ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactI1889 good BK KOG2684 Chromatin structure and dynamics Sirtuin 5 and related class III sirtuins (SIR2 family)
r_klactI1889 good BK KOG2684 Transcription Sirtuin 5 and related class III sirtuins (SIR2 family)
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactI1889 646013 644637 -459
(459 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YOR025w [BK] KOG2684 Sirtuin 5 and related class III sirtuins (S... 455 e-128
SPAC1783.04c [BK] KOG2684 Sirtuin 5 and related class III sirtui... 176 9e-44
YDR191w [BK] KOG2684 Sirtuin 5 and related class III sirtuins (S... 157 3e-38
ECU03g0460 [BK] KOG2684 Sirtuin 5 and related class III sirtuins... 147 2e-35
7298007 [BK] KOG2684 Sirtuin 5 and related class III sirtuins (S... 135 1e-31
YOL068c [BK] KOG2684 Sirtuin 5 and related class III sirtuins (S... 124 3e-28
Hs7657575 [BK] KOG2684 Sirtuin 5 and related class III sirtuins ... 124 4e-28
YDL042c [BK] KOG2684 Sirtuin 5 and related class III sirtuins (S... 122 9e-28
CE06302 [BK] KOG2684 Sirtuin 5 and related class III sirtuins (S... 114 4e-25
Hs6912660 [BK] KOG2682 NAD-dependent histone deacetylases and cl... 102 2e-21
SPCC132.02 [BK] KOG2682 NAD-dependent histone deacetylases and c... 100 8e-21
Hs13775602 [BK] KOG2682 NAD-dependent histone deacetylases and c... 98 2e-20
Hs13775600 [BK] KOG2682 NAD-dependent histone deacetylases and c... 98 2e-20
SPBC16D10.07c [BK] KOG2684 Sirtuin 5 and related class III sirtu... 96 1e-19
YPL015c [BK] KOG2682 NAD-dependent histone deacetylases and clas... 67 4e-11
Hs6912662 [BK] KOG2683 Sirtuin 4 and related class II sirtuins (... 64 6e-10
7299319 [BK] KOG1905 Class IV sirtuins (SIR2 family) 62 2e-09
Hs6912664 [BK] KOG2684 Sirtuin 5 and related class III sirtuins ... 55 3e-07
Hs13787215 [BK] KOG2684 Sirtuin 5 and related class III sirtuins... 55 3e-07
At5g55760 [BK] KOG1905 Class IV sirtuins (SIR2 family) 54 4e-07
>YOR025w [BK] KOG2684 Sirtuin 5 and related class III sirtuins (SIR2 family)
Length = 447
Score = 455 bits (1170), Expect = e-128
Identities = 221/356 (62%), Positives = 280/356 (78%), Gaps = 7/356 (1%)
Query: 40 LGSMIQTERVKHLSLSEYRETNENSELISQINRVIHRSRKCAVLTGAGISCNAGIPDFRS 99
L S +QTE++ H+ + + E++ ++ + + RSR+ A LTGAGISCNAGIPDFRS
Sbjct: 20 LPSSLQTEKLAHII-----GLDADDEVLRRVTKQLSRSRRIACLTGAGISCNAGIPDFRS 74
Query: 100 FEGLYRMVKEQYPDV-NIRSGQDMFDISLFREEEKISVFASFMENLYSHTIQAKPTKTHE 158
+GLY +VK+ +I+SG++MFDISLFR++ KIS+FA FME LYS+ AKPTKTH+
Sbjct: 75 SDGLYDLVKKDCSQYWSIKSGREMFDISLFRDDFKISIFAKFMERLYSNVQLAKPTKTHK 134
Query: 159 FIAHLKNRGKLLRCYTQNIDGLEEMLGLQMSKSRDADQSFSIQWKNLDVVQLHGDLTTLS 218
FIAHLK+R KLLRCYTQNIDGLEE +GL +S + SFS WKNLDVVQLHGDL TLS
Sbjct: 135 FIAHLKDRNKLLRCYTQNIDGLEESIGLTLSNRKLPLTSFSSHWKNLDVVQLHGDLKTLS 194
Query: 219 CTQCFKVFSWSRHWKRCLKNGELPVCPKCLEKNNRRSIEGKRCLGHS-GMLRPNIVLYGE 277
CT+CF+ F WSR+W RCL+ GELP+CP C N+R EGKR LG + G+LRPNIVLYGE
Sbjct: 195 CTKCFQTFPWSRYWSRCLRRGELPLCPDCEALINKRLNEGKRTLGSNVGILRPNIVLYGE 254
Query: 278 NHPNADFITQGLNMDINRGKPDLFLIMGTSLKVDGVKRLVKTISKQVHDRGGLVILINKT 337
NHP+ + ITQGLN+DI +G PD +IMGTSLKVDGVK+LVK +SK++HDRGGL+IL+NKT
Sbjct: 255 NHPSCEIITQGLNLDIIKGNPDFLIIMGTSLKVDGVKQLVKKLSKKIHDRGGLIILVNKT 314
Query: 338 SIGDCNWHGIIDYQIESDCDEWVTELKKHMSDFFLSQQQLEKVRQMKREASELRKR 393
