
Identities = 46/151 (30%), Positives = 75/151 (49%), Gaps = 7/151 (4%)
Query: 95 DCQNQRFQKKAYADISVFKTERKGFGVRANSDIEPHNFIYEYIGEVIQEEEFRNRMVKYD 154
+C+N + K + + ++ G+G + + H ++ EY GE+I +E R YD
Sbjct: 740 ECRNMKLLLKQQQRVLLGISDVSGWGAFLKNSVSKHEYLGEYTGELISHKEADKRGKIYD 799
Query: 155 QMGFKHFYFMMLQTGQFI-DATLKGCIARFCNHSCNPNAYVNKWVVNGKLKMGIFANRHI 213
+ ++ F+ QF+ DA KG +F NHS PN Y +V G ++GIFA I
Sbjct: 800 R---ENCSFLFNLNDQFVLDAYRKGDKLKFANHSPEPNCYAKVIMVAGDHRVGIFAKERI 856
Query: 214 SKGEEVTFDYNVDRYGANAQPCYCEEPNCIG 244
GEE+ +DY RY + P + ++P G
Sbjct: 857 LAGEELFYDY---RYEPDRAPAWAKKPEAPG 884
>At2g22740_2 [BK] KOG1082 Histone H3 (Lys9) methyltransferase SUV39H1/Clr4
required for transcriptional silencing
Length = 294
Score = 75.1 bits (183), Expect = 3e-13
Identities = 67/247 (27%), Positives = 101/247 (40%), Gaps = 55/247 (22%)
Query: 30 TYAELDVCTYTPKNLGDSKHEFMECDCFEEFRDGLNHACGEDSDCINRATLIECVNGLCK 89
T AE VC KN G+ + F DG + T+ EC LCK
Sbjct: 64 TEAEARVCACVEKNGGEIPYNF----------DGAIVGA--------KPTIYEC-GPLCK 104
Query: 90 HSCGTDCQNQRFQKKAYADISVFKTERKGFGVRANSDIEPHNFIYEYIGEVIQEEEFRNR 149
C + C + Q + +FKT+ +G+GVR I +FI EY+GE++++ E R
Sbjct: 105 --CPSSCYLRVTQHGIKLPLEIFKTKSRGWGVRCLKSIPIGSFICEYVGELLEDSEAERR 162
Query: 150 M----------VKYDQMGFKHFYFMMLQT-------------GQFIDATLKGCIARFCNH 186
+ +YD + +ML T G IDA KG + RF NH
Sbjct: 163 IGNDEYLFDIGNRYDNSLAQGMSELMLGTQAGRSMAEGDESSGFTIDAASKGNVGRFINH 222
Query: 187 SCNPNAYVNKWVVNGK----LKMGIFANRHISKGEEVTFDYNV-------DRYGANAQPC 235
SC+PN Y + + + + FA +I +E+ +DYN + +PC
Sbjct: 223 SCSPNLYAQNVLYDHEDSRIPHVMFFAQDNIPPLQELCYDYNYALDQVRDSKGNIKQKPC 282
Query: 236 YCEEPNC 242
+C C
Sbjct: 283 FCGAAVC 289
>CE28067 [K] KOG1079 Transcriptional repressor EZH1
Length = 773
Score = 72.0 bits (175), Expect = 3e-12
Identities = 64/209 (30%), Positives = 91/209 (42%), Gaps = 36/209 (17%)
Query: 33 ELDVCTYTPKNLGDSKHEFMECDCFEEFRDGLNHACGEDSDCINRATLIECVNGLCK--- 89
E VC+Y K + +C + F G N A G+ C +A N C
Sbjct: 548 ENGVCSYMCK---------CDINCSQRF-PGCNCAAGQ---CYTKACQCYRANWECNPMT 594
Query: 90 -HSCGTD--------CQN----QRFQKKAYADISVFKTERKGFGVRANSDIEPHNFIYEY 136
+ C D C+N + QK+ Y S G G+ E FI EY
Sbjct: 595 CNMCKCDAIDSNIIKCRNFGMTRMIQKRTYCGPSKIA----GNGLFLLEPAEKDEFITEY 650
Query: 137 IGEVIQEEEFRNRMVKYDQMGFKHFYFMMLQTGQFIDATLKGCIARFCNH-SCNPNAYVN 195
GE I ++E R YD+ ++ Y ++TG ID+ G +ARF NH S NP Y
