ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactI1973 good U KOG2058 Intracellular trafficking, secretion, and vesicular transport Ypt/Rab GTPase activating protein
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactI1973 673198 675054 619
(619 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YNL293w [U] KOG2058 Ypt/Rab GTPase activating protein 565 e-161
YOL112w [U] KOG2058 Ypt/Rab GTPase activating protein 417 e-116
SPCC4G3.09c [U] KOG2058 Ypt/Rab GTPase activating protein 312 1e-84
Hs22042713 [R] KOG4347 GTPase-activating protein VRP 147 6e-35
Hs5902154 [R] KOG4347 GTPase-activating protein VRP 139 2e-32
At5g15930 [R] KOG1102 Rab6 GTPase activator GAPCenA and related ... 132 1e-30
Hs21361485 [U] KOG2221 PDZ-domain interacting protein EPI64 cont... 131 3e-30
Hs13994322 [U] KOG2221 PDZ-domain interacting protein EPI64 cont... 131 3e-30
7296423 [R] KOG4347 GTPase-activating protein VRP 131 3e-30
Hs11034851 [TR] KOG2222 Uncharacterized conserved protein contai... 129 1e-29
Hs17485595 [R] KOG4347 GTPase-activating protein VRP 127 4e-29
CE19171 [R] KOG4347 GTPase-activating protein VRP 127 5e-29
CE18397 [R] KOG4347 GTPase-activating protein VRP 127 5e-29
7300111 [U] KOG2058 Ypt/Rab GTPase activating protein 124 4e-28
Hs13376023 [U] KOG2058 Ypt/Rab GTPase activating protein 122 1e-27
7299972 [TR] KOG2222 Uncharacterized conserved protein contains ... 121 4e-27
At3g02460 [R] KOG1102 Rab6 GTPase activator GAPCenA and related ... 120 6e-27
YGR100w [R] KOG4347 GTPase-activating protein VRP 119 1e-26
7299471 [U] KOG2221 PDZ-domain interacting protein EPI64 contain... 118 3e-26
Hs7661864 [R] KOG1102 Rab6 GTPase activator GAPCenA and related ... 117 7e-26
Hs22056446 [U] KOG2058 Ypt/Rab GTPase activating protein 116 9e-26
Hs8922167 [U] KOG2058 Ypt/Rab GTPase activating protein 116 1e-25
At3g07890 [U] KOG2058 Ypt/Rab GTPase activating protein 114 3e-25
CE08508 [U] KOG2058 Ypt/Rab GTPase activating protein 114 4e-25
7303241 [R] KOG1102 Rab6 GTPase activator GAPCenA and related TB... 114 4e-25
At3g55020 [U] KOG2058 Ypt/Rab GTPase activating protein 113 7e-25
CE29155 [U] KOG2058 Ypt/Rab GTPase activating protein 113 1e-24
CE28983 [R] KOG1102 Rab6 GTPase activator GAPCenA and related TB... 107 5e-23
CE17203 [U] KOG2221 PDZ-domain interacting protein EPI64 contain... 104 3e-22
Hs18590199 [R] KOG4436 Predicted GTPase activator NB4S/EVI5 (con... 102 2e-21
SPCC1259.11c [R] KOG4347 GTPase-activating protein VRP 100 7e-21
SPBC215.01 [R] KOG4347 GTPase-activating protein VRP 100 9e-21
Hs19923325_1 [R] KOG4436 Predicted GTPase activator NB4S/EVI5 (c... 99 1e-20
CE10236 [TR] KOG2222 Uncharacterized conserved protein contains ... 99 2e-20
Hs12232373 [R] KOG1102 Rab6 GTPase activator GAPCenA and related... 97 6e-20
CE27154 [R] KOG1102 Rab6 GTPase activator GAPCenA and related TB... 97 9e-20
CE27153 [R] KOG1102 Rab6 GTPase activator GAPCenA and related TB... 94 6e-19
Hs18580214 [U] KOG2058 Ypt/Rab GTPase activating protein 92 2e-18
CE07531 [R] KOG4436 Predicted GTPase activator NB4S/EVI5 (contai... 91 4e-18
Hs20532509 [R] KOG4436 Predicted GTPase activator NB4S/EVI5 (con... 90 9e-18
7292646 [R] KOG4436 Predicted GTPase activator NB4S/EVI5 (contai... 90 9e-18
SPAC4G8.04 [U] KOG2058 Ypt/Rab GTPase activating protein 89 2e-17
7295111 [R] KOG1102 Rab6 GTPase activator GAPCenA and related TB... 89 2e-17
7296688 [R] KOG4436 Predicted GTPase activator NB4S/EVI5 (contai... 87 6e-17
YPL249c [R] KOG1102 Rab6 GTPase activator GAPCenA and related TB... 85 3e-16
Hs7662198 [R] KOG4436 Predicted GTPase activator NB4S/EVI5 (cont... 82 2e-15
Hs22058425 [U] KOG2058 Ypt/Rab GTPase activating protein 82 2e-15
At2g37290 [U] KOG2058 Ypt/Rab GTPase activating protein 82 3e-15
7299317 [U] KOG2058 Ypt/Rab GTPase activating protein 80 1e-14
Hs4758564_1 [R] KOG1102 Rab6 GTPase activator GAPCenA and relate... 79 3e-14
Hs22062568 [U] KOG2221 PDZ-domain interacting protein EPI64 cont... 76 1e-13
CE28759 [TR] KOG2223 Uncharacterized conserved protein contains ... 75 3e-13
Hs14149985 [R] KOG1102 Rab6 GTPase activator GAPCenA and related... 75 4e-13
SPAC26F1.09 [R] KOG1102 Rab6 GTPase activator GAPCenA and relate... 74 7e-13
Hs20560763 [R] KOG1102 Rab6 GTPase activator GAPCenA and related... 74 9e-13
Hs22066444 [R] KOG1102 Rab6 GTPase activator GAPCenA and related... 73 1e-12
SPBC1778.09 [R] KOG1102 Rab6 GTPase activator GAPCenA and relate... 69 2e-11
At2g39280 [U] KOG2058 Ypt/Rab GTPase activating protein 65 2e-10
ECU11g1700 [R] KOG1102 Rab6 GTPase activator GAPCenA and related... 64 5e-10
CE29557 [U] KOG2058 Ypt/Rab GTPase activating protein 56 1e-07
