ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactI1943 check: MH T KOG0578 Signal transduction mechanisms p21-activated serine/threonine protein kinase
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactI1943 661261 663897 879
(879 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YNL298w [T] KOG0578 p21-activated serine/threonine protein kinase 833 0.0
YOL113w [T] KOG0578 p21-activated serine/threonine protein kinase 400 e-111
SPAC1F5.09c [T] KOG0578 p21-activated serine/threonine protein k... 334 3e-91
YHL007c [T] KOG0578 p21-activated serine/threonine protein kinase 332 1e-90
Hs4505599 [T] KOG0578 p21-activated serine/threonine protein kinase 323 9e-88
Hs7382496 [T] KOG0578 p21-activated serine/threonine protein kinase 322 1e-87
Hs4505601 [T] KOG0578 p21-activated serine/threonine protein kinase 318 3e-86
7298926 [T] KOG0578 p21-activated serine/threonine protein kinase 311 3e-84
SPBC1604.14c [T] KOG0578 p21-activated serine/threonine protein ... 307 4e-83
CE27670 [T] KOG0578 p21-activated serine/threonine protein kinase 305 3e-82
7300149 [T] KOG0578 p21-activated serine/threonine protein kinase 291 3e-78
CE21615 [T] KOG0578 p21-activated serine/threonine protein kinase 278 2e-74
Hs5031975 [T] KOG0578 p21-activated serine/threonine protein kinase 238 3e-62
Hs14771959 [T] KOG0578 p21-activated serine/threonine protein ki... 234 3e-61
CE20564 [T] KOG0578 p21-activated serine/threonine protein kinase 234 3e-61
CE05425 [T] KOG0578 p21-activated serine/threonine protein kinase 234 3e-61
Hs18602554 [T] KOG0578 p21-activated serine/threonine protein ki... 233 1e-60
Hs9910476 [T] KOG0578 p21-activated serine/threonine protein kinase 232 2e-60
CE27965 [T] KOG0574 STE20-like serine/threonine kinase MST 202 2e-51
CE27726 [T] KOG0574 STE20-like serine/threonine kinase MST 202 2e-51
CE27082 [T] KOG0574 STE20-like serine/threonine kinase MST 202 2e-51
CE07064 [T] KOG0574 STE20-like serine/threonine kinase MST 202 2e-51
At1g69220 [T] KOG0576 Mitogen-activated protein kinase kinase ki... 200 9e-51
Hs5454096 [T] KOG0574 STE20-like serine/threonine kinase MST 199 2e-50
7291778 [T] KOG0579 Ste20-like serine/threonine protein kinase 199 2e-50
Hs20070158 [T] KOG0201 Serine/threonine protein kinase 197 8e-50
Hs5454094 [T] KOG0574 STE20-like serine/threonine kinase MST 196 1e-49
Hs16178962 [T] KOG0574 STE20-like serine/threonine kinase MST 196 1e-49
7292249 [T] KOG0587 Traf2- and Nck-interacting kinase and relate... 192 1e-48
CE28674 [T] KOG0201 Serine/threonine protein kinase 192 2e-48
7302458 [T] KOG0574 STE20-like serine/threonine kinase MST 191 3e-48
HsM5454174 [T] KOG0201 Serine/threonine protein kinase 191 4e-48
Hs21361358 [T] KOG0201 Serine/threonine protein kinase 191 4e-48
CE07510 [T] KOG0201 Serine/threonine protein kinase 189 2e-47
HsM4758524 [T] KOG0587 Traf2- and Nck-interacting kinase and rel... 188 3e-47
Hs22035606 [T] KOG0587 Traf2- and Nck-interacting kinase and rel... 188 3e-47
Hs22035604 [T] KOG0587 Traf2- and Nck-interacting kinase and rel... 188 3e-47
Hs22035602 [T] KOG0587 Traf2- and Nck-interacting kinase and rel... 188 3e-47
7302511 [T] KOG0576 Mitogen-activated protein kinase kinase kina... 188 3e-47
Hs8393810_1 [T] KOG0587 Traf2- and Nck-interacting kinase and re... 188 3e-47
Hs20544910_1 [T] KOG0587 Traf2- and Nck-interacting kinase and r... 188 3e-47
Hs15451902 [T] KOG0576 Mitogen-activated protein kinase kinase k... 188 4e-47
Hs14589909 [T] KOG0576 Mitogen-activated protein kinase kinase k... 186 2e-46
CE28273 [T] KOG0587 Traf2- and Nck-interacting kinase and relate... 185 2e-46
CE25673 [T] KOG0587 Traf2- and Nck-interacting kinase and relate... 185 2e-46
CE25672 [T] KOG0587 Traf2- and Nck-interacting kinase and relate... 185 2e-46
Hs15011880 [T] KOG0201 Serine/threonine protein kinase 184 4e-46
At3g15220 [T] KOG0201 Serine/threonine protein kinase 183 9e-46
Hs7657335 [T] KOG0587 Traf2- and Nck-interacting kinase and rela... 181 6e-45
Hs7661994 [T] KOG0579 Ste20-like serine/threonine protein kinase 179 2e-44
7300224 [T] KOG0201 Serine/threonine protein kinase 179 2e-44
At1g53165 [T] KOG0201 Serine/threonine protein kinase 176 1e-43
Hs5174701 [T] KOG0579 Ste20-like serine/threonine protein kinase 174 4e-43
Hs20428779_1 [T] KOG0587 Traf2- and Nck-interacting kinase and r... 174 5e-43
CE07599 [T] KOG0576 Mitogen-activated protein kinase kinase kina... 174 7e-43
Hs22035600 [T] KOG0576 Mitogen-activated protein kinase kinase k... 173 9e-43
Hs6005810 [T] KOG0576 Mitogen-activated protein kinase kinase ki... 173 1e-42
HsM4759010 [T] KOG0576 Mitogen-activated protein kinase kinase k... 172 2e-42
At3g07980 [T] KOG0198 MEKK and related serine/threonine protein ... 168 4e-41
SPBC17F3.02 [T] KOG0201 Serine/threonine protein kinase 167 7e-41
Hs19923464 [T] KOG0577 Serine/threonine protein kinase 167 7e-41
YHR102w [T] KOG0201 Serine/threonine protein kinase 167 9e-41
SPAC9G1.09 [T] KOG0201 Serine/threonine protein kinase 165 3e-40
At3g13530 [T] KOG0198 MEKK and related serine/threonine protein ... 162 2e-39
7297240_1 [T] KOG0587 Traf2- and Nck-interacting kinase and rela... 160 8e-39
Hs4826878 [T] KOG0582 Ste20-like serine/threonine protein kinase 160 1e-38
Hs7706401 [T] KOG0577 Serine/threonine protein kinase 157 5e-38
Hs4759208 [T] KOG0577 Serine/threonine protein kinase 157 5e-38
SPAC2C4.14c [T] KOG0201 Serine/threonine protein kinase 155 2e-37
At5g14720 [T] KOG0582 Ste20-like serine/threonine protein kinase 154 6e-37
7293601 [T] KOG0577 Serine/threonine protein kinase 154 7e-37
SPBC1D7.05c [T] KOG0198 MEKK and related serine/threonine protei... 151 5e-36
Hs7019543 [T] KOG0582 Ste20-like serine/threonine protein kinase 150 8e-36
YDR523c [T] KOG0201 Serine/threonine protein kinase 149 1e-35
YLR362w [T] KOG0198 MEKK and related serine/threonine protein ki... 149 2e-35
SPBC21.06c [T] KOG0198 MEKK and related serine/threonine protein... 147 5e-35
SPAC1F3.02c [T] KOG0198 MEKK and related serine/threonine protei... 147 7e-35
CE26212 [T] KOG0582 Ste20-like serine/threonine protein kinase 146 2e-34
CE07905 [T] KOG0579 Ste20-like serine/threonine protein kinase 145 3e-34
CE01405 [T] KOG0577 Serine/threonine protein kinase 145 3e-34
Hs22065589 [T] KOG0587 Traf2- and Nck-interacting kinase and rel... 144 5e-34
At3g06030 [T] KOG0198 MEKK and related serine/threonine protein ... 141 4e-33
Hs4505153 [T] KOG0198 MEKK and related serine/threonine protein ... 141 5e-33
At1g53570 [T] KOG0198 MEKK and related serine/threonine protein ... 140 9e-33
YAR019c [T] KOG0198 MEKK and related serine/threonine protein ki... 139 2e-32
Hs22045241 [T] KOG0578 p21-activated serine/threonine protein ki... 139 2e-32
At1g09000 [T] KOG0198 MEKK and related serine/threonine protein ... 139 2e-32
7293247 [T] KOG0578 p21-activated serine/threonine protein kinase 137 6e-32
HsM5729922 [T] KOG0198 MEKK and related serine/threonine protein... 137 9e-32
At4g08500 [T] KOG0198 MEKK and related serine/threonine protein ... 136 2e-31
At4g14480 [T] KOG0582 Ste20-like serine/threonine protein kinase 135 3e-31
At4g24100 [T] KOG0582 Ste20-like serine/threonine protein kinase 135 4e-31
Hs22065797 [T] KOG0577 Serine/threonine protein kinase 134 6e-31
At4g12020_6 [T] KOG0198 MEKK and related serine/threonine protei... 134 8e-31
At4g10730 [T] KOG0582 Ste20-like serine/threonine protein kinase 133 1e-30
Hs21735556 [T] KOG0198 MEKK and related serine/threonine protein... 132 2e-30
At1g63700 [T] KOG0198 MEKK and related serine/threonine protein ... 130 7e-30
YJL095w [T] KOG0198 MEKK and related serine/threonine protein ki... 130 9e-30
SPAC23C11.16 [D] KOG0575 Polo-like serine/threonine protein kinase 130 1e-29
At4g29810 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 129 2e-29
At5g40440 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 129 3e-29
At4g08470 [T] KOG0198 MEKK and related serine/threonine protein ... 127 1e-28
At4g08480 [T] KOG0198 MEKK and related serine/threonine protein ... 126 1e-28
At1g54960 [T] KOG0198 MEKK and related serine/threonine protein ... 126 1e-28
Hs4758016 [D] KOG0575 Polo-like serine/threonine protein kinase 126 2e-28
At4g26890 [T] KOG0198 MEKK and related serine/threonine protein ... 126 2e-28
At5g66850 [T] KOG0198 MEKK and related serine/threonine protein ... 125 2e-28
Hs18552621 [R] KOG0597 Serine-threonine protein kinase FUSED 125 3e-28
Hs5174547 [T] KOG4279 Serine/threonine protein kinase 125 4e-28
Hs5032091 [RT] KOG0598 Ribosomal protein S6 kinase and related p... 124 6e-28
Hs20149547 [T] KOG0603 Ribosomal protein S6 kinase 124 6e-28
At1g70430 [T] KOG0582 Ste20-like serine/threonine protein kinase 123 1e-27
At3g61960 [OUT] KOG0595 Serine/threonine-protein kinase involved... 123 1e-27
7290841 [D] KOG0591 NIMA (never in mitosis)-related G2-specific ... 123 1e-27
7300559 [T] KOG4279 Serine/threonine protein kinase 122 2e-27
At1g50230 [R] KOG0597 Serine-threonine protein kinase FUSED 122 3e-27
Hs20550407 [T] KOG0201 Serine/threonine protein kinase 121 4e-27
CE18699 [T] KOG0694 Serine/threonine protein kinase 121 4e-27
At5g56580 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 121 4e-27
YDL159w [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K) 121 5e-27
Hs4502023 [T] KOG0690 Serine/threonine protein kinase 121 5e-27
7290147 [T] KOG0583 Serine/threonine protein kinase 121 5e-27
YMR001c [D] KOG0575 Polo-like serine/threonine protein kinase 120 9e-27
7302860 [T] KOG0696 Serine/threonine protein kinase 120 9e-27
YJL164c [T] KOG0616 cAMP-dependent protein kinase catalytic subu... 120 1e-26
Hs4885549 [T] KOG0690 Serine/threonine protein kinase 120 1e-26
Hs4507831 [OUT] KOG0595 Serine/threonine-protein kinase involved... 120 1e-26
Hs20127541 [RT] KOG0598 Ribosomal protein S6 kinase and related ... 120 1e-26
At2g45490 [D] KOG0580 Serine/threonine protein kinase 120 1e-26
7301213 [R] KOG0589 Serine/threonine protein kinase 120 1e-26
Hs4826948 [T] KOG0616 cAMP-dependent protein kinase catalytic su... 119 2e-26
CE27177 [T] KOG4279 Serine/threonine protein kinase 119 2e-26
CE02586 [T] KOG0696 Serine/threonine protein kinase 119 2e-26
7302464 [R] KOG0586 Serine/threonine protein kinase 119 2e-26
CE25046 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-... 119 2e-26
YKL101w [D] KOG0588 Serine/threonine protein kinase 117 6e-26
Hs5453974 [T] KOG0694 Serine/threonine protein kinase 117 6e-26
Hs4759050 [T] KOG0603 Ribosomal protein S6 kinase 117 6e-26
Hs13899225 [R] KOG0586 Serine/threonine protein kinase 117 8e-26
Hs13384594 [T] KOG0696 Serine/threonine protein kinase 117 8e-26
CE24516 [OUT] KOG0595 Serine/threonine-protein kinase involved i... 117 8e-26
7303915 [T] KOG0694 Serine/threonine protein kinase 117 8e-26
7303914 [T] KOG0694 Serine/threonine protein kinase 117 8e-26
7299536 [D] KOG0580 Serine/threonine protein kinase 117 8e-26
SPBC12D12.04c [T] KOG0694 Serine/threonine protein kinase 117 1e-25
Hs5730055 [D] KOG0575 Polo-like serine/threonine protein kinase 117 1e-25
At2g31010 [T] KOG0192 Tyrosine kinase specific for activated (GT... 116 1e-25
Hs4758702 [T] KOG4279 Serine/threonine protein kinase 116 2e-25
Hs15619015 [T] KOG0616 cAMP-dependent protein kinase catalytic s... 116 2e-25
Hs22062450 [R] KOG0586 Serine/threonine protein kinase 115 2e-25
YKL166c [T] KOG0616 cAMP-dependent protein kinase catalytic subu... 115 3e-25
Hs7657526 [T] KOG0603 Ribosomal protein S6 kinase 115 3e-25
Hs4885563 [T] KOG0694 Serine/threonine protein kinase 115 3e-25
Hs4885061 [T] KOG0690 Serine/threonine protein kinase 115 4e-25
Hs4506067 [T] KOG0696 Serine/threonine protein kinase 115 4e-25
Hs4505373 [V] KOG1826 Ras GTPase activating protein RasGAP/neuro... 115 4e-25
Hs22057171 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase ... 115 4e-25
Hs20479818 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase ... 115 4e-25
CE29092 [T] KOG0694 Serine/threonine protein kinase 115 4e-25
Hs14993776 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase ... 114 5e-25
CE15475 [T] KOG0616 cAMP-dependent protein kinase catalytic subu... 114 5e-25
CE15473 [T] KOG0616 cAMP-dependent protein kinase catalytic subu... 114 5e-25
Hs9845489 [R] KOG0586 Serine/threonine protein kinase 114 7e-25
Hs9845487 [R] KOG0586 Serine/threonine protein kinase 114 7e-25
CE27768 [R] KOG0586 Serine/threonine protein kinase 114 7e-25
CE23838 [R] KOG0586 Serine/threonine protein kinase 114 7e-25
SPCC320.12c [D] KOG0580 Serine/threonine protein kinase 114 9e-25
Hs8923922 [R] KOG0586 Serine/threonine protein kinase 114 9e-25
Hs20535816 [T] KOG0695 Serine/threonine protein kinase 114 9e-25
Hs19923570 [T] KOG0603 Ribosomal protein S6 kinase 114 9e-25
Hs10864650 [T] KOG0695 Serine/threonine protein kinase 114 9e-25
YPL203w [T] KOG0616 cAMP-dependent protein kinase catalytic subu... 113 1e-24
Hs10835065 [T] KOG0616 cAMP-dependent protein kinase catalytic s... 113 1e-24
CE23702 [T] KOG4721 Serine/threonine protein kinase contains leu... 113 1e-24
At3g04530 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 113 1e-24
HsM4505103 [R] KOG0586 Serine/threonine protein kinase 113 1e-24
At5g01810 [T] KOG0583 Serine/threonine protein kinase 113 1e-24
At2g32510 [T] KOG0198 MEKK and related serine/threonine protein ... 112 2e-24
7301734 [T] KOG0694 Serine/threonine protein kinase 112 2e-24
Hs4506057 [T] KOG0616 cAMP-dependent protein kinase catalytic su... 112 3e-24
CE17284 [T] KOG0583 Serine/threonine protein kinase 112 3e-24
At5g55090 [T] KOG0198 MEKK and related serine/threonine protein ... 112 3e-24
At2g17700 [T] KOG0192 Tyrosine kinase specific for activated (GT... 112 3e-24
YGL180w [OUT] KOG0595 Serine/threonine-protein kinase involved i... 111 4e-24
HsM4826916 [D] KOG0575 Polo-like serine/threonine protein kinase 111 4e-24
Hs4506055 [T] KOG0616 cAMP-dependent protein kinase catalytic su... 111 4e-24
CE24761 [D] KOG0580 Serine/threonine protein kinase 111 4e-24
At5g39440 [T] KOG0583 Serine/threonine protein kinase 111 4e-24
At2g42630 [T] KOG0192 Tyrosine kinase specific for activated (GT... 111 4e-24
Hs7662210 [OUT] KOG0595 Serine/threonine-protein kinase involved... 111 6e-24
CE21879 [D] KOG0590 Checkpoint kinase and related serine/threoni... 111 6e-24
Hs21359873 [D] KOG0575 Polo-like serine/threonine protein kinase 110 7e-24
Hs14777335 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase ... 110 7e-24
At4g26070 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 110 7e-24
7297542 [T] KOG0616 cAMP-dependent protein kinase catalytic subu... 110 7e-24
7293496 [R] KOG0597 Serine-threonine protein kinase FUSED 110 7e-24
7292679 [G] KOG0599 Phosphorylase kinase gamma subunit 110 7e-24
Hs4507273 [D] KOG0580 Serine/threonine protein kinase 110 9e-24
7295638 [T] KOG0603 Ribosomal protein S6 kinase 110 9e-24
CE13014 [T] KOG0603 Ribosomal protein S6 kinase 110 1e-23
7304311 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-... 110 1e-23
7298652 [D] KOG0615 Serine/threonine protein kinase Chk2 and rel... 110 1e-23
Hs7019489 [T] KOG0694 Serine/threonine protein kinase 109 2e-23
Hs6031180 [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and... 109 2e-23
Hs5803088 [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and... 109 2e-23
Hs5453976 [T] KOG0694 Serine/threonine protein kinase 109 2e-23
Hs14196445 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase ... 109 2e-23
CE18169 [T] KOG0603 Ribosomal protein S6 kinase 109 2e-23
Hs20070247_2 [RT] KOG0598 Ribosomal protein S6 kinase and relate... 109 2e-23
Hs4506101 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 109 2e-23
Hs21729897 [T] KOG0581 Mitogen-activated protein kinase kinase (... 109 2e-23
CE27583 [T] KOG0604 MAP kinase-activated protein kinase 2 109 2e-23
SPBC106.10 [T] KOG0616 cAMP-dependent protein kinase catalytic s... 108 3e-23
Hs21729895 [T] KOG0581 Mitogen-activated protein kinase kinase (... 108 3e-23
Hs14728804 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase ... 108 3e-23
CE17545 [T] KOG0604 MAP kinase-activated protein kinase 2 108 3e-23
7304283 [Z] KOG0613 Projectin/twitchin and related proteins 108 3e-23
SPAC9G1.02 [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 an... 108 4e-23
Hs4758652 [R] KOG0593 Predicted protein kinase KKIAMRE 108 4e-23
7302861 [T] KOG0696 Serine/threonine protein kinase 108 4e-23
7294537 [OUT] KOG0595 Serine/threonine-protein kinase involved i... 108 4e-23
7293666 [D] KOG0575 Polo-like serine/threonine protein kinase 108 4e-23
YDR122w [T] KOG0583 Serine/threonine protein kinase 108 5e-23
SPBC4F6.06 [T] KOG0583 Serine/threonine protein kinase 108 5e-23
Hs4506073 [T] KOG0694 Serine/threonine protein kinase 108 5e-23
Hs21361133 [R] KOG0586 Serine/threonine protein kinase 108 5e-23
Hs14758219 [T] KOG0694 Serine/threonine protein kinase 108 5e-23
At5g45820 [T] KOG0583 Serine/threonine protein kinase 108 5e-23
At3g20860 [R] KOG0589 Serine/threonine protein kinase 108 5e-23
YPL209c [D] KOG0580 Serine/threonine protein kinase 107 6e-23
YOR231w [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K) 107 6e-23
CE02377 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-... 107 6e-23
At3g29160 [T] KOG0583 Serine/threonine protein kinase 107 6e-23
At2g37840 [OUT] KOG0595 Serine/threonine-protein kinase involved... 107 6e-23
At2g25090 [T] KOG0583 Serine/threonine protein kinase 107 6e-23
At1g29230 [T] KOG0583 Serine/threonine protein kinase 107 6e-23
7299322 [R] KOG0611 Predicted serine/threonine protein kinase 107 6e-23
7290150 [T] KOG0583 Serine/threonine protein kinase 107 6e-23
YPL140c [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K) 107 8e-23
Hs4505569 [R] KOG0593 Predicted protein kinase KKIAMRE 107 8e-23
Hs22068916 [T] KOG0696 Serine/threonine protein kinase 107 8e-23
Hs21735544 [T] KOG0983 Mitogen-activated protein kinase (MAPK) k... 107 8e-23
Hs20127450 [T] KOG0696 Serine/threonine protein kinase 107 8e-23
ECU01g1320 [T] KOG0612 Rho-associated coiled-coil containing pro... 107 8e-23
7300106 [T] KOG0690 Serine/threonine protein kinase 107 8e-23
7299437 [R] KOG0586 Serine/threonine protein kinase 107 8e-23
Hs22050308_2 [T] KOG0198 MEKK and related serine/threonine prote... 107 8e-23
SPAC890.03 [T] KOG0583 Serine/threonine protein kinase 107 1e-22
Hs5453970 [T] KOG0694 Serine/threonine protein kinase 107 1e-22
ECU05g0630 [R] KOG0584 Serine/threonine protein kinase 107 1e-22
CE18967 [T] KOG4236 Serine/threonine protein kinase PKC mu/PKD a... 107 1e-22
CE16081 [T] KOG0583 Serine/threonine protein kinase 107 1e-22
CE14798 [RT] KOG0598 Ribosomal protein S6 kinase and related pro... 107 1e-22
At3g08720 [RT] KOG0598 Ribosomal protein S6 kinase and related p... 107 1e-22
At1g79640 [T] KOG0582 Ste20-like serine/threonine protein kinase 107 1e-22
YCR073c [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and r... 106 1e-22
SPCC18B5.11c [D] KOG0615 Serine/threonine protein kinase Chk2 an... 106 1e-22
Hs4506075 [T] KOG4236 Serine/threonine protein kinase PKC mu/PKD... 106 1e-22
Hs21735542 [T] KOG0983 Mitogen-activated protein kinase (MAPK) k... 106 1e-22
Hs14735945 [T] KOG0694 Serine/threonine protein kinase 106 1e-22
CE28744 [RT] KOG0598 Ribosomal protein S6 kinase and related pro... 106 1e-22
CE22045 [RT] KOG0598 Ribosomal protein S6 kinase and related pro... 106 1e-22
At5g25110 [T] KOG0583 Serine/threonine protein kinase 106 1e-22
At5g03730 [T] KOG0192 Tyrosine kinase specific for activated (GT... 106 1e-22
At3g08730 [RT] KOG0598 Ribosomal protein S6 kinase and related p... 106 1e-22
At2g30360 [T] KOG0583 Serine/threonine protein kinase 106 1e-22
At1g49180_1 [OUT] KOG0595 Serine/threonine-protein kinase involv... 106 1e-22
Hs5453964 [T] KOG0583 Serine/threonine protein kinase 106 2e-22
Hs20547806 [R] KOG0589 Serine/threonine protein kinase 106 2e-22
CE29298 [T] KOG0690 Serine/threonine protein kinase 106 2e-22
CE18646 [T] KOG0690 Serine/threonine protein kinase 106 2e-22
At4g35780 [T] KOG0192 Tyrosine kinase specific for activated (GT... 106 2e-22
At4g23050 [T] KOG0192 Tyrosine kinase specific for activated (GT... 106 2e-22
At4g18700 [T] KOG0583 Serine/threonine protein kinase 106 2e-22
7291037 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K) 106 2e-22
Hs4507277_1 [R] KOG0589 Serine/threonine protein kinase 105 2e-22
SPBC543.07 [T] KOG0581 Mitogen-activated protein kinase kinase (... 105 3e-22
Hs5453966 [T] KOG0583 Serine/threonine protein kinase 105 3e-22
Hs4507275 [D] KOG0580 Serine/threonine protein kinase 105 3e-22
ECU11g1500 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase ... 105 3e-22
YDR507c [D] KOG0588 Serine/threonine protein kinase 105 4e-22
YDL101c [D] KOG0615 Serine/threonine protein kinase Chk2 and rel... 105 4e-22
SPAC57A10.02 [D] KOG0588 Serine/threonine protein kinase 105 4e-22
Hs4506737 [RT] KOG0598 Ribosomal protein S6 kinase and related p... 105 4e-22
Hs19923407 [D] KOG0591 NIMA (never in mitosis)-related G2-specif... 105 4e-22
CE08098 [T] KOG0612 Rho-associated coiled-coil containing protei... 105 4e-22
Hs4502553 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 104 5e-22
Hs19923468 [T] KOG4236 Serine/threonine protein kinase PKC mu/PK... 104 5e-22
CE21025 [D] KOG0580 Serine/threonine protein kinase 104 5e-22
At5g45810 [T] KOG0583 Serine/threonine protein kinase 104 5e-22
Hs4758128_2 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase... 104 5e-22
Hs5031689 [T] KOG4236 Serine/threonine protein kinase PKC mu/PKD... 104 7e-22
Hs4505785 [G] KOG0599 Phosphorylase kinase gamma subunit 104 7e-22
Hs10835242 [T] KOG0614 cGMP-dependent protein kinase 104 7e-22
At4g33950 [T] KOG0583 Serine/threonine protein kinase 104 7e-22
At2g34180 [T] KOG0583 Serine/threonine protein kinase 104 7e-22
At1g10940 [T] KOG0583 Serine/threonine protein kinase 104 7e-22
HsM7657627 [D] KOG0575 Polo-like serine/threonine protein kinase 103 9e-22
Hs9966875 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 103 9e-22
Hs13376582 [T] KOG0198 MEKK and related serine/threonine protein... 103 9e-22
CE28643 [T] KOG0583 Serine/threonine protein kinase 103 9e-22
CE23001 [R] KOG0589 Serine/threonine protein kinase 103 9e-22
CE07458 [T] KOG0583 Serine/threonine protein kinase 103 9e-22
At4g40010 [T] KOG0583 Serine/threonine protein kinase 103 9e-22
At3g06620 [T] KOG0192 Tyrosine kinase specific for activated (GT... 103 9e-22
At2g25880 [D] KOG0580 Serine/threonine protein kinase 103 9e-22
At1g51660 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 103 9e-22
7299438 [R] KOG0586 Serine/threonine protein kinase 103 9e-22
HsM4507279 [D] KOG0580 Serine/threonine protein kinase 103 1e-21
Hs7705841 [T] KOG1187 Serine/threonine protein kinase 103 1e-21
Hs5453972 [T] KOG0694 Serine/threonine protein kinase 103 1e-21
Hs5453882 [G] KOG0599 Phosphorylase kinase gamma subunit 103 1e-21
Hs4759178 [D] KOG0580 Serine/threonine protein kinase 103 1e-21
Hs21729899 [T] KOG0581 Mitogen-activated protein kinase kinase (... 103 1e-21
Hs21361433 [D] KOG0575 Polo-like serine/threonine protein kinase 103 1e-21
Hs14768528 [T] KOG1187 Serine/threonine protein kinase 103 1e-21
Hs12711660 [R] KOG0584 Serine/threonine protein kinase 103 1e-21
At1g14000 [T] KOG0192 Tyrosine kinase specific for activated (GT... 103 1e-21
YLR096w [T] KOG0583 Serine/threonine protein kinase 103 2e-21
SPAC2F3.15 [D] KOG0600 Cdc2-related protein kinase 103 2e-21
SPAC1D4.13 [T] KOG0581 Mitogen-activated protein kinase kinase (... 103 2e-21
Hs4506529 [T] KOG0986 G protein-coupled receptor kinase 103 2e-21
CE10328 [T] KOG1006 Mitogen-activated protein kinase (MAPK) kina... 103 2e-21
At1g49160 [R] KOG0584 Serine/threonine protein kinase 103 2e-21
7293761 [T] KOG4721 Serine/threonine protein kinase contains leu... 103 2e-21
7290629 [T] KOG0604 MAP kinase-activated protein kinase 2 103 2e-21
Hs4506071 [T] KOG0695 Serine/threonine protein kinase 102 2e-21
Hs22043888 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase ... 102 2e-21
Hs21361643 [T] KOG4717 Serine/threonine protein kinase 102 2e-21
CE17354 [T] KOG0694 Serine/threonine protein kinase 102 2e-21
CE17353 [T] KOG0694 Serine/threonine protein kinase 102 2e-21
CE07285 [D] KOG0575 Polo-like serine/threonine protein kinase 102 2e-21
7299160 [OUT] KOG0595 Serine/threonine-protein kinase involved i... 102 2e-21
7295426 [RT] KOG0598 Ribosomal protein S6 kinase and related pro... 102 2e-21
YPL031c [R] KOG0594 Protein kinase PCTAIRE and related kinases 102 3e-21
YBL105c [T] KOG0694 Serine/threonine protein kinase 102 3e-21
CE15235 [R] KOG0589 Serine/threonine protein kinase 102 3e-21
CE09360 [Z] KOG0613 Projectin/twitchin and related proteins 102 3e-21
CE02604 [T] KOG0695 Serine/threonine protein kinase 102 3e-21
At5g49470 [T] KOG0192 Tyrosine kinase specific for activated (GT... 102 3e-21
At1g23700 [T] KOG0582 Ste20-like serine/threonine protein kinase 102 3e-21
At1g08650 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 102 3e-21
7303111 [T] KOG0695 Serine/threonine protein kinase 102 3e-21
Hs4758700 [T] KOG0604 MAP kinase-activated protein kinase 2 102 3e-21
Hs19923134 [T] KOG4250 TANK binding protein kinase TBK1 102 3e-21
CE28218 [D] KOG0588 Serine/threonine protein kinase 102 3e-21
At4g38470 [T] KOG0192 Tyrosine kinase specific for activated (GT... 102 3e-21
At3g01090 [T] KOG0583 Serine/threonine protein kinase 102 3e-21
7292830 [T] KOG0984 Mitogen-activated protein kinase (MAPK) kina... 102 3e-21
Hs19311016_1 [R] KOG0589 Serine/threonine protein kinase 102 3e-21
YOR351c [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-... 101 4e-21
YHR205w [RT] KOG0598 Ribosomal protein S6 kinase and related pro... 101 4e-21
Hs6005850 [D] KOG0615 Serine/threonine protein kinase Chk2 and r... 101 4e-21
Hs14916455 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase ... 101 4e-21
CE05780 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-... 101 4e-21
CE03467 [T] KOG0604 MAP kinase-activated protein kinase 2 101 4e-21
At5g08590 [T] KOG0583 Serine/threonine protein kinase 101 4e-21
At4g32830 [D] KOG0580 Serine/threonine protein kinase 101 4e-21
7291707 [T] KOG1152 Signal transduction serine/threonine kinase ... 101 4e-21
YCL024w [T] KOG0583 Serine/threonine protein kinase 101 6e-21
At5g35410 [T] KOG0583 Serine/threonine protein kinase 101 6e-21
At2g26980 [T] KOG0583 Serine/threonine protein kinase 101 6e-21
At1g73660 [T] KOG0192 Tyrosine kinase specific for activated (GT... 101 6e-21
SPACUNK12.02c [T] KOG0032 Ca2+/calmodulin-dependent protein kina... 100 8e-21
CE05274 [T] KOG0690 Serine/threonine protein kinase 100 8e-21
At5g66880 [T] KOG0583 Serine/threonine protein kinase 100 8e-21
Hs7661974 [T] KOG0583 Serine/threonine protein kinase 100 1e-20
ECU01g0630 [D] KOG0575 Polo-like serine/threonine protein kinase 100 1e-20
At5g07070 [T] KOG0583 Serine/threonine protein kinase 100 1e-20
At1g12580 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 100 1e-20
Hs7657214 [T] KOG0583 Serine/threonine protein kinase 100 1e-20
Hs22055520 [R] KOG0584 Serine/threonine protein kinase 100 1e-20
Hs19424132 [D] KOG0591 NIMA (never in mitosis)-related G2-specif... 100 1e-20
CE20636 [D] KOG0590 Checkpoint kinase and related serine/threoni... 100 1e-20
At5g01820 [T] KOG0583 Serine/threonine protein kinase 100 1e-20
At4g24400 [T] KOG0583 Serine/threonine protein kinase 100 1e-20
At2g23030 [T] KOG0583 Serine/threonine protein kinase 100 1e-20
At1g67890 [T] KOG0192 Tyrosine kinase specific for activated (GT... 100 1e-20
7296166 [T] KOG0614 cGMP-dependent protein kinase 100 1e-20
Hs16357474_1 [T] KOG0612 Rho-associated coiled-coil containing p... 100 1e-20
YDR477w [T] KOG0583 Serine/threonine protein kinase 100 2e-20
SPAC17G8.14c [T] KOG0694 Serine/threonine protein kinase 100 2e-20
At5g63650 [T] KOG0583 Serine/threonine protein kinase 99 2e-20
At5g57630 [T] KOG0583 Serine/threonine protein kinase 99 2e-20
At4g31170 [T] KOG0192 Tyrosine kinase specific for activated (GT... 99 2e-20
At1g78290 [T] KOG0583 Serine/threonine protein kinase 99 2e-20
7292829 [T] KOG0983 Mitogen-activated protein kinase (MAPK) kina... 99 2e-20
YPL150w [T] KOG0583 Serine/threonine protein kinase 99 3e-20
HsM5454184 [T] KOG4721 Serine/threonine protein kinase contains ... 99 3e-20
Hs21735552 [T] KOG4721 Serine/threonine protein kinase contains ... 99 3e-20
CE03979 [T] KOG0614 cGMP-dependent protein kinase 99 3e-20
At5g38210 [T] KOG1187 Serine/threonine protein kinase 99 3e-20
At5g10930 [T] KOG0583 Serine/threonine protein kinase 99 3e-20
At1g62400 [T] KOG0192 Tyrosine kinase specific for activated (GT... 99 3e-20
7303211 [T] KOG4717 Serine/threonine protein kinase 99 3e-20
7301971 [T] KOG0616 cAMP-dependent protein kinase catalytic subu... 99 3e-20
7300435 [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and r... 99 3e-20
Hs7706059 [R] KOG0593 Predicted protein kinase KKIAMRE 99 4e-20
Hs21618349 [T] KOG0984 Mitogen-activated protein kinase (MAPK) k... 99 4e-20
At3g58640 [T] KOG0192 Tyrosine kinase specific for activated (GT... 99 4e-20
At3g18750 [R] KOG0584 Serine/threonine protein kinase 99 4e-20
At1g60940 [T] KOG0583 Serine/threonine protein kinase 99 4e-20
YOR233w [T] KOG0583 Serine/threonine protein kinase 98 5e-20
YJL128c [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K) 98 5e-20
Hs4506739 [RT] KOG0598 Ribosomal protein S6 kinase and related p... 98 5e-20
Hs4502557 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 98 5e-20
CE20167 [T] KOG4236 Serine/threonine protein kinase PKC mu/PKD a... 98 5e-20
At3g50310 [T] KOG0198 MEKK and related serine/threonine protein ... 98 5e-20
At1g30270 [T] KOG0583 Serine/threonine protein kinase 98 5e-20
CE07399 [T] KOG0984 Mitogen-activated protein kinase (MAPK) kina... 98 6e-20
At5g58380 [T] KOG0583 Serine/threonine protein kinase 98 6e-20
At3g04910 [R] KOG0584 Serine/threonine protein kinase 98 6e-20
At2g38490 [T] KOG0583 Serine/threonine protein kinase 98 6e-20
At1g18160 [T] KOG0192 Tyrosine kinase specific for activated (GT... 98 6e-20
7293735 [R] KOG0605 NDR and related serine/threonine kinases 98 6e-20
SPCC16C4.11 [R] KOG0594 Protein kinase PCTAIRE and related kinases 97 8e-20
Hs4758696 [T] KOG4721 Serine/threonine protein kinase contains l... 97 8e-20
CE29318 [T] KOG0660 Mitogen-activated protein kinase 97 8e-20
CE20493 [TR] KOG0606 Microtubule-associated serine/threonine kin... 97 8e-20
CE01146 [T] KOG0585 Ca2+/calmodulin-dependent protein kinase kin... 97 8e-20
At3g21220 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 97 8e-20
At3g06630 [T] KOG0192 Tyrosine kinase specific for activated (GT... 97 8e-20
At1g18390 [T] KOG1187 Serine/threonine protein kinase 97 8e-20
7297009 [R] KOG0593 Predicted protein kinase KKIAMRE 97 8e-20
SPBC409.07c [T] KOG0581 Mitogen-activated protein kinase kinase ... 97 1e-19
SPAC1B9.02c [RT] KOG0598 Ribosomal protein S6 kinase and related... 97 1e-19
ECU07g0360 [D] KOG0580 Serine/threonine protein kinase 97 1e-19
7294217 [D] KOG0588 Serine/threonine protein kinase 97 1e-19
Hs4826684_1 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase... 97 1e-19
CE27894_1 [R] KOG0589 Serine/threonine protein kinase 97 1e-19
SPAC22E12.14c [RT] KOG0598 Ribosomal protein S6 kinase and relat... 97 1e-19
Hs4758192 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 97 1e-19
Hs4557511 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 97 1e-19
Hs20547878 [R] KOG0589 Serine/threonine protein kinase 97 1e-19
Hs20545245 [D] KOG0588 Serine/threonine protein kinase 97 1e-19
CE27166 [T] KOG0616 cAMP-dependent protein kinase catalytic subu... 97 1e-19
CE04603 [T] KOG0616 cAMP-dependent protein kinase catalytic subu... 97 1e-19
At5g11850 [T] KOG0192 Tyrosine kinase specific for activated (GT... 97 1e-19
At3g06640 [T] KOG0192 Tyrosine kinase specific for activated (GT... 97 1e-19
At1g08720 [T] KOG0192 Tyrosine kinase specific for activated (GT... 97 1e-19
7302908 [R] KOG0594 Protein kinase PCTAIRE and related kinases 97 1e-19
CE26793_1 [R] KOG0611 Predicted serine/threonine protein kinase 97 1e-19
SPBC32H8.10 [D] KOG0600 Cdc2-related protein kinase 96 2e-19
HsM4885147 [T] KOG0201 Serine/threonine protein kinase 96 2e-19
Hs4759052 [T] KOG0603 Ribosomal protein S6 kinase 96 2e-19
Hs4504101 [T] KOG0986 G protein-coupled receptor kinase 96 2e-19
CE15612 [T] KOG0690 Serine/threonine protein kinase 96 2e-19
At2g24360 [T] KOG0192 Tyrosine kinase specific for activated (GT... 96 2e-19
At1g48490 [TR] KOG0606 Microtubule-associated serine/threonine k... 96 2e-19
Hs5579478 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 96 2e-19
Hs22035598 [T] KOG0201 Serine/threonine protein kinase 96 2e-19
Hs15277312 [R] KOG0584 Serine/threonine protein kinase 96 2e-19
CE05507 [T] KOG0603 Ribosomal protein S6 kinase 96 2e-19
At3g50500 [T] KOG0583 Serine/threonine protein kinase 96 2e-19
7303019 [Z] KOG0613 Projectin/twitchin and related proteins 96 2e-19
YPL141c [T] KOG0583 Serine/threonine protein kinase 96 3e-19
Hs4885583 [T] KOG0612 Rho-associated coiled-coil containing prot... 96 3e-19
Hs14589902 [T] KOG0984 Mitogen-activated protein kinase (MAPK) k... 96 3e-19
Hs14042947 [T] KOG0583 Serine/threonine protein kinase 96 3e-19
CE29453 [T] KOG0192 Tyrosine kinase specific for activated (GTP-... 96 3e-19
At3g23000 [T] KOG0583 Serine/threonine protein kinase 96 3e-19
At3g20410 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 96 3e-19
Hs21618351 [T] KOG0984 Mitogen-activated protein kinase (MAPK) k... 95 4e-19
Hs14589904 [T] KOG0604 MAP kinase-activated protein kinase 2 95 4e-19
Hs14589900 [T] KOG0984 Mitogen-activated protein kinase (MAPK) k... 95 4e-19
Hs10863901 [T] KOG0604 MAP kinase-activated protein kinase 2 95 4e-19
CE01554 [T] KOG0986 G protein-coupled receptor kinase 95 4e-19
At1g66880 [T] KOG1187 Serine/threonine protein kinase 95 4e-19
At1g01140 [T] KOG0583 Serine/threonine protein kinase 95 4e-19
7300650 [R] KOG0594 Protein kinase PCTAIRE and related kinases 95 4e-19
CE02602_1 [T] KOG0660 Mitogen-activated protein kinase 95 4e-19
SPCC4G3.08 [RT] KOG0598 Ribosomal protein S6 kinase and related ... 95 5e-19
Hs16936528 [R] KOG0594 Protein kinase PCTAIRE and related kinases 95 5e-19
Hs16507245 [T] KOG0583 Serine/threonine protein kinase 95 5e-19
CE19898 [T] KOG0614 cGMP-dependent protein kinase 95 5e-19
CE19897 [T] KOG0614 cGMP-dependent protein kinase 95 5e-19
CE00847 [T] KOG0583 Serine/threonine protein kinase 95 5e-19
7297776 [D] KOG0580 Serine/threonine protein kinase 95 5e-19
7296450 [D] KOG0575 Polo-like serine/threonine protein kinase 95 5e-19
7294414 [T] KOG0200 Fibroblast/platelet-derived growth factor re... 95 5e-19
CE18058_1 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 95 5e-19
YOL016c [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-... 94 7e-19
SPCC1259.13 [D] KOG0590 Checkpoint kinase and related serine/thr... 94 7e-19
Hs4505831 [T] KOG0612 Rho-associated coiled-coil containing prot... 94 7e-19
Hs14754789 [OUT] KOG0595 Serine/threonine-protein kinase involve... 94 7e-19
Hs14110390 [D] KOG0600 Cdc2-related protein kinase 94 7e-19
Hs14110387 [D] KOG0600 Cdc2-related protein kinase 94 7e-19
At5g58950 [T] KOG0192 Tyrosine kinase specific for activated (GT... 94 7e-19
At3g45240 [T] KOG0585 Ca2+/calmodulin-dependent protein kinase k... 94 7e-19
At1g48260 [T] KOG0583 Serine/threonine protein kinase 94 7e-19
7300413 [T] KOG0583 Serine/threonine protein kinase 94 7e-19
7299057 [T] KOG1006 Mitogen-activated protein kinase (MAPK) kina... 94 7e-19
7297611 [T] KOG0614 cGMP-dependent protein kinase 94 7e-19
Hs4759044 [T] KOG0612 Rho-associated coiled-coil containing prot... 94 9e-19
Hs20543401 [TR] KOG0606 Microtubule-associated serine/threonine ... 94 9e-19
Hs20536595 [T] KOG0612 Rho-associated coiled-coil containing pro... 94 9e-19
Hs13186251 [T] KOG0200 Fibroblast/platelet-derived growth factor... 94 9e-19
Hs13186236 [T] KOG0200 Fibroblast/platelet-derived growth factor... 94 9e-19
Hs13186234 [T] KOG0200 Fibroblast/platelet-derived growth factor... 94 9e-19
Hs11276087 [T] KOG0200 Fibroblast/platelet-derived growth factor... 94 9e-19
>YNL298w [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 842
Score = 833 bits (2153), Expect = 0.0
Identities = 478/898 (53%), Positives = 561/898 (62%), Gaps = 77/898 (8%)
Query: 1 MSLSAAARDYSDADFQNIGPAPKPPMG-------FNQTQPISNDFNKLDLNRNLKQRSLV 53
MSLSAAA SD DFQNIGPAP+PP +NQTQPI+ ++LDL L
Sbjct: 1 MSLSAAANKISDNDFQNIGPAPRPPSSNSQGRTCYNQTQPITKLMSQLDLT---SASHLG 57
Query: 54 STTQKRKSGWISYKDDGILSFIWQKRYMVLSDAYLSLYKTEQTIRETPVMQIPLTSIVSV 113
++T K+KSGW+SYKDDGILSFIWQKRY++L D+Y++LYK ++ + +++IPLTSI+SV
Sbjct: 58 TSTSKKKSGWVSYKDDGILSFIWQKRYLMLHDSYVALYKNDKQ-NDDAILKIPLTSIISV 116
Query: 114 SRNQLKQNCFEIIRSSSANG-----SMPMSASQDG-SKKSIYISTKTELELHTWLDAIFA 167
SR QLKQ CFE++R S N S ++ S D SKKSIYI+TKTE +LH+WLDAIFA
Sbjct: 117 SRTQLKQYCFELVRCSDRNSVSSGSSSSLNVSSDSNSKKSIYIATKTESDLHSWLDAIFA 176
Query: 168 RCPLLSGVSSPTNFTHRVHVGFDPETGSFVGMPSNWEKLLKHSRITGEDWNNNSAAVIQV 227
+CPLLSGVSSPTNFTH+VHVGFDPETGSFVGMP+NWEKLLKHSRITGEDWNNNSAAVI
Sbjct: 177 KCPLLSGVSSPTNFTHKVHVGFDPETGSFVGMPTNWEKLLKHSRITGEDWNNNSAAVI-- 234
Query: 228 LQFYQEYNGVNQXXXXXXXXXXXXXXXXXXXXXXXIAKNNFHATLQXXXXXXXXXXXXXX 287
Q Q Y N N TL
Sbjct: 235 -QVLQFYQEYN-------------------------GAGNPTNTLDKPQSGETSSSQKSL 268
Query: 288 XXXXXXXXXXXXXVDAARSDHGKNELIPQRKXXXXXXXXXXNVHPNVEISKASPNNHGPK 347
V++ S + ++ QRK N V + S K
Sbjct: 269 PNSYNDNKLRNNSVNSKSSSGVSSSMVSQRKTSQPP-----NTKSPVSLGSGSLPPINTK 323
Query: 348 VAQQYVPSPQHTQRKPLASLHNMANPYSRTKAGPTVRXXXXXXXXXXXXXXXXXXXXXXX 407
+ P+H Q P M N +S T G R
Sbjct: 324 LPTSQSNIPRHLQNVPNQQYPKMRNGHSPTN-GQFPRGPMHPNNSQRSLQQQQQQQQQQK 382
Query: 408 XXXXXXXXXXXTPAKYPTDGPN-VSPRDQNHKPPSPQNHXXXXXXXXXXXXXXXXXXXXX 466
P+ P+ P+ ++P +H +P +
Sbjct: 383 QQHQQYPYHHQGPSPSPSPSPSPLNPYRPHHNMINPYSKQPQSPLSSQSTQNQAIPRYAQ 442
Query: 467 XTVAIPPRMHPQRIASDRSQNQPKPGMQPLIQVTTSQNKQPSPSQSAAQMAMRQHNQHPA 526
+ PQR A PKP + S + P PS A H Q A
Sbjct: 443 NSSPTAAHFQPQRTA-------PKPPI--------SAPRAPYPSNQNA--TSNTHVQPVA 485
Query: 527 GMPKVANAKLQPAREAPRVGDSNQQKTTEVSK-KKPSKPAMSNAEIMTNLKNVTFNMDPT 585
PK + Q R+AP+ D++ + V+K KKP++P MS AEIM+ LK VT N DP+
Sbjct: 486 --PKNDQSTPQTMRQAPKRPDADVAQPGGVAKPKKPARPTMSTAEIMSKLKKVTVNADPS 543
Query: 586 PFFRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQL-----GNKVAIKQMILSKQPR 640
F+++EKAGQGASGSVYLAER +P + +E N + G+KVAIKQM+LSKQPR
Sbjct: 544 QCFKVIEKAGQGASGSVYLAERTHIPTESNMIELINNDIDEPHVGDKVAIKQMVLSKQPR 603
Query: 641 KELIVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQS 700
KELIVNEILVMKDS+H NIVNFLEAYL+T+DDLWVVME+MEGGSLTDIIENSPT + S
Sbjct: 604 KELIVNEILVMKDSRHKNIVNFLEAYLRTDDDLWVVMEFMEGGSLTDIIENSPTNDNSHS 663
Query: 701 PLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRS 760
PLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTR RVKITDFGFCA+LTDKRS
Sbjct: 664 PLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRARVKITDFGFCARLTDKRS 723
Query: 761 KRATMVGTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATN 820
KRATMVGTPYWMAPEVVKQREYDEK+DVWSLGIMTIEMLE EPPYLNE+PLKALYLIATN
Sbjct: 724 KRATMVGTPYWMAPEVVKQREYDEKIDVWSLGIMTIEMLEGEPPYLNEDPLKALYLIATN 783
Query: 821 GTPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSFFNMSCESQDLISLLEWK 878
GTPKLKHPE LSLEIKRFLSVCLCVDV+YRASTEELLHH FFNM+C+ +DL SLLEWK
Sbjct: 784 GTPKLKHPESLSLEIKRFLSVCLCVDVRYRASTEELLHHGFFNMACDPKDLTSLLEWK 841
>YOL113w [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 655
Score = 400 bits (1028), Expect = e-111
Identities = 208/386 (53%), Positives = 278/386 (71%), Gaps = 20/386 (5%)
Query: 502 SQNKQ-PSPSQSAAQMAMRQHNQHPAGMPKVANAKLQPAREAPRVGDS----NQQKTTEV 556
SQ KQ Q Q +R+H+ + P +L P+ A + DS +++ E+
Sbjct: 279 SQTKQLGKKEQKVIQSHLRRHDNNSTFRPH----RLAPSAPATKNHDSKTKWHKEDLLEL 334
Query: 557 SKKKPSKPAMSNAEIMTNLKNVTFNMDPTPFFRMVEKAGQGASGSVYLAERLQLPPYKDE 616
S EI+ +K V +++P P+F++VEKAGQGASG+VYL++R++LP D
Sbjct: 335 KNNDDSN------EIIMKMKTVAIDVNPRPYFQLVEKAGQGASGAVYLSKRIKLPQENDP 388
Query: 617 LEAEKN---QLGNKVAIKQMILSKQPRKELIVNEILVMKDSKHNNIVNFLEAYLKTEDDL 673
+ + +G +VAIKQ+ LS+QP+K+LI+NE+LVM DS+ NIVNFLEAY+ +++L
Sbjct: 389 RFLKSHCHRVVGERVAIKQIRLSEQPKKQLIMNELLVMNDSRQENIVNFLEAYIIDDEEL 448
Query: 674 WVVMEYMEGGSLTDIIENSPTGSSGQ--SPLTEPQIAYIVRETCQGLKFLHDKHIIHRDI 731
WV+MEYMEGG LTDI++ ++G+ SPL E Q+AYIV+ETCQGLKFLH+K IIHRDI
Sbjct: 449 WVIMEYMEGGCLTDILDAVARSNTGEHSSPLNENQMAYIVKETCQGLKFLHNKKIIHRDI 508
Query: 732 KSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMVGTPYWMAPEVVKQREYDEKVDVWSL 791
KSDN+LL+++G VKITDFGFC +LT+KRSKRATMVGTPYWMAPE+V Q+ YDEKVDVWSL
Sbjct: 509 KSDNILLNSQGLVKITDFGFCVELTEKRSKRATMVGTPYWMAPEIVNQKGYDEKVDVWSL 568
Query: 792 GIMTIEMLESEPPYLNEEPLKALYLIATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYRA 851
GIM IEM+E EPPYLNE+PLKALYLIA NG+PKL+HPE +S + K+FL CL V+V+ RA
Sbjct: 569 GIMLIEMIEGEPPYLNEDPLKALYLIANNGSPKLRHPESVSKQTKQFLDACLQVNVESRA 628
Query: 852 STEELLHHSFFNMSCESQDLISLLEW 877
S +LL F +M+C + L L+W
Sbjct: 629 SVRKLLTFEFLSMACSPEQLKVSLKW 654
Score = 240 bits (613), Expect = 6e-63
Identities = 112/183 (61%), Positives = 148/183 (80%), Gaps = 4/183 (2%)
Query: 59 RKSGWISYKDDGILSFIWQKRYMVLSDAYLSLYKTEQTIRETPVMQIPLTSIVSVSRNQL 118
+K GWISYK DG+ SF+WQKRY+VL+D+YL+ YK+++ E PV+ +PLTSI +VSR QL
Sbjct: 5 KKEGWISYKVDGLFSFLWQKRYLVLNDSYLAFYKSDKC-NEEPVLSVPLTSITNVSRIQL 63
Query: 119 KQNCFEIIRSSSANGSMPMSAS---QDGSKKSIYISTKTELELHTWLDAIFARCPLLSGV 175
KQNCFEI+R++ ++ S + SK+SI+IST+TE +LH WLDAIFA+CPLLSGV
Sbjct: 64 KQNCFEILRATDQKENISPINSYFYESNSKRSIFISTRTERDLHGWLDAIFAKCPLLSGV 123
Query: 176 SSPTNFTHRVHVGFDPETGSFVGMPSNWEKLLKHSRITGEDWNNNSAAVIQVLQFYQEYN 235
SSPTNFTH+VHVGFDP+ G+FVG+P +W KLL+ S IT +DWN NS AVI+ LQFY++YN
Sbjct: 124 SSPTNFTHKVHVGFDPKVGNFVGVPDSWAKLLQTSEITYDDWNRNSKAVIKALQFYEDYN 183
Query: 236 GVN 238
G++
Sbjct: 184 GLD 186
>SPAC1F5.09c [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 589
Score = 334 bits (857), Expect = 3e-91
Identities = 179/330 (54%), Positives = 228/330 (68%), Gaps = 25/330 (7%)
Query: 552 KTTEVSKKKPSKPAMS----NAEIMTNLKNVTFNMDPTPFFRMVEKAGQGASGSVYLAER 607
K T+V K SK +S + + + LK+ + DP +F + K GQGASGSVYLA+
Sbjct: 269 KVTKVPVKADSKNTLSRRMTDRQALAMLKDSVTSHDPVEYFNVKHKLGQGASGSVYLAKV 328
Query: 608 LQLPPYKDELEAEKNQLG--NKVAIKQMILSKQPRKELIVNEILVMKDSKHNNIVNFLEA 665
+ QLG + VAIK + L Q RKELI+NEI VM++S H NIV +L++
Sbjct: 329 VG-----------GKQLGIFDSVAIKSIDLQCQTRKELILNEITVMRESIHPNIVTYLDS 377
Query: 666 YLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAYIVRETCQGLKFLHDKH 725
+L E LWVVMEYM GSLTDIIE +S LTE QIA I ETC+G++ LH ++
Sbjct: 378 FLVRERHLWVVMEYMNAGSLTDIIE--------KSKLTEAQIARICLETCKGIQHLHARN 429
Query: 726 IIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMVGTPYWMAPEVVKQREYDEK 785
IIHRDIKSDNVLLD G +KITDFGFCA+L+++ +KR TMVGTPYWMAPEVVKQ EY K
Sbjct: 430 IIHRDIKSDNVLLDNSGNIKITDFGFCARLSNRTNKRVTMVGTPYWMAPEVVKQNEYGTK 489
Query: 786 VDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTPKLKHPEYLSLEIKRFLSVCLCV 845
VD+WSLGIM IEM+E+EPPYL E+P++ALYLIA NGTP LK P +S +K FL+ CL +
Sbjct: 490 VDIWSLGIMIIEMIENEPPYLREDPIRALYLIAKNGTPTLKKPNLVSKNLKSFLNSCLTI 549
Query: 846 DVKYRASTEELLHHSFFNMSCESQDLISLL 875
D +RA+ ELL HSF N +C ++DL S++
Sbjct: 550 DTIFRATAAELLTHSFLNQACPTEDLKSII 579
Score = 98.2 bits (243), Expect = 5e-20
Identities = 61/174 (35%), Positives = 96/174 (55%), Gaps = 13/174 (7%)
Query: 60 KSGWISYKDDGILSFIWQKRYMVLSDAYLSLYKTEQTIRETPVMQIPLTSIVSVSRNQLK 119
+SGW+ K+D + W K+++VLS LS+YK ++ E+ + + L I V R++ +
Sbjct: 26 RSGWVMLKEDKMKYLPWTKKWLVLSSNSLSIYKGSKS--ESAQVTLLLKDIQKVERSKSR 83
Query: 120 QNCFEIIRSSSANGSMPMSASQDGSKKSIYISTKTELELHTWLDAIFARCPLLSGVSSPT 179
CF++ R S+ + + A + +S +E + W+D I +R L S VSSP
Sbjct: 84 TFCFKL-RFKSSTKNFEIQACE--------LSVADNMECYEWMDLISSRA-LASKVSSPM 133
Query: 180 NFTHRVHVGFDPETGSFVGMPSNWEKLLKHSRITGEDWNNNSAAVIQVLQFYQE 233
N H+VHVG D E G++VG+P W LL+ S IT ++ AVIQ L FY +
Sbjct: 134 NPKHQVHVGIDNE-GNYVGLPKEWILLLQSSSITKQECMEEPKAVIQALDFYSK 186
>YHL007c [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 939
Score = 332 bits (852), Expect = 1e-90
Identities = 194/447 (43%), Positives = 251/447 (55%), Gaps = 62/447 (13%)