Sbjct: 651 TGERISDDEAERRGAIYDR--YQCSYIFNIETGGAIDSYKIGNLARFANHDSKNPTCYAR 708
Query: 196 KWVVNGKLKMGIFANRHISKGEEVTFDYN 224
VV G+ ++G +A R + EE+TFDY+
Sbjct: 709 TMVVAGEHRIGFYAKRRLEISEELTFDYS 737
>Hs18426879 [BK] KOG1082 Histone H3 (Lys9) methyltransferase SUV39H1/Clr4
required for transcriptional silencing
Length = 1176
Score = 71.6 bits (174), Expect = 4e-12
Identities = 64/230 (27%), Positives = 103/230 (43%), Gaps = 35/230 (15%)
Query: 37 CTYTPKNLGDSKHEFMECDCFEEFRDGLNHACGEDS---------------DCINRATLI 81
C + N+ + C C ++ N CG+ S + I +
Sbjct: 923 CETSTMNIDRNITHLQHCTCVDDCSSS-NCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIF 981
Query: 82 ECVNGLCKHSCGTDCQNQRFQKKAYADISVFKTERKGFGVRANSDIEPHNFIYEYIGEVI 141
EC N C SC +C+N+ Q + +++T + G+GVRA I FI EY+GE+I
Sbjct: 982 EC-NQAC--SCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELI 1038
Query: 142 QEEEFRNRMVKYDQMGFKHFYFMMLQTGQF--IDATLKGCIARFCNHSCNPNAY-VNKWV 198
+ E V+ D + + + + G+ IDA G I+RF NH C+PN V ++
Sbjct: 1039 SDAE---ADVREDD---SYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFM 1092
Query: 199 VNGKL---KMGIFANRHISKGEEVTFDYNVDRY---GANAQPCYCEEPNC 242
++ L ++ F++R I GEE+ FDY DR+ + C C C
Sbjct: 1093 LHQDLRFPRIAFFSSRDIRTGEELGFDYG-DRFWDIKSKYFTCQCGSEKC 1141
>Hs18375637 [BK] KOG1082 Histone H3 (Lys9) methyltransferase SUV39H1/Clr4
required for transcriptional silencing
Length = 1210
Score = 71.6 bits (174), Expect = 4e-12
Identities = 64/230 (27%), Positives = 103/230 (43%), Gaps = 35/230 (15%)
Query: 37 CTYTPKNLGDSKHEFMECDCFEEFRDGLNHACGEDS---------------DCINRATLI 81
C + N+ + C C ++ N CG+ S + I +
Sbjct: 957 CETSTMNIDRNITHLQHCTCVDDCSSS-NCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIF 1015
Query: 82 ECVNGLCKHSCGTDCQNQRFQKKAYADISVFKTERKGFGVRANSDIEPHNFIYEYIGEVI 141
EC N C SC +C+N+ Q + +++T + G+GVRA I FI EY+GE+I
Sbjct: 1016 EC-NQAC--SCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELI 1072
Query: 142 QEEEFRNRMVKYDQMGFKHFYFMMLQTGQF--IDATLKGCIARFCNHSCNPNAY-VNKWV 198
+ E V+ D + + + + G+ IDA G I+RF NH C+PN V ++
Sbjct: 1073 SDAE---ADVREDD---SYLFDLDNKDGEVYCIDARYYGNISRFINHLCDPNIIPVRVFM 1126
Query: 199 VNGKL---KMGIFANRHISKGEEVTFDYNVDRY---GANAQPCYCEEPNC 242
++ L ++ F++R I GEE+ FDY DR+ + C C C
Sbjct: 1127 LHQDLRFPRIAFFSSRDIRTGEELGFDYG-DRFWDIKSKYFTCQCGSEKC 1175
>At3g03750 [BK] KOG1082 Histone H3 (Lys9) methyltransferase SUV39H1/Clr4