IG+ +WHGIIDYQI SDCD WVT L+ + DFF +Q Q++K+RQ+KREAS+LRK+
Sbjct: 315 PIGESSWHGIIDYQIHSDCDNWVTFLESQIPDFFKTQDQIKKLRQLKREASDLRKQ 370
>SPAC1783.04c [BK] KOG2684 Sirtuin 5 and related class III sirtuins (SIR2 family)
Length = 415
Score = 176 bits (445), Expect = 9e-44
Identities = 111/278 (39%), Positives = 167/278 (59%), Gaps = 19/278 (6%)
Query: 61 NENSELISQINRVIHRSRKCAVLTGAGISCNAGIPDFRSFEGLYRMVKEQYPDVNIRSGQ 120
NEN +L S + I ++++ V+TGAGISC+AGIPDFRS EGL+ ++ +Y +N SG+
Sbjct: 42 NENVDL-SPLVSAIRKAKRIVVVTGAGISCDAGIPDFRSSEGLFSSLRAEYK-LNC-SGK 98
Query: 121 DMFDISLFREEEKISVFASFMENLYSHTIQAKPTKTHEFIAHLKNRGKLLRCYTQNIDGL 180
++FD S++R+ + +++F + + L+ + A+PT H F++ L KLLR YTQNID L
Sbjct: 99 ELFDGSVYRDLKSVNIFHAMIRKLHMLSNNARPTDFHLFLSQLAQESKLLRLYTQNIDFL 158
Query: 181 EEML-GLQMSKSRDADQSFSIQWKNLDVVQLHGDLTTLSCTQCFKVFSWSRHWKRCL--K 237
E L GLQ S W + LHG L +SCT+C S+ + + + +
Sbjct: 159 ETRLEGLQTC----IPLPQSAPWPT--TIPLHGTLEVVSCTRC----SFLKKFNPDIFDR 208
Query: 238 NGELPVCPKCLEKNNRRSIEGKRCLGHSGMLRPNIVLYGENHPNADFITQGLNMDINRGK 297
NG + VCP C +N R I GKR + G LRP IVLY E HP+++ I + D+ + +
Sbjct: 209 NG-VTVCPDCKTENEVRRIAGKRSV-IEGCLRPRIVLYNEIHPDSESIGSVCSQDL-KSR 265
Query: 298 PDLFLIMGTSLKVDGVKRLVKTISKQVHDRGGLVILIN 335
PD ++ GTS K+ GVKR++K +S VH + G VI +N
Sbjct: 266 PDCLIVAGTSCKIPGVKRIIKEMSNCVHKQKGNVIWLN 303
>YDR191w [BK] KOG2684 Sirtuin 5 and related class III sirtuins (SIR2 family)
Length = 370
Score = 157 bits (397), Expect = 3e-38
Identities = 99/291 (34%), Positives = 152/291 (52%), Gaps = 25/291 (8%)
Query: 51 HLSLSEYRETNENSELISQINRVIHRSRKCAVLTGAGISCNAGIPDFRSFEGLYRMVKEQ 110
HLS S+ + ++ IS ++ S++ V++GAGIS AGIPDFRS EG++ V
Sbjct: 69 HLSKSQRHHMDRDAGFISY---ALNYSKRMVVVSGAGISVAAGIPDFRSSEGIFSTV--- 122
Query: 111 YPDVNIRSGQDMFDISLFREEEKISV-FASFMENLYSHTIQAKPTKTHEFIAHLKNRGKL 169
N SG+D+FD + +E +S+ F M +L+ + +PTK HE + G+L
Sbjct: 123 ----NGGSGKDLFDYNRVYGDESMSLKFNQLMVSLFRLSKNCQPTKFHEMLNEFARDGRL 178
Query: 170 LRCYTQNIDGLEEMLGLQMSKSRDADQSFSIQWKNLDVVQLHGDLTTLSCTQCFKVFSWS 229
LR YTQNIDGL+ L + + VQLHG + + C +C + +
Sbjct: 179 LRLYTQNIDGLDTQL-------PHLSTNVPLAKPIPSTVQLHGSIKHMECNKCLNIKPFD 231
Query: 230 RHWKRC-----LKNGELPVCPKCLEKNNRRSIEGKRCLGHSGMLRPNIVLYGENHPNADF 284
+C + +P CP+C E R + G R G G LRP ++LY E HP DF
Sbjct: 232 PELFKCDDKFDSRTEIIPSCPQCEEYETVRKMAGLRSTG-VGKLRPRVILYNEVHPEGDF 290
Query: 285 ITQGLNMDINRGKPDLFLIMGTSLKVDGVKRLVKTISKQVHDRGGLVILIN 335
I + N D+ + + D +I+GTSLK+ GVK + + + +VH G+V+ +N
Sbjct: 291 IGEIANNDLKK-RIDCLIIVGTSLKIPGVKNICRQFAAKVHANRGIVLYLN 340
>ECU03g0460 [BK] KOG2684 Sirtuin 5 and related class III sirtuins (SIR2 family)
Length = 425
Score = 147 bits (372), Expect = 2e-35
Identities = 96/288 (33%), Positives = 154/288 (53%), Gaps = 24/288 (8%)
Query: 78 RKCAVLTGAGISCNAGIPDFRSFEGLYRMVKEQYPDVNIRSGQDMFDISLFREEEKISVF 137
R+ V+TGAGIS ++GIPDFRS GL+ +K+ D+ + SG D+F SL +E +
Sbjct: 86 RRVVVITGAGISVSSGIPDFRSKSGLFNDIKK---DLGV-SGNDLFTYSLSMSKELRKGY 141
Query: 138 ASFMENLYSHTIQAKPTKTHEFIAHLKNRGKLLRCYTQNIDGLEEMLGLQMSKSRDADQS 197
++ L + +A+P+ THEF++ + + R YTQNIDGLEE GL +K R
Sbjct: 142 LRYISKLKNMVDKAQPSATHEFLSLYSDISRRFRIYTQNIDGLEEKAGLAATKDR----- 196
Query: 198 FSIQWKNLDVVQLHGDLTTLSCTQCFKVFSWSRHWKRCLKNGELPVCPKCLEKNNRRSIE 257
+ +V LHG++ +L C C + + GE VC C+ +N +R +
Sbjct: 197 ------STRLVYLHGNMKSLGCLYCGYKIEFGDAERDAYGRGEEIVCAGCVRRNEKRGRD 250