Query: 429 NVSPRDQNHKPPSPQNHXXXXXXXXXXXXXXXXXXXXXXTVAIPPRMHPQRIASDRSQNQ 488
NVSP Q H P +P P R R A+ + + Q
Sbjct: 500 NVSPLKQTHAPTTPNRTS-------------------------PNRSSISRNATLKKEEQ 534
Query: 489 PKPGMQPLIQVTTSQNKQPSPSQSAAQMAMRQHNQHPAGMPKVANAKLQPAREAPRVGDS 548
P P + P T P S + + Q + PA V +PA+ +
Sbjct: 535 PLPPIPP-----TKSKTSPIISTAHTPQQVAQSPKAPA-QETVTTPTSKPAQARSLSKEL 588
Query: 549 NQQKTTEVSKKKPSKPAMSNAEIMTNLKNVTFNMDPTPFFRMVEKAGQGASGSVYLAERL 608
N++K E ++K ++ L + + DP+ + + K GQGASG VY A +
Sbjct: 589 NEKKREERERRKK--------QLYAKLNEICSDGDPSTKYANLVKIGQGASGGVYTAYEI 640
Query: 609 QLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKELIVNEILVMKDSKHNNIVNFLEAYLK 668
VAIKQM L KQP+KELI+NEILVMK SKH NIVNF+++Y+
Sbjct: 641 GT--------------NVSVAIKQMNLEKQPKKELIINEILVMKGSKHPNIVNFIDSYV- 685
Query: 669 TEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIH 728
+ DLWV+MEYMEGGSLTD++ + LTE QI + RET GL+FLH K ++H
Sbjct: 686 LKGDLWVIMEYMEGGSLTDVVTHCI--------LTEGQIGAVCRETLSGLEFLHSKGVLH 737
Query: 729 RDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMVGTPYWMAPEVVKQREYDEKVDV 788
RDIKSDN+LL G +K+TDFGFCA++ + KR TMVGTPYWMAPEVV ++EY KVD+
Sbjct: 738 RDIKSDNILLSMEGDIKLTDFGFCAQINELNLKRTTMVGTPYWMAPEVVSRKEYGPKVDI 797
Query: 789 WSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTPKLKHPEYLSLEIKRFLSVCLCVDVK 848
WSLGIM IEM+E EPPYLNE PL+ALYLIATNGTPKLK PE LS +K+FL CLCV+ +
Sbjct: 798 WSLGIMIIEMIEGEPPYLNETPLRALYLIATNGTPKLKEPENLSSSLKKFLDWCLCVEPE 857
Query: 849 YRASTEELLHHSFFNMSCESQDLISLL 875
RAS ELLH + E+ ++ L
Sbjct: 858 DRASATELLHDEYITEIAEANSSLAPL 884
Score = 59.7 bits (143), Expect = 2e-08
Identities = 26/64 (40%), Positives = 38/64 (58%)
Query: 175 VSSPTNFTHRVHVGFDPETGSFVGMPSNWEKLLKHSRITGEDWNNNSAAVIQVLQFYQEY 234
+S+P N H HVG D +TG + G+P WEKLL S I+ + N AV+ +++FYQ+
Sbjct: 337 ISTPYNAKHIHHVGVDSKTGEYTGLPEEWEKLLTSSGISKREQQQNMQAVMDIVKFYQDV 396
Query: 235 NGVN 238
N
Sbjct: 397 TETN 400
>Hs4505599 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 525
Score = 323 bits (827), Expect = 9e-88
Identities = 173/331 (52%), Positives = 224/331 (67%), Gaps = 22/331 (6%)
Query: 545 VGDSNQQKTTEVSKKKPSKPAMSNAEIMTNLKNVTFNMDPTPFFRMVEKAGQGASGSVYL 604
VGDS+ + K+ KP M++ EIM L+ + DP + EK GQGASG+V+
Sbjct: 206 VGDSHVDGAAKSLDKQKKKPKMTDEEIMEKLRTIVSIGDPKKKYTRYEKIGQGASGTVFT 265
Query: 605 AERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKELIVNEILVMKDSKHNNIVNFLE 664
A + L G +VAIKQ+ L KQP+KELI+NEILVMK+ K+ NIVNFL+
Sbjct: 266 ATDVAL--------------GQEVAIKQINLQKQPKKELIINEILVMKELKNPNIVNFLD 311
Query: 665 AYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAYIVRETCQGLKFLHDK 724
+YL D+L+VVMEY+ GGSLTD++ + + E QIA + RE Q L+FLH
Sbjct: 312 SYL-VGDELFVVMEYLAGGSLTDVVTETAC-------MDEAQIAAVCRECLQALEFLHAN 363
Query: 725 HIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMVGTPYWMAPEVVKQREYDE 784
+IHRDIKSDNVLL G VK+TDFGFCA++T ++SKR+TMVGTPYWMAPEVV ++ Y
Sbjct: 364 QVIHRDIKSDNVLLGMEGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGP 423
Query: 785 KVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTPKLKHPEYLSLEIKRFLSVCLC 844
KVD+WSLGIM IEM+E EPPYLNE PL+ALYLIATNGTP+L++PE LS + FL+ CL
Sbjct: 424 KVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPEKLSPIFRDFLNRCLE 483
Query: 845 VDVKYRASTEELLHHSFFNMSCESQDLISLL 875
+DV+ R S +ELL H F ++ L L+
Sbjct: 484 MDVEKRGSAKELLQHPFLKLAKPLSSLTPLI 514
Score = 64.7 bits (156), Expect = 6e-10
Identities = 31/65 (47%), Positives = 41/65 (62%), Gaps = 1/65 (1%)
Query: 175 VSSPTNFTHRVHVGFDPETGSFVGMPSNWEKLLKHSRITGEDWNNNSAAVIQVLQFYQEY 234
+S P++F H +HVGFD TG F GMP W +LL+ S IT + N AV+ VL+FY +
Sbjct: 74 ISPPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKLEQKKNPQAVLDVLKFY-DS 132
Query: 235 NGVNQ 239
N V Q
Sbjct: 133 NTVKQ 137
>Hs7382496 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 545
Score = 322 bits (826), Expect = 1e-87
Identities = 168/322 (52%), Positives = 223/322 (69%), Gaps = 23/322 (7%)
Query: 554 TEVSKKKPSKPAMSNAEIMTNLKNVTFNMDPTPFFRMVEKAGQGASGSVYLAERLQLPPY 613
T ++K+ KP MS+ EI+ L+++ DP + EK GQGASG+VY A +
Sbjct: 236 TRNTEKQKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVAT--- 292
Query: 614 KDELEAEKNQLGNKVAIKQMILSKQPRKELIVNEILVMKDSKHNNIVNFLEAYLKTEDDL 673
G +VAIKQM L +QP+KELI+NEILVM+++K+ NIVN+L++YL D+L
Sbjct: 293 -----------GQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYL-VGDEL 340
Query: 674 WVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKS 733
WVVMEY+ GGSLTD++ ++ + E QIA + RE Q L+FLH +IHRDIKS
Sbjct: 341 WVVMEYLAGGSLTDVVT--------ETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKS 392
Query: 734 DNVLLDTRGRVKITDFGFCAKLTDKRSKRATMVGTPYWMAPEVVKQREYDEKVDVWSLGI 793
DN+LL G VK+TDFGFCA++T ++SKR+TMVGTPYWMAPEVV ++ Y KVD+WSLGI
Sbjct: 393 DNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGI 452
Query: 794 MTIEMLESEPPYLNEEPLKALYLIATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYRAST 853
M IEM+E EPPYLNE PL+ALYLIATNGTP+L++PE LS + FL+ CL +DV+ R S
Sbjct: 453 MAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLDMDVEKRGSA 512
Query: 854 EELLHHSFFNMSCESQDLISLL 875
+ELL H F ++ L L+
Sbjct: 513 KELLQHQFLKIAKPLSSLTPLI 534
Score = 65.5 bits (158), Expect = 3e-10
Identities = 28/57 (49%), Positives = 37/57 (64%)
Query: 175 VSSPTNFTHRVHVGFDPETGSFVGMPSNWEKLLKHSRITGEDWNNNSAAVIQVLQFY 231
+S P++F H +HVGFD TG F GMP W +LL+ S IT + N AV+ VL+FY
Sbjct: 75 ISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKSEQKKNPQAVLDVLEFY 131
>Hs4505601 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 544
Score = 318 bits (814), Expect = 3e-86
Identities = 172/347 (49%), Positives = 228/347 (65%), Gaps = 27/347 (7%)
Query: 529 PKVANAKLQPAREAPRVGDSNQQKTTEVSKKKPSKPAMSNAEIMTNLKNVTFNMDPTPFF 588
P V N ++ P A S + T+ +KK M++ EI+ L+++ DP +
Sbjct: 213 PAVPNKEVTPP-SAENANSSTLYRNTDRQRKKSK---MTDEEILEKLRSIVSVGDPKKKY 268
Query: 589 RMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKELIVNEI 648
EK GQGASG+VY A + G +VAIKQM L +QP+KELI+NEI
Sbjct: 269 TRFEKIGQGASGTVYTALDIAT--------------GQEVAIKQMNLQQQPKKELIINEI 314
Query: 649 LVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIA 708
LVM+++K+ NIVN+L++YL D+LWVVMEY+ GGSLTD++ ++ + E QIA
Sbjct: 315 LVMRENKNPNIVNYLDSYL-VGDELWVVMEYLAGGSLTDVVT--------ETCMDEGQIA 365
Query: 709 YIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMVGT 768
+ RE Q L FLH +IHRDIKSDN+LL G VK+TDFGFCA++T ++SKR+TMVGT
Sbjct: 366 AVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGT 425
Query: 769 PYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTPKLKHP 828
PYWMAPEVV ++ Y KVD+WSLGIM IEM+E EPPYLNE PL+ALYLIATNGTP+L++P
Sbjct: 426 PYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNP 485
Query: 829 EYLSLEIKRFLSVCLCVDVKYRASTEELLHHSFFNMSCESQDLISLL 875
E LS + FL+ CL +DV R S +ELL H F ++ L L+
Sbjct: 486 ERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSSLTPLI 532
Score = 64.7 bits (156), Expect = 6e-10
Identities = 29/64 (45%), Positives = 39/64 (60%)
Query: 175 VSSPTNFTHRVHVGFDPETGSFVGMPSNWEKLLKHSRITGEDWNNNSAAVIQVLQFYQEY 234
+S P++F H +HVGFD TG F G+P W +LL+ S IT + N AV+ VL+FY
Sbjct: 70 ISLPSDFEHTIHVGFDAVTGEFTGIPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSK 129
Query: 235 NGVN 238
VN
Sbjct: 130 ETVN 133
>7298926 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 704
Score = 311 bits (797), Expect = 3e-84
Identities = 186/412 (45%), Positives = 246/412 (59%), Gaps = 40/412 (9%)
Query: 468 TVAIPPRMHPQRIASDRSQNQPKPGMQPLIQVTTSQNKQPS----PSQSAAQMAMRQHNQ 523
T A P + H R S P M T +NK + P + AQ++
Sbjct: 319 TPATPLQNH--RTPGGISAPAASPMMHNNATTTLDKNKNNANLYTPEPTVAQVS------ 370
Query: 524 HPAGMPKVANAKLQPAREAPRVGDSNQQKTTEVSKKKPSKPAMSNAEIMTNLKNVTFNMD 583
AG P A Q A V + T + KK MS+ EI+ L+ + D
Sbjct: 371 --AGGPSSQVAGNQIAVPQAAVAPAATPNTRAANAKKKK---MSDEEILEKLRTIVSVGD 425
Query: 584 PTPFFRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKEL 643
P + +EK GQGASG+VY A ++ G +VAIKQM LS+QP+KEL
Sbjct: 426 PNRKYTKMEKIGQGASGTVYTAI--------------ESSTGMEVAIKQMNLSQQPKKEL 471
Query: 644 IVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLT 703
I+NEILVM+++KH N+VN+L++YL +E+ LWVVMEY+ GGSLTD++ ++ +
Sbjct: 472 IINEILVMRENKHPNVVNYLDSYLVSEE-LWVVMEYLPGGSLTDVVT--------ETCMD 522
Query: 704 EPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRA 763
E QIA + RE Q L+FLH +IHRDIKSDN+LL G VK+TDFGFCA+++ ++SKR
Sbjct: 523 EGQIAAVCREVLQALEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFCAQISPEQSKRT 582
Query: 764 TMVGTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTP 823
TMVGTPYWMAPEVV +++Y KVD+WSLGIM IEM+E EPPYLNE PLKALYLIATNG P
Sbjct: 583 TMVGTPYWMAPEVVTRKQYGPKVDLWSLGIMAIEMVEGEPPYLNENPLKALYLIATNGKP 642
Query: 824 KLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSFFNMSCESQDLISLL 875
++K + LS + FL CL V+V RAS +LL H F ++ L L+
Sbjct: 643 EIKEKDKLSSAFQDFLDQCLEVEVDRRASALDLLKHPFLKLARPLASLTPLI 694
Score = 64.3 bits (155), Expect = 8e-10
Identities = 28/57 (49%), Positives = 38/57 (66%)
Query: 175 VSSPTNFTHRVHVGFDPETGSFVGMPSNWEKLLKHSRITGEDWNNNSAAVIQVLQFY 231
+S PTNF H VHVGFD TG F GMP W +LL +S I+ ++ N AV+ VL+++
Sbjct: 83 ISYPTNFEHTVHVGFDAVTGEFTGMPEAWARLLMNSNISKQEQKKNPQAVLDVLKWF 139
>SPBC1604.14c [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 658
Score = 307 bits (787), Expect = 4e-83
Identities = 187/467 (40%), Positives = 257/467 (54%), Gaps = 50/467 (10%)
Query: 434 DQNHKPPSPQNHXXXXXXXXXXXXXXXXXXXXXXTVAIPPRMHPQRIASD---RSQNQPK 490
++ KPP P+ T + R++P R A S + P
Sbjct: 211 EEGAKPPFPRESTEKPLLSVSALSSSSHLQPTSATSS-SSRLYPSRPAPTPPASSSSSPL 269
Query: 491 PGMQPLIQVTTSQNKQPSP--SQSAAQMAMRQHNQ---HPAGMPKVANAKLQPAREAP-- 543
Q + T++ ++QPSP S + +R H+ P + ++P P
Sbjct: 270 LSSQTVKTTTSNASRQPSPLVSSKSTDNIIRSHSPVLLTPQTLSTSETKHIRPNNSTPYQ 329
Query: 544 -RVGDSNQQKTTEVSKK--KPSKPAM---------SNAEIMTNLKNVTFNMDPTPFFRMV 591
R S + K +K PS P + +++ ++ L+++ +PT +R
Sbjct: 330 RRAETSTKPKAVATPQKVEAPSAPRLQKRAPRQQSNDSAVLAKLQSICNPKNPTLLYRNF 389
Query: 592 EKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNK--VAIKQMILSKQPRKELIVNEIL 649
K GQGASG VY A Q+G VAIK+M +++QP+KE IVNEIL
Sbjct: 390 VKIGQGASGDVYSAR----------------QVGTNLSVAIKKMNINQQPKKEFIVNEIL 433
Query: 650 VMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAY 709
VMK H NIVNF++ + + +LW+VMEYM GGSLT+++ N+ L+E QIA
Sbjct: 434 VMKSHHHKNIVNFIDTFFY-KSELWMVMEYMRGGSLTEVVTNNT--------LSEGQIAA 484
Query: 710 IVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMVGTP 769
I +ET +GL+ LH+ I+HRDIKSDN+LL +G +K+TDFGFCA++ +KR TMVGTP
Sbjct: 485 ICKETLEGLQHLHENGIVHRDIKSDNILLSLQGDIKLTDFGFCAQIDSNMTKRTTMVGTP 544
Query: 770 YWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTPKLKHPE 829
YWMAPEVV ++EY KVDVWSLGIM IEM+E EPPYLNE PL+ALYLIAT GTPK+ PE
Sbjct: 545 YWMAPEVVTRKEYGFKVDVWSLGIMAIEMVEGEPPYLNENPLRALYLIATIGTPKISRPE 604
Query: 830 YLSLEIKRFLSVCLCVDVKYRASTEELLHHSFFNMSCESQDLISLLE 876
LS FLS L V+ K R S+ ELL H F + LI L++
Sbjct: 605 LLSSVFHDFLSKSLTVNPKQRPSSGELLRHPFLKQAVPVSSLIPLIK 651
Score = 55.5 bits (132), Expect = 4e-07
Identities = 57/226 (25%), Positives = 95/226 (41%), Gaps = 40/226 (17%)
Query: 20 PAPKPPMGFNQTQPISNDFN---KLDLNRNLKQRSLVSTTQKRKSGWISYKDDGILSF-I 75
P K P G+ T +++ + ++ +L++ T K + + +D F +
Sbjct: 8 PRKKAPNGYGITPIVAHKTGEPVRYEVEDDLRKLKPSRTAPKPPAINTNLAEDTFSGFPL 67
Query: 76 WQKRYMVLSDAYLSLYKTEQTIRETPVMQIPLTSIVSVSRNQLKQNCFEIIRSSSAN--- 132
Q R V + S + +IR+ +Q ++ + S K++ FE SS ++
Sbjct: 68 SQSRTTVSRVSLGSRQHSSSSIRK---LQTNVSDVRSYDERNQKKSAFENFVSSMSSFLT 124
Query: 133 --GSMPMSASQDGS---KKSIYISTKTELELHTWLDAIFARCPLLSGVSSPTNFTHRVHV 187
GS P S+ GS +KS IS SP + H HV
Sbjct: 125 GGGSSPTSSYGSGSASPRKSTVIS-------------------------SPFDPKHVTHV 159
Query: 188 GFDPETGSFVGMPSNWEKLLKHSRITGEDWNNNSAAVIQVLQFYQE 233
GF+ +TG F GMP+ W+ LLK S IT + + AV+ + FY +
Sbjct: 160 GFNYDTGEFTGMPTEWQALLKVSGITKSEQVQHPQAVLDAMAFYSQ 205
>CE27670 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 572
Score = 305 bits (780), Expect = 3e-82
Identities = 172/399 (43%), Positives = 243/399 (60%), Gaps = 35/399 (8%)
Query: 472 PPRMHPQRIASDRSQNQPKPGMQPLIQVTTSQNKQPSPSQSAAQMAMRQHNQHPAGM--- 528
P +M+P ++ + K G+ P + ++N+ P A H + PA +
Sbjct: 173 PRKMNPMTTSTSSAGYNSKQGVPPTT-FSVNENRSSMPPSYAPPPV--PHGETPADIVPP 229
Query: 529 ------PKVANAKLQPAREAPRVGDSNQQKTTEVSKKKPSKPAMSNAEIMTNLKNVTFNM 582
+ + +P E ++ D ++ + ++ + +K M++AE++T L+ +
Sbjct: 230 AIPDRPARTLSIYTKPKEEEEKIPDLSKGQFGVQARGQKAKKKMTDAEVLTKLRTIVSIG 289
Query: 583 DPTPFFRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKE 642
+P +R V+K G GASGSVY A + EAE VAIKQM L QP+KE
Sbjct: 290 NPDRKYRKVDKIGSGASGSVYTAIEIST-------EAE-------VAIKQMNLKDQPKKE 335
Query: 643 LIVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPL 702
LI+NEILVM+++KH NIVN+L++YL D+LWVVMEY+ GGSLTD++ + +
Sbjct: 336 LIINEILVMRENKHANIVNYLDSYLVC-DELWVVMEYLAGGSLTDVVT--------ECQM 386
Query: 703 TEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKR 762
+ IA + RE Q L+FLH +H+IHRDIKSDN+LL G VK+TDFGFCA+L+ ++ KR
Sbjct: 387 EDGIIAAVCREVLQALEFLHSRHVIHRDIKSDNILLGMDGSVKLTDFGFCAQLSPEQRKR 446
Query: 763 ATMVGTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGT 822
TMVGTPYWMAPEVV +++Y KVDVWSLGIM IEM+E EPPYLNE PL+A+YLIATNG
Sbjct: 447 TTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMAIEMVEGEPPYLNENPLRAIYLIATNGK 506
Query: 823 PKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSF 861
P + ++L K F+ L V V+ R S +LL H F
Sbjct: 507 PDFPGRDSMTLLFKDFVDSALEVQVENRWSASQLLTHPF 545
Score = 66.6 bits (161), Expect = 2e-10
Identities = 26/59 (44%), Positives = 40/59 (67%)
Query: 175 VSSPTNFTHRVHVGFDPETGSFVGMPSNWEKLLKHSRITGEDWNNNSAAVIQVLQFYQE 233
+S P+NF H +HVG+DP+TG F GMP W +LL S+I+ ++ N AV+ L++Y +
Sbjct: 67 ISRPSNFEHTIHVGYDPKTGEFTGMPEAWARLLTDSQISKQEQQQNPQAVLDALKYYTQ 125
>7300149 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 569
Score = 291 bits (745), Expect = 3e-78
Identities = 171/403 (42%), Positives = 237/403 (58%), Gaps = 39/403 (9%)
Query: 471 IPPRMHPQRIASDRSQNQPKPGMQPLIQVTTSQNKQPSPSQSAAQMAMRQHNQHPAGMPK 530
+PP+ P I PKP ++P +VT Q S + NQH
Sbjct: 191 VPPKKSPHTIP-------PKPQIKPKPRVT-----QKFSRTSDIRRDEDSDNQHKINTDT 238
Query: 531 VANAKLQPAREAPRVGDSNQQKTTEVSKKKPSKPAMSNAEIMTNLKNVTFNMDPTPFFRM 590
+ ++PA A G + T + + K + ++AEI L+ + + DP ++
Sbjct: 239 II---IKPAVGAQDAGADDNPDETILRRSKEKRAQKTDAEIYVELRAICNSDDPRERYKT 295
Query: 591 VEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKELIVNEILV 650
++ G+GASG V++A LQ N+ ++VA+K + + Q K+LI+ EI V
Sbjct: 296 TQEVGKGASGIVFIAADLQ------------NE--SQVAVKTIDMKNQSSKDLILTEIRV 341
Query: 651 MKDSKHNNIVNFLEAYL-KTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAY 709
+KD H N+VNFL+AYL + ED LWVVMEYM+GG LTD++ ++ + E QIA
Sbjct: 342 LKDFNHKNLVNFLDAYLLEPEDQLWVVMEYMDGGPLTDVVT--------ETVMKERQIAC 393
Query: 710 IVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMVGTP 769
+ RET + FLH K IIHRDIKSDNVLL G VK+TDFGFCA + + KR TMVGTP
Sbjct: 394 VCRETLYAISFLHAKGIIHRDIKSDNVLLGMDGSVKVTDFGFCANI-EGDEKRQTMVGTP 452
Query: 770 YWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTPKLKHPE 829
YWMAPEVV +++Y +KVD+WS+GIM IEM+E +PPYL E PL+ALYLIA NG P +K +
Sbjct: 453 YWMAPEVVTRKKYGKKVDIWSIGIMAIEMIEGQPPYLYETPLRALYLIAANGRPDIKSWD 512
Query: 830 YLSLEIKRFLSVCLCVDVKYRASTEELLHHSFFNMSCESQDLI 872
LS ++ FL CL V+V RA+ +ELL H F N E + L+
Sbjct: 513 KLSPNLQDFLDRCLQVEVDRRATADELLSHPFLNDCSEVKALV 555
>CE21615 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 378
Score = 278 bits (712), Expect = 2e-74
Identities = 151/357 (42%), Positives = 213/357 (59%), Gaps = 40/357 (11%)
Query: 531 VANAKLQPAREAPRVGDSNQQKTTEVSKKKPSKPA-------------MSNAEIMTNLKN 577
+ N L+ VGD N TT + +P P +S++E++ L+
Sbjct: 38 IGNELLKENSNDKSVGDKNGNTTTNKTTVEPPPPEEPPVRVRASHREKLSDSEVLNQLRE 97
Query: 578 VTFNMDPTPFFRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNK--VAIKQMIL 635
+ +P + M ++ G GASG+V++A N G+ VA+K+M
Sbjct: 98 IVNPSNPLGKYEMKKQIGVGASGTVFVA----------------NVAGSTDVVAVKRMAF 141
Query: 636 SKQPRKELIVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTG 695
QP+KE+++ EI VMK +H N+VN++E+YL DDLWVVM+Y+EGG+LTD++
Sbjct: 142 KTQPKKEMLLTEIKVMKQYRHPNLVNYIESYLVDADDLWVVMDYLEGGNLTDVVV----- 196
Query: 696 SSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKL 755
++ L E QIA +++E + L FLH I+HRDIKSDNVLL G VK+TD GFCA++
Sbjct: 197 ---KTELDEGQIAAVLQECLKALHFLHRHSIVHRDIKSDNVLLGMNGEVKLTDMGFCAQI 253
Query: 756 TDKRSKRATMVGTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALY 815
SKR T+VGTPYWM+PE++ +++Y+ KVD+WSLGIM +EM++ EPPYL E PLKA+Y
Sbjct: 254 -QPGSKRDTVVGTPYWMSPEILNKKQYNYKVDIWSLGIMALEMIDGEPPYLRETPLKAIY 312
Query: 816 LIATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSFFNMSCESQDLI 872
LIA NG P++K + LS E FL CL VD RA T ELL H F + LI
Sbjct: 313 LIAQNGKPEIKQRDRLSSEFNNFLDKCLVVDPDQRADTTELLAHPFLKKAKPLSSLI 369
>Hs5031975 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 591
Score = 238 bits (607), Expect = 3e-62
Identities = 146/404 (36%), Positives = 225/404 (55%), Gaps = 37/404 (9%)
Query: 476 HPQRIAS----DRSQNQPKPGMQPLIQVTTSQNKQPSPSQSAAQMAMRQHNQHPAGMPKV 531
HP R A D + N P G + Q ++S ++ P+ ++ A + + A P++
Sbjct: 215 HPSRGAQGEPHDVAPNGPSAGGLAIPQSSSSSSRPPTRARGAPSPGVLGPH---ASEPQL 271
Query: 532 ANAKLQPAREAPRVGDSNQQKTTEVSKKKPSKPAMSNAEIMTNLKNVTFNMDPTPFFRMV 591
A PA AP V ++ + ++P + +S+ + L+ V DP +
Sbjct: 272 APPACTPA--APAVPGPPGPRSPQ---REPQR--VSHEQFRAALQLVVDPGDPRSYLDNF 324
Query: 592 EKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKELIVNEILVM 651
K G+G++G V +A G VA+K+M L KQ R+EL+ NE+++M
Sbjct: 325 IKIGEGSTGIVCIAT--------------VRSSGKLVAVKKMDLRKQQRRELLFNEVVIM 370
Query: 652 KDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAYIV 711
+D +H N+V +YL D+LWVVME++EGG+LTDI+ ++ + E QIA +
Sbjct: 371 RDYQHENVVEMYNSYL-VGDELWVVMEFLEGGALTDIVTHTR--------MNEEQIAAVC 421
Query: 712 RETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMVGTPYW 771
Q L LH + +IHRDIKSD++LL GRVK++DFGFCA+++ + +R ++VGTPYW
Sbjct: 422 LAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYW 481
Query: 772 MAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTPKLKHPEYL 831
MAPE++ + Y +VD+WSLGIM IEM++ EPPY NE PLKA+ +I N P+LK+ +
Sbjct: 482 MAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKV 541
Query: 832 SLEIKRFLSVCLCVDVKYRASTEELLHHSFFNMSCESQDLISLL 875
S +K FL L D RA+ ELL H F + ++ L+
Sbjct: 542 SPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLM 585
>Hs14771959 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 719
Score = 234 bits (598), Expect = 3e-61
Identities = 123/319 (38%), Positives = 198/319 (61%), Gaps = 25/319 (7%)
Query: 557 SKKKPSKPAMSNAEIMTNLKNVTFNMDPTPFFRMVEKAGQGASGSVYLAERLQLPPYKDE 616
S ++PS+ +S+ + L+ V DP + K G+G++G V +A
Sbjct: 420 SDQQPSR--VSHEQFRAALQLVVSPGDPREYLANFIKIGEGSTGIVCIAT---------- 467
Query: 617 LEAEKNQLGNKVAIKQMILSKQPRKELIVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVV 676
+ G +VA+K+M L KQ R+EL+ NE+++M+D H+N+V+ +YL D+LWVV
Sbjct: 468 ----EKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYL-VGDELWVV 522
Query: 677 MEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNV 736
ME++EGG+LTDI+ ++ + E QIA + + L +LH++ +IHRDIKSD++
Sbjct: 523 MEFLEGGALTDIVTHTR--------MNEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSI 574
Query: 737 LLDTRGRVKITDFGFCAKLTDKRSKRATMVGTPYWMAPEVVKQREYDEKVDVWSLGIMTI 796
LL + GR+K++DFGFCA+++ + KR ++VGTPYWMAPEV+ + Y +VD+WSLGIM I
Sbjct: 575 LLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVI 634
Query: 797 EMLESEPPYLNEEPLKALYLIATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEEL 856
EM++ EPPY NE PL+A+ I + P++K +S ++ FL + L + RA+ +EL
Sbjct: 635 EMIDGEPPYFNEPPLQAMRRIRDSLPPRVKDLHKVSSVLRGFLDLMLVREPSQRATAQEL 694
Query: 857 LHHSFFNMSCESQDLISLL 875
L H F ++ ++ L+
Sbjct: 695 LGHPFLKLAGPPSCIVPLM 713
>CE20564 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 540
Score = 234 bits (598), Expect = 3e-61
Identities = 138/385 (35%), Positives = 205/385 (52%), Gaps = 36/385 (9%)
Query: 502 SQNKQPSPSQSAAQMAMRQHNQHPAGMPKVANAKLQPAREAPRVGDSNQQKTTEVSKKKP 561
SQ P S A + +R NQ P K ++ + ++ T ++ K P
Sbjct: 154 SQRGYPFNDPSYAPLPLR--NQKPPMSTTFGVEKPHQYQQIITIVAPSRTTTPQLQPKSP 211
Query: 562 SKP-----------AMSNAEIMTNLKNVTFNMDPTPFFRMVEKAGQGASGSVYLAERLQL 610
S P +S+ E LK V DP ++ G+G++G V A ++
Sbjct: 212 STPQAMRQQPKCTEGVSDEEFRNALKFVVDGTDPRSDLTDYKQIGEGSTGVVEAAYKIST 271
Query: 611 PPYKDELEAEKNQLGNKVAIKQMILSKQPRKELIVNEILVMKDSKHNNIVNFLEAYLKTE 670
VA+K+M L KQ R+EL+ NE+ +++ +H NIV F ++L +
Sbjct: 272 KQI--------------VAVKRMNLRKQQRRELLFNEVSILRQYQHPNIVRFFSSHL-VD 316
Query: 671 DDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRD 730
D+LWVVME+MEGGSLTDI+ + +TEPQIA I R+ L FLH + +IHRD
Sbjct: 317 DELWVVMEFMEGGSLTDIVT--------ATRMTEPQIATISRQVLGALDFLHARKVIHRD 368
Query: 731 IKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMVGTPYWMAPEVVKQREYDEKVDVWS 790
IKSD++LL G VK+TDFGFC +L+++ +R ++VGTPYW A EV+ + YD + D+WS
Sbjct: 369 IKSDSILLKRDGTVKLTDFGFCGQLSEEVPRRRSLVGTPYWTAAEVIAREPYDTRADIWS 428
Query: 791 LGIMTIEMLESEPPYLNEEPLKALYLIATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYR 850
GIM IEM+E EPP+ N++P +A+ I + +S+E+ LS C+ DV R
Sbjct: 429 FGIMLIEMVEGEPPFFNDQPFQAMKRIRDEHEARFSRHAKVSVELSELLSHCIVKDVNKR 488
Query: 851 ASTEELLHHSFFNMSCESQDLISLL 875
++LL H FF + S + LL
Sbjct: 489 WPAKDLLRHPFFAKAQHSSSIAPLL 513
>CE05425 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 542
Score = 234 bits (598), Expect = 3e-61
Identities = 138/385 (35%), Positives = 205/385 (52%), Gaps = 36/385 (9%)
Query: 502 SQNKQPSPSQSAAQMAMRQHNQHPAGMPKVANAKLQPAREAPRVGDSNQQKTTEVSKKKP 561
SQ P S A + +R NQ P K ++ + ++ T ++ K P
Sbjct: 156 SQRGYPFNDPSYAPLPLR--NQKPPMSTTFGVEKPHQYQQIITIVAPSRTTTPQLQPKSP 213
Query: 562 SKP-----------AMSNAEIMTNLKNVTFNMDPTPFFRMVEKAGQGASGSVYLAERLQL 610
S P +S+ E LK V DP ++ G+G++G V A ++
Sbjct: 214 STPQAMRQQPKCTEGVSDEEFRNALKFVVDGTDPRSDLTDYKQIGEGSTGVVEAAYKIST 273
Query: 611 PPYKDELEAEKNQLGNKVAIKQMILSKQPRKELIVNEILVMKDSKHNNIVNFLEAYLKTE 670
VA+K+M L KQ R+EL+ NE+ +++ +H NIV F ++L +
Sbjct: 274 KQI--------------VAVKRMNLRKQQRRELLFNEVSILRQYQHPNIVRFFSSHL-VD 318
Query: 671 DDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRD 730
D+LWVVME+MEGGSLTDI+ + +TEPQIA I R+ L FLH + +IHRD
Sbjct: 319 DELWVVMEFMEGGSLTDIVT--------ATRMTEPQIATISRQVLGALDFLHARKVIHRD 370
Query: 731 IKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMVGTPYWMAPEVVKQREYDEKVDVWS 790
IKSD++LL G VK+TDFGFC +L+++ +R ++VGTPYW A EV+ + YD + D+WS
Sbjct: 371 IKSDSILLKRDGTVKLTDFGFCGQLSEEVPRRRSLVGTPYWTAAEVIAREPYDTRADIWS 430
Query: 791 LGIMTIEMLESEPPYLNEEPLKALYLIATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYR 850
GIM IEM+E EPP+ N++P +A+ I + +S+E+ LS C+ DV R
Sbjct: 431 FGIMLIEMVEGEPPFFNDQPFQAMKRIRDEHEARFSRHAKVSVELSELLSHCIVKDVNKR 490
Query: 851 ASTEELLHHSFFNMSCESQDLISLL 875
++LL H FF + S + LL
Sbjct: 491 WPAKDLLRHPFFAKAQHSSSIAPLL 515
>Hs18602554 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 227
Score = 233 bits (594), Expect = 1e-60
Identities = 119/215 (55%), Positives = 158/215 (73%), Gaps = 9/215 (4%)
Query: 651 MKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAYI 710
MK+ K+ NIVNFL++YL D+L+VV+EY+ GSLTD++ ++ + E QIA +
Sbjct: 1 MKELKNPNIVNFLDSYL-VGDELFVVVEYLARGSLTDVVT--------ETCMDEAQIAAV 51
Query: 711 VRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMVGTPY 770
RE+ Q L+FLH +IHRDIKSD+VLL G VK+TDFGFCA++T ++SKR+T+V TPY
Sbjct: 52 CRESLQALEFLHANQVIHRDIKSDSVLLGMEGSVKLTDFGFCAQITPEQSKRSTVVRTPY 111
Query: 771 WMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTPKLKHPEY 830
WMAPEVV ++ Y KV+VWSLGIM EM+E EPPYLNE PL+AL LIATNG P+L++PE
Sbjct: 112 WMAPEVVTRKAYGPKVNVWSLGIMATEMVEGEPPYLNENPLRALCLIATNGIPELQNPET 171
Query: 831 LSLEIKRFLSVCLCVDVKYRASTEELLHHSFFNMS 865
LS + FL+ CL DV+ R S +ELL H F ++
Sbjct: 172 LSPIFRDFLNRCLETDVEKRGSAKELLQHLFLKLA 206
>Hs9910476 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 681
Score = 232 bits (591), Expect = 2e-60
Identities = 144/407 (35%), Positives = 222/407 (54%), Gaps = 41/407 (10%)
Query: 477 PQRIASDRS--QNQPKPGMQPLIQVTTSQNKQPSPS-QSAAQMAMRQHNQHPAGMPKVAN 533
P +A +S +QP PL TTS P S ++A PAG P+ +
Sbjct: 300 PSLVAKAQSLPSDQPVGTFSPL---TTSDTSSPQKSLRTAPATGQLPGRSSPAGSPRTWH 356
Query: 534 AKLQPAR----EAPRVGDSNQQKTTEVSKKKPSKPAMSNAEIMTNLKNVTFNMDPTPFFR 589
A++ + + P V + +++ + L+ V DP
Sbjct: 357 AQISTSNLYLPQDPTVAKG--------ALAGEDTGVVTHEQFKAALRMVVDQGDPRLLLD 408
Query: 590 MVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKELIVNEIL 649
K G+G++G V LA EK+ G +VA+K M L KQ R+EL+ NE++
Sbjct: 409 SYVKIGEGSTGIVCLAR-------------EKHS-GRQVAVKMMDLRKQQRRELLFNEVV 454
Query: 650 VMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAY 709
+M+D +H N+V ++YL E+ LWV+ME+++GG+LTDI+ Q L E QIA
Sbjct: 455 IMRDYQHFNVVEMYKSYLVGEE-LWVLMEFLQGGALTDIVS--------QVRLNEEQIAT 505
Query: 710 IVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMVGTP 769
+ Q L +LH + +IHRDIKSD++LL GRVK++DFGFCA+++ KR ++VGTP
Sbjct: 506 VCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTP 565
Query: 770 YWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTPKLKHPE 829
YWMAPEV+ + Y +VD+WSLGIM IEM++ EPPY ++ P++A+ + + PKLK+
Sbjct: 566 YWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNSH 625
Query: 830 YLSLEIKRFLSVCLCVDVKYRASTEELLHHSFFNMSCESQDLISLLE 876
+S ++ FL L D + RA+ +ELL H F + + L+ L++
Sbjct: 626 KVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQTGLPECLVPLIQ 672
>CE27965 [T] KOG0574 STE20-like serine/threonine kinase MST
Length = 525
Score = 202 bits (514), Expect = 2e-51
Identities = 109/287 (37%), Positives = 167/287 (57%), Gaps = 23/287 (8%)
Query: 575 LKNVTFNMDPTPFFRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMI 634
L + N P F +V K G+G+ GSV+ +A + G+ +AIK++
Sbjct: 50 LDSSALNKPPEEVFDIVGKLGEGSYGSVH--------------KAIHRESGHVLAIKKVP 95
Query: 635 LSKQPRKELIVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPT 694
+ ++ I+ EI +M+ K +V + +Y K DLW+VMEY GS++DI+
Sbjct: 96 VDTDLQE--IIKEISIMQQCKSKYVVKYYGSYFK-HSDLWIVMEYCGAGSISDIMR---- 148
Query: 695 GSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAK 754
+ + PL+E +I+ ++R+T +GL++LHD IHRDIK+ N+LL+T G K+ DFG +
Sbjct: 149 --ARRKPLSEQEISAVLRDTLKGLQYLHDLKKIHRDIKAGNILLNTDGIAKLADFGVAGQ 206
Query: 755 LTDKRSKRATMVGTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKAL 814
LTD +KR T++GTP+WMAPEV+++ YD K D+WSLGI IEM E PPY + P++A+
Sbjct: 207 LTDTMAKRNTVIGTPFWMAPEVIEEIGYDTKADIWSLGITAIEMAEGRPPYSDIHPMRAI 266
Query: 815 YLIATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSF 861
++I T P K PE S E F+ CL + R + L H+F
Sbjct: 267 FMIPTKPPPTFKKPEEWSSEFNDFIRSCLIKKPEERKTALRLCEHTF 313
>CE27726 [T] KOG0574 STE20-like serine/threonine kinase MST
Length = 640
Score = 202 bits (514), Expect = 2e-51
Identities = 109/287 (37%), Positives = 167/287 (57%), Gaps = 23/287 (8%)
Query: 575 LKNVTFNMDPTPFFRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMI 634
L + N P F +V K G+G+ GSV+ +A + G+ +AIK++
Sbjct: 22 LDSSALNKPPEEVFDIVGKLGEGSYGSVH--------------KAIHRESGHVLAIKKVP 67
Query: 635 LSKQPRKELIVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPT 694
+ ++ I+ EI +M+ K +V + +Y K DLW+VMEY GS++DI+
Sbjct: 68 VDTDLQE--IIKEISIMQQCKSKYVVKYYGSYFK-HSDLWIVMEYCGAGSISDIMR---- 120
Query: 695 GSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAK 754
+ + PL+E +I+ ++R+T +GL++LHD IHRDIK+ N+LL+T G K+ DFG +
Sbjct: 121 --ARRKPLSEQEISAVLRDTLKGLQYLHDLKKIHRDIKAGNILLNTDGIAKLADFGVAGQ 178
Query: 755 LTDKRSKRATMVGTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKAL 814
LTD +KR T++GTP+WMAPEV+++ YD K D+WSLGI IEM E PPY + P++A+
Sbjct: 179 LTDTMAKRNTVIGTPFWMAPEVIEEIGYDTKADIWSLGITAIEMAEGRPPYSDIHPMRAI 238
Query: 815 YLIATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSF 861
++I T P K PE S E F+ CL + R + L H+F
Sbjct: 239 FMIPTKPPPTFKKPEEWSSEFNDFIRSCLIKKPEERKTALRLCEHTF 285
>CE27082 [T] KOG0574 STE20-like serine/threonine kinase MST
Length = 421
Score = 202 bits (514), Expect = 2e-51
Identities = 109/287 (37%), Positives = 167/287 (57%), Gaps = 23/287 (8%)
Query: 575 LKNVTFNMDPTPFFRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMI 634
L + N P F +V K G+G+ GSV+ +A + G+ +AIK++
Sbjct: 22 LDSSALNKPPEEVFDIVGKLGEGSYGSVH--------------KAIHRESGHVLAIKKVP 67
Query: 635 LSKQPRKELIVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPT 694
+ ++ I+ EI +M+ K +V + +Y K DLW+VMEY GS++DI+
Sbjct: 68 VDTDLQE--IIKEISIMQQCKSKYVVKYYGSYFK-HSDLWIVMEYCGAGSISDIMR---- 120
Query: 695 GSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAK 754
+ + PL+E +I+ ++R+T +GL++LHD IHRDIK+ N+LL+T G K+ DFG +
Sbjct: 121 --ARRKPLSEQEISAVLRDTLKGLQYLHDLKKIHRDIKAGNILLNTDGIAKLADFGVAGQ 178
Query: 755 LTDKRSKRATMVGTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKAL 814
LTD +KR T++GTP+WMAPEV+++ YD K D+WSLGI IEM E PPY + P++A+
Sbjct: 179 LTDTMAKRNTVIGTPFWMAPEVIEEIGYDTKADIWSLGITAIEMAEGRPPYSDIHPMRAI 238
Query: 815 YLIATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSF 861
++I T P K PE S E F+ CL + R + L H+F
Sbjct: 239 FMIPTKPPPTFKKPEEWSSEFNDFIRSCLIKKPEERKTALRLCEHTF 285
>CE07064 [T] KOG0574 STE20-like serine/threonine kinase MST
Length = 523
Score = 202 bits (514), Expect = 2e-51
Identities = 109/287 (37%), Positives = 167/287 (57%), Gaps = 23/287 (8%)
Query: 575 LKNVTFNMDPTPFFRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMI 634
L + N P F +V K G+G+ GSV+ +A + G+ +AIK++
Sbjct: 50 LDSSALNKPPEEVFDIVGKLGEGSYGSVH--------------KAIHRESGHVLAIKKVP 95
Query: 635 LSKQPRKELIVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPT 694
+ ++ I+ EI +M+ K +V + +Y K DLW+VMEY GS++DI+
Sbjct: 96 VDTDLQE--IIKEISIMQQCKSKYVVKYYGSYFK-HSDLWIVMEYCGAGSISDIMR---- 148
Query: 695 GSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAK 754
+ + PL+E +I+ ++R+T +GL++LHD IHRDIK+ N+LL+T G K+ DFG +
Sbjct: 149 --ARRKPLSEQEISAVLRDTLKGLQYLHDLKKIHRDIKAGNILLNTDGIAKLADFGVAGQ 206
Query: 755 LTDKRSKRATMVGTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKAL 814
LTD +KR T++GTP+WMAPEV+++ YD K D+WSLGI IEM E PPY + P++A+
Sbjct: 207 LTDTMAKRNTVIGTPFWMAPEVIEEIGYDTKADIWSLGITAIEMAEGRPPYSDIHPMRAI 266
Query: 815 YLIATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSF 861
++I T P K PE S E F+ CL + R + L H+F
Sbjct: 267 FMIPTKPPPTFKKPEEWSSEFNDFIRSCLIKKPEERKTALRLCEHTF 313
>At1g69220 [T] KOG0576 Mitogen-activated protein kinase kinase kinase kinase
(MAP4K) germinal center kinase family
Length = 836
Score = 200 bits (508), Expect = 9e-51
Identities = 117/328 (35%), Positives = 180/328 (54%), Gaps = 32/328 (9%)
Query: 535 KLQPAREAPRVGDSNQQKTTEVSKKKPSKPAMSNAEIMTNLKNVTFNMDPTPFFRMVEKA 594
KL P+ + ++ + +K + + K + T+L + DPT + + +
Sbjct: 206 KLDPSSSSSKLHGEDNRKMQQQNSKMST----------TSLPDSITREDPTTKYEFLNEL 255
Query: 595 GQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSK-QPRKELIVNEILVMKD 653
G+G+ GSVY A L+ VA+K + L++ + E I EI +++
Sbjct: 256 GKGSYGSVYKARDLKTSEI--------------VAVKVISLTEGEEGYEEIRGEIEMLQQ 301
Query: 654 SKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAYIVRE 713
H N+V +L +Y + ED LW+VMEY GGS+ D++ + + L E QIAYI RE
Sbjct: 302 CNHPNVVRYLGSY-QGEDYLWIVMEYCGGGSVADLMNVT------EEALEEYQIAYICRE 354
Query: 714 TCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMVGTPYWMA 773
+GL +LH + +HRDIK N+LL +G VK+ DFG A+LT SKR T +GTP+WMA
Sbjct: 355 ALKGLAYLHSIYKVHRDIKGGNILLTEQGEVKLGDFGVAAQLTRTMSKRNTFIGTPHWMA 414
Query: 774 PEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTPKLKHPEYLSL 833
PEV+++ YD KVDVW+LG+ IEM E PP + P++ L++I+ P L+ E SL
Sbjct: 415 PEVIQENRYDGKVDVWALGVSAIEMAEGLPPRSSVHPMRVLFMISIEPAPMLEDKEKWSL 474
Query: 834 EIKRFLSVCLCVDVKYRASTEELLHHSF 861
F++ CL + + R + E+L H F
Sbjct: 475 VFHDFVAKCLTKEPRLRPTAAEMLKHKF 502
>Hs5454096 [T] KOG0574 STE20-like serine/threonine kinase MST
Length = 487
Score = 199 bits (506), Expect = 2e-50
Identities = 110/290 (37%), Positives = 164/290 (55%), Gaps = 23/290 (7%)
Query: 572 MTNLKNVTFNMDPTPFFRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIK 631
+ L + P F ++EK G+G+ GSVY +A + G VAIK
Sbjct: 14 LKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVY--------------KAIHKETGQIVAIK 59
Query: 632 QMILSKQPRKELIVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIEN 691
Q+ + ++ I+ EI +M+ ++V + +Y K D LW+VMEY GS++DII
Sbjct: 60 QVPVESDLQE--IIKEISIMQQCDSPHVVKYYGSYFKNTD-LWIVMEYCGAGSVSDIIRL 116
Query: 692 SPTGSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGF 751
LTE +IA I++ T +GL++LH IHRDIK+ N+LL+T G K+ DFG
Sbjct: 117 R------NKTLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGV 170
Query: 752 CAKLTDKRSKRATMVGTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPL 811
+LTD +KR T++GTP+WMAPEV+++ Y+ D+WSLGI IEM E +PPY + P+
Sbjct: 171 AGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPM 230
Query: 812 KALYLIATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSF 861
+A+++I TN P + PE S F+ CL + RA+ +LL H F
Sbjct: 231 RAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPF 280
>7291778 [T] KOG0579 Ste20-like serine/threonine protein kinase
Length = 1726
Score = 199 bits (506), Expect = 2e-50
Identities = 115/308 (37%), Positives = 164/308 (52%), Gaps = 34/308 (11%)
Query: 577 NVTFNMDPTPFFRMVEKAGQGASGSVYLAERLQLPPYKD----ELEAEKNQLGNKVAIKQ 632
N+ + DP F+ MV + G GA G VY A+ + + +LE E+N + V
Sbjct: 26 NIKMDTDPAEFWEMVGELGDGAFGKVYKAQHKEQKRFAAAKMCQLEDEENLSDHMV---- 81
Query: 633 MILSKQPRKELIVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENS 692
EI ++ + KH NIV EA+ +D LW+++EY +GG+L I+
Sbjct: 82 --------------EIDILSEIKHPNIVELYEAF-SIDDKLWMLIEYCDGGALDSIMVEL 126
Query: 693 PTGSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFC 752
+ PLTEPQIAY+ + +GL FLH +IHRD+K+ NVLL G VK+ DFG
Sbjct: 127 ------EKPLTEPQIAYVCKHMTEGLTFLHRNKVIHRDLKAGNVLLTMEGGVKLADFGVS 180
Query: 753 AKLTDKRSKRATMVGTPYWMAPEVV-----KQREYDEKVDVWSLGIMTIEMLESEPPYLN 807
AK K T +GTPYWMAPE+V + YD KVD+WSLGI IE+ + EPP
Sbjct: 181 AKNKHTMQKHDTFIGTPYWMAPELVLCETFRDNPYDHKVDIWSLGITLIELAQMEPPNSE 240
Query: 808 EEPLKALYLIATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSFFNMSCE 867
P++ L I + PKL+ P S E FL L D + R +T+ L+ H+F N + +
Sbjct: 241 MSPMRVLLKIQKSEPPKLEQPSRWSKEFNDFLKKSLVKDPQVRPTTDVLMQHAFINRNLD 300
Query: 868 SQDLISLL 875
++ + LL
Sbjct: 301 AKPIKDLL 308
>Hs20070158 [T] KOG0201 Serine/threonine protein kinase
Length = 443
Score = 197 bits (500), Expect = 8e-50
Identities = 117/290 (40%), Positives = 158/290 (54%), Gaps = 31/290 (10%)
Query: 573 TNLKNVTFNMDPTPFFRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQ 632
TNLK DP F +EK G+G+ G V+ + N+ VAIK
Sbjct: 26 TNLK-----ADPEELFTKLEKIGKGSFGEVF--------------KGIDNRTQKVVAIKI 66
Query: 633 MILSK-QPRKELIVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIEN 691
+ L + + E I EI V+ + + +YLK + LW++MEY+ GGS D++E
Sbjct: 67 IDLEEAEDEIEDIQQEITVLSQCDSPYVTKYYGSYLK-DTKLWIIMEYLGGGSALDLLE- 124
Query: 692 SPTGSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGF 751
PL E QIA I+RE +GL +LH + IHRDIK+ NVLL G VK+ DFG
Sbjct: 125 -------PGPLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGV 177
Query: 752 CAKLTDKRSKRATMVGTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPL 811
+LTD + KR T VGTP+WMAPEV+KQ YD K D+WSLGI IE+ EPP+ P+
Sbjct: 178 AGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSELHPM 237
Query: 812 KALYLIATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSF 861
K L+LI N P L+ S +K F+ CL + +R + +ELL H F
Sbjct: 238 KVLFLIPKNNPPTLE--GNYSKPLKEFVEACLNKEPSFRPTAKELLKHKF 285
>Hs5454094 [T] KOG0574 STE20-like serine/threonine kinase MST
Length = 491
Score = 196 bits (499), Expect = 1e-49
Identities = 108/290 (37%), Positives = 165/290 (56%), Gaps = 23/290 (7%)
Query: 572 MTNLKNVTFNMDPTPFFRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIK 631
+ L + P F ++EK G+G+ GSV+ +A + G VAIK
Sbjct: 11 LKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVF--------------KAIHKESGQVVAIK 56
Query: 632 QMILSKQPRKELIVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIEN 691
Q+ + ++ I+ EI +M+ +V + +Y K D LW+VMEY GS++DII
Sbjct: 57 QVPVESDLQE--IIKEISIMQQCDSPYVVKYYGSYFKNTD-LWIVMEYCGAGSVSDIIRL 113
Query: 692 SPTGSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGF 751
L E +IA I++ T +GL++LH IHRDIK+ N+LL+T G K+ DFG
Sbjct: 114 R------NKTLIEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGV 167
Query: 752 CAKLTDKRSKRATMVGTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPL 811
+LTD +KR T++GTP+WMAPEV+++ Y+ D+WSLGI +IEM E +PPY + P+
Sbjct: 168 AGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPM 227
Query: 812 KALYLIATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSF 861
+A+++I TN P + PE S + F+ CL + + RA+ +LL H F
Sbjct: 228 RAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPF 277
>Hs16178962 [T] KOG0574 STE20-like serine/threonine kinase MST
Length = 491
Score = 196 bits (499), Expect = 1e-49
Identities = 108/290 (37%), Positives = 165/290 (56%), Gaps = 23/290 (7%)
Query: 572 MTNLKNVTFNMDPTPFFRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIK 631
+ L + P F ++EK G+G+ GSV+ +A + G VAIK
Sbjct: 11 LKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVF--------------KAIHKESGQVVAIK 56
Query: 632 QMILSKQPRKELIVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIEN 691
Q+ + ++ I+ EI +M+ +V + +Y K D LW+VMEY GS++DII
Sbjct: 57 QVPVESDLQE--IIKEISIMQQCDSPYVVKYYGSYFKNTD-LWIVMEYCGAGSVSDIIRL 113
Query: 692 SPTGSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGF 751
L E +IA I++ T +GL++LH IHRDIK+ N+LL+T G K+ DFG
Sbjct: 114 R------NKTLIEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGV 167
Query: 752 CAKLTDKRSKRATMVGTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPL 811
+LTD +KR T++GTP+WMAPEV+++ Y+ D+WSLGI +IEM E +PPY + P+
Sbjct: 168 AGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPM 227
Query: 812 KALYLIATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSF 861
+A+++I TN P + PE S + F+ CL + + RA+ +LL H F
Sbjct: 228 RAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPF 277
>7292249 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 979
Score = 192 bits (489), Expect = 1e-48
Identities = 113/295 (38%), Positives = 159/295 (53%), Gaps = 30/295 (10%)
Query: 577 NVTFNMDPTPFFRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILS 636
++T DP F ++E G G G VY + + G AIK M ++
Sbjct: 21 DLTALKDPAGIFELIEVVGNGTYGQVY--------------KGRHTKTGQLAAIKVMDVT 66
Query: 637 KQPRKELIVNEILVMKDSKHNNIVNFLEAYLKT-----EDDLWVVMEYMEGGSLTDIIEN 691
+ +E+ + ++ K S H NI + A++K +D LW+VMEY GS+TD++++
Sbjct: 67 EDEEEEIKLEINVLKKYSNHRNIATYYGAFIKKSPPGKDDQLWLVMEYCGAGSVTDLVKS 126
Query: 692 SPTGSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGF 751
+ GQS L E IAYI RE +GL +LH +IHRDIK NVLL VK+ DFG
Sbjct: 127 T----KGQS-LKEEWIAYICREILRGLSYLHSNKVIHRDIKGQNVLLTDNAEVKLVDFGV 181
Query: 752 CAKLTDKRSKRATMVGTPYWMAPEVVKQRE-----YDEKVDVWSLGIMTIEMLESEPPYL 806
A+L +R T +GTPYWMAPEV+ E YD + D+WSLGI +EM ES+PP
Sbjct: 182 SAQLDRTIGRRNTFIGTPYWMAPEVIACDENPDATYDNRSDLWSLGITALEMAESQPPLC 241
Query: 807 NEEPLKALYLIATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSF 861
+ P++AL+LI N P+LK ++ S + F+ L D R TE LL H F
Sbjct: 242 DLHPMRALFLIPRNSPPRLKSKKW-SKKFHGFIDTVLVKDYHQRPYTENLLKHGF 295
>CE28674 [T] KOG0201 Serine/threonine protein kinase
Length = 651
Score = 192 bits (487), Expect = 2e-48
Identities = 117/323 (36%), Positives = 171/323 (52%), Gaps = 30/323 (9%)
Query: 555 EVSKKKPSKPAMSNAEIMTNLKNVTFNMDPTPFFRMVEKAGQGASGSVYLAERLQLPPYK 614
EVS KP++ I N K +DP F E+ G+G+ G VY
Sbjct: 4 EVSPPKPAERRKVVKPIEDNSK-----LDPEVIFTKQERIGRGSFGEVY----------- 47
Query: 615 DELEAEKNQLGNKVAIKQMILSK-QPRKELIVNEILVMKDSKHNNIVNFLEAYLKTEDDL 673
+ N+ G VAIK + L + + E I EI V+ + + ++LK L
Sbjct: 48 ---KGIDNRTGRVVAIKIIDLEQAEDEIEDIQQEIQVLSQCDSQYVTKYFGSFLKGSK-L 103
Query: 674 WVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKS 733
W++MEY+ GGS D+ ++ L E IA I+RE +GL++LH + IHRDIK+
Sbjct: 104 WIIMEYLGGGSALDLTKSGK--------LDESHIAVILREILKGLEYLHSERKIHRDIKA 155
Query: 734 DNVLLDTRGRVKITDFGFCAKLTDKRSKRATMVGTPYWMAPEVVKQREYDEKVDVWSLGI 793
NVL+ G VK+ DFG +LT+ KR T VG+P+WMAPE++KQ YD K D+WSLGI
Sbjct: 156 ANVLVSEHGDVKVADFGVAGQLTETVKKRITFVGSPFWMAPELIKQSSYDYKADIWSLGI 215
Query: 794 MTIEMLESEPPYLNEEPLKALYLIATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYRAST 853
IE+ EPP+ + P++ L+LI N P L+ ++ S K F+ +CL D + R S
Sbjct: 216 TAIELANGEPPHSDLHPMRVLFLIPKNPPPVLQGSQW-SKPFKEFVEMCLNKDPENRPSA 274
Query: 854 EELLHHSFFNMSCESQDLISLLE 876
LL H F + ++ L+ L+E
Sbjct: 275 STLLKHQFIKRAKKNSILVDLIE 297
>7302458 [T] KOG0574 STE20-like serine/threonine kinase MST
Length = 596
Score = 191 bits (486), Expect = 3e-48
Identities = 114/329 (34%), Positives = 175/329 (52%), Gaps = 23/329 (6%)
Query: 548 SNQQKTTEVSKKKPSKPAMSNAEIMTNLKNVTFNMDPTPFFRMVEKAGQGASGSVYLAER 607
S + T+ V K P+ + + + L + P F ++ K G+G+ GSVY
Sbjct: 2 SEPEVTSVVDMKSPNISSSCSFFKLKKLSEESLLQPPEKVFDIMYKLGEGSYGSVY---- 57
Query: 608 LQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKELIVNEILVMKDSKHNNIVNFLEAYL 667
+A + + VAIK + + + I+ EI +M+ +V + +Y
Sbjct: 58 ----------KAVHKESSSIVAIKLVPVESDLHE--IIKEISIMQQCDSPYVVRYYGSYF 105
Query: 668 KTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAYIVRETCQGLKFLHDKHII 727
K + DLW+ MEY GS++DI+ + LTE +IA I+ +T QGL +LH + I
Sbjct: 106 K-QYDLWICMEYCGAGSVSDIMRLR------KKTLTEDEIATILSDTLQGLVYLHLRRKI 158
Query: 728 HRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMVGTPYWMAPEVVKQREYDEKVD 787
HRDIK+ N+LL+T G K+ DFG +LTD +KR T++GTP+WMAPEV+++ YD D
Sbjct: 159 HRDIKAANILLNTEGYAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIEEIGYDCVAD 218
Query: 788 VWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTPKLKHPEYLSLEIKRFLSVCLCVDV 847
+WSLGI +EM E +PPY P++A+++I P + P+ S E F+S CL +
Sbjct: 219 IWSLGITALEMAEGKPPYGEIHPMRAIFMIPQKPPPSFREPDRWSTEFIDFVSKCLVKEP 278
Query: 848 KYRASTEELLHHSFFNMSCESQDLISLLE 876
RA+ ELL H F + L +LE
Sbjct: 279 DDRATATELLEHEFIRNAKHRSILKPMLE 307
>HsM5454174 [T] KOG0201 Serine/threonine protein kinase
Length = 426
Score = 191 bits (485), Expect = 4e-48
Identities = 114/304 (37%), Positives = 162/304 (52%), Gaps = 31/304 (10%)
Query: 582 MDPTPFFRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSK-QPR 640
+DP F +++ G+G+ G VY + N VAIK + L + +
Sbjct: 14 VDPEELFTKLDRIGKGSFGEVY--------------KGIDNHTKEVVAIKIIDLEEAEDE 59
Query: 641 KELIVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQS 700
E I EI V+ I + +YLK+ LW++MEY+ GGS D+++
Sbjct: 60 IEDIQQEITVLSQCDSPYITRYFGSYLKSTK-LWIIMEYLGGGSALDLLK--------PG 110
Query: 701 PLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRS 760
PL E IA I+RE +GL +LH + IHRDIK+ NVLL +G VK+ DFG +LTD +
Sbjct: 111 PLEETYIATILREILKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQI 170
Query: 761 KRATMVGTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATN 820
KR T VGTP+WMAPEV+KQ YD K D+WSLGI IE+ + EPP + P++ L+LI N
Sbjct: 171 KRNTFVGTPFWMAPEVIKQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKN 230
Query: 821 GTPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSFFNMSCESQDLISLL----- 875
P L+ S K F+ CL D ++R + +ELL H F + ++ L
Sbjct: 231 SPPTLEGQH--SKPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELIDRYK 288
Query: 876 EWKN 879
WK+
Sbjct: 289 RWKS 292
>Hs21361358 [T] KOG0201 Serine/threonine protein kinase
Length = 426
Score = 191 bits (485), Expect = 4e-48
Identities = 114/304 (37%), Positives = 162/304 (52%), Gaps = 31/304 (10%)
Query: 582 MDPTPFFRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSK-QPR 640
+DP F +++ G+G+ G VY + N VAIK + L + +
Sbjct: 14 VDPEELFTKLDRIGKGSFGEVY--------------KGIDNHTKEVVAIKIIDLEEAEDE 59
Query: 641 KELIVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQS 700
E I EI V+ I + +YLK+ LW++MEY+ GGS D+++
Sbjct: 60 IEDIQQEITVLSQCDSPYITRYFGSYLKSTK-LWIIMEYLGGGSALDLLK--------PG 110
Query: 701 PLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRS 760
PL E IA I+RE +GL +LH + IHRDIK+ NVLL +G VK+ DFG +LTD +
Sbjct: 111 PLEETYIATILREILKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQI 170
Query: 761 KRATMVGTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATN 820
KR T VGTP+WMAPEV+KQ YD K D+WSLGI IE+ + EPP + P++ L+LI N
Sbjct: 171 KRNTFVGTPFWMAPEVIKQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKN 230
Query: 821 GTPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSFFNMSCESQDLISLL----- 875
P L+ S K F+ CL D ++R + +ELL H F + ++ L
Sbjct: 231 SPPTLEGQH--SKPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTKKTSFLTELIDRYK 288
Query: 876 EWKN 879
WK+
Sbjct: 289 RWKS 292
>CE07510 [T] KOG0201 Serine/threonine protein kinase
Length = 653
Score = 189 bits (479), Expect = 2e-47