required for transcriptional silencing
Length = 354
Score = 71.6 bits (174), Expect = 4e-12
Identities = 59/184 (32%), Positives = 87/184 (47%), Gaps = 22/184 (11%)
Query: 82 ECVNGLCKHSCGTDCQNQRFQKKAYADISVFKTERKGFGVRANSDIEPHNFIYEYIGEVI 141
EC +G CG+DC N+ QK + + + E+KG+ + A+ I+ FI EY GE++
Sbjct: 169 ECGSGC---GCGSDCSNRVTQKGVSVSLKIVRDEKKGWCLYADQLIKQGQFICEYAGELL 225
Query: 142 QEEEFRNRMVKYDQMGFKHFYFMM-------LQTGQF-----IDATLKGCIARFCNHSCN 189
+E R R YD++ + L +GQ IDAT G +ARF NHSC+
Sbjct: 226 TTDEARRRQNIYDKLRSTQSFASALLVVREHLPSGQACLRINIDATRIGNVARFINHSCD 285
Query: 190 -PNAYVNKWVVNGKL--KMGIFANRHISKGEEVTFDY-NVDRYGANAQP---CYCEEPNC 242
N +G L ++ FA + I EE++F Y +V G N C C C
Sbjct: 286 GGNLSTVLLRSSGALLPRLCFFAAKDIIAEEELSFSYGDVSVAGENRDDKLNCSCGSSCC 345
Query: 243 IGFL 246
+G L
Sbjct: 346 LGTL 349
>At5g53430 [BK] KOG1080 Histone H3 (Lys4) methyltransferase complex subunit SET1
and related methyltransferases
Length = 1040
Score = 68.6 bits (166), Expect = 3e-11
Identities = 43/132 (32%), Positives = 66/132 (49%), Gaps = 4/132 (3%)
Query: 118 GFGVRANSDIEPHNFIYEYIGEVIQEEEFRNRMVKYDQMGFKHFYFMMLQTGQFIDATLK 177
G+G+ A +I+ + EY GE ++ R +Y + G K Y + +DAT K
Sbjct: 909 GWGLFARRNIQEGEMVLEYRGEQVRGIIADLREARYRREG-KDCYLFKISEEVVVDATEK 967
Query: 178 GCIARFCNHSCNPNAYVNKWVV-NGKLKMGIFANRHISKGEEVTFDY--NVDRYGANAQP 234
G IAR NHSC PN Y V + + ++ + A ++ EE+T+DY + D P
Sbjct: 968 GNIARLINHSCMPNCYARIMSVGDDESRIVLIAKTTVASCEELTYDYLFDPDEPDEFKVP 1027
Query: 235 CYCEEPNCIGFL 246
C C+ PNC F+
Sbjct: 1028 CLCKSPNCRKFM 1039
>At2g35160_2 [BK] KOG1082 Histone H3 (Lys9) methyltransferase SUV39H1/Clr4
required for transcriptional silencing
Length = 254
Score = 68.6 bits (166), Expect = 3e-11
Identities = 52/171 (30%), Positives = 86/171 (49%), Gaps = 19/171 (11%)
Query: 88 CKHSCGTDCQNQRFQKKAYADISVFKTERKGFGVRANSDIEPHNFIYEYIGEVIQEEEFR 147
CK C C + Q + +FKTE +G+GVR+ I +FI EY GE++++++
Sbjct: 90 CK--CPPSCNMRVSQHGIKIKLEIFKTESRGWGVRSLESIPIGSFICEYAGELLEDKQAE 147
Query: 148 NRMVKYDQMGFKHFYFMMLQTGQF-IDATLKGCIARFCNHSCNPNAYVNKWVVNGK---- 202
+ K + + + + + F I+A KG I RF NHSC+PN Y + + +
Sbjct: 148 SLTGKDE-----YLFDLGDEDDPFTINAAQKGNIGRFINHSCSPNLYAQDVLYDHEEIRI 202
Query: 203 LKMGIFANRHISKGEEVTFDYN--VDR-YGANA----QPCYCEEPNCIGFL 246
+ FA +I +E+++DYN +D+ Y +N + CYC C G L
Sbjct: 203 PHIMFFALDNIPPLQELSYDYNYKIDQVYDSNGNIKKKFCYCGSAECSGRL 253