Query: 258 GKRCLGHSGMLRPNIVLYGENHPNADFITQGLNMDINRGKPDLFLIMGTSLKVDGVKRLV 317
++ G+ I+ Y ++HP++ FI++ D DLF++MGTSLKV GV+RLV
Sbjct: 251 VRK--RPVGVFHTTIIHYNQSHPDSSFISKMAEHD---NTCDLFIVMGTSLKVFGVRRLV 305
Query: 318 KTISKQVHDRGGLVIL-INKTSIGDCNWHGIIDYQIESDCDEWVTELK 364
K + RG +++ +++ S + + D+ DCDE+ LK
Sbjct: 306 KYFCRLNSTRGRRILVNLDRPS---KEFGELFDFFWNGDCDEFCRVLK 350
>7298007 [BK] KOG2684 Sirtuin 5 and related class III sirtuins (SIR2 family)
Length = 823
Score = 135 bits (341), Expect = 1e-31
Identities = 97/306 (31%), Positives = 154/306 (49%), Gaps = 49/306 (16%)
Query: 73 VIHRSRKCAVLTGAGISCNAGIPDFRSFEGLYRMVKEQYPDVNIRSGQDMFDISLFREEE 132
++ +S+K VLTGAG+S + GIPDFRS G+Y + +PD + Q MFDI+ F+ +
Sbjct: 217 LVKKSQKIIVLTGAGVSVSCGIPDFRSTNGIYARLAHDFPD--LPDPQAMFDINYFKRDP 274
Query: 133 KISVFASFMENLYSHTIQAKPTKTHEFIAHLKNRGKLLRCYTQNIDGLEEMLGLQMSKSR 192
+ F F +Y Q P+ H FI L+ +GKLLR YTQNID LE + G+Q
Sbjct: 275 R--PFYKFAREIYPGEFQ--PSPCHRFIKMLETKGKLLRNYTQNIDTLERVAGIQR---- 326
Query: 193 DADQSFSIQWKNLDVVQLHGDLTTLSCTQC-FKVFSWSRHWKRCLKNGELPVCPKCLEKN 251
V++ HG +T SCT+C FK + + + + +PVCP+C + N
Sbjct: 327 --------------VIECHGSFSTASCTKCRFKCNADA--LRADIFAQRIPVCPQC-QPN 369
Query: 252 NRRSIEGK--------RCLGHSGMLRPNIVLYGENHPNADFITQGLNMDINRGKPDLFLI 303
+S++ R L +G+++P+IV +GE P+ + D+ DL ++
Sbjct: 370 KEQSVDASVAVTEEELRQLVENGIMKPDIVFFGEGLPDEYHTVMATDKDV----CDLLIV 425
Query: 304 MGTSLKVDGVKRLVKTISKQVHDRGGLVILINKTSIGDCNWHGIIDYQIESDCDEWVTEL 363
+G+SLKV V + +I V ILIN+ + H D ++ D D + ++
Sbjct: 426 IGSSLKVRPVAHIPSSIPATVPQ-----ILINREQL----HHLKFDVELLGDSDVIINQI 476
Query: 364 KKHMSD 369
+SD
Sbjct: 477 CHRLSD 482
>YOL068c [BK] KOG2684 Sirtuin 5 and related class III sirtuins (SIR2 family)
Length = 503
Score = 124 bits (311), Expect = 3e-28
Identities = 101/354 (28%), Positives = 158/354 (44%), Gaps = 74/354 (20%)
Query: 63 NSELISQINRVIHRSRKCAVLTGAGISCNAGIPDFRSFEGLYRMVKEQYPDVNIRSGQDM 122
N I + ++K VLTGAG+S + GIPDFRS EG Y ++ + + QD+
Sbjct: 186 NFNTIDHFTATLRNAKKILVLTGAGVSTSLGIPDFRSSEGFYSKIRH----LGLEDPQDV 241
Query: 123 FDISLFREEEKISVFASFM----ENLYSHTIQAKPTKTHEFIAHLKNRGKLLRCYTQNID 178
F++ +F ++ + + M EN+YS H FI L+++GKLLR YTQNID
Sbjct: 242 FNLDIFLQDPSVFYNIAHMVLPPENMYS--------PLHSFIKMLQDKGKLLRNYTQNID 293
Query: 179 GLEEMLGLQMSKSRDADQSFSIQWKNLDVVQLHGDLTTLSCTQCFKVFSWSRHWK----- 233
LE G+ K +VQ HG T SC C HW+
Sbjct: 294 NLESYAGIDPDK----------------LVQCHGSFATASCVTC--------HWQIPGEK 329
Query: 234 --RCLKNGELPVCPKCLEK--------NNRRSIE-----GKRCLGHSGMLRPNIVLYGEN 278
++N ELP+CP C +K N +++ L G+L+P++ +GE
Sbjct: 330 IFENIRNLELPLCPYCYQKRKQYFPMSNGNNTVQTNINFNSPILKSYGVLKPDMTFFGEA 389
Query: 279 HPNADFITQGLNMDINRGKPDLFLIMGTSLKVDGVKRLVKTISKQVHDRGGLVILINKTS 338
P+ T + DI + DL + +GTSLKV V +V + V ILIN+
Sbjct: 390 LPSRFHKT--IRKDIL--ECDLLICIGTSLKVAPVSEIVNMVPSHVPQ-----ILINR-- 438
Query: 339 IGDCNWHGIIDYQIESDCDEWVTELKKHMSDFFLSQQQLEKVRQMKREASELRK 392
D H D + CD+ V L + + ++ + ++++ +E+ K
Sbjct: 439 --DMVTHAEFDLNLLGFCDD-VASLVAKKCHWDIPHKKWQDLKKIDYNCTEIDK 489
>Hs7657575 [BK] KOG2684 Sirtuin 5 and related class III sirtuins (SIR2 family)
Length = 747
Score = 124 bits (310), Expect = 4e-28
Identities = 97/313 (30%), Positives = 148/313 (46%), Gaps = 52/313 (16%)
Query: 52 LSLSEYRETNENSELISQINRVIHRSRKCAVLTGAGISCNAGIPDFRSFEGLYRMVKEQY 111
LS R+ ++ I +++ +K VLTGAG+S + GIPDFRS +G+Y + +