Identities = 109/296 (36%), Positives = 161/296 (53%), Gaps = 25/296 (8%)
Query: 582 MDPTPFFRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSK-QPR 640
+DP F E+ G+G+ G VY + N+ G VAIK + L + +
Sbjct: 28 LDPEVIFTKQERIGRGSFGEVY--------------KGIDNRTGRVVAIKIIDLEQAEDE 73
Query: 641 KELIVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQS 700
E I EI V+ + + ++LK LW++MEY+ GGS D+ ++
Sbjct: 74 IEDIQQEIQVLSQCDSQYVTKYFGSFLKGSK-LWIIMEYLGGGSALDLTKSGK------- 125
Query: 701 PLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRS 760
L E IA I+RE +GL++LH + IHRDIK+ NVL+ G VK+ DFG +LT+
Sbjct: 126 -LDESHIAVILREILKGLEYLHSERKIHRDIKAANVLVSEHGDVKVADFGVAGQLTETVK 184
Query: 761 KRATMVGTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATN 820
KR T VG+P+WMAPE++KQ YD K D+WSLGI IE+ EPP+ + P++ L+LI N
Sbjct: 185 KRITFVGSPFWMAPELIKQSSYDYKADIWSLGITAIELANGEPPHSDLHPMRVLFLIPKN 244
Query: 821 GTPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSFFNMSCESQDLISLLE 876
P L+ ++ S K F+ +CL D + R S LL H F + ++ L+ L+E
Sbjct: 245 PPPVLQGSQW-SKPFKEFVEMCLNKDPENRPSASTLLKHQFIKRAKKNSILVDLIE 299
>HsM4758524 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 1165
Score = 188 bits (478), Expect = 3e-47
Identities = 111/289 (38%), Positives = 154/289 (52%), Gaps = 30/289 (10%)
Query: 583 DPTPFFRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKE 642
DP F +VE G G G VY ++ G AIK M +++ +E
Sbjct: 20 DPAGIFELVEVVGNGTYGQVYKGRHVKT--------------GQLAAIKVMDVTEDEEEE 65
Query: 643 LIVNEILVMKDSKHNNIVNFLEAYLKT-----EDDLWVVMEYMEGGSLTDIIENSPTGSS 697
+ + ++ K S H NI + A++K +D LW+VME+ GS+TD+++N+ +
Sbjct: 66 IKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNT- 124
Query: 698 GQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTD 757
L E IAYI RE +GL LH H+IHRDIK NVLL VK+ DFG A+L
Sbjct: 125 ----LKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 758 KRSKRATMVGTPYWMAPEVVKQRE-----YDEKVDVWSLGIMTIEMLESEPPYLNEEPLK 812
+R T +GTPYWMAPEV+ E YD + D+WS GI IEM E PP + P++
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
Query: 813 ALYLIATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSF 861
AL+LI N P+LK ++ S + F+ CL + R STE+LL H F
Sbjct: 241 ALFLIPRNPPPRLKSKKW-SKKFFSFIEGCLVKNYMQRPSTEQLLKHPF 288
>Hs22035606 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 1212
Score = 188 bits (478), Expect = 3e-47
Identities = 111/289 (38%), Positives = 154/289 (52%), Gaps = 30/289 (10%)
Query: 583 DPTPFFRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKE 642
DP F +VE G G G VY ++ G AIK M +++ +E
Sbjct: 20 DPAGIFELVEVVGNGTYGQVYKGRHVKT--------------GQLAAIKVMDVTEDEEEE 65
Query: 643 LIVNEILVMKDSKHNNIVNFLEAYLKT-----EDDLWVVMEYMEGGSLTDIIENSPTGSS 697
+ + ++ K S H NI + A++K +D LW+VME+ GS+TD+++N+ +
Sbjct: 66 IKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNT- 124
Query: 698 GQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTD 757
L E IAYI RE +GL LH H+IHRDIK NVLL VK+ DFG A+L
Sbjct: 125 ----LKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 758 KRSKRATMVGTPYWMAPEVVKQRE-----YDEKVDVWSLGIMTIEMLESEPPYLNEEPLK 812
+R T +GTPYWMAPEV+ E YD + D+WS GI IEM E PP + P++
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
Query: 813 ALYLIATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSF 861
AL+LI N P+LK ++ S + F+ CL + R STE+LL H F
Sbjct: 241 ALFLIPRNPPPRLKSKKW-SKKFFSFIEGCLVKNYMQRPSTEQLLKHPF 288
>Hs22035604 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 1320
Score = 188 bits (478), Expect = 3e-47
Identities = 111/289 (38%), Positives = 154/289 (52%), Gaps = 30/289 (10%)
Query: 583 DPTPFFRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKE 642
DP F +VE G G G VY ++ G AIK M +++ +E
Sbjct: 20 DPAGIFELVEVVGNGTYGQVYKGRHVKT--------------GQLAAIKVMDVTEDEEEE 65
Query: 643 LIVNEILVMKDSKHNNIVNFLEAYLKT-----EDDLWVVMEYMEGGSLTDIIENSPTGSS 697
+ + ++ K S H NI + A++K +D LW+VME+ GS+TD+++N+ +
Sbjct: 66 IKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNT- 124
Query: 698 GQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTD 757
L E IAYI RE +GL LH H+IHRDIK NVLL VK+ DFG A+L
Sbjct: 125 ----LKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 758 KRSKRATMVGTPYWMAPEVVKQRE-----YDEKVDVWSLGIMTIEMLESEPPYLNEEPLK 812
+R T +GTPYWMAPEV+ E YD + D+WS GI IEM E PP + P++
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
Query: 813 ALYLIATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSF 861
AL+LI N P+LK ++ S + F+ CL + R STE+LL H F
Sbjct: 241 ALFLIPRNPPPRLKSKKW-SKKFFSFIEGCLVKNYMQRPSTEQLLKHPF 288
>Hs22035602 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 1166
Score = 188 bits (478), Expect = 3e-47
Identities = 111/289 (38%), Positives = 154/289 (52%), Gaps = 30/289 (10%)
Query: 583 DPTPFFRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKE 642
DP F +VE G G G VY ++ G AIK M +++ +E
Sbjct: 20 DPAGIFELVEVVGNGTYGQVYKGRHVKT--------------GQLAAIKVMDVTEDEEEE 65
Query: 643 LIVNEILVMKDSKHNNIVNFLEAYLKT-----EDDLWVVMEYMEGGSLTDIIENSPTGSS 697
+ + ++ K S H NI + A++K +D LW+VME+ GS+TD+++N+ +
Sbjct: 66 IKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNT- 124
Query: 698 GQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTD 757
L E IAYI RE +GL LH H+IHRDIK NVLL VK+ DFG A+L
Sbjct: 125 ----LKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 758 KRSKRATMVGTPYWMAPEVVKQRE-----YDEKVDVWSLGIMTIEMLESEPPYLNEEPLK 812
+R T +GTPYWMAPEV+ E YD + D+WS GI IEM E PP + P++
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMR 240
Query: 813 ALYLIATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSF 861
AL+LI N P+LK ++ S + F+ CL + R STE+LL H F
Sbjct: 241 ALFLIPRNPPPRLKSKKW-SKKFFSFIEGCLVKNYMQRPSTEQLLKHPF 288
>7302511 [T] KOG0576 Mitogen-activated protein kinase kinase kinase kinase
(MAP4K) germinal center kinase family
Length = 1218
Score = 188 bits (478), Expect = 3e-47
Identities = 109/290 (37%), Positives = 165/290 (56%), Gaps = 29/290 (10%)
Query: 583 DPTPFFRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKE 642
+P + +++K G G G VY A+R+Q N+L AIK + L +
Sbjct: 21 NPQDEYELIQKIGSGTYGDVYKAKRIQ-----------SNELA---AIKVIKLEPSDDIQ 66
Query: 643 LIVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPL 702
+I EI++M+D +H NI+ + +YL+ D LW+ ME+ GGSL DI + + PL
Sbjct: 67 IIQQEIIMMRDCRHPNIIAYYGSYLR-RDKLWICMEFCGGGSLQDIYQVT-------GPL 118
Query: 703 TEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKR 762
TE QIAY+ RET +GL++LH +HRDIK N+LL G VK+ DFG A++T +KR
Sbjct: 119 TEVQIAYMCRETLKGLEYLHSMGKMHRDIKGANILLTEYGDVKLADFGVSAQITATINKR 178
Query: 763 ATMVGTPYWMAPEVV---KQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIAT 819
+ +GTPYWMAPEV ++ Y++ D+W+ GI IE+ E +PP + P++AL+L++
Sbjct: 179 KSFIGTPYWMAPEVAAVERKGGYNQLCDIWACGITAIELAELQPPMFDLHPMRALFLMSK 238
Query: 820 NG--TPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSFFNMSCE 867
+G P L + + S F+ L + K R + E LL H F + CE
Sbjct: 239 SGFKPPTLNNKDKWSPTFHNFIKTALTKNPKKRPTAERLLQHPF--VQCE 286
>Hs8393810_1 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 336
Score = 188 bits (478), Expect = 3e-47
Identities = 111/299 (37%), Positives = 160/299 (53%), Gaps = 27/299 (9%)
Query: 583 DPTPFFRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKE 642
DP+ + + E G+G G V+ ++ +KN G K A+K + +E
Sbjct: 16 DPSDTWEITETIGKGTYGKVF------------KVLNKKN--GQKAAVKILDPIHDIDEE 61
Query: 643 LIVNEILVMKDSKHNNIVNFLEAYLKTE----DDLWVVMEYMEGGSLTDIIENSPTGSSG 698
+ ++ S H N+V F Y K + D LW+V+E GGS+TD+++
Sbjct: 62 IEAEYNILKALSDHPNVVRFYGIYFKKDKVNGDKLWLVLELCSGGSVTDLVKGFLKRGER 121
Query: 699 QSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDK 758
S EP IAYI+ E GL+ LH+ IHRD+K +N+LL T G VK+ DFG A+LT
Sbjct: 122 MS---EPLIAYILHEALMGLQHLHNNKTIHRDVKGNNILLTTEGGVKLVDFGVSAQLTST 178
Query: 759 RSKRATMVGTPYWMAPEVVKQRE-----YDEKVDVWSLGIMTIEMLESEPPYLNEEPLKA 813
R +R T VGTP+WMAPEV+ + YD + D WSLGI IE+ + +PP + P++A
Sbjct: 179 RHRRNTSVGTPFWMAPEVIACEQQLDTTYDARCDTWSLGITAIELGDGDPPLADLHPMRA 238
Query: 814 LYLIATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSFFNMSCESQDLI 872
L+ I N PKL+ PE S E F+S CL D + R + ELL H F E +D++
Sbjct: 239 LFKIPRNPPPKLRQPELWSAEFNDFISKCLTKDYEKRPTVSELLQHKFIT-QIEGKDVM 296
>Hs20544910_1 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 336
Score = 188 bits (478), Expect = 3e-47
Identities = 111/299 (37%), Positives = 160/299 (53%), Gaps = 27/299 (9%)
Query: 583 DPTPFFRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKE 642
DP+ + + E G+G G V+ ++ +KN G K A+K + +E
Sbjct: 16 DPSDTWEITETIGKGTYGKVF------------KVLNKKN--GQKAAVKILDPIHDIDEE 61
Query: 643 LIVNEILVMKDSKHNNIVNFLEAYLKTE----DDLWVVMEYMEGGSLTDIIENSPTGSSG 698
+ ++ S H N+V F Y K + D LW+V+E GGS+TD+++
Sbjct: 62 IEAEYNILKALSDHPNVVRFYGIYFKKDKVNGDKLWLVLELCSGGSVTDLVKGFLKRGER 121
Query: 699 QSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDK 758
S EP IAYI+ E GL+ LH+ IHRD+K +N+LL T G VK+ DFG A+LT
Sbjct: 122 MS---EPLIAYILHEALMGLQHLHNNKTIHRDVKGNNILLTTEGGVKLVDFGVSAQLTST 178
Query: 759 RSKRATMVGTPYWMAPEVVKQRE-----YDEKVDVWSLGIMTIEMLESEPPYLNEEPLKA 813
R +R T VGTP+WMAPEV+ + YD + D WSLGI IE+ + +PP + P++A
Sbjct: 179 RHRRNTSVGTPFWMAPEVIACEQQLDTTYDARCDTWSLGITAIELGDGDPPLADLHPMRA 238
Query: 814 LYLIATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSFFNMSCESQDLI 872
L+ I N PKL+ PE S E F+S CL D + R + ELL H F E +D++
Sbjct: 239 LFKIPRNPPPKLRQPELWSAEFNDFISKCLTKDYEKRPTVSELLQHKFIT-QIEGKDVM 296
>Hs15451902 [T] KOG0576 Mitogen-activated protein kinase kinase kinase kinase
(MAP4K) germinal center kinase family
Length = 894
Score = 188 bits (477), Expect = 4e-47
Identities = 112/302 (37%), Positives = 161/302 (53%), Gaps = 27/302 (8%)
Query: 583 DPTPFFRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKE 642
+P F ++++ G G G VY A + G AIK + L
Sbjct: 11 NPQEDFELIQRIGSGTYGDVYKARNVNT--------------GELAAIKVIKLEPGEDFA 56
Query: 643 LIVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPL 702
++ EI++MKD KH NIV + +YL+ D LW+ ME+ GGSL DI + PL
Sbjct: 57 VVQQEIIMMKDCKHPNIVAYFGSYLR-RDKLWICMEFCGGGSLQDIYHVT-------GPL 108
Query: 703 TEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKR 762
+E QIAY+ RET QGL +LH K +HRDIK N+LL G VK+ DFG A++T +KR
Sbjct: 109 SELQIAYVSRETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKR 168
Query: 763 ATMVGTPYWMAPEVV---KQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIAT 819
+ +GTPYWMAPEV ++ Y++ D+W++GI IE+ E +PP + P++AL+L+
Sbjct: 169 KSFIGTPYWMAPEVAAVERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTK 228
Query: 820 NG--TPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSFFNMSCESQDLISLLEW 877
+ PKLK S F+ + L + K R + E+LL H F I LL+
Sbjct: 229 SNFQPPKLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQHLTRSLAIELLDK 288
Query: 878 KN 879
N
Sbjct: 289 VN 290
>Hs14589909 [T] KOG0576 Mitogen-activated protein kinase kinase kinase kinase
(MAP4K) germinal center kinase family
Length = 846
Score = 186 bits (471), Expect = 2e-46
Identities = 110/284 (38%), Positives = 154/284 (53%), Gaps = 27/284 (9%)
Query: 583 DPTPFFRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKE 642
+P + +V++ G G G VY A + G A+K + L
Sbjct: 15 NPQQDYELVQRVGSGTYGDVYKARNVHT--------------GELAAVKIIKLEPGDDFS 60
Query: 643 LIVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPL 702
LI EI ++K+ KH NIV + +YL E LW+ MEY GGSL DI + PL
Sbjct: 61 LIQQEIFMVKECKHCNIVAYFGSYLSREK-LWICMEYCGGGSLQDIYHVT-------GPL 112
Query: 703 TEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKR 762
+E QIAY+ RET QGL +LH K +HRDIK N+LL G VK+ DFG AK+T +KR
Sbjct: 113 SELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKR 172
Query: 763 ATMVGTPYWMAPEVV---KQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIAT 819
+ +GTPYWMAPEV K Y++ D+W++GI IE+ E +PP + P++AL+L++
Sbjct: 173 KSFIGTPYWMAPEVAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSK 232
Query: 820 NG--TPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSF 861
+ PKLK S F+ + L + K R + E LL H+F
Sbjct: 233 SNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTF 276
>CE28273 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 1096
Score = 185 bits (470), Expect = 2e-46
Identities = 107/301 (35%), Positives = 150/301 (49%), Gaps = 31/301 (10%)
Query: 583 DPTPFFRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKE 642
DP F ++E G G G VY ++ AIK M +++ E
Sbjct: 16 DPAGIFELIEVVGNGTYGQVYKGRHVKT--------------AQLAAIKIMNINEDEEDE 61
Query: 643 LIVNEILVMKDSKHNNIVNFLEAYLKT-------EDDLWVVMEYMEGGSLTDIIENSPTG 695
+ + ++ K S H N+ + A++K D LW+VME+ GS+TD+++N+ G
Sbjct: 62 IKLEINMLKKHSHHRNVATYYGAFIKKLPSSTGKHDQLWLVMEFCGSGSITDLVKNTKGG 121
Query: 696 SSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKL 755
S L E IAYI RE +GL LH +IHRDIK NVLL VK+ DFG A+L
Sbjct: 122 S-----LKEEWIAYICREILRGLYHLHQSKVIHRDIKGQNVLLTDSAEVKLVDFGVSAQL 176
Query: 756 TDKRSKRATMVGTPYWMAPEVV-----KQREYDEKVDVWSLGIMTIEMLESEPPYLNEEP 810
+R T +GTPYWMAPEV+ + YD + D+WSLGI +EM E PP + P
Sbjct: 177 DKTVGRRNTFIGTPYWMAPEVIACDESPEATYDSRSDLWSLGITALEMAEGHPPLCDMHP 236
Query: 811 LKALYLIATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSFFNMSCESQD 870
++AL+LI N PKLK + + + + F+ L D R T LL H F Q
Sbjct: 237 MRALFLIPRNPPPKLKRNKKWTKKFETFIETVLVKDYHQRPYTGALLRHPFIKEQPHEQT 296
Query: 871 L 871
+
Sbjct: 297 I 297
>CE25673 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 1082
Score = 185 bits (470), Expect = 2e-46
Identities = 107/301 (35%), Positives = 150/301 (49%), Gaps = 31/301 (10%)
Query: 583 DPTPFFRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKE 642
DP F ++E G G G VY ++ AIK M +++ E
Sbjct: 16 DPAGIFELIEVVGNGTYGQVYKGRHVKT--------------AQLAAIKIMNINEDEEDE 61
Query: 643 LIVNEILVMKDSKHNNIVNFLEAYLKT-------EDDLWVVMEYMEGGSLTDIIENSPTG 695
+ + ++ K S H N+ + A++K D LW+VME+ GS+TD+++N+ G
Sbjct: 62 IKLEINMLKKHSHHRNVATYYGAFIKKLPSSTGKHDQLWLVMEFCGSGSITDLVKNTKGG 121
Query: 696 SSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKL 755
S L E IAYI RE +GL LH +IHRDIK NVLL VK+ DFG A+L
Sbjct: 122 S-----LKEEWIAYICREILRGLYHLHQSKVIHRDIKGQNVLLTDSAEVKLVDFGVSAQL 176
Query: 756 TDKRSKRATMVGTPYWMAPEVV-----KQREYDEKVDVWSLGIMTIEMLESEPPYLNEEP 810
+R T +GTPYWMAPEV+ + YD + D+WSLGI +EM E PP + P
Sbjct: 177 DKTVGRRNTFIGTPYWMAPEVIACDESPEATYDSRSDLWSLGITALEMAEGHPPLCDMHP 236
Query: 811 LKALYLIATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSFFNMSCESQD 870
++AL+LI N PKLK + + + + F+ L D R T LL H F Q
Sbjct: 237 MRALFLIPRNPPPKLKRNKKWTKKFETFIETVLVKDYHQRPYTGALLRHPFIKEQPHEQT 296
Query: 871 L 871
+
Sbjct: 297 I 297
>CE25672 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 1087
Score = 185 bits (470), Expect = 2e-46
Identities = 107/301 (35%), Positives = 150/301 (49%), Gaps = 31/301 (10%)
Query: 583 DPTPFFRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKE 642
DP F ++E G G G VY ++ AIK M +++ E
Sbjct: 16 DPAGIFELIEVVGNGTYGQVYKGRHVKT--------------AQLAAIKIMNINEDEEDE 61
Query: 643 LIVNEILVMKDSKHNNIVNFLEAYLKT-------EDDLWVVMEYMEGGSLTDIIENSPTG 695
+ + ++ K S H N+ + A++K D LW+VME+ GS+TD+++N+ G
Sbjct: 62 IKLEINMLKKHSHHRNVATYYGAFIKKLPSSTGKHDQLWLVMEFCGSGSITDLVKNTKGG 121
Query: 696 SSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKL 755
S L E IAYI RE +GL LH +IHRDIK NVLL VK+ DFG A+L
Sbjct: 122 S-----LKEEWIAYICREILRGLYHLHQSKVIHRDIKGQNVLLTDSAEVKLVDFGVSAQL 176
Query: 756 TDKRSKRATMVGTPYWMAPEVV-----KQREYDEKVDVWSLGIMTIEMLESEPPYLNEEP 810
+R T +GTPYWMAPEV+ + YD + D+WSLGI +EM E PP + P
Sbjct: 177 DKTVGRRNTFIGTPYWMAPEVIACDESPEATYDSRSDLWSLGITALEMAEGHPPLCDMHP 236
Query: 811 LKALYLIATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSFFNMSCESQD 870
++AL+LI N PKLK + + + + F+ L D R T LL H F Q
Sbjct: 237 MRALFLIPRNPPPKLKRNKKWTKKFETFIETVLVKDYHQRPYTGALLRHPFIKEQPHEQT 296
Query: 871 L 871
+
Sbjct: 297 I 297
>Hs15011880 [T] KOG0201 Serine/threonine protein kinase
Length = 416
Score = 184 bits (468), Expect = 4e-46
Identities = 108/298 (36%), Positives = 161/298 (53%), Gaps = 27/298 (9%)
Query: 566 MSNAEIMTNLKNVTFNM-DPTPFFRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQL 624
M+++ + + + N+ DP F +E+ G+G+ G V+ + N+
Sbjct: 1 MAHSPVAVQVPGMQNNIADPEELFTKLERIGKGSFGEVF--------------KGIDNRT 46
Query: 625 GNKVAIKQMILSK-QPRKELIVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGG 683
VAIK + L + + E I EI V+ + + + +YLK LW++MEY+ GG
Sbjct: 47 QQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSSYVTKYYGSYLKGSK-LWIIMEYLGGG 105
Query: 684 SLTDIIENSPTGSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGR 743
S D++ P E QIA +++E +GL +LH + IHRDIK+ NVLL +G
Sbjct: 106 SALDLLR--------AGPFDEFQIATMLKEILKGLDYLHSEKKIHRDIKAANVLLSEQGD 157
Query: 744 VKITDFGFCAKLTDKRSKRATMVGTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEP 803
VK+ DFG +LTD + KR T VGTP+WMAPEV++Q YD K D+WSLGI IE+ + EP
Sbjct: 158 VKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSKADIWSLGITAIELAKGEP 217
Query: 804 PYLNEEPLKALYLIATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSF 861
P + P++ L+LI N P L + K F+ CL D +R + +ELL H F
Sbjct: 218 PNSDMHPMRVLFLIPKNNPPTLVGD--FTKSFKEFIDACLNKDPSFRPTAKELLKHKF 273
>At3g15220 [T] KOG0201 Serine/threonine protein kinase
Length = 690
Score = 183 bits (465), Expect = 9e-46
Identities = 108/287 (37%), Positives = 163/287 (56%), Gaps = 26/287 (9%)
Query: 588 FRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRK-ELIVN 646
F +E G+G+ G VY +A L +VAIK + L + + E I
Sbjct: 15 FSQIELIGRGSFGDVY--------------KAFDKDLNKEVAIKVIDLEESEDEIEDIQK 60
Query: 647 EILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQ 706
EI V+ + I + +YL + LW++MEYM GGS+ D+++++ +PL E
Sbjct: 61 EISVLSQCRCPYITEYYGSYLH-QTKLWIIMEYMAGGSVADLLQSN-------NPLDETS 112
Query: 707 IAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMV 766
IA I R+ +++LH++ IHRDIK+ N+LL G VK+ DFG A+LT S+R T V
Sbjct: 113 IACITRDLLHAVEYLHNEGKIHRDIKAANILLSENGDVKVADFGVSAQLTRTISRRKTFV 172
Query: 767 GTPYWMAPEVVKQRE-YDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTPKL 825
GTP+WMAPEV++ E Y+EK D+WSLGI IEM + EPP + P++ L++I P+L
Sbjct: 173 GTPFWMAPEVIQNSEGYNEKADIWSLGITVIEMAKGEPPLADLHPMRVLFIIPRETPPQL 232
Query: 826 KHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSFFNMSCESQDLI 872
E+ S ++K F+S+CL R S +EL+ H F + +S L+
Sbjct: 233 --DEHFSRQVKEFVSLCLKKAPAERPSAKELIKHRFIKNARKSPKLL 277
>Hs7657335 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 1295
Score = 181 bits (458), Expect = 6e-45
Identities = 109/289 (37%), Positives = 150/289 (51%), Gaps = 30/289 (10%)
Query: 583 DPTPFFRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKE 642
DP F +VE G G G VY ++ G AIK M +++ +E
Sbjct: 20 DPAGIFELVEVVGNGTYGQVYKGRHVKT--------------GQLAAIKVMDVTEDEEEE 65
Query: 643 LIVNEILVMKDSKHNNIVNFLEAYLK-----TEDDLWVVMEYMEGGSLTDIIENSPTGSS 697
+ ++ K S H NI + A++K +D LW+VME+ GS+TD+++N+ +
Sbjct: 66 IKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNA- 124
Query: 698 GQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTD 757
L E IAYI RE +GL LH +IHRDIK NVLL VK+ DFG A+L
Sbjct: 125 ----LKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDR 180
Query: 758 KRSKRATMVGTPYWMAPEVVKQRE-----YDEKVDVWSLGIMTIEMLESEPPYLNEEPLK 812
+R T +GTPYWMAPEV+ E YD + D+WSLGI IEM E PP + P++
Sbjct: 181 TVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMR 240
Query: 813 ALYLIATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSF 861
AL+LI N P+LK ++ S + F+ CL R TE+LL F
Sbjct: 241 ALFLIPRNPPPRLKSKKW-SKKFIDFIDTCLIKTYLSRPPTEQLLKFPF 288
>Hs7661994 [T] KOG0579 Ste20-like serine/threonine protein kinase
Length = 1152
Score = 179 bits (453), Expect = 2e-44
Identities = 105/291 (36%), Positives = 154/291 (52%), Gaps = 26/291 (8%)
Query: 576 KNVTFNMDPTPFFRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMIL 635
++V +++P F+ ++ + G GA G VY +A+ + A K +
Sbjct: 22 EHVKRDLNPEDFWEIIGELGDGAFGKVY--------------KAQNKETSVLAAAKVIDT 67
Query: 636 SKQPRKELIVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTG 695
+ E + EI ++ H NIV L+A+ E++LW+++E+ GG++ ++
Sbjct: 68 KSEEELEDYMVEIDILASCDHPNIVKLLDAFYY-ENNLWILIEFCAGGAVDAVMLEL--- 123
Query: 696 SSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKL 755
+ PLTE QI + ++T L +LHD IIHRD+K+ N+L G +K+ DFG AK
Sbjct: 124 ---ERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKN 180
Query: 756 TDKRSKRATMVGTPYWMAPEVV-----KQREYDEKVDVWSLGIMTIEMLESEPPYLNEEP 810
T +R + +GTPYWMAPEVV K R YD K DVWSLGI IEM E EPP+ P
Sbjct: 181 TRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNP 240
Query: 811 LKALYLIATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSF 861
++ L IA + P L P S K FL CL +V R +T +LL H F
Sbjct: 241 MRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPF 291
>7300224 [T] KOG0201 Serine/threonine protein kinase
Length = 642
Score = 179 bits (453), Expect = 2e-44
Identities = 110/305 (36%), Positives = 164/305 (53%), Gaps = 30/305 (9%)
Query: 579 TFNMDPTPFFRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSK- 637
T +DP F E+ G+G+ G V+ + N+ VAIK + L +
Sbjct: 4 TEKVDPELIFTKQERIGKGSFGEVF--------------KGIDNRTQQVVAIKIIDLEEA 49
Query: 638 QPRKELIVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSS 697
+ + I EI+V+ + + ++LK LW++MEY+ GGS D+++ GS
Sbjct: 50 EDEIDDIQQEIMVLSQCDSPYVTKYYGSFLKGTK-LWIIMEYLGGGSALDLMK---AGS- 104
Query: 698 GQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTD 757
E I I+RE +GL +LH + +HRDIK+ NVLL +G VK+ DFG +LT+
Sbjct: 105 ----FEEMHIGIILREVLKGLDYLHSERKLHRDIKAANVLLSEQGDVKLADFGVAGQLTN 160
Query: 758 KRSKRATMVGTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLI 817
SKR T VGTP+WMAPEV+KQ +YD K D+WSLGI IE+ + EPP P++ L+LI
Sbjct: 161 TTSKRNTFVGTPFWMAPEVIKQSQYDAKADIWSLGITAIELAKGEPPNSELHPMRVLFLI 220
Query: 818 ATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSFFNMSCESQDLISLLE- 876
N P+L + K F+ CL D + R + +ELL + F + ++ LI L++
Sbjct: 221 PKNNPPQLTGS--YTKSFKDFVEACLNKDPENRPTAKELLKYPFIKKAKKNAYLIDLIDR 278
Query: 877 ---WK 878
WK
Sbjct: 279 FKKWK 283
>At1g53165 [T] KOG0201 Serine/threonine protein kinase
Length = 1007
Score = 176 bits (446), Expect = 1e-43
Identities = 108/287 (37%), Positives = 157/287 (54%), Gaps = 26/287 (9%)
Query: 588 FRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRK-ELIVN 646
F E G+G+ G VY +A +L VAIK + L + + E I
Sbjct: 342 FSQFELIGRGSFGDVY--------------KAFDTELNKDVAIKVIDLEESEDEIEDIQK 387
Query: 647 EILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQ 706
EI V+ + I + +YL + LW++MEYM GGS+ D+++ +PL E
Sbjct: 388 EISVLSQCRCPYITEYYGSYLH-QTKLWIIMEYMAGGSVADLLQPG-------NPLDEIS 439
Query: 707 IAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMV 766
IA I R+ +++LH + IHRDIK+ N+LL G VK+ DFG A+LT S+R T V
Sbjct: 440 IACITRDLLHAVEYLHAEGKIHRDIKAANILLSENGDVKVADFGVSAQLTRTISRRKTFV 499
Query: 767 GTPYWMAPEVVKQRE-YDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTPKL 825
GTP+WMAPEV++ E Y+EK D+WSLGI IEM + EPP + P++ L++I P+L
Sbjct: 500 GTPFWMAPEVIQNSEGYNEKADIWSLGITMIEMAKGEPPLADLHPMRVLFIIPRESPPQL 559
Query: 826 KHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSFFNMSCESQDLI 872
E+ S +K F+S CL R + +ELL H F + +S L+
Sbjct: 560 --DEHFSRPLKEFVSFCLKKAPAERPNAKELLKHRFIKNARKSPKLL 604
>Hs5174701 [T] KOG0579 Ste20-like serine/threonine protein kinase
Length = 968
Score = 174 bits (442), Expect = 4e-43
Identities = 106/305 (34%), Positives = 156/305 (50%), Gaps = 26/305 (8%)
Query: 576 KNVTFNMDPTPFFRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMIL 635
++V ++DP + +V + G GA G VY +A+ + G A K +
Sbjct: 24 EHVRRDLDPNEVWEIVGELGDGAFGKVY--------------KAKNKETGALAAAKVIET 69
Query: 636 SKQPRKELIVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTG 695
+ E + EI ++ H IV L AY + LW+++E+ GG++ I+ G
Sbjct: 70 KSEEELEDYIVEIEILATCDHPYIVKLLGAYYH-DGKLWIMIEFCPGGAVDAIMLELDRG 128
Query: 696 SSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKL 755
LTEPQI + R+ + L FLH K IIHRD+K+ NVL+ G +++ DFG AK
Sbjct: 129 ------LTEPQIQVVCRQMLEALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKN 182
Query: 756 TDKRSKRATMVGTPYWMAPEVV-----KQREYDEKVDVWSLGIMTIEMLESEPPYLNEEP 810
KR + +GTPYWMAPEVV K YD K D+WSLGI IEM + EPP+ P
Sbjct: 183 LKTLQKRDSFIGTPYWMAPEVVMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNP 242
Query: 811 LKALYLIATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSFFNMSCESQD 870
++ L IA + P L P S+E + FL + L + + R S +LL H F + ++
Sbjct: 243 MRVLLKIAKSDPPTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLEHPFVSSITSNKA 302
Query: 871 LISLL 875
L L+
Sbjct: 303 LRELV 307
>Hs20428779_1 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 357
Score = 174 bits (441), Expect = 5e-43
Identities = 104/288 (36%), Positives = 148/288 (51%), Gaps = 26/288 (9%)
Query: 583 DPTPFFRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKE 642
DPT + ++E G+G G VY + + G+ A+K + +E
Sbjct: 22 DPTDTWEIIETIGKGTYGKVY--------------KVTNKRDGSLAAVKILDPVSDMDEE 67
Query: 643 LIVNEILVMKDSKHNNIVNFLEAYLKTED----DLWVVMEYMEGGSLTDIIENSPTGSSG 698
+ ++ H N+V F + K + LW+V+E GGS+T++++ G
Sbjct: 68 IEAEYNILQFLPNHPNVVKFYGMFYKADHCVGGQLWLVLELCNGGSVTELVKGLLR--CG 125
Query: 699 QSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDK 758
Q L E I+YI+ GL+ LH+ IIHRD+K +N+LL T G VK+ DFG A+LT
Sbjct: 126 QR-LDEAMISYILYGALLGLQHLHNNRIIHRDVKGNNILLTTEGGVKLVDFGVSAQLTST 184
Query: 759 RSKRATMVGTPYWMAPEVVK-----QREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKA 813
R +R T VGTP+WMAPEV+ YD + DVWSLGI IE+ + +PP + P+K
Sbjct: 185 RLRRNTSVGTPFWMAPEVIACEQQYDSSYDARCDVWSLGITAIELGDGDPPLFDMHPVKT 244
Query: 814 LYLIATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSF 861
L+ I N P L HPE E F+S CL D + R S LL H F
Sbjct: 245 LFKIPRNPPPTLLHPEKWCEEFNHFISQCLIKDFERRPSVTHLLDHPF 292
>CE07599 [T] KOG0576 Mitogen-activated protein kinase kinase kinase kinase
(MAP4K) germinal center kinase family
Length = 829
Score = 174 bits (440), Expect = 7e-43
Identities = 110/303 (36%), Positives = 162/303 (53%), Gaps = 28/303 (9%)
Query: 583 DPTPFFRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKE 642
+P + ++++ G G G VY A ++ D L A+K + L
Sbjct: 10 NPADDYELLQRVGSGTYGEVYKARDIR----SDSL----------AAVKVVKLEAGDNFA 55
Query: 643 LIVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPL 702
+I EI+V+++ H NI+ + +Y++ D LW+VMEY GGSL DI + PL
Sbjct: 56 VIQQEIMVIRECSHPNIIAYFGSYIR-RDRLWIVMEYCGGGSLQDIYHLT-------GPL 107
Query: 703 TEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKR 762
+E QIA++ RET +GL +LH+ IHRDIK N+LL + G VK+ DFG A++T KR
Sbjct: 108 SELQIAFVCRETLRGLNYLHNMGKIHRDIKGANILLSSSGDVKLADFGVAAQITATIGKR 167
Query: 763 ATMVGTPYWMAPEVV---KQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIAT 819
+ +GTPYWMAPEV K+ Y + DVW+ GI IE+ E +PP + P++ LYL+
Sbjct: 168 KSFIGTPYWMAPEVACVEKRGGYGMQCDVWATGITAIELGECQPPLFDLHPMQVLYLMTK 227
Query: 820 NG--TPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELL-HHSFFNMSCESQDLISLLE 876
+G P LK + F+ CL + K R S E+LL H F S ++ LL+
Sbjct: 228 SGYKPPHLKDKHRWTPLFHDFVRQCLTKNPKKRPSPEKLLTSHPFVLGSLSARMTRDLLD 287
Query: 877 WKN 879
N
Sbjct: 288 KVN 290
>Hs22035600 [T] KOG0576 Mitogen-activated protein kinase kinase kinase kinase
(MAP4K) germinal center kinase family
Length = 820
Score = 173 bits (439), Expect = 9e-43
Identities = 109/310 (35%), Positives = 165/310 (53%), Gaps = 28/310 (9%)
Query: 572 MTNLKNVTFNMDPTPFFRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIK 631
M L++V+ DP F ++++ G G G VY A +D + +E A+K
Sbjct: 1 MALLRDVSLQ-DPRDRFELLQRVGAGTYGDVYKA--------RDTVTSEL------AAVK 45
Query: 632 QMILSKQPRKELIVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIEN 691
+ L + EI ++++ +H N+V ++ +YL+ D LW+ ME+ GGSL +I
Sbjct: 46 IVKLDPGDDISSLQQEITILRECRHPNVVAYIGSYLRN-DRLWICMEFCGGGSLQEIYHA 104
Query: 692 SPTGSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGF 751
+ PL E QIAY+ RE +GL LH + IHRDIK N+LL +G VK+ DFG
Sbjct: 105 T-------GPLEERQIAYVCREALKGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGV 157
Query: 752 CAKLTDKRSKRATMVGTPYWMAPEVV---KQREYDEKVDVWSLGIMTIEMLESEPPYLNE 808
+LT +KR + +GTPYWMAPEV ++ Y+E DVW+LGI IE+ E +PP +
Sbjct: 158 SGELTASVAKRRSFIGTPYWMAPEVAAVERKGGYNELCDVWALGITAIELGELQPPLFHL 217
Query: 809 EPLKALYLIATNG--TPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSFFNMSC 866
P++AL L++ + PKL+ + FL + L + K R + E+LL H F
Sbjct: 218 HPMRALMLMSKSSFQPPKLRDKTRWTQNFHHFLKLALTKNPKKRPTAEKLLQHPFTTQQL 277
Query: 867 ESQDLISLLE 876
L LL+
Sbjct: 278 PRALLTQLLD 287
>Hs6005810 [T] KOG0576 Mitogen-activated protein kinase kinase kinase kinase
(MAP4K) germinal center kinase family
Length = 833
Score = 173 bits (438), Expect = 1e-42
Identities = 105/298 (35%), Positives = 161/298 (53%), Gaps = 27/298 (9%)
Query: 580 FNMDPTPFFRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQP 639
FN DP + ++++ G G G V+ A +D++ G+ VA+K + +
Sbjct: 9 FNRDPRDHYDLLQRLGGGTYGEVFKA--------RDKVS------GDLVALKMVKMEPDD 54
Query: 640 RKELIVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQ 699
+ EIL++K +H NIV + +YL + LW+ ME+ GSL DI + TGS
Sbjct: 55 DVSTLQKEILILKTCRHANIVAYHGSYLWLQK-LWICMEFCGAGSLQDIYQ--VTGS--- 108
Query: 700 SPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKR 759
L+E QI+Y+ RE QGL +LH + IHRDIK N+L++ G V++ DFG A++
Sbjct: 109 --LSELQISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATL 166
Query: 760 SKRATMVGTPYWMAPEVVK---QREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYL 816
++R + +GTPYWMAPEV + Y+E D+WSLGI IE+ E +PP + PL+ L+L
Sbjct: 167 ARRLSFIGTPYWMAPEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFL 226
Query: 817 IATNG--TPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSFFNMSCESQDLI 872
+ +G P+LK S F+ V L K R S ++L H + ++ LI
Sbjct: 227 MTKSGYQPPRLKEKGKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLI 284
>HsM4759010 [T] KOG0576 Mitogen-activated protein kinase kinase kinase kinase
(MAP4K) germinal center kinase family
Length = 819
Score = 172 bits (436), Expect = 2e-42
Identities = 106/299 (35%), Positives = 159/299 (52%), Gaps = 27/299 (9%)
Query: 583 DPTPFFRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKE 642
DP F ++++ G G G VY A +D + +E A+K + L
Sbjct: 10 DPRDRFELLQRVGAGTYGDVYKA--------RDTVTSEL------AAVKIVKLDPGDDIS 55
Query: 643 LIVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPL 702
+ EI ++++ +H N+V ++ +YL+ D LW+ ME+ GGSL +I + PL
Sbjct: 56 SLQQEITILRECRHPNVVAYIGSYLRN-DRLWICMEFCGGGSLQEIYHAT-------GPL 107
Query: 703 TEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKR 762
E QIAY+ RE +GL LH + IHRDIK N+LL +G VK+ DFG +LT +KR
Sbjct: 108 EERQIAYVCRERLKGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKR 167
Query: 763 ATMVGTPYWMAPEVV---KQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIAT 819
+ +GTPYWMAPEV ++ Y+E DVW+LGI IE+ E +PP + P++AL L++
Sbjct: 168 RSFIGTPYWMAPEVAAVERKGGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSK 227
Query: 820 NG--TPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSFFNMSCESQDLISLLE 876
+ PKL+ + FL + L + K R + E+LL H F L LL+
Sbjct: 228 SSFQPPKLRDKTRWTQNFHHFLKLALTKNPKKRPTAEKLLQHPFTTQQLPRALLTQLLD 286
>At3g07980 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 1367
Score = 168 bits (425), Expect = 4e-41
Identities = 101/280 (36%), Positives = 156/280 (55%), Gaps = 24/280 (8%)
Query: 588 FRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKEL--IV 645
+ + ++ G+GA G VY+ L+ E G+ VAIKQ+ L +++L I+
Sbjct: 20 YMLGDEIGKGAYGRVYIG-----------LDLEN---GDFVAIKQVSLENIGQEDLNTIM 65
Query: 646 NEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEP 705
EI ++K+ H NIV +L + LKT+ L +++EY+E GSL +II+ + G P E
Sbjct: 66 QEIDLLKNLNHKNIVKYLGS-LKTKTHLHIILEYVENGSLANIIKPNKFG-----PFPES 119
Query: 706 QIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATM 765
+ + + +GL +LH++ +IHRDIK N+L G VK+ DFG KL + ++
Sbjct: 120 LVTVYIAQVLEGLVYLHEQGVIHRDIKGANILTTKEGLVKLADFGVATKLNEADFNTHSV 179
Query: 766 VGTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTPKL 825
VGTPYWMAPEV++ D+WS+G IE+L PPY + +P+ ALY I + TP +
Sbjct: 180 VGTPYWMAPEVIELSGVCAASDIWSVGCTIIELLTCVPPYYDLQPMPALYRIVQDDTPPI 239
Query: 826 KHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSFFNMS 865
P+ LS +I FL +C D + R + LL H + S
Sbjct: 240 --PDSLSPDITDFLRLCFKKDSRQRPDAKTLLSHPWIRNS 277
>SPBC17F3.02 [T] KOG0201 Serine/threonine protein kinase
Length = 652
Score = 167 bits (423), Expect = 7e-41
Identities = 103/286 (36%), Positives = 156/286 (54%), Gaps = 31/286 (10%)
Query: 581 NMDPTPFFRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMIL-SKQP 639
N +P+ ++ E G+G+ G+VY N VAIK + L + +
Sbjct: 4 NTASSPYTKL-ELVGRGSYGAVY--------------RGICNLTKETVAIKILNLDTDED 48
Query: 640 RKELIVNEILVMKDSKHNNIVNFLE---AYLKTEDDLWVVMEYMEGGSLTDIIENSPTGS 696
I E+ V+ + K +++ N ++ +YL +LW++M+Y GGS+ ++E
Sbjct: 49 EVSDIQKEVAVLSELKQSDVENIIKYHGSYL-VGTNLWIIMDYCHGGSVRTLME------ 101
Query: 697 SGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLT 756
P++EP I+ I+RET Q LKF+H IIHRDIK+ N+L+ G VK+ DFG A+L
Sbjct: 102 --AGPISEPCISLILRETLQALKFIHHAGIIHRDIKAANILVSMSGNVKLCDFGVAAELN 159
Query: 757 DKRSKRATMVGTPYWMAPEVVKQ-REYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALY 815
R KR T +GTPYWMAPEV++ +EY+ D+WSLGI E+ PP+ E+P +A+Y
Sbjct: 160 INRRKRITFIGTPYWMAPEVIRDGQEYNVMADIWSLGITAYEIATGSPPHAKEDPFRAVY 219
Query: 816 LIATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSF 861
LIA P+L S +K F++ CL + R + ELL F
Sbjct: 220 LIAHTAPPRLN--GNFSALLKEFIASCLQDVPQRRLDSSELLKSKF 263
>Hs19923464 [T] KOG0577 Serine/threonine protein kinase
Length = 898
Score = 167 bits (423), Expect = 7e-41
Identities = 111/308 (36%), Positives = 161/308 (52%), Gaps = 33/308 (10%)
Query: 575 LKNVTFNMDPTPFFRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMI 634
+ ++ + DP F + + G G+ G+VY A A N++ VAIK+M
Sbjct: 11 IADLFYKDDPEELFIGLHEIGHGSFGAVYFATN-----------AHTNEV---VAIKKMS 56
Query: 635 LSKQPRKEL---IVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIEN 691
S + E I+ E+ ++ KH N + + YLK E W+VMEY G S +D++E
Sbjct: 57 YSGKQTHEKWQDILKEVKFLRQLKHPNTIEYKGCYLK-EHTAWLVMEYCLG-SASDLLEV 114
Query: 692 SPTGSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGF 751
+ PL E +IA I GL +LH +IHRDIK+ N+LL G+VK+ DFG
Sbjct: 115 H------KKPLQEVEIAAITHGALHGLAYLHSHALIHRDIKAGNILLTEPGQVKLADFGS 168
Query: 752 CAKLTDKRSKRATMVGTPYWMAPEVV---KQREYDEKVDVWSLGIMTIEMLESEPPYLNE 808
+ + S VGTPYWMAPEV+ + +YD KVD+WSLGI IE+ E +PP N
Sbjct: 169 ASMASPANS----FVGTPYWMAPEVILAMDEGQYDGKVDIWSLGITCIELAERKPPLFNM 224
Query: 809 EPLKALYLIATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSFFNMSCES 868
+ ALY IA N +P L+ E+ +RF+ CL + R ++ ELL H F
Sbjct: 225 NAMSALYHIAQNDSPTLQSNEWTD-SFRRFVDYCLQKIPQERPTSAELLRHDFVRRDRPL 283
Query: 869 QDLISLLE 876
+ LI L++
Sbjct: 284 RVLIDLIQ 291
>YHR102w [T] KOG0201 Serine/threonine protein kinase
Length = 1080
Score = 167 bits (422), Expect = 9e-41
Identities = 104/283 (36%), Positives = 148/283 (51%), Gaps = 27/283 (9%)
Query: 582 MDPTPFFRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMIL-SKQPR 640
MD + F+ E G+G G VY ++ G AIK + L S
Sbjct: 17 MDVSSLFKRTEVIGRGKFGVVYKGYNVKT--------------GRVYAIKVLNLDSDSDE 62
Query: 641 KELIVNEILVMKDSKH-NNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQ 699
E + EI + K +NI + +YLK + LW++ME+ GGSL ++
Sbjct: 63 VEDVQREIQFLASLKQISNITRYYGSYLK-DTSLWIIMEHCAGGSLRSLLR--------P 113
Query: 700 SPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKR 759
+ E I I+RE LK +H ++IHRDIK+ NVL+ G VK+ DFG A++
Sbjct: 114 GKIDEKYIGVIMRELLVALKCIHKDNVIHRDIKAANVLITNEGNVKLCDFGVAAQVNQTS 173
Query: 760 SKRATMVGTPYWMAPEVVKQR-EYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIA 818
+R TM GTPYWMAPEV+ + YD KVD+WSLGI T E+ PPY + E L+A+ LI
Sbjct: 174 LRRQTMAGTPYWMAPEVIMEGVYYDTKVDIWSLGITTYEIATGNPPYCDVEALRAMQLII 233
Query: 819 TNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSF 861
+ P+L+ Y S +K F+++CL D K R S ++LL F
Sbjct: 234 KSKPPRLEDRSY-STSLKEFIALCLDEDPKERLSADDLLKSKF 275
>SPAC9G1.09 [T] KOG0201 Serine/threonine protein kinase
Length = 471
Score = 165 bits (417), Expect = 3e-40
Identities = 99/293 (33%), Positives = 160/293 (53%), Gaps = 27/293 (9%)
Query: 588 FRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKEL-IVN 646
+ ++ K G G+ G V+ +A +N G+ +AIKQ+ L I
Sbjct: 9 YTLLRKLGSGSFGVVW--------------KARENVSGDIIAIKQIDLETGIDDITDIEQ 54
Query: 647 EILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQ 706
E+ ++ + +N++ + ++ LW++ME+M+GGS++ +++ L E
Sbjct: 55 EVFMLSNCNSSNVIQYYGCFVDGYT-LWILMEHMDGGSVSGLLK--------MGRLNEQV 105
Query: 707 IAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTR-GRVKITDFGFCAKLTDKRSKRATM 765
I+ I+RE GL +LH ++ IHRDIK+ N+LL + G VK+ DFG A+L++ S+R T
Sbjct: 106 ISIILREVLYGLNYLHGQNKIHRDIKAANILLSSSTGNVKLADFGVAAQLSNAASRRHTF 165
Query: 766 VGTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTPKL 825
VGTP+WMAPEV++Q Y D+WSLGI IEM PP P++ ++ I + PKL
Sbjct: 166 VGTPFWMAPEVIQQTSYGLAADIWSLGITAIEMANGIPPRATMHPMRVIFEIPQSEPPKL 225
Query: 826 KHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSFFNMSCESQDLISLLEWK 878
++ S + F+S CL ++ R S +ELL H F + +D+I LL K
Sbjct: 226 --DDHFSPTFRDFVSCCLDLNPNMRWSAKELLQHPFIKSAGTVKDIIPLLVQK 276
>At3g13530 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 1368
Score = 162 bits (410), Expect = 2e-39
Identities = 99/280 (35%), Positives = 153/280 (54%), Gaps = 24/280 (8%)
Query: 588 FRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKEL--IV 645
+ + ++ G+GA G VY L+ E G+ VAIKQ+ L +++L I+
Sbjct: 20 YMLGDEIGKGAYGRVYKG-----------LDLEN---GDFVAIKQVSLENIVQEDLNTIM 65
Query: 646 NEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEP 705
EI ++K+ H NIV +L + KT+ L +++EY+E GSL +II+ + G P E
Sbjct: 66 QEIDLLKNLNHKNIVKYLGSS-KTKTHLHIILEYVENGSLANIIKPNKFG-----PFPES 119
Query: 706 QIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATM 765
+A + + +GL +LH++ +IHRDIK N+L G VK+ DFG KL + ++
Sbjct: 120 LVAVYIAQVLEGLVYLHEQGVIHRDIKGANILTTKEGLVKLADFGVATKLNEADVNTHSV 179
Query: 766 VGTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTPKL 825
VGTPYWMAPEV++ D+WS+G IE+L PPY + +P+ AL+ I + P +
Sbjct: 180 VGTPYWMAPEVIEMSGVCAASDIWSVGCTVIELLTCVPPYYDLQPMPALFRIVQDDNPPI 239
Query: 826 KHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSFFNMS 865
P+ LS +I FL C D + R + LL H + S
Sbjct: 240 --PDSLSPDITDFLRQCFKKDSRQRPDAKTLLSHPWIRNS 277
>7297240_1 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 326
Score = 160 bits (405), Expect = 8e-39
Identities = 99/298 (33%), Positives = 149/298 (49%), Gaps = 28/298 (9%)
Query: 583 DPTPFFRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKE 642
DPT F + E+ QG + V+ A+ L D + A K Q + + +
Sbjct: 11 DPTDKFEIYEEIAQGVNAKVFRAKELD----NDRIVALKIQHYD-----------EEHQV 55
Query: 643 LIVNEILVMKD-SKHNNIVNFLEAYLKTE----DDLWVVMEYMEGGSLTDIIENSPTGSS 697
I E ++D H N+ F Y ++ D++W VMEY GG+ D++
Sbjct: 56 SIEEEYRTLRDYCDHPNLPEFYGVYKLSKPNGPDEIWFVMEYCAGGTAVDMVNKL---LK 112
Query: 698 GQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTD 757
+ E IAYI+RETC+ L+ H++HRDI+ DN+LL GRVK+ DFG ++
Sbjct: 113 LDRRMREEHIAYIIRETCRAAIELNRNHVLHRDIRGDNILLTKNGRVKLCDFGLSRQVDS 172
Query: 758 KRSKRATMVGTPYWMAPEVVKQREYDE-----KVDVWSLGIMTIEMLESEPPYLNEEPLK 812
KR T +G+P WMAPEVV E E + DVW+LGI TIE+ + +PP+ + P +
Sbjct: 173 TLGKRGTCIGSPCWMAPEVVSAMESREPDITVRADVWALGITTIELADGKPPFADMHPTR 232
Query: 813 ALYLIATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSFFNMSCESQD 870
A++ I N P L P S +I F+S L + + R E++ H F E++D
Sbjct: 233 AMFQIIRNPPPTLMRPTNWSQQINDFISESLEKNAENRPMMVEMVEHPFLTELIENED 290
>Hs4826878 [T] KOG0582 Ste20-like serine/threonine protein kinase
Length = 527
Score = 160 bits (404), Expect = 1e-38
Identities = 100/251 (39%), Positives = 139/251 (54%), Gaps = 16/251 (6%)
Query: 627 KVAIKQMILSK-QPRKELIVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSL 685
KVAIK++ L K Q + ++ EI M H NIV++ +++ +D+LW+VM+ + GGS+
Sbjct: 42 KVAIKRINLEKCQTSMDELLKEIQAMSQCHHPNIVSYYTSFV-VKDELWLVMKLLSGGSV 100
Query: 686 TDIIENSPT-GSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRV 744
DII++ G L E IA I+RE +GL++LH IHRD+K+ N+LL G V
Sbjct: 101 LDIIKHIVAKGEHKSGVLDESTIATILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSV 160
Query: 745 KITDFGFCAKLT-----DKRSKRATMVGTPYWMAPEVVKQ-REYDEKVDVWSLGIMTIEM 798
+I DFG A L + R T VGTP WMAPEV++Q R YD K D+WS GI IE+
Sbjct: 161 QIADFGVSAFLATGGDITRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIEL 220
Query: 799 LESEPPYLNEEPLKALYLIATNGTPKL----KHPEYL---SLEIKRFLSVCLCVDVKYRA 851
PY P+K L L N P L + E L ++ +S+CL D + R
Sbjct: 221 ATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRP 280
Query: 852 STEELLHHSFF 862
+ ELL H FF
Sbjct: 281 TAAELLRHKFF 291
>Hs7706401 [T] KOG0577 Serine/threonine protein kinase
Length = 1235
Score = 157 bits (398), Expect = 5e-38
Identities = 106/288 (36%), Positives = 152/288 (51%), Gaps = 33/288 (11%)
Query: 580 FNMDPTPFFRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQP 639
F DP F + + G G+ G+VY A +D +E VAIK+M S +
Sbjct: 20 FKDDPEKLFSDLREIGHGSFGAVYFA--------RDVRNSEV------VAIKKMSYSGKQ 65
Query: 640 RKEL---IVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGS 696
E I+ E+ ++ +H N + + YL+ E W+VMEY G S +D++E
Sbjct: 66 SNEKWQDIIKEVRFLQKLRHPNTIQYRGCYLR-EHTAWLVMEYCLG-SASDLLEVH---- 119
Query: 697 SGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLT 756
+ PL E +IA + QGL +LH ++IHRD+K+ N+LL G VK+ DFG + +
Sbjct: 120 --KKPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMA 177
Query: 757 DKRSKRATMVGTPYWMAPEVV---KQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKA 813
S VGTPYWMAPEV+ + +YD KVDVWSLGI IE+ E +PP N + A
Sbjct: 178 PANS----FVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSA 233
Query: 814 LYLIATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSF 861
LY IA N +P L+ + S + F+ CL + R ++E LL H F
Sbjct: 234 LYHIAQNESPVLQSGHW-SEYFRNFVDSCLQKIPQDRPTSEVLLKHRF 280
>Hs4759208 [T] KOG0577 Serine/threonine protein kinase
Length = 1049
Score = 157 bits (398), Expect = 5e-38
Identities = 106/288 (36%), Positives = 152/288 (51%), Gaps = 33/288 (11%)
Query: 580 FNMDPTPFFRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQP 639
F DP F + + G G+ G+VY A +D +E VAIK+M S +
Sbjct: 20 FKDDPEKLFSDLREIGHGSFGAVYFA--------RDVRNSEV------VAIKKMSYSGKQ 65
Query: 640 RKEL---IVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGS 696
E I+ E+ ++ +H N + + YL+ E W+VMEY G S +D++E
Sbjct: 66 SNEKWQDIIKEVRFLQKLRHPNTIQYRGCYLR-EHTAWLVMEYCLG-SASDLLEVH---- 119
Query: 697 SGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLT 756
+ PL E +IA + QGL +LH ++IHRD+K+ N+LL G VK+ DFG + +
Sbjct: 120 --KKPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMA 177
Query: 757 DKRSKRATMVGTPYWMAPEVV---KQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKA 813
S VGTPYWMAPEV+ + +YD KVDVWSLGI IE+ E +PP N + A
Sbjct: 178 PANS----FVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSA 233
Query: 814 LYLIATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSF 861
LY IA N +P L+ + S + F+ CL + R ++E LL H F
Sbjct: 234 LYHIAQNESPVLQSGHW-SEYFRNFVDSCLQKIPQDRPTSEVLLKHRF 280
>SPAC2C4.14c [T] KOG0201 Serine/threonine protein kinase
Length = 312
Score = 155 bits (393), Expect = 2e-37
Identities = 102/296 (34%), Positives = 156/296 (52%), Gaps = 28/296 (9%)
Query: 588 FRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMIL-SKQPRKELIVN 646
+R ++ GQG+ GSV+ A+ + E +++ VA+K + L + + + E +
Sbjct: 6 YRDLQLIGQGSFGSVFRAQ-----------DVESSKI---VALKVVDLDATKDQIETLTQ 51
Query: 647 EILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQ 706
EI + D +I + +++ LW+ MEY +GGS D+++ S T S E
Sbjct: 52 EINFLIDLNSVHITKYYASFVDGFR-LWITMEYCDGGSCLDLLKLSGTFS-------ERV 103
Query: 707 IAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMV 766
IA ++R+ + L +LH + +HRDIK+ N+L G VK+ DFG +L R K V
Sbjct: 104 IAEVMRQVLEALVYLHGQGKMHRDIKAANILTMKDGLVKLADFGVSGQLESLRDKNDDFV 163
Query: 767 GTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTPKLK 826
GTP+WMAPEVVKQ Y+ K D+WSLGI E+ EPPY P+K L LI + P L+
Sbjct: 164 GTPFWMAPEVVKQTGYNYKADIWSLGITAYELATGEPPYSGIHPMKVLLLIPKHSPPSLE 223
Query: 827 HPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSFFNMSCES----QDLISLLEWK 878
++ S F+S CL + K RA+ E L H F C + + + S +WK
Sbjct: 224 RSKF-SRAFCDFVSNCLKKNPKDRATAEYLSKHKFIKKYCPNTSVKEVVASYAKWK 278
>At5g14720 [T] KOG0582 Ste20-like serine/threonine protein kinase
Length = 561
Score = 154 bits (389), Expect = 6e-37
Identities = 107/296 (36%), Positives = 150/296 (50%), Gaps = 29/296 (9%)
Query: 588 FRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRK-ELIVN 646
+++ E+ G G S +V+ A L +P L VAIK + L K + I
Sbjct: 16 YKLYEEIGDGVSATVHRA--LCIP------------LNVVVAIKVLDLEKCNNDLDGIRR 61
Query: 647 EILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENS-PTGSSGQSPLTEP 705