>CE09911 [BK] KOG1082 Histone H3 (Lys9) methyltransferase SUV39H1/Clr4
required for transcriptional silencing
Length = 401
Score = 66.2 bits (160), Expect = 2e-10
Identities = 56/159 (35%), Positives = 77/159 (48%), Gaps = 13/159 (8%)
Query: 70 EDSDCINRATLIECVNGLCKHSCGTDCQNQRFQKKAYADISVFKTERK-GFGVRANSDIE 128
E+ + + T+ EC N C +C C N+ QK A + +F + G+GVRA+ DI
Sbjct: 231 ENMELLMWDTVREC-NEYC--NCALWCGNRVAQKGAMYPVEIFARDPWCGWGVRASVDIA 287
Query: 129 PHNFIYEYIGEVIQEEEFRNRMVKYDQMGFKHFYFMMLQTGQFIDATLKGCIARFCNHSC 188
FI EY GE+I +EE M ++D F + IDA G RF NHSC
Sbjct: 288 FGTFIGEYAGELIDDEE---AMDRHDSTFL--FETKVGSETLTIDAKYSGNYTRFINHSC 342
Query: 189 NPNAYVN--KWVVN--GKLKMGIFANRHISKGEEVTFDY 223
PN V W + + M F ++ I KGEE+T DY
Sbjct: 343 APNVKVANISWDYDKIQLIHMCFFTDKAIRKGEELTIDY 381
>CE08853 [BK] KOG1082 Histone H3 (Lys9) methyltransferase SUV39H1/Clr4
required for transcriptional silencing
Length = 737
Score = 65.5 bits (158), Expect = 3e-10
Identities = 50/182 (27%), Positives = 78/182 (42%), Gaps = 29/182 (15%)
Query: 88 CKHSCGTDCQNQRFQKKAYADISVFKTERK-GFGVRANSDIEPHNFIYEYIGEVIQEEEF 146
CK +C T+ QKK Y+ I +++ + + GFG+R+ I I EY GE++ E
Sbjct: 467 CKGAC-TNNATYLIQKKLYS-IEIYRADPQIGFGIRSTLFIPAGTPIIEYCGELVDGERL 524
Query: 147 RNRMVKY-----DQMGFKHFYFMMLQTGQ-----------------FIDATLKGCIARFC 184
+ + Y D G KH Y ++ + + +DA ++G + RF
Sbjct: 525 HSSLENYSYQLTDCEGDKHLYNLLREKYKNNPEYYDVLDELSKHHFHLDAKMQGSVGRFA 584
Query: 185 NHSCNPNAYVNKWVVNG----KLKMGIFANRHISKGEEVTFDYNVDRYGANAQPCYCEEP 240
NHSC PN + G ++M F + I GE +T DY + Q C C
Sbjct: 585 NHSCTPNMEPLRLFKEGFTPANMRMIFFTLKDIFPGEPLTLDYGSEYKVFRRQRCLCRTF 644
Query: 241 NC 242
C
Sbjct: 645 AC 646
>7290020 [BK] KOG1082 Histone H3 (Lys9) methyltransferase SUV39H1/Clr4
required for transcriptional silencing
Length = 1624
Score = 65.5 bits (158), Expect = 3e-10
Identities = 45/157 (28%), Positives = 67/157 (42%), Gaps = 17/157 (10%)
Query: 88 CKHSCGTD---CQNQRFQKKAYADISVFKTE--RKGFGVRANSDIEPHNFIYEYIGEVIQ 142
C CG + C+N+ Q + + + E KG+GVRA +++ F+ Y GE++
Sbjct: 1428 CNDVCGCNQLSCKNRVVQNGTRTPLQIVECEDQAKGWGVRALANVPKGTFVGSYTGEILT 1487
Query: 143 EEEFRNRMVKYDQMGFKHFYFMMLQTGQFIDATLKGCIARFCNHSCNPNAYVNKWVVNGK 202
E R Y+ L G IDA G + RF NHSC PN + +
Sbjct: 1488 AMEADRRT--------DDSYYFDLDNGHCIDANYYGNVTRFFNHSCEPNVLPVRVFYEHQ 1539
Query: 203 ----LKMGIFANRHISKGEEVTFDYNVDRYGANAQPC 235
K+ F+ R I GEE+ FDY + + C