Sbjct: 228 LSEPPKRKKRKDINTIEDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDF 287
Query: 112 PDVNIRSGQDMFDISLFREEEKISVFASFMENLYSHTIQAKPTKTHEFIAHLKNRGKLLR 171
PD + Q MFDI FR++ + F F + +Y Q +P+ H+FIA GKLLR
Sbjct: 288 PD--LPDPQAMFDIEYFRKDPR--PFFKFAKEIYPG--QFQPSLCHKFIALSDKEGKLLR 341
Query: 172 CYTQNIDGLEEMLGLQMSKSRDADQSFSIQWKNLDVVQLHGDLTTLSCTQC-FKVFSWSR 230
YTQNID LE++ G+Q ++Q HG T SC C +KV
Sbjct: 342 NYTQNIDTLEQVAGIQR------------------IIQCHGSFATASCLICKYKVD--CE 381
Query: 231 HWKRCLKNGELPVCPKCLEKNNRRSIEGKRCLGHSGMLRPNIVLYGENHPNADFITQGLN 290
+ + N +P CP+C +++P IV +GEN P
Sbjct: 382 AVRGDIFNQVVPRCPRCPADE------------PLAIMKPEIVFFGENLPEQFHRA---- 425
Query: 291 MDINRGKPDLFLIMGTSLKVDGVKRLVKTISKQVHDRGGLVILINKTSIGDCNWHGIIDY 350
M ++ + DL +++G+SLKV V + +I +V ILIN+ + H D
Sbjct: 426 MKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQ-----ILINREPLP----HLHFDV 476
Query: 351 QIESDCDEWVTEL 363
++ DCD + EL
Sbjct: 477 ELLGDCDVIINEL 489
>YDL042c [BK] KOG2684 Sirtuin 5 and related class III sirtuins (SIR2 family)
Length = 562
Score = 122 bits (307), Expect = 9e-28
Identities = 95/307 (30%), Positives = 140/307 (44%), Gaps = 64/307 (20%)
Query: 74 IHRSRKCAVLTGAGISCNAGIPDFRSFEGLYRMVKEQYPDVNIRSGQDMFDISLFREEEK 133
+H +RK VLTGAG+S + GIPDFRS EG Y +K + + QD+F+ ++F +
Sbjct: 251 LHTARKILVLTGAGVSTSLGIPDFRSSEGFYSKIKH----LGLDDPQDVFNYNIFMHDPS 306
Query: 134 ISVFASFM----ENLYSHTIQAKPTKTHEFIAHLKNRGKLLRCYTQNIDGLEEMLGLQMS 189
+ + M E +YS H FI L+ +GKLLR YTQNID LE G+
Sbjct: 307 VFYNIANMVLPPEKIYS--------PLHSFIKMLQMKGKLLRNYTQNIDNLESYAGISTD 358
Query: 190 KSRDADQSFSIQWKNLDVVQLHGDLTTLSCTQCFKVFSWSRHWKRCLKNGELPVCPKCLE 249
K +VQ HG T +C C R + + ++N ELP+CP C +
Sbjct: 359 K----------------LVQCHGSFATATCVTCHWNLPGERIFNK-IRNLELPLCPYCYK 401
Query: 250 K---------NNRRSIEGKR---------CLGHSGMLRPNIVLYGENHPNADFITQGLNM 291
K NN+ + + L G+L+P+I +GE PN + +
Sbjct: 402 KRREYFPEGYNNKVGVAASQGSMSERPPYILNSYGVLKPDITFFGEALPNK--FHKSIRE 459
Query: 292 DINRGKPDLFLIMGTSLKVDGVKRLVKTISKQVHDRGGLVILINKTSIGDCNWHGIIDYQ 351
DI + DL + +GTSLKV V +V + V +LIN+ + H D
Sbjct: 460 DIL--ECDLLICIGTSLKVAPVSEIVNMVPSHVPQ-----VLINRDPVK----HAEFDLS 508
Query: 352 IESDCDE 358
+ CD+
Sbjct: 509 LLGYCDD 515
>CE06302 [BK] KOG2684 Sirtuin 5 and related class III sirtuins (SIR2 family)
Length = 607
Score = 114 bits (284), Expect = 4e-25
Identities = 90/306 (29%), Positives = 145/306 (46%), Gaps = 61/306 (19%)
Query: 60 TNENSELISQINRVIHRSRKCAVLTGAGISCNAGIPDFRSFEGLYRMVKEQYPDVNIRSG 119
TN NS ++ + + VLTGAG+S + GIPDFRS +G+Y ++ ++PD +
Sbjct: 130 TNYNS--LADAVELFKTKKHILVLTGAGVSVSCGIPDFRSKDGIYARLRSEFPD--LPDP 185
Query: 120 QDMFDISLFREEEKISVFASFMENLYSHTIQAKPTKTHEFIAHLKNRGKLLRCYTQNIDG 179
MFDI FRE + F +F ++ Q P+ +H FI L+ G+LLR YTQNID
Sbjct: 186 TAMFDIRYFRENP--APFYNFAREIFPG--QFVPSVSHRFIKELETSGRLLRNYTQNIDT 241
Query: 180 LEEMLGLQMSKSRDADQSFSIQWKNLDVVQLHGDLTTLSCTQCFKVFSWSRHWKRCLKNG 239
LE G++ VV+ HG + +CT+C + + + + L
Sbjct: 242 LEHQTGIKR------------------VVECHGSFSKCTCTRCGQKYDGNEIREEVLA-- 281
Query: 240 ELPVCPKCLEKNNRRSIEGKRCLGHSGMLRPNIVLYGEN--HPNADFITQGLNMDINRGK 297
R KRC G+++PNIV +GE+ +T+ ++ K
Sbjct: 282 -------------MRVAHCKRC---EGVIKPNIVFFGEDLGREFHQHVTE------DKHK 319
Query: 298 PDLFLIMGTSLKVDGVKRLVKTISKQVHDRGGLVILINKTSIGDCNWHGIIDYQIESDCD 357
DL +++G+SLKV V + + K V ILIN+ S+ N D ++ +CD