E+ M H N++ T LWVVM YM GGS II++S P G EP
Sbjct: 62 EVQTMSLINHPNVLQ-AHCSFTTGHQLWVVMPYMAGGSCLHIIKSSYPDG------FEEP 114
Query: 706 QIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKL---TDKRSKR 762
IA ++RET + L +LH IHRD+K+ N+LLD+ G VK+ DFG A + D++ R
Sbjct: 115 VIATLLRETLKALVYLHAHGHIHRDVKAGNILLDSNGAVKLADFGVSACMFDTGDRQRSR 174
Query: 763 ATMVGTPYWMAPEVVKQ-REYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNG 821
T VGTP WMAPEV++Q YD K DVWS GI +E+ P+ P+K L + N
Sbjct: 175 NTFVGTPCWMAPEVMQQLHGYDFKADVWSFGITALELAHGHAPFSKYPPMKVLLMTLQNA 234
Query: 822 TPKL--KHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSFFNMSCESQDLISLL 875
P L + + S K + CL D K R ++E+LL H FF + + L+ +
Sbjct: 235 PPGLDYERDKRFSKAFKEMVGTCLVKDPKKRPTSEKLLKHPFFKHARPADYLVKTI 290
>7293601 [T] KOG0577 Serine/threonine protein kinase
Length = 1039
Score = 154 bits (388), Expect = 7e-37
Identities = 110/299 (36%), Positives = 149/299 (49%), Gaps = 33/299 (11%)
Query: 583 DPTPFFRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKE 642
DP F + + G G+ G+VY A N VAIK+M + + +E
Sbjct: 22 DPEKIFEDLREIGHGSFGAVYYARC--------------NLTREIVAIKKMSYTGKQSQE 67
Query: 643 L---IVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQ 699
I+ EI ++ H N + + YL+ E W+VMEY G S +DIIE +
Sbjct: 68 KWQDILKEIRFLRQLNHPNTIEYKGCYLR-ESTAWLVMEYCVG-SASDIIEVH------K 119
Query: 700 SPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKR 759
PL E +IA I GL +LH IHRDIK+ N+LL G VK+ DFG A
Sbjct: 120 KPLHEDEIAAICLGVLSGLSYLHSLGRIHRDIKAGNILLTDNGVVKLADFGSAAIKCPAN 179
Query: 760 SKRATMVGTPYWMAPEVV---KQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYL 816
S VGTPYWMAPEV+ + +YD KVDVWSLGI IE+ E +PPY N + ALY
Sbjct: 180 S----FVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPYFNMNAMSALYH 235
Query: 817 IATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSFFNMSCESQDLISLL 875
IA N +P L ++ S F+ +CL R S+ +LL H++ L+ L+
Sbjct: 236 IAQNESPTLPKNDW-SDAFCSFVELCLKKMPAERPSSAKLLTHAYVTRPRSDTVLLELI 293
>SPBC1D7.05c [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 362
Score = 151 bits (381), Expect = 5e-36
Identities = 95/281 (33%), Positives = 149/281 (52%), Gaps = 38/281 (13%)
Query: 595 GQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMIL-----SKQPRKELI---VN 646
G G+ G VYL + A +L +A+KQ+IL SK +L+
Sbjct: 104 GSGSFGQVYLG-----------MNASSGEL---MAVKQVILDSVSESKDRHAKLLDALAG 149
Query: 647 EILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQ 706
EI ++++ H +IV +L + L + D L + +EY+ GGS+ ++ + E
Sbjct: 150 EIALLQELSHEHIVQYLGSNLNS-DHLNIFLEYVPGGSVAGLL-------TMYGSFEETL 201
Query: 707 IAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKL------TDKRS 760
+ +++T +GL++LH + I+HRDIK N+L+D +G++KI+DFG KL T
Sbjct: 202 VKNFIKQTLKGLEYLHSRGIVHRDIKGANILVDNKGKIKISDFGISKKLELNSTSTKTGG 261
Query: 761 KRATMVGTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATN 820
R + G+ +WMAPEVVKQ + EK D+WSLG + IEML S+ PY N + ++A++ I N
Sbjct: 262 ARPSFQGSSFWMAPEVVKQTMHTEKTDIWSLGCLVIEMLTSKHPYPNCDQMQAIFRIGEN 321
Query: 821 GTPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSF 861
P+ P +S FL +D R + ELL H F
Sbjct: 322 ILPEF--PSNISSSAIDFLEKTFAIDCNLRPTASELLSHPF 360
>Hs7019543 [T] KOG0582 Ste20-like serine/threonine protein kinase
Length = 547
Score = 150 bits (379), Expect = 8e-36
Identities = 98/264 (37%), Positives = 138/264 (52%), Gaps = 16/264 (6%)
Query: 627 KVAIKQMILSK-QPRKELIVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSL 685
+VAIK++ L K Q + ++ EI M H N+V + +++ +D+LW+VM+ + GGS+
Sbjct: 90 RVAIKRINLEKCQTSMDELLKEIQAMSQCSHPNVVTYYTSFV-VKDELWLVMKLLSGGSM 148
Query: 686 TDIIENSPT-GSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRV 744
DII+ G L E IA I++E +GL +LH IHRD+K+ N+LL G V
Sbjct: 149 LDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGLDYLHRNGQIHRDLKAGNILLGEDGSV 208
Query: 745 KITDFGFCAKL-----TDKRSKRATMVGTPYWMAPEVVKQ-REYDEKVDVWSLGIMTIEM 798
+I DFG A L + R T VGTP WMAPEV++Q R YD K D+WS GI IE+
Sbjct: 209 QIADFGVSAFLATGGDVTRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADMWSFGITAIEL 268
Query: 799 LESEPPYLNEEPLKALYLIATNGTPKL-------KHPEYLSLEIKRFLSVCLCVDVKYRA 851
PY P+K L L N P L + + ++ LS+CL D R
Sbjct: 269 ATGAAPYHKYPPMKVLMLTLQNDPPTLETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRP 328
Query: 852 STEELLHHSFFNMSCESQDLISLL 875
+ ELL FF + + LI L
Sbjct: 329 TAAELLKCKFFQKAKNREYLIEKL 352
>YDR523c [T] KOG0201 Serine/threonine protein kinase
Length = 490
Score = 149 bits (377), Expect = 1e-35
Identities = 101/281 (35%), Positives = 145/281 (50%), Gaps = 26/281 (9%)
Query: 584 PTPFFRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRK-E 642
P+ + + G+G G VY A D + E VAIK + L E
Sbjct: 14 PSKLYSIQSCIGRGNFGDVYKAV--------DRVTQEI------VAIKVVNLEHSDEDIE 59
Query: 643 LIVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPL 702
L+ EI + + K I N++ L+ + +W+VMEY GGS +D+++ S L
Sbjct: 60 LLAQEIFFLAELKSPLITNYIATMLE-DVSMWIVMEYCGGGSCSDLLKRSYVNG-----L 113
Query: 703 TEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKR 762
E ++++I+ E GLK+LH++ IHRDIK+ N+LL+ G VK+ DFG + KR
Sbjct: 114 PEEKVSFIIHEVTLGLKYLHEQRKIHRDIKAANILLNEEGMVKLGDFGVSGHIR-STLKR 172
Query: 763 ATMVGTPYWMAPEVV--KQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATN 820
T VGTPYWMAPEVV + Y+EK D+WSLGI T E+L+ PP +P+K + +
Sbjct: 173 DTFVGTPYWMAPEVVCCEVDGYNEKADIWSLGITTYELLKGLPPLSKYDPMKVMTNLPKR 232
Query: 821 GTPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSF 861
PKL+ P S K F++ CL R S LL F
Sbjct: 233 KPPKLQGP--FSDAAKDFVAGCLVKTPADRPSAYNLLSFEF 271
>YLR362w [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 717
Score = 149 bits (375), Expect = 2e-35
Identities = 83/225 (36%), Positives = 132/225 (57%), Gaps = 13/225 (5%)
Query: 642 ELIVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSP 701
+ + +E+ ++K+ H NIV + A + +L + +EY+ GGS++ ++ N P
Sbjct: 499 DALQHEMNLLKELHHENIVTYYGAS-QEGGNLNIFLEYVPGGSVSSMLNN-------YGP 550
Query: 702 LTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTD---K 758
E I R+ G+ +LH K+IIHRDIK N+L+D +G VKITDFG KL+ K
Sbjct: 551 FEESLITNFTRQILIGVAYLHKKNIIHRDIKGANILIDIKGCVKITDFGISKKLSPLNKK 610
Query: 759 RSKRATMVGTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIA 818
++KRA++ G+ +WM+PEVVKQ K D+WS G + IEM + P+ + ++A++ I
Sbjct: 611 QNKRASLQGSVFWMSPEVVKQTATTAKADIWSTGCVVIEMFTGKHPFPDFSQMQAIFKIG 670
Query: 819 TNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSFFN 863
TN TP++ P + + E K FL +D +YR S ELL H + +
Sbjct: 671 TNTTPEI--PSWATSEGKNFLRKAFELDYQYRPSALELLQHPWLD 713
>SPBC21.06c [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 1062
Score = 147 bits (372), Expect = 5e-35
Identities = 97/273 (35%), Positives = 144/273 (52%), Gaps = 28/273 (10%)
Query: 595 GQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKELIV--NEILVMK 652
G+GA G+VY + KN G VA+K++ LSK + +L V EI ++K
Sbjct: 16 GKGAFGAVYRGLNI------------KN--GETVAVKKVKLSKMLKSDLSVIKMEIDLLK 61
Query: 653 DSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAYIVR 712
+ H NIV + +Y +T D L +++EY E GSL I +N G+ P E +A
Sbjct: 62 NLDHPNIVKYRGSY-QTNDSLCIILEYCENGSLRSICKNF-----GKIP--ENLVALYTF 113
Query: 713 ETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMVGTPYWM 772
+ QGL +LH++ +IHRDIK N+L G +K+ DFG K+ ++VG+PYWM
Sbjct: 114 QVLQGLLYLHNQGVIHRDIKGANILTTKDGTIKLADFGVATKINALEDH--SVVGSPYWM 171
Query: 773 APEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTPKLKHPEYLS 832
APEV++ D+WS+G IE+L+ PPY + +P AL+ + + P L P +S
Sbjct: 172 APEVIELVGATTASDIWSVGCTVIELLDGNPPYYDLDPTSALFRMVKDEHPPL--PSNIS 229
Query: 833 LEIKRFLSVCLCVDVKYRASTEELLHHSFFNMS 865
K FL C D R T +LL H + M+
Sbjct: 230 SAAKSFLMQCFQKDPNLRIKTRKLLKHPWVIMN 262
>SPAC1F3.02c [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 1116
Score = 147 bits (371), Expect = 7e-35
Identities = 104/294 (35%), Positives = 156/294 (52%), Gaps = 39/294 (13%)
Query: 592 EKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSK--QPRKELIVN--- 646
E G G G V+LA + EL A K +V I Q I + Q RK+++ +
Sbjct: 829 ELIGNGTYGKVFLAMNINT----GELIAVK-----QVEIPQTINGRHDQLRKDIVDSINA 879
Query: 647 EILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQ 706
EI ++ D H NIV +L + KTE D+ + +EY+ GGS+ + N P E
Sbjct: 880 EISMIADLDHLNIVQYL-GFEKTETDISIFLEYVSGGSIGRCLRN-------YGPFEEQL 931
Query: 707 IAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDK---RSKRA 763
+ ++ R+ GL +LH K IIHRD+K+DN+L+D G KI+DFG +K +D
Sbjct: 932 VRFVSRQVLYGLSYLHSKGIIHRDLKADNLLIDFDGVCKISDFGI-SKHSDNVYDNDANL 990
Query: 764 TMVGTPYWMAPEVV--KQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNG 821
+M G+ +WMAPEV+ + Y KVDVWSLG + +EML P+ +E ++A++ + G
Sbjct: 991 SMQGSIFWMAPEVIHNDHQGYSAKVDVWSLGCVVLEMLAGRRPWSTDEAIQAMFKL---G 1047
Query: 822 TPKLKHP------EYLSLEIKRFLSVCLCVDVKYRASTEELLHHSFFNMSCESQ 869
T K P +S E +FL+ C V+ R + EELL+H F M C+ +
Sbjct: 1048 TEKKAPPIPSELVSQVSPEAIQFLNACFTVNADVRPTAEELLNHPF--MKCDEE 1099
>CE26212 [T] KOG0582 Ste20-like serine/threonine protein kinase
Length = 545
Score = 146 bits (368), Expect = 2e-34
Identities = 102/307 (33%), Positives = 155/307 (50%), Gaps = 34/307 (11%)
Query: 588 FRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSK-QPRKELIVN 646
+++ E G GA+ +V+ A L +N+ KVAIK + L K Q + + +
Sbjct: 57 YKLDESIGVGATATVFTAYCLP-----------RNE---KVAIKCINLEKCQTSVDELSH 102
Query: 647 EILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSP----L 702
EI M H N+V++ +++ +++LWVVM + GS+ DI++ + L
Sbjct: 103 EIQAMSQCNHPNVVSYYTSFI-AQEELWVVMRLLNCGSMLDILKRKVKAIGKEQAQFGVL 161
Query: 703 TEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLT------ 756
E IA ++RE +GL++ H IHRDIK+ N+LL G ++I DFG L
Sbjct: 162 DEVSIATVLREVLKGLEYFHLNGQIHRDIKAGNILLADDGTIQIADFGVSGWLASSGGDL 221
Query: 757 DKRSKRATMVGTPYWMAPEVVKQ-REYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALY 815
++ R T VGTP WMAPEV++Q + YD K D+WSLGI+ IE+ PY P+K L
Sbjct: 222 SRQKVRHTFVGTPCWMAPEVMEQVQGYDFKADIWSLGILAIELATGTAPYHKYPPMKVLM 281
Query: 816 LIATNGTPKL-----KHPEYLSL--EIKRFLSVCLCVDVKYRASTEELLHHSFFNMSCES 868
L N P L + +Y + K + CL D R + ELL +SFF +
Sbjct: 282 LTLQNDPPTLETNAERKDQYKAYGKSFKTLIRDCLQKDPAKRPTASELLKYSFFKKGKDK 341
Query: 869 QDLISLL 875
+ L+ L
Sbjct: 342 KYLVHTL 348
>CE07905 [T] KOG0579 Ste20-like serine/threonine protein kinase
Length = 1228
Score = 145 bits (365), Expect = 3e-34
Identities = 89/297 (29%), Positives = 147/297 (48%), Gaps = 24/297 (8%)
Query: 581 NMDPTPFFRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPR 640
N++P + ++ + G GA G V E + A K + + +
Sbjct: 27 NVNPRDHWNIIGELGDGAFGKV-------------EKAVSRTDPKLFAASKSIEIQEGEE 73
Query: 641 KELIVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQS 700
E + EI ++ + K + ++ L + E+ L +++E+ GG++ +II
Sbjct: 74 LEDFLVEIEILSECKGHPVMLGLYSTYFFENKLTMLLEFCGGGAVDNIIVELG------H 127
Query: 701 PLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRS 760
L E QI YI C LK+LH +++IHRD+K+ N+LL G+V++ DFG AKL +R
Sbjct: 128 VLKEDQIRYIGYYVCDALKWLHSQNVIHRDLKAGNILLTQDGQVRLADFGVSAKLKSERE 187
Query: 761 KRATMVGTPYWMAPEVV-----KQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALY 815
KR T +GTPYWMAPEV+ K + YD D+WS GI IEM + EPP+ + ++ +
Sbjct: 188 KRDTFIGTPYWMAPEVMACETFKDQPYDCISDIWSFGITLIEMAQGEPPHSDVSVMRVII 247
Query: 816 LIATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSFFNMSCESQDLI 872
+ + P L P + + L+ CL D + R E+ H +F + + +I
Sbjct: 248 KVQKSEPPTLLQPSHWTRSFSDILTRCLVKDPRNRPPAAEIFKHQWFQNAPSKRKMI 304
>CE01405 [T] KOG0577 Serine/threonine protein kinase
Length = 982
Score = 145 bits (365), Expect = 3e-34
Identities = 106/308 (34%), Positives = 154/308 (49%), Gaps = 39/308 (12%)
Query: 581 NMDPTPFFRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPR 640
N DP ++ + + G G+ G+VY A +KN+ VAIK+M S +
Sbjct: 23 NKDPEQRYQDLREIGHGSFGAVYFAYD------------KKNE--QTVAIKKMNFSGKQA 68
Query: 641 KEL---IVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSS 697
E I+ E+ + H +IV++ +LK + W+VMEY G S DI++ G
Sbjct: 69 VEKWNDILKEVSFLNTVVHPHIVDYKACFLK-DTTCWLVMEYCIG-SAADIVDVLRKG-- 124
Query: 698 GQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTD 757
+ E +IA I +T L++LH IHRDIK+ N+LL VK+ DFG A L D
Sbjct: 125 ----MREVEIAAICSQTLDALRYLHSLKRIHRDIKAGNILLSDHAIVKLADFG-SASLVD 179
Query: 758 KRSKRATMVGTPYWMAPEVV---KQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKAL 814
T +GTP++MAPEV+ + Y ++ D+WSLGI IE+ E PP + + AL
Sbjct: 180 PAQ---TFIGTPFFMAPEVILAMDEGHYTDRADIWSLGITCIELAERRPPLFSMNAMSAL 236
Query: 815 YLIATNGTPKL------KHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSFFNMSCES 868
Y IA N P L + PE+ SLE +F+ CL + R S EE H F S S
Sbjct: 237 YHIAQNDPPTLSPIDTSEQPEW-SLEFVQFIDKCLRKPAEERMSAEECFRHPFIQRSRPS 295
Query: 869 QDLISLLE 876
+ L++
Sbjct: 296 DTIQELIQ 303
>Hs22065589 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 1191
Score = 144 bits (364), Expect = 5e-34
Identities = 82/190 (43%), Positives = 108/190 (56%), Gaps = 11/190 (5%)
Query: 677 MEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNV 736
ME+ GS+TD+++N+ + L E IAYI RE +GL LH +IHRDIK NV
Sbjct: 1 MEFCGAGSVTDLVKNTKGNA-----LKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNV 55
Query: 737 LLDTRGRVKITDFGFCAKLTDKRSKRATMVGTPYWMAPEVVKQRE-----YDEKVDVWSL 791
LL VK+ DFG A+L +R T +GTPYWMAPEV+ E YD + D+WSL
Sbjct: 56 LLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSL 115
Query: 792 GIMTIEMLESEPPYLNEEPLKALYLIATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYRA 851
GI IEM E PP + P++AL+LI N P+LK ++ S + F+ CL R
Sbjct: 116 GITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKW-SKKFIDFIDTCLIKTYLSRP 174
Query: 852 STEELLHHSF 861
TE+LL F
Sbjct: 175 PTEQLLKFPF 184
>At3g06030 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 651
Score = 141 bits (356), Expect = 4e-33
Identities = 95/290 (32%), Positives = 147/290 (49%), Gaps = 36/290 (12%)
Query: 584 PTPFFRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSK------ 637
P+ +R E G GA G VY+ L G +AIKQ++++
Sbjct: 64 PSIRWRKGELIGCGAFGRVYMGMNLDS--------------GELLAIKQVLIAPSSASKE 109
Query: 638 --QPRKELIVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTG 695
Q + E+ ++K+ H NIV +L ++ D L ++ME++ GGS++ ++E
Sbjct: 110 KTQGHIRELEEEVQLLKNLSHPNIVRYLGT-VRESDSLNILMEFVPGGSISSLLEKF--- 165
Query: 696 SSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKL 755
G P EP I ++ GL++LH+ I+HRDIK N+L+D +G +++ DFG K+
Sbjct: 166 --GSFP--EPVIIMYTKQLLLGLEYLHNNGIMHRDIKGANILVDNKGCIRLADFGASKKV 221
Query: 756 TDKRSKRA--TMVGTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLN--EEPL 811
+ + +M GTPYWMAPEV+ Q + D+WS+G IEM +PP+ ++
Sbjct: 222 VELATVNGAKSMKGTPYWMAPEVILQTGHSFSADIWSVGCTVIEMATGKPPWSEQYQQFA 281
Query: 812 KALYLIATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSF 861
L++ T P + PE LS E K FL CL + R S ELL H F
Sbjct: 282 AVLHIGRTKAHPPI--PEDLSPEAKDFLMKCLHKEPSLRLSATELLQHPF 329
>Hs4505153 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 626
Score = 141 bits (355), Expect = 5e-33
Identities = 106/314 (33%), Positives = 152/314 (47%), Gaps = 43/314 (13%)
Query: 563 KPAMSNAEIMTNLKNVTFNMDPTPF-FRMVEKAGQGASGSVYLAERLQLPPYKDELEAEK 621
+ A S + +NV P +R + GQGA G VYL +
Sbjct: 336 RSADSENALSVQERNVPTKSPSAPINWRRGKLLGQGAFGRVYLCYDVDT----------- 384
Query: 622 NQLGNKVAIKQMIL---SKQPRKEL--IVNEILVMKDSKHNNIVNFLEAYL-KTEDDLWV 675
G ++A KQ+ S + KE+ + EI ++K+ +H IV + + E L +
Sbjct: 385 ---GRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLRDRAEKTLTI 441
Query: 676 VMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDN 735
MEYM GGS+ D ++ LTE R+ +G+ +LH I+HRDIK N
Sbjct: 442 FMEYMPGGSVKDQLK-------AYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGAN 494
Query: 736 VLLDTRGRVKITDFG-------FCAKLTDKRSKRATMVGTPYWMAPEVVKQREYDEKVDV 788
+L D+ G VK+ DFG C T RS + GTPYWM+PEV+ Y K DV
Sbjct: 495 ILRDSAGNVKLGDFGASKRLQTICMSGTGMRS----VTGTPYWMSPEVISGEGYGRKADV 550
Query: 789 WSLGIMTIEMLESEPPYLNEEPLKALYLIATNGT-PKLKHPEYLSLEIKRFLSVCLCVDV 847
WSLG +EML +PP+ E + A++ IAT T P+L P ++S + FL + V+
Sbjct: 551 WSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQL--PSHISEHGRDFLR-RIFVEA 607
Query: 848 KYRASTEELLHHSF 861
+ R S EELL H F
Sbjct: 608 RQRPSAEELLTHHF 621
>At1g53570 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 608
Score = 140 bits (353), Expect = 9e-33
Identities = 96/274 (35%), Positives = 142/274 (51%), Gaps = 32/274 (11%)
Query: 595 GQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQM--ILSKQPRKELIVN---EIL 649
G G G VYL +EK G AIK++ I Q KE + EI
Sbjct: 221 GSGTFGQVYLG-----------FNSEK---GKMCAIKEVKVISDDQTSKECLKQLNQEIN 266
Query: 650 VMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAY 709
++ H NIV + + L +E+ L V +EY+ GGS+ ++++ TEP I
Sbjct: 267 LLNQLCHPNIVQYYGSEL-SEETLSVYLEYVSGGSIHKLLKD-------YGSFTEPVIQN 318
Query: 710 IVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMVGTP 769
R+ GL +LH ++ +HRDIK N+L+D G +K+ DFG AK S + G+P
Sbjct: 319 YTRQILAGLAYLHGRNTVHRDIKGANILVDPNGEIKLADFGM-AKHVTAFSTMLSFKGSP 377
Query: 770 YWMAPEVV-KQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIA-TNGTPKLKH 827
YWMAPEVV Q Y VD+WSLG +EM S+PP+ E + A++ I + TP++
Sbjct: 378 YWMAPEVVMSQNGYTHAVDIWSLGCTILEMATSKPPWSQFEGVAAIFKIGNSKDTPEI-- 435
Query: 828 PEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSF 861
P++LS + K F+ +CL + R + +LL H F
Sbjct: 436 PDHLSNDAKNFIRLCLQRNPTVRPTASQLLEHPF 469
>YAR019c [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 974
Score = 139 bits (350), Expect = 2e-32
Identities = 95/294 (32%), Positives = 144/294 (48%), Gaps = 36/294 (12%)
Query: 579 TFNMDPTPFFRMVEKA---------GQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVA 629
T ++ TP R EK+ G+G+ G VY A + + D++ VA
Sbjct: 7 TDRVNLTPIQRASEKSVQYHLKQVIGRGSYGVVYKA----INKHTDQV----------VA 52
Query: 630 IKQMILSKQPRKELIVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDII 689
IK+++ I+ EI ++K+ HNNIV + +++ +L++++EY GSL +I
Sbjct: 53 IKEVVYENDEELNDIMAEISLLKNLNHNNIVKY-HGFIRKSYELYILLEYCANGSLRRLI 111
Query: 690 ENSPTGSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDF 749
S TG L+E + V +T GLK+LH + +IHRDIK+ N+LL VK+ DF
Sbjct: 112 SRSSTG------LSENESKTYVTQTLLGLKYLHGEGVIHRDIKAANILLSADNTVKLADF 165
Query: 750 GFCAKLTDKRSKRATMVGTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEE 809
G T S T+ GT WMAPE++ R D+WSLG +EML PPY N
Sbjct: 166 GVS---TIVNSSALTLAGTLNWMAPEILGNRGASTLSDIWSLGATVVEMLTKNPPYHNLT 222
Query: 810 PLKALYLIATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSFFN 863
Y + + P S +K FLS C ++ R + ++LL H + N
Sbjct: 223 DANIYYAVEND---TYYPPSSFSEPLKDFLSKCFVKNMYKRPTADQLLKHVWIN 273
>Hs22045241 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 122
Score = 139 bits (349), Expect = 2e-32
Identities = 67/111 (60%), Positives = 83/111 (74%)
Query: 765 MVGTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTPK 824
MVGTPYWMAPEVV ++ Y KVD+WSLGIM IEM+E EPPYLNE PL+ALYLIATNGTP+
Sbjct: 1 MVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPE 60
Query: 825 LKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSFFNMSCESQDLISLL 875
L++PE LS + FL+ CL +DV+ R S +ELL H F ++ L L+
Sbjct: 61 LQNPEKLSPIFRDFLNRCLEMDVEKRGSAKELLQHPFLKLAKPLSSLTPLI 111
>At1g09000 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 666
Score = 139 bits (349), Expect = 2e-32
Identities = 94/312 (30%), Positives = 160/312 (51%), Gaps = 39/312 (12%)
Query: 579 TFNMDPTPFFRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSK- 637
T +M P +R + G+GA G+VY+ L G +A+KQ++++
Sbjct: 60 TVDMAPPISWRKGQLIGRGAFGTVYMGMNLDS--------------GELLAVKQVLIAAN 105
Query: 638 -------QPRKELIVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIE 690
Q + + E+ ++K+ H NIV +L ++ +D L +++E++ GGS++ ++E
Sbjct: 106 FASKEKTQAHIQELEEEVKLLKNLSHPNIVRYLGT-VREDDTLNILLEFVPGGSISSLLE 164
Query: 691 NSPTGSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFG 750
P E + R+ GL++LH+ I+HRDIK N+L+D +G +K+ DFG
Sbjct: 165 KF-------GPFPESVVRTYTRQLLLGLEYLHNHAIMHRDIKGANILVDNKGCIKLADFG 217
Query: 751 FCAKLTDKRSKRA--TMVGTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNE 808
++ + + +M GTPYWMAPEV+ Q + D+WS+G IEM+ + P+ +
Sbjct: 218 ASKQVAELATMTGAKSMKGTPYWMAPEVILQTGHSFSADIWSVGCTVIEMVTGKAPWSQQ 277
Query: 809 -EPLKALYLIATNGT-PKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSFF---N 863
+ + A++ I T + P + P+ LS + K FL CL R + ELL H F +
Sbjct: 278 YKEVAAIFFIGTTKSHPPI--PDTLSSDAKDFLLKCLQEVPNLRPTASELLKHPFVMGKH 335
Query: 864 MSCESQDLISLL 875
S DL S+L
Sbjct: 336 KESASTDLGSVL 347
>7293247 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 575
Score = 137 bits (346), Expect = 6e-32
Identities = 91/279 (32%), Positives = 142/279 (50%), Gaps = 34/279 (12%)
Query: 485 SQNQPKPGMQPLIQVTTSQNKQPSPSQSAAQMAMRQHNQHPAGMPKVANAKLQPAREAPR 544
+ N G P + T+ Q +Q Q+ Q+ HP P + + A+ A R
Sbjct: 256 TNNGNSGGSYPPMYPTSHQQQQQQQQQAKQGGDQNQNPLHPHAHPHPHHHQ-HLAKSASR 314
Query: 545 VGDSN------QQKTTEVSKKKPSKPA----MSNAEIMTNLKNVTFNMDPTPFFRMVEKA 594
S+ Q+ + S +P +++ + L+ V DP K
Sbjct: 315 ASSSSGGASSAAQQASGASGGAAGQPKQDQRLTHEQFRAALQMVVSAGDPRENLDHFNKI 374
Query: 595 GQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKELIVNEILVMKDS 654
G+G++G+V +A G +VA+K+M L KQ R+EL+ NE+++M+D
Sbjct: 375 GEGSTGTVCIAT--------------DKSTGRQVAVKKMDLRKQQRRELLFNEVVIMRDY 420
Query: 655 KHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAYIVRET 714
H NIV ++L D+LWVVMEY+EGG+LTDI+ +S + E QIA + ++
Sbjct: 421 HHPNIVETYSSFL-VNDELWVVMEYLEGGALTDIVTHSR--------MDEEQIATVCKQC 471
Query: 715 CQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCA 753
+ L +LH + +IHRDIKSD++LL GRVK++DFGFCA
Sbjct: 472 LKALAYLHSQGVIHRDIKSDSILLAADGRVKLSDFGFCA 510
>HsM5729922 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 618
Score = 137 bits (344), Expect = 9e-32
Identities = 95/284 (33%), Positives = 145/284 (50%), Gaps = 34/284 (11%)
Query: 588 FRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMIL---SKQPRKEL- 643
+R+ + GQGA G VYL + G ++A+KQ+ S + KE+
Sbjct: 355 WRLGKLLGQGAFGRVYLCYDVDT--------------GRELAVKQVQFDPDSPETSKEVN 400
Query: 644 -IVNEILVMKDSKHNNIVNFLEAYLKTEDD-LWVVMEYMEGGSLTDIIENSPTGSSGQSP 701
+ EI ++K+ H IV + ++ L + MEYM GGS+ D ++
Sbjct: 401 ALECEIQLLKNFLHERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLK-------AYGA 453
Query: 702 LTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTD---K 758
LTE R+ +G+ +LH I+HRDIK N+L D+ G VK+ DFG +L
Sbjct: 454 LTENGTRKYTRQILEGVHYLHSNMILHRDIKGANILRDSTGNVKLGDFGASKRLQTICLS 513
Query: 759 RSKRATMVGTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIA 818
+ ++ GTPYWM+PEV+ + Y K D+WS+ +EML +PP+ E + A++ IA
Sbjct: 514 GTGMKSVTGTPYWMSPEVISGQGYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIA 573
Query: 819 TNGT-PKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSF 861
T T PKL P ++S + FL + V+ K R S +ELL H F
Sbjct: 574 TQPTNPKL--PPHVSDYTRDFLK-RIFVEAKLRPSADELLRHMF 614
>At4g08500 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 608
Score = 136 bits (342), Expect = 2e-31
Identities = 83/247 (33%), Positives = 135/247 (54%), Gaps = 25/247 (10%)
Query: 625 GNKVAIKQMILSKQPRK-----ELIVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEY 679
G+ A+K++ L Q + + + EI ++ +H NIV + K +L++ +E
Sbjct: 355 GDFFAVKEVSLLDQGSQAQECIQQLEGEIKLLSQLQHQNIVRY-RGTAKDGSNLYIFLEL 413
Query: 680 MEGGSLTDIIENSPTGSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLD 739
+ GSL + + + L + ++ R+ GLK+LHDK IHRDIK N+L+D
Sbjct: 414 VTQGSLLKLYQ--------RYQLRDSVVSLYTRQILDGLKYLHDKGFIHRDIKCANILVD 465
Query: 740 TRGRVKITDFGFC--AKLTDKRSKRATMVGTPYWMAPEVVKQRE---YDEKVDVWSLGIM 794
G VK+ DFG +K D +S + GTP+WMAPEV+ +++ Y D+WSLG
Sbjct: 466 ANGAVKLADFGLAKVSKFNDIKSCK----GTPFWMAPEVINRKDSDGYGSPADIWSLGCT 521
Query: 795 TIEMLESEPPYLNEEPLKALYLIATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTE 854
+EM + PY + EP++AL+ I P++ P+ LSL+ + F+ CL V+ + R +
Sbjct: 522 VLEMCTGQIPYSDLEPVQALFRIGRGTLPEV--PDTLSLDARLFILKCLKVNPEERPTAA 579
Query: 855 ELLHHSF 861
ELL+H F
Sbjct: 580 ELLNHPF 586
>At4g14480 [T] KOG0582 Ste20-like serine/threonine protein kinase
Length = 487
Score = 135 bits (340), Expect = 3e-31
Identities = 108/312 (34%), Positives = 152/312 (48%), Gaps = 51/312 (16%)
Query: 588 FRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRK-ELIVN 646
+ ++ K G G S SVY A + + N + VAIK + L + + +
Sbjct: 15 YEIICKIGVGVSASVYKAICIPM-----------NSM--VVAIKAIDLDQSRADFDSLRR 61
Query: 647 EILVMKDSKHNNIVNFLEAYLKTEDD--LWVVMEYMEGGSLTDIIENS-PTGSSGQSPLT 703
E M H NI+N AY D LWVVM +M GSL I+ +S P+G L
Sbjct: 62 ETKTMSLLSHPNILN---AYCSFTVDRCLWVVMPFMSCGSLHSIVSSSFPSG------LP 112
Query: 704 EPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKL-------- 755
E I+ ++ET + +LHD+ +HRDIK+ N+L+D+ G VK+ DFG A +
Sbjct: 113 ENCISVFLKETLNAISYLHDQGHLHRDIKAGNILVDSDGSVKLADFGVSASIYEPVTSSS 172
Query: 756 -TDKRSKRAT-MVGTPYWMAPEVVKQRE-YDEKVDVWSLGIMTIEMLESEPPYLNEEPLK 812
T S R T + GTPYWMAPEVV Y K D+WS GI +E+ PP + PLK
Sbjct: 173 GTTSSSLRLTDIAGTPYWMAPEVVHSHTGYGFKADIWSFGITALELAHGRPPLSHLPPLK 232
Query: 813 AL------------YLIATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHS 860
+L Y I T+G+ K K + S + + +CL D R S E+LL H
Sbjct: 233 SLLMKITKRFHFSDYEINTSGSSK-KGNKKFSKAFREMVGLCLEQDPTKRPSAEKLLKHP 291
Query: 861 FFNMSCESQDLI 872
FF +C+ D +
Sbjct: 292 FFK-NCKGLDFV 302
>At4g24100 [T] KOG0582 Ste20-like serine/threonine protein kinase
Length = 710
Score = 135 bits (339), Expect = 4e-31
Identities = 95/310 (30%), Positives = 149/310 (47%), Gaps = 35/310 (11%)
Query: 580 FNMDPTPFFRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSK-Q 638
F+M+P + +++E+ G GAS VY A + LP VAIK + L +
Sbjct: 26 FSMNPKDY-KLMEEIGHGASAVVYRA--IYLPT------------NEVVAIKCLDLDRCN 70
Query: 639 PRKELIVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSG 698
+ I E M H N++ ++ + LWVVM +M GS +++ + +
Sbjct: 71 SNLDDIRRESQTMSLIDHPNVIKSFCSF-SVDHSLWVVMPFMAQGSCLHLMKTAYSDG-- 127
Query: 699 QSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKL--- 755
E I +++ET + L +LH + IHRD+K+ N+LLD G +K+ DFG A L
Sbjct: 128 ---FEESAICCVLKETLKALDYLHRQGHIHRDVKAGNILLDDNGEIKLGDFGVSACLFDN 184
Query: 756 TDKRSKRATMVGTPYWMAPEVVKQ-REYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKAL 814
D++ R T VGTP WMAPEV++ Y+ K D+WS GI +E+ P+ P+K L
Sbjct: 185 GDRQRARNTFVGTPCWMAPEVLQPGNGYNSKADIWSFGITALELAHGHAPFSKYPPMKVL 244
Query: 815 YLIATNGTPKL---------KHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSFFNMS 865
+ N P L K + K +++CL D R + E+LL HS F +
Sbjct: 245 LMTIQNAPPGLDYDRDKKFSKRTFSCAQSFKEMVAMCLVKDQTKRPTAEKLLKHSCFKHT 304
Query: 866 CESQDLISLL 875
+ + +L
Sbjct: 305 KPPEQTVKIL 314
>Hs22065797 [T] KOG0577 Serine/threonine protein kinase
Length = 897
Score = 134 bits (337), Expect = 6e-31
Identities = 85/203 (41%), Positives = 114/203 (55%), Gaps = 15/203 (7%)
Query: 677 MEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNV 736
MEY G S +D++E + PL E +IA I QGL +LH +IHRDIK+ N+
Sbjct: 1 MEYCLG-SASDLLEVH------KKPLQEVEIAAITHGALQGLAYLHSHTMIHRDIKAGNI 53
Query: 737 LLDTRGRVKITDFGFCAKLTDKRSKRATMVGTPYWMAPEVV---KQREYDEKVDVWSLGI 793
LL G+VK+ DFG + + S VGTPYWMAPEV+ + +YD KVDVWSLGI
Sbjct: 54 LLTEPGQVKLADFGSASMASPANS----FVGTPYWMAPEVILAMDEGQYDGKVDVWSLGI 109
Query: 794 MTIEMLESEPPYLNEEPLKALYLIATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYRAST 853
IE+ E +PP N + ALY IA N +P L+ E+ S + F+ CL + R ++
Sbjct: 110 TCIELAERKPPLFNMNAMSALYHIAQNESPTLQSNEW-SDYFRNFVDSCLQKIPQDRPTS 168
Query: 854 EELLHHSFFNMSCESQDLISLLE 876
EELL H F LI L++
Sbjct: 169 EELLKHIFVLRERPETVLIDLIQ 191
>At4g12020_6 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 422
Score = 134 bits (336), Expect = 8e-31
Identities = 98/285 (34%), Positives = 145/285 (50%), Gaps = 45/285 (15%)
Query: 595 GQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRK-----ELIVNEIL 649
G+G+ GSVY + + A+ G+ A K++ L Q + + + I
Sbjct: 160 GRGSLGSVY-----------EGISAD----GDFFAFKEVSLLDQGSQAHEWIQQVEGGIA 204
Query: 650 VMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAY 709
++ +H NIV + K E +L++ +E + GSL + + + G S S T
Sbjct: 205 LLSQLQHQNIVRY-RGTTKDESNLYIFLELVTQGSLRKLYQRNQLGDSVVSLYT------ 257
Query: 710 IVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMVGTP 769
R+ GLK+LHDK IHR+IK NVL+D G VK+ DFG +K ++ TP
Sbjct: 258 --RQILDGLKYLHDKGFIHRNIKCANVLVDANGTVKLADFGL--------AKVMSLWRTP 307
Query: 770 Y--WMAPEVV-KQREYD---EKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTP 823
Y WMAPEV+ ++YD D+WSLG +EML + PY + E ALY I T P
Sbjct: 308 YWNWMAPEVILNPKDYDGYGTPADIWSLGCTVLEMLTGQIPYSDLEIGTALYNIGTGKLP 367
Query: 824 KLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSFFNMSCES 868
K+ P+ LSL+ + F+ CL V+ + R + ELL+H F NM S
Sbjct: 368 KI--PDILSLDARDFILTCLKVNPEERPTAAELLNHPFVNMPLPS 410
>At4g10730 [T] KOG0582 Ste20-like serine/threonine protein kinase
Length = 693
Score = 133 bits (334), Expect = 1e-30
Identities = 96/302 (31%), Positives = 147/302 (47%), Gaps = 37/302 (12%)
Query: 576 KNVTFNMDPTPFFRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMIL 635
K F+++P + +++E+ G GAS V+ A + LP VAIK + L
Sbjct: 16 KKKGFSVNPKDY-KLMEEVGYGASAVVHRA--IYLPT------------NEVVAIKSLDL 60
Query: 636 SK-QPRKELIVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENS-P 693
+ + I E M H N++ ++ + LWVVM +M GS +++ + P
Sbjct: 61 DRCNSNLDDIRREAQTMTLIDHPNVIKSFCSFA-VDHHLWVVMPFMAQGSCLHLMKAAYP 119
Query: 694 TGSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCA 753
G E I +++ET + L +LH + IHRD+K+ N+LLD G +K+ DFG A
Sbjct: 120 DG------FEEAAICSMLKETLKALDYLHRQGHIHRDVKAGNILLDDTGEIKLGDFGVSA 173
Query: 754 KL---TDKRSKRATMVGTPYWMAPEVVKQRE-YDEKVDVWSLGIMTIEMLESEPPYLNEE 809
L D++ R T VGTP WMAPEV++ Y+ K D+WS GI +E+ P+
Sbjct: 174 CLFDNGDRQRARNTFVGTPCWMAPEVLQPGSGYNSKADIWSFGITALELAHGHAPFSKYP 233
Query: 810 PLKALYLIATNGTPKL---------KHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHS 860
P+K L + N P L K + K +++CL D R + E+LL HS
Sbjct: 234 PMKVLLMTIQNAPPGLDYDRDKKFSKKMSSCAQSFKELVALCLVKDQTKRPTAEKLLKHS 293
Query: 861 FF 862
FF
Sbjct: 294 FF 295
>Hs21735556 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 620
Score = 132 bits (333), Expect = 2e-30
Identities = 94/284 (33%), Positives = 143/284 (50%), Gaps = 34/284 (11%)
Query: 588 FRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMIL---SKQPRKEL- 643
+R+ + GQGA G VYL + G ++A+KQ+ S + KE+
Sbjct: 357 WRLGKLLGQGAFGRVYLCYDVDT--------------GRELAVKQVQFDPDSPETSKEVN 402
Query: 644 -IVNEILVMKDSKHNNIVNFLEAYLKTEDD-LWVVMEYMEGGSLTDIIENSPTGSSGQSP 701
+ EI ++K+ H IV + ++ L + MEYM GGS+ D ++
Sbjct: 403 ALECEIQLLKNLLHERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLK-------AYGA 455
Query: 702 LTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTD---K 758
LTE R+ +G+ +LH I+ RDIK N+L D+ G VK+ DFG +L
Sbjct: 456 LTENVTRKYTRQILEGVHYLHSNMIVLRDIKGANILRDSTGNVKLGDFGASKRLQTICLS 515
Query: 759 RSKRATMVGTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIA 818
+ ++ GTPYWM+PEV+ Y K D+WS+ +EML +PP+ E + A++ IA
Sbjct: 516 GTGMKSVTGTPYWMSPEVISGEGYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIA 575
Query: 819 TNGT-PKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSF 861
T T PKL P ++S + FL + V+ K R S +ELL H F
Sbjct: 576 TQPTNPKL--PPHVSDYTRDFLK-RIFVEAKLRPSADELLRHMF 616
>At1g63700 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 883
Score = 130 bits (328), Expect = 7e-30
Identities = 89/307 (28%), Positives = 149/307 (47%), Gaps = 30/307 (9%)
Query: 561 PSKPAMSNAEIMTNLKNVTFNMDPTPFFRMVEKAGQGASGSVYLAERLQLPPYKDELEAE 620
P+ A ++ + + + P ++ G G+ G VYL
Sbjct: 373 PTYSAATSPSVPRSPARAEATVSPGSRWKKGRLLGMGSFGHVYLGFN------------- 419
Query: 621 KNQLGNKVAIKQMILSKQPRK-----ELIVNEILVMKDSKHNNIVNFLEAYLKTEDDLWV 675
++ G A+K++ L K + + EI V+ +H NIV + + +D L++
Sbjct: 420 -SESGEMCAMKEVTLCSDDPKSRESAQQLGQEISVLSRLRHQNIVQYYGSET-VDDKLYI 477
Query: 676 VMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDN 735
+EY+ GGS+ +++ G G++ + ++ GL +LH K+ +HRDIK N
Sbjct: 478 YLEYVSGGSIYKLLQEY--GQFGENAIRN-----YTQQILSGLAYLHAKNTVHRDIKGAN 530
Query: 736 VLLDTRGRVKITDFGFCAKLTDKRSKRATMVGTPYWMAPEVVKQREYDE-KVDVWSLGIM 794
+L+D GRVK+ DFG +T +S + G+PYWMAPEV+K VD+WSLG
Sbjct: 531 ILVDPHGRVKVADFGMAKHIT-AQSGPLSFKGSPYWMAPEVIKNSNGSNLAVDIWSLGCT 589
Query: 795 TIEMLESEPPYLNEEPLKALYLIATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTE 854
+EM ++PP+ E + A++ I N P++LS E K F+ CL + R +
Sbjct: 590 VLEMATTKPPWSQYEGVPAMFKIG-NSKELPDIPDHLSEEGKDFVRKCLQRNPANRPTAA 648
Query: 855 ELLHHSF 861
+LL H+F
Sbjct: 649 QLLDHAF 655
>YJL095w [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 1478
Score = 130 bits (327), Expect = 9e-30
Identities = 90/284 (31%), Positives = 145/284 (50%), Gaps = 37/284 (13%)
Query: 592 EKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRK--------EL 643
E G+G+ G+VYL + G +A+KQ+ + K + E
Sbjct: 1179 EMIGKGSFGAVYLCLNVTT--------------GEMMAVKQVEVPKYSSQNEAILSTVEA 1224
Query: 644 IVNEILVMKDSKHNNIVNFLEAYLKTEDDLW-VVMEYMEGGSLTDIIENSPTGSSGQSPL 702
+ +E+ +KD H NIV +L + +++++ + +EY+ GGS+ +I
Sbjct: 1225 LRSEVSTLKDLDHLNIVQYLG--FENKNNIYSLFLEYVAGGSVGSLIRM-------YGRF 1275
Query: 703 TEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKR 762
EP I ++ + +GL +LH K I+HRD+K+DN+LLD G KI+DFG K D S
Sbjct: 1276 DEPLIKHLTTQVLKGLAYLHSKGILHRDMKADNLLLDQDGICKISDFGISRKSKDIYSNS 1335
Query: 763 -ATMVGTPYWMAPEVVKQRE-YDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIA-T 819
TM GT +WMAPE+V ++ Y KVD+WSLG + +EM + P+ N E + A++ I +
Sbjct: 1336 DMTMRGTVFWMAPEMVDTKQGYSAKVDIWSLGCIVLEMFAGKRPWSNLEVVAAMFKIGKS 1395
Query: 820 NGTPKLKHP--EYLSLEIKRFLSVCLCVDVKYRASTEELLHHSF 861
P + +S + FL C ++ + R + ELL H F
Sbjct: 1396 KSAPPIPEDTLPLISQIGRNFLDACFEINPEKRPTANELLSHPF 1439
>SPAC23C11.16 [D] KOG0575 Polo-like serine/threonine protein kinase
Length = 683
Score = 130 bits (326), Expect = 1e-29
Identities = 84/316 (26%), Positives = 157/316 (49%), Gaps = 27/316 (8%)
Query: 550 QQKTTEVSKKKPSKPAMSNAEIMTNLKNVTFNMDPTPFFRMVEKAGQGASGSVYLAERLQ 609
++ T ++ KK SK + TNL N N+ F+ + G+G + +
Sbjct: 7 KEPKTAITPKKKSKASRLCFTPPTNLHNNKKNI----FYTRYDCIGEGGFARCFRVKDNY 62
Query: 610 LPPYKDELEAEKNQLGNKVAIKQMILSKQPRKELIVNEILVMKDSKHNNIVNFLEAYLKT 669
Y ++ A+++ +K +K + EI V + H NIV F++ + +
Sbjct: 63 GNIYAAKVIAKRSLQNDKTKLK------------LFGEIKVHQSMSHPNIVGFIDCF-ED 109
Query: 670 EDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHR 729
++++++E E SL +++ + LTEP++ Y++ + LK++H K +IHR
Sbjct: 110 STNIYLILELCEHKSLMELLRK-------RKQLTEPEVRYLMMQILGALKYMHKKRVIHR 162
Query: 730 DIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMVGTPYWMAPEVV--KQREYDEKVD 787
D+K N++LD VKI DFG A L D ++ T+ GTP ++APE++ + + +VD
Sbjct: 163 DLKLGNIMLDESNNVKIGDFGLAALLMDDEERKMTICGTPNYIAPEILFNSKEGHSFEVD 222
Query: 788 VWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTPKLKHPEYLSLEIKRFLSVCLCVDV 847
+WS G++ +L +PP+ ++E +K +Y + +S E K +S L D
Sbjct: 223 LWSAGVVMYALLIGKPPFQDKE-VKTIYRKIKANSYSFPSNVDISAEAKDLISSLLTHDP 281
Query: 848 KYRASTEELLHHSFFN 863
R S ++++ H FF+
Sbjct: 282 SIRPSIDDIVDHEFFH 297
>At4g29810 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 363
Score = 129 bits (325), Expect = 2e-29
Identities = 88/283 (31%), Positives = 145/283 (51%), Gaps = 32/283 (11%)
Query: 590 MVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILS-KQPRKELIVNEI 648
MV+ G+G+SG V L + G A+K + L+ + ++ I E+
Sbjct: 72 MVKVIGKGSSGVVQLVQH--------------KWTGQFFALKVIQLNIDEAIRKAIAQEL 117
Query: 649 LVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIA 708
+ + S+ N+V +++ + +++EYM+GGSL D +++ + + ++
Sbjct: 118 KINQSSQCPNLVTSYQSFYDN-GAISLILEYMDGGSLADFLKSVKA-------IPDSYLS 169
Query: 709 YIVRETCQGLKFLH-DKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMVG 767
I R+ QGL +LH D+HIIHRD+K N+L++ RG VKITDFG +T+ T VG
Sbjct: 170 AIFRQVLQGLIYLHHDRHIIHRDLKPSNLLINHRGEVKITDFGVSTVMTNTAGLANTFVG 229
Query: 768 TPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYL--NEEP-----LKALYLIATN 820
T +M+PE + +Y K D+WSLG++ +E + PY N+E + + I
Sbjct: 230 TYNYMSPERIVGNKYGNKSDIWSLGLVVLECATGKFPYAPPNQEETWTSVFELMEAIVDQ 289
Query: 821 GTPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSFFN 863
P L + S E+ F+S CL D R+S +EL+ H F N
Sbjct: 290 PPPALPSGNF-SPELSSFISTCLQKDPNSRSSAKELMEHPFLN 331
>At5g40440 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 520
Score = 129 bits (323), Expect = 3e-29
Identities = 76/238 (31%), Positives = 132/238 (54%), Gaps = 12/238 (5%)
Query: 628 VAIKQMILSKQPRKELIVNEILVMKDSK-HNNIVNFLEAYLKTED-DLWVVMEYMEGGSL 685
+A+K++ + ++ +++ ++ EI + ++ H +V+F A+ + + + +EYM GGSL
Sbjct: 109 LALKKINIFEREKRQQLLTEIRTLCEAPCHEGLVDFHGAFYSPDSGQISIALEYMNGGSL 168
Query: 686 TDIIENSPTGSSGQSPLTEPQIAYIVRETCQGLKFLHD-KHIIHRDIKSDNVLLDTRGRV 744
DI++ + + EP ++ + + QGL +LH +H++HRDIK N+L++ +G
Sbjct: 169 ADILKVT-------KKIPEPVLSSLFHKLLQGLSYLHGVRHLVHRDIKPANLLINLKGEP 221
Query: 745 KITDFGFCAKLTDKRSKRATMVGTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPP 804
KITDFG A L + + AT VGT +M+PE ++ Y D+WSLG+ E E P
Sbjct: 222 KITDFGISAGLENSMAMCATFVGTVTYMSPERIRNDSYSYPADIWSLGLALFECGTGEFP 281
Query: 805 YL-NEEPLKALYLIATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSF 861
Y+ NE P+ + I + +P E+ S E F+ CL D R + ++LL H F
Sbjct: 282 YIANEGPVNLMLQILDDPSPTPPKQEF-SPEFCSFIDACLQKDPDARPTADQLLSHPF 338
>At4g08470 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 560
Score = 127 bits (318), Expect = 1e-28
Identities = 97/338 (28%), Positives = 163/338 (47%), Gaps = 46/338 (13%)
Query: 536 LQPAREAPRVGDSNQQKTTEVSKKKPSKPAMSNAEIMTN--LKNVTFNMDPTPFFRMVEK 593
+ P+ E P D + + S++ PS ++M N ++N D T + + +
Sbjct: 253 MTPSMEFP---DRISFRKRDFSEEGPSGRVKEKRKLMRNKLIENFRKPEDITSWLKG-QL 308
Query: 594 AGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMIL-----SKQPRKELIVNEI 648
G+G+ SVY A ++ G+ A+K++ L Q + + EI
Sbjct: 309 LGRGSYASVYEAI---------------SEDGDFFAVKEVSLLDKGIQAQECIQQLEGEI 353
Query: 649 LVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIA 708
++ +H NIV + K L++ +E + GS+ + E + L+ ++
Sbjct: 354 ALLSQLQHQNIVRY-RGTAKDVSKLYIFLELVTQGSVQKLYE--------RYQLSYTVVS 404
Query: 709 YIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGF--CAKLTDKRSKRATMV 766
R+ GL +LHDK +HRDIK N+L+D G VK+ DFG +K D S +
Sbjct: 405 LYTRQILAGLNYLHDKGFVHRDIKCANMLVDANGTVKLADFGLAEASKFNDIMSCK---- 460
Query: 767 GTPYWMAPEVVKQREYD---EKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTP 823
GT +WMAPEV+ +++ D D+WSLG +EM + PY + +P++A + I P
Sbjct: 461 GTLFWMAPEVINRKDSDGNGSPADIWSLGCTVLEMCTGQIPYSDLKPIQAAFKIGRGTLP 520
Query: 824 KLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSF 861
+ P+ LSL+ + F+ CL V+ + R + ELLHH F
Sbjct: 521 DV--PDTLSLDARHFILTCLKVNPEERPTAAELLHHPF 556
>At4g08480 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 773
Score = 126 bits (317), Expect = 1e-28
Identities = 84/276 (30%), Positives = 144/276 (51%), Gaps = 40/276 (14%)
Query: 596 QGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRK-----ELIVNEILV 650
QG+ GSVY A ++ G+ A+K++ L Q + + + EI +
Sbjct: 509 QGSFGSVYEAI---------------SEDGDFFAVKEVSLLDQGSQAQECIQQLEGEIAL 553
Query: 651 MKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAYI 710
+ +H NI+ + K +L++ +E + GSL ++ + + + I+
Sbjct: 554 LSQLEHQNILRY-RGTDKDGSNLYIFLELVTQGSLLELYR--------RYQIRDSLISLY 604
Query: 711 VRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFC--AKLTDKRSKRATMVGT 768
++ GLK+LH K IHRDIK +L+D G VK+ DFG +KL D +S++ T+
Sbjct: 605 TKQILDGLKYLHHKGFIHRDIKCATILVDANGTVKLADFGLAKVSKLNDIKSRKETL--- 661
Query: 769 PYWMAPEVVKQRE---YDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTPKL 825
+WMAPEV+ +++ Y D+WSLG +EM + PY + EP++AL+ I P++
Sbjct: 662 -FWMAPEVINRKDNDGYRSPADIWSLGCTVLEMCTGQIPYSDLEPVEALFRIRRGTLPEV 720
Query: 826 KHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSF 861
P+ LSL+ + F+ CL ++ + R + ELL+H F
Sbjct: 721 --PDTLSLDARHFILKCLKLNPEERPTATELLNHPF 754
>At1g54960 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 585
Score = 126 bits (317), Expect = 1e-28
Identities = 87/307 (28%), Positives = 157/307 (50%), Gaps = 36/307 (11%)
Query: 563 KPAMSNAEIMTNLKNVTFNMDPTPFFRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKN 622
+ +M A+ + N T + P +R + G+GA G+VY+ L
Sbjct: 43 RKSMVFAKSQSPPNNSTVQIKPPIRWRKGQLIGRGAFGTVYMGMNLDS------------ 90
Query: 623 QLGNKVAIKQMILSK--------QPRKELIVNEILVMKDSKHNNIVNFLEAYLKTEDDLW 674
G +A+KQ++++ Q + + E+ ++K+ H NIV +L ++ ++ L
Sbjct: 91 --GELLAVKQVLITSNCASKEKTQAHIQELEEEVKLLKNLSHPNIVRYLGT-VREDETLN 147
Query: 675 VVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSD 734
+++E++ GGS++ ++E G P E + + GL++LH+ I+HRDIK
Sbjct: 148 ILLEFVPGGSISSLLEKF-----GAFP--ESVVRTYTNQLLLGLEYLHNHAIMHRDIKGA 200
Query: 735 NVLLDTRGRVKITDFGFCAKLTDKR--SKRATMVGTPYWMAPEVVKQREYDEKVDVWSLG 792
N+L+D +G +K+ DFG ++ + S +M GTPYWMAPEV+ Q + D+WS+G
Sbjct: 201 NILVDNQGCIKLADFGASKQVAELATISGAKSMKGTPYWMAPEVILQTGHSFSADIWSVG 260
Query: 793 IMTIEMLESEPPYLNE-EPLKALYLIATNGT-PKLKHPEYLSLEIKRFLSVCLCVDVKYR 850
IEM+ + P+ + + + A++ I T + P + P+ +S + FL CL + R
Sbjct: 261 CTVIEMVTGKAPWSQQYKEIAAIFHIGTTKSHPPI--PDNISSDANDFLLKCLQQEPNLR 318
Query: 851 ASTEELL 857
+ ELL
Sbjct: 319 PTASELL 325
>Hs4758016 [D] KOG0575 Polo-like serine/threonine protein kinase
Length = 607
Score = 126 bits (316), Expect = 2e-28
Identities = 84/268 (31%), Positives = 138/268 (51%), Gaps = 15/268 (5%)
Query: 599 SGSVYLAERLQ-LPPYKDELEAEKNQLGNKVAIK---QMILSKQPRKELIVNEILVMKDS 654
SG YL RL + EA + G+ A+K Q ++K ++E I+NEI + +D
Sbjct: 19 SGRTYLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDL 78
Query: 655 KHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAYIVRET 714
+H +IV F + + D++++ +E SL I + T L EP++ Y +R+
Sbjct: 79 QHRHIVRFSH-HFEDADNIYIFLELCSRKSLAHIWKARHT-------LLEPEVRYYLRQI 130
Query: 715 CQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMVGTPYWMAP 774
GLK+LH + I+HRD+K N + +K+ DFG A+L ++ T+ GTP ++AP
Sbjct: 131 LSGLKYLHQRGILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAP 190
Query: 775 EVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTPKLKHPEYLSLE 834
EV+ ++ + + DVWSLG + +L PP+ + LK Y L P LSL
Sbjct: 191 EVLLRQGHGPEADVWSLGCVMYTLLCGSPPFETAD-LKETYRCIKQVHYTL--PASLSLP 247
Query: 835 IKRFLSVCLCVDVKYRASTEELLHHSFF 862
++ L+ L + R S +++L H FF
Sbjct: 248 ARQLLAAILRASPRDRPSIDQILRHDFF 275
>At4g26890 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 444
Score = 126 bits (316), Expect = 2e-28
Identities = 91/250 (36%), Positives = 133/250 (52%), Gaps = 21/250 (8%)
Query: 625 GNKVAIKQMILSKQPRKELIVNEILVMKDSKHNNIVNFLEAYLKTEDDLWV---VMEYME 681
G A+K LS L+ E ++ ++V ++ L E + V +MEY+
Sbjct: 27 GELFAVKSADLSSS---SLLQKEQSILSTLSSPHMVKYIGTGLTRESNGLVYNILMEYVS 83
Query: 682 GGSLTDIIENSPTGSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTR 741
GG+L D+I+NS G+ P EP+I R+ GL +LH++ I+H D+KS NVL++
Sbjct: 84 GGNLHDLIKNS----GGKLP--EPEIRSYTRQILNGLVYLHERGIVHCDLKSHNVLVEEN 137
Query: 742 GRVKITDFGFCAKLTDKRSKRATMVGTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLES 801
G +KI D G CAK DK + GTP +MAPEV + E DVW+LG IEM+
Sbjct: 138 GVLKIADMG-CAKSVDK----SEFSGTPAFMAPEVARGEEQRFPADVWALGCTMIEMMTG 192
Query: 802 EPPYLN-EEPLKALYLIATNG-TPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHH 859
P+ + + A+Y I +G +P + P ++S + K FL CL D K R + EELL H
Sbjct: 193 SSPWPELNDVVAAMYKIGFSGESPAI--PAWISDKAKDFLKNCLKEDQKQRWTVEELLKH 250
Query: 860 SFFNMSCESQ 869
F + ESQ
Sbjct: 251 PFLDDDEESQ 260
>At5g66850 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 376
Score = 125 bits (315), Expect = 2e-28
Identities = 88/286 (30%), Positives = 135/286 (46%), Gaps = 38/286 (13%)
Query: 595 GQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKEL-----IVNEIL 649
G+G GSVY+A ++ G A+K++ L K + EI
Sbjct: 12 GRGTFGSVYVASN--------------SETGALCAMKEVELFPDDPKSAECIKQLEQEIK 57
Query: 650 VMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAY 709
++ + +H NIV + + ED ++ +EY+ GS+ I + +TE +
Sbjct: 58 LLSNLQHPNIVQYFGSET-VEDRFFIYLEYVHPGSINKYIRDHC------GTMTESVVRN 110
Query: 710 IVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMVGTP 769
R GL +LH+K +HRDIK N+L+D G VK+ DFG LT +R+ ++ G+P
Sbjct: 111 FTRHILSGLAYLHNKKTVHRDIKGANLLVDASGVVKLADFGMAKHLTGQRAD-LSLKGSP 169
Query: 770 YWMAPEVVKQREYDE--------KVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNG 821
YWMAPEV+ Q + VD+WSLG IEM +PP+ E A++ + +
Sbjct: 170 YWMAPEVLMQAVMQKDSNPDLAFAVDIWSLGCTIIEMFTGKPPWSEFEGAAAMFKVMRDS 229
Query: 822 TPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSFFNMSCE 867
P PE +S E K FL +C + R + LL H F S +
Sbjct: 230 PP---IPESMSPEGKDFLRLCFQRNPAERPTASMLLEHRFLKNSLQ 272
>Hs18552621 [R] KOG0597 Serine-threonine protein kinase FUSED
Length = 1315
Score = 125 bits (314), Expect = 3e-28
Identities = 84/276 (30%), Positives = 140/276 (50%), Gaps = 28/276 (10%)
Query: 588 FRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKEL--IV 645