7290543 [R] KOG1093 Predicted protein kinase (contains TBC and R... 52 3e-06
Hs22062664 [TR] KOG2224 Uncharacterized conserved protein contai... 52 3e-06
>YNL293w [U] KOG2058 Ypt/Rab GTPase activating protein
Length = 633
Score = 565 bits (1457), Expect = e-161
Identities = 287/530 (54%), Positives = 370/530 (69%), Gaps = 43/530 (8%)
Query: 133 EDKTINLDDSGSSDA--LNGIGQLPTPESESRASQLLGNSSLIEDAASIKVKDSHLDRYG 190
ED N D+G+ D ++ P+ ++R L ++ A S + ++H DRYG
Sbjct: 100 EDDDDNNGDNGNEDLEEVHSDDLDLVPDDDNRQRVELEGAASATSANSNGINNTHFDRYG 159
Query: 191 FMKQNQYISEKQYNEWWSEYSKYCIXXXXXXXXXXXXSGLPVDNDSPSRFPSKSEKLKRY 250
F KQN YISE +Y++WW EYS+YC+ SGLPV +DSPSRFPSKSE+LKRY
Sbjct: 160 FKKQNNYISEAEYDKWWVEYSQYCVRRKHKWQLLLEKSGLPVTDDSPSRFPSKSERLKRY 219
Query: 251 VRKGIPAEWRGNAWWYFARGQELLNKNIGVYDKLLTKI------NDPSFTSKDTEIIERD 304
VRKGIPAEWRGNAWW+FARGQE LNKN GVY +LL K+ N +D +IIERD
Sbjct: 220 VRKGIPAEWRGNAWWHFARGQEKLNKNKGVYSQLLRKMKQIKKQNPNEKQVQDLDIIERD 279
Query: 305 LHRTFPDNIHFQRSKVSSEDPLIIKSLRRILKAFAIYNAKIGYCQSMNFLVGLLLLFMDE 364
L+RTFPDNIHFQ S + E P IIKSLRR+L AF++YN KIGYCQSMNFL GLLLLF+DE
Sbjct: 280 LNRTFPDNIHFQSSLHNKEGPPIIKSLRRVLVAFSLYNPKIGYCQSMNFLAGLLLLFLDE 339
Query: 365 ERAFWMLVIMTSRYLPGVHSINLEGVNINQGVLLLCIKEYLPHFWQRIYSNKD--QQHSP 422
ERAFWMLVI+TSRYLPGVH+INLEGVNI+QGVL+LC+KEY+P W I + D Q+++
Sbjct: 340 ERAFWMLVIITSRYLPGVHNINLEGVNIDQGVLMLCVKEYIPEVWSYIKPSIDHHQKNNK 399
Query: 423 GLS----------NKNEFLYKLPPVTLCTASWFMSCFIGVVPIEATLRIWDCLFYEGSHI 472
S KNEFLY+LPP+TLCTASWFMSCF+GVVPIE TLRIWDCLFYE SH
Sbjct: 400 TFSPSNKKVLFNMQKNEFLYRLPPITLCTASWFMSCFVGVVPIETTLRIWDCLFYEESHF 459
Query: 473 LFKMSLAIIELSETNLPKL----------------NHVSSRNSDDEDMELFQAIQTYPRR 516
LFK+SLA+++LSE +L K+ S +D DME+FQ IQT+P+
Sbjct: 460 LFKVSLAVLKLSEHDLSKIKPRNNSLNYSWGSNLNQRGGSMGQEDSDMEIFQVIQTFPKT 519
Query: 517 LINPNDIIDKAIFKRRLRFNALNQEEIERCKKYVISQRAKYKNFQDVMKNETTNS----N 572
L+NPN+I +K IFKRR N L+Q+EI+RC+K+V +QR K+K + +++ N T+ + N
Sbjct: 520 LLNPNEIFEKIIFKRRFNLNRLDQDEIDRCRKFVAAQRLKFKTYGELLGNSTSEADLPIN 579
Query: 573 NKRDSK---LAQELINETFSNEGYGFKKGLNGVNWNNNIKERVRRLSRKR 619
+ D+K + + +NE S+E YGFKK L GV+WNN+IKE+V+++ +K+
Sbjct: 580 DNTDNKGIHITSDAVNEALSSEVYGFKKSLAGVHWNNSIKEKVKQMRKKK 629
>YOL112w [U] KOG2058 Ypt/Rab GTPase activating protein
Length = 492
Score = 417 bits (1073), Expect = e-116
Identities = 199/411 (48%), Positives = 277/411 (66%), Gaps = 31/411 (7%)
Query: 179 IKVKDSHLDRYGFMKQNQYISEKQYNEWWSEYSKYCIXXXXXXXXXXXXSGLPVDNDSPS 238
I + DRYGF K+ +IS+++Y++WW+EY++Y + + + ND+P
Sbjct: 72 IMADPENFDRYGFSKKGYFISQEEYDKWWTEYNRYTERRKKKWENFLLKNKIELHNDNPL 131
Query: 239 RFPSKSEKLKRYVRKGIPAEWRGNAWWYFARGQELLNKNIGVYDKLLTKINDPSFTSKDT 298
+P+++++L ++VRKGIPAEWRGNAWWYFA GQ L+ N+GVYD+L + + + + KD
Sbjct: 132 VYPARTDELSKFVRKGIPAEWRGNAWWYFAGGQRQLDANVGVYDRLKSDCREGAVSGKDM 191
Query: 299 EIIERDLHRTFPDNIHFQRSKVSSEDPLIIKSLRRILKAFAIYNAKIGYCQSMNFLVGLL 358
E IERDL+RTFPDNIHF + + +P II+SLRR+L AF++Y+ IGYCQSMNFLVGLL
Sbjct: 192 EAIERDLYRTFPDNIHFHKESFQNGEPAIIRSLRRVLMAFSVYDKTIGYCQSMNFLVGLL 251
Query: 359 LLFMDEERAFWMLVIMTSRYLPGVHSINLEGVNINQGVLLLCIKEYLPHFWQRIYS---- 414
LLFM+EE+AFWMLVI+T +YLPGV+ +LEG N++QGVL+LCIKEYLP W I S
Sbjct: 252 LLFMEEEKAFWMLVIITGKYLPGVYESDLEGANVDQGVLVLCIKEYLPEIWSHIESSYMN 311
Query: 415 -NKDQQHSPGLSNKNEFLYKLPPVTLCTASWFMSCFIGVVPIEATLRIWDCLFYEGSHIL 473
N G ++ E+L +LP +TLCTASWFMSCF+GVVPIE TLRIWDCLFYE SH L
Sbjct: 312 GNGSTDQISGPASGEEYLCRLPTLTLCTASWFMSCFVGVVPIETTLRIWDCLFYEESHFL 371
Query: 474 FKMSLAIIELSETNL-----PKLNHVSS---------------------RNSDDEDMELF 507
FK++L I++LSE+ KL S + ++ DME+
Sbjct: 372 FKVALGILKLSESEFLESKSQKLFRQYSSYTFGGSNDSDSTFKRLKNKIKTQEEADMEIL 431
Query: 508 QAIQTYPRRLINPNDIIDKAIFKRRLRFNALNQEEIERCKKYVISQRAKYK 558
Q IQ +P+RL+NPNDI +K + K+++ N + QE+I+R ++YV R + +
Sbjct: 432 QVIQNFPKRLLNPNDIFEKVLMKKKVALNGITQEKIDRGREYVAMARNRQR 482
>SPCC4G3.09c [U] KOG2058 Ypt/Rab GTPase activating protein
Length = 635
Score = 312 bits (799), Expect = 1e-84
Identities = 177/415 (42%), Positives = 245/415 (58%), Gaps = 41/415 (9%)
Query: 180 KVKDSHL--DRYGFMKQNQYISEKQYNEWWSEYSKYCIXXXXXXXXXXXXSGLPVDNDSP 237
K K SH D YGF K NQ+ + QYN W+ YS+Y +G+ + SP
Sbjct: 224 KYKPSHSSWDIYGFKKANQFYTVDQYNTWYGPYSRYLERREQRWKLFLQENGIDYIHQSP 283
Query: 238 SRFPSKSEKLKRYVRKGIPAEWRGNAWWYFARGQELLNKNIGVYDKL--LTKINDPSFTS 295
S FPS+S K +R++RKGIP E+RGNAW+Y++ G ELL +N +Y+ L I PS
Sbjct: 284 SIFPSRSAKTQRFIRKGIPPEYRGNAWFYYSGGYELLQRNPKLYETLWRCACIKKPS--- 340
Query: 296 KDTEIIERDLHRTFPDNIHFQR-----------SKVSSEDPLI--IKSLRRILKAFAIYN 342
D+++IERDL+RTFPDN+HF+ S+ SSE+P + I LRR+L FA Y
Sbjct: 341 -DSDLIERDLYRTFPDNVHFRHKSKHSRNSSDASEHSSEEPDVPMISKLRRVLMTFATYL 399
Query: 343 AKIGYCQSMNFLVGLLLLFMDEERAFWMLVIMTSRYLPGVHSINLEGVNINQGVLLLCIK 402
+ GYCQS+NFL G LLFM EE+AFWMLVI +YLP +H NLEG NI+Q VL+ ++