Sbjct: 320 VDLIVVIGSSLKVRPVALIPHCVDKNVPQ-----ILINRESLPHYN----ADIELLGNCD 370
Query: 358 EWVTEL 363
+ + ++
Sbjct: 371 DIIRDI 376
>Hs6912660 [BK] KOG2682 NAD-dependent histone deacetylases and class I
sirtuins (SIR2 family)
Length = 399
Score = 102 bits (253), Expect = 2e-21
Identities = 85/277 (30%), Positives = 128/277 (45%), Gaps = 62/277 (22%)
Query: 76 RSRKC---AVLTGAGISCNAGIPDFRS-FEGLYRMVKEQ---YPDVNIRSGQDMFDISLF 128
R+R C V+ GAGIS +GIPDFRS GLY +++ YP+ +F++ F
Sbjct: 133 RARACQRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQYDLPYPEA-------IFELPFF 185
Query: 129 REEEKISVFASFMENLYSHTIQAKPTKTHEFIAHLKNRGKLLRCYTQNIDGLEEMLGLQM 188
K F + + LY KP TH F+ L ++G LLR YTQNIDGLE + G+
Sbjct: 186 FHNPK--PFFTLAKELYPGNY--KPNVTHYFLRLLHDKGLLLRLYTQNIDGLERVSGIPA 241
Query: 189 SKSRDADQSFSIQWKNLDVVQLHGDLTTLSCTQCFKVFSWSRHWKRCLKNGELPVCPKCL 248
SK +V+ HG + +CT C + F + + +P CP C
Sbjct: 242 SK----------------LVEAHGTFASATCTVCQRPFP-GEDIRADVMADRVPRCPVC- 283
Query: 249 EKNNRRSIEGKRCLGHSGMLRPNIVLYGENHPNADFITQGLNMDINRGKPDLFLIMGTSL 308
+G+++P+IV +GE P F+ ++ + DL LI+GTSL
Sbjct: 284 ----------------TGVVKPDIVFFGEPLPQR-FLLHVVDFPM----ADLLLILGTSL 322
Query: 309 KVDGVKRLVKTISKQVHDRGGLVILINKTSIGDCNWH 345
+V+ L + + V +LIN+ +G WH
Sbjct: 323 EVEPFASLTEAVRSSVPR-----LLINRDLVGPLAWH 354
>SPCC132.02 [BK] KOG2682 NAD-dependent histone deacetylases and class I
sirtuins (SIR2 family)
Length = 332
Score = 99.8 bits (247), Expect = 8e-21
Identities = 90/318 (28%), Positives = 144/318 (44%), Gaps = 60/318 (18%)
Query: 49 VKHLSLSEYRETNENSELISQINRVIHRSRKCAVLTGAGISCNAGIPDFRSFE-GLYRMV 107
VKH+ S++ E + + LI + + +K V+ GAGIS AGIPDFRS E G+Y +
Sbjct: 6 VKHVDSSKHLE--KVASLIKE-----GKVKKICVMVGAGISTAAGIPDFRSPETGIYNNL 58
Query: 108 KEQYPDVNIRSGQDMFDISLFREEEKISVFASFMENLYSHTIQAKPTKTHEFIAHLKNRG 167
+ N+ + +FD+S FR+ + F L + +PT TH FI L ++
Sbjct: 59 QR----FNLPYAEAVFDLSYFRKNPR--PFYELAHELMPE--KYRPTYTHYFIRLLHDKR 110
Query: 168 KLLRCYTQNIDGLEEMLGLQMSKSRDADQSFSIQWKNLDVVQLHGDLTTLSCTQCFKVFS 227
L +CYTQNID LE + G+ + +++ HG C +C+++ +
Sbjct: 111 LLQKCYTQNIDTLERLAGV----------------PDKALIEAHGSFQYSRCIECYEM-A 153
Query: 228 WSRHWKRCLKNGELPVCPKCLEKNNRRSIEGKRCLGHSGMLRPNIVLYGENHPNADFITQ 287
+ + + C+ ++P C C G+++P IV YGE P F
Sbjct: 154 ETEYVRACIMQKQVPKCNSC-----------------KGLIKPMIVFYGEGLPMRFF--- 193
Query: 288 GLNMDINRGKPDLFLIMGTSLKVDGVKRLVKTISKQVHDRGGLVILINKTSIGDCNWHGI 347
+M+ + D+ L++GTSL V L + + + +LIN+ GD
Sbjct: 194 -EHMEKDTKVCDMALVIGTSLLVHPFADLPEIVPNKCQR-----VLINREPAGDFG-ERK 246
Query: 348 IDYQIESDCDEWVTELKK 365
D I DCD V L K
Sbjct: 247 KDIMILGDCDSQVRALCK 264
>Hs13775602 [BK] KOG2682 NAD-dependent histone deacetylases and class I
sirtuins (SIR2 family)
Length = 352
Score = 98.2 bits (243), Expect = 2e-20
Identities = 86/273 (31%), Positives = 124/273 (44%), Gaps = 55/273 (20%)
Query: 52 LSLSEYRETNENSELISQINRVIH--RSRKCAVLTGAGISCNAGIPDFRS-FEGLYRMVK 108
LSL +E + + + R + R R+ L GAGIS +AGIPDFRS GLY ++
Sbjct: 12 LSLGSQKERLLDELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSPSTGLYDNLE 71
Query: 109 EQ---YPDVNIRSGQDMFDISLFREEEKISVFASFMENLYSHTIQAKPTKTHEFIAHLKN 165
+ YP+ +F+IS F++ + F + + LY Q KPT H F+ LK+
Sbjct: 72 KYHLPYPEA-------IFEISYFKKHPE--PFFALAKELYPG--QFKPTICHYFMRLLKD 120
Query: 166 RGKLLRCYTQNIDGLEEMLGLQMSKSRDADQSFSIQWKNLDVVQLHGDLTTLSCTQCFKV 225