+ ++E G+G+ G VY R Y ++ VA+K + + KEL +
Sbjct: 4 YHVLEMIGEGSFGRVYKGRR----KYSAQV----------VALKFIPKLGRSEKELRNLQ 49
Query: 646 NEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEP 705
EI +M+ +H NIV+ L+++ +T+ ++ VV +Y EG L I+E+ L E
Sbjct: 50 REIEIMRGLRHPNIVHMLDSF-ETDKEVVVVTDYAEG-ELFQILEDD-------GKLPED 100
Query: 706 QIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATM 765
Q+ I + L +LH I+HRD+K N+LL G +K+ DFGF ++ ++
Sbjct: 101 QVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTSI 160
Query: 766 VGTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTPKL 825
GTP +M+PE+V++R YD D+WS+G + E+ PP+ + + LI + +
Sbjct: 161 KGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYATSIFQLVSLILKD---PV 217
Query: 826 KHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSF 861
+ P +S K FL L D + R S +LL+H F
Sbjct: 218 RWPSTISPCFKNFLQGLLTKDPRQRLSWPDLLYHPF 253
>Hs5174547 [T] KOG4279 Serine/threonine protein kinase
Length = 1374
Score = 125 bits (313), Expect = 4e-28
Identities = 90/280 (32%), Positives = 140/280 (49%), Gaps = 26/280 (9%)
Query: 595 GQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKELIVNEILVMKDS 654
G+G G VY L NQ+ ++AIK++ + + EI + K
Sbjct: 687 GKGTYGIVYAGRDLS------------NQV--RIAIKEIPERDSRYSQPLHEEIALHKHL 732
Query: 655 KHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAYIVRET 714
KH NIV +L ++ + + + ME + GGSL+ ++ + G E I + ++
Sbjct: 733 KHKNIVQYLGSFSEN-GFIKIFMEQVPGGSLSALLRSK----WGPLKDNEQTIGFYTKQI 787
Query: 715 CQGLKFLHDKHIIHRDIKSDNVLLDT-RGRVKITDFGFCAKLTDKRSKRATMVGTPYWMA 773
+GLK+LHD I+HRDIK DNVL++T G +KI+DFG +L T GT +MA
Sbjct: 788 LEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMA 847
Query: 774 PEVVKQ--REYDEKVDVWSLGIMTIEMLESEPPYLN-EEPLKALYLIAT-NGTPKLKHPE 829
PE++ + R Y + D+WSLG IEM +PP+ EP A++ + P++ PE
Sbjct: 848 PEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEI--PE 905
Query: 830 YLSLEIKRFLSVCLCVDVKYRASTEELLHHSFFNMSCESQ 869
+S E K F+ C D RA +LL F +S + +
Sbjct: 906 SMSAEAKAFILKCFEPDPDKRACANDLLVDEFLKVSSKKK 945
>Hs5032091 [RT] KOG0598 Ribosomal protein S6 kinase and related proteins
Length = 431
Score = 124 bits (311), Expect = 6e-28
Identities = 78/257 (30%), Positives = 130/257 (50%), Gaps = 20/257 (7%)
Query: 549 NQQKTTEVSKKKPSKPAMSNAEIMTNLKNVTFNMDPTPFFRMVEKAGQGASGSVYLAERL 608
+Q + E+ PS P + +I NL + F ++ G+G+ G V LA
Sbjct: 61 SQPQEPELMNANPSPPPSPSQQI--NLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARH- 117
Query: 609 QLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKELIVNEILVMKDSKHNNIVNFLEAYLK 668
+AE+ KV K+ IL K+ K ++ +++K+ KH +V L +
Sbjct: 118 ---------KAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVG-LHFSFQ 167
Query: 669 TEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIH 728
T D L+ V++Y+ GG L ++ + EP+ + E L +LH +I++
Sbjct: 168 TADKLYFVLDYINGGELFYHLQR-------ERCFLEPRARFYAAEIASALGYLHSLNIVY 220
Query: 729 RDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMVGTPYWMAPEVVKQREYDEKVDV 788
RD+K +N+LLD++G + +TDFG C + + S +T GTP ++APEV+ ++ YD VD
Sbjct: 221 RDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDW 280
Query: 789 WSLGIMTIEMLESEPPY 805
W LG + EML PP+
Sbjct: 281 WCLGAVLYEMLYGLPPF 297
>Hs20149547 [T] KOG0603 Ribosomal protein S6 kinase
Length = 735
Score = 124 bits (311), Expect = 6e-28
Identities = 93/343 (27%), Positives = 158/343 (45%), Gaps = 28/343 (8%)
Query: 528 MPKVANAKLQPAREAPRVGDSNQQKTTEVSKKKPSKP--AMSNAEIMTNLKNVTFNMDPT 585
MP + P E + N Q + E + +PSK + I ++K + DP+
Sbjct: 1 MPLAQLKEPWPLMELVPLDPENGQTSGEEAGLQPSKDEGVLKEISITHHVKAGSEKADPS 60
Query: 586 PFFRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKELIV 645
F +++ GQG+ G V+L ++ P L A K + ++ + +K R
Sbjct: 61 -HFELLKVLGQGSFGKVFLVRKVTRPD-SGHLYAMKVLKKATLKVRDRVRTKMERD---- 114
Query: 646 NEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEP 705
++ D H +V A+ +TE L+++++++ GG L T S + TE
Sbjct: 115 ----ILADVNHPFVVKLHYAF-QTEGKLYLILDFLRGGDLF-------TRLSKEVMFTEE 162
Query: 706 QIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATM 765
+ + + E GL LH II+RD+K +N+LLD G +K+TDFG + D K +
Sbjct: 163 DVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSF 222
Query: 766 VGTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTPKL 825
GT +MAPEVV ++ + D WS G++ EML P+ ++ + + LI KL
Sbjct: 223 CGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLIL---KAKL 279
Query: 826 KHPEYLSLEIKRFLSVCLCVDVKYRAST-----EELLHHSFFN 863
P++LS E + L + R + EE+ H F++
Sbjct: 280 GMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYS 322
Score = 90.5 bits (223), Expect = 1e-17
Identities = 72/242 (29%), Positives = 121/242 (49%), Gaps = 25/242 (10%)
Query: 629 AIKQMILSKQPRKELIVNEILVMKDSKHNNIVNFLEAYLKTEDD---LWVVMEYMEGGSL 685
A+K + SK+ E I EIL ++ +H NI+ + Y DD +++V E M GG L
Sbjct: 445 AVKVIDKSKRDPSEEI--EIL-LRYGQHPNIITLKDVY----DDGKHVYLVTELMRGGEL 497
Query: 686 TDIIENSPTGSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVL-LDTRGR- 743
D I Q +E + ++++ + +++LH + ++HRD+K N+L +D G
Sbjct: 498 LDKILR-------QKFFSEREASFVLHTIGKTVEYLHSQGVVHRDLKPSNILYVDESGNP 550
Query: 744 --VKITDFGFCAKLTDKRSKRATMVGTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLES 801
++I DFGF +L + T T ++APEV+K++ YDE D+WSLGI+ ML
Sbjct: 551 ECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAG 610
Query: 802 EPPYLNEEPLKALYLIATNGTPKLK----HPEYLSLEIKRFLSVCLCVDVKYRASTEELL 857
P+ N ++ G+ K + +S K +S L VD R + +++L
Sbjct: 611 YTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDPHQRLTAKQVL 670
Query: 858 HH 859
H
Sbjct: 671 QH 672
>At1g70430 [T] KOG0582 Ste20-like serine/threonine protein kinase
Length = 594
Score = 123 bits (309), Expect = 1e-27
Identities = 92/294 (31%), Positives = 147/294 (49%), Gaps = 41/294 (13%)
Query: 588 FRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSK-QPRKELIVN 646
+ + E+ G+G S +VY A + L N++ VA+K + L K + E I
Sbjct: 16 YELFEEVGEGVSATVYRARCIAL-----------NEI---VAVKILDLEKCRNDLETIRK 61
Query: 647 EILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENS-PTGSSGQSPLTEP 705
E+ +M H N++ +++ + LW+VM YM GGS ++++ P G L +P
Sbjct: 62 EVHIMSLIDHPNLLKAHCSFIDSSS-LWIVMPYMSGGSCFHLMKSVYPEG------LEQP 114
Query: 706 QIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTD---KRSKR 762
IA ++RE + L +LH + IHRD+K+ N+L+ ++G VK+ DFG A + D + R
Sbjct: 115 IIATLLREVLKALVYLHRQGHIHRDVKAGNILIHSKGVVKLGDFGVSACMFDSGERMQTR 174
Query: 763 ATMVGTPYWMAPEVVKQRE-YDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNG 821
T VGTP WMAPEV++Q + YD K + P+ P+K L + N
Sbjct: 175 NTFVGTPCWMAPEVMQQLDGYDFKY-----------LAHGHAPFSKYPPMKVLLMTLQNA 223
Query: 822 TPKLKH--PEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSFFNMSCESQDLIS 873
P+L + + S + ++ CL D K R + +LL H FF S D +S
Sbjct: 224 PPRLDYDRDKKFSKSFRELIAACLVKDPKKRPTAAKLLKHPFFK-HARSTDYLS 276
>At3g61960 [OUT] KOG0595 Serine/threonine-protein kinase involved in autophagy
Length = 648
Score = 123 bits (308), Expect = 1e-27
Identities = 84/251 (33%), Positives = 133/251 (52%), Gaps = 19/251 (7%)
Query: 619 AEKNQLGNKVAIKQM---ILSKQPRKELIVNEILVMKDSKHNNIVNFLEAYLKTEDDLWV 675
A+ G +VA+K++ +LS + R L+ EI ++ H NI+ F EA ++T D +++
Sbjct: 27 AKHRSSGLEVAVKEIDKKLLSPKVRDNLL-KEISILSTIDHPNIIRFYEA-IETGDRIFL 84
Query: 676 VMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDN 735
V+EY GG L I G+ P E + +R+ GL+ L +KH IHRD+K N
Sbjct: 85 VLEYCSGGDLAGYINRH-----GKVP--EAVAKHFMRQLALGLQVLQEKHFIHRDLKPQN 137
Query: 736 VLLDTRG---RVKITDFGFCAKLTDKRSKRATMVGTPYWMAPEVVKQREYDEKVDVWSLG 792
+LL ++ +KI DFGF LT + S T G+P +MAPE+++ ++YD K D+WS G
Sbjct: 138 LLLSSKEVTPLLKIGDFGFARSLTPE-SMAETFCGSPLYMAPEIIRNQKYDAKADLWSAG 196
Query: 793 IMTIEMLESEPPYLNEEPLKALYLIATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYRAS 852
+ +++ +PP+ ++ + I + +LK PE EI V LC + R
Sbjct: 197 AILFQLVTGKPPFDGNNHIQLFHNIVRD--TELKFPEDTRNEIHPD-CVDLCRSLLRRNP 253
Query: 853 TEELLHHSFFN 863
E L FFN
Sbjct: 254 IERLTFREFFN 264
>7290841 [D] KOG0591 NIMA (never in mitosis)-related G2-specific
serine/threonine protein kinase
Length = 735
Score = 123 bits (308), Expect = 1e-27
Identities = 72/223 (32%), Positives = 118/223 (52%), Gaps = 10/223 (4%)
Query: 642 ELIVNEILVMKDSKHNNIVNFLEAYLKTE-DDLWVVMEYMEGGSLTDIIENSPTGSSGQS 700
+ +V+EI V++ +H NIV + + E +++VME GG L I++ + S +
Sbjct: 61 DALVSEISVLRQLQHPNIVQYYHHLVNREAKSVYIVMECCAGGDLAQIVQRA---RSQRQ 117
Query: 701 PLTEPQIAYIVRETCQGLKFLHDK----HIIHRDIKSDNVLLDTRGRVKITDFGFCAKLT 756
EP I ++ + C+ L+ H+K I+HRDIK N+ LD G K+ DFG L
Sbjct: 118 RFEEPYIWRVLFQLCRALQVCHNKIPNGTILHRDIKPANIFLDAAGNAKLGDFGLARMLR 177
Query: 757 DKRSKRATMVGTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYL 816
+S A+ VGTP++M+PE+VK R+YD K DVW++G + EM PP+ +
Sbjct: 178 RDQSFAASFVGTPHYMSPELVKGRKYDRKSDVWAVGCLVYEMCALRPPFRGRAFDQLSEK 237
Query: 817 IATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHH 859
IA ++ P S +++ ++ L VD + R E ++ H
Sbjct: 238 IAQGEFSRI--PAIYSTDLQEIIAFMLAVDHEQRPGIEVIIRH 278
>7300559 [T] KOG4279 Serine/threonine protein kinase
Length = 1310
Score = 122 bits (306), Expect = 2e-27
Identities = 86/271 (31%), Positives = 129/271 (46%), Gaps = 24/271 (8%)
Query: 595 GQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKELIVNEILVMKDS 654
G+G G+VY A Q ++AIK++ + + EI +
Sbjct: 586 GKGTYGTVYAAR--------------DKQTQVRIAIKEVPEKNSQDVQPLHEEIKLHSQL 631
Query: 655 KHNNIVNFLEAYLKTEDDLW-VVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAYIVRE 713
+H NIV +L + +E+ + + ME + GGSL+D++E G E +A+ ++
Sbjct: 632 RHRNIVRYLGSC--SENGFFKIFMEQVPGGSLSDLLETK----WGPLKDNESTMAFYSKQ 685
Query: 714 TCQGLKFLHDKHIIHRDIKSDNVLLDT-RGRVKITDFGFCAKLTDKRSKRATMVGTPYWM 772
+GLK+LH++ I+HRDIK DNVL++T G VKI+DFG +L T GT +M
Sbjct: 686 ILEGLKYLHEQDIVHRDIKGDNVLVNTYSGVVKISDFGTSKRLARINPMTETFTGTLQYM 745
Query: 773 APEVVKQ--REYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTPKLKHPEY 830
APEV+ Q R Y D+WS G +EM +PP++ A PE
Sbjct: 746 APEVIDQGVRGYGPAADIWSFGCTNVEMATGKPPFIELGSAHAAMFKVGFYKKHPNIPEE 805
Query: 831 LSLEIKRFLSVCLCVDVKYRASTEELLHHSF 861
LS K F+ C + V R S +LL F
Sbjct: 806 LSANAKNFILRCFAISVMDRPSASQLLEDPF 836
>At1g50230 [R] KOG0597 Serine-threonine protein kinase FUSED
Length = 269
Score = 122 bits (305), Expect = 3e-27
Identities = 78/276 (28%), Positives = 136/276 (49%), Gaps = 28/276 (10%)
Query: 588 FRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKEL--IV 645
+ ++E G+G+ G VY R G VA+K ++ + K++ +
Sbjct: 6 YHVIELVGEGSFGRVYKGRR--------------KYTGQTVAMKFIMKQGKTDKDIHSLR 51
Query: 646 NEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEP 705
EI +++ KH NI+ L+++ + + VV E+ +G L +I+E+ L E
Sbjct: 52 QEIEILRKLKHENIIEMLDSF-ENAREFCVVTEFAQG-ELFEILEDDKC-------LPEE 102
Query: 706 QIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATM 765
Q+ I ++ + L +LH IIHRD+K N+L+ VK+ DFGF ++ ++
Sbjct: 103 QVQAIAKQLVKALDYLHSNRIIHRDMKPQNILIGAGSVVKLCDFGFARAMSTNTVVLRSI 162
Query: 766 VGTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTPKL 825
GTP +MAPE+VK++ YD VD+WSLG++ E+ +PP+ + I + +
Sbjct: 163 KGTPLYMAPELVKEQPYDRTVDLWSLGVILYELYVGQPPFYTNSVYALIRHIVKD---PV 219
Query: 826 KHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSF 861
K+P+ +S + FL L + R + L H F
Sbjct: 220 KYPDEMSTYFESFLKGLLNKEPHSRLTWPALREHPF 255
>Hs20550407 [T] KOG0201 Serine/threonine protein kinase
Length = 112
Score = 121 bits (304), Expect = 4e-27
Identities = 60/120 (50%), Positives = 77/120 (64%), Gaps = 8/120 (6%)
Query: 677 MEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNV 736
MEY +GGS D++E PL E QI I+RE +GL +LH + IHR +K+ NV
Sbjct: 1 MEYPDGGSTLDLLE--------PGPLDETQIITILREILKGLDYLHSEKKIHRGVKAANV 52
Query: 737 LLDTRGRVKITDFGFCAKLTDKRSKRATMVGTPYWMAPEVVKQREYDEKVDVWSLGIMTI 796
LL VK+ DFG +L D ++KR T VGTP+W+APEV+KQ YD K D+WSLGI TI
Sbjct: 53 LLSEHCEVKLVDFGMAGQLADTQTKRNTFVGTPFWIAPEVIKQSAYDSKADIWSLGITTI 112
>CE18699 [T] KOG0694 Serine/threonine protein kinase
Length = 1018
Score = 121 bits (304), Expect = 4e-27
Identities = 104/382 (27%), Positives = 164/382 (42%), Gaps = 54/382 (14%)
Query: 482 SDRSQNQPKPGMQPLIQVTTSQNKQPSPSQSAAQMAMRQHNQHPAGMPKVANAKLQPARE 541
S SQ+QP +TS + +P+ S + + + H +AK + ARE
Sbjct: 560 SSSSQHQPGTSSSG---PSTSSSIASTPTPSTSNSLFDKVSNHLPSFNPRKSAKKREARE 616
Query: 542 APRVGD---------------------SNQQKTTEVSKKKPSKPAMSNAEIMTNLKNVTF 580
A V S Q++ V + + S A + ++++ F
Sbjct: 617 AAAVAPMTAAVAAVNLNAPSTSNSMQPSTQERNLVVDEFPTDRSGPSQAPPVPAVRHIDF 676
Query: 581 --NMDPTPF----FRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMI 634
+ D P FR++ G+G G V L++ N KV K I
Sbjct: 677 FASSDGAPLTVEQFRLISVLGRGHFGKVILSQH----------NPTSNYYALKVLKKGDI 726
Query: 635 LSKQPRKELIVNEIL--VMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENS 692
L + + L+V + + V ++H +VN L +T + ++ MEY GG L I +
Sbjct: 727 LGRDEVESLMVEKRIFEVSSRARHPFLVN-LNGCFQTNEHVFFCMEYSMGGDLMRHIHDD 785
Query: 693 PTGSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFC 752
E + + GL FLH +II+RDIK DN+LLD G VKI DFG C
Sbjct: 786 V--------FDEVRGCFYAACVVLGLDFLHKHNIIYRDIKLDNLLLDREGYVKIADFGLC 837
Query: 753 AKLTDKRSKRATMVGTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLK 812
+ K +T GTP ++APEV+ Y +D W LG++ EML EPP+ ++ +
Sbjct: 838 KENMGPFDKTSTFCGTPEFLAPEVLSDSSYTRAIDWWGLGVLIFEMLVGEPPFSGDDEEE 897
Query: 813 ALYLIATNGTPKLKHPEYLSLE 834
I + +++P YLS+E
Sbjct: 898 IFDSIISE---DVRYPRYLSVE 916
>At5g56580 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 356
Score = 121 bits (304), Expect = 4e-27
Identities = 78/237 (32%), Positives = 121/237 (50%), Gaps = 15/237 (6%)
Query: 632 QMILSKQPRKELIVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIEN 691
QM + ++ RK+++ + S+ ++V ++ +V+EYM+ GSL D+I
Sbjct: 102 QMNIQEEIRKQIVQELKINQASSQCPHVVVCYHSFYHN-GAFSLVLEYMDRGSLADVIRQ 160
Query: 692 SPTGSSGQSPLTEPQIAYIVRETCQGLKFLH-DKHIIHRDIKSDNVLLDTRGRVKITDFG 750
T + EP +A + ++ GL +LH ++H+IHRDIK N+L++ +G VKI+DFG
Sbjct: 161 VKT-------ILEPYLAVVCKQVLLGLVYLHNERHVIHRDIKPSNLLVNHKGEVKISDFG 213
Query: 751 FCAKLTDKRSKRATMVGTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEE- 809
A L +R T VGT +M+PE + YD D+WSLG+ +E PYL E
Sbjct: 214 VSASLASSMGQRDTFVGTYNYMSPERISGSTYDYSSDIWSLGMSVLECAIGRFPYLESED 273
Query: 810 ---PLKALYLIA--TNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSF 861
P L+A P + S E F+S C+ D RAS+ +LL H F
Sbjct: 274 QQNPPSFYELLAAIVENPPPTAPSDQFSPEFCSFVSACIQKDPPARASSLDLLSHPF 330
>YDL159w [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 515
Score = 121 bits (303), Expect = 5e-27
Identities = 112/377 (29%), Positives = 175/377 (45%), Gaps = 63/377 (16%)
Query: 501 TSQNKQPSPSQSAAQMAMRQHNQHPAGMPKVANAKLQPAREAPRVGDSNQQKTTEVSKKK 560
+S N PS Q + +A N+H +P + + L PA + K
Sbjct: 132 SSTNSTPSTIQGLSNIATPVENEHSISLPPLEES-LSPA----------------AADLK 174
Query: 561 PSKPAMSNAEIMTNLKNVTFNMDPTPFFRMVEKAGQGASGSVYLAERLQLPPYKDELEAE 620
+ SN + L+++ + K G G SG+V A L +P
Sbjct: 175 DTLSGTSNGNYI-QLQDLV----------QLGKIGAGNSGTVVKA--LHVPD-------- 213
Query: 621 KNQLGNKVAIKQMILSKQPRKELI---VNEILVMKDSK-HNNIVNFLEAYLKTE--DDLW 674
+K+ K+ I +Q +I V E+ ++K+ K H NI+ F AY +++
Sbjct: 214 -----SKIVAKKTIPVEQNNSTIINQLVRELSIVKNVKPHENIITFYGAYYNQHINNEII 268
Query: 675 VVMEYMEGGSLTDIIE------NSPTGSSGQSPLTEPQIAYIVRETCQGLKFLHDKH-II 727
++MEY + GSL I+ T SS ++ E I+ I GL L+ ++ II
Sbjct: 269 ILMEYSDCGSLDKILSVYKRFVQRGTVSSKKTWFNELTISKIAYGVLNGLDHLYRQYKII 328
Query: 728 HRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMVGTPYWMAPEVVKQREYDEKVD 787
HRDIK NVL++++G++K+ DFG KL + S T VGT +M+PE ++ Y K D
Sbjct: 329 HRDIKPSNVLINSKGQIKLCDFGVSKKLIN--SIADTFVGTSTYMSPERIQGNVYSIKGD 386
Query: 788 VWSLGIMTIEMLESEPPY--LNEEP---LKALYLIATNGTPKLKHPEYLSLEIKRFLSVC 842
VWSLG+M IE++ E P N+ P L L I +P+L S E+ F++ C
Sbjct: 387 VWSLGLMIIELVTGEFPLGGHNDTPDGILDLLQRIVNEPSPRLPKDRIYSKEMTDFVNRC 446
Query: 843 LCVDVKYRASTEELLHH 859
+ + R+S ELLHH
Sbjct: 447 CIKNERERSSIHELLHH 463
>Hs4502023 [T] KOG0690 Serine/threonine protein kinase
Length = 481
Score = 121 bits (303), Expect = 5e-27
Identities = 85/290 (29%), Positives = 141/290 (48%), Gaps = 28/290 (9%)
Query: 588 FRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKELIVNE 647
F ++ G+G G V L +A K+ K++I++K V E
Sbjct: 152 FDYLKLLGKGTFGKVILVRE----------KATGRYYAMKILRKEVIIAKDEVAHT-VTE 200
Query: 648 ILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQI 707
V+++++H + A+ +T D L VMEY GG L + S + TE +
Sbjct: 201 SRVLQNTRHPFLTALKYAF-QTHDRLCFVMEYANGGELFFHL-------SRERVFTEERA 252
Query: 708 AYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMVG 767
+ E L++LH + +++RDIK +N++LD G +KITDFG C + + T G
Sbjct: 253 RFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCG 312
Query: 768 TPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTPKLKH 827
TP ++APEV++ +Y VD W LG++ EM+ P+ N++ + LI +++
Sbjct: 313 TPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILME---EIRF 369
Query: 828 PEYLSLEIKRFLSVCLCVDVKYR-----ASTEELLHHSFFNMSCESQDLI 872
P LS E K L+ L D K R + +E++ H FF +S QD++
Sbjct: 370 PRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFF-LSINWQDVV 418
>7290147 [T] KOG0583 Serine/threonine protein kinase
Length = 291
Score = 121 bits (303), Expect = 5e-27
Identities = 81/242 (33%), Positives = 127/242 (52%), Gaps = 27/242 (11%)
Query: 589 RMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKEL--IVN 646
R V GQG G V+L + ++ + Q KV +K++I+ + P+ EL I
Sbjct: 9 RAVRVLGQGTFGRVFLCHQNEV----------RGQPERKVCVKRIIV-RNPKTELGLIKE 57
Query: 647 EILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQ 706
E+ ++ +H +IV FL ++ + +VMEY+ G+L D+I+ P+G+ G + + +
Sbjct: 58 EVYIISQLRHPHIVEFLRSFSHA-GTVNIVMEYVPNGTLRDVIQQLPSGTGG---VNQER 113
Query: 707 IAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMV 766
+ R+ GL++LH + +IHRDIK +N+LLD RVKI DFG +A M
Sbjct: 114 LMGYFRDMVVGLEYLHIRCVIHRDIKPENMLLDANDRVKIADFGIANVHAPSTQLQAGM- 172
Query: 767 GTPYWMAPEVV-KQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTPKL 825
GTP +MAPE + Q + D K DVWSLG++ E+ P+ + N TP L
Sbjct: 173 GTPMYMAPEAMSSQGKVDFKSDVWSLGLVLYELCLGRSPF--------AAFLDKNATPAL 224
Query: 826 KH 827
H
Sbjct: 225 LH 226
>YMR001c [D] KOG0575 Polo-like serine/threonine protein kinase
Length = 705
Score = 120 bits (301), Expect = 9e-27
Identities = 59/181 (32%), Positives = 109/181 (59%), Gaps = 11/181 (6%)
Query: 627 KVAIKQMILSKQPRKELIVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLT 686
K K I S++ RK+L+ +EI + K H NIV F++ + + + ++++++E GSL
Sbjct: 110 KTVAKASIKSEKTRKKLL-SEIQIHKSMSHPNIVQFIDCF-EDDSNVYILLEICPNGSLM 167
Query: 687 DIIENSPTGSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKI 746
++++ + LTEP++ + + C +K++H + +IHRD+K N+ D+ +KI
Sbjct: 168 ELLKR-------RKVLTEPEVRFFTTQICGAIKYMHSRRVIHRDLKLGNIFFDSNYNLKI 220
Query: 747 TDFGFCAKLTDKRSKRATMVGTPYWMAPEVV--KQREYDEKVDVWSLGIMTIEMLESEPP 804
DFG A L ++ ++ T+ GTP ++APEV+ K + +VD+WSLG+M +L +PP
Sbjct: 221 GDFGLAAVLANESERKYTICGTPNYIAPEVLMGKHSGHSFEVDIWSLGVMLYALLIGKPP 280
Query: 805 Y 805
+
Sbjct: 281 F 281
>7302860 [T] KOG0696 Serine/threonine protein kinase
Length = 679
Score = 120 bits (301), Expect = 9e-27
Identities = 92/283 (32%), Positives = 141/283 (49%), Gaps = 28/283 (9%)
Query: 558 KKKPS--KPAMSNAEIMTNLKNVTFNMDPTPFFRMVEKAGQGASGSVYLAERLQLPPYKD 615
K+KPS KP + ++ T+ + + T F ++ G+G+ G V LAER +
Sbjct: 319 KQKPSQKKPMVMRSDTNTHTSSKKDMIRATDF-NFIKVLGKGSFGKVLLAERKG----SE 373
Query: 616 ELEAEKNQLGNKVAIKQMILSKQPRKELIVNEILVMKDSKHNNIVNFLEAYLKTEDDLWV 675
EL A K +K+ ++ + E + E V+ + + L + +T D L+
Sbjct: 374 ELYAIK-------ILKKDVIIQDDDVECTMIEKRVLALGEKPPFLVQLHSCFQTMDRLFF 426
Query: 676 VMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDN 735
VMEY+ GG L I+ EP + E GL FLH K I++RD+K DN
Sbjct: 427 VMEYVNGGDLMFQIQQF-------GKFKEPVAVFYAAEIAAGLFFLHTKGILYRDLKLDN 479
Query: 736 VLLDTRGRVKITDFGFCAK--LTDKRSKRATMVGTPYWMAPEVVKQREYDEKVDVWSLGI 793
VLLD G VKI DFG C + + DK +K T GTP ++APE++ + Y + VD W+ G+
Sbjct: 480 VLLDADGHVKIADFGMCKENIVGDKTTK--TFCGTPDYIAPEIILYQPYGKSVDWWAYGV 537
Query: 794 MTIEMLESEPPYLNEEPLKALYLIATNGTPKLKHPEYLSLEIK 836
+ EML +PP+ E+ + L A + +P+ LS E K
Sbjct: 538 LLYEMLVGQPPFDGEDEEE---LFAAITDHNVSYPKSLSKEAK 577
>YJL164c [T] KOG0616 cAMP-dependent protein kinase catalytic subunit (PKA)
Length = 397
Score = 120 bits (300), Expect = 1e-26
Identities = 92/337 (27%), Positives = 156/337 (45%), Gaps = 39/337 (11%)
Query: 540 REAPRVGDSNQQKTTEV----SKKKPSKPAMS--NAEIMTNL---KNVTFNMDPTPFFRM 590
RE N+ K+ E +++KP +P ++ N E VT F++
Sbjct: 30 RETTATESGNESKSVEKEGGETQEKPKQPHVTYYNEEQYKQFIAQARVTVGSIVYKNFQI 89
Query: 591 VEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKELIVNEILV 650
+ G G+ G V+L Y KV +K+ I+ + + E +E L+
Sbjct: 90 LRTLGTGSFGRVHLIRSRHNGRY----------YAMKV-LKKEIVVRLKQVEHTNDERLM 138
Query: 651 MKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAYI 710
+ H I+ + + ++++M+Y+EGG L ++ S P +
Sbjct: 139 LSIVTHPFIIRMWGTFQDAQQ-IFMIMDYIEGGELFSLLRKSQR-------FPNPVAKFY 190
Query: 711 VRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMVGTPY 770
E C L++LH K II+RD+K +N+LLD G +KITDFGF + D T+ GTP
Sbjct: 191 AAEVCLALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFAKYVPD---VTYTLCGTPD 247
Query: 771 WMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTPKLKHPEY 830
++APEVV + Y++ +D WS GI+ EML P+ + +K I +L+ P +
Sbjct: 248 YIAPEVVSTKPYNKSIDWWSFGILIYEMLAGYTPFYDSNTMKTYEKIL---NAELRFPPF 304
Query: 831 LSLEIKRFLSVCLCVDVKYRA-----STEELLHHSFF 862
+ ++K LS + D+ R TE++ +H +F
Sbjct: 305 FNEDVKDLLSRLITRDLSQRLGNLQNGTEDVKNHPWF 341
>Hs4885549 [T] KOG0690 Serine/threonine protein kinase
Length = 479
Score = 120 bits (300), Expect = 1e-26
Identities = 83/281 (29%), Positives = 135/281 (47%), Gaps = 27/281 (9%)
Query: 588 FRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKELIVNE 647
F ++ G+G G V L +A K+ K++I++K + E
Sbjct: 148 FDYLKLLGKGTFGKVILVRE----------KASGKYYAMKILKKEVIIAKDEVAHTLT-E 196
Query: 648 ILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQI 707
V+K+++H + + L+ +T+D L VMEY+ GG L + S + +E +
Sbjct: 197 SRVLKNTRHPFLTS-LKYSFQTKDRLCFVMEYVNGGELFFHL-------SRERVFSEDRT 248
Query: 708 AYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMVG 767
+ E L +LH I++RD+K +N++LD G +KITDFG C + + T G
Sbjct: 249 RFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCG 308
Query: 768 TPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTPKLKH 827
TP ++APEV++ +Y VD W LG++ EM+ P+ N++ K LI +K
Sbjct: 309 TPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILME---DIKF 365
Query: 828 PEYLSLEIKRFLSVCLCVDVKYRA-----STEELLHHSFFN 863
P LS + K LS L D R +E++ HSFF+
Sbjct: 366 PRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFS 406
>Hs4507831 [OUT] KOG0595 Serine/threonine-protein kinase involved in autophagy
Length = 1050
Score = 120 bits (300), Expect = 1e-26
Identities = 80/256 (31%), Positives = 124/256 (48%), Gaps = 21/256 (8%)
Query: 620 EKNQLGNKVAIKQMILSKQPRKE-LIVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVME 678
EK+ L +VA+K + + + L+ EI ++K+ KH NIV + + + + +++VME
Sbjct: 37 EKHDL--EVAVKCINKKNLAKSQTLLGKEIKILKELKHENIVALYD-FQEMANSVYLVME 93
Query: 679 YMEGGSLTDIIENSPTGSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLL 738
Y GG L D + T L+E I +++ ++ LH K IIHRD+K N+LL
Sbjct: 94 YCNGGDLADYLHAMRT-------LSEDTIRLFLQQIAGAMRLLHSKGIIHRDLKPQNILL 146
Query: 739 DTRG---------RVKITDFGFCAKLTDKRSKRATMVGTPYWMAPEVVKQREYDEKVDVW 789
RVKI DFGF A+ AT+ G+P +MAPEV+ + YD K D+W
Sbjct: 147 SNPAGRRANPNSIRVKIADFGF-ARYLQSNMMAATLCGSPMYMAPEVIMSQHYDGKADLW 205
Query: 790 SLGIMTIEMLESEPPYLNEEPLKALYLIATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKY 849
S+G + + L + P+ P N T P S +++ L L + K
Sbjct: 206 SIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIPRETSAPLRQLLLALLQRNHKD 265
Query: 850 RASTEELLHHSFFNMS 865
R +E HH F + S
Sbjct: 266 RMDFDEFFHHPFLDAS 281
>Hs20127541 [RT] KOG0598 Ribosomal protein S6 kinase and related proteins
Length = 427
Score = 120 bits (300), Expect = 1e-26
Identities = 73/267 (27%), Positives = 134/267 (49%), Gaps = 20/267 (7%)
Query: 543 PRVGDSNQQKTTEVSKKKPSKPAMSNAEIMTNLKNVTFNMDPTPFFRMVEKAGQGASGSV 602
P + D + + + +P+ +N I + N PT F ++ G+G G V
Sbjct: 52 PELPDHCYRMNSSPAGTPSPQPSRANGNINLG-PSANPNAQPTDF-DFLKVIGKGNYGKV 109
Query: 603 YLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKELIVNEILVMKDSKHNNIVNF 662
LA+R +++ KV K+ IL K+ + ++ +++K+ +H +V
Sbjct: 110 LLAKR----------KSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGL 159
Query: 663 LEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAYIVRETCQGLKFLH 722
++ +T + L+ V++Y+ GG L ++ + EP+ + E + +LH
Sbjct: 160 RYSF-QTPEKLYFVLDYVNGGELFFHLQR-------ERRFLEPRARFYAAEVASAIGYLH 211
Query: 723 DKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMVGTPYWMAPEVVKQREY 782
+II+RD+K +N+LLD +G V +TDFG C + + +T GTP ++APEV+++ Y
Sbjct: 212 SLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPY 271
Query: 783 DEKVDVWSLGIMTIEMLESEPPYLNEE 809
D VD W LG + EML PP+ +++
Sbjct: 272 DRAVDWWCLGAVLYEMLHGLPPFYSQD 298
>At2g45490 [D] KOG0580 Serine/threonine protein kinase
Length = 288
Score = 120 bits (300), Expect = 1e-26
Identities = 85/289 (29%), Positives = 138/289 (47%), Gaps = 23/289 (7%)
Query: 588 FRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKELIVNE 647
F + G+G G VYLA + K + KV K+ I K + E
Sbjct: 22 FEIGRPLGKGKFGRVYLAREAK----------SKYIVALKVIFKEQI-EKYKIHHQLRRE 70
Query: 648 ILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQI 707
+ + +H NI+ L + + +++++EY GG L +++ + LTE Q
Sbjct: 71 MEIQTSLRHPNILR-LFGWFHDNERIFLILEYAHGGELYGVLKQN-------GHLTEQQA 122
Query: 708 AYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMVG 767
A + Q L + H K +IHRDIK +N+LLD GR+KI DFG+ + ++KR TM G
Sbjct: 123 ATYIASLSQALAYCHGKCVIHRDIKPENLLLDHEGRLKIADFGWSVQSSNKRK---TMCG 179
Query: 768 TPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTPKLKH 827
T ++APE+V+ R++D VD W+LGI+ E L PP+ E I
Sbjct: 180 TLDYLAPEMVENRDHDYAVDNWTLGILCYEFLYGNPPFEAESQKDTFKRILKIDLSFPLT 239
Query: 828 PEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSFFNMSCESQDLISLLE 876
P +S E K +S L D R S E+++ H + + + + + + ++
Sbjct: 240 PN-VSEEAKNLISQLLVKDPSKRLSIEKIMQHPWIVKNADPKGVCASID 287
>7301213 [R] KOG0589 Serine/threonine protein kinase
Length = 841
Score = 120 bits (300), Expect = 1e-26
Identities = 84/276 (30%), Positives = 143/276 (51%), Gaps = 32/276 (11%)
Query: 588 FRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSK--QPRKELIV 645
+ V GQG+ G L R G+++ KQ+ LS+ P ++L +
Sbjct: 105 YEKVRVVGQGSFGIAILYRR--------------KSDGHQIVFKQINLSELSPPGRDLAM 150
Query: 646 NEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEP 705
NE+ V H NIV++L +++K ++ L + MEY +GG+L II G+ E
Sbjct: 151 NEVDVFSKLHHPNIVSYLGSFIK-DNTLLIEMEYADGGTLAQIIAER----QGKLHFPER 205
Query: 706 QIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATM 765
I + + + ++H ++I+HRD+K+ NV L+ RG VKI DFG +K+ + + T+
Sbjct: 206 YIIAVFEQISSAINYMHSENILHRDLKTANVFLNRRGIVKIGDFGI-SKIMNTKIHAQTV 264
Query: 766 VGTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPY----LNEEPLKALYLIATNG 821
+GTPY+ +PE+ + +EYD K D+W+LG + EM + + L+E K ++A N
Sbjct: 265 LGTPYYFSPEMCEGKEYDNKSDIWALGCILGEMCCLKKTFAASNLSELVTK---IMAGNY 321
Query: 822 TPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELL 857
TP P + ++ +S L V+ R + E+L
Sbjct: 322 TPV---PSGYTSGLRSLMSNLLQVEAPRRPTASEVL 354
>Hs4826948 [T] KOG0616 cAMP-dependent protein kinase catalytic subunit (PKA)
Length = 358
Score = 119 bits (299), Expect = 2e-26
Identities = 84/281 (29%), Positives = 135/281 (47%), Gaps = 32/281 (11%)
Query: 588 FRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKV-AIKQMILSKQPRKELIVN 646
F + G G G V+L + + K+ KV +I +I KQ ++ + N
Sbjct: 49 FDTLATVGTGTFGRVHLVKE----------KTAKHFFALKVMSIPDVIRLKQ--EQHVHN 96
Query: 647 EILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQ 706
E V+K+ H ++ + E L+++MEY+ GG L + N SS
Sbjct: 97 EKSVLKEVSHPFLIRLFWTW-HDERFLYMLMEYVPGGELFSYLRNRGRFSSTTG------ 149
Query: 707 IAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMV 766
+ Y C +++LH K I++RD+K +N+LLD G +K+TDFGF KL D + T+
Sbjct: 150 LFYSAEIIC-AIEYLHSKEIVYRDLKPENILLDRDGHIKLTDFGFAKKLVD---RTWTLC 205
Query: 767 GTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTPKLK 826
GTP ++APEV++ + + VD W+LGI+ EML PP+ ++ P I K+
Sbjct: 206 GTPEYLAPEVIQSKGHGRAVDWWALGILIFEMLSGFPPFFDDNPFGIYQKILAG---KID 262
Query: 827 HPEYLSLEIKRFLSVCLCVDVKYRA-----STEELLHHSFF 862
P +L +K + L VD R ++ HH +F
Sbjct: 263 FPRHLDFHVKDLIKKLLVVDRTRRLGNMKNGANDVKHHRWF 303
>CE27177 [T] KOG4279 Serine/threonine protein kinase
Length = 1378
Score = 119 bits (299), Expect = 2e-26
Identities = 81/276 (29%), Positives = 137/276 (49%), Gaps = 31/276 (11%)
Query: 595 GQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKELIVNEILVMKDS 654
G+G G+VY A +++ ++ ++ +K++ + + ++ EI +
Sbjct: 671 GKGTYGTVYAAR---------DMDTQR-----QIVVKEIEVKYDEEVQPLMEEISLHSTL 716
Query: 655 KHNNIVNFLEAYLK----TEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAYI 710
H NIV +L L + D + ME++ GGSL+ ++ S P+ E + Y
Sbjct: 717 CHANIVQYLGCDLVGKDGSNDHFLIFMEHVPGGSLSSLLR------SKWGPMNENAMNYY 770
Query: 711 VRETCQGLKFLHDKHIIHRDIKSDNVLLDT-RGRVKITDFGFCAKLTDKRSKRATMVGTP 769
++ +GLK+LH+ I+HRDIK DNVL++T G KI+DFG C +L T GT
Sbjct: 771 GKQILEGLKYLHELKIVHRDIKGDNVLVNTYSGVCKISDFGTCKRLAGLNPVTETFTGTL 830
Query: 770 YWMAPEVVK--QREYDEKVDVWSLGIMTIEMLESEPPYLN-EEPLKALYLIATNGT-PKL 825
+MAPEV+ QR Y D+WS G +EM PP++ + P A++ + T P +
Sbjct: 831 QYMAPEVIDHGQRGYGAPADIWSFGCTMVEMATGRPPFVEMQNPQAAMFRVGMFKTHPPI 890
Query: 826 KHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSF 861
P ++ + + F+ C + R S ++LL F
Sbjct: 891 --PTEITEKCRNFIKSCFLPEACDRPSAKDLLQDPF 924
>CE02586 [T] KOG0696 Serine/threonine protein kinase
Length = 861
Score = 119 bits (299), Expect = 2e-26
Identities = 87/296 (29%), Positives = 138/296 (46%), Gaps = 25/296 (8%)
Query: 553 TTEVSKKKPSKPAMSNAEIMTNLKNVTFNMDPTPFFRMVEKAGQGASGSVYLAERLQLPP 612
T + S KP PA A + L + N+ F + G+G+ G V L E+
Sbjct: 379 TRDNSSSKPKDPAAPRASTLP-LGSSNHNVIKASDFNFLTVLGKGSFGKVLLGEQ----- 432
Query: 613 YKDELEAEKNQLGNKVAIKQMILSKQPRKELIVNEILVMKDSKHNNIVNFLEAYLKTEDD 672
+ K KV K +I+ E + E V+ + + + L + +T D
Sbjct: 433 -----KTTKELFAIKVLKKDVIIQDDD-VECTMTEKRVLALPEKPSFLVALHSCFQTMDR 486
Query: 673 LWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIK 732
L+ VME++ GG L I+ EP + E GL FLH K II+RD+K
Sbjct: 487 LYFVMEFVNGGDLMYQIQQV-------GKFKEPVAVFYAAEIAVGLFFLHSKGIIYRDLK 539
Query: 733 SDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMVGTPYWMAPEVVKQREYDEKVDVWSLG 792
DNV+L+ G +KITDFG C + + T GTP ++APE++ + Y + VD W+ G
Sbjct: 540 LDNVMLERDGHIKITDFGMCKENIFGDATTKTFCGTPDYIAPEIILYQPYGKSVDWWAYG 599
Query: 793 IMTIEMLESEPPYLNEEPLKALYLIATNGTPKLKHPEYLSLEIKRFLSVCLCVDVK 848
++ EML +PP+ E+ + I + + +P+ LS K +S+C + +K
Sbjct: 600 VLLFEMLAGQPPFDGEDEDELFTAITEH---NVSYPKSLS---KEAVSLCKALLIK 649
>7302464 [R] KOG0586 Serine/threonine protein kinase
Length = 739
Score = 119 bits (299), Expect = 2e-26
Identities = 107/388 (27%), Positives = 179/388 (45%), Gaps = 47/388 (12%)
Query: 501 TSQNKQPSPSQSA--AQMAMRQHNQHPAGM---PKVANAKLQPAREAPRVGDSNQQKTTE 555
T+ + S + SA A A+ H+ H G P V L P S ++ T
Sbjct: 68 TTDGARLSSNNSAVVASSAINHHHHHTPGSGVAPTVNKNVLSTHSAHP----SAIKQRTS 123
Query: 556 VSKKKPSKPAMSNAEIMTNLKNVTFNMDPTPFFRMVEKAGQGASGSVYLAERLQLPPYKD 615
+K P+ S+A + +++++ G+G V LA+ L
Sbjct: 124 SAKGSPNMQMRSSAPMRWRATEEHIGK-----YKLIKTIGKGNFAKVKLAKHLPT----- 173
Query: 616 ELEAEKNQLGNKVAIKQMILSKQPRK----ELIVNEILVMKDSKHNNIVNFLEAYLKTED 671
G +VAIK I+ K + + E+ +MK H NIV + ++TE
Sbjct: 174 ---------GKEVAIK--IIDKTQLNPGSLQKLFREVRIMKMLDHPNIVKLFQV-IETEK 221
Query: 672 DLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDI 731
L+++MEY GG + D + G+ E ++ + R+ +++ H K IIHRD+
Sbjct: 222 TLYLIMEYASGGEVFDYLV-----LHGRMKEKEARVKF--RQIVSAVQYCHQKRIIHRDL 274
Query: 732 KSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMVGTPYWMAPEVVKQREYD-EKVDVWS 790
K++N+LLD+ +KI DFGF + T SK T G+P + APE+ + ++YD +VDVWS
Sbjct: 275 KAENLLLDSELNIKIADFGFSNEFT-PGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWS 333
Query: 791 LGIMTIEMLESEPPYLNEEPLKALYLIATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYR 850
LG++ ++ P+ + L+ L G K + P Y+S + + L L ++ R
Sbjct: 334 LGVILYTLVSGSLPF-DGSTLRELRERVLRG--KYRIPFYMSTDCENLLRKFLVLNPAKR 390
Query: 851 ASTEELLHHSFFNMSCESQDLISLLEWK 878
AS E ++ + NM E +L +E K
Sbjct: 391 ASLETIMGDKWMNMGFEEDELKPYIEPK 418
>CE25046 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 348
Score = 119 bits (298), Expect = 2e-26
Identities = 80/275 (29%), Positives = 139/275 (50%), Gaps = 30/275 (10%)
Query: 595 GQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSK-QPRKELIVNEILVMKD 653
G GA V+LAE K+ G A+K + + ++E + NEI V++
Sbjct: 29 GTGAFSKVFLAE-------------SKSDAGQMYAVKCIDKKALKGKEESLENEIKVLRK 75
Query: 654 SKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAYIVRE 713
+HNNIV + Y + +++VME + GG L D I + TE + ++R+
Sbjct: 76 LRHNNIVQLFDTY-DEKQFVYLVMELVTGGELFDRIV-------AKGSYTEQDASNLIRQ 127
Query: 714 TCQGLKFLHDKHIIHRDIKSDNVLL---DTRGRVKITDFGFCAKLTDKRSKRATMVGTPY 770
+ + F+HD ++HRD+K +N+L D ++ I+DFG T+ AT GTP
Sbjct: 128 VLEAVGFMHDNGVVHRDLKPENLLYYNQDEDSKIMISDFGLSK--TEDSGVMATACGTPG 185
Query: 771 WMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTPKLKHP-- 828
++APEV++Q+ Y + VDVWS+G++ +L PP+ +E L+ G + P
Sbjct: 186 YVAPEVLQQKPYGKAVDVWSIGVIAYILLCGYPPFYDESDAN-LFAQIIKGEYEFDAPYW 244
Query: 829 EYLSLEIKRFLSVCLCVDVKYRASTEELLHHSFFN 863
+ +S K F++ +C D + R + ++ L H + +
Sbjct: 245 DQISDSAKDFITHLMCCDPEARFTCQDALSHPWIS 279
>YKL101w [D] KOG0588 Serine/threonine protein kinase
Length = 1518
Score = 117 bits (294), Expect = 6e-26
Identities = 102/387 (26%), Positives = 178/387 (45%), Gaps = 63/387 (16%)
Query: 503 QNKQPSPSQSAAQMAMRQHNQHPAGMPKVANAKLQPAREAPR---VGDSNQQKTTEVSKK 559
+ + S ++ AA+ AM + N +P +Q +A + DS T+ SK+
Sbjct: 13 KGRPSSLAKKAAKRAMAKVNSNPKRASGHLERVVQSVNDATKRLSQPDSTVSVATKSSKR 72
Query: 560 KPSKPAMSNAEIMTNLKNVTFNMDPTPFFRMVEKAGQGASGSVYLAERLQ---------- 609
K + D +++ + G+G+SG V LA+ ++
Sbjct: 73 K--------------------SRDTVGPWKLGKTLGKGSSGRVRLAKNMETGQLAAIKIV 112
Query: 610 --------------LPPYKDELEAEKNQLGNKVAIKQMILSKQPRKELIVNEILVMKDSK 655
+P N +A ++ Q I EI++MK
Sbjct: 113 PKKKAFVHCSNNGTVPNSYSSSMVTSNVSSPSIASREHSNHSQTNPYGIEREIVIMKLIS 172
Query: 656 HNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAYIVRETC 715
H N++ E + + + +L++V+EY++GG L D + S G+ P E + + ++
Sbjct: 173 HTNVMALFEVW-ENKSELYLVLEYVDGGELFDYLV-----SKGKLP--EREAIHYFKQIV 224
Query: 716 QGLKFLHDKHIIHRDIKSDNVLLDTRG-RVKITDFGFCA-KLTDKRSKRATMVGTPYWMA 773
+G+ + H +I HRD+K +N+LLD + R+KI DFG A +L +K K T G+P++ +
Sbjct: 225 EGVSYCHSFNICHRDLKPENLLLDKKNRRIKIADFGMAALELPNKLLK--TSCGSPHYAS 282
Query: 774 PEVVKQREY-DEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTPKLKHPEYLS 832
PE+V R Y DVWS GI+ +L P+ N++ +K L L +G K + P LS
Sbjct: 283 PEIVMGRPYHGGPSDVWSCGIVLFALLTGHLPF-NDDNIKKLLLKVQSG--KYQMPSNLS 339
Query: 833 LEIKRFLSVCLCVDVKYRASTEELLHH 859
E + +S L +D + R +T+E+L H
Sbjct: 340 SEARDLISKILVIDPEKRITTQEILKH 366
>Hs5453974 [T] KOG0694 Serine/threonine protein kinase
Length = 984
Score = 117 bits (294), Expect = 6e-26
Identities = 106/411 (25%), Positives = 178/411 (42%), Gaps = 58/411 (14%)
Query: 485 SQNQPKPGMQPLIQVTTSQNKQPSPSQSAAQMAMRQHNQHPAGMPKVAN-------AKLQ 537
S P P P++ V Q P+ + ++ + P P+ ++ ++L+
Sbjct: 535 SPQAPVPTTVPVVDVRIPQLAPPASDSTVTKLDFDLEPEPPPAPPRASSLGEIDESSELR 594
Query: 538 ----PAREAPRVGDSNQQKTTEVSKK----KPSKP-------AMSNAEIMTNLKNVTFNM 582
P +++ V D + + + K KP P + E + + FN+
Sbjct: 595 VLDIPGQDSETVFDIQNDRNSILPKSQSEYKPDTPQSGLEYSGIQELEDRRSQQRFQFNL 654
Query: 583 DPTPFFRMVEKAGQGASGSVYLAERLQLPPYKD--ELEAEKNQLGNKVAIKQMILSKQPR 640
FR G+G G V LAE YK+ E+ A K + + + S
Sbjct: 655 QD---FRCCAVLGRGHFGKVLLAE------YKNTNEMFAIKALKKGDIVARDEVDSLMCE 705
Query: 641 KELI--VNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSG 698
K + VN + +H +VN L A +T++ + VMEY GG L I
Sbjct: 706 KRIFETVNSV------RHPFLVN-LFACFQTKEHVCFVMEYAAGGDLMMHIHTDV----- 753
Query: 699 QSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDK 758
+EP+ + GL++LH+ I++RD+K DN+LLDT G VKI DFG C +
Sbjct: 754 ---FSEPRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGY 810
Query: 759 RSKRATMVGTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIA 818
+ +T GTP ++APEV+ + Y VD W LG++ EML E P+ ++ + I
Sbjct: 811 GDRTSTFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIV 870
Query: 819 TNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYR-----ASTEELLHHSFFNM 864
+ ++++P +LS E + L + + R E++ H FF +
Sbjct: 871 ND---EVRYPRFLSTEAISIMRRLLRRNPERRLGASEKDAEDVKKHPFFRL 918
>Hs4759050 [T] KOG0603 Ribosomal protein S6 kinase
Length = 740
Score = 117 bits (294), Expect = 6e-26
Identities = 93/333 (27%), Positives = 158/333 (46%), Gaps = 36/333 (10%)
Query: 537 QPAREAPRVGDSNQQKTTEVSKKKPSKPAMSNAEIMTNLKNVTFNMDPTPFFRMVEKAGQ 596
Q + P + +T EVS K+ + I ++K DP+ F +++ GQ
Sbjct: 26 QQIMDEPMGEEEINPQTEEVSIKEIA--------ITHHVKEGHEKADPSQF-ELLKVLGQ 76
Query: 597 GASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPR-KELIVNEILVMKDSK 655
G+ G V+L +++ ++ QL +K+ L + R + + +ILV +
Sbjct: 77 GSFGKVFLVKKIS--------GSDARQLYAMKVLKKATLKVRDRVRTKMERDILV--EVN 126
Query: 656 HNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAYIVRETC 715
H IV A+ +TE L+++++++ GG L T S + TE + + + E
Sbjct: 127 HPFIVKLHYAF-QTEGKLYLILDFLRGGDLF-------TRLSKEVMFTEEDVKFYLAELA 178
Query: 716 QGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMVGTPYWMAPE 775
L LH II+RD+K +N+LLD G +K+TDFG + D K + GT +MAPE
Sbjct: 179 LALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPE 238
Query: 776 VVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTPKLKHPEYLSLEI 835
VV +R + + D WS G++ EML P+ ++ + + +I KL P++LS E
Sbjct: 239 VVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMIL---KAKLGMPQFLSPEA 295
Query: 836 KRFLSVCLCVDVKYRA-----STEELLHHSFFN 863
+ L + + R EE+ HSFF+
Sbjct: 296 QSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFS 328
Score = 85.9 bits (211), Expect = 3e-16
Identities = 69/237 (29%), Positives = 114/237 (47%), Gaps = 23/237 (9%)
Query: 634 ILSKQPRKELIVNEILVMKDSKHNNIVNFLEAYLKTEDD---LWVVMEYMEGGSLTDIIE 690
I+ K R EIL ++ +H NI+ + Y DD ++VV E M+GG L D I
Sbjct: 452 IIDKSKRDPTEEIEIL-LRYGQHPNIITLKDVY----DDGKYVYVVTELMKGGELLDKIL 506
Query: 691 NSPTGSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVL-LDTRGR---VKI 746
Q +E + + ++ + +++LH + ++HRD+K N+L +D G ++I
Sbjct: 507 R-------QKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRI 559
Query: 747 TDFGFCAKLTDKRSKRATMVGTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYL 806
DFGF +L + T T ++APEV+K++ YD D+WSLG++ ML P+
Sbjct: 560 CDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFA 619
Query: 807 NEEPLKALYLIATNGTPKLK----HPEYLSLEIKRFLSVCLCVDVKYRASTEELLHH 859
N ++A G+ K + +S K +S L VD R + +L H
Sbjct: 620 NGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRH 676
>Hs13899225 [R] KOG0586 Serine/threonine protein kinase
Length = 688
Score = 117 bits (293), Expect = 8e-26
Identities = 84/287 (29%), Positives = 144/287 (49%), Gaps = 29/287 (10%)
Query: 588 FRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKEL--IV 645
+R++ G+G S V LA + G +VAIK + ++ L +
Sbjct: 59 YRLLRTIGKGNSAKVKLARHILT--------------GREVAIKIIDKTQLNPSSLQKLF 104
Query: 646 NEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEP 705
E+ +MK H NIV E ++TE L++VMEY G + D + S G+ E
Sbjct: 105 REVRIMKGLNHPNIVKLFEV-IETEKTLYLVMEYASAGEVFDYLV-----SHGRMKEKEA 158
Query: 706 QIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATM 765
+ + R+ + + H K+I+HRD+K++N+LLD +KI DFGF + T SK T
Sbjct: 159 RAKF--RQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFT-LGSKLDTF 215
Query: 766 VGTPYWMAPEVVKQREYD-EKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTPK 824
G+P + APE+ + ++YD +VD+WSLG++ ++ P+ + LK L G K
Sbjct: 216 CGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPF-DGHNLKELRERVLRG--K 272
Query: 825 LKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSFFNMSCESQDL 871
+ P Y+S + + L L ++ R + E+++ + N+ E ++L
Sbjct: 273 YRVPFYMSTDCESILRRFLVLNPAKRCTLEQIMKDKWINIGYEGEEL 319
>Hs13384594 [T] KOG0696 Serine/threonine protein kinase
Length = 697
Score = 117 bits (293), Expect = 8e-26
Identities = 83/257 (32%), Positives = 123/257 (47%), Gaps = 27/257 (10%)
Query: 562 SKPAMSNAEIMTNLKNVTFNMDPTPF----FRMVEKAGQGASGSVYLAERLQLPPYKDEL 617
S P S + T+ K F P F + G+G+ G V LAER DEL
Sbjct: 321 SSPIPSPSPSPTDPKRCFFGASPGRLHISDFSFLMVLGKGSFGKVMLAERRG----SDEL 376
Query: 618 EAEKNQLGNKVAIKQMILSKQPRKE--LIVNEILVMKDSKHNNIVNFL---EAYLKTEDD 672
A K +K+ ++ + + L+ +L + +FL + +T D
Sbjct: 377 YAIK-------ILKKDVIVQDDDVDCTLVEKRVLALGGRGPGGRPHFLTQLHSTFQTPDR 429
Query: 673 LWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIK 732
L+ VMEY+ GG L I+ EP A+ E GL FLH++ II+RD+K
Sbjct: 430 LYFVMEYVTGGDLMYHIQQL-------GKFKEPHAAFYAAEIAIGLFFLHNQGIIYRDLK 482
Query: 733 SDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMVGTPYWMAPEVVKQREYDEKVDVWSLG 792
DNV+LD G +KITDFG C + + T GTP ++APE++ + Y + VD WS G
Sbjct: 483 LDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTPDYIAPEIIAYQPYGKSVDWWSFG 542
Query: 793 IMTIEMLESEPPYLNEE 809
++ EML +PP+ E+
Sbjct: 543 VLLYEMLAGQPPFDGED 559
>CE24516 [OUT] KOG0595 Serine/threonine-protein kinase involved in autophagy
Length = 856
Score = 117 bits (293), Expect = 8e-26
Identities = 80/248 (32%), Positives = 125/248 (50%), Gaps = 28/248 (11%)
Query: 629 AIKQMILSKQPRKELIVNEILVMKDS---KHNNIVNFLEAYLKTEDDLWVVMEYMEGGSL 685
AI + +SK K L+ EI ++K+ KH N+V L+ +T +++VME+ GG L
Sbjct: 40 AIAKKNISKS--KNLLTKEIKILKELSSLKHENLVGLLKC-TETPTHVYLVMEFCNGGDL 96
Query: 686 TDIIENSPTGSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGR-- 743
D ++ T L E I + V + L+ ++ K I+HRD+K N+LL R
Sbjct: 97 ADYLQQKTT-------LNEDTIQHFVVQIAHALEAINKKGIVHRDLKPQNILLCNNSRTQ 149
Query: 744 --------VKITDFGFCAKLTDKRSKRATMVGTPYWMAPEVVKQREYDEKVDVWSLGIMT 795
+K+ DFGF L D AT+ G+P +MAPEV+ +YD K D+WS+G +
Sbjct: 150 NPHFTDIVIKLADFGFARFLNDG-VMAATLCGSPMYMAPEVIMSMQYDAKADLWSIGTIL 208
Query: 796 IEMLESEPPYLNEEP--LKALYLIATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYRAST 853
+ L + P++ + P LKA Y P + PE+ S ++ L L + K R S
Sbjct: 209 FQCLTGKAPFVAQTPPQLKAYYEKTRELRPNI--PEWCSPNLRDLLLRLLKRNAKDRISF 266
Query: 854 EELLHHSF 861
E+ +H F
Sbjct: 267 EDFFNHPF 274
>7303915 [T] KOG0694 Serine/threonine protein kinase
Length = 590
Score = 117 bits (293), Expect = 8e-26
Identities = 102/380 (26%), Positives = 160/380 (41%), Gaps = 40/380 (10%)
Query: 473 PRMHPQRIASDRSQ--NQPKPGMQPLIQVTTSQNKQPSPSQSAAQMAMRQHNQHPAGMPK 530
P++ + S + Q Q P +Q T N + + Q A RQ Q P P
Sbjct: 132 PQLGKLYVGSSQQQYAQQSSPIIQEPATPTIYGNSAAAGAPQFPQPAQRQEKQPPQQQPI 191
Query: 531 VANA-KLQPAREAPRVG----------DSNQQKTTEVSKKKPSKPAMSNAEIMTNLKNV- 578
AN +L A+ A +SNQQ+ + + + T
Sbjct: 192 YANQYELNVAKAAAAASVYSPSSSTTSNSNQQQQQQRRNVARGLQYRESGGLETGRAGKQ 251
Query: 579 --TFNMDPTPFFRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILS 636
M FR++ G+G G V L++ L + K K I++
Sbjct: 252 PPNAGMLSMDNFRLLSVLGRGHFGKVILSQ----------LRSNNQYYAIKALKKGDIIA 301
Query: 637 KQPRKELIVNEIL--VMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPT 694
+ + L+ + + V +H +VN + +TE + VMEY GG L I
Sbjct: 302 RDEVESLLSEKRIFEVANAMRHPFLVNLYSCF-QTEQHVCFVMEYAAGGDLMMHIHTDV- 359
Query: 695 GSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAK 754
EP+ + GL++LH+ II+RD+K DN+LLDT G VKI DFG C +
Sbjct: 360 -------FLEPRAVFYAACVVLGLQYLHENKIIYRDLKLDNLLLDTEGYVKIADFGLCKE 412
Query: 755 LTDKRSKRATMVGTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKAL 814
+ T GTP ++APEV+ + Y VD W LG++ EML E P+ ++ +
Sbjct: 413 GMGFGDRTGTFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIFEMLVGESPFPGDDEEEVF 472
Query: 815 YLIATNGTPKLKHPEYLSLE 834
I + ++++P +LSLE
Sbjct: 473 DSIVND---EVRYPRFLSLE 489
>7303914 [T] KOG0694 Serine/threonine protein kinase
Length = 1284
Score = 117 bits (293), Expect = 8e-26
Identities = 102/380 (26%), Positives = 160/380 (41%), Gaps = 40/380 (10%)
Query: 473 PRMHPQRIASDRSQ--NQPKPGMQPLIQVTTSQNKQPSPSQSAAQMAMRQHNQHPAGMPK 530
P++ + S + Q Q P +Q T N + + Q A RQ Q P P
Sbjct: 826 PQLGKLYVGSSQQQYAQQSSPIIQEPATPTIYGNSAAAGAPQFPQPAQRQEKQPPQQQPI 885
Query: 531 VANA-KLQPAREAPRVG----------DSNQQKTTEVSKKKPSKPAMSNAEIMTNLKNV- 578
AN +L A+ A +SNQQ+ + + + T
Sbjct: 886 YANQYELNVAKAAAAASVYSPSSSTTSNSNQQQQQQRRNVARGLQYRESGGLETGRAGKQ 945
Query: 579 --TFNMDPTPFFRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILS 636
M FR++ G+G G V L++ L + K K I++
Sbjct: 946 PPNAGMLSMDNFRLLSVLGRGHFGKVILSQ----------LRSNNQYYAIKALKKGDIIA 995
Query: 637 KQPRKELIVNEIL--VMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPT 694
+ + L+ + + V +H +VN + +TE + VMEY GG L I