Sbjct: 400 PENGYCQSLNFLAGFFLLFMSEEKAFWMLVITCRKYLPKMHDANLEGANIDQSVLMASVR 459
Query: 403 EYLPHFWQRIYSNKDQQHSPGLSNKNEFLYKLPPVTLCTASWFMSCFIGVVPIEATLRIW 462
E LP W RI N D G+ N+ + KLPP+TL TA+WFMS F+G++P E LR+W
Sbjct: 460 ESLPAVWSRISLNFD-----GIP-VNDIVAKLPPITLVTAAWFMSAFVGILPTETALRVW 513
Query: 463 DCLFYEGSHILFKMSLAIIELSETNLPKLNHVSSRNSDDEDMELFQAIQTYPRRLINPND 522
DC FYEGS +LF +L I+ L E ++ S E E+FQ IQ P+ L++ N
Sbjct: 514 DCFFYEGSKVLFMTALCILRLGEDDI---------KSKSEQTEVFQVIQDLPKSLLDANA 564
Query: 523 IIDKAIFKRRLRFNALNQEEIERCKKYVISQR---AKYKNFQDVMKNETTNSNNK 574
+ F+R R +Q++IER ++ V +R A D K+ + S+++
Sbjct: 565 FL-SLCFRRNFR-RTPSQKDIERRREKVAKKRNSSASKLEMSDSSKHHLSRSSSR 617
>Hs22042713 [R] KOG4347 GTPase-activating protein VRP
Length = 1266
Score = 147 bits (370), Expect = 6e-35
Identities = 94/324 (29%), Positives = 161/324 (49%), Gaps = 60/324 (18%)
Query: 243 KSEKLKRYVRKGIPAEWRGNAWWYFARGQELLNKNIGVYDKLLTKINDPSFTSKDTEIIE 302
++EK + V KGIP RG W + + G Y+ L+ K + TE IE
Sbjct: 504 RTEKTRELVLKGIPESMRGELWLLLSGAINEKATHPGYYEDLVEK--SMGKYNLATEEIE 561
Query: 303 RDLHRTFPDNIHFQRSKVSSEDPLIIKSLRRILKAFAIYNAKIGYCQSMNFLVGLLLLFM 362
RDLHR+ P++ FQ + I +LRR+L A+A N IGYCQ+MN + +LLL+
Sbjct: 562 RDLHRSLPEHPAFQNE-------MGIAALRRVLTAYAFRNPNIGYCQAMNIVTSVLLLYA 614
Query: 363 DEERAFWMLVIMTSRYLPGVHSINLEGVNINQGVLLLCIKEYLPHFWQRIYSNKDQQHSP 422
EE AFW+LV + R LP ++ + G ++QGV ++Y+P +
Sbjct: 615 KEEEAFWLLVALCERMLPDYYNTRVVGALVDQGVFEELARDYVPQLY------------- 661
Query: 423 GLSNKNEFLYKLPPVTLCTASWFMSCFIGVVPIEATLRIWDCLFYEGSHILFKMSLAIIE 482
+ + L ++ + SWF++ F+ V+P E+ + + DC FYEG ++F+++LA+++
Sbjct: 662 ------DCMQDLGVISTISLSWFLTLFLSVMPFESAVVVVDCFFYEGIKVIFQLALAVLD 715
Query: 483 LS---------------------------ETNLPKLNHVSSRNSDD----EDMELFQAIQ 511
+ ++ LP + H+ S SDD ++++F+ I+
Sbjct: 716 ANVDKLLNCKDDGEAMTVLGRYLDSVTNKDSTLPPIPHLHSLLSDDVEPYPEVDIFRLIR 775
Query: 512 T-YPRRLINPNDIIDKAIFKRRLR 534
T Y + D+I++ FK+RL+
Sbjct: 776 TSYEKFGTIRADLIEQMRFKQRLK 799
>Hs5902154 [R] KOG4347 GTPase-activating protein VRP
Length = 897
Score = 139 bits (349), Expect = 2e-32
Identities = 82/246 (33%), Positives = 126/246 (50%), Gaps = 28/246 (11%)
Query: 243 KSEKLKRYVRKGIPAEWRGNAWWYFARGQELLNKNIGVYDKLLTKINDPSFTSKDTEIIE 302
++EK+++ V GIP RG W F+ L + G Y L+ + TE IE
Sbjct: 251 RTEKIRKLVAMGIPESLRGRLWLLFSDAVTDLASHPGYYGNLVEESLGKCCLV--TEEIE 308
Query: 303 RDLHRTFPDNIHFQRSKVSSEDPLIIKSLRRILKAFAIYNAKIGYCQSMNFLVGLLLLFM 362
RDLHR+ P++ FQ I +LRR+L A+A N KIGYCQSMN L +LLL+
Sbjct: 309 RDLHRSLPEHPAFQNETG-------IAALRRVLTAYAHRNPKIGYCQSMNILTSVLLLYT 361
Query: 363 DEERAFWMLVIMTSRYLPGVHSINLEGVNINQGVLLLCIKEYLPHFWQRIYSNKDQQHSP 422
EE AFW+LV + R LP + + G ++Q V IK +LP
Sbjct: 362 KEEEAFWLLVAVCERMLPDYFNHRVIGAQVDQSVFEELIKGHLPEL-------------- 407
Query: 423 GLSNKNEFLYKLPPVTLCTASWFMSCFIGVVPIEATLRIWDCLFYEGSHILFKMSLAIIE 482
E + L + + SWF++ F+ ++P+E+ + + DC FY+G +F++ LA++E
Sbjct: 408 -----AEHMNDLSALASVSLSWFLTLFLSIMPLESAVNVVDCFFYDGIKAIFQLGLAVLE 462
Query: 483 LSETNL 488
+ +L
Sbjct: 463 ANAEDL 468
>At5g15930 [R] KOG1102 Rab6 GTPase activator GAPCenA and related TBC domain
proteins
Length = 356
Score = 132 bits (333), Expect = 1e-30
Identities = 102/342 (29%), Positives = 169/342 (48%), Gaps = 37/342 (10%)
Query: 186 LDRYGFMKQNQYISEKQYNEWWSEYSKYCIXXXXXXXXXXXXSGLPVDNDSPSRFPSKSE 245
+DR+GF+KQ S +++ + S + +G +D K
Sbjct: 20 VDRFGFLKQEHGSSPQRFTKTKSSINYEKEEKRVTKWRKMIGTG---GSDWKHYVRRKPH 76
Query: 246 KLKRYVRKGIPAEWRGNAWWYFARGQELLNKNIGVYDKLLTKINDPSFTSKDTEIIERDL 305
+KR +RKGIP RG W + ++LL N GVY +L+ I + S + D I RD+
Sbjct: 77 VVKRRIRKGIPDCLRGLVWQLISGSRDLLLMNPGVYVQLV--IYETSASELD---IIRDI 131
Query: 306 HRTFPDNIHFQRSKVSSEDPLIIKSLRRILKAFAIYNAKIGYCQSMNFLVGLLLLFMDEE 365
RTFP ++ FQ+ + +SL +LKA+++Y+ +GY Q M F+ GLLLL+M EE
Sbjct: 132 SRTFPSHVFFQKRHGPGQ-----RSLYNVLKAYSVYDRDVGYVQGMGFIAGLLLLYMSEE 186
Query: 366 RAFWMLVIMTSRYLPGVHSINLEGVNINQGVLLLCIKEYLPHFWQRIYSNKDQQHSPGLS 425
AFW+LV + L G +EG+ G+ L +++YL F Q + ++ P L
Sbjct: 187 DAFWLLVAL----LKGAVHSPIEGL-YQAGLPL--VQQYLLQFDQLV-----RELMPKLG 234
Query: 426 NKNEFLYKLPPVTLCTASWFMSCFIGVVPIEATLRIWDCLFYEGSHILFKMSLAIIELSE 485
F ++ ++ + WF++ F +P + LRIWD EG I+FK+ LA+++
Sbjct: 235 --EHFTQEMINPSMYASQWFITVFSYSLPFHSALRIWDVFLAEGVKIVFKVGLALLKHCH 292
Query: 486 TNLPKLNHVSSRNSDDEDMELFQAIQTYPRRLINPNDIIDKA 527
+L KL EL A++ +P ++P+ ++ A
Sbjct: 293 DDLLKLPF----------EELMHALRNFPEDAMDPDTLLPLA 324
>Hs21361485 [U] KOG2221 PDZ-domain interacting protein EPI64 contains TBC
domain
Length = 533
Score = 131 bits (330), Expect = 3e-30
Identities = 78/247 (31%), Positives = 127/247 (50%), Gaps = 27/247 (10%)
Query: 245 EKLKRYVRKGIPAEWRGNAWWYFARGQELLNKNIGVYDKLLTKINDPSFTSKDTEIIERD 304
+K+K RKGIP+ R AW Y + +ELL +N G +++L DP + ++IE+D
Sbjct: 76 QKVKLRCRKGIPSSLRAKAWQYLSNSKELLEQNPGKFEELERAPGDPKWL----DVIEKD 131