+G LLRCYTQNID LE + GL+ D+V+ HG T C
Sbjct: 121 KGLLLRCYTQNIDTLERIAGLEQE----------------DLVEAHGTFYTSHCVSASCR 164
Query: 226 FSWSRHW-KRCLKNGELPVCPKCLEKNNRRSIEGKRCLGHSGMLRPNIVLYGENHPNADF 284
+ W K + + P C C +++P+IV +GE+ P F
Sbjct: 165 HEYPLSWMKEKIFSEVTPKCEDC-----------------QSLVKPDIVFFGESLPARFF 207
Query: 285 ITQGLNMDINRGKPDLFLIMGTSLKVDGVKRLV 317
M + K DL L+MGTSL+V L+
Sbjct: 208 SC----MQSDFLKVDLLLVMGTSLQVQPFASLI 236
>Hs13775600 [BK] KOG2682 NAD-dependent histone deacetylases and class I
sirtuins (SIR2 family)
Length = 389
Score = 98.2 bits (243), Expect = 2e-20
Identities = 86/273 (31%), Positives = 124/273 (44%), Gaps = 55/273 (20%)
Query: 52 LSLSEYRETNENSELISQINRVIH--RSRKCAVLTGAGISCNAGIPDFRS-FEGLYRMVK 108
LSL +E + + + R + R R+ L GAGIS +AGIPDFRS GLY ++
Sbjct: 49 LSLGSQKERLLDELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSPSTGLYDNLE 108
Query: 109 EQ---YPDVNIRSGQDMFDISLFREEEKISVFASFMENLYSHTIQAKPTKTHEFIAHLKN 165
+ YP+ +F+IS F++ + F + + LY Q KPT H F+ LK+
Sbjct: 109 KYHLPYPEA-------IFEISYFKKHPE--PFFALAKELYPG--QFKPTICHYFMRLLKD 157
Query: 166 RGKLLRCYTQNIDGLEEMLGLQMSKSRDADQSFSIQWKNLDVVQLHGDLTTLSCTQCFKV 225
+G LLRCYTQNID LE + GL+ D+V+ HG T C
Sbjct: 158 KGLLLRCYTQNIDTLERIAGLEQE----------------DLVEAHGTFYTSHCVSASCR 201
Query: 226 FSWSRHW-KRCLKNGELPVCPKCLEKNNRRSIEGKRCLGHSGMLRPNIVLYGENHPNADF 284
+ W K + + P C C +++P+IV +GE+ P F
Sbjct: 202 HEYPLSWMKEKIFSEVTPKCEDC-----------------QSLVKPDIVFFGESLPARFF 244
Query: 285 ITQGLNMDINRGKPDLFLIMGTSLKVDGVKRLV 317
M + K DL L+MGTSL+V L+
Sbjct: 245 SC----MQSDFLKVDLLLVMGTSLQVQPFASLI 273
>SPBC16D10.07c [BK] KOG2684 Sirtuin 5 and related class III sirtuins (SIR2 family)
Length = 471
Score = 95.9 bits (237), Expect = 1e-19
Identities = 76/265 (28%), Positives = 119/265 (44%), Gaps = 45/265 (16%)
Query: 73 VIHRSRKCAVLTGAGISCNAGIPDFRSFEGLYRMVKEQYPDVNIRSGQDMFDISLFREEE 132
++ +++ VL GAGIS + GI DFRS G Y + + +MFDI FRE
Sbjct: 148 LLKKAKNVVVLVGAGISTSLGILDFRSDNGFYARLARH----GLSEPSEMFDIHTFRENP 203
Query: 133 KISVFASFMENLYSHTIQAKPTKTHEFIAHLKNRGKLLRCYTQNIDGLEEMLGLQMSKSR 192
+I F +F +L T P+ H FI L+ + KL +TQNID LE+ GL +K
Sbjct: 204 EI--FYTFARDLLPETNHYSPS--HAFIRLLEKKNKLSTLFTQNIDNLEKKTGLSDNK-- 257
Query: 193 DADQSFSIQWKNLDVVQLHGDLTTLSCTQCFKVFSWSRHWKRCLKNGELPVCPKC----- 247
++Q HG T +C +C S ++ ++N + C +C
Sbjct: 258 --------------IIQCHGSFATATCIKCKHKVDGSELYED-IRNQRVSYCNECGKPPL 302
Query: 248 ----LEKNNRR--------SIEGKRCLGHSGMLRPNIVLYGENHPNADFITQGLNMDINR 295
+ +N + S + L G+++P+I +GE P++ F G
Sbjct: 303 KLRRVGQNKKEKHYFSDGDSESSEDDLAQPGIMKPDITFFGEALPDSFFNKVGSG---EL 359
Query: 296 GKPDLFLIMGTSLKVDGVKRLVKTI 320
+ DL + +GTSLKV V L+ I
Sbjct: 360 EETDLLICIGTSLKVAPVSELISVI 384
>YPL015c [BK] KOG2682 NAD-dependent histone deacetylases and class I
sirtuins (SIR2 family)
Length = 357
Score = 67.4 bits (163), Expect = 4e-11
Identities = 70/276 (25%), Positives = 119/276 (42%), Gaps = 60/276 (21%)
Query: 79 KCAVLTGAGISCNAGIPDFRS-FEGLYR---MVKEQYPDVNIRSGQDMFDISLFREEEKI 134
K + GAGIS + GIPDFRS GLY +K YP+ +FD+ F+ +
Sbjct: 26 KVIFMVGAGISTSCGIPDFRSPGTGLYHNLARLKLPYPEA-------VFDVDFFQSDPL- 77
Query: 135 SVFASFMENLYSHTIQAKPTKTHEFIAHLKNRGKLLRCYTQNIDGLEEMLGLQMSKSRDA 194
F + + LY +P+K H + +++ L R YTQNID LE G+
Sbjct: 78 -PFYTLAKELYPGNF--RPSKFHYLLKLFQDKDVLKRVYTQNIDTLERQAGV-------- 126