Sbjct: 996 RDEVESLLSEKRIFEVANAMRHPFLVNLYSCF-QTEQHVCFVMEYAAGGDLMMHIHTDV- 1053
Query: 695 GSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAK 754
EP+ + GL++LH+ II+RD+K DN+LLDT G VKI DFG C +
Sbjct: 1054 -------FLEPRAVFYAACVVLGLQYLHENKIIYRDLKLDNLLLDTEGYVKIADFGLCKE 1106
Query: 755 LTDKRSKRATMVGTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKAL 814
+ T GTP ++APEV+ + Y VD W LG++ EML E P+ ++ +
Sbjct: 1107 GMGFGDRTGTFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIFEMLVGESPFPGDDEEEVF 1166
Query: 815 YLIATNGTPKLKHPEYLSLE 834
I + ++++P +LSLE
Sbjct: 1167 DSIVND---EVRYPRFLSLE 1183
>7299536 [D] KOG0580 Serine/threonine protein kinase
Length = 411
Score = 117 bits (293), Expect = 8e-26
Identities = 96/383 (25%), Positives = 176/383 (45%), Gaps = 52/383 (13%)
Query: 480 IASDRSQNQPKPGMQPLIQVTTSQNKQPSPSQSAAQMAMRQHNQHPAGMPKVANAKLQPA 539
IAS N KP M P ++ TTS+ P+P +++ P A+++
Sbjct: 70 IASSEGNNFQKP-MVPSVKKTTSEFAAPAPVAP-----IKKPESLSKQKPTAASSESSKE 123
Query: 540 REAPRVGDSNQQKTTEVSKKKPSKPAMSNAEIMTNLKNVTFNMDPTPFFRMVEKAGQGAS 599
A ++ TE +KP K T+ ++ R++ G+G
Sbjct: 124 LGAASSSAEKEKTKTETQPQKPKK---------------TWELNNFDIGRLL---GRGKF 165
Query: 600 GSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKELIVNEILVMKDSKHNNI 659
G+VYLA + + + KV K+ I + + EI + +H +I
Sbjct: 166 GNVYLAREKE----------SQFVVALKVLFKRQIGESNVEHQ-VRREIEIQSHLRHPHI 214
Query: 660 VNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAYIVRETCQGLK 719
+ L AY + +++++EY G+L + ++ P E Q A ++ C L
Sbjct: 215 LR-LYAYFHDDVRIYLILEYAPQGTLFNALQAQP-----MKRFDERQSATYIQALCSALL 268
Query: 720 FLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMVGTPYWMAPEVVKQ 779
+LH++ IIHRDIK +N+LL +G +KI DFG+ + + S R T+ GT ++ PE+V+
Sbjct: 269 YLHERDIIHRDIKPENLLLGHKGVLKIADFGW--SVHEPNSMRMTLCGTVDYLPPEMVQG 326
Query: 780 REYDEKVDVWSLGIMTIEMLESEPPYLN---EEPLKALYLIATNGTPKLKHPEYLSLEIK 836
+ + + VD+WSLG++ E+L P+ + +E K + + K PE++S
Sbjct: 327 KPHTKNVDLWSLGVLCFELLVGHAPFYSKNYDETYKKILKV------DYKLPEHISKAAS 380
Query: 837 RFLSVCLCVDVKYRASTEELLHH 859
+S L ++ ++R ++++ H
Sbjct: 381 HLISKLLVLNPQHRLPLDQVMVH 403
>SPBC12D12.04c [T] KOG0694 Serine/threonine protein kinase
Length = 1016
Score = 117 bits (292), Expect = 1e-25
Identities = 101/409 (24%), Positives = 176/409 (42%), Gaps = 43/409 (10%)
Query: 476 HPQRIASDRSQNQPKPGMQPLIQVTTSQNKQPSPSQ----SAAQMAMRQHNQHP--AGMP 529
H S S ++ K + + +TT+ +P+ S +A+ + P AG
Sbjct: 557 HHHHKKSKSSSSKHKENDKASVSITTTTTPSITPADPVPTSPKPLAIEPVKRKPVHAGNL 616
Query: 530 KVANAKLQPAREAPRVGDSNQQKTTEVSKKKPSKPAMSNAEIMTNLKNVTFNMDPT---- 585
+V + +V + + K PS A+ + +++ D T
Sbjct: 617 EVTSVSDNKLGATVQVVEQKVDDKADALTKPPSLDAVKEPIPVPSVETSVVAQDLTHKAK 676
Query: 586 ----PFFRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRK 641
F + G+G G V LAE L++EK KV K+ IL +
Sbjct: 677 RIGLEDFTFLSVLGKGNFGKVMLAE----------LKSEKQLYAIKVLKKEFILENDEVE 726
Query: 642 ELIVNE--ILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQ 699
+ LV +H +VN L + +TE ++ VM+++ GG L I+ Q
Sbjct: 727 STKSEKRVFLVANRERHPFLVN-LHSCFQTETRIYFVMDFVSGGDLMLHIQ--------Q 777
Query: 700 SPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKR 759
+ + + E C LK+ HD II+RD+K DN+LL G VK+ D+G C +
Sbjct: 778 EQFSRRRAQFYAAEVCLALKYFHDNGIIYRDLKLDNILLSPDGHVKVADYGLCKEDMWHD 837
Query: 760 SKRATMVGTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIAT 819
+ AT GTP +MAPE++ +++Y VD W+ G++ +ML + P+ E+ + I +
Sbjct: 838 NTTATFCGTPEFMAPEILLEQQYTRSVDWWAFGVLIYQMLLGQSPFRGEDEEEIFDAILS 897
Query: 820 NGTPKLKHPEYLSLEIKRFLSVCLCVDVKYRAST-----EELLHHSFFN 863
+ + +P ++ + L L D K R + E+++ H FF+
Sbjct: 898 D---EPLYPIHMPRDSVSILQQLLTRDPKKRLGSGPNDAEDVMTHPFFS 943
>Hs5730055 [D] KOG0575 Polo-like serine/threonine protein kinase
Length = 685
Score = 117 bits (292), Expect = 1e-25
Identities = 68/241 (28%), Positives = 128/241 (52%), Gaps = 15/241 (6%)
Query: 626 NKVAIKQMI----LSKQPRKELIVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYME 681
NKV ++I ++K ++E I EI + + H ++V F Y + ++++++++EY
Sbjct: 105 NKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKHVVQFYH-YFEDKENIYILLEYCS 163
Query: 682 GGSLTDIIENSPTGSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTR 741
S+ I++ + LTEP++ Y +R+ GLK+LH++ I+HRD+K N ++
Sbjct: 164 RRSMAHILK-------ARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINEA 216
Query: 742 GRVKITDFGFCAKLTDKRSKRATMVGTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLES 801
+K+ DFG A+L +R T+ GTP +++PEV+ ++ + + D+W+LG + ML
Sbjct: 217 MELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCESDIWALGCVMYTMLLG 276
Query: 802 EPPYLNEEPLKALYLIATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSF 861
PP+ LK Y + P L K ++ L + + R S ++++ H F
Sbjct: 277 RPPF-ETTNLKETYRCIREA--RYTMPSSLLAPAKHLIASMLSKNPEDRPSLDDIIRHDF 333
Query: 862 F 862
F
Sbjct: 334 F 334
>At2g31010 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 375
Score = 116 bits (291), Expect = 1e-25
Identities = 72/207 (34%), Positives = 113/207 (53%), Gaps = 8/207 (3%)
Query: 625 GNKVAIKQMILSKQPRKEL--IVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEG 682
G VAIK + + + NEI ++ +H N+V FL A K L ++ EYME
Sbjct: 77 GTDVAIKLFLEQDLTAENMEDFCNEISILSRVRHPNVVLFLGACTKPPR-LSMITEYMEL 135
Query: 683 GSLTDIIENSPTGSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRG 742
GSL +I S + L+ + ++R+ C+GL +H I+HRD+KS N L+D
Sbjct: 136 GSLYYLIHMS----GQKKKLSWHRRLRMLRDICRGLMCIHRMKIVHRDLKSANCLVDKHW 191
Query: 743 RVKITDFGFCAKLTDKRSKRATMVGTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESE 802
VKI DFG +TD+ K + GTP WMAPE+++ R + EK D++SLG++ E+
Sbjct: 192 TVKICDFGLSRIMTDENMKDTSSAGTPEWMAPELIRNRPFTEKCDIFSLGVIMWELSTLR 251
Query: 803 PPYLNEEPLKALYLIATNGTPKLKHPE 829
P+ P K ++ +A G+ +L+ P+
Sbjct: 252 KPWEGVPPEKVVFAVAHEGS-RLEIPD 277
>Hs4758702 [T] KOG4279 Serine/threonine protein kinase
Length = 1011
Score = 116 bits (290), Expect = 2e-25
Identities = 87/248 (35%), Positives = 126/248 (50%), Gaps = 28/248 (11%)
Query: 627 KVAIKQMILSKQPRKELIVNEILVMKDSKHNNIVNFLEA-----YLKTEDDLWVVMEYME 681
++AIK++ + + EI + + +H NIV +L + YLK + ME +
Sbjct: 396 RIAIKEIPERDSRFSQPLHEEIALHRRLRHKNIVRYLGSASQGGYLK------IFMEEVP 449
Query: 682 GGSLTDIIENSPTGSSGQSPL--TEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLD 739
GGSL+ ++ S PL E I++ R+ QGL +LHD HI+HRDIK DNVL++
Sbjct: 450 GGSLSSLLR------SVWGPLKDNESTISFYTRQILQGLGYLHDNHIVHRDIKGDNVLIN 503
Query: 740 T-RGRVKITDFGFCAKLTDKRSKRATMVGTPYWMAPEVVKQ--REYDEKVDVWSLGIMTI 796
T G +KI+DFG +L T GT +MAPE++ Q R Y + D+WSLG I
Sbjct: 504 TFSGLLKISDFGTSKRLAGITPCTETFTGTLQYMAPEIIDQGPRGYGKAADIWSLGCTVI 563
Query: 797 EMLESEPPYLN-EEPLKALYLIATNGTPKL--KHPEYLSLEIKRFLSVCLCVDVKYRAST 853
EM PP+ P A++ + G K+ P LS E + FL D + RAS
Sbjct: 564 EMATGRPPFHELGSPQAAMFQV---GMYKVHPPMPSSLSAEAQAFLLRTFEPDPRLRASA 620
Query: 854 EELLHHSF 861
+ LL F
Sbjct: 621 QTLLGDPF 628
>Hs15619015 [T] KOG0616 cAMP-dependent protein kinase catalytic subunit (PKA)
Length = 351
Score = 116 bits (290), Expect = 2e-25
Identities = 77/306 (25%), Positives = 147/306 (47%), Gaps = 25/306 (8%)
Query: 545 VGDSNQQKTTEVSKKKPSKPAMSNAEIMTNLKNVTFNMDPTPFFRMVEKAGQGASGSVYL 604
+G++ +K TE + A + + + N N + F + G G+ G V L
Sbjct: 1 MGNAPAKKDTEQEESVNEFLAKARGDFLYRWGNPAQNTASSDQFERLRTLGMGSFGRVML 60
Query: 605 AERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKELIVNEILVMKDSKHNNIVNFLE 664
+ K+ KQ ++ K + E I+NE +++ +V L+
Sbjct: 61 VRH----------QETGGHYAMKILNKQKVV-KMKQVEHILNEKRILQAIDFPFLVK-LQ 108
Query: 665 AYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAYIVRETCQGLKFLHDK 724
K L++VMEY+ GG + ++ +EP + + +++LH
Sbjct: 109 FSFKDNSYLYLVMEYVPGGEMFSRLQRV-------GRFSEPHACFYAAQVVLAVQYLHSL 161
Query: 725 HIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMVGTPYWMAPEVVKQREYDE 784
+IHRD+K +N+L+D +G +++TDFGF ++ + + T+ GTP ++APE++ + Y++
Sbjct: 162 DLIHRDLKPENLLIDQQGYLQVTDFGFAKRV---KGRTWTLCGTPEYLAPEIILSKGYNK 218
Query: 785 KVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTPKLKHPEYLSLEIKRFLSVCLC 844
VD W+LG++ EM PP+ ++P++ I + +++ P LS ++K L L
Sbjct: 219 AVDWWALGVLIYEMAVGFPPFYADQPIQIYEKIVSG---RVRFPSKLSSDLKHLLRSLLQ 275
Query: 845 VDVKYR 850
VD+ R
Sbjct: 276 VDLTKR 281
>Hs22062450 [R] KOG0586 Serine/threonine protein kinase
Length = 787
Score = 115 bits (289), Expect = 2e-25
Identities = 90/321 (28%), Positives = 155/321 (48%), Gaps = 34/321 (10%)
Query: 562 SKPAMSNAEIMTNLKNVTFNMDPTPF---FRMVEKAGQGASGSVYLAERLQLPPYKDELE 618
SKP S+ M +N + D P +R+++ G+G V LA +
Sbjct: 26 SKP--SSKSNMIRGRNSATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILT-------- 75
Query: 619 AEKNQLGNKVAIKQMILSKQPRKEL--IVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVV 676
G +VA+K + ++ L + E+ +MK H NIV E ++TE L++V
Sbjct: 76 ------GKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEV-IETEKTLYLV 128
Query: 677 MEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNV 736
MEY GG + D + + E + R+ +++ H K I+HRD+K++N+
Sbjct: 129 MEYASGGEVFDYLV-------AHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENL 181
Query: 737 LLDTRGRVKITDFGFCAKLTDKRSKRATMVGTPYWMAPEVVKQREYD-EKVDVWSLGIMT 795
LLD +KI DFGF + T +K T G+P + APE+ + ++YD +VDVWSLG++
Sbjct: 182 LLDADMNIKIADFGFSNEFT-FGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVIL 240
Query: 796 IEMLESEPPYLNEEPLKALYLIATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEE 855
++ P+ + + LK L G K + P Y+S + + L L ++ R + E+
Sbjct: 241 YTLVSGSLPF-DGQNLKELRERVLRG--KYRIPFYMSTDCENLLKKFLILNPSKRGTLEQ 297
Query: 856 LLHHSFFNMSCESQDLISLLE 876
++ + N+ E +L +E
Sbjct: 298 IMKDRWMNVGHEDDELKPYVE 318
>YKL166c [T] KOG0616 cAMP-dependent protein kinase catalytic subunit (PKA)
Length = 398
Score = 115 bits (288), Expect = 3e-25
Identities = 80/284 (28%), Positives = 133/284 (46%), Gaps = 36/284 (12%)
Query: 588 FRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQM---ILSKQPRKELI 644
F+++ G G+ G V+L N G A+K + + K + E
Sbjct: 88 FQILRTLGTGSFGRVHLIR--------------SNHNGRFYALKTLKKHTIVKLKQVEHT 133
Query: 645 VNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTE 704
+E ++ H I+ + ++ +++VM+Y+EGG L ++ S
Sbjct: 134 NDERRMLSIVSHPFIIRMWGTFQDSQQ-VFMVMDYIEGGELFSLLRKSQR-------FPN 185
Query: 705 PQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRAT 764
P + E C L++LH K II+RD+K +N+LLD G +KITDFGF + D T
Sbjct: 186 PVAKFYAAEVCLALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFAKYVPD---VTYT 242
Query: 765 MVGTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTPK 824
+ GTP ++APEVV + Y++ VD WS G++ EML P+ N +K I +
Sbjct: 243 LCGTPDYIAPEVVSTKPYNKSVDWWSFGVLIYEMLAGYTPFYNSNTMKTYENIL---NAE 299
Query: 825 LKHPEYLSLEIKRFLSVCLCVDVKYRA-----STEELLHHSFFN 863
LK P + + + L + D+ R +E++ +H +FN
Sbjct: 300 LKFPPFFHPDAQDLLKKLITRDLSERLGNLQNGSEDVKNHPWFN 343
>Hs7657526 [T] KOG0603 Ribosomal protein S6 kinase
Length = 745
Score = 115 bits (288), Expect = 3e-25
Identities = 79/279 (28%), Positives = 136/279 (48%), Gaps = 25/279 (8%)
Query: 588 FRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKELI-VN 646
F +++ GQG+ G V+L R + P +L A K + ++ + +K R L+ VN
Sbjct: 73 FELLKVLGQGSFGKVFLV-RKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDILVEVN 131
Query: 647 EILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQ 706
++K L +TE L+++++++ GG + T S + TE
Sbjct: 132 HPFIVK----------LHYAFQTEGKLYLILDFLRGGDVF-------TRLSKEVLFTEED 174
Query: 707 IAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMV 766
+ + + E L LH I++RD+K +N+LLD G +K+TDFG + D+ K +
Sbjct: 175 VKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFC 234
Query: 767 GTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTPKLK 826
GT +MAPEVV +R + + D WS G++ EML P+ ++ + + +I KL
Sbjct: 235 GTVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMIL---KAKLG 291
Query: 827 HPEYLSLEIKRFLSVCLCVDVKYRAST---EELLHHSFF 862
P++LS E + L + + R + EE+ H FF
Sbjct: 292 MPQFLSAEAQSLLRMLFKRNPANRLGSEGVEEIKRHLFF 330
Score = 88.2 bits (217), Expect = 5e-17
Identities = 91/332 (27%), Positives = 149/332 (44%), Gaps = 37/332 (11%)
Query: 553 TTEVSKKKPSKPAMSNAEIMTN-----LKNVTFNMDPTPF-----FRMVEKAGQGAS-GS 601
T + K P PA +NA + ++ TP +V+ G A G
Sbjct: 365 TAKTPKDSPGLPASANAHQLFKGFSFVATSIAEEYKITPITSANVLPIVQINGNAAQFGE 424
Query: 602 VY-LAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKELIVNEILVMKDSKHNNIV 660
VY L E + + Y + A+K + SK+ E I EIL M+ +H NI+
Sbjct: 425 VYELKEDIGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPSEEI--EIL-MRYGQHPNII 481
Query: 661 NFLEAYLKTEDD---LWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAYIVRETCQG 717
+ + DD +++V + M+GG L D I S ++ I Y++ +T
Sbjct: 482 TLKDVF----DDGRYVYLVTDLMKGGELLDRILKQKCFSEREAS----DILYVISKT--- 530
Query: 718 LKFLHDKHIIHRDIKSDNVLL----DTRGRVKITDFGFCAKLTDKRSKRATMVGTPYWMA 773
+ +LH + ++HRD+K N+L + ++I DFGF +L + T T ++A
Sbjct: 531 VDYLHCQGVVHRDLKPSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCYTANFVA 590
Query: 774 PEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLN--EEPLKALYLIATNGTPKLKHPEY- 830
PEV+ Q+ YD D+WSLG++ ML P+ N + + + L NG L +
Sbjct: 591 PEVLMQQGYDAACDIWSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGNGKFSLSGGNWD 650
Query: 831 -LSLEIKRFLSVCLCVDVKYRASTEELLHHSF 861
+S K LS L +D R + E++L HS+
Sbjct: 651 NISDGAKDLLSHMLHMDPHQRYTAEQILKHSW 682
>Hs4885563 [T] KOG0694 Serine/threonine protein kinase
Length = 737
Score = 115 bits (288), Expect = 3e-25
Identities = 68/218 (31%), Positives = 111/218 (50%), Gaps = 18/218 (8%)
Query: 588 FRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKELIVNE 647
F ++ G+G+ G V LAE KDE+ A K +K+ ++ + + + E
Sbjct: 408 FNFIKVLGKGSFGKVMLAELKG----KDEVYAVK-------VLKKDVILQDDDVDCTMTE 456
Query: 648 ILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQI 707
++ ++ + + L +T+D L+ VMEY+ GG L I+ S EP+
Sbjct: 457 KRILALARKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRS-------RKFDEPRS 509
Query: 708 AYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMVG 767
+ E L FLH +I+RD+K DN+LLD G K+ DFG C + T G
Sbjct: 510 RFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCG 569
Query: 768 TPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPY 805
TP ++APE++++ EY VD W+LG++ EM+ +PP+
Sbjct: 570 TPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPF 607
>Hs4885061 [T] KOG0690 Serine/threonine protein kinase
Length = 480
Score = 115 bits (287), Expect = 4e-25
Identities = 82/281 (29%), Positives = 135/281 (47%), Gaps = 28/281 (9%)
Query: 588 FRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKELIVNE 647
F ++ G+G G V L + +A K+ K++I++K + E
Sbjct: 150 FEYLKLLGKGTFGKVILVKE----------KATGRYYAMKILKKEVIVAKDEVAHTLT-E 198
Query: 648 ILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQI 707
V+++S+H + L+ +T D L VMEY GG L + S + +E +
Sbjct: 199 NRVLQNSRHP-FLTALKYSFQTHDRLCFVMEYANGGELFFHL-------SRERVFSEDRA 250
Query: 708 AYIVRETCQGLKFLH-DKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMV 766
+ E L +LH +K++++RD+K +N++LD G +KITDFG C + + T
Sbjct: 251 RFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFC 310
Query: 767 GTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTPKLK 826
GTP ++APEV++ +Y VD W LG++ EM+ P+ N++ K LI +++
Sbjct: 311 GTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILME---EIR 367
Query: 827 HPEYLSLEIKRFLSVCLCVDVKYR-----ASTEELLHHSFF 862
P L E K LS L D K R +E++ H FF
Sbjct: 368 FPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFF 408
>Hs4506067 [T] KOG0696 Serine/threonine protein kinase
Length = 672
Score = 115 bits (287), Expect = 4e-25
Identities = 94/338 (27%), Positives = 151/338 (43%), Gaps = 42/338 (12%)
Query: 538 PAREAPRVGDSNQQKTTEVSKKKPS-----KPAMSNAEIMTNLKNVTFNMDPTPFFRMVE 592
P E G+ ++ E +K P+ P+ + NL V F +
Sbjct: 289 PIPEGDEEGNMELRQKFEKAKLGPAGNKVISPSEDRKQPSNNLDRVKLTD-----FNFLM 343
Query: 593 KAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKELIVNEILVMK 652
G+G+ G V LA+R +EL A K +K+ ++ + E + E V+
Sbjct: 344 VLGKGSFGKVMLADRKGT----EELYAIK-------ILKKDVVIQDDDVECTMVEKRVLA 392
Query: 653 DSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAYIVR 712
+ L + +T D L+ VMEY+ GG L I+ EPQ +
Sbjct: 393 LLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQV-------GKFKEPQAVFYAA 445
Query: 713 ETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMVGTPYWM 772
E GL FLH + II+RD+K DNV+LD+ G +KI DFG C + T GTP ++
Sbjct: 446 EISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYI 505
Query: 773 APEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTPKLKHPEYLS 832
APE++ + Y + VD W+ G++ EML +PP+ E+ + I + + +P+ LS
Sbjct: 506 APEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEH---NVSYPKSLS 562
Query: 833 LEIKRFLSVCLCVDVKYRA--------STEELLHHSFF 862
K +S+C + K+ A ++ H+FF
Sbjct: 563 ---KEAVSICKGLMTKHPAKRLGCGPEGERDVREHAFF 597
>Hs4505373 [V] KOG1826 Ras GTPase activating protein RasGAP/neurofibromin
Length = 445
Score = 115 bits (287), Expect = 4e-25
Identities = 70/228 (30%), Positives = 118/228 (51%), Gaps = 11/228 (4%)
Query: 638 QPRKELIVNEILVMKDSKHNNIVNFLEAYL-KTEDDLWVVMEYMEGGSLTDIIENSPTGS 696
+ K+++V+E+ ++++ KH NIV + + + +T L++VMEY EGG L +I G+
Sbjct: 46 EAEKQMLVSEVNLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITK---GT 102
Query: 697 SGQSPLTEPQIAYIVRETCQGLKFLHDKH-----IIHRDIKSDNVLLDTRGRVKITDFGF 751
+ L E + ++ + LK H + ++HRD+K NV LD + VK+ DFG
Sbjct: 103 KERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGL 162
Query: 752 CAKLTDKRSKRATMVGTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPL 811
L S T VGTPY+M+PE + + Y+EK D+WSLG + E+ PP+
Sbjct: 163 ARILNHDTSFAKTFVGTPYYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQK 222
Query: 812 KALYLIATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHH 859
+ I ++ P S E+ ++ L + +R S EE+L +
Sbjct: 223 ELAGKIREGKFRRI--PYRYSDELNEIITRMLNLKDYHRPSVEEILEN 268
>Hs22057171 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 456
Score = 115 bits (287), Expect = 4e-25
Identities = 76/250 (30%), Positives = 130/250 (51%), Gaps = 13/250 (5%)
Query: 618 EAEKNQLGNKVAIKQMILSKQPRKELIVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVM 677
+ E+ G K+A K + KE + NEI VM H N++ +A+ ++++D+ +VM
Sbjct: 190 KCEETATGLKLAAKIIKTRGMKDKEEVKNEISVMNQLDHANLIQLYDAF-ESKNDIVLVM 248
Query: 678 EYMEGGSLTD-IIENSPTGSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNV 736
EY++GG L D II+ S LTE +++ C+G++ +H +I+H D+K +N+
Sbjct: 249 EYVDGGELFDRIIDESYN-------LTELDTILFMKQICEGIRHMHQMYILHLDLKPENI 301
Query: 737 LLDTRG--RVKITDFGFCAKLTDKRSKRATMVGTPYWMAPEVVKQREYDEKVDVWSLGIM 794
L R ++KI DFG A+ R K GTP ++APEVV D+WS+G++
Sbjct: 302 LCVNRDAKQIKIIDFGL-ARRYKPREKLKVNFGTPEFLAPEVVNYDFVSFPTDMWSVGVI 360
Query: 795 TIEMLESEPPYLNEEPLKAL-YLIATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYRAST 853
+L P+L + + L ++A + + + +S E K F+S L + +R S
Sbjct: 361 AYMLLSGLSPFLGDNDAETLNNILACRWDLEDEEFQDISEEAKEFISKLLIKEKSWRISA 420
Query: 854 EELLHHSFFN 863
E L H + +
Sbjct: 421 SEALKHPWLS 430
>Hs20479818 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 514
Score = 115 bits (287), Expect = 4e-25
Identities = 77/285 (27%), Positives = 145/285 (50%), Gaps = 34/285 (11%)
Query: 617 LEAEKNQLGNKVAIKQMILSKQPRK--ELIVNEILVMKDSKHNNIVNFLEAYLKTEDDLW 674
+EA + K AIK++ K +L+ E+ ++K KH +I++ LE +T ++
Sbjct: 131 IEATDKETETKWAIKKVNKEKAGSSAVKLLEREVNILKSVKHEHIIH-LEQVFETPKKMY 189
Query: 675 VVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSD 734
+VME E G L +I++ + +E + +I++ + +LH+ I+HRD+K +
Sbjct: 190 LVMELCEDGELKEILDR-------KGHFSENETRWIIQSLASAIAYLHNNDIVHRDLKLE 242
Query: 735 NVLL---------DTRGRVKITDFGFCAKLTDKRSKRATMV----GTPYWMAPEVVKQRE 781
N+++ + +K+TDFG K K+S+ M+ GTP +MAPEV+ +
Sbjct: 243 NIMVKSSLIDDNNEINLNIKVTDFGLAVK---KQSRSEAMLQATCGTPIYMAPEVISAHD 299
Query: 782 YDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTPKLKHPEYLSLE--IKRFL 839
Y ++ D+WS+G++ +L EPP+L K L+ + G ++ + S+ K L
Sbjct: 300 YSQQCDIWSIGVVMYMLLRGEPPFLASSEEK-LFELIRKGELHFENAVWNSISDCAKSVL 358
Query: 840 SVCLCVDVKYRASTEELLHHSFFN----MSCESQDLISLL-EWKN 879
+ VD +R + +ELL + + S +++ ++ EWKN
Sbjct: 359 KQLMKVDPAHRITAKELLDNQWLTGNKLSSVRPTNVLEMMKEWKN 403
>CE29092 [T] KOG0694 Serine/threonine protein kinase
Length = 707
Score = 115 bits (287), Expect = 4e-25
Identities = 71/260 (27%), Positives = 130/260 (49%), Gaps = 21/260 (8%)
Query: 546 GDSNQQKTTEVSKKKPSKPAMSNAEIMTNLKNVTFNMDPTPFFRMVEKAGQGASGSVYLA 605
G SN + + + + +++ + + T ++ F +++ G+G+ G V LA
Sbjct: 339 GSSNSENSGYLQQISEDDSGTTSSRSASKVPGGTLSIHDFTFMKVL---GKGSFGKVMLA 395
Query: 606 ERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKELIVNEILVMKDSKHNNIVNFLEA 665
ER DE+ A K +K+ ++ + E + E ++ + + + L +
Sbjct: 396 ERKGT----DEVYAIK-------ILKKDVIVQDDDVECTMCEKRILSLAAKHPFLTALHS 444
Query: 666 YLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAYIVRETCQGLKFLHDKH 725
+T D L+ VMEY+ GG L I+ + E + + E L+FLH
Sbjct: 445 SFQTSDRLFFVMEYVNGGDLMFQIQRA-------RKFDESRARFYAAEVTCALQFLHRND 497
Query: 726 IIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMVGTPYWMAPEVVKQREYDEK 785
+I+RD+K DN+LLD G ++ DFG C + +K + +T GTP ++APE++++ EY
Sbjct: 498 VIYRDLKLDNILLDAEGHCRLADFGMCKEGINKDNLTSTFCGTPDYIAPEILQEMEYGVS 557
Query: 786 VDVWSLGIMTIEMLESEPPY 805
VD W+LG++ EM+ +PP+
Sbjct: 558 VDWWALGVLMYEMMAGQPPF 577
>Hs14993776 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 596
Score = 114 bits (286), Expect = 5e-25
Identities = 88/290 (30%), Positives = 143/290 (48%), Gaps = 14/290 (4%)
Query: 584 PTPF-FRMVEKAGQGASG--SVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPR 640
P PF RMVE S S+ E L + + G K+A K +
Sbjct: 264 PAPFPHRMVELRTGNVSSEFSMNSKEALGGGKFGAVCTCMEKATGLKLAAKVIKKQTPKD 323
Query: 641 KELIVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQS 700
KE+++ EI VM H N++ L A ++T ++ + MEY+EGG L + I +
Sbjct: 324 KEMVLLEIEVMNQLNHRNLIQ-LYAAIETPHEIVLFMEYIEGGELFERIVDE------DY 376
Query: 701 PLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVL-LDTRGR-VKITDFGFCAKLTDK 758
LTE VR+ C G+ F+H ++H D+K +N+L ++T G VKI DFG A+ +
Sbjct: 377 HLTEVDTMVFVRQICDGILFMHKMRVLHLDLKPENILCVNTTGHLVKIIDFGL-ARRYNP 435
Query: 759 RSKRATMVGTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKAL-YLI 817
K GTP +++PEVV + +K D+WS+G++T +L P+L ++ + L ++
Sbjct: 436 NEKLKVNFGTPEFLSPEVVNYDQISDKTDMWSMGVITYMLLSGLSPFLGDDDTETLNNVL 495
Query: 818 ATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSFFNMSCE 867
+ N + E +S E K F+S + D + R + + L H + N E
Sbjct: 496 SGNWYFDEETFEAVSDEAKDFVSNLIVKDQRARMNAAQCLAHPWLNNLAE 545
>CE15475 [T] KOG0616 cAMP-dependent protein kinase catalytic subunit (PKA)
Length = 375
Score = 114 bits (286), Expect = 5e-25
Identities = 84/341 (24%), Positives = 157/341 (45%), Gaps = 34/341 (9%)
Query: 543 PRVGDSNQQKTTEVSKKKPSKPAMSNAEIMTNLKNVTFNMDPTPFFRMVEKAGQGASGSV 602
P+ D K + S + + +N N F ++ G G+ G V
Sbjct: 7 PKSSDEGSSKDNKNSASLKEFLDKAREDFKQRWENPAQNTACLDDFDRIKTLGTGSFGRV 66
Query: 603 YLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKELIVNEILVMKDSKHNNIVNF 662
L + Q N K+ KQ ++ K + E +NE +++ +VN
Sbjct: 67 MLVKHKQ----------SGNYYAMKILDKQKVV-KLKQVEHTLNEKRILQAIDFPFLVNM 115
Query: 663 LEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAYIVRETCQGLKFLH 722
++ K +L++V+E++ GG + + +EP + + ++LH
Sbjct: 116 TFSF-KDNSNLYMVLEFISGGEMFSHLRRI-------GRFSEPHSRFYAAQIVLAFEYLH 167
Query: 723 DKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMVGTPYWMAPEVVKQREY 782
+I+RD+K +N+L+D+ G +KITDFGF ++ + + T+ GTP ++APE++ + Y
Sbjct: 168 SLDLIYRDLKPENLLIDSTGYLKITDFGFAKRV---KGRTWTLCGTPEYLAPEIILSKGY 224
Query: 783 DEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTPKLKHPEYLSLEIKRFLSVC 842
++ VD W+LG++ EM PP+ ++P++ I + K+K P + S E+K L
Sbjct: 225 NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG---KVKFPSHFSNELKDLLKNL 281
Query: 843 LCVDVKYR-----ASTEELLHHSFFNMSCESQDLISLLEWK 878
L VD+ R ++ +H +F S D I++ + K
Sbjct: 282 LQVDLTKRYGNLKNGVADIKNHKWFG----STDWIAIYQKK 318
>CE15473 [T] KOG0616 cAMP-dependent protein kinase catalytic subunit (PKA)
Length = 359
Score = 114 bits (286), Expect = 5e-25
Identities = 84/341 (24%), Positives = 157/341 (45%), Gaps = 34/341 (9%)
Query: 543 PRVGDSNQQKTTEVSKKKPSKPAMSNAEIMTNLKNVTFNMDPTPFFRMVEKAGQGASGSV 602
P+ D K + S + + +N N F ++ G G+ G V
Sbjct: 7 PKSSDEGSSKDNKNSASLKEFLDKAREDFKQRWENPAQNTACLDDFDRIKTLGTGSFGRV 66
Query: 603 YLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKELIVNEILVMKDSKHNNIVNF 662
L + Q N K+ KQ ++ K + E +NE +++ +VN
Sbjct: 67 MLVKHKQ----------SGNYYAMKILDKQKVV-KLKQVEHTLNEKRILQAIDFPFLVNM 115
Query: 663 LEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAYIVRETCQGLKFLH 722
++ K +L++V+E++ GG + + +EP + + ++LH
Sbjct: 116 TFSF-KDNSNLYMVLEFISGGEMFSHLRRI-------GRFSEPHSRFYAAQIVLAFEYLH 167
Query: 723 DKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMVGTPYWMAPEVVKQREY 782
+I+RD+K +N+L+D+ G +KITDFGF ++ + + T+ GTP ++APE++ + Y
Sbjct: 168 SLDLIYRDLKPENLLIDSTGYLKITDFGFAKRV---KGRTWTLCGTPEYLAPEIILSKGY 224
Query: 783 DEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTPKLKHPEYLSLEIKRFLSVC 842
++ VD W+LG++ EM PP+ ++P++ I + K+K P + S E+K L
Sbjct: 225 NKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG---KVKFPSHFSNELKDLLKNL 281
Query: 843 LCVDVKYR-----ASTEELLHHSFFNMSCESQDLISLLEWK 878
L VD+ R ++ +H +F S D I++ + K
Sbjct: 282 LQVDLTKRYGNLKNGVADIKNHKWFG----STDWIAIYQKK 318
>Hs9845489 [R] KOG0586 Serine/threonine protein kinase
Length = 691
Score = 114 bits (285), Expect = 7e-25
Identities = 82/292 (28%), Positives = 144/292 (49%), Gaps = 29/292 (9%)
Query: 588 FRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKEL--IV 645
+R+++ G+G V LA + G +VA+K + ++ L +
Sbjct: 20 YRLLKTIGKGNFAKVKLARHILT--------------GKEVAVKIIDKTQLNSSSLQKLF 65
Query: 646 NEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEP 705
E+ +MK H NIV E ++TE L++VMEY GG + D + + E
Sbjct: 66 REVRIMKVLNHPNIVKLFEV-IETEKTLYLVMEYASGGEVFDYLV-------AHGRMKEK 117
Query: 706 QIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATM 765
+ R+ +++ H K I+HRD+K++N+LLD +KI DFGF + T +K T
Sbjct: 118 EARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFT-FGNKLDTF 176
Query: 766 VGTPYWMAPEVVKQREYD-EKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTPK 824
G+P + APE+ + ++YD +VDVWSLG++ ++ P+ + + LK L G K
Sbjct: 177 CGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPF-DGQNLKELRERVLRG--K 233
Query: 825 LKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSFFNMSCESQDLISLLE 876
+ P Y+S + + L L ++ R + E+++ + N+ E +L +E
Sbjct: 234 YRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVE 285
>Hs9845487 [R] KOG0586 Serine/threonine protein kinase
Length = 745
Score = 114 bits (285), Expect = 7e-25
Identities = 82/292 (28%), Positives = 144/292 (49%), Gaps = 29/292 (9%)
Query: 588 FRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKEL--IV 645
+R+++ G+G V LA + G +VA+K + ++ L +
Sbjct: 20 YRLLKTIGKGNFAKVKLARHILT--------------GKEVAVKIIDKTQLNSSSLQKLF 65
Query: 646 NEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEP 705
E+ +MK H NIV E ++TE L++VMEY GG + D + + E
Sbjct: 66 REVRIMKVLNHPNIVKLFEV-IETEKTLYLVMEYASGGEVFDYLV-------AHGRMKEK 117
Query: 706 QIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATM 765
+ R+ +++ H K I+HRD+K++N+LLD +KI DFGF + T +K T
Sbjct: 118 EARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFT-FGNKLDTF 176
Query: 766 VGTPYWMAPEVVKQREYD-EKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTPK 824
G+P + APE+ + ++YD +VDVWSLG++ ++ P+ + + LK L G K
Sbjct: 177 CGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPF-DGQNLKELRERVLRG--K 233
Query: 825 LKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSFFNMSCESQDLISLLE 876
+ P Y+S + + L L ++ R + E+++ + N+ E +L +E
Sbjct: 234 YRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVE 285
>CE27768 [R] KOG0586 Serine/threonine protein kinase
Length = 1096
Score = 114 bits (285), Expect = 7e-25
Identities = 77/257 (29%), Positives = 134/257 (51%), Gaps = 19/257 (7%)
Query: 625 GNKVAIKQMILSKQPRK----ELIVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYM 680
G++VAIK I+ K + + E+ +MK H NIV + ++TE L++V+EY
Sbjct: 145 GHEVAIK--IIDKTALNPSSLQKLFREVKIMKQLDHPNIVKLYQV-METEQTLYLVLEYA 201
Query: 681 EGGSLTDIIENSPTGSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDT 740
GG + D + + E + R+ +++LH K+IIHRD+K++N+LLD
Sbjct: 202 SGGEVFDYLV-------AHGRMKEKEARAKFRQIVSAVQYLHSKNIIHRDLKAENLLLDQ 254
Query: 741 RGRVKITDFGFCAKLTDKRSKRATMVGTPYWMAPEVVKQREYD-EKVDVWSLGIMTIEML 799
+KI DFGF + +K T G+P + APE+ ++YD +VDVWSLG++ ++
Sbjct: 255 DMNIKIADFGF-SNTFSLGNKLDTFCGSPPYAAPELFSGKKYDGPEVDVWSLGVILYTLV 313
Query: 800 ESEPPYLNEEPLKALYLIATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHH 859
P+ + + LK L G K + P Y+S + + L L ++ + R+S + ++
Sbjct: 314 SGSLPF-DGQNLKELRERVLRG--KYRIPFYMSTDCENLLKKFLVINPQRRSSLDNIMKD 370
Query: 860 SFFNMSCESQDLISLLE 876
+ N+ E +L +E
Sbjct: 371 RWMNVGYEDDELKPFIE 387
>CE23838 [R] KOG0586 Serine/threonine protein kinase
Length = 1192
Score = 114 bits (285), Expect = 7e-25
Identities = 77/257 (29%), Positives = 134/257 (51%), Gaps = 19/257 (7%)
Query: 625 GNKVAIKQMILSKQPRK----ELIVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYM 680
G++VAIK I+ K + + E+ +MK H NIV + ++TE L++V+EY
Sbjct: 193 GHEVAIK--IIDKTALNPSSLQKLFREVKIMKQLDHPNIVKLYQV-METEQTLYLVLEYA 249
Query: 681 EGGSLTDIIENSPTGSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDT 740
GG + D + + E + R+ +++LH K+IIHRD+K++N+LLD
Sbjct: 250 SGGEVFDYLV-------AHGRMKEKEARAKFRQIVSAVQYLHSKNIIHRDLKAENLLLDQ 302
Query: 741 RGRVKITDFGFCAKLTDKRSKRATMVGTPYWMAPEVVKQREYD-EKVDVWSLGIMTIEML 799
+KI DFGF + +K T G+P + APE+ ++YD +VDVWSLG++ ++
Sbjct: 303 DMNIKIADFGF-SNTFSLGNKLDTFCGSPPYAAPELFSGKKYDGPEVDVWSLGVILYTLV 361
Query: 800 ESEPPYLNEEPLKALYLIATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHH 859
P+ + + LK L G K + P Y+S + + L L ++ + R+S + ++
Sbjct: 362 SGSLPF-DGQNLKELRERVLRG--KYRIPFYMSTDCENLLKKFLVINPQRRSSLDNIMKD 418
Query: 860 SFFNMSCESQDLISLLE 876
+ N+ E +L +E
Sbjct: 419 RWMNVGYEDDELKPFIE 435
>SPCC320.12c [D] KOG0580 Serine/threonine protein kinase
Length = 384
Score = 114 bits (284), Expect = 9e-25
Identities = 87/333 (26%), Positives = 157/333 (47%), Gaps = 43/333 (12%)
Query: 544 RVGDSNQQKTTEVSKKKPSK-PAMSNAEIMTNLKNVTFNMDPTP-------------FFR 589
R+ SNQ++ VS + SN++ ++L+ + + P F
Sbjct: 60 RLAVSNQRQVNNVSLANGKENKRTSNSKFNSSLRKIEEPIAGVPSSAGPQWREFHIGMFE 119
Query: 590 MVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKEL---IVN 646
+ + G+G G VYLA+ + + G VA+K + S+ + ++ +
Sbjct: 120 IGKPLGKGKFGRVYLAK--------------EKKTGFIVALKTLHKSELVQSKIEKQVRR 165
Query: 647 EILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQ 706
EI + + +H NI+ L + E +++++E+ G L + + S E
Sbjct: 166 EIEIQSNLRHKNILR-LYGHFHDEKRIYLILEFAGRGELYQHLRRAKRFS-------EEV 217
Query: 707 IAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMV 766
+ + + L +LH KH+IHRDIK +N+LL G +K++DFG+ R R T+
Sbjct: 218 ASKYIFQMANALSYLHKKHVIHRDIKPENILLGIDGEIKLSDFGWSVHAPSNR--RTTLC 275
Query: 767 GTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTPKLK 826
GT ++ PE+V+ +E+ EKVD+WSLG++T E L PP+ + A Y LK
Sbjct: 276 GTLDYLPPEMVEGKEHTEKVDLWSLGVLTYEFLVGAPPFEDMSGHSATY--KRIAKVDLK 333
Query: 827 HPEYLSLEIKRFLSVCLCVDVKYRASTEELLHH 859
P ++ + + +S L + + R S E+++ H
Sbjct: 334 IPSFVPPDARDLISRLLQHNPEKRMSLEQVMRH 366
>Hs8923922 [R] KOG0586 Serine/threonine protein kinase
Length = 795
Score = 114 bits (284), Expect = 9e-25
Identities = 76/250 (30%), Positives = 132/250 (52%), Gaps = 15/250 (6%)
Query: 625 GNKVAIKQMILSKQPRKEL--IVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEG 682
G +VA+K + ++ L + E+ +MK H NIV E ++TE L++VMEY G
Sbjct: 83 GREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEV-IETEKTLYLVMEYASG 141
Query: 683 GSLTDIIENSPTGSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRG 742
G + D + + E + R+ +++ H K+I+HRD+K++N+LLD
Sbjct: 142 GEVFDYLV-------AHGRMKEKEARAKFRQIVSAVQYCHQKYIVHRDLKAENLLLDGDM 194
Query: 743 RVKITDFGFCAKLTDKRSKRATMVGTPYWMAPEVVKQREYD-EKVDVWSLGIMTIEMLES 801
+KI DFGF + T +K T G+P + APE+ + ++YD +VDVWSLG++ ++
Sbjct: 195 NIKIADFGFSNEFT-VGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSG 253
Query: 802 EPPYLNEEPLKALYLIATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSF 861
P+ + + LK L G K + P Y+S + + L L ++ R S E+++ +
Sbjct: 254 SLPF-DGQNLKELRERVLRG--KYRIPFYMSTDCENLLKKLLVLNPIKRGSLEQIMKDRW 310
Query: 862 FNMSCESQDL 871
N+ E ++L
Sbjct: 311 MNVGHEEEEL 320
>Hs20535816 [T] KOG0695 Serine/threonine protein kinase
Length = 592
Score = 114 bits (284), Expect = 9e-25
Identities = 92/351 (26%), Positives = 156/351 (44%), Gaps = 43/351 (12%)
Query: 536 LQPAREAPRVGDSNQ------QKTTEVSKKKPSKPAMSNAEIMTNLKNVTFNMDPTPF-- 587
+ P++E P V D N+ ++T ++ S+ S + +LK V MD
Sbjct: 187 VMPSQEPP-VDDKNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDGIKISQ 245
Query: 588 ------FRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRK 641
F ++ G+G+ V L + D++ A K +K+ ++
Sbjct: 246 GLGLQDFDLIRVIGRGSYAKVLLVRLKK----NDQIYAMK-------VVKKELVHDDEDI 294
Query: 642 ELIVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSP 701
+ + E V + + N + L + +T L++V+EY+ GG L ++ Q
Sbjct: 295 DWVQTEKHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQR-------QRK 347
Query: 702 LTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSK 761
L E + E C L FLH++ II+RD+K DNVLLD G +K+TD+G C +
Sbjct: 348 LPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDT 407
Query: 762 RATMVGTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPY----LNEEPLKALYLI 817
+T GTP ++APE+++ EY VD W+LG++ EM+ P+ N + YL
Sbjct: 408 TSTFCGTPNYIAPEILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLF 467
Query: 818 ATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYR------ASTEELLHHSFF 862
++ P +LS++ L L D K R ++ H+FF
Sbjct: 468 QVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFF 518
>Hs19923570 [T] KOG0603 Ribosomal protein S6 kinase
Length = 733
Score = 114 bits (284), Expect = 9e-25
Identities = 86/319 (26%), Positives = 152/319 (46%), Gaps = 27/319 (8%)
Query: 549 NQQKTTEVSKKKPSKPAMSNAEIMTNLKNVTFNMDPTPFFRMVEKAGQGASGSVYLAERL 608
++ K++ +S+ + + + +I ++K DP+ F +++ GQG+ G V+L ++
Sbjct: 22 SRSKSSSLSRLE-EEGVVKEIDISHHVKEGFEKADPSQF-ELLKVLGQGSYGKVFLVRKV 79
Query: 609 QLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKELIVNEILVMKDSKHNNIVNFLEAYLK 668
+ +L A K + ++ + SK R ++ + H IV A+ +
Sbjct: 80 KGSD-AGQLYAMKVLKKATLKVRDRVRSKMERD--------ILAEVNHPFIVKLHYAF-Q 129
Query: 669 TEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIH 728
TE L+++++++ GG L T S + TE + + + E L LH II+
Sbjct: 130 TEGKLYLILDFLRGGDLF-------TRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIY 182
Query: 729 RDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMVGTPYWMAPEVVKQREYDEKVDV 788
RD+K +N+LLD G +KITDFG + D + + GT +MAPEVV +R + + D
Sbjct: 183 RDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNRRGHTQSADW 242
Query: 789 WSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTPKLKHPEYLSLEIKRFLSVCLCVDVK 848
WS G++ EML P+ ++ + + LI KL P++LS E + L +
Sbjct: 243 WSFGVLMFEMLTGSLPFQGKDRKETMALIL---KAKLGMPQFLSGEAQSLLRALFKRNPC 299
Query: 849 YRA-----STEELLHHSFF 862
R EE+ H FF
Sbjct: 300 NRLGAGIDGVEEIKRHPFF 318
Score = 85.1 bits (209), Expect = 4e-16
Identities = 72/242 (29%), Positives = 118/242 (48%), Gaps = 25/242 (10%)
Query: 629 AIKQMILSKQPRKELIVNEILVMKDSKHNNIVNFLEAYLKTEDD---LWVVMEYMEGGSL 685
A+K + SK+ E I EIL ++ +H NI+ + Y DD +++VME M GG L
Sbjct: 442 AVKIIDKSKRDPSEEI--EIL-LRYGQHPNIITLKDVY----DDGKFVYLVMELMRGGEL 494
Query: 686 TDIIENSPTGSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLL-DTRGR- 743
D I Q +E + + ++ + + +LH + ++HRD+K N+L D G
Sbjct: 495 LDRILR-------QRYFSEREASDVLCTITKTMDYLHSQGVVHRDLKPSNILYRDESGSP 547
Query: 744 --VKITDFGFCAKLTDKRSKRATMVGTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLES 801
+++ DFGF +L T T ++APEV+K++ YD D+WSLGI+ ML
Sbjct: 548 ESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGILLYTMLAG 607
Query: 802 EPPYLNEEPLKALYLIATNGTPKLK----HPEYLSLEIKRFLSVCLCVDVKYRASTEELL 857
P+ N ++A G+ K + + +S K +S L VD R + ++L
Sbjct: 608 FTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPHQRLTAMQVL 667
Query: 858 HH 859
H
Sbjct: 668 KH 669
>Hs10864650 [T] KOG0695 Serine/threonine protein kinase
Length = 592
Score = 114 bits (284), Expect = 9e-25
Identities = 92/351 (26%), Positives = 156/351 (44%), Gaps = 43/351 (12%)
Query: 536 LQPAREAPRVGDSNQ------QKTTEVSKKKPSKPAMSNAEIMTNLKNVTFNMDPTPF-- 587
+ P++E P V D N+ ++T ++ S+ S + +LK V MD
Sbjct: 187 VMPSQEPP-VDDKNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDGIKISQ 245
Query: 588 ------FRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRK 641
F ++ G+G+ V L + D++ A K +K+ ++
Sbjct: 246 GLGLQDFDLIRVIGRGSYAKVLLVRLKK----NDQIYAMK-------VVKKELVHDDEDI 294
Query: 642 ELIVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSP 701
+ + E V + + N + L + +T L++V+EY+ GG L ++ Q
Sbjct: 295 DWVQTEKHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQR-------QRK 347
Query: 702 LTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSK 761
L E + E C L FLH++ II+RD+K DNVLLD G +K+TD+G C +
Sbjct: 348 LPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDT 407
Query: 762 RATMVGTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPY----LNEEPLKALYLI 817
+T GTP ++APE+++ EY VD W+LG++ EM+ P+ N + YL
Sbjct: 408 TSTFCGTPNYIAPEILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLF 467
Query: 818 ATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYR------ASTEELLHHSFF 862
++ P +LS++ L L D K R ++ H+FF
Sbjct: 468 QVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFF 518
>YPL203w [T] KOG0616 cAMP-dependent protein kinase catalytic subunit (PKA)
Length = 380
Score = 113 bits (283), Expect = 1e-24
Identities = 77/281 (27%), Positives = 138/281 (48%), Gaps = 30/281 (10%)
Query: 588 FRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKELIVNE 647
F+++ G G+ G V+L + Y KV KQ ++ K + E +E
Sbjct: 70 FQIMRTLGTGSFGRVHLVRSVHNGRY----------YAIKVLKKQQVV-KMKQVEHTNDE 118
Query: 648 ILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQI 707
++K +H ++ + + +++VM+Y+EGG L ++ S P
Sbjct: 119 RRMLKLVEHPFLIRMWGTFQDARN-IFMVMDYIEGGELFSLLRKSQR-------FPNPVA 170
Query: 708 AYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMVG 767
+ E L++LH +II+RD+K +N+LLD G +KITDFGF ++ ++ T+ G
Sbjct: 171 KFYAAEVILALEYLHAHNIIYRDLKPENILLDRNGHIKITDFGFAKEV---QTVTWTLCG 227
Query: 768 TPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTPKLKH 827
TP ++APEV+ + Y++ VD WSLG++ EML P+ + P+K I K+ +
Sbjct: 228 TPDYIAPEVITTKPYNKSVDWWSLGVLIYEMLAGYTPFYDTTPMKTYEKILQG---KVVY 284
Query: 828 PEYLSLEIKRFLSVCLCVDVKYR-----ASTEELLHHSFFN 863
P Y ++ LS + D+ R + + ++ H +F+
Sbjct: 285 PPYFHPDVVDLLSKLITADLTRRIGNLQSGSRDIKAHPWFS 325
>Hs10835065 [T] KOG0616 cAMP-dependent protein kinase catalytic subunit (PKA)
Length = 277
Score = 113 bits (283), Expect = 1e-24
Identities = 69/209 (33%), Positives = 112/209 (53%), Gaps = 16/209 (7%)
Query: 628 VAIKQMILSKQPRKELIVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTD 687
++I +I KQ ++ + NE V+K+ H ++ + + E L+++MEY+ GG L
Sbjct: 80 MSIPDVIRRKQ--EQHVHNEKSVLKEVSHPFLIRLFWTWHE-ERFLYMLMEYVPGGELFS 136
Query: 688 IIENSPTGSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKIT 747
+ N SS + Y C +++LH K I++RD+K +N+LLD G +K+T
Sbjct: 137 YLRNRGHFSSTTG------LFYSAEIIC-AIEYLHSKEIVYRDLKPENILLDRDGHIKLT 189
Query: 748 DFGFCAKLTDKRSKRATMVGTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLN 807
DFGF KL D + T+ GTP ++APEV++ + + VD W+LGI+ EML PP+ +
Sbjct: 190 DFGFAKKLVD---RTWTLCGTPEYLAPEVIQSKGHGRAVDWWALGILIFEMLSGFPPFFD 246
Query: 808 EEPLKALYLIATNGTPKLKHPEYLSLEIK 836
+ P I KL P +L +K
Sbjct: 247 DNPFGIYQKILAG---KLYFPRHLDFHVK 272
>CE23702 [T] KOG4721 Serine/threonine protein kinase contains leucine zipper
domain
Length = 855
Score = 113 bits (283), Expect = 1e-24
Identities = 80/270 (29%), Positives = 126/270 (46%), Gaps = 34/270 (12%)
Query: 591 VEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNK-VAIKQMILSKQPRKELIVNEIL 649
+E G G+ G+V+ + QL N+ VA+K++ +L EI
Sbjct: 65 LEWLGSGSQGAVF-----------------RGQLENRTVAVKKV-------NQLKETEIK 100
Query: 650 VMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAY 709
++ +H NI+ FL K+ +VMEY G L ++++ T +T A
Sbjct: 101 HLRHLRHQNIIEFLGVCSKSPC-YCIVMEYCSKGQLCTVLKSRNT-------ITRELFAQ 152
Query: 710 IVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMVGTP 769
V+E G+ +LH +IHRD+KS N+L+ +KI DFG S + GT
Sbjct: 153 WVKEIADGMHYLHQNKVIHRDLKSPNILISAEDSIKICDFGTSHMQKKMDSTMMSFCGTV 212
Query: 770 YWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTPKLKHPE 829
WMAPE++K++ +EKVDV+S G++ EML E PY N + ++ + TN L PE
Sbjct: 213 SWMAPEMIKKQPCNEKVDVYSFGVVLWEMLTRETPYANIAQMAIIFGVGTN-ILSLPMPE 271
Query: 830 YLSLEIKRFLSVCLCVDVKYRASTEELLHH 859
+ + CL + R S + H
Sbjct: 272 EAPKGLVLLIKQCLSQKGRNRPSFSHIRQH 301
>At3g04530 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 277
Score = 113 bits (283), Expect = 1e-24
Identities = 80/247 (32%), Positives = 126/247 (50%), Gaps = 12/247 (4%)
Query: 619 AEKNQLGNKVAIKQMILSKQPRKELIVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVME 678
A K K K++++ R+ + ++ H NI+ + Y +TED L +VME
Sbjct: 32 ATKEFYACKTIDKRVLIDALDRECIETEPRIMAMLPPHPNIIRIFDLY-ETEDSLAIVME 90
Query: 679 YMEGGSLTDIIENSPTGSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLL 738
++ I + + G+ L+E + A ++ L H ++HRD+K DNVL+
Sbjct: 91 LVDPPMT---IYDRLISAGGR--LSESESASYAKQILSALAHCHRCDVVHRDVKPDNVLV 145
Query: 739 D-TRGRVKITDFGFCAKLTDKRSKRATMVGTPYWMAPEVVKQREYDEKVDVWSLGIMTIE 797
D G VK+ DFG L + ++ +VGTPY++APEVV R+YDEKVD+WS G++
Sbjct: 146 DLVSGGVKLCDFGSAVWLGGETAEG--VVGTPYYVAPEVVMGRKYDEKVDIWSAGVVIYT 203
Query: 798 MLESEPPYLNEEPLKALYLIATNGTPKLKHPEY--LSLEIKRFLSVCLCVDVKYRASTEE 855
ML EPP+ N E + ++ G + ++ +S E K L +C DV R S E+
Sbjct: 204 MLAGEPPF-NGETAEDIFESILRGNLRFPPKKFGSVSSEAKDLLRKMICRDVSRRFSAED 262
Query: 856 LLHHSFF 862
L S F
Sbjct: 263 ALRKSSF 269
>HsM4505103 [R] KOG0586 Serine/threonine protein kinase
Length = 713
Score = 113 bits (282), Expect = 1e-24
Identities = 88/334 (26%), Positives = 155/334 (46%), Gaps = 37/334 (11%)
Query: 546 GDSNQQKTTEVSKKKPSKPAMSNAEIMTNLKNVTFNMDPTPFFRMVEKAGQGASGSVYLA 605
GD Q+ T+ S+ S A ++ + +R+++ G+G V LA
Sbjct: 22 GDGRQEVTSRTSR--------SGARCRNSIASCADEQPHIGNYRLLKTIGKGNFAKVKLA 73
Query: 606 ERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKEL--IVNEILVMKDSKHNNIVNFL 663
+ G +VAIK + ++ L + E+ +MK H NIV
Sbjct: 74 RHILT--------------GREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLF 119
Query: 664 EAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAYIVRETCQGLKFLHD 723
E ++T+ L+++MEY GG + D + + E + R+ +++ H
Sbjct: 120 EV-IETQKTLYLIMEYASGGKVFDYLV-------AHGRMKEKEARSKFRQIVSAVQYCHQ 171
Query: 724 KHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMVGTPYWMAPEVVKQREYD 783
K I+HRD+K++N+LLD +KI DFGF + T K T G+P + APE+ + ++YD
Sbjct: 172 KRIVHRDLKAENLLLDADMNIKIADFGFSNEFT-VGGKLDTFCGSPPYAAPELFQGKKYD 230
Query: 784 -EKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTPKLKHPEYLSLEIKRFLSVC 842
+VDVWSLG++ ++ P+ + + LK L G K + P Y+S + + L
Sbjct: 231 GPEVDVWSLGVILYTLVSGSLPF-DGQNLKELRERVLRG--KYRIPFYMSTDCENLLKRF 287
Query: 843 LCVDVKYRASTEELLHHSFFNMSCESQDLISLLE 876
L ++ R + E+++ + N E +L +E
Sbjct: 288 LVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVE 321
>At5g01810 [T] KOG0583 Serine/threonine protein kinase
Length = 421
Score = 113 bits (282), Expect = 1e-24
Identities = 87/279 (31%), Positives = 139/279 (49%), Gaps = 28/279 (10%)
Query: 595 GQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKELIVNEILVMKDS 654
GQG VY A L+ + + KV K+ IL K E I EI M+
Sbjct: 19 GQGTFAKVYHARHLKTG----------DSVAIKVIDKERIL-KVGMTEQIKREISAMRLL 67
Query: 655 KHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAYIVRET 714
+H NIV E + T+ ++ VME+++GG L + + S+G+ L E ++
Sbjct: 68 RHPNIVELHEV-MATKSKIYFVMEHVKGGELFNKV------STGK--LREDVARKYFQQL 118
Query: 715 CQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRA---TMVGTPYW 771
+ + F H + + HRD+K +N+LLD G +KI+DFG A L+D R + T GTP +
Sbjct: 119 VRAVDFCHSRGVCHRDLKPENLLLDEHGNLKISDFGLSA-LSDSRRQDGLLHTTCGTPAY 177
Query: 772 MAPEVVKQREYDE-KVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTPKLKHPEY 830
+APEV+ + YD K DVWS G++ +L P+ + ++ L G ++K P +
Sbjct: 178 VAPEVISRNGYDGFKADVWSCGVILFVLLAGYLPFRDSNLME---LYKKIGKAEVKFPNW 234
Query: 831 LSLEIKRFLSVCLCVDVKYRASTEELLHHSFFNMSCESQ 869
L+ KR L L + R STE+++ S+F + +
Sbjct: 235 LAPGAKRLLKRILDPNPNTRVSTEKIMKSSWFRKGLQEE 273
>At2g32510 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 372
Score = 112 bits (281), Expect = 2e-24
Identities = 82/276 (29%), Positives = 135/276 (48%), Gaps = 36/276 (13%)