Query: 305 LHRTFPDNIHFQRSKVSSEDPLIIKSLRRILKAFAIYNAKIGYCQSMNFLVGLLLLFMDE 364
LHR FP + F + + L RILKA+ IY GYCQ+ + +LL+ M
Sbjct: 132 LHRQFPFHEMFAARGGHGQ-----QDLYRILKAYTIYRPDEGYCQAQAPVAAVLLMHMPA 186
Query: 365 ERAFWMLVIMTSRYLPGVHSINLEGVNINQGVLLLCIKEYLPHFWQRIYSNKDQQHSPGL 424
E+AFW LV + +YLPG +S LE + ++ + ++ P L
Sbjct: 187 EQAFWCLVQICDKYLPGYYSAGLEAIQLDGEIFFALLRRASP-----------------L 229
Query: 425 SNKNEFLYKLPPVTLCTASWFMSCFIGVVPIEATLRIWDCLFYEGSHILFKMSLAIIELS 484
++++ ++ PV T WFM F +P + LR+WD F EG I+F+++L ++ +
Sbjct: 230 AHRHLRRQRIDPVLYMT-EWFMCIFARTLPWASVLRVWDMFFCEGVKIIFRVALVLLRHT 288
Query: 485 ETNLPKL 491
++ KL
Sbjct: 289 LGSVEKL 295
>Hs13994322 [U] KOG2221 PDZ-domain interacting protein EPI64 contains TBC
domain
Length = 508
Score = 131 bits (330), Expect = 3e-30
Identities = 78/241 (32%), Positives = 126/241 (51%), Gaps = 29/241 (12%)
Query: 243 KSEKLKRYVRKGIPAEWRGNAWWYFARGQELLNKNIGVYDKLLTKINDPSFTSKDTEIIE 302
K +K++ +KGIP RG AW Y + G+ L +N G +D+L DP + ++IE
Sbjct: 100 KHKKIRLRCQKGIPPSLRGRAWQYLSGGKVKLQQNPGKFDELDMSPGDPKWL----DVIE 155
Query: 303 RDLHRTFPDNIHF-QRSKVSSEDPLIIKSLRRILKAFAIYNAKIGYCQSMNFLVGLLLLF 361
RDLHR FP + F R +D L R+LKA+ +Y + GYCQ+ + +LL+
Sbjct: 156 RDLHRQFPFHEMFVSRGGHGQQD------LFRVLKAYTLYRPEEGYCQAQAPIAAVLLMH 209
Query: 362 MDEERAFWMLVIMTSRYLPGVHSINLEGVNINQGVLLLCIKEYLPHFWQRIYSNKDQQHS 421
M E+AFW LV + +YLPG +S LE + ++ +L +++ P
Sbjct: 210 MPAEQAFWCLVQICEKYLPGYYSEKLEAIQLDGEILFSLLQKVSP--------------- 254
Query: 422 PGLSNKNEFLYKLPPVTLCTASWFMSCFIGVVPIEATLRIWDCLFYEGSHILFKMSLAII 481
+++K+ K+ P+ T WFM F +P + LR+WD F EG I+F++ L ++
Sbjct: 255 --VAHKHLSRQKIDPLLYMT-EWFMCAFSRTLPWSSVLRVWDMFFCEGVKIIFRVGLVLL 311
Query: 482 E 482
+
Sbjct: 312 K 312
>7296423 [R] KOG4347 GTPase-activating protein VRP
Length = 1291
Score = 131 bits (329), Expect = 3e-30
Identities = 87/281 (30%), Positives = 137/281 (47%), Gaps = 36/281 (12%)
Query: 253 KGIPAEWRGNAWWYFARGQELLNKNIGVYDKLLTKINDPSFTSKDTEIIERDLHRTFPDN 312
+GIP + R W F+ N G+Y+ L+ K EI +RDL R+ P++
Sbjct: 461 EGIPDKLRQEIWLIFSGAIHDKEMNPGLYEDLVEKAACIKNCFAHDEI-DRDLPRSLPEH 519
Query: 313 IHFQRSKVSSEDPLIIKSLRRILKAFAIYNAKIGYCQSMNFLVGLLLLFMDEERAFWMLV 372
FQ + I +LRR+L+A+A+ N ++GYCQ+MN + + LLF DEE AFWML
Sbjct: 520 PAFQSTDG-------IGALRRVLQAYALRNPQVGYCQAMNIVSSVFLLFCDEENAFWMLA 572
Query: 373 IMTSRYLPGVHSINLEGVNINQGVLLLCIKEYLPHFWQRIYSNKDQQHSPGLSNKNEFLY 432
+ LP + + G I+QGVL ++ +LP + + L
Sbjct: 573 SLCENLLPDYYKDKVVGAQIDQGVLNELVETHLP-------------------DLHGHLE 613
Query: 433 KLPPVTLCTASWFMSCFIGVVPIEATLRIWDCLFYEGSHILFKMSLAIIELSETNLPKLN 492
+L + + + SWF++ F+ V+ E++L I DC FYEG+ I+F +SL IIE + L
Sbjct: 614 QLGVIKMISISWFLTIFMSVISYESSLHILDCFFYEGAKIIFMISLQIIEWNRDKLLIC- 672
Query: 493 HVSSRNSDDEDMELFQAIQTYPRRLINPNDIIDKAIFKRRL 533
+D E +Q Y + NP + KR++
Sbjct: 673 --------QDDGEAMLVLQNYLEGVYNPEYQVPPTTDKRKM 705
>Hs11034851 [TR] KOG2222 Uncharacterized conserved protein contains TBC SH3 and
RUN domains
Length = 777
Score = 129 bits (325), Expect = 1e-29
Identities = 94/277 (33%), Positives = 133/277 (47%), Gaps = 35/277 (12%)
Query: 243 KSEKLKRYVRKGIPAEWRGNAWWYFARG-QELLNKNIGVYDKLLTKINDPSFTSKDTEII 301
+SEKL+ V GIP R W + Q+ N + + + ND + +K I
Sbjct: 103 RSEKLRSLVLAGIPHGMRPQLWMRLSGALQKKRNSELSYREIVKNSSNDETIAAKQ---I 159
Query: 302 ERDLHRTFPDNIHFQRSKVSSEDPLIIKSLRRILKAFAIYNAKIGYCQSMNFLVGLLLLF 361
E+DL RT P N F +S + + LRR+L+A A +IGYCQ + LLLF
Sbjct: 160 EKDLLRTMPSNACF-----ASMGSIGVPRLRRVLRALAWLYPEIGYCQGTGMVAACLLLF 214
Query: 362 MDEERAFWMLVIMTSRYLPGVH-SINLEGVNINQGVLLLCIKEYLPHFWQRIYSNKDQQH 420
++EE AFWM+ + LP + S L GV +Q VL I +YLP + + Q+H
Sbjct: 215 LEEEDAFWMMSAIIEDLLPASYFSTTLLGVQTDQRVLRHLIVQYLPRLDKLL-----QEH 269
Query: 421 SPGLSNKNEFLYKLPPVTLCTASWFMSCFIGVVPIEATLRIWDCLFYEGSHILFKMSLAI 480
LS L T WF++ F VV I+ LRIWD FYEGS +LF+++L +
Sbjct: 270 DIELS-------------LITLHWFLTAFASVVDIKLLLRIWDLFFYEGSRVLFQLTLGM 316
Query: 481 IELSETNLPK-------LNHVSSRNSDDEDMELFQAI 510
+ L E L + N +S S ED EL +
Sbjct: 317 LHLKEEELIQSENSASIFNTLSDIPSQMEDAELLLGV 353
>Hs17485595 [R] KOG4347 GTPase-activating protein VRP
Length = 796
Score = 127 bits (320), Expect = 4e-29
Identities = 80/249 (32%), Positives = 126/249 (50%), Gaps = 31/249 (12%)
Query: 243 KSEKLKRYVRKGIPAEWRGNAWWYFARGQELLNKNIGVYDKLLTKINDPSFTSKDTEIIE 302
+++K + V +GIP RG W F+ + N Y +++ + + TE IE
Sbjct: 476 RTKKTRDLVVRGIPETLRGELWMLFSGAVNDMATNPDYYTEVVEQ--SLGTCNLATEEIE 533
Query: 303 RDLHRTFPDNIHFQRSKVSSEDPLIIKSLRRILKAFAIYNAKIGYCQSMNFLVGLLLLFM 362
RDL R+ P++ FQ I +LRR+L A+A N KIGYCQ+MN L +LLL+
Sbjct: 534 RDLRRSLPEHPAFQSDTG-------ISALRRVLTAYAYRNPKIGYCQAMNILTSVLLLYA 586
Query: 363 DEERAFWMLVIMTSRYLPGVHSINLEGVNINQGVLLLCIKEYLPHFWQRIYSNKDQQHSP 422
EE AFW+LV + R LP + + G ++Q V I+++LP