Query: 195 DQSFSIQWKNLDVVQLHGDLTTLSCTQCFKVFSWSRHWKRCLKNGELPVCPKCLEKNNRR 254
K+ +++ HG C C KV+ + +K L + KC
Sbjct: 127 --------KDDLIIEAHGSFAHCHCIGCGKVYP-PQVFKSKLAEHPIKDFVKC------- 170
Query: 255 SIEGKRCLGHSGMLRPNIVLYGENHP---------NADFITQGLNMDINRGKPDLFLIMG 305
+ G+ +++P IV +GE+ P +++++ + + + L +++G
Sbjct: 171 DVCGE-------LVKPAIVFFGEDLPDSFSETWLNDSEWLREKITTSGKHPQQPLVIVVG 223
Query: 306 TSLKVDGVKRLVKTISKQVHDRGGLVILINKTSIGD 341
TSL V L + I ++V +L N ++GD
Sbjct: 224 TSLAVYPFASLPEEIPRKVKR-----VLCNLETVGD 254
>Hs6912662 [BK] KOG2683 Sirtuin 4 and related class II sirtuins (SIR2 family)
Length = 314
Score = 63.5 bits (153), Expect = 6e-10
Identities = 68/272 (25%), Positives = 115/272 (42%), Gaps = 56/272 (20%)
Query: 65 ELISQINRVIHRSRKCAVLTGAGISCNAGIPDFRSFE-GLYRMVKEQYPDVNIRSGQDMF 123
E + ++ R I S++ V+TGAGIS +GIPD+RS + GLY + I+ G D
Sbjct: 42 EKVKELQRFITLSKRLLVMTGAGISTESGIPDYRSEKVGLYARTDRR----PIQHG-DFV 96
Query: 124 DISLFREEEKISVFASFMENLYSHTIQAKPTKTHEFIAHLKNRGKLLRCYTQNIDGLEEM 183
+ R+ F + + SH +P H ++ + GKL TQN+D L
Sbjct: 97 RSAPIRQRYWARNFVGWPQ-FSSH----QPNPAHWALSTWEKLGKLYWLVTQNVDALHTK 151
Query: 184 LGLQMSKSRDADQSFSIQWKNLDVVQLHGDLTTLSCTQC------------FKVF--SWS 229
G + + +LHG + + C C F+V +WS
Sbjct: 152 AGSRR------------------LTELHGCMDRVLCLDCGEQTPRGVLQERFQVLNPTWS 193
Query: 230 RHWKRCLKNGELPVCPKCLEKNNRRSIEGKRCLGHSGMLRPNIVLYGE--NHPNADFITQ 287
+G++ L + RS + C+ G L+P++V +G+ N DF+ +
Sbjct: 194 AEAHGLAPDGDV-----FLSEEQVRSFQVPTCVQCGGHLKPDVVFFGDTVNPDKVDFVHK 248
Query: 288 GLNMDINRGKPDLFLIMGTSLKVDGVKRLVKT 319
+ + D L++G+SL+V R + T
Sbjct: 249 RVK------EADSLLVVGSSLQVYSGYRFILT 274
>7299319 [BK] KOG1905 Class IV sirtuins (SIR2 family)
Length = 317
Score = 62.0 bits (149), Expect = 2e-09
Identities = 63/248 (25%), Positives = 107/248 (42%), Gaps = 59/248 (23%)
Query: 64 SELISQINRVIHRSRKCAVLTGAGISCNAGIPDFRSFEGLYRMV-KEQYPDVNIRSGQDM 122
+E ++ +I +S + TGAGIS +AGIPDFR +G++ + K + PD N+
Sbjct: 31 AEKCQELAELIKKSGHVVLHTGAGISTSAGIPDFRGPKGVWTLEEKGEKPDFNVS----- 85
Query: 123 FDISLFREEEKISVFASFMENLYSHTIQAKPTKTHEFIAHLKNRGKLLRCYTQNIDGLEE 182
FD +A+PTKTH I L G + +QNIDGL
Sbjct: 86 FD-------------------------EARPTKTHMAIIALIESGYVQYVISQNIDGLHL 120
Query: 183 MLGLQMSKSRDADQSFSIQWKNLDVVQLHGDLTTLSCTQCFKVFSWSRHWKRCLKNGELP 242
GL D+ + + +LHG++ C +C + F +
Sbjct: 121 KSGL--------DRKY--------LSELHGNIYIEQCKKCRRQF--------VSPSAVET 156
Query: 243 VCPKCLEKNNRRSIEGKRCLGHSGMLRPNIVLYGENHPNADFITQGLNMDINRGKPDLFL 302
V K L++ + S++ K SG+L N++ + + P D ++ + DL +
Sbjct: 157 VGQKSLQRACKSSMDSKGRSCRSGILYDNVLDWEHDLPENDLEMGVMHSTV----ADLNI 212
Query: 303 IMGTSLKV 310
+GT+L++
Sbjct: 213 ALGTTLQI 220
>Hs6912664 [BK] KOG2684 Sirtuin 5 and related class III sirtuins (SIR2 family)
Length = 310
Score = 54.7 bits (130), Expect = 3e-07
Identities = 64/259 (24%), Positives = 106/259 (40%), Gaps = 59/259 (22%)
Query: 64 SELISQINRVIHRSRKCAVLTGAGISCNAGIPDFRSFEGLYRMVKEQYPDVNIRSGQDMF 123
S ++ + +++ +++GAG+S +G+P FR G +R K Q D+
Sbjct: 37 SSSMADFRKFFAKAKHIVIISGAGVSAESGVPTFRGAGGYWR--KWQAQDL-------AT 87
Query: 124 DISLFREEEKISVFASFMENLYSHTIQAKPTKTHEFIAHLKNR----GKLLRCYTQNIDG 179
++ ++ F + + +P H IA + R G+ + TQNID
Sbjct: 88 PLAFAHNPSRVWEFYHYRREVMG---SKEPNAGHRAIAECETRLGKQGRRVVVITQNIDE 144
Query: 180 LEEMLGLQMSKSRDADQSFSIQWKNLDVVQLHGDLTTLSCTQCFKVFSWSRHWKRCLKNG 239
L G KNL +++HG L CT C V +N