Query: 595 GQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKELIVNEILVMKDS 654
G+G++ +VY A DE+ A K+ S+ R E + E ++
Sbjct: 10 GRGSTATVYAAAGHN----SDEILAVKS-------------SEVHRSEFLQREAKILSSL 52
Query: 655 KHNNIVNFLEAYLKTEDDLWVV----MEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAYI 710
++ + + K E + V+ MEY G+LTD + + E ++
Sbjct: 53 SSPYVIGYRGSETKRESNGVVMYNLLMEYAPYGTLTD------AAAKDGGRVDETRVVKY 106
Query: 711 VRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMVGTPY 770
R+ +GL+++H K I+H D+K NV++ +G KI DFG CAK D + M GTP
Sbjct: 107 TRDILKGLEYIHSKGIVHCDVKGSNVVISEKGEAKIADFG-CAKRVDPVFESPVM-GTPA 164
Query: 771 WMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYL----NEEPLKALYLIA-TNGTPKL 825
+MAPEV + + ++ D+W++G IEM+ PP+ E+P+ LY + ++ TP+L
Sbjct: 165 FMAPEVARGEKQGKESDIWAVGCTMIEMVTGSPPWTKADSREDPVSVLYRVGYSSETPEL 224
Query: 826 KHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSF 861
P L+ E K FL CL + R + +LL+H F
Sbjct: 225 --PCLLAEEAKDFLEKCLKREANERWTATQLLNHPF 258
>7301734 [T] KOG0694 Serine/threonine protein kinase
Length = 739
Score = 112 bits (281), Expect = 2e-24
Identities = 66/218 (30%), Positives = 113/218 (51%), Gaps = 18/218 (8%)
Query: 588 FRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKELIVNE 647
F ++ G+G+ G V LAE+ DE+ A K +K+ + + + + E
Sbjct: 408 FNFIKVLGKGSFGKVMLAEKKGT----DEIYAIK-------VLKKDAIIQDDDVDCTMTE 456
Query: 648 ILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQI 707
++ + ++ + L + +T D L+ VMEY+ GG L I+ + + ++
Sbjct: 457 KRILALAANHPFLTALHSCFQTPDRLFFVMEYVNGGDLMFQIQKARRFEASRA------- 509
Query: 708 AYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMVG 767
A+ E L+FLH +I+RD+K DN+LLD G K+ DFG C + T G
Sbjct: 510 AFYAAEVTLALQFLHTHGVIYRDLKLDNILLDQEGHCKLADFGMCKEGIMNGMLTTTFCG 569
Query: 768 TPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPY 805
TP ++APE++K++EY VD W+LG++ EM+ +PP+
Sbjct: 570 TPDYIAPEILKEQEYGASVDWWALGVLMYEMMAGQPPF 607
>Hs4506057 [T] KOG0616 cAMP-dependent protein kinase catalytic subunit (PKA)
Length = 351
Score = 112 bits (279), Expect = 3e-24
Identities = 74/286 (25%), Positives = 140/286 (48%), Gaps = 25/286 (8%)
Query: 565 AMSNAEIMTNLKNVTFNMDPTPFFRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQL 624
A + + + +N T N F + G G+ G V L + +A +
Sbjct: 21 AKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVMLVKH----------KATEQYY 70
Query: 625 GNKVAIKQMILSKQPRKELIVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGS 684
K+ KQ ++ K + E +NE +++ +V LE K +L++VMEY+ GG
Sbjct: 71 AMKILDKQKVV-KLKQIEHTLNEKRILQAVNFPFLVR-LEYAFKDNSNLYMVMEYVPGGE 128
Query: 685 LTDIIENSPTGSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRV 744
+ + +EP + + ++LH +I+RD+K +N+L+D +G +
Sbjct: 129 MFSHLRRI-------GRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYI 181
Query: 745 KITDFGFCAKLTDKRSKRATMVGTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPP 804
++TDFGF ++ + + T+ GTP ++APE++ + Y++ VD W+LG++ EM PP
Sbjct: 182 QVTDFGFAKRV---KGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPP 238
Query: 805 YLNEEPLKALYLIATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYR 850
+ ++P++ I + K++ P + S ++K L L VD+ R
Sbjct: 239 FFADQPIQIYEKIVSG---KVRFPSHFSSDLKDLLRNLLQVDLTKR 281
>CE17284 [T] KOG0583 Serine/threonine protein kinase
Length = 726
Score = 112 bits (279), Expect = 3e-24
Identities = 85/283 (30%), Positives = 137/283 (48%), Gaps = 32/283 (11%)
Query: 587 FFRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKEL--I 644
F+ + ++ G G G V LA L KVAIK +I KQ +L +
Sbjct: 10 FYAVHDELGSGGFGKVRLATHLLT--------------NQKVAIK-IIDKKQLGHDLPRV 54
Query: 645 VNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTE 704
E+ +++ H NI L Y++TED ++VMEY GG + D I + L E
Sbjct: 55 QTEMDALRNLSHQNICR-LYHYIETEDKFFIVMEYCSGGEMFDYIVR-------KERLEE 106
Query: 705 PQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKR-- 762
+ + R+ + F+H + HRD+K +N+LL +K+ DFG CAK R +
Sbjct: 107 SEARHFFRQLVSAIAFVHSQGYAHRDLKPENLLLTEDLHLKLIDFGLCAKTEKGRIDKHN 166
Query: 763 -ATMVGTPYWMAPEVVKQREY-DEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATN 820
T G+P + APE+++ +Y + DVWS+GI+ +L P+ ++ ++ +Y +
Sbjct: 167 LDTCCGSPAYAAPELIQGLQYKGNEADVWSMGILLYTLLVGALPF-EDDNMQIMYKKIQS 225
Query: 821 GTPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSFFN 863
G PE+LS K+ L L V + R S ++LL H + N
Sbjct: 226 GC--FYEPEFLSPLSKQLLRAMLQVVPERRISVKKLLEHDWLN 266
>At5g55090 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 448
Score = 112 bits (279), Expect = 3e-24
Identities = 80/217 (36%), Positives = 117/217 (53%), Gaps = 16/217 (7%)
Query: 659 IVNFLEAYLKTEDDLWV---VMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAYIVRETC 715
IV ++ + + E+D + +MEY+ GGSL D+I+NS G+ P EP I R+
Sbjct: 59 IVKYIGSNVTKENDKLMYNLLMEYVSGGSLHDLIKNS----GGKLP--EPLIRSYTRQIL 112
Query: 716 QGLKFLHDKHIIHRDIKSDNVLLDTRGRV-KITDFGFCAKLTDKRSKRATMVGTPYWMAP 774
+GL +LHD+ I+H D+KS NV++ G + KI D G CAK T + ++ GTP +M+P
Sbjct: 113 KGLMYLHDQGIVHCDVKSQNVMIG--GEIAKIVDLG-CAK-TVEENENLEFSGTPAFMSP 168
Query: 775 EVVKQREYDEKVDVWSLGIMTIEMLESEPPYLN-EEPLKALYLIATNGTPKLKHPEYLSL 833
EV + E DVW+LG IEM P+ + + A+Y I G + P +LS
Sbjct: 169 EVARGEEQSFPADVWALGCTVIEMATGSSPWPELNDVVAAIYKIGFTGESPV-IPVWLSE 227
Query: 834 EIKRFLSVCLCVDVKYRASTEELLHHSFFNMSCESQD 870
+ + FL CL D K R + EELL H F + D
Sbjct: 228 KGQDFLRKCLRKDPKQRWTVEELLQHPFLDEEDNDSD 264
>At2g17700 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 546
Score = 112 bits (279), Expect = 3e-24
Identities = 69/215 (32%), Positives = 110/215 (51%), Gaps = 17/215 (7%)
Query: 647 EILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQ 706
E+ +M+ +H N+V FL A ++ L +V E+M GS+ D + Q+ L
Sbjct: 331 EVFIMRKVRHKNVVQFLGACTRSPT-LCIVTEFMARGSIYDFLHKQKCAFKLQTLLK--- 386
Query: 707 IAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMV 766
+ + +G+ +LH +IIHRD+K+ N+L+D G VK+ DFG A++ +
Sbjct: 387 ---VALDVAKGMSYLHQNNIIHRDLKTANLLMDEHGLVKVADFG-VARVQIESGVMTAET 442
Query: 767 GTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNG----T 822
GT WMAPEV++ + Y+ K DV+S I+ E+L + PY PL+A + G
Sbjct: 443 GTYRWMAPEVIEHKPYNHKADVFSYAIVLWELLTGDIPYAFLTPLQAAVGVVQKGLRPKI 502
Query: 823 PKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELL 857
PK HP ++K L C D + R EE++
Sbjct: 503 PKKTHP-----KVKGLLERCWHQDPEQRPLFEEII 532
>YGL180w [OUT] KOG0595 Serine/threonine-protein kinase involved in autophagy
Length = 897
Score = 111 bits (278), Expect = 4e-24
Identities = 84/302 (27%), Positives = 135/302 (43%), Gaps = 49/302 (16%)
Query: 613 YKDELEAEKNQLGNKVAIKQMILSKQPRKELIVN---EILVMKDSKHNNIVNFLEAYLKT 669
Y+ L ++K+Q VAIK++ +K K+L+ N EI ++K KH +IV ++ +T
Sbjct: 39 YRGHLTSDKSQ---HVAIKEVSRAKLKNKKLLENLEIEIAILKKIKHPHIVGLIDCE-RT 94
Query: 670 EDDLWVVMEYMEGGSLT-----------------DIIENSPTGSSGQSPLTEPQIAYIVR 712
D +++MEY G LT + E P S + L + ++
Sbjct: 95 STDFYLIMEYCALGDLTFLLKRRKELMENHPLLRTVFEKYPPPSENHNGLHRAFVLSYLQ 154
Query: 713 ETCQGLKFLHDKHIIHRDIKSDNVLLDTR---------------------GRVKITDFGF 751
+ LKFL K+++HRDIK N+LL T +KI DFGF
Sbjct: 155 QLASALKFLRSKNLVHRDIKPQNLLLSTPLIGYHDSKSFHELGFVGIYNLPILKIADFGF 214
Query: 752 CAKLTDKRSKRATMVGTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPL 811
A+ S T+ G+P +MAPE++ ++Y+ K D+WS+G + EM PP+ L
Sbjct: 215 -ARFLPNTSLAETLCGSPLYMAPEILNYQKYNAKADLWSVGTVVFEMCCGTPPFRASNHL 273
Query: 812 KALYLIATNGTPKLKHPEYLSL--EIKRFLSVCLCVDVKYRASTEELLHHSFFNMSCESQ 869
+ L+ + P Y ++ E+K + L D R EE + N S
Sbjct: 274 E-LFKKIKRANDVITFPSYCNIEPELKELICSLLTFDPAQRIGFEEFFANKVVNEDLSSY 332
Query: 870 DL 871
+L
Sbjct: 333 EL 334
>HsM4826916 [D] KOG0575 Polo-like serine/threonine protein kinase
Length = 603
Score = 111 bits (278), Expect = 4e-24
Identities = 70/242 (28%), Positives = 122/242 (49%), Gaps = 12/242 (4%)
Query: 621 KNQLGNKVAIKQMILSKQPRKELIVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYM 680
K K+ K ++L R+++ + EI + + H ++V F + + D ++VV+E
Sbjct: 76 KEVFAGKIVPKSLLLKPHQREKMSM-EISIHRSLAHQHVVGF-HGFFEDNDFVFVVLELC 133
Query: 681 EGGSLTDIIENSPTGSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDT 740
SL + + + LTEP+ Y +R+ G ++LH +IHRD+K N+ L+
Sbjct: 134 RRRSLLEPHKR-------RKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNE 186
Query: 741 RGRVKITDFGFCAKLTDKRSKRATMVGTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLE 800
VKI DFG K+ ++ T+ GTP ++APEV+ ++E+ +VDVWS+G + +L
Sbjct: 187 DLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKEHSFEVDVWSIGCIMYTLLV 246
Query: 801 SEPPYLNEEPLKALYLIATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHS 860
+PP+ LK YL + P++++ + L D R + ELL+
Sbjct: 247 GKPPF-ETSCLKETYLRIKKNEYSI--PKHINPVAASLIQKMLQTDPTARPTINELLNDE 303
Query: 861 FF 862
FF
Sbjct: 304 FF 305
>Hs4506055 [T] KOG0616 cAMP-dependent protein kinase catalytic subunit (PKA)
Length = 351
Score = 111 bits (278), Expect = 4e-24
Identities = 70/263 (26%), Positives = 132/263 (49%), Gaps = 25/263 (9%)
Query: 588 FRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKELIVNE 647
F ++ G G+ G V L + + N K+ KQ ++ K + E +NE
Sbjct: 44 FERIKTLGTGSFGRVMLVKHKETG----------NHYAMKILDKQKVV-KLKQIEHTLNE 92
Query: 648 ILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQI 707
+++ +V LE K +L++VMEY+ GG + + +EP
Sbjct: 93 KRILQAVNFPFLVK-LEFSFKDNSNLYMVMEYVPGGEMFSHLRRI-------GRFSEPHA 144
Query: 708 AYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMVG 767
+ + ++LH +I+RD+K +N+L+D +G +++TDFGF ++ + + T+ G
Sbjct: 145 RFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV---KGRTWTLCG 201
Query: 768 TPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTPKLKH 827
TP ++APE++ + Y++ VD W+LG++ EM PP+ ++P++ I + K++
Sbjct: 202 TPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG---KVRF 258
Query: 828 PEYLSLEIKRFLSVCLCVDVKYR 850
P + S ++K L L VD+ R
Sbjct: 259 PSHFSSDLKDLLRNLLQVDLTKR 281
>CE24761 [D] KOG0580 Serine/threonine protein kinase
Length = 305
Score = 111 bits (278), Expect = 4e-24
Identities = 78/282 (27%), Positives = 132/282 (46%), Gaps = 24/282 (8%)
Query: 588 FRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKELIVNE 647
F + G+G GSVYLA + + KV K ++S +L E
Sbjct: 30 FEIGRPLGKGKFGSVYLART----------KTGHFHVAIKVLFKSQLISGGVEHQL-ERE 78
Query: 648 ILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQI 707
I + H NI+ L Y +++V+EY GG + + S S EP
Sbjct: 79 IEIQSHLNHPNIIK-LYTYFWDAKKIYLVLEYAPGGEMYKQLTVSKRFS-------EPTA 130
Query: 708 AYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMVG 767
A + E L + H K++IHRDIK +N+L+ ++G +KI DFG+ +KR TM G
Sbjct: 131 AKYMYEIADALSYCHRKNVIHRDIKPENLLIGSQGELKIGDFGWSVHAPS--NKRQTMCG 188
Query: 768 TPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTPKLKH 827
T ++ PE+V ++ + VD+W++G++ E L +PP+ +E+ K I + +
Sbjct: 189 TMDYLPPEMVNGADHSDAVDLWAIGVLCYEFLVGKPPFEHEDQSKTYAAIK---AARFTY 245
Query: 828 PEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSFFNMSCESQ 869
P+ + + + L VD K R + E++ H + E++
Sbjct: 246 PDSVKKGARDLIGRLLVVDPKARCTLEQVKEHYWIQGMMEAK 287
>At5g39440 [T] KOG0583 Serine/threonine protein kinase
Length = 494
Score = 111 bits (278), Expect = 4e-24
Identities = 82/283 (28%), Positives = 140/283 (48%), Gaps = 33/283 (11%)
Query: 586 PFFRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKEL-- 643
P +R+ + G G+ V LA + G+KVAIK IL++ K +
Sbjct: 17 PNYRIGKTLGHGSFAKVKLALHVAT--------------GHKVAIK--ILNRSKIKNMGI 60
Query: 644 ---IVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQS 700
+ EI +++ H +I+ E ++T +D++VVMEY++ G L D I +
Sbjct: 61 EIKVQREIKILRFLMHPHIIRQYEV-IETPNDIYVVMEYVKSGELFDYIVE-------KG 112
Query: 701 PLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRS 760
L E + ++ ++ G+++ H I+HRD+K +NVLLD++ +KI DFG + D
Sbjct: 113 KLQEDEARHLFQQIISGVEYCHRNMIVHRDLKPENVLLDSQCNIKIVDFGLSNVMHDGHF 172
Query: 761 KRATMVGTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATN 820
+ T G+P + APEV+ + Y VD+WS G++ +L P+ ++E + ++
Sbjct: 173 LK-TSCGSPNYAAPEVISGKPYGPDVDIWSCGVILYALLCGTLPF-DDENIPNVFEKIKR 230
Query: 821 GTPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSFFN 863
G L P +LS + + L VD R S E+ H +FN
Sbjct: 231 GMYTL--PNHLSHFARDLIPRMLMVDPTMRISITEIRQHPWFN 271
>At2g42630 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 357
Score = 111 bits (278), Expect = 4e-24
Identities = 74/238 (31%), Positives = 123/238 (51%), Gaps = 15/238 (6%)
Query: 621 KNQLGNKVAIKQMILSKQPRKELIVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYM 680
K ++ K+ + Q + ++ + + NEI ++ +H N++ L A K L +V EYM
Sbjct: 125 KTEVAIKIFLGQQLTAENMK--VFCNEISILSRLQHPNVILLLGACTKPPQ-LSLVTEYM 181
Query: 681 EGGSLTDIIENSPTGSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDT 740
GSL D+I S Q L I+ E C+GL ++H I+HRD+ S N LL+
Sbjct: 182 STGSLYDVIRTRKKELSWQRKLK------ILAEICRGLMYIHKMGIVHRDLTSANCLLN- 234
Query: 741 RGRVKITDFGFCAKLTDKRSKRATMVGTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLE 800
+ VKI DFG ++T K GTP WMAPE+++ EK D++S G++ E+
Sbjct: 235 KSIVKICDFGLSRRMTGTAVKDTEAAGTPEWMAPELIRNEPVTEKSDIFSFGVIMWELST 294
Query: 801 SEPPYLNEEPLKALYLIATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLH 858
P+ K ++++A G +LK PE +++ ++ C + + R S +E+LH
Sbjct: 295 LSKPWKGVPKEKVIHIVANEGA-RLKIPEG---PLQKLIADCWS-EPEQRPSCKEILH 347
>Hs7662210 [OUT] KOG0595 Serine/threonine-protein kinase involved in autophagy
Length = 1036
Score = 111 bits (277), Expect = 6e-24
Identities = 73/245 (29%), Positives = 115/245 (46%), Gaps = 19/245 (7%)
Query: 627 KVAIKQMILSKQPRKELIVN-EILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSL 685
+VAIK + + ++++ EI ++K+ +H NIV + + + +++VMEY GG L
Sbjct: 35 EVAIKSINKKNLSKSQILLGKEIKILKELQHENIVALYDVQ-ELPNSVFLVMEYCNGGDL 93
Query: 686 TDIIENSPTGSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGR-- 743
D ++ T L+E I + + ++ LH K IIHRD+K N+LL R
Sbjct: 94 ADYLQAKGT-------LSEDTIRVFLHQIAAAMRILHSKGIIHRDLKPQNILLSYANRRK 146
Query: 744 -------VKITDFGFCAKLTDKRSKRATMVGTPYWMAPEVVKQREYDEKVDVWSLGIMTI 796
+KI DFGF A+ AT+ G+P +MAPEV+ + YD K D+WS+G +
Sbjct: 147 SSVSGIRIKIADFGF-ARYLHSNMMAATLCGSPMYMAPEVIMSQHYDAKADLWSIGTVIY 205
Query: 797 EMLESEPPYLNEEPLKALYLIATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEEL 856
+ L +PP+ P N + P S + L L + K R E
Sbjct: 206 QCLVGKPPFQANSPQDLRMFYEKNRSLMPSIPRETSPYLANLLLGLLQRNQKDRMDFEAF 265
Query: 857 LHHSF 861
H F
Sbjct: 266 FSHPF 270
>CE21879 [D] KOG0590 Checkpoint kinase and related serine/threonine protein
kinases
Length = 328
Score = 111 bits (277), Expect = 6e-24
Identities = 85/277 (30%), Positives = 140/277 (49%), Gaps = 31/277 (11%)
Query: 588 FRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRK--ELIV 645
F+ ++ G+GA G V+LAE+L P K VA+K++ + P++ E I
Sbjct: 6 FKPIKSIGKGAFGQVFLAEKLNNPRIK-------------VAMKKINIFGAPKEFLEQIQ 52
Query: 646 NEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEP 705
E + K+ KH NIV + TE ++ E++ GG L + I+ ++ +
Sbjct: 53 QEYYIQKNMKHKNIVKMYGMSMDTEF-CYLFQEFVTGGDLFEKIDF-------ENGMPVN 104
Query: 706 QIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAK--LTDKRSKRA 763
Q+ +++ GLK++H I+HRDIK DN+L+++ +KI DFG + + DK
Sbjct: 105 QVKGYLKQLMSGLKYIHGCGIVHRDIKPDNLLINSSDALKIADFGLSTRFIVDDKEILLH 164
Query: 764 TMVGTPYWMAPEV-VKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIA---T 819
+GT +MAPE+ K++ VD+WS GI+ +L P+ +EP ++ L +
Sbjct: 165 ERIGTTPFMAPELFAKKKHRGPPVDIWSAGILVFSLLTGNLPW--DEPKESDILYSQWMN 222
Query: 820 NGTPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEEL 856
N T K LS + RFL L +V RA+ EE+
Sbjct: 223 NKTSKNCIWYGLSTPVVRFLKKLLKENVNERATIEEI 259
>Hs21359873 [D] KOG0575 Polo-like serine/threonine protein kinase
Length = 603
Score = 110 bits (276), Expect = 7e-24
Identities = 69/242 (28%), Positives = 122/242 (49%), Gaps = 12/242 (4%)
Query: 621 KNQLGNKVAIKQMILSKQPRKELIVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYM 680
K K+ K ++L R+++ + EI + + H ++V F + + D ++VV+E
Sbjct: 76 KEVFAGKIVPKSLLLKPHQREKMSM-EISIHRSLAHQHVVGF-HGFFEDNDFVFVVLELC 133
Query: 681 EGGSLTDIIENSPTGSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDT 740
SL ++ + + LTEP+ Y +R+ G ++LH +IHRD+K N+ L+
Sbjct: 134 RRRSLLELHKR-------RKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNE 186
Query: 741 RGRVKITDFGFCAKLTDKRSKRATMVGTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLE 800
VKI DFG K+ ++ T+ GTP ++APEV+ ++ + +VDVWS+G + +L
Sbjct: 187 DLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLV 246
Query: 801 SEPPYLNEEPLKALYLIATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHS 860
+PP+ LK YL + P++++ + L D R + ELL+
Sbjct: 247 GKPPF-ETSCLKETYLRIKKNEYSI--PKHINPVAASLIQKMLQTDPTARPTINELLNDE 303
Query: 861 FF 862
FF
Sbjct: 304 FF 305
>Hs14777335 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 795
Score = 110 bits (276), Expect = 7e-24
Identities = 73/242 (30%), Positives = 122/242 (50%), Gaps = 11/242 (4%)
Query: 625 GNKVAIKQMILSKQPRKELIVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGS 684
G +A K + + +E + NEI +M H N++ +A+ +++ +VMEY++GG
Sbjct: 514 GLPLAAKIIKVKSAKDREDVKNEINIMNQLSHVNLIQLYDAF-ESKHSCTLVMEYVDGGE 572
Query: 685 LTDIIENSPTGSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLL--DTRG 742
L D I + + LTE + R+ C+G+ +LH +I+H D+K +N+L T
Sbjct: 573 LFDRITDE------KYHLTELDVVLFTRQICEGVHYLHQHYILHLDLKPENILCVNQTGH 626
Query: 743 RVKITDFGFCAKLTDKRSKRATMVGTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESE 802
++KI DFG A+ R K GTP ++APEVV D+WS+G++T +L
Sbjct: 627 QIKIIDFGL-ARRYKPREKLKVNFGTPEFLAPEVVNYEFVSFPTDMWSVGVITYMLLSGL 685
Query: 803 PPYLNEEPLKAL-YLIATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSF 861
P+L E + + +++ + E LS E K F+S L + R S + L H +
Sbjct: 686 SPFLGETDAETMNFIVNCSWDFDADTFEGLSEEAKDFVSRLLVKEKSCRMSATQCLKHEW 745
Query: 862 FN 863
N
Sbjct: 746 LN 747
>At4g26070 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 354
Score = 110 bits (276), Expect = 7e-24
Identities = 70/206 (33%), Positives = 106/206 (50%), Gaps = 14/206 (6%)
Query: 675 VVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAYIVRETCQGLKFLH-DKHIIHRDIKS 733
+++E+M+GGSL D+++ G+ P E ++ I + +GL ++H ++ IIHRD+K
Sbjct: 141 IILEFMDGGSLADLLKKV-----GKVP--ENMLSAICKRVLRGLCYIHHERRIIHRDLKP 193
Query: 734 DNVLLDTRGRVKITDFGFCAKLTDKRSKRATMVGTPYWMAPEVVKQREYDEKVDVWSLGI 793
N+L++ RG VKITDFG LT S + VGT +M+PE + Y K D+WSLG+
Sbjct: 194 SNLLINHRGEVKITDFGVSKILTSTSSLANSFVGTYPYMSPERISGSLYSNKSDIWSLGL 253
Query: 794 MTIEMLESEPPYLNEEPLKA------LYLIATNGTPKLKHPEYLSLEIKRFLSVCLCVDV 847
+ +E + PY E K L P S E F+S C+ D
Sbjct: 254 VLLECATGKFPYTPPEHKKGWSSVYELVDAIVENPPPCAPSNLFSPEFCSFISQCVQKDP 313
Query: 848 KYRASTEELLHHSFFNMSCESQDLIS 873
+ R S +ELL H F M +S +S
Sbjct: 314 RDRKSAKELLEHKFVKMFEDSDTNLS 339
>7297542 [T] KOG0616 cAMP-dependent protein kinase catalytic subunit (PKA)
Length = 353
Score = 110 bits (276), Expect = 7e-24
Identities = 67/263 (25%), Positives = 135/263 (50%), Gaps = 25/263 (9%)
Query: 588 FRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKELIVNE 647
F ++ G G+ G V + + + K+ K+ KQ ++ K + E +NE
Sbjct: 46 FERIKTLGTGSFGRVMIVQH----------KPTKDYYAMKILDKQKVV-KLKQVEHTLNE 94
Query: 648 ILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQI 707
+++ + +V+ L + K +L++V+EY+ GG + + +EP
Sbjct: 95 KRILQAIQFPFLVS-LRYHFKDNSNLYMVLEYVPGGEMFSHLRKV-------GRFSEPHS 146
Query: 708 AYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMVG 767
+ + ++LH +I+RD+K +N+L+D++G +K+TDFGF ++ + + T+ G
Sbjct: 147 RFYAAQIVLAFEYLHYLDLIYRDLKPENLLIDSQGYLKVTDFGFAKRV---KGRTWTLCG 203
Query: 768 TPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTPKLKH 827
TP ++APE++ + Y++ VD W+LG++ EM PP+ ++P++ I + K++
Sbjct: 204 TPEYLAPEIILSKGYNKAVDWWALGVLVYEMAAGYPPFFADQPIQIYEKIVSG---KVRF 260
Query: 828 PEYLSLEIKRFLSVCLCVDVKYR 850
P + ++K L L VD+ R
Sbjct: 261 PSHFGSDLKDLLRNLLQVDLTKR 283
>7293496 [R] KOG0597 Serine-threonine protein kinase FUSED
Length = 805
Score = 110 bits (276), Expect = 7e-24
Identities = 86/272 (31%), Positives = 133/272 (48%), Gaps = 34/272 (12%)
Query: 595 GQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPR--KEL--IVNEILV 650
GQG+ G VY A R KD+ + VAIK ++SK+ R KEL + E +
Sbjct: 11 GQGSFGCVYKATR------KDDSKV--------VAIK--VISKRGRATKELKNLRRECDI 54
Query: 651 MKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIEN-SPTGSSGQSPLTEPQIAY 709
KH +++ +E++ +++ DL+VV E+ +L D+ S G+ G+ P
Sbjct: 55 QARLKHPHVIEMIESF-ESKTDLFVVTEF----ALMDLHRYLSYNGAMGEEPARR----- 104
Query: 710 IVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMVGTP 769
+ L +LH I+HRD+K NVLLD K+ DFG +T ++ GTP
Sbjct: 105 VTGHLVSALYYLHSNRILHRDLKPQNVLLDKNMHAKLCDFGLARNMTLGTHVLTSIKGTP 164
Query: 770 YWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTPKLKHPE 829
+MAPE++ ++ YD D+WSLG + E + +PP+ L+L+ +K P
Sbjct: 165 LYMAPELLAEQPYDHHADMWSLGCIAYESMAGQPPFCAS---SILHLVKMIKHEDVKWPS 221
Query: 830 YLSLEIKRFLSVCLCVDVKYRASTEELLHHSF 861
L+ E + FL L D R S +LL H F
Sbjct: 222 TLTSECRSFLQGLLEKDPGLRISWTQLLCHPF 253
>7292679 [G] KOG0599 Phosphorylase kinase gamma subunit
Length = 560
Score = 110 bits (276), Expect = 7e-24
Identities = 69/225 (30%), Positives = 119/225 (52%), Gaps = 17/225 (7%)
Query: 647 EILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQ 706
EI +++ + + L+ +++ +++V E G L D + + T L+E +
Sbjct: 77 EISILRQVMGHPYIIDLQDVFESDAFVFLVFELCPKGELFDYLTSVVT-------LSEKK 129
Query: 707 IAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMV 766
I+R+ +G++++H K I+HRD+K +N+LLD VKITDFGF AK + K +
Sbjct: 130 TRTIMRQIFEGVEYIHAKSIVHRDLKPENILLDENHNVKITDFGF-AKQLQEGEKLTNLC 188
Query: 767 GTPYWMAPEVVK------QREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATN 820
GTP ++APE +K Y ++VD+W+ G++ +L PP+ + + + L I
Sbjct: 189 GTPGYLAPETLKCNMFEGSPGYSQEVDIWACGVIMFTLLVGCPPFWHRKQMVMLRNI-ME 247
Query: 821 GTPKLKHPEY--LSLEIKRFLSVCLCVDVKYRASTEELLHHSFFN 863
G PE+ +S + K + CL VD R + +E+L H FFN
Sbjct: 248 GKYSFTSPEWADISEDPKDLIRKCLVVDPSQRITVKEVLRHPFFN 292
>Hs4507273 [D] KOG0580 Serine/threonine protein kinase
Length = 275
Score = 110 bits (275), Expect = 9e-24
Identities = 72/218 (33%), Positives = 110/218 (50%), Gaps = 21/218 (9%)
Query: 588 FRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKELIVNE 647
F + G+G G+VYLA L+ + KV K I K+ + + E
Sbjct: 9 FEIGRPLGKGKFGNVYLAR----------LKESHFIVALKVLFKSQI-EKEGLEHQLRRE 57
Query: 648 ILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQI 707
I + +H NI+ L Y +++++EY G L ++ S L E +
Sbjct: 58 IEIQAHLQHPNILR-LYNYFHDARRVYLILEYAPRGELYKELQKS-------EKLDEQRT 109
Query: 708 AYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMVG 767
A I+ E L + HDK +IHRDIK +N+LL RG VKI DFG+ + +R TM G
Sbjct: 110 ATIIEEVADALTYCHDKKVIHRDIKPENLLLGFRGEVKIADFGW--SVHTPLPERKTMCG 167
Query: 768 TPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPY 805
T ++ PE+++ R YDEKVD+W +G++ E+L PP+
Sbjct: 168 TLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPF 205
>7295638 [T] KOG0603 Ribosomal protein S6 kinase
Length = 911
Score = 110 bits (275), Expect = 9e-24
Identities = 98/365 (26%), Positives = 163/365 (43%), Gaps = 47/365 (12%)
Query: 499 VTTSQNKQPSPS---QSAAQMAMRQHNQHP-----AGMPKVANAKLQPAREAPRVGDSNQ 550
VT+SQ +Q QSA Q A+ QH+ P + + + L P E + DS
Sbjct: 88 VTSSQRRQQLQQVQQQSALQAALEQHHISPTADLDSARKRPTHRTLCPPPELMELSDSES 147
Query: 551 QKTTEVSKKKP-----SKPAMSNAEIMTNLKNVTFNM-----------DPTPFFRMVEKA 594
Q E ++ S P + + E + +N F + DP+ F ++
Sbjct: 148 QGGVETGGRREGATGRSAPDLEDTEPLYETEN-EFELKEVIKEGHDKADPSQF-ELLRVL 205
Query: 595 GQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKELIVNEILVMKDS 654
G+G+ G V+L ++ + + L +K+ L + R NE ++ D
Sbjct: 206 GEGSFGKVFLVRKI--------IGKDAGTLYAMKVLKKATLKVKDRVRS-TNERKILADV 256
Query: 655 KHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAYIVRET 714
H IV A+ +T L+++++++ GG L T S + TE + + + E
Sbjct: 257 GHAFIVRLHYAF-QTPGKLYLILDFLRGGDLF-------TRLSKEVMFTEEDVKFYLAEL 308
Query: 715 CQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMVGTPYWMAP 774
+ LH II+RD+K +N+LLD G + +TDFG + D SK + GT +MAP
Sbjct: 309 ALAMNHLHTLGIIYRDLKPENILLDEHGHIALTDFGLSKQPLD-GSKTYSFCGTVEYMAP 367
Query: 775 EVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTPKLKHPEYLSLE 834
E+V ++ +D D WS G++ EML P+ + + + I + KL PE LS E
Sbjct: 368 EIVNRKGHDFAADWWSFGVLMYEMLTGNLPFHGQTRQETMNQILRS---KLGMPENLSPE 424
Query: 835 IKRFL 839
+ L
Sbjct: 425 AQSLL 429
Score = 79.3 bits (194), Expect = 2e-14
Identities = 55/221 (24%), Positives = 103/221 (45%), Gaps = 16/221 (7%)
Query: 649 LVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIA 708
++++ H NIV Y + ++VME ++GG L D I + GQ + E + +
Sbjct: 621 IMLRYGNHPNIVTLYSVY-EDAGSAYLVMELLKGGELLDRIL-----AVGQ--MCESEAS 672
Query: 709 YIVRETCQGLKFLHDKHIIHRDIKSDNVLL----DTRGRVKITDFGFCAKLTDKRSKRAT 764
++R + +LH+ ++HRD+K N++ T +K+ D GF +L T
Sbjct: 673 AVLRTIASAVAYLHEHGVVHRDLKPSNMIYASMRQTPETLKLCDLGFAKQLRADNGLLMT 732
Query: 765 MVGTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTPK 824
T ++APEV+K++ YD D+WSLG++ ML P+ + ++ G+ +
Sbjct: 733 PCYTANFVAPEVLKRQGYDLACDIWSLGVLLYIMLSGRTPFASTPNDSPDVILKRIGSGQ 792
Query: 825 LKHPE----YLSLEIKRFLSVCLCVDVKYRASTEELLHHSF 861
+ +S+ K L L + + R + +L H +
Sbjct: 793 IDFTSSRWALISVPAKELLRQMLHIVPENRPTAARILEHDW 833
>CE13014 [T] KOG0603 Ribosomal protein S6 kinase
Length = 740
Score = 110 bits (274), Expect = 1e-23
Identities = 83/314 (26%), Positives = 147/314 (46%), Gaps = 27/314 (8%)
Query: 555 EVSKKKPSKPAMSNAEI-MTNLKNVTFNMDPTPFFRMVEKAGQGASGSVYLAERLQLPPY 613
E+ + + + S EI + +++ DP F +++ GQG+ G V+L +++
Sbjct: 14 EIEQGEEKTDSSSETEIDIGDVRKCGEKADPRQF-ELLKVLGQGSFGKVFLVRKVR---G 69
Query: 614 KDELEAEKNQLGNKVAIKQMILSKQPRKELIVNEILVMKDSKHNNIVNFLEAYLKTEDDL 673
+D ++ K +K + + R +L N ++ H IV A+ +TE L
Sbjct: 70 RDSGHVYAMKVLKKATLK---VRDRQRTKLERN---ILAHISHPFIVKLHYAF-QTEGKL 122
Query: 674 WVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKS 733
+++++++ GG L T S + TE + + + E L+ LH I++RD+K
Sbjct: 123 YLILDFLRGGDLF-------TRLSKEVMFTEDDVKFYLAELTLALEHLHSLGIVYRDLKP 175
Query: 734 DNVLLDTRGRVKITDFGFCAKLTDKRSKRATMVGTPYWMAPEVVKQREYDEKVDVWSLGI 793
+N+LLD G +K+TDFG + D K + GT +MAPEV+ +R + D WSLG+
Sbjct: 176 ENILLDADGHIKVTDFGLSKEAIDSEKKTYSFCGTVEYMAPEVINRRGHSMAADFWSLGV 235
Query: 794 MTIEMLESEPPYLNEEPLKALYLIATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYRA-- 851
+ EML P+ + + I KL P +L+ E + L + + R
Sbjct: 236 LMFEMLTGHLPFQGRDRNDTMTQIL---KAKLSMPHFLTQEAQSLLRALFKRNSQNRLGA 292
Query: 852 ---STEELLHHSFF 862
EE+ H+FF
Sbjct: 293 GPDGVEEIKRHAFF 306
Score = 95.5 bits (236), Expect = 3e-19
Identities = 71/286 (24%), Positives = 135/286 (46%), Gaps = 34/286 (11%)
Query: 585 TPFFRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKELI 644
T + ++EK G GA V+ K +++A + + K+ +K+ + +++
Sbjct: 394 TDDYEILEKIGNGAHSVVH----------KCQMKATRRKYAVKI-VKKAVFDATEEVDIL 442
Query: 645 VNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTE 704
++ S H +V + Y + E ++++ E EGG L D + N + S E
Sbjct: 443 ------LRHSHHQFVVKLFDVY-EDETAIYMIEELCEGGELLDKLVNKKSLGS------E 489
Query: 705 PQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTR----GRVKITDFGFCAKLTDKRS 760
++A I+ +++LH + + HRD+ + N+L + ++I DFGF + +
Sbjct: 490 KEVAAIMANLLNAVQYLHSQQVAHRDLTAANILFALKDGDPSSLRIVDFGFAKQSRAENG 549
Query: 761 KRATMVGTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYL---NEEPLKALYLI 817
T T ++APEV++++ YD DVWSLG++ ML P+ N+ P + L +
Sbjct: 550 MLMTPCYTAQFVAPEVLRKQGYDRSCDVWSLGVLLHTMLTGCTPFAMGPNDTPDQILQRV 609
Query: 818 ATNGTPKLKHP--EYLSLEIKRFLSVCLCVDVKYRASTEELLHHSF 861
+G + HP + +S E K + L VD R + ++ L H +
Sbjct: 610 G-DGKISMTHPVWDTISDEAKDLVRKMLDVDPNRRVTAKQALQHKW 654
>7304311 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 405
Score = 110 bits (274), Expect = 1e-23
Identities = 86/292 (29%), Positives = 146/292 (49%), Gaps = 49/292 (16%)
Query: 595 GQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRK---ELIVNEILVM 651
G GA V LAE K+ G A+K I+ K+ K E + NEI V+
Sbjct: 38 GTGAFSEVRLAE-------------SKDSPGEHFAVK--IIDKKALKGKEESLENEIRVL 82
Query: 652 K-------DSK--------HNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGS 696
+ D K H NIV LE Y + + +++VME + GG L D I
Sbjct: 83 RRFSANHFDGKCLNGTRLTHPNIVQLLETY-EDKSKVYLVMELVTGGELFDRIVE----- 136
Query: 697 SGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLL---DTRGRVKITDFGFCA 753
+ TE ++++R+ + + ++H++ ++HRD+K +N+L D ++ I+DFG +
Sbjct: 137 --KGSYTEKDASHLIRQILEAVDYMHEQGVVHRDLKPENLLYYSPDDDSKIMISDFGL-S 193
Query: 754 KLTDKRSKRATMVGTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKA 813
K+ D AT GTP ++APEV+ Q+ Y + VDVWS+G+++ +L PP+ +E
Sbjct: 194 KMEDS-GIMATACGTPGYVAPEVLAQKPYGKAVDVWSIGVISYILLCGYPPFYDENDAN- 251
Query: 814 LYLIATNGTPKLKHP--EYLSLEIKRFLSVCLCVDVKYRASTEELLHHSFFN 863
L+ G + P + +S K F+ +CV V+ R + ++ L H++ +
Sbjct: 252 LFAQILKGDFEFDSPYWDEISESAKHFIKNLMCVTVEKRYTCKQALGHAWIS 303
>7298652 [D] KOG0615 Serine/threonine protein kinase Chk2 and related
proteins
Length = 459
Score = 110 bits (274), Expect = 1e-23
Identities = 80/252 (31%), Positives = 127/252 (49%), Gaps = 23/252 (9%)
Query: 623 QLGNKVAIKQMILSKQPRKEL-----IVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVM 677
Q K+ K M+ +P ++NE +MK+ H +V + K D +++V+
Sbjct: 182 QFAMKIVKKNMLSGARPSTNFSDPDRVLNEAKIMKNLSHPCVVRMHDIVDKP-DSVYMVL 240
Query: 678 EYMEGGSLTDIIENSPTGSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVL 737
E+M GG L + I ++ S S L Q+ C +K+LHD+ I HRD+K DNVL
Sbjct: 241 EFMRGGDLLNRIISNKLLSEDISKLYFYQM-------CHAVKYLHDRGITHRDLKPDNVL 293
Query: 738 LDTRGR---VKITDFGFCAKLTDKRSKRATMVGTPYWMAPEVV---KQREYDEKVDVWSL 791
L+T +K++DFG +K K S T+ GTP ++APEV+ + Y +KVD+WSL
Sbjct: 294 LETNDEETLLKVSDFGL-SKFVQKDSVMRTLCGTPLYVAPEVLITGGREAYTKKVDIWSL 352
Query: 792 GIMTIEMLESEPPYLNEEPLKALYLIATNGTPKLKHPEY--LSLEIKRFLSVCLCVDVKY 849
G++ L P+ +E A I G HP + +S K ++ L VD +
Sbjct: 353 GVVLFTCLSGTLPFSDEYGTPAAQQI-KKGRFAYGHPSWKSVSQRAKLLINQMLIVDPER 411
Query: 850 RASTEELLHHSF 861
R S +++L S+
Sbjct: 412 RPSIDDVLQSSW 423
>Hs7019489 [T] KOG0694 Serine/threonine protein kinase
Length = 889
Score = 109 bits (273), Expect = 2e-23
Identities = 98/399 (24%), Positives = 163/399 (40%), Gaps = 49/399 (12%)
Query: 471 IPPRMHPQRIASDRSQNQPKPGMQPLIQVTTSQNKQPSPSQSAAQMAMRQHNQHPAGMPK 530
+PP P I+ + + ++ T N P + +M P P+
Sbjct: 462 LPPCSSPSTISPPKGCPRTPTTLREASDPATPSNFLPKKTPLGEEMTP------PPKPPR 515
Query: 531 VANAKLQPAREAPRVGDSNQQKTTEVSKKKPSKPAMSNAEIMTNLKNVTFNMDPTPFFRM 590
+ + + E PR + + T P+ P + FR
Sbjct: 516 LYLPQEPTSEETPRTKRPHMEPRTRRGPSPPASPTRKPPRLQD--------------FRC 561
Query: 591 VEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKELIVNEILV 650
+ G+G G V L + + K KQ +LS+ + L + ++
Sbjct: 562 LAVLGRGHFGKVLLVQ----------FKGTGKYYAIKALKKQEVLSRDEIESLYCEKRIL 611
Query: 651 --MKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIA 708
+ + H +++ L + +T V E++ GG L I + EPQ
Sbjct: 612 EAVGCTGHPFLLSLLVCF-QTSSHARFVTEFVPGGDLMMQIH--------EDVFPEPQAR 662
Query: 709 YIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMVGT 768
+ V GL+FLH+K II+RD+K DN+LLD +G +KI DFG C + + +T GT
Sbjct: 663 FYVACVVLGLQFLHEKKIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFCGT 722
Query: 769 PYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTPKLKHP 828
P ++APEV+ Q Y + VD W+LG++ EML E P+ + + I P +P
Sbjct: 723 PEFLAPEVLTQEAYTQAVDWWALGVLLYEMLVGECPFPGDTEEEVFDCIVNMDAP---YP 779
Query: 829 EYLSLEIKRFLSVCL--CVDVKYRA---STEELLHHSFF 862
+LS++ F+ L C + + A EE+ FF
Sbjct: 780 GFLSVQGLEFIQKLLQKCPEKRLGAGEQDAEEIKVQPFF 818
>Hs6031180 [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and related
serine/threonine protein kinases
Length = 1558
Score = 109 bits (273), Expect = 2e-23
Identities = 85/305 (27%), Positives = 139/305 (44%), Gaps = 42/305 (13%)
Query: 575 LKNVTFNMDPTPFFRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMI 634
L+ VTF ++ K G+G G VY + G +A+K++
Sbjct: 1286 LRKVTFK------WQRGNKIGEGQYGKVYTCISVDT--------------GELMAMKEIR 1325
Query: 635 LSKQPRKEL--IVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENS 692
K + +E+ + + KH N+V + L E+ +++ MEY + G+L ++
Sbjct: 1326 FQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREE-MYIFMEYCDEGTLEEV---- 1380
Query: 693 PTGSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFC 752
+ L E I ++ + LH+ I+HRDIK N+ L + G +K+ DFG
Sbjct: 1381 -----SRLGLQEHVIRLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCS 1435
Query: 753 AKLTDKRSKRA----TMVGTPYWMAPEVV---KQREYDEKVDVWSLGIMTIEMLESEPPY 805
KL + + +GT +MAPEV+ K + D+WSLG + IEM+ + P+
Sbjct: 1436 VKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPW 1495
Query: 806 LN-EEPLKALYLIATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSFFNM 864
E + +Y + P + PE LS E K FLS CL D K R + +LL HSF +
Sbjct: 1496 HEYEHNFQIMYKVGMGHKPPI--PERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKV 1553
Query: 865 SCESQ 869
+ +
Sbjct: 1554 CTDEE 1558
>Hs5803088 [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and related
serine/threonine protein kinases
Length = 1607
Score = 109 bits (273), Expect = 2e-23
Identities = 85/305 (27%), Positives = 139/305 (44%), Gaps = 42/305 (13%)
Query: 575 LKNVTFNMDPTPFFRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMI 634
L+ VTF ++ K G+G G VY + G +A+K++
Sbjct: 1335 LRKVTFK------WQRGNKIGEGQYGKVYTCISVDT--------------GELMAMKEIR 1374
Query: 635 LSKQPRKEL--IVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENS 692
K + +E+ + + KH N+V + L E+ +++ MEY + G+L ++
Sbjct: 1375 FQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREE-MYIFMEYCDEGTLEEV---- 1429
Query: 693 PTGSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFC 752
+ L E I ++ + LH+ I+HRDIK N+ L + G +K+ DFG
Sbjct: 1430 -----SRLGLQEHVIRLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCS 1484
Query: 753 AKLTDKRSKRA----TMVGTPYWMAPEVV---KQREYDEKVDVWSLGIMTIEMLESEPPY 805
KL + + +GT +MAPEV+ K + D+WSLG + IEM+ + P+
Sbjct: 1485 VKLKNNAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPW 1544
Query: 806 LN-EEPLKALYLIATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSFFNM 864
E + +Y + P + PE LS E K FLS CL D K R + +LL HSF +
Sbjct: 1545 HEYEHNFQIMYKVGMGHKPPI--PERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKV 1602
Query: 865 SCESQ 869
+ +
Sbjct: 1603 CTDEE 1607
>Hs5453976 [T] KOG0694 Serine/threonine protein kinase
Length = 706
Score = 109 bits (273), Expect = 2e-23
Identities = 73/252 (28%), Positives = 127/252 (49%), Gaps = 21/252 (8%)
Query: 588 FRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKELIVNE 647
F + + G+G+ G V+LAE +K + NQ A+K+ ++ E + E
Sbjct: 380 FILHKMLGKGSFGKVFLAE------FK-----KTNQFFAIKALKKDVVLMDDDVECTMVE 428
Query: 648 ILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQI 707
V+ + + + + +T+++L+ VMEY+ GG L I++ ++
Sbjct: 429 KRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRA------- 481
Query: 708 AYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMVG 767
+ E GL+FLH K I++RD+K DN+LLD G +KI DFG C + +K T G
Sbjct: 482 TFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFCG 541
Query: 768 TPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTPKLKH 827
TP ++APE++ ++Y+ VD WS G++ EML + P+ ++ + + I + +
Sbjct: 542 TPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNP---FY 598
Query: 828 PEYLSLEIKRFL 839
P +L E K L
Sbjct: 599 PRWLEKEAKDLL 610
>Hs14196445 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 476
Score = 109 bits (273), Expect = 2e-23
Identities = 86/293 (29%), Positives = 138/293 (46%), Gaps = 32/293 (10%)
Query: 576 KNVTFNMDPTPFFRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMIL 635
K T N+ T F +E G GA V+L ++ G A+K +
Sbjct: 13 KKQTTNIRKT--FIFMEVLGSGAFSEVFLVKQ--------------RLTGKLFALKCIKK 56
Query: 636 SKQPRKELIVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTG 695
S R + NEI V+K KH NIV + Y T ++VM+ + GG L D I
Sbjct: 57 SPAFRDSSLENEIAVLKKIKHENIVTLEDIYESTTH-YYLVMQLVSGGELFDRILE---- 111
Query: 696 SSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDT---RGRVKITDFGFC 752
+ TE + ++++ +K+LH+ I+HRD+K +N+L T ++ ITDFG
Sbjct: 112 ---RGVYTEKDASLVIQQVLSAVKYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLS 168
Query: 753 AKLTDKRSKRATMVGTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLK 812
++ +T GTP ++APEV+ Q+ Y + VD WS+G++T +L PP+ E K
Sbjct: 169 KM--EQNGIMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVITYILLCGYPPFYEETESK 226
Query: 813 ALYLIATNGTPKLKHP--EYLSLEIKRFLSVCLCVDVKYRASTEELLHHSFFN 863
L+ G + + P + +S K F+ L D R + E+ L H + +
Sbjct: 227 -LFEKIKEGYYEFESPFWDDISESAKDFICHLLEKDPNERYTCEKALSHPWID 278
>CE18169 [T] KOG0603 Ribosomal protein S6 kinase
Length = 797
Score = 109 bits (273), Expect = 2e-23
Identities = 77/280 (27%), Positives = 133/280 (47%), Gaps = 25/280 (8%)
Query: 588 FRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKELIVNE 647
F +++ GQG+ G V+L +++ +D ++ K +K + + R +L N
Sbjct: 104 FELLKVLGQGSFGKVFLVRKVR---GRDSGHVYAMKVLKKATLK---VRDRQRTKLERN- 156
Query: 648 ILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQI 707
++ H IV A+ +TE L+++++++ GG L T S + TE +
Sbjct: 157 --ILAHISHPFIVKLHYAF-QTEGKLYLILDFLRGGDLF-------TRLSKEVMFTEDDV 206
Query: 708 AYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMVG 767
+ + E L+ LH I++RD+K +N+LLD G +K+TDFG + D K + G
Sbjct: 207 KFYLAELTLALEHLHSLGIVYRDLKPENILLDADGHIKVTDFGLSKEAIDSEKKTYSFCG 266
Query: 768 TPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTPKLKH 827
T +MAPEV+ +R + D WSLG++ EML P+ + + I KL
Sbjct: 267 TVEYMAPEVINRRGHSMAADFWSLGVLMFEMLTGHLPFQGRDRNDTMTQIL---KAKLSM 323
Query: 828 PEYLSLEIKRFLSVCLCVDVKYRA-----STEELLHHSFF 862
P +L+ E + L + + R EE+ H+FF
Sbjct: 324 PHFLTQEAQSLLRALFKRNSQNRLGAGPDGVEEIKRHAFF 363
Score = 95.5 bits (236), Expect = 3e-19
Identities = 71/286 (24%), Positives = 135/286 (46%), Gaps = 34/286 (11%)
Query: 585 TPFFRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKELI 644
T + ++EK G GA V+ K +++A + + K+ +K+ + +++
Sbjct: 451 TDDYEILEKIGNGAHSVVH----------KCQMKATRRKYAVKI-VKKAVFDATEEVDIL 499
Query: 645 VNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTE 704
++ S H +V + Y + E ++++ E EGG L D + N + S E
Sbjct: 500 ------LRHSHHQFVVKLFDVY-EDETAIYMIEELCEGGELLDKLVNKKSLGS------E 546
Query: 705 PQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTR----GRVKITDFGFCAKLTDKRS 760
++A I+ +++LH + + HRD+ + N+L + ++I DFGF + +
Sbjct: 547 KEVAAIMANLLNAVQYLHSQQVAHRDLTAANILFALKDGDPSSLRIVDFGFAKQSRAENG 606
Query: 761 KRATMVGTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYL---NEEPLKALYLI 817
T T ++APEV++++ YD DVWSLG++ ML P+ N+ P + L +
Sbjct: 607 MLMTPCYTAQFVAPEVLRKQGYDRSCDVWSLGVLLHTMLTGCTPFAMGPNDTPDQILQRV 666
Query: 818 ATNGTPKLKHP--EYLSLEIKRFLSVCLCVDVKYRASTEELLHHSF 861
+G + HP + +S E K + L VD R + ++ L H +
Sbjct: 667 G-DGKISMTHPVWDTISDEAKDLVRKMLDVDPNRRVTAKQALQHKW 711
>Hs20070247_2 [RT] KOG0598 Ribosomal protein S6 kinase and related proteins
Length = 378
Score = 109 bits (273), Expect = 2e-23
Identities = 63/218 (28%), Positives = 114/218 (51%), Gaps = 18/218 (8%)
Query: 588 FRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKELIVNE 647
F ++ G+G+ G V LA+R + + KV K+++L+++ +K ++
Sbjct: 44 FDFLKVIGKGSFGKVLLAKR----------KLDGKVYAVKVLQKKIVLNRKEQKHIMAER 93
Query: 648 ILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQI 707
+++K+ KH +V L +T + L+ V++++ GG L ++ + E +
Sbjct: 94 NVLLKNVKHPFLVG-LHYSFQTTEKLYFVLDFVNGGELFFHLQR-------ERSFPEHRA 145
Query: 708 AYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMVG 767
+ E L +LH I++RD+K +N+L+D+ G V +TDFG C + T G
Sbjct: 146 RFYAAEIASALGYLHSIKIVYRDLKPENILVDSVGHVVLTDFGLCKEGIAISDTTTTFCG 205
Query: 768 TPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPY 805
TP ++APEV++++ YD VD W LG + EML PP+
Sbjct: 206 TPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPF 243
>Hs4506101 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 438
Score = 109 bits (272), Expect = 2e-23
Identities = 102/325 (31%), Positives = 151/325 (46%), Gaps = 48/325 (14%)
Query: 544 RVGDSNQQKTTEVSKKKPSKPAM-SNAEIMTNLKNVTFNMDPTPFFRMVEKAGQGASGSV 602
R G S Q + VS PS S+AE+ L N N R + G G G+V
Sbjct: 125 RAGPS-QHSSPAVSDSLPSNSLKKSSAELKKILANGQMNEQD---IRYRDTLGHGNGGTV 180
Query: 603 YLAERLQLPPYKDELEAEKNQLGNKVAIKQMILS------KQPRKELIVNEILVMKDSKH 656
Y A + G +A+K ++L KQ EL EIL DS +
Sbjct: 181 YKAYHVPS--------------GKILAVKVILLDITLELQKQIMSEL---EILYKCDSSY 223
Query: 657 NNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAYIVRETCQ 716
I+ F A+ E+ + + E+M+GGSL D+ P E + I +
Sbjct: 224 --IIGFYGAFF-VENRISICTEFMDGGSL-DVYRKMP----------EHVLGRIAVAVVK 269
Query: 717 GLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMVGTPYWMAPEV 776
GL +L I+HRD+K N+L++TRG+VK+ DFG +L + +K T VGT +MAPE
Sbjct: 270 GLTYLWSLKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAK--TYVGTNAYMAPER 327
Query: 777 VKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTPKLKHPEYLSLEIK 836
+ +Y DVWSLGI +E+ +++ + PL+ L I +P L E+ S
Sbjct: 328 ISGEQYGIHSDVWSLGISFMEIQKNQGSLM---PLQLLQCIVDEDSPVLPVGEF-SEPFV 383
Query: 837 RFLSVCLCVDVKYRASTEELLHHSF 861
F++ C+ K R + EEL+ H F
Sbjct: 384 HFITQCMRKQPKERPAPEELMGHPF 408
>Hs21729897 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 467
Score = 109 bits (272), Expect = 2e-23
Identities = 102/325 (31%), Positives = 151/325 (46%), Gaps = 48/325 (14%)
Query: 544 RVGDSNQQKTTEVSKKKPSKPAM-SNAEIMTNLKNVTFNMDPTPFFRMVEKAGQGASGSV 602
R G S Q + VS PS S+AE+ L N N R + G G G+V
Sbjct: 125 RAGPS-QHSSPAVSDSLPSNSLKKSSAELKKILANGQMNEQD---IRYRDTLGHGNGGTV 180
Query: 603 YLAERLQLPPYKDELEAEKNQLGNKVAIKQMILS------KQPRKELIVNEILVMKDSKH 656
Y A + G +A+K ++L KQ EL EIL DS +
Sbjct: 181 YKAYHVPS--------------GKILAVKVILLDITLELQKQIMSEL---EILYKCDSSY 223
Query: 657 NNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAYIVRETCQ 716
I+ F A+ E+ + + E+M+GGSL D+ P E + I +
Sbjct: 224 --IIGFYGAFF-VENRISICTEFMDGGSL-DVYRKMP----------EHVLGRIAVAVVK 269
Query: 717 GLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMVGTPYWMAPEV 776
GL +L I+HRD+K N+L++TRG+VK+ DFG +L + +K T VGT +MAPE
Sbjct: 270 GLTYLWSLKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAK--TYVGTNAYMAPER 327
Query: 777 VKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTPKLKHPEYLSLEIK 836
+ +Y DVWSLGI +E+ +++ + PL+ L I +P L E+ S
Sbjct: 328 ISGEQYGIHSDVWSLGISFMEIQKNQGSLM---PLQLLQCIVDEDSPVLPVGEF-SEPFV 383
Query: 837 RFLSVCLCVDVKYRASTEELLHHSF 861
F++ C+ K R + EEL+ H F
Sbjct: 384 HFITQCMRKQPKERPAPEELMGHPF 408
>CE27583 [T] KOG0604 MAP kinase-activated protein kinase 2
Length = 425
Score = 109 bits (272), Expect = 2e-23
Identities = 99/336 (29%), Positives = 158/336 (46%), Gaps = 49/336 (14%)
Query: 542 APRVGDSNQQKTTEVSKKKPSKPAMSNAEIMTNLKNVTFNMDPTPFFRMVEKA-GQGASG 600
A R+G K++ K KP M+ E T +R+ K G G +G
Sbjct: 36 ANRIGCCLSTKSSPAEKIKPPDEIMAFHEYPV-----------TQDYRISRKVLGVGING 84
Query: 601 SVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKELIVNEILVMKDSKHNNIV 660
V +E E Q G+K A+K + +++ R+E+ E+ VM S H ++V
Sbjct: 85 KV--------------VECEHRQSGDKFALKVLRDTQKARREV---ELHVMA-SGHGHVV 126
Query: 661 NFLEAYLKTE---DDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAYIVRETCQG 717
+ + Y + D L VVME M+GG L + I+ GQ TE + A IV E C
Sbjct: 127 SVHDVYKNSYNGVDCLLVVMENMKGGELFNRIQER-----GQKAFTEREAAGIVNEICSA 181
Query: 718 LKFLHDKHIIHRDIKSDNVLLDT---RGRVKITDFGFCAKLTDKRSKRA--TMVGTPYWM 772
+ LH I HRD+K +N+L T +K+TDFGF AK TD+ + T TPY+
Sbjct: 182 VAHLHRMSIAHRDLKPENLLYVTTASNAALKLTDFGF-AKKTDESEPQGLKTACFTPYYC 240
Query: 773 APEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNE--EPLK-ALYLIATNGTPKLKHPE 829
APEV+ +YD+ D+WS+G++ +L PP+ ++ +P+ + +G PE
Sbjct: 241 APEVLGTEKYDKSCDLWSIGVIMYILLCGYPPFYSQHGQPMSPGMKAKIKSGQYTFPSPE 300
Query: 830 Y--LSLEIKRFLSVCLCVDVKYRASTEELLHHSFFN 863
+ +S K + L + R + E+ + H + +
Sbjct: 301 WDCVSEAAKDLIRKLLRTEPTERITIEQTMEHKWIS 336
>SPBC106.10 [T] KOG0616 cAMP-dependent protein kinase catalytic subunit (PKA)
Length = 512
Score = 108 bits (271), Expect = 3e-23
Identities = 82/284 (28%), Positives = 135/284 (46%), Gaps = 30/284 (10%)
Query: 588 FRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKELIVNE 647
F ++ G G+ G V+L + Y EK ++ V +KQ+ E +E
Sbjct: 201 FNFLQTLGTGSFGRVHLVQSNHNRLYYAIKVLEKKKI---VDMKQI--------EHTCDE 249
Query: 648 ILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQI 707
++ +H + L + +L++VM++ EGG L ++ E
Sbjct: 250 RYILSRVQHP-FITILWGTFQDAKNLFMVMDFAEGGELFSLLRKCHR-------FPEKVA 301
Query: 708 AYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMVG 767
+ E L +LH I++RD+K +N+LLD G +KI DFGF +++ S T+ G
Sbjct: 302 KFYAAEVILALDYLHHNQIVYRDLKPENLLLDRFGHLKIVDFGFAKRVST--SNCCTLCG 359
Query: 768 TPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTPKLKH 827
TP ++APE++ + Y++ D WSLGI+ EML PP+ +E P+K LY G K+ +
Sbjct: 360 TPDYLAPEIISLKPYNKAADWWSLGILIFEMLAGYPPFYSENPMK-LYENILEG--KVNY 416