Sbjct: 587 KEEEAFWLLVAVCERMLPDYFNRRIIGALVDQAVFEELIRDHLPQL-------------- 632
Query: 423 GLSNKNEFLYKLPPVTLCTASWFMSCFIGVVPIEATLRIWDCLFYEGSHILFKMSLAIIE 482
E + + + + SWF++ FI V+PIE+ + + DC FY+G + ++ LAI++
Sbjct: 633 -----TEHMTDMTFFSSVSLSWFLTLFISVLPIESAVNVVDCFFYDGIKAILQLGLAILD 687
Query: 483 LSETNLPKL 491
NL KL
Sbjct: 688 Y---NLDKL 693
>CE19171 [R] KOG4347 GTPase-activating protein VRP
Length = 1270
Score = 127 bits (319), Expect = 5e-29
Identities = 82/284 (28%), Positives = 142/284 (49%), Gaps = 37/284 (13%)
Query: 243 KSEKLKRYVRKGIPAEWRGNAWWYFARGQELLNKNIGVYDKLLTKINDPSFTSKDTEIIE 302
++ +L R + +G+P + RG W + + N G Y +LL K + S E IE
Sbjct: 501 RTVELHRLLLEGVPLQLRGQIWMVCSGAAAEMALNPGYYRELLHK--NQGVYSVALEEIE 558
Query: 303 RDLHRTFPDNIHFQRSKVSSEDPLIIKSLRRILKAFAIYNAKIGYCQSMNFLVGLLLLFM 362
RDLHR+ P++ FQ+ I +LRRIL A+A N IGYCQ+MN + +LLLF
Sbjct: 559 RDLHRSLPEHPAFQQGPG-------IDALRRILTAYAFRNPNIGYCQAMNIVGSVLLLFT 611
Query: 363 DEERAFWMLVIMTSRYLPGVHSINLEGVNINQGVLLLCIKEYLPHFWQRIYSNKDQQHSP 422
EE AFW+LV + R LP ++ + G ++QGV ++ LP +
Sbjct: 612 KEEEAFWLLVAVCERLLPDYYNTKVVGALVDQGVFSELVERLLPTVGAQ----------- 660
Query: 423 GLSNKNEFLYKLPPVTLCTASWFMSCFIGVVPIEATLRIWDCLFYEGSHILFKMSLAIIE 482
L +L + SWF++ F+ + +A +RI D F+EG+ ++F+++L +++
Sbjct: 661 --------LTRLGLDDMVALSWFLTVFLSAIKFDAAVRILDLFFFEGARLMFQVALEMLK 712
Query: 483 LSETNLPKLNHVSSRNSDDEDMELFQAIQTYPRRLINPNDIIDK 526
+E + SR +D E+ ++ Y + + ++++
Sbjct: 713 ENEKLI-----CESR----DDGEILMSLAKYTESIYEGDTVVER 747
>CE18397 [R] KOG4347 GTPase-activating protein VRP
Length = 1268
Score = 127 bits (319), Expect = 5e-29
Identities = 82/284 (28%), Positives = 142/284 (49%), Gaps = 37/284 (13%)
Query: 243 KSEKLKRYVRKGIPAEWRGNAWWYFARGQELLNKNIGVYDKLLTKINDPSFTSKDTEIIE 302
++ +L R + +G+P + RG W + + N G Y +LL K + S E IE
Sbjct: 501 RTVELHRLLLEGVPLQLRGQIWMVCSGAAAEMALNPGYYRELLHK--NQGVYSVALEEIE 558
Query: 303 RDLHRTFPDNIHFQRSKVSSEDPLIIKSLRRILKAFAIYNAKIGYCQSMNFLVGLLLLFM 362
RDLHR+ P++ FQ+ I +LRRIL A+A N IGYCQ+MN + +LLLF
Sbjct: 559 RDLHRSLPEHPAFQQGPG-------IDALRRILTAYAFRNPNIGYCQAMNIVGSVLLLFT 611
Query: 363 DEERAFWMLVIMTSRYLPGVHSINLEGVNINQGVLLLCIKEYLPHFWQRIYSNKDQQHSP 422
EE AFW+LV + R LP ++ + G ++QGV ++ LP +
Sbjct: 612 KEEEAFWLLVAVCERLLPDYYNTKVVGALVDQGVFSELVERLLPTVGAQ----------- 660
Query: 423 GLSNKNEFLYKLPPVTLCTASWFMSCFIGVVPIEATLRIWDCLFYEGSHILFKMSLAIIE 482
L +L + SWF++ F+ + +A +RI D F+EG+ ++F+++L +++
Sbjct: 661 --------LTRLGLDDMVALSWFLTVFLSAIKFDAAVRILDLFFFEGARLMFQVALEMLK 712
Query: 483 LSETNLPKLNHVSSRNSDDEDMELFQAIQTYPRRLINPNDIIDK 526
+E + SR +D E+ ++ Y + + ++++
Sbjct: 713 ENEKLI-----CESR----DDGEILMSLAKYTESIYEGDTVVER 747
>7300111 [U] KOG2058 Ypt/Rab GTPase activating protein
Length = 299
Score = 124 bits (311), Expect = 4e-28
Identities = 77/236 (32%), Positives = 118/236 (49%), Gaps = 31/236 (13%)
Query: 246 KLKRYVRKGIPAEWRGNAWWYFARGQELLNKNIGVYDKLLTKINDPSFTSKDTEIIERDL 305
KLKRY+RKGIP +R + W + ++ ++ LL +P F + ++ I DL
Sbjct: 31 KLKRYIRKGIPGPYRPDVWMKISGAAAAQRRSPDLFRNLLR--TEP-FDKEISDSISIDL 87
Query: 306 HRTFPDNIHFQRSKVSSEDPLIIKSLRRILKAFAIYNAKIGYCQSMNFLVGLLLLFM-DE 364
RTFPDNIHF K + L IL A+A +N +GYCQ +N++ GLLL+ DE
Sbjct: 88 PRTFPDNIHFDMKK---------QRLYNILIAYAHHNRDVGYCQGLNYIAGLLLIVTDDE 138
Query: 365 ERAFWMLVIMTSRYLPGVHSINLEGVNINQGVLLLCIKEYLPHFWQRIYSNKDQQHSPGL 424
E++FW+L + +P HS N+ + + V + +P +H L
Sbjct: 139 EKSFWLLKHIVENIVPQYHSHNMANLLRDLAVFRELVIRRIPAV---------NRHVDNL 189
Query: 425 SNKNEFLYKLPPVTLCTASWFMSCFIGVVPIEATLRIWDCLFYEGSHILFKMSLAI 480
P + + WF+ F V+P+E LRIWDC+F EG I+F+ +L +
Sbjct: 190 G---------LPYPVIASKWFICIFAEVLPVETVLRIWDCVFAEGYKIVFRAALTM 236
>Hs13376023 [U] KOG2058 Ypt/Rab GTPase activating protein
Length = 257
Score = 122 bits (307), Expect = 1e-27
Identities = 74/225 (32%), Positives = 121/225 (52%), Gaps = 33/225 (14%)
Query: 274 LNKNIGVYDKLLTKINDPSFTSKDTEIIERDLHRTFPDNIHFQRSKVSSEDPLIIKSLRR 333
+++N G Y +LL +P + I DL+RTFPDN+ F+++ DP + ++L
Sbjct: 1 MDQNPGYYHQLLQGERNPRLE----DAIRTDLNRTFPDNVKFRKTT----DPCLQRTLYN 52
Query: 334 ILKAFAIYNAKIGYCQSMNFLVGLLLLFMD-EERAFWMLVIMTSRYLPGVHSINLEGVNI 392
+L A+ +N +GYCQ MNF+ G L+L + EE +FW+L + R LP +S + G+
Sbjct: 53 VLLAYGHHNQGVGYCQGMNFIAGYLVLITNNEEESFWLLDALVGRILPDYYSPAMLGLKT 112
Query: 393 NQGVLLLCIKEYLPHFWQRIYSNKDQQHSPGLSNKNEFLYKLPPVTLCTASWFMSCFIGV 452
+Q VL ++ LP L + L+ TL + WF+ F+ +
Sbjct: 113 DQEVLGELVRAKLPAVG-------------ALMERLGVLW-----TLLVSRWFICLFVDI 154
Query: 453 VPIEATLRIWDCLFYEGSHILFKMSLAIIE------LSETNLPKL 491
+P+E LRIWDCLF EGS I+F+++L +I+ L T++P +
Sbjct: 155 LPVETVLRIWDCLFNEGSKIIFRVALTLIKQHQELILEATSVPDI 199
>7299972 [TR] KOG2222 Uncharacterized conserved protein contains TBC SH3 and
RUN domains
Length = 804
Score = 121 bits (303), Expect = 4e-27