Sbjct: 1540 DYRFPKIAFFSCRDIDAGEEICFDYGEKFWRVEHRSC 1576
>At1g17770_2 [BK] KOG1082 Histone H3 (Lys9) methyltransferase SUV39H1/Clr4
required for transcriptional silencing
Length = 288
Score = 62.4 bits (150), Expect = 2e-09
Identities = 59/199 (29%), Positives = 85/199 (42%), Gaps = 35/199 (17%)
Query: 54 CDCFEEFRDGLNHACGEDSDCINRATLIECVNGLCKHSCGTDCQNQRFQKKAYADISVFK 113
C C + D L + ++ + R LI G C C C + Q + VFK
Sbjct: 66 CTCVQRNGDLLPY---HNNILVCRKPLIYECGGSCP--CPDHCPTRLVQTGLKLHLEVFK 120
Query: 114 TERKGFGVRANSDIEPHNFIYEYIG------EVIQEEEFRNRMVKYDQMGFKHFY----- 162
T G+G+R+ I FI E+ G EV +++++ K Q F+ Y
Sbjct: 121 TRNCGWGLRSWDPIRAGTFICEFAGLRKTKEEVEEDDDYLFDTSKIYQR-FRWNYEPELL 179
Query: 163 ----------FMMLQTGQFIDATLKGCIARFCNHSCNPNA------YVNKWVVNGKLKMG 206
F+ L T I A KG + RF NHSC+PN Y N+ V L +G
Sbjct: 180 LEDSWEQVSEFINLPTQVLISAKEKGNVGRFMNHSCSPNVFWQPIEYENRGDV--YLLIG 237
Query: 207 IFANRHISKGEEVTFDYNV 225
+FA +HI E+T+DY V
Sbjct: 238 LFAMKHIPPMTELTYDYGV 256
>7299371 [BK] KOG1082 Histone H3 (Lys9) methyltransferase SUV39H1/Clr4
required for transcriptional silencing
Length = 223
Score = 56.6 bits (135), Expect = 1e-07
Identities = 34/123 (27%), Positives = 60/123 (48%), Gaps = 10/123 (8%)
Query: 80 LIECVNGLCKHSCGTDCQNQRFQKKAYADISVFKTERKGF-GVRANSDIEPHNFIYEYIG 138
+IEC N +CK C C N+ + +F + G G+R + I +I EY G
Sbjct: 86 VIEC-NDMCK-CCRNTCSNRLVYSGPRKHLEIFDSPVYGSKGLRTTAKITKGGYICEYAG 143
Query: 139 EVIQEEEFRNRMVKYDQMGFKHFYFMM-------LQTGQFIDATLKGCIARFCNHSCNPN 191
E++ E R+R+ +++G ++ ++ Q +D + +G I R+ NHSC PN
Sbjct: 144 ELLTVPEARSRLHDNEKLGLMNYILVLNEYTSDKKQQVTIVDPSRRGNIGRYLNHSCEPN 203
Query: 192 AYV 194
++
Sbjct: 204 CHI 206
>At3g04380 [BK] KOG1082 Histone H3 (Lys9) methyltransferase SUV39H1/Clr4
required for transcriptional silencing
Length = 424
Score = 55.8 bits (133), Expect = 2e-07
Identities = 38/116 (32%), Positives = 55/116 (46%), Gaps = 17/116 (14%)
Query: 88 CKHSCGTD--CQNQRFQKKAYADISVFKT-ERKGFGVRANSDIEPHNFIYEYIGEVIQEE 144
C CG D C N+ Q+ + V+ T E KG+G+R D+ FI EYIGE++
Sbjct: 265 CWRKCGCDMQCGNRVVQRGIRCQLQVYFTQEGKGWGLRTLQDLPKGTFICEYIGEILTNT 324
Query: 145 EFRNRMVKYDQMGFKHFYFMML------------QTGQFIDATLKGCIARFCNHSC 188
E +R V+ +H Y + L + +DAT+ G +ARF NH C
Sbjct: 325 ELYDRNVR--SSSERHTYPVTLDADWGSEKDLKDEEALCLDATICGNVARFINHRC 378
>Hs20543055 [R] KOG1844 PHD Zn-finger proteins
Length = 609
Score = 54.3 bits (129), Expect = 6e-07