Query: 828 PEYLSLEIKRFLSVCLCVDVKYR------ASTEELLHHSFFNMS 865
P Y S LS L D+ R S + ++H F ++S
Sbjct: 417 PSYFSPASIDLLSHLLQRDITCRYGNLKDGSMDIIMHPWFRDIS 460
>Hs21729895 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 448
Score = 108 bits (271), Expect = 3e-23
Identities = 104/332 (31%), Positives = 150/332 (44%), Gaps = 52/332 (15%)
Query: 544 RVGDSNQQKTTEVSKKKPSKPAM-SNAEIMTNLKNVTFNMDPTPFFRMVEKAGQGASGSV 602
R G S Q + VS PS S+AE+ L N N R + G G G+V
Sbjct: 125 RAGPS-QHSSPAVSDSLPSNSLKKSSAELKKILANGQMNEQD---IRYRDTLGHGNGGTV 180
Query: 603 YLAERLQLPPYKDELEAEKNQLGNKVAIKQMILS------KQPRKELIVNEILVMKDSKH 656
Y A + G +A+K ++L KQ EL EIL DS +
Sbjct: 181 YKAYHVPS--------------GKILAVKVILLDITLELQKQIMSEL---EILYKCDSSY 223
Query: 657 NNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAYIVRETCQ 716
I+ F A+ E+ + + E+M+GGSL D+ P E + I +
Sbjct: 224 --IIGFYGAFF-VENRISICTEFMDGGSL-DVYRKMP----------EHVLGRIAVAVVK 269
Query: 717 GLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMVGTPYWMAPEV 776
GL +L I+HRD+K N+L++TRG+VK+ DFG +L + +K T VGT +MAPE
Sbjct: 270 GLTYLWSLKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAK--TYVGTNAYMAPER 327
Query: 777 VKQREYDEKVDVWSLGIMTIEMLESEPPYLNEE-------PLKALYLIATNGTPKLKHPE 829
+ +Y DVWSLGI +E+ PY + PL+ L I +P L E
Sbjct: 328 ISGEQYGIHSDVWSLGISFMELALGRFPYPQIQKNQGSLMPLQLLQCIVDEDSPVLPVGE 387
Query: 830 YLSLEIKRFLSVCLCVDVKYRASTEELLHHSF 861
+ S F++ C+ K R + EEL+ H F
Sbjct: 388 F-SEPFVHFITQCMRKQPKERPAPEELMGHPF 418
>Hs14728804 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 576
Score = 108 bits (271), Expect = 3e-23
Identities = 68/227 (29%), Positives = 123/227 (53%), Gaps = 18/227 (7%)
Query: 640 RKELIVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQ 699
+++++ +EIL+++ H NIV E Y +T+ ++++++EY++GG L D I S
Sbjct: 323 KEDMVDSEILIIQSLSHPNIVKLHEVY-ETDMEIYLILEYVQGGDLFDAIIESVK----- 376
Query: 700 SPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLL----DTRGRVKITDFGFCAKL 755
EP A ++ + C+ L +HDK I+HRD+K +N+L+ D +K+ DFG +
Sbjct: 377 --FPEPDAALMIMDLCKALVHMHDKSIVHRDLKPENLLVQRNEDKSTTLKLADFGLAKHV 434
Query: 756 TDKRSKRATMVGTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLN-EEPLKAL 814
T+ GTP ++APE++ ++ Y +VD+W+ G++ +L PP+ + E L
Sbjct: 435 V---RPIFTVCGTPTYVAPEILSEKGYGLEVDMWAAGVILYILLCGFPPFRSPERDQDEL 491
Query: 815 YLIATNGTPKLKHP--EYLSLEIKRFLSVCLCVDVKYRASTEELLHH 859
+ I G + P + +S K +S L VD K R + ++L H
Sbjct: 492 FNIIQLGHFEFLPPYWDNISDAAKDLVSRLLVVDPKKRYTAHQVLQH 538
>CE17545 [T] KOG0604 MAP kinase-activated protein kinase 2
Length = 443
Score = 108 bits (271), Expect = 3e-23
Identities = 83/260 (31%), Positives = 135/260 (51%), Gaps = 23/260 (8%)
Query: 617 LEAEKNQLGNKVAIKQMILSKQPRKELIVNEILVMKDSKHNNIVNFLEAYLKTE---DDL 673
+E E Q G+K A+K + +++ R+E+ E+ VM S H ++V+ + Y + D L
Sbjct: 105 VECEHRQSGDKFALKVLRDTQKARREV---ELHVMA-SGHGHVVSVHDVYKNSYNGVDCL 160
Query: 674 WVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKS 733
VVME M+GG L + I+ GQ TE + A IV E C + LH I HRD+K
Sbjct: 161 LVVMENMKGGELFNRIQER-----GQKAFTEREAAGIVNEICSAVAHLHRMSIAHRDLKP 215
Query: 734 DNVLLDT---RGRVKITDFGFCAKLTDKRSKRA--TMVGTPYWMAPEVVKQREYDEKVDV 788
+N+L T +K+TDFGF AK TD+ + T TPY+ APEV+ +YD+ D+
Sbjct: 216 ENLLYVTTASNAALKLTDFGF-AKKTDESEPQGLKTACFTPYYCAPEVLGTEKYDKSCDL 274
Query: 789 WSLGIMTIEMLESEPPYLNE--EPLK-ALYLIATNGTPKLKHPEY--LSLEIKRFLSVCL 843
WS+G++ +L PP+ ++ +P+ + +G PE+ +S K + L
Sbjct: 275 WSIGVIMYILLCGYPPFYSQHGQPMSPGMKAKIKSGQYTFPSPEWDCVSEAAKDLIRKLL 334
Query: 844 CVDVKYRASTEELLHHSFFN 863
+ R + E+ + H + +
Sbjct: 335 RTEPTERITIEQTMEHKWIS 354
>7304283 [Z] KOG0613 Projectin/twitchin and related proteins
Length = 7175
Score = 108 bits (271), Expect = 3e-23
Identities = 71/275 (25%), Positives = 138/275 (49%), Gaps = 25/275 (9%)
Query: 588 FRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKELIVNE 647
+ ++E+ G GA G V+ + GN A K + +S K+LI E
Sbjct: 6138 YDILEEIGTGAFGVVH--------------RCRERSTGNIFAAKFIPVSHSVEKDLIRRE 6183
Query: 648 ILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQI 707
I +M H ++N +A+ + +D++ +++E++ GG L + I ++ +TE ++
Sbjct: 6184 IDIMNQLHHQKLINLHDAF-EDDDEMILILEFLSGGELFERI------TAEGYVMTEAEV 6236
Query: 708 AYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRG--RVKITDFGFCAKLTDKRSKRATM 765
+R+ C+G++ +H+++IIH DIK +N++ TR VK+ DFG +L + T
Sbjct: 6237 INYMRQICEGIRHMHEQNIIHLDIKPENIMCQTRSSTNVKLIDFGLATRLDPNEVVKIT- 6295
Query: 766 VGTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLI-ATNGTPK 824
GT + APE+V + D+W+ G+++ +L P+ + ++ L + A +
Sbjct: 6296 TGTAEFAAPEIVNREPVGFYTDMWATGVLSYVLLSGLSPFAGDNDVQTLKNVKACDWDFD 6355
Query: 825 LKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHH 859
++ +Y+S E K F+ L + + R + E L H
Sbjct: 6356 VESFKYISEEAKDFIRKLLVRNKEKRMTAHECLLH 6390
>SPAC9G1.02 [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and related
serine/threonine protein kinases
Length = 1401
Score = 108 bits (270), Expect = 4e-23
Identities = 71/255 (27%), Positives = 128/255 (49%), Gaps = 27/255 (10%)
Query: 623 QLGNKVAIKQMILSK----QPRKELIVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVME 678
+ G+ +A+K++ L + + I NE+ V++ H N+V + + E +++ ME
Sbjct: 1058 ETGDLLAVKEIKLQDSRTFRSTVDQIHNEMTVLERLNHPNVVTYYGVEVHREK-VYIFME 1116
Query: 679 YMEGGSLTDIIENSPTGSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLL 738
+ +GGSL D++ + E + V + +GL ++H +HI+HRDIK N+LL
Sbjct: 1117 FCQGGSLADLLAHGRIED-------ENVLKVYVVQLLEGLAYIHSQHILHRDIKPANILL 1169
Query: 739 DTRGRVKITDFGFC----------AKLTDKRSKRATMVGTPYWMAPEVV---KQREYDEK 785
D RG +K +DFG + D + + + GTP +MAPE++ K+ ++
Sbjct: 1170 DHRGMIKYSDFGSALYVSPPTDPEVRYEDIQPELQHLAGTPMYMAPEIILGTKKGDFG-A 1228
Query: 786 VDVWSLGIMTIEMLESEPPYLN-EEPLKALYLIATNGTPKLKHPEYLSLEIKRFLSVCLC 844
+D+WSLG + +EM+ P+ + +Y +A TP + E +S + F+ C
Sbjct: 1229 MDIWSLGCVILEMMTGSTPWSEMDNEWAIMYHVAAMHTPSIPQNEKISSLARDFIEQCFE 1288
Query: 845 VDVKYRASTEELLHH 859
D + R +LL H
Sbjct: 1289 RDPEQRPRAVDLLTH 1303
>Hs4758652 [R] KOG0593 Predicted protein kinase KKIAMRE
Length = 358
Score = 108 bits (270), Expect = 4e-23
Identities = 88/315 (27%), Positives = 142/315 (44%), Gaps = 53/315 (16%)
Query: 588 FRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPR--KELIV 645
+ + K G+G+ G V+ + G VAIK+ + S+ K++ +
Sbjct: 5 YEKIGKIGEGSYGVVF--------------KCRNRDTGQIVAIKKFLESEDDPVIKKIAL 50
Query: 646 NEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEP 705
EI ++K KH N+VN LE + + + L +V EY + L ++ Q + E
Sbjct: 51 REIRMLKQLKHPNLVNLLEVF-RRKRRLHLVFEYCDHTVLHEL-------DRYQRGVPEH 102
Query: 706 QIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATM 765
+ I +T Q + F H + IHRD+K +N+L+ +K+ DFGF LT
Sbjct: 103 LVKSITWQTLQAVNFCHKHNCIHRDVKPENILITKHSVIKLCDFGFARLLTGPSDYYTDY 162
Query: 766 VGTPYWMAPE-VVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLI------- 817
V T ++ +PE +V +Y VDVW++G + E+L P + + + LYLI
Sbjct: 163 VATRWYRSPELLVGDTQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDL 222
Query: 818 --------ATN---GTPKLKHPEYLS-LEIK---------RFLSVCLCVDVKYRASTEEL 856
+TN K+ PE + LE+K L CL +D R + E+L
Sbjct: 223 IPRHQQVFSTNQYFSGVKIPDPEDMEPLELKFPNISYPALGLLKGCLHMDPTERLTCEQL 282
Query: 857 LHHSFFNMSCESQDL 871
LHH +F E +DL
Sbjct: 283 LHHPYFENIREIEDL 297
>7302861 [T] KOG0696 Serine/threonine protein kinase
Length = 700
Score = 108 bits (270), Expect = 4e-23
Identities = 85/310 (27%), Positives = 137/310 (43%), Gaps = 28/310 (9%)
Query: 558 KKKPSKPAMSNAEIMTNLKNVTFNMDPTPFFRMVEKAGQGASGSVYLAERLQLPPYKDEL 617
++ K M N ++ N+ +M F V+ G+G+ G V LAER DEL
Sbjct: 343 RRPNEKRRMDNKDMPHNMSKR--DMIRAADFNFVKVIGKGSFGKVLLAERRGT----DEL 396
Query: 618 EAEKNQLGNKVAIKQMILSKQPRKELIVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVM 677
A K +++ ++ + EL +NE ++ S + + + +T D L+ VM
Sbjct: 397 YAVK-------VLRKDVIIQTDDMELPMNEKKILALSGRPPFLVSMHSCFQTMDRLFFVM 449
Query: 678 EYMEGGSLTDIIENSPTGSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVL 737
EY +GG L ++ E + E L FLH++ II+RD+K DN+L
Sbjct: 450 EYCKGGDLMYHMQQ-------YGRFKESVAIFYAVEVAIALFFLHERDIIYRDLKLDNIL 502
Query: 738 LDTRGRVKITDFGFCAKLTDKRSKRATMVGTPYWMAPEVVKQREYDEKVDVWSLGIMTIE 797
LD G VK+ DFG + +R T GTP +MAPE+V Y D WS G++ E
Sbjct: 503 LDGEGHVKLVDFGLSKEGVTERQTTRTFCGTPNYMAPEIVSYDPYSIAADWWSFGVLLFE 562
Query: 798 MLESEPPYLNEEPLKALYLIATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYRA-----S 852
+ + P+ ++ I K P++ S+E ++ L R +
Sbjct: 563 FMAGQAPFEGDDETTVFRNIKDK---KAVFPKHFSVEAMDIITSFLTKKPNNRLGAGRYA 619
Query: 853 TEELLHHSFF 862
+E+ H FF
Sbjct: 620 RQEITTHPFF 629
>7294537 [OUT] KOG0595 Serine/threonine-protein kinase involved in autophagy
Length = 835
Score = 108 bits (270), Expect = 4e-23
Identities = 79/250 (31%), Positives = 129/250 (51%), Gaps = 27/250 (10%)
Query: 628 VAIKQMILSKQPRKE-LIVNEILVMKDSK---HNNIVNFLEAYLKTEDDLWVVMEYMEGG 683
VAIK + Q + + L+ EI ++K+ H N+V L+ +++D + +VMEY GG
Sbjct: 35 VAIKCITKKGQLKTQNLLGKEIKILKELTELHHENVVALLDCK-ESQDCVSLVMEYCNGG 93
Query: 684 SLTDIIENSPTGSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLD---- 739
L D + S + L+E + + + +K L+ K I+HRD+K N+LL
Sbjct: 94 DLADYL-------SVKGTLSEDTVRLFLVQLAGAMKALYTKGIVHRDLKPQNILLSHNYG 146
Query: 740 ------TRGRVKITDFGFCAKLTDKRSKRATMVGTPYWMAPEVVKQREYDEKVDVWSLGI 793
++ +KI DFGF A+ ++ + AT+ G+P +MAPEV+ +YD K D+WSLG
Sbjct: 147 KTLPAPSKITLKIADFGF-ARFLNEGAMAATLCGSPMYMAPEVIMSLQYDSKADLWSLGT 205
Query: 794 MTIEMLESEPPYLNEEP--LKALYLIATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYRA 851
+ + L + P+ + P LK+ Y N PK+ P +S +++ L L + K R
Sbjct: 206 IVYQCLTGKAPFYAQTPNELKSYYEQNANLAPKI--PSGVSPDLRDLLLCLLRRNSKDRI 263
Query: 852 STEELLHHSF 861
S E H F
Sbjct: 264 SYESFFVHRF 273
>7293666 [D] KOG0575 Polo-like serine/threonine protein kinase
Length = 576
Score = 108 bits (270), Expect = 4e-23
Identities = 65/215 (30%), Positives = 115/215 (53%), Gaps = 18/215 (8%)
Query: 616 ELEAEKNQLGNKVAIKQMILSKQPRKELIVNEILVMKDSKHNNIVNFLEAYLKTEDDLWV 675
++E + G V+ K MI K +KE EI + + H NIV F Y + ++++
Sbjct: 44 DVETDDVFAGKIVSKKLMI--KHNQKEKTAQEITIHRSLNHPNIVKF-HNYFEDSQNIYI 100
Query: 676 VMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDN 735
V+E + S+ ++ + + +TE + Y + + QG+K+LHD IIHRD+K N
Sbjct: 101 VLELCKKRSMMELHKR-------RKSITEFECRYYIYQIIQGVKYLHDNRIIHRDLKLGN 153
Query: 736 VLLDTRGRVKITDFGFCAKLTDKRSKRATMVGTPYWMAPEVVKQREYDEKVDVWSLGIMT 795
+ L+ VKI DFG ++ + ++ T+ GTP ++APE++ ++ + +VD+WS+G +
Sbjct: 154 LFLNDLLHVKIGDFGLATRIEYEGERKKTLCGTPNYIAPEILTKKGHSFEVDIWSIGCVM 213
Query: 796 IEMLESEPPYLNEEPLKALYLIATNGTPKLKHPEY 830
+L +PP+ + LK Y K+K EY
Sbjct: 214 YTLLVGQPPF-ETKTLKDTY-------SKIKKCEY 240
>YDR122w [T] KOG0583 Serine/threonine protein kinase
Length = 1064
Score = 108 bits (269), Expect = 5e-23
Identities = 99/395 (25%), Positives = 174/395 (43%), Gaps = 59/395 (14%)
Query: 500 TTSQNKQPSPSQSAAQMAMRQHNQHPAGMPKVANAKLQPAREAPRVGDSN----QQKTTE 555
+ S + QPS A M + Q + N L P + + N +QK +
Sbjct: 25 SNSMHTQPSTMAPATLRMMGKSPQQQ----QQQNTPLMPPADIKYANNGNSHQAEQKERQ 80
Query: 556 V-----SKKKPSKPAMSNAEIMTNLKNVT--FNMDPTPFFRMVEKAGQGASGSVYLAERL 608
V S++ KP ++ +++ + + F+ + VE G G+ G V LA+
Sbjct: 81 VELEGKSRENAPKPNTTSQSRVSSSQGMPKQFHRKSLGDWEFVETVGAGSMGKVKLAKHR 140
Query: 609 -----------------------QLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKELIV 645
LPP K+E + + Q K K++ K+ +E +
Sbjct: 141 YTNEVCAVKIVNRATKAFLHKEQMLPPPKNEQDVLERQ---KKLEKEISRDKRTIREASL 197
Query: 646 NEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEP 705
+IL H +I E + +++ EY+ GG L D I + E
Sbjct: 198 GQILY-----HPHICRLFEM-CTLSNHFYMLFEYVSGGQLLDYIIQ-------HGSIREH 244
Query: 706 QIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATM 765
Q R L +LH +I+HRD+K +N+++ +KI DFG + + D R + T
Sbjct: 245 QARKFARGIASALIYLHANNIVHRDLKIENIMISDSSEIKIIDFGL-SNIYDSRKQLHTF 303
Query: 766 VGTPYWMAPEVVKQREY-DEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTPK 824
G+ Y+ APE++K Y +VDVWS G++ ++ + P+ ++E L+ G K
Sbjct: 304 CGSLYFAAPELLKANPYTGPEVDVWSFGVVLFVLVCGKVPF-DDENSSVLHEKIKQG--K 360
Query: 825 LKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHH 859
+++P++LS+E+ LS L VD K RA+ ++++ H
Sbjct: 361 VEYPQHLSIEVISLLSKMLVVDPKRRATLKQVVEH 395
>SPBC4F6.06 [T] KOG0583 Serine/threonine protein kinase
Length = 891
Score = 108 bits (269), Expect = 5e-23
Identities = 93/388 (23%), Positives = 177/388 (44%), Gaps = 41/388 (10%)
Query: 495 PLIQVTTSQNKQPSP----SQSAAQMAMRQHNQHPAGMPKVANAKLQPAREAPRVGDSNQ 550
P I+++ S N+ + QS + + P G+ + + P+ ++P G
Sbjct: 23 PKIKISDSPNRHHNLVDAFMQSPSYSTQPKSAVEPLGL-SFSPGYISPSSQSPHHGPVRS 81
Query: 551 QKTTEVSKKKPSKPAMSNAEIMTNLKNVTFNMDPTPFFRMV------EKAGQGASGSVYL 604
+ + PS+ + + + + + + P +++ + G G+ G V +
Sbjct: 82 PSSRKPLPASPSRTRDHSLRVPVSGHSYSADEKPRERRKVIGNYVLGKTIGAGSMGKVKV 141
Query: 605 AERLQ------------LPPYKDELEAEKNQLGNKVAIKQMILSKQPRKELIVNEILVMK 652
A L+ L P + +A + K A + + +E ++ +L
Sbjct: 142 AHHLKTGEQFAIKIVTRLHPDITKAKAAASAEATKAAQSEKNKEIRTVREAALSTLL--- 198
Query: 653 DSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAYIVR 712
+H I + Y+ T ++V E+++GG + D I + L E Q VR
Sbjct: 199 --RHPYICEARDVYI-TNSHYYMVFEFVDGGQMLDYIIS-------HGKLKEKQARKFVR 248
Query: 713 ETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMVGTPYWM 772
+ L +LH ++HRD+K +N+L+ G +KI DFG + L ++S+ T G+ Y+
Sbjct: 249 QIGSALSYLHQNSVVHRDLKIENILISKTGDIKIIDFGL-SNLYRRQSRLRTFCGSLYFA 307
Query: 773 APEVVKQREY-DEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTPKLKHPEYL 831
APE++ + Y +VDVWS GI+ ++ + P+ +++ + AL+ GT +++P YL
Sbjct: 308 APELLNAQPYIGPEVDVWSFGIVLYVLVCGKVPF-DDQNMSALHAKIKKGT--VEYPSYL 364
Query: 832 SLEIKRFLSVCLCVDVKYRASTEELLHH 859
S + K LS L D RA+ EE+L+H
Sbjct: 365 SSDCKGLLSRMLVTDPLKRATLEEVLNH 392
>Hs4506073 [T] KOG0694 Serine/threonine protein kinase
Length = 942
Score = 108 bits (269), Expect = 5e-23
Identities = 74/247 (29%), Positives = 118/247 (46%), Gaps = 20/247 (8%)
Query: 588 FRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKELIVNE 647
F+ + G+G G V L+E EL A K + + + S K ++
Sbjct: 615 FKFLAVLGRGHFGKVLLSEFRP----SGELFAIKALKKGDIVARDEVESLMCEKRILA-- 668
Query: 648 ILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQI 707
+ + H +VN + +T + + VMEY GG L I + +EP+
Sbjct: 669 --AVTSAGHPFLVNLFGCF-QTPEHVCFVMEYSAGGDLMLHIHSDV--------FSEPRA 717
Query: 708 AYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMVG 767
+ GL+FLH+ I++RD+K DN+LLDT G VKI DFG C + + +T G
Sbjct: 718 IFYSACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCG 777
Query: 768 TPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTPKLKH 827
TP ++APEV+ Y VD W LG++ EML E P+ ++ + I + ++++
Sbjct: 778 TPEFLAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVND---EVRY 834
Query: 828 PEYLSLE 834
P +LS E
Sbjct: 835 PRFLSAE 841
>Hs21361133 [R] KOG0586 Serine/threonine protein kinase
Length = 752
Score = 108 bits (269), Expect = 5e-23
Identities = 88/350 (25%), Positives = 159/350 (45%), Gaps = 46/350 (13%)
Query: 546 GDSNQQKTTEVSKKKPSKPAMSNAEIMTNLKNVTFNMDPTPFFRMVEKAGQGASGSVYLA 605
GD Q+ T+ S+ S A ++ + +R+++ G+G V LA
Sbjct: 22 GDGRQEVTSRTSR--------SGARCRNSIASCADEQPHIGNYRLLKTIGKGNFAKVKLA 73
Query: 606 ERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKEL--IVNEILVMKDSKHNNIVNFL 663
+ G +VAIK + ++ L + E+ +MK H NIV
Sbjct: 74 RHILT--------------GREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLF 119
Query: 664 EAYLKTEDDLWVVMEYMEGGSLTDII----------------ENSPTGSSGQSPLTEPQI 707
E ++TE L+++MEY GG + D + + G + + ++ +
Sbjct: 120 EV-IETEKTLYLIMEYASGGEVFDYLVAHGKMKEKEARSKFRQGCQAGQTIKVQVSFDLL 178
Query: 708 AYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMVG 767
+ + +++ H K I+HRD+K++N+LLD +KI DFGF + T K T G
Sbjct: 179 SLMFTFIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFT-VGGKLDTFCG 237
Query: 768 TPYWMAPEVVKQREYD-EKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTPKLK 826
+P + APE+ + ++YD +VDVWSLG++ ++ P+ + + LK L G K +
Sbjct: 238 SPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPF-DGQNLKELRERVLRG--KYR 294
Query: 827 HPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSFFNMSCESQDLISLLE 876
P Y+S + + L L ++ R + E+++ + N E +L +E
Sbjct: 295 IPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVE 344
>Hs14758219 [T] KOG0694 Serine/threonine protein kinase
Length = 942
Score = 108 bits (269), Expect = 5e-23
Identities = 74/247 (29%), Positives = 118/247 (46%), Gaps = 20/247 (8%)
Query: 588 FRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKELIVNE 647
F+ + G+G G V L+E EL A K + + + S K ++
Sbjct: 615 FKFLAVLGRGHFGKVLLSEFRP----SGELFAIKALKKGDIVARDEVESLMCEKRILA-- 668
Query: 648 ILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQI 707
+ + H +VN + +T + + VMEY GG L I + +EP+
Sbjct: 669 --AVTSAGHPFLVNLFGCF-QTPEHVCFVMEYSAGGDLMLHIHSDV--------FSEPRA 717
Query: 708 AYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMVG 767
+ GL+FLH+ I++RD+K DN+LLDT G VKI DFG C + + +T G
Sbjct: 718 IFYSACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCG 777
Query: 768 TPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTPKLKH 827
TP ++APEV+ Y VD W LG++ EML E P+ ++ + I + ++++
Sbjct: 778 TPEFLAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVND---EVRY 834
Query: 828 PEYLSLE 834
P +LS E
Sbjct: 835 PRFLSAE 841
>At5g45820 [T] KOG0583 Serine/threonine protein kinase
Length = 439
Score = 108 bits (269), Expect = 5e-23
Identities = 82/274 (29%), Positives = 133/274 (47%), Gaps = 32/274 (11%)
Query: 595 GQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKELI---VNEILVM 651
GQG VY A ++ G VAIK + K + LI EI VM
Sbjct: 19 GQGTFAKVYHARNIKT--------------GESVAIKVIDKQKVAKVGLIDQIKREISVM 64
Query: 652 KDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAYIV 711
+ +H ++V FL + ++ ++ MEY++GG L D + + L E
Sbjct: 65 RLVRHPHVV-FLHEVMASKTKIYFAMEYVKGGELFDKVS--------KGKLKENIARKYF 115
Query: 712 RETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRA--TMVGTP 769
++ + + H + + HRD+K +N+LLD G +KI+DFG A K+ T GTP
Sbjct: 116 QQLIGAIDYCHSRGVYHRDLKPENLLLDENGDLKISDFGLSALRESKQQDGLLHTTCGTP 175
Query: 770 YWMAPEVVKQREYD-EKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTPKLKHP 828
++APEV+ ++ YD K DVWS G++ +L P+ +E+ L +Y T G + K P
Sbjct: 176 AYVAPEVIGKKGYDGAKADVWSCGVVLYVLLAGFLPF-HEQNLVEMYRKITKG--EFKCP 232
Query: 829 EYLSLEIKRFLSVCLCVDVKYRASTEELLHHSFF 862
+ E+K+ LS L + R E+++ +S+F
Sbjct: 233 NWFPPEVKKLLSRILDPNPNSRIKIEKIMENSWF 266
>At3g20860 [R] KOG0589 Serine/threonine protein kinase
Length = 427
Score = 108 bits (269), Expect = 5e-23
Identities = 76/274 (27%), Positives = 134/274 (48%), Gaps = 25/274 (9%)
Query: 588 FRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPR--KELIV 645
+ +VE+ G+GA GS +L +K E K +K++ L+KQ K +
Sbjct: 15 YEVVEQIGRGAFGSAFLVI------HKSERR--------KYVVKKIRLAKQTERCKLAAI 60
Query: 646 NEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEP 705
E+ ++ K IV + +++++ +D + +V Y EGG +T +I+ S + + L
Sbjct: 61 QEMSLISKLKSPYIVEYKDSWVE-KDCVCIVTSYCEGGDMTQMIKKSRGVFASEEKLCRW 119
Query: 706 QIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATM 765
+ ++ + +LH+ ++HRD+K N+ L V++ DFG AKL K ++M
Sbjct: 120 MVQLLL-----AIDYLHNNRVLHRDLKCSNIFLTKENEVRLGDFGL-AKLLGKDDLASSM 173
Query: 766 VGTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTPKL 825
VGTP +M PE++ Y K D+WSLG E+ +P + + P A + N +
Sbjct: 174 VGTPNYMCPELLADIPYGYKSDIWSLGCCMFEVAAHQPAF--KAPDMAALINKINRSSLS 231
Query: 826 KHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHH 859
P S +KR + L + ++R + ELL H
Sbjct: 232 PLPVMYSSSLKRLIKSMLRKNPEHRPTAAELLRH 265
>YPL209c [D] KOG0580 Serine/threonine protein kinase
Length = 367
Score = 107 bits (268), Expect = 6e-23
Identities = 81/284 (28%), Positives = 136/284 (47%), Gaps = 26/284 (9%)
Query: 533 NAKL-QPAREAPRVGDSNQQKTTEVSKKK---PSKPAMSNAEIMTNLKNVTFNMDPTPFF 588
N+K+ P RE N +K ++ K P + A S+ I N K F F
Sbjct: 45 NSKIPSPVREKLNRLPVNNKKFLDMESSKIPSPIRKATSSKMIHENKKLPKFKSLSLDDF 104
Query: 589 RMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKELIVNEI 648
+ +K G+G G VY R + Y L+ + K I + L KQ R+E+ +
Sbjct: 105 ELGKKLGKGKFGKVYCV-RHRSTGYICALKVME-----KEEIIKYNLQKQFRREVEIQTS 158
Query: 649 LVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIA 708
L H N+ Y E ++++MEY+ G + ++ P + +
Sbjct: 159 L-----NHPNLTKSY-GYFHDEKRVYLLMEYLVNGEMYKLLRL-------HGPFNDILAS 205
Query: 709 YIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMVGT 768
+ + L ++H K+IIHRDIK +N+L+ +K+TDFG+ + ++R T+ GT
Sbjct: 206 DYIYQIANALDYMHKKNIIHRDIKPENILIGFNNVIKLTDFGWSI-INPPENRRKTVCGT 264
Query: 769 PYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLK 812
+++PE+V+ REYD +D W+LG++ E+L PP+ EE +K
Sbjct: 265 IDYLSPEMVESREYDHTIDAWALGVLAFELLTGAPPF--EEEMK 306
>YOR231w [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 508
Score = 107 bits (268), Expect = 6e-23
Identities = 85/279 (30%), Positives = 136/279 (48%), Gaps = 35/279 (12%)
Query: 595 GQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMI--LSKQPR-KELIVNEILVM 651
G+GA GSV K + G+K+ ++I L+ P ++ I E+
Sbjct: 228 GEGAGGSVSKC---------------KLKNGSKIFALKVINTLNTDPEYQKQIFRELQFN 272
Query: 652 KDSKHNNIVNFLEAYLKTEDD-LWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAYI 710
+ + IV + + E+ +++ MEYM G SL I +N ++E + I
Sbjct: 273 RSFQSEYIVRYYGMFTDDENSSIYIAMEYMGGRSLDAIYKNLLERGGR---ISEKVLGKI 329
Query: 711 VRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMVGTPY 770
+GL +LH+K +IHRDIK N+LL+ G+VK+ DFG + + S T GT +
Sbjct: 330 AEAVLRGLSYLHEKKVIHRDIKPQNILLNENGQVKLCDFGVSGEAVN--SLATTFTGTSF 387
Query: 771 WMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEE------PLKALYLIATNGTPK 824
+MAPE ++ + Y DVWSLG+ +E+ + P +E+ P + L I T TP+
Sbjct: 388 YMAPERIQGQPYSVTSDVWSLGLTILEVANGKFPCSSEKMAANIAPFELLMWILT-FTPE 446
Query: 825 LK-HPE---YLSLEIKRFLSVCLCVDVKYRASTEELLHH 859
LK PE S K F+ CL D + R S ++++H
Sbjct: 447 LKDEPESNIIWSPSFKSFIDYCLKKDSRERPSPRQMINH 485
>CE02377 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 1211
Score = 107 bits (268), Expect = 6e-23
Identities = 71/288 (24%), Positives = 134/288 (45%), Gaps = 25/288 (8%)
Query: 575 LKNVTFNMDPTPFFRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMI 634
++N+ N+ +++ + G G G VY + + G + A K +
Sbjct: 32 IENIRANVKFDTLYQVTKLLGDGKFGKVYCVI--------------EKETGKEFAAKFIK 77
Query: 635 LSKQPRKELIVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPT 694
+ K+ + + E+ ++ +H I +A+ T +D+ ++ME + GG L D +
Sbjct: 78 IRKEADRAEVEREVSILTQLRHPRIAQIYDAFYTTTNDVVLIMEIVRGGELFDRVAEE-- 135
Query: 695 GSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLD--TRGRVKITDFGFC 752
L+E + I+ + C+ + ++H ++I+H D+K +N++ T R+K+ DFG
Sbjct: 136 ----SYVLSELAVVMIICQLCEAIDYIHKQNILHLDVKPENIMCVSLTGNRIKLIDFGL- 190
Query: 753 AKLTDKRSKRATMVGTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLK 812
A+ D + M GTP + APEV+K + D D+WS+G++T +L P+L + L
Sbjct: 191 ARHYDGTQELKYMAGTPEFAAPEVIKFEKLDYHTDMWSIGVITYILLSGYSPFLGDN-LG 249
Query: 813 ALYLIATNGTPKLKHP-EYLSLEIKRFLSVCLCVDVKYRASTEELLHH 859
Y G + + ++ E K F++ L D R E L H
Sbjct: 250 ETYCNVEKGVWEFTEEFDTVTEEAKDFVTKLLVYDQSKRMLPHECLQH 297
>At3g29160 [T] KOG0583 Serine/threonine protein kinase
Length = 512
Score = 107 bits (268), Expect = 6e-23
Identities = 83/283 (29%), Positives = 141/283 (49%), Gaps = 34/283 (12%)
Query: 586 PFFRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRK---- 641
P +++ + G G+ G V +AE + G+KVAIK IL+++ K
Sbjct: 18 PNYKLGKTLGIGSFGKVKIAEHVVT--------------GHKVAIK--ILNRRKIKNMEM 61
Query: 642 -ELIVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQS 700
E + EI +++ H +I+ E ++T D++VVMEY++ G L D I +
Sbjct: 62 EEKVRREIKILRLFMHPHIIRQYEV-IETTSDIYVVMEYVKSGELFDYIVE-------KG 113
Query: 701 PLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRS 760
L E + ++ G+++ H ++HRD+K +N+LLD+R +KI DFG + D
Sbjct: 114 RLQEDEARNFFQQIISGVEYCHRNMVVHRDLKPENLLLDSRCNIKIADFGLSNVMRDGHF 173
Query: 761 KRATMVGTPYWMAPEVVKQREY-DEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIAT 819
+ T G+P + APEV+ + Y +VDVWS G++ +L P+ ++E + L+
Sbjct: 174 LK-TSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYALLCGTLPF-DDENIPNLFKKIK 231
Query: 820 NGTPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSFF 862
G L P +LS E + + L VD R + E+ H +F
Sbjct: 232 GGIYTL--PSHLSSEARDLIPRMLIVDPVKRITIPEIRQHRWF 272
>At2g37840 [OUT] KOG0595 Serine/threonine-protein kinase involved in autophagy
Length = 257
Score = 107 bits (268), Expect = 6e-23
Identities = 60/202 (29%), Positives = 111/202 (54%), Gaps = 14/202 (6%)
Query: 618 EAEKNQLGNKVAIKQMILSKQPRK--ELIVNEILVMKDSKHNNIVNFLEAYLKTEDDLWV 675
EA G +VAIK++ + + +K E +++EI +++ H NI+ ++ +K+ + +
Sbjct: 28 EARHRVDGTEVAIKEIAMDRLNKKLQESLMSEIFILRRINHPNIIRLIDM-IKSPGKVHL 86
Query: 676 VMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDN 735
V+EY +GG L+ ++ + E + +++ GL+ L D +IIHRD+K N
Sbjct: 87 VLEYCKGGDLSVYVQR-------HGIVPEATAKHFMQQLAAGLQVLRDNNIIHRDLKPQN 139
Query: 736 VLLDTRGR---VKITDFGFCAKLTDKRSKRATMVGTPYWMAPEVVKQREYDEKVDVWSLG 792
+LL T +KI DFGF L R T+ G+P +MAPE+++ ++YD K D+WS+G
Sbjct: 140 LLLSTNENDADLKIADFGFARSL-QPRGLAETLCGSPLYMAPEIMQLQKYDAKADLWSVG 198
Query: 793 IMTIEMLESEPPYLNEEPLKAL 814
+ +++ P+ ++ L
Sbjct: 199 AILFQLVTGRTPFTGNSQIQLL 220
>At2g25090 [T] KOG0583 Serine/threonine protein kinase
Length = 469
Score = 107 bits (268), Expect = 6e-23
Identities = 74/240 (30%), Positives = 117/240 (47%), Gaps = 21/240 (8%)
Query: 627 KVAIKQMILSKQPRKELIVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLT 686
KV K + ++ E I EI VM+ +H N+V E + T+ ++ VMEY+ GG L
Sbjct: 44 KVIKKDHVFKRRGMMEQIEREIAVMRLLRHPNVVELREV-MATKKKIFFVMEYVNGGELF 102
Query: 687 DIIENSPTGSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKI 746
++I+ L E ++ + F H + + HRDIK +N+LLD G +K+
Sbjct: 103 EMIDRD-------GKLPEDLARKYFQQLISAVDFCHSRGVFHRDIKPENLLLDGEGDLKV 155
Query: 747 TDFGFCAKLTDK--RSKRA-------TMVGTPYWMAPEVVKQREYD-EKVDVWSLGIMTI 796
TDFG A + + +R T GTP ++APEV++ + YD D+WS GI+
Sbjct: 156 TDFGLSALMMPEGLGGRRGSSDDLLHTRCGTPAYVAPEVLRNKGYDGAMADIWSCGIVLY 215
Query: 797 EMLESEPPYLNEEPLKALYLIATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEEL 856
+L P+++E + L + + P + SLE K LS L D + R S E+
Sbjct: 216 ALLAGFLPFIDE---NVMTLYTKIFKAECEFPPWFSLESKELLSRLLVPDPEQRISMSEI 272
>At1g29230 [T] KOG0583 Serine/threonine protein kinase
Length = 520
Score = 107 bits (268), Expect = 6e-23
Identities = 81/325 (24%), Positives = 148/325 (44%), Gaps = 44/325 (13%)
Query: 544 RVGDSNQQKTTEVSKKKPSKPAMSNAEIMTNLKNVTFNMDPTPFFRMVEKAGQGASGSVY 603
R+G + K +S + P P I+ + + + G G VY
Sbjct: 42 RIGIMDTDKDGNISPQSPRSPRSPRNNILMGK------------YELGKLLGHGTFAKVY 89
Query: 604 LAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKELIVN---EILVMKDSKHNNIV 660
LA+ ++ G+KVAIK + K + L+ + EI +++ +H IV
Sbjct: 90 LAQNIKS--------------GDKVAIKVIDKEKIMKSGLVAHIKREISILRRVRHPYIV 135
Query: 661 NFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAYIVRETCQGLKF 720
+ E + T+ ++ VMEY+ GG L + + + L E ++ + F
Sbjct: 136 HLFEV-MATKSKIYFVMEYVGGGELFNTV--------AKGRLPEETARRYFQQLISSVSF 186
Query: 721 LHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRA--TMVGTPYWMAPEVVK 778
H + + HRD+K +N+LLD +G +K++DFG A R T GTP ++APEV+
Sbjct: 187 CHGRGVYHRDLKPENLLLDNKGNLKVSDFGLSAVAEQLRQDGLCHTFCGTPAYIAPEVLT 246
Query: 779 QREYD-EKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTPKLKHPEYLSLEIKR 837
++ YD K DVWS G++ ++ P+ ++ + +Y G + + P + S ++ R
Sbjct: 247 RKGYDAAKADVWSCGVILFVLMAGHIPFYDKN-IMVMYKKIYKG--EFRCPRWFSSDLVR 303
Query: 838 FLSVCLCVDVKYRASTEELLHHSFF 862
L+ L + R + E++ + +F
Sbjct: 304 LLTRLLDTNPDTRITIPEIMKNRWF 328
>7299322 [R] KOG0611 Predicted serine/threonine protein kinase
Length = 434
Score = 107 bits (268), Expect = 6e-23
Identities = 79/280 (28%), Positives = 130/280 (46%), Gaps = 31/280 (11%)
Query: 588 FRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKELIVN- 646
F +++K GQG G V L + G +VAIK + K + +V
Sbjct: 82 FDIIKKLGQGTYGKVQLGIN--------------KETGQEVAIKTIKKCKIEAEADLVRI 127
Query: 647 --EILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTE 704
E+ +M H NI++ E + + + + +VME+ GG L D + S + LTE
Sbjct: 128 RREVQIMSSVHHPNIIHIYEVF-ENREKMVLVMEFAAGGELYDYL-------SERKVLTE 179
Query: 705 PQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRAT 764
+ I R+ + + H I HRD+K +N+LLD +G KI DFG D+R T
Sbjct: 180 EEARRIFRQVATAVYYCHKHKICHRDLKLENILLDEKGNAKIADFGLSNVFDDQR-LLGT 238
Query: 765 MVGTPYWMAPEVVKQREYD-EKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTP 823
G+P + +PE+V+ Y +VD WSLG++ ++ P+ + + I+
Sbjct: 239 FCGSPLYASPEIVEGTPYQGPEVDCWSLGVLLYTLVYGSMPFDGSNFKRLVKQISQGDYY 298
Query: 824 KLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSFFN 863
+ + P S I+ L+VC + RAS E++ H + N
Sbjct: 299 EPRKPSRASTLIRDMLTVC----PRKRASIEQICSHWWVN 334
>7290150 [T] KOG0583 Serine/threonine protein kinase
Length = 582
Score = 107 bits (268), Expect = 6e-23
Identities = 78/242 (32%), Positives = 124/242 (51%), Gaps = 20/242 (8%)
Query: 627 KVAIKQMILSKQPRKELIV-----NEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYME 681
KVA+K IL++Q K L V EI +K +H +I+ + + T D++++MEY+
Sbjct: 53 KVAVK--ILNRQKIKSLDVVGKIRREIQNLKLFRHPHIIKLYQV-ISTPSDIFMIMEYVS 109
Query: 682 GGSLTDIIENSPTGSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTR 741
GG L D I L E Q ++ G+ + H I+HRD+K +N+LLD
Sbjct: 110 GGELFDYIVK-------HGKLQEHQARRFFQQIISGVDYCHRHMIVHRDLKPENLLLDHN 162
Query: 742 GRVKITDFGFCAKLTDKRSKRATMVGTPYWMAPEVVKQREY-DEKVDVWSLGIMTIEMLE 800
VKI DFG + D R T G+P + APEV+ + Y +VD+WS G++ +L
Sbjct: 163 MHVKIADFGLSNMMLDGEFLR-TSCGSPNYAAPEVISGKLYAGPEVDIWSCGVILYALLC 221
Query: 801 SEPPYLNEEPLKALYLIATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHS 860
P+ ++E + L+ +G + PEYL+ ++ + L VD RA+ EE+ H
Sbjct: 222 GTLPF-DDEHVPTLFRKIKSGIFPI--PEYLNKQVVNLVCQMLQVDPLKRANIEEIKKHE 278
Query: 861 FF 862
+F
Sbjct: 279 WF 280
>YPL140c [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 506
Score = 107 bits (267), Expect = 8e-23
Identities = 83/276 (30%), Positives = 131/276 (47%), Gaps = 29/276 (10%)
Query: 595 GQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKELIVNEILVMKDS 654
G+GA GSV K L+ K K I M + +K+ I E+ K
Sbjct: 221 GEGAGGSVA----------KCRLKNGKKVFALKT-INTMNTDPEYQKQ-IFRELQFNKSF 268
Query: 655 KHNNIVNFLEAYLKTEDD-LWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAYIVRE 713
K + IV + + + +++ MEYM G SL +N ++E I I
Sbjct: 269 KSDYIVQYYGMFTDEQSSSIYIAMEYMGGKSLEATYKNLLKRGGR---ISERVIGKIAES 325
Query: 714 TCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMVGTPYWMA 773
+GL +LH++ +IHRDIK N+LL+ +G +K+ DFG + + S T GT ++MA
Sbjct: 326 VLRGLSYLHERKVIHRDIKPQNILLNEKGEIKLCDFGVSGEAVN--SLAMTFTGTSFYMA 383
Query: 774 PEVVKQREYDEKVDVWSLGIMTIEM------LESEPPYLNEEPLKALYLIATNGTPKLKH 827
PE ++ + Y DVWSLG+ +E+ ES+ N P++ L +I T +P+LK
Sbjct: 384 PERIQGQPYSVTCDVWSLGLTLLEVAGGRFPFESDKITQNVAPIELLTMILT-FSPQLKD 442
Query: 828 PEYLSLE----IKRFLSVCLCVDVKYRASTEELLHH 859
L + + F+ CL D + R S ++L H
Sbjct: 443 EPELDISWSKTFRSFIDYCLKKDARERPSPRQMLKH 478
>Hs4505569 [R] KOG0593 Predicted protein kinase KKIAMRE
Length = 493
Score = 107 bits (267), Expect = 8e-23
Identities = 82/279 (29%), Positives = 127/279 (45%), Gaps = 39/279 (13%)
Query: 617 LEAEKNQLGNKVAIKQMILSKQPR--KELIVNEILVMKDSKHNNIVNFLEAYLKTEDDLW 674
++ G VAIK+ + S + K++ + EI ++K +H N+VN LE K + +
Sbjct: 19 MKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHENLVNLLEV-CKKKKRWY 77
Query: 675 VVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSD 734
+V E+++ L D+ E P G Q + + + I+ G+ F H +IIHRDIK +
Sbjct: 78 LVFEFVDHTILDDL-ELFPNGLDYQ--VVQKYLFQIIN----GIGFCHSHNIIHRDIKPE 130
Query: 735 NVLLDTRGRVKITDFGFCAKLTDKRSKRATMVGTPYWMAPE-VVKQREYDEKVDVWSLGI 793
N+L+ G VK+ DFGF L V T ++ APE +V +Y + VDVW++G
Sbjct: 131 NILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYRAPELLVGDVKYGKAVDVWAIGC 190
Query: 794 MTIEMLESEPPYLNEEPLKALY---------------------LIATNGTPKLKHPEYLS 832
+ EM EP + + + LY + A P++K E L
Sbjct: 191 LVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPVFAGVRLPEIKEREPLE 250
Query: 833 LEIKRFLSV-------CLCVDVKYRASTEELLHHSFFNM 864
+ V CL +D R ELLHH FF M
Sbjct: 251 RRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQM 289
>Hs22068916 [T] KOG0696 Serine/threonine protein kinase
Length = 673
Score = 107 bits (267), Expect = 8e-23
Identities = 84/274 (30%), Positives = 127/274 (45%), Gaps = 27/274 (9%)
Query: 543 PRVGDSNQQKTTEVSKKKPSKPAMSNAEIMTNLKNVTFN------MDPTPF-FRMVEKAG 595
P ++N++ + + K S+ E TN + N M T F F MV G
Sbjct: 292 PEGSEANEELRQKFERAKISQGTKVPEEKTTNTVSKFDNNGNRDRMKLTDFNFLMV--LG 349
Query: 596 QGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKELIVNEILVMKDSK 655
+G+ G V L+ER DEL A K +K+ ++ + E + E V+
Sbjct: 350 KGSFGKVMLSERKGT----DELYAVK-------ILKKDVVIQDDDVECTMVEKRVLALPG 398
Query: 656 HNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAYIVRETC 715
+ L + +T D L+ VMEY+ GG L I+ EP + E
Sbjct: 399 KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQV-------GRFKEPHAVFYAAEIA 451
Query: 716 QGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMVGTPYWMAPE 775
GL FL K II+RD+K DNV+LD+ G +KI DFG C + T GTP ++APE
Sbjct: 452 IGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPE 511
Query: 776 VVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEE 809
++ + Y + VD W+ G++ EML + P+ E+
Sbjct: 512 IIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGED 545
>Hs21735544 [T] KOG0983 Mitogen-activated protein kinase (MAPK) kinase
MKK7/JNKK2
Length = 419
Score = 107 bits (267), Expect = 8e-23
Identities = 75/246 (30%), Positives = 126/246 (50%), Gaps = 18/246 (7%)
Query: 625 GNKVAIKQMILS--KQPRKELIVNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEG 682
G+ +A+KQM S K+ K ++++ +V+K IV ++ T D+++ ME M
Sbjct: 143 GHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFI-TNTDVFIAMELM-- 199
Query: 683 GSLTDIIENSPTGSSGQSPLTEPQIAYIVRETCQGLKFLHDKH-IIHRDIKSDNVLLDTR 741
G+ + ++ G P+ E + + + L +L +KH +IHRD+K N+LLD R
Sbjct: 200 GTCAEKLKKRMQG-----PIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDER 254
Query: 742 GRVKITDFGFCAKLTDKRSKRATMVGTPYWMAPEVV-----KQREYDEKVDVWSLGIMTI 796
G++K+ DFG +L D ++K + G +MAPE + + +YD + DVWSLGI +
Sbjct: 255 GQIKLCDFGISGRLVDSKAKTRS-AGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLV 313
Query: 797 EMLESEPPYLN-EEPLKALYLIATNGTPKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEE 855
E+ + PY N + + L + P L S + + F+ CL D + R +
Sbjct: 314 ELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNK 373
Query: 856 LLHHSF 861
LL HSF
Sbjct: 374 LLEHSF 379
>Hs20127450 [T] KOG0696 Serine/threonine protein kinase
Length = 673
Score = 107 bits (267), Expect = 8e-23
Identities = 84/274 (30%), Positives = 127/274 (45%), Gaps = 27/274 (9%)
Query: 543 PRVGDSNQQKTTEVSKKKPSKPAMSNAEIMTNLKNVTFN------MDPTPF-FRMVEKAG 595
P ++N++ + + K S+ E TN + N M T F F MV G
Sbjct: 292 PEGSEANEELRQKFERAKISQGTKVPEEKTTNTVSKFDNNGNRDRMKLTDFNFLMV--LG 349
Query: 596 QGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKELIVNEILVMKDSK 655
+G+ G V L+ER DEL A K +K+ ++ + E + E V+
Sbjct: 350 KGSFGKVMLSERKGT----DELYAVK-------ILKKDVVIQDDDVECTMVEKRVLALPG 398
Query: 656 HNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAYIVRETC 715
+ L + +T D L+ VMEY+ GG L I+ EP + E
Sbjct: 399 KPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQV-------GRFKEPHAVFYAAEIA 451
Query: 716 QGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMVGTPYWMAPE 775
GL FL K II+RD+K DNV+LD+ G +KI DFG C + T GTP ++APE
Sbjct: 452 IGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPE 511
Query: 776 VVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEE 809
++ + Y + VD W+ G++ EML + P+ E+
Sbjct: 512 IIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGED 545
>ECU01g1320 [T] KOG0612 Rho-associated coiled-coil containing protein kinase
Length = 865
Score = 107 bits (267), Expect = 8e-23
Identities = 88/324 (27%), Positives = 150/324 (46%), Gaps = 40/324 (12%)
Query: 545 VGDSNQQKTTEVSKKKPSKPAMSNAEIMTNLKNVTFNMDPTPFFRMVEKAGQGASGSVYL 604
+GD + E+S+K+ + P + LK V + +V+ +G G V+L
Sbjct: 9 IGDCLEAVYHEISEKRINVP-------VDRLKEVVEAKTKPSDYEIVKNVAKGGYGEVFL 61
Query: 605 AERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKELIVNEILVMKDSKHNNIVNFLE 664
R EK +V+ K+++L KQP L + E M D + +
Sbjct: 62 VRR------------EKIYAMKRVS-KELVL-KQPHTALFMAEKEAMVDCIGSEWLVCAH 107
Query: 665 AYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAYIVRETCQGLKFLHDK 724
++ E+ L+ +M+++ GG ++ S + L E + + E L LH
Sbjct: 108 MTMQDEEYLYYLMDFIPGGDFMGLL-------SKEDVLEEDWVRFYAAEIVAALDELHKL 160
Query: 725 HIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMVGTPYWMAPEVV----KQR 780
IHRD+K DNVL+ G VK+ DFG C K+ D +++ + VGTP +++P+V+ ++
Sbjct: 161 GWIHRDLKPDNVLIGIDGHVKLADFGSCIKMKDGKARSSITVGTPDYVSPDVLCSVNEEC 220
Query: 781 EYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLI--ATNGTPKLKHPEYLSLEIKRF 838
EY E VD W+LG++ EM+ P+ ++ ++ I G P PE SL I+
Sbjct: 221 EYGEDVDFWTLGVIIYEMIYGTTPFYSDTLMETYRRITRVEFGFPFKVSPELTSL-IEGL 279
Query: 839 LSVCLCVDVKYRASTEELLHHSFF 862
++ R EE+ H+FF
Sbjct: 280 IAA-----KDRRMRIEEIKSHAFF 298
>7300106 [T] KOG0690 Serine/threonine protein kinase
Length = 530
Score = 107 bits (267), Expect = 8e-23
Identities = 79/280 (28%), Positives = 127/280 (45%), Gaps = 27/280 (9%)
Query: 588 FRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKELIVNE 647
F ++ G+G G V L +A K+ K++I+ K + E
Sbjct: 185 FEFLKVLGKGTFGKVILCRE----------KATAKLYAIKILKKEVIIQKDEVAHTLT-E 233
Query: 648 ILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQI 707
V+K + H +++ L+ +T D L VM+Y+ GG L + S + TE +
Sbjct: 234 SRVLKSTNHPFLIS-LKYSFQTNDRLCFVMQYVNGGELFWHL-------SHERIFTEDRT 285
Query: 708 AYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMVG 767
+ E L +LH + II+RD+K +N+LLD G +K+ DFG C + T G
Sbjct: 286 RFYGAEIISALGYLHSQGIIYRDLKLENLLLDKDGHIKVADFGLCKEDITYGRTTKTFCG 345
Query: 768 TPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTPKLKH 827
TP ++APEV+ +Y + VD W G++ EM+ P+ N + LI ++K
Sbjct: 346 TPEYLAPEVLDDNDYGQAVDWWGTGVVMYEMICGRLPFYNRDHDVLFTLILVE---EVKF 402
Query: 828 PEYLSLEIKRFLSVCLCVDVKYRA-----STEELLHHSFF 862
P ++ E K L+ L D K R +E+ H FF
Sbjct: 403 PRNITDEAKNLLAGLLAKDPKKRLGGGKDDVKEIQAHPFF 442
>7299437 [R] KOG0586 Serine/threonine protein kinase
Length = 604
Score = 107 bits (267), Expect = 8e-23
Identities = 80/284 (28%), Positives = 144/284 (50%), Gaps = 31/284 (10%)
Query: 588 FRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIK---QMILSKQPRKELI 644
+++++ G+G V LA + LP G +VAIK + L+ R++L
Sbjct: 63 YKIIKTLGKGNFAKVKLA--IHLPT------------GREVAIKLIDKTALNTIARQKLY 108
Query: 645 VNEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTE 704
E+ +MK H NIV L+ +++E L++VMEY+ GG L + + + + E
Sbjct: 109 -REVNIMKKLNHPNIVRLLQV-IESERTLYLVMEYVSGGELFNYLVKN-------GRMRE 159
Query: 705 PQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRAT 764
+ R+ +++ H K I+HRD+K++N+LLD + ++KI DFGF + ++ T
Sbjct: 160 RDARVLFRQLVSAIEYCHSKSIVHRDLKAENLLLDQQMKLKIADFGFSTTF-EPKAPLET 218
Query: 765 MVGTPYWMAPEVVKQREYD-EKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTP 823
G+P + APE+ + ++Y +VD WSLG++ ++ P+ + LK L G
Sbjct: 219 FCGSPPYAAPELFRGKKYSGPEVDSWSLGVVLYTLVSGSLPF-DGTNLKELRDRVLRG-- 275
Query: 824 KLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSFFNMSCE 867
K + P Y+S+E + + L ++ R S ++ + NM E
Sbjct: 276 KYRVPYYVSIECESLIRKFLVLNPTQRTSLSAVMADRWINMGYE 319
>Hs22050308_2 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 291
Score = 107 bits (267), Expect = 8e-23
Identities = 78/272 (28%), Positives = 133/272 (48%), Gaps = 23/272 (8%)
Query: 606 ERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKE------LIVNEILVMKDSKHNNI 659
+++ L + +A+ G +A+KQ+ + E + EI +M H NI
Sbjct: 24 QQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNI 83
Query: 660 VNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAYIVRETCQGLK 719
+ L A + + + + +E+M GGS+ ++ S E + + +GL
Sbjct: 84 IRMLGATCE-KSNYNLFIEWMAGGSVAHLL-------SKYGAFKESVVINYTEQLLRGLS 135
Query: 720 FLHDKHIIHRDIKSDNVLLDTRG-RVKITDFGFCAKLTDKRSK----RATMVGTPYWMAP 774
+LH+ IIHRD+K N+L+D+ G R++I DFG A+L K + + ++GT +MAP
Sbjct: 136 YLHENQIIHRDVKGANLLIDSTGQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAP 195
Query: 775 EVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYL----IATNGTPKLKHPEY 830
EV++ ++Y DVWS+G IEM ++PP+ E+ L L I + T P +
Sbjct: 196 EVLRGQQYGRSCDVWSVGCAIIEMACAKPPWNAEKHSNHLALIFKVIIASATTAPSIPSH 255
Query: 831 LSLEIKRFLSVCLCVDVKYRASTEELLHHSFF 862
LS ++ CL + + R + ELL H F
Sbjct: 256 LSPGLRDVALRCLELQPQDRPPSRELLKHPVF 287
>SPAC890.03 [T] KOG0583 Serine/threonine protein kinase
Length = 672
Score = 107 bits (266), Expect = 1e-22
Identities = 81/279 (29%), Positives = 129/279 (46%), Gaps = 34/279 (12%)
Query: 588 FRMVEKAGQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKELIV-- 645
+R+ G+G+ G VYLA L + +++L RK+ I+
Sbjct: 31 YRIESVVGEGSFGKVYLAAHL-------------------LTNTKVVLKSSCRKQAIILA 71
Query: 646 NEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEP 705
EI + H NI E TED +++ MEY G L D + + L E
Sbjct: 72 REIHHHRRLLHPNITRLYEVVC-TEDRIYLAMEYCPNGELYDWVAR-------EKRLDEK 123
Query: 706 QIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKL-TDKRSKRAT 764
I+ + C +++LH + +HRD+K +N+ LD VK+ DFGF +R+ T
Sbjct: 124 TTCRIMWQLCCAIQYLHRQGCVHRDLKLENIFLDKAYNVKLGDFGFSRDSDCSRRTFMNT 183
Query: 765 MVGTPYWMAPEVVKQREY-DEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTP 823
GT + APE+V+ +Y E VD+WSLGI+ +L P+ +E+ + N P
Sbjct: 184 RCGTVAYCAPELVQGHKYIGECVDIWSLGIIMYALLIGRLPF-DEDDVSLTEQKIINECP 242
Query: 824 KLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSFF 862
++PE LS L LC D + R S ++++ H +F
Sbjct: 243 --QYPETLSKNSSSLLKSLLCKDYRLRPSIDQIISHPYF 279
>Hs5453970 [T] KOG0694 Serine/threonine protein kinase
Length = 676
Score = 107 bits (266), Expect = 1e-22
Identities = 78/245 (31%), Positives = 124/245 (49%), Gaps = 21/245 (8%)
Query: 595 GQGASGSVYLAERLQLPPYKDELEAEKNQLGNKVAIKQMILSKQPRKELIVNEILVMKDS 654
G+G+ G V L E + E A K A+K+ ++ E + E V+ +
Sbjct: 356 GKGSFGKVLLGELKG----RGEYSAIK-------ALKKDVVLIDDDVECTMVEKRVLTLA 404
Query: 655 KHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEPQIAYIVRET 714
N + L +T+D L+ VME++ GG L I++ G+ L + + E
Sbjct: 405 AENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDK-----GRFELY--RATFYAAEI 457
Query: 715 CQGLKFLHDKHIIHRDIKSDNVLLDTRGRVKITDFGFCAKLTDKRSKRATMVGTPYWMAP 774
GL+FLH K II+RD+K DNVLLD G +KI DFG C + S+ +T GTP ++AP
Sbjct: 458 MCGLQFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAP 517
Query: 775 EVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGTPKLKHPEYLSLE 834
E+++ +Y VD WS G++ EML + P+ ++ + I + TP +P +++ E
Sbjct: 518 EILQGLKYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVD-TP--HYPRWITKE 574
Query: 835 IKRFL 839
K L
Sbjct: 575 SKDIL 579
>ECU05g0630 [R] KOG0584 Serine/threonine protein kinase
Length = 694
Score = 107 bits (266), Expect = 1e-22
Identities = 93/289 (32%), Positives = 135/289 (46%), Gaps = 24/289 (8%)
Query: 592 EKAGQGASGSVY--LAERLQLPPYKDELEAEKNQLGNKVAIKQMILSK--QPRKE--LIV 645
EK G G GS Y L L +K +A + G +VA ++ +S+ Q KE L
Sbjct: 42 EKKG-GVDGSRYKKLQTILGEGTFKKVYKAIDQEEGKEVAWNEIKISEKGQDSKERGLFA 100
Query: 646 NEILVMKDSKHNNIVNFLEAYLKTEDDLWVVMEYMEGGSLTDIIENSPTGSSGQSPLTEP 705
NEI ++K H N++ L+ Y T D + E M GG+L + I L
Sbjct: 101 NEIALLKSISHPNVLRILD-YWFTPDSFIFITELMSGGTLREYIAEI-------GDLNVK 152
Query: 706 QIAYIVRETCQGLKFLH--DKHIIHRDIKSDNVLLDTR-GRVKITDFGFCAKLTDKRSKR 762
I R +GL +LH D IIHRDIK +N+ ++ G VKI D G ++R KR
Sbjct: 153 LIKKWGRHILEGLVYLHSQDPPIIHRDIKCENIFVNAALGEVKIGDLGVAK---ERRMKR 209
Query: 763 ATMVGTPYWMAPEVVKQREYDEKVDVWSLGIMTIEMLESEPPYLNEEPLKALYLIATNGT 822
T+VGTP +MA E+ + Y EK+DV++ G+ IEM PY +Y G
Sbjct: 210 YTVVGTPQFMAREMFEGEGYCEKIDVYAFGMCLIEMATGAYPYKECTTAAEVYKAIIQGV 269
Query: 823 PKLKHPEYLSLEIKRFLSVCLCVDVKYRASTEELLHHSFF--NMSCESQ 869
P + + ++ + CL V K R + + L H FF N +C +
Sbjct: 270 PPVALSSIKDVCLRNLIMNCL-VSEKDRLRSVDCLKHHFFDSNNTCNGE 317
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.314 0.130 0.378
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 48,625,999
Number of Sequences: 60738
Number of extensions: 2018333
Number of successful extensions: 10118
Number of sequences better than 1.0e-05: 1764
Number of HSP's better than 0.0 without gapping: 386
Number of HSP's successfully gapped in prelim test: 1378
Number of HSP's that attempted gapping in prelim test: 6514
Number of HSP's gapped (non-prelim): 2105
length of query: 879
length of database: 30,389,216
effective HSP length: 115
effective length of query: 764
effective length of database: 23,404,346
effective search space: 17880920344
effective search space used: 17880920344
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)