Identities = 86/253 (33%), Positives = 124/253 (48%), Gaps = 28/253 (11%)
Query: 243 KSEKLKRYVRKGIPAEWRGNAWWYFARGQELLNKNIGVY-DKLLTKINDPSFTSKDTEII 301
++EKL+ VR+GIP R W + K+ Y D + ND TSK I
Sbjct: 153 RTEKLRNMVRQGIPHTLRAQMWMRLSGALAKKQKSETSYHDIVKASSNDQLMTSKQ---I 209
Query: 302 ERDLHRTFPDNIHFQRSKVSSEDPLIIKSLRRILKAFAIYNAKIGYCQSMNFLVGLLLLF 361
E+DL R P N F S+ + I LRRIL+ A IGYCQ +V LLLF
Sbjct: 210 EKDLLRILPTNACF-----SNPNGTGIPRLRRILRGIAWLFPDIGYCQGTGVIVACLLLF 264
Query: 362 MDEERAFWMLVIMTSRYLPG-VHSINLEGVNINQGVLLLCIKEYLPHFWQRIYSNKDQQH 420
M+EE AFWM+ + LP +S L G+ +Q V+ I YL + + ++H
Sbjct: 265 MEEENAFWMMATIVEDLLPASYYSSTLLGIQADQRVMHTLIANYLSSVDESL-----RKH 319
Query: 421 SPGLSNKNEFLYKLPPVTLCTASWFMSCFIGVVPIEATLRIWDCLFYEGSHILFKMSLAI 480
LS L T WF++ F VV ++ +RIWD FYEGS +LF+++L +
Sbjct: 320 DIELS-------------LITLHWFLTLFANVVHMKILVRIWDWFFYEGSIVLFQLTLGM 366
Query: 481 IELSETNLPKLNH 493
+++ E +L L +
Sbjct: 367 LKVKEQDLKHLEN 379
>At3g02460 [R] KOG1102 Rab6 GTPase activator GAPCenA and related TBC domain
proteins
Length = 304
Score = 120 bits (301), Expect = 6e-27
Identities = 91/303 (30%), Positives = 152/303 (50%), Gaps = 25/303 (8%)
Query: 186 LDRYGFMKQNQYISEKQYNEWWSEYSKYCIXXXXXXXXXXXXSGLPVDNDSPSRFPSKSE 245
+DR+GF+KQ S +++++ + S G+ +D K
Sbjct: 21 VDRFGFLKQEHANSPERFSKSKTTSSTDHDREERKVRKWRKMIGVG-GSDWKHYVRRKPN 79
Query: 246 KLKRYVRKGIPAEWRGNAWWYFARGQELLNKNIGVYDKLLTKINDPSFTSKDTEIIERDL 305
++R +RKGIP RG W + ++LL N GVY++L+ I + S + D I RD+
Sbjct: 80 VVRRRIRKGIPDCLRGLVWQLISGSRDLLLMNPGVYEQLV--IYETSASELD---IIRDI 134
Query: 306 HRTFPDNIHFQRSKVSSEDPLIIKSLRRILKAFAIYNAKIGYCQSMNFLVGLLLLFMDEE 365
RTFP ++ FQ+ + +SL +LKA+++Y+ +GY Q M F+ GLLLL+M EE
Sbjct: 135 SRTFPSHVFFQKRHGPGQ-----RSLYNVLKAYSVYDRDVGYVQGMGFIAGLLLLYMSEE 189
Query: 366 RAFWMLVIMTSRYLPGVHSINLEGVNINQGVLLLCIKEYLPHFWQRIYSNKDQQHSPGLS 425
AFW+LV + L G +EG+ + G+ L +++YL + ++ P L
Sbjct: 190 DAFWLLVAL----LKGAVHAPMEGL-YHAGLPL--VQQYLFQLESLV-----KELIPKLG 237
Query: 426 NKNEFLYKLPPVTLCTASWFMSCFIGVVPIEATLRIWDCLFYEGSHILFKMSLAIIELSE 485
F ++ ++ + WF++ F P LRIWD EG I+FK+ LA+++ +
Sbjct: 238 --EHFTQEMINPSMYASQWFITVFSYSFPFPLALRIWDVFLSEGVKIVFKVGLALLKYCQ 295
Query: 486 TNL 488
L
Sbjct: 296 DEL 298
>YGR100w [R] KOG4347 GTPase-activating protein VRP
Length = 950
Score = 119 bits (299), Expect = 1e-26
Identities = 73/241 (30%), Positives = 126/241 (51%), Gaps = 27/241 (11%)
Query: 248 KRYVRKGIPAEWRGNAWWYFARGQELLNKNIGVYDKLLTKINDPSFTSKDTEIIERDLHR 307
++ +R G+P RG W + + N G Y+++L + + TS+ + IE+DL R
Sbjct: 238 RKLIRIGVPNRMRGEIWELCSGAMYMRYANSGEYERILNE--NAGKTSQAIDEIEKDLKR 295
Query: 308 TFPDNIHFQRSKVSSEDPLIIKSLRRILKAFAIYNAKIGYCQSMNFLVGLLLLFMDEERA 367
+ P+ +Q + I+ LR +L A++ N +GYCQ+MN +V L+FM EE+A
Sbjct: 296 SLPEYSAYQTEEG-------IQRLRNVLTAYSWKNPDVGYCQAMNIVVAGFLIFMSEEQA 348
Query: 368 FWMLVIMTSRYLPGVHSINLEGVNINQGVLLLCIKEYLPHFWQRIYSNKDQQHSPGLSNK 427
FW L + Y+PG +S + G ++Q V +++ +P W+ I QH LS
Sbjct: 349 FWCLCNLCDIYVPGYYSKTMYGTLLDQRVFESFVEDRMPVLWEYIL-----QHDIQLS-- 401
Query: 428 NEFLYKLPPVTLCTASWFMSCFIGVVPIEATLRIWDCLFYEGSHILFKMSLAIIELSETN 487
+ LP WF+S F +P+E +RI D F GS LF+++LA+++++ +
Sbjct: 402 ---VVSLP--------WFLSLFFTSMPLEYAVRIMDIFFMNGSITLFQVALAVLKINADD 450
Query: 488 L 488
+
Sbjct: 451 I 451
>7299471 [U] KOG2221 PDZ-domain interacting protein EPI64 contains TBC
domain
Length = 363
Score = 118 bits (295), Expect = 3e-26
Identities = 81/252 (32%), Positives = 126/252 (49%), Gaps = 30/252 (11%)
Query: 235 DSPSRFPSKS-EKLKRYVRKGIPAEWRGNAWWYFARGQELLNKNIGVYDKLLTKINDPSF 293
D+ S + SK+ +K++ RKGIP R AW+Y + L KN VY++LL K +P+
Sbjct: 57 DNWSIYMSKNYKKIRDRCRKGIPKSVRPKAWFYLSGAYLLKKKNPNVYNELLEKPGNPT- 115
Query: 294 TSKDTEIIERDLHRTFPDNIHF-QRSKVSSEDPLIIKSLRRILKAFAIYNAKIGYCQSMN 352
E I++D HR FP + F KV + L +LKA++IYN K+G+CQ+
Sbjct: 116 ---TIEEIKKDKHRQFPFHEMFLDEQKVGQIE------LFNVLKAYSIYNPKVGFCQAQA 166
Query: 353 FLVGLLLLFMDEERAFWMLVIMTSRYLPGVHSINLEGVNINQGVLLLCIKEYLPHFWQRI 412
+ LL+ + E AFW+ V + YL LE + + G+L +K+ P ++ +
Sbjct: 167 PIAAFLLMHLPAEDAFWVFVSVCDVYLQDYFIPGLEVIQNDAGILEGLLKKTCPPVYRHL 226
Query: 413 YSNKDQQHSPGLSNKNEFLYKLPPVTLCTASWFMSCFIGVVPIEATLRIWDCLFYEGSHI 472
Q+H K+ P+ T WF+ +P E LR+WDC EG +
Sbjct: 227 -----QKH------------KVEPLLYMT-DWFLCAMTRTLPWETLLRVWDCFLAEGIRV 268
Query: 473 LFKMSLAIIELS 484
+FK++L II S
Sbjct: 269 IFKVALVIIGAS 280
>Hs7661864 [R] KOG1102 Rab6 GTPase activator GAPCenA and related TBC domain
proteins
Length = 828
Score = 117 bits (292), Expect = 7e-26
Identities = 85/266 (31%), Positives = 126/266 (46%), Gaps = 32/266 (12%)
Query: 244 SEKLKRYVRKGIPAEWRGNAWWYFARGQELLNKNIGVYDKLLTKINDPSFTSKDTEIIER 303
+EK R + KGIP + RG W ++ + +Y KL + S D I+
Sbjct: 90 TEKFHRRIYKGIPLQLRGEVWALLLEIPKMKEETRDLYSKLKHRARG---CSPDIRQIDL 146
Query: 304 DLHRTFPDNIHFQ-RSKVSSEDPLIIKSLRRILKAFAIYNAKIGYCQSMNFLVGLLLLFM 362