Sbjct: 145 LHRKAGT----------------KNL--LEIHGSLFKTRCTSCGVV----------AENY 176
Query: 240 ELPVCPKCLEK------NNRRSIEGK---RC--LGHSGMLRPNIVLYGENHPNADFITQG 288
+ P+CP K SI + RC G G+LRP++V +GEN A I +
Sbjct: 177 KSPICPALSGKGAPEPGTQDASIPVEKLPRCEEAGCGGLLRPHVVWFGENLDPA--ILEE 234
Query: 289 LNMDINRGKPDLFLIMGTS 307
++ ++ DL L++GTS
Sbjct: 235 VDREL--AHCDLCLVVGTS 251
>Hs13787215 [BK] KOG2684 Sirtuin 5 and related class III sirtuins (SIR2 family)
Length = 299
Score = 54.7 bits (130), Expect = 3e-07
Identities = 64/259 (24%), Positives = 106/259 (40%), Gaps = 59/259 (22%)
Query: 64 SELISQINRVIHRSRKCAVLTGAGISCNAGIPDFRSFEGLYRMVKEQYPDVNIRSGQDMF 123
S ++ + +++ +++GAG+S +G+P FR G +R K Q D+
Sbjct: 37 SSSMADFRKFFAKAKHIVIISGAGVSAESGVPTFRGAGGYWR--KWQAQDL-------AT 87
Query: 124 DISLFREEEKISVFASFMENLYSHTIQAKPTKTHEFIAHLKNR----GKLLRCYTQNIDG 179
++ ++ F + + +P H IA + R G+ + TQNID
Sbjct: 88 PLAFAHNPSRVWEFYHYRREVMG---SKEPNAGHRAIAECETRLGKQGRRVVVITQNIDE 144
Query: 180 LEEMLGLQMSKSRDADQSFSIQWKNLDVVQLHGDLTTLSCTQCFKVFSWSRHWKRCLKNG 239
L G KNL +++HG L CT C V +N
Sbjct: 145 LHRKAGT----------------KNL--LEIHGSLFKTRCTSCGVV----------AENY 176
Query: 240 ELPVCPKCLEK------NNRRSIEGK---RC--LGHSGMLRPNIVLYGENHPNADFITQG 288
+ P+CP K SI + RC G G+LRP++V +GEN A I +
Sbjct: 177 KSPICPALSGKGAPEPGTQDASIPVEKLPRCEEAGCGGLLRPHVVWFGENLDPA--ILEE 234
Query: 289 LNMDINRGKPDLFLIMGTS 307
++ ++ DL L++GTS
Sbjct: 235 VDREL--AHCDLCLVVGTS 251
>At5g55760 [BK] KOG1905 Class IV sirtuins (SIR2 family)
Length = 473
Score = 54.3 bits (129), Expect = 4e-07
Identities = 66/288 (22%), Positives = 113/288 (38%), Gaps = 72/288 (25%)
Query: 67 ISQINRVIHRSRKCAVLTGAGISCNAGIPDFRSFEGLYRMVKEQYPDVNIRSGQDMFDIS 126
I ++ ++I +S+ V TGAGIS + GIPDFR +G++ + +E G+D+ S
Sbjct: 34 IEELAKLIQKSKHLVVFTGAGISTSCGIPDFRGPKGIWTLQRE---------GKDLPKAS 84
Query: 127 LFREEEKISVFASFMENLYSHTIQAKPTKTHEFIAHLKNRGKLLRCYTQNIDGLEEMLGL 186
L +A P+ TH + L+ G L +QN+DGL G+
Sbjct: 85 L-------------------PFHRAMPSMTHMALVELERAGILKFVISQNVDGLHLRSGI 125
Query: 187 QMSKSRDADQSFSIQWKNLDVVQLHGDLTTLSCTQCFKVFSWSRHWKRCLKNGELPVCPK 246
K + +LHGD C C + L++ E+
Sbjct: 126 PREK----------------LSELHGDSFMEMCPSCGAEY---------LRDFEVETIGL 160
Query: 247 CLEKNNRRSIEGKRCLGHSGMLRPNIVLYGENHPNADFITQGLNMDINRGKPDLFLIMGT 306
K R ++C L+ ++ + + P + + + K DL L +GT
Sbjct: 161 ---KETSRKCSVEKC---GAKLKDTVLDWEDALPPKEIDP----AEKHCKKADLVLCLGT 210
Query: 307 SLKVDGVKRLVKTISKQVHDRGGLVILIN-----KTSIGDCNWHGIID 349
SL++ L K GG ++++N K + HG++D
Sbjct: 211 SLQITPACNLPLKCLK----GGGKIVIVNLQKTPKDKKANVVIHGLVD 254
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.319 0.134 0.393
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,420,874
Number of Sequences: 60738
Number of extensions: 1049349
Number of successful extensions: 3430
Number of sequences better than 1.0e-05: 20
Number of HSP's better than 0.0 without gapping: 5
Number of HSP's successfully gapped in prelim test: 15
Number of HSP's that attempted gapping in prelim test: 3361
Number of HSP's gapped (non-prelim): 21
length of query: 459
length of database: 30,389,216
effective HSP length: 110
effective length of query: 349
effective length of database: 23,708,036
effective search space: 8274104564
effective search space used: 8274104564
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)