Identities = 38/127 (29%), Positives = 57/127 (43%), Gaps = 6/127 (4%)
Query: 121 VRANSDIEPHNFIYEYIGEVIQEEEFRNRMVKYDQ-MGFKHFYFMMLQTGQFIDATLKGC 179
+++ D+ P I EY G+ + E+F + + F FY +DA G
Sbjct: 343 LKSAKDLPPDALIIEYRGKFMLREQFEANGYFFKRPYPFVLFYSKFHGLEMCVDARTFGN 402
Query: 180 IARFCNHSCNPNAYVNKWVVNGKLKMGIFANRHISKGEEVT----FDYNVDRYGANAQPC 235
ARF SC PNA V + +G + + I++ I KG E+T FDY +Y + C
Sbjct: 403 EARFIRRSCTPNAEVRHEIQDGTIHLYIYSIHSIPKGTEITIAFDFDYGNCKYKVDC-AC 461
Query: 236 YCEEPNC 242
E P C
Sbjct: 462 LKENPEC 468
>7299871 [R] KOG1085 Predicted methyltransferase (contains a SET domain)
Length = 689
Score = 51.6 bits (122), Expect = 4e-06
Identities = 34/111 (30%), Positives = 53/111 (47%), Gaps = 4/111 (3%)
Query: 117 KGFGVRANSDIEPHNFIYEYIGEVIQEEEFRNRMVKY---DQMGFKHFYFMMLQTGQFID 173
KG GV A+ + + F+ EY+G++I E R +Y + G +YF ID
Sbjct: 563 KGRGVVADRPFKRNEFVVEYVGDLISIGEAAEREKRYALDENAGCYMYYFKHKSQQYCID 622
Query: 174 ATLK-GCIARFCNHSCNPNAYVNKWVVNGKLKMGIFANRHISKGEEVTFDY 223
AT+ G + R NHS N ++ + + + A I GEE+T+DY
Sbjct: 623 ATVDTGKLGRLINHSRAGNLMTKVVLIKQRPHLVLLAKDDIEPGEELTYDY 673
>CE25069 [B] KOG1141 Predicted histone methyl transferase
Length = 1327
Score = 50.8 bits (120), Expect = 7e-06
Identities = 27/81 (33%), Positives = 43/81 (52%), Gaps = 6/81 (7%)
Query: 172 IDATLKGCIARFCNHSCNPNAYVNKWVVN-GKLKM---GIFANRHISKGEEVTFDYNV-- 225
IDA +G + RF NHSC+PN +V + + L++ F +++ G+E+T+DY
Sbjct: 1244 IDAKQRGNLGRFLNHSCDPNVHVQHVMYDTHDLRLPWVAFFTRKYVKAGDELTWDYQYTQ 1303
Query: 226 DRYGANAQPCYCEEPNCIGFL 246
D+ C+C NC G L
Sbjct: 1304 DQTATTQLTCHCGAENCTGRL 1324
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.317 0.133 0.389
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 41,483,980
Number of Sequences: 60738
Number of extensions: 1853044
Number of successful extensions: 8657
Number of sequences better than 1.0e-05: 68
Number of HSP's better than 0.0 without gapping: 39
Number of HSP's successfully gapped in prelim test: 29
Number of HSP's that attempted gapping in prelim test: 8463
Number of HSP's gapped (non-prelim): 104
length of query: 702
length of database: 30,389,216
effective HSP length: 113
effective length of query: 589
effective length of database: 23,525,822
effective search space: 13856709158
effective search space used: 13856709158
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)