D++RTF D+I F+ R V + SL +L A++IYN ++GYCQ M+ + LLL++M
Sbjct: 147 DVNRTFRDHIMFRDRYGVKQQ------SLFHVLAAYSIYNTEVGYCQGMSQITALLLMYM 200
Query: 363 DEERAFWMLVIMTSRYLPGVHSINLEGVNINQGVLLLCIKEYLPHFWQRIYSNKDQQHSP 422
+EE AFW LV + S +H ++G LL +E+ + S K +QH
Sbjct: 201 NEEDAFWALVKLFSGPKHAMHGFFVQGF-----PKLLRFQEHHEKILNKFLS-KLKQHLD 254
Query: 423 GLSNKNEFLYKLPPVTLCTASWFMSCFIGVVPIEATLRIWDCLFYEGSHILFKMSLAIIE 482
F T WF CF+ P LRIWD +EG +L MS I++
Sbjct: 255 SQEIYTSFY---------TMKWFFQCFLDRTPFTLNLRIWDIYIFEGERVLTAMSYTILK 305
Query: 483 LSETNLPKLNHVSSRNSDDEDMELFQ 508
L + +L KL S +E +E FQ
Sbjct: 306 LHKKHLMKL-------SMEELVEFFQ 324
>Hs22056446 [U] KOG2058 Ypt/Rab GTPase activating protein
Length = 788
Score = 116 bits (291), Expect = 9e-26
Identities = 86/280 (30%), Positives = 139/280 (48%), Gaps = 38/280 (13%)
Query: 244 SEKLKRYVRKGIPAEWRGNAW-WYFARGQELLNKNI--GVYDKLLTKINDPSFTSKDTEI 300
S +LK +R GIP E R W W R N G + LL K + + ++
Sbjct: 526 SPELKNLIRAGIPHEHRSKVWKWCVDRHTRKFKDNTEPGHFQTLLQKALEKQ--NPASKQ 583
Query: 301 IERDLHRTFPDNIHFQRSKVSSEDPLIIKSLRRILKAFAIYNAKIGYCQSMNFLVGLLLL 360
IE DL RT P+N H+ S +SE I+ LR +L AF+ N IGYCQ +N LV + LL
Sbjct: 584 IELDLLRTLPNNKHY--SCPTSEG---IQKLRNVLLAFSWRNPDIGYCQGLNRLVAVALL 638
Query: 361 FMDEERAFWMLVIMTSRYLP-GVHSINLEGVNINQGVLLLCIKEYLPHFWQRIYSNKDQQ 419
++++E AFW LV + ++P ++ L G ++Q V + E LP R++ + +Q
Sbjct: 639 YLEQEDAFWCLVTIVEVFMPRDYYTKTLLGSQVDQRVFRDLMSEKLP----RLHGHFEQ- 693
Query: 420 HSPGLSNKNEFLYKLPPVTLCTASWFMSCFIGVVPIEATLRIWDCLFYEGSHILFKMSLA 479
YK+ TL T +WF+ F+ V + +IWD YEG ++F+ +LA
Sbjct: 694 ------------YKV-DYTLITFNWFLVVFVDSVVSDILFKIWDSFLYEGPKVIFRFALA 740
Query: 480 IIELSETNLPKLNHVSSRNSDDEDMELFQAIQTYPRRLIN 519
+ + E + KL + M +F+ ++ + R +++
Sbjct: 741 LFKYKEEEILKL---------QDSMSIFKYLRYFTRTILD 771
>Hs8922167 [U] KOG2058 Ypt/Rab GTPase activating protein
Length = 468
Score = 116 bits (290), Expect = 1e-25
Identities = 86/315 (27%), Positives = 149/315 (47%), Gaps = 43/315 (13%)
Query: 244 SEKLKRYVRKGIPAEWRGNAWWYFARGQELLNKNIGVYDKLLTKINDPSFTSKDTEIIER 303
S +LK+ +R G+P E R W + + G Y +LL++ + IE
Sbjct: 155 SAELKQLLRAGVPREHRPRVWRWLVHLRVQHLHTPGCYQELLSRGQAREHPA--ARQIEL 212
Query: 304 DLHRTFPDNIHFQRSKVSSEDPLIIKSLRRILKAFAIYNAKIGYCQSMNFLVGLLLLFMD 363
DL+RTFP+N HF S D LRR+L AF+ N IGYCQ +N L + LL ++
Sbjct: 213 DLNRTFPNNKHFTCPTSSFPD-----KLRRVLLAFSWQNPTIGYCQGLNRLAAIALLVLE 267
Query: 364 EER-AFWMLVIMTSRYLPGVHSIN-LEGVNINQGVLLLCIKEYLPHFWQRIYSNKDQQHS 421
EE AFW LV + +P + N L ++Q VL + E LP R+ ++ Q H
Sbjct: 268 EEESAFWCLVAIVETIMPADYYCNTLTASQVDQRVLQDLLSEKLP----RLMAHLGQHHV 323
Query: 422 PGLSNKNEFLYKLPPVTLCTASWFMSCFIGVVPIEATLRIWDCLFYEGSHILFKMSLAII 481
++L T +WF+ F + LR+WD YEG+ ++F+ +LAI
Sbjct: 324 D--------------LSLVTFNWFLVVFADSLISNILLRVWDAFLYEGTKVVFRYALAIF 369
Query: 482 ELSETNLPKLNHVSSRNSDDEDMELFQAIQTYPRRLINPNDIIDKAIFKRRLRFNALNQE 541
+ +E + +L + +E++Q ++ + + + N +++ + FN +N
Sbjct: 370 KYNEKEILRLQN---------GLEIYQYLRFFTKTISNSRKLMN-------IAFNDMNPF 413
Query: 542 EIERCKKYVISQRAK 556
+++ ++ + R +
Sbjct: 414 RMKQLRQLRMVHRER 428
>At3g07890 [U] KOG2058 Ypt/Rab GTPase activating protein
Length = 389
Score = 114 bits (286), Expect = 3e-25
Identities = 85/286 (29%), Positives = 133/286 (45%), Gaps = 37/286 (12%)
Query: 247 LKRYVRKGIPAEWRGNAWWYFARGQELLNKNIGVYDKLLTKINDPSFTSKDTEIIERDLH 306
LKR +RKGIP R W+ + + + Y LTK + T T I+ DL
Sbjct: 98 LKRLIRKGIPPVLRPKVWFSLSGAAKKKSTVPESYYSDLTKAVEGMVTPA-TRQIDHDLP 156
Query: 307 RTFPDNIHFQRSKVSSEDPLIIKSLRRILKAFAIYNAKIGYCQSMNFLVGLLLLFMD-EE 365
RTFP + + P +LRR+L ++ ++ +GYCQ +N++ LLLL M EE
Sbjct: 157 RTFPGHPWL-------DTPEGHAALRRVLVGYSFRDSDVGYCQGLNYVAALLLLVMKTEE 209
Query: 366 RAFWMLVIMTSRYLP-GVHSINLEGVNINQGVLLLCIKEYLPHFWQRIYSNKDQQHSPGL 424
AFWML ++ L ++ NL G ++ Q V K+ L RI ++ +
Sbjct: 210 DAFWMLAVLLENVLVRDCYTTNLSGCHVEQRVF----KDLLAQKCSRIATHLEDMGFD-- 263
Query: 425 SNKNEFLYKLPPVTLCTASWFMSCFIGVVPIEATLRIWDCLFYEGSHILFKMSLAIIELS 484
V+L WF+ F +P E TLR+WD LFYEG+ +LF +LAI ++
Sbjct: 264 ------------VSLVATEWFLCLFSKSLPSETTLRVWDVLFYEGAKVLFHAALAIFKMK 311
Query: 485 ETNLPKLNHVSSRNSDDEDMELFQAIQTYPRRLINPNDIIDKAIFK 530
E L + V ++ +Q +L +P++++ A K
Sbjct: 312 ENELLMTHQVG---------DVINILQKTSHQLFDPDELLTVAFEK 348
>CE08508 [U] KOG2058 Ypt/Rab GTPase activating protein
Length = 1244
Score = 114 bits (285), Expect = 4e-25
Identities = 79/256 (30%), Positives = 115/256 (44%), Gaps = 30/256 (11%)
Query: 240 FPSKSEKLKRYVRKGIPAEWRGNAWWYFARGQELLNKNI--GVYDKLLTKI----NDPSF 293
F + + K RKGIP R W Q KN+ Y + L I ++ ++
Sbjct: 361 FIDLTPETKIMCRKGIPNSLRATVWKILINQQVEDLKNVYGKYYYRNLCNIQGGEDEKTY 420
Query: 294 TSKDTEIIERDLHRTFPDNIHFQRSKVSSEDPLIIKSLRRILKAFAIYNAKIGYCQSMNF 353
+ + I DL RT P+N+HF + + L ++L AF ++N++IGYCQ MNF
Sbjct: 421 SDVHQKQINLDLLRTMPNNVHFMSANSKG-----VTQLLQVLHAFCLHNSQIGYCQGMNF 475
Query: 354 LVGLLLLFMDEERAFWMLVIMTSRYLPGVH-SINLEGVNINQGVLLLCIKEYLPHFWQRI 412
L LLF+ E AFW L+ +T RY + NL G +Q VL ++ P
Sbjct: 476 LAATALLFVGPEDAFWFLIAVTERYFDKTYFDSNLTGAQADQEVLKGLLEVQHP------ 529
Query: 413 YSNKDQQHSPGLSNKNEFLYKLPPVTLCTASWFMSCFIGVVPIEATLRIWDCLFYEGSHI 472
K +H L V T +WF+S F VP LRIWDC EG +
Sbjct: 530 ---KIMKHLKSLD---------IDVASFTLNWFISLFFDAVPFNTLLRIWDCFLLEGPKV 577
Query: 473 LFKMSLAIIELSETNL 488
LF+ ++ +I E +
Sbjct: 578 LFRFAIVLIGKHEEEI 593
>7303241 [R] KOG1102 Rab6 GTPase activator GAPCenA and related TBC domain
proteins
Length = 457
Score = 114 bits (285), Expect = 4e-25
Identities = 80/297 (26%), Positives = 141/297 (46%), Gaps = 47/297 (15%)
Query: 238 SRFPSKSEKLKRYVRKGIPAEWRGNAWWYFARGQELLNKNIGVYDKLLTKINDPSFTSKD 297
+++P +KL + V KGIP R AW Q+ +N N GVY ++L S +
Sbjct: 87 NQWPPPQDKLHKRVYKGIPDRVRMVAWNKLLDIQQSINNNAGVYLRMLQLARK---YSTE 143
Query: 298 TEIIERDLHRTFPDNIHFQRSKVSSEDPLIIKSLRRILKAFAIYNAKIGYCQSMNFLVGL 357
T I+ D++R F DN+ F R + S + SL +L A++IYN+++GYCQ M + G+
Sbjct: 144 TRQIDADVNRQFRDNLAF-RERYSVKQC----SLFNVLNAYSIYNSELGYCQGMACVAGV 198
Query: 358 LLLFMDEERAFWMLVIMTSRYLPGVHSINLEG-------VNINQGVLLLCIKEYLPHFWQ 410
LLL++ EE AFW L + + G+H + +EG ++ + ++ +++ HF +
Sbjct: 199 LLLYLHEEEAFWALNTLITDQKYGMHGLFIEGFPKLTRFIDHHDRIMSKIMRKLHKHFTK 258
Query: 411 RIYSNKDQQHSPGLSNKNEFLYKLPPVTLCTASWFMSCFIGVVPIEATLRIWDCLFYEGS 470
N + LY + WF F+ VP +LR+WD +G
Sbjct: 259 H--------------NVDALLYAI--------KWFFVVFVERVPFSLSLRVWDIFMLDGD 296
Query: 471 HILFKMSLAIIELSETNLPKLNHVSS----------RNSDDEDMELFQAIQTYPRRL 517
++ M++ I+ L + L +L + + +N D + QA++ ++L
Sbjct: 297 RVILSMAITILYLHKDELLRLKDMDAIIEYLQVRLHKNFGYSDDDAIQALERVMKKL 353
>At3g55020 [U] KOG2058 Ypt/Rab GTPase activating protein
Length = 814
Score = 113 bits (283), Expect = 7e-25
Identities = 86/279 (30%), Positives = 133/279 (46%), Gaps = 51/279 (18%)
Query: 228 SGLPVDND-SPSRFPSKSEKLKRYVRKGIPAEWRGNAWWYFARGQELLNKNIGVYDKLLT 286
SG+PV D SP E+L+ +R G+P RG W F ++ K+ Y LL
Sbjct: 217 SGIPVAADASPLSTCPWKEELEVLIRGGVPMALRGELWQAFVGVRKRRCKDY--YQNLLA 274
Query: 287 K--------------INDPSFTSKDTEI-------IERDLHRTFPDNIHFQRSKVSSEDP 325
++D +++ + IE+DL RTFP + + D
Sbjct: 275 ADGSVNTIEQEDMQHVDDKGSSTESIAVVEKWKGQIEKDLPRTFPGH--------PALDD 326
Query: 326 LIIKSLRRILKAFAIYNAKIGYCQSMNFLVGLLLLFMDEERAFWMLVIMTSRYLPGVHSI 385
+LRR+L A+A +N +GYCQ+MNF LLLL M EE AFW L+ + Y G +S
Sbjct: 327 DGRNALRRLLTAYARHNPSVGYCQAMNFFAALLLLLMPEENAFWALIGLIDDYFNGYYSE 386
Query: 386 NLEGVNINQGVLLLCIKEYLPHFWQRIYSNKDQQHSPGLSNKNEFLYKLPPVTLCTASWF 445
+ ++Q VL ++E P ++ + D Y V T WF
Sbjct: 387 EMIESQVDQLVLEELVRERFP----KLVHHLD--------------YLGVQVAWVTGPWF 428
Query: 446 MSCFIGVVPIEATLRIWDCLFYEGSHI-LFKMSLAIIEL 483
+S F+ ++P E+ LR+WD L +EG+ + LF+ +LA++EL
Sbjct: 429 LSIFMNMLPWESVLRVWDVLLFEGTRVMLFRTALALMEL 467
>CE29155 [U] KOG2058 Ypt/Rab GTPase activating protein
Length = 908
Score = 113 bits (282), Expect = 1e-24
Identities = 82/256 (32%), Positives = 122/256 (47%), Gaps = 38/256 (14%)
Query: 244 SEKLKRYVRKGIPAEWRGNAW------WYFARGQELLNKNIGVYDKLL----TKINDPSF 293
S LK +R G+P +RG W W + EL N G Y +L TK D S+
Sbjct: 620 SPDLKTLIRTGVPPAYRGRVWKIIVTHWVKDKQAELGN---GYYQSMLRKAGTKKQDGSY 676
Query: 294 TSKDTEIIERDLHRTFPDNIHFQRSKVSSEDPLIIKSLRRILKAFAIYNAKIGYCQSMNF 353
+ +I + DL RT P N F D I+ LR +L AF +N+ +GYCQ +N
Sbjct: 677 DAAIKQI-DLDLARTLPTNKLFDEP-----DSANIEKLRNVLYAFRYHNSHVGYCQGLNR 730
Query: 354 LVGLLLLFMDEERAFWMLVIMTSRYLP-GVHSINLEGVNINQGVLLLCIKEYLPHFWQRI 412
L + LL +DE+ +FW LV P G ++ +L G +Q VL + E LP
Sbjct: 731 LAAIALLNLDEQDSFWFLVACVEHLQPEGYYTSSLIGAVADQKVLRDLVAEKLP------ 784
Query: 413 YSNKDQQHSPGLSNKNEFLYKLPPVTLCTASWFMSCFIGVVPIEATLRIWDCLFYEGSHI 472
K H L ++L SWF++CF+ V+P L I+D YEG+ +
Sbjct: 785 ---KLAAHLRALE---------VDLSLFALSWFLTCFVDVLPHSIYLTIFDAFLYEGNKV 832
Query: 473 LFKMSLAIIELSETNL 488
LF+ +LA+ ++ E ++
Sbjct: 833 LFRFALALFKICEPHV 848
>CE28983 [R] KOG1102 Rab6 GTPase activator GAPCenA and related TBC domain
proteins
Length = 1005
Score = 107 bits (267), Expect = 5e-23
Identities = 70/252 (27%), Positives = 123/252 (48%), Gaps = 30/252 (11%)
Query: 244 SEKLKRYVRKGIPAEWRGNAWWYFARGQELLNKNIGVYDKLLTKINDPSFTSKDTEIIER 303
S+K++ + KGIP + R W + L ++ VY +LL + SKD + I+
Sbjct: 502 SKKMEDRIWKGIPEKLRIVIWPRLLGAERLKHERRDVYAELLLRAR---LVSKDIKQIDL 558
Query: 304 DLHRTFPDNIHFQRSKVSSEDPLIIKSLRRILKAFAIYNAKIGYCQSMNFLVGLLLLFMD 363
D++RT+ D++ F++ + KSL +L A++++N ++GYCQ M+ + L L+++D
Sbjct: 559 DINRTYRDHLAFRKRYDVKQ-----KSLLNVLAAYSMFNTEVGYCQGMSQIAALFLMYLD 613
Query: 364 EERAFW---MLVIMTSRYLPGVHSINLEGVNINQGVLLLCIKEYLPHFWQRIYSNKDQQH 420
EE AFW L++ + G + + +K+Y P R+Y + ++Q
Sbjct: 614 EEDAFWSLHQLMVSPKHTMHGFFVPGFPKLQRYEEHFKRVLKKYKP----RVYKHLEKQD 669
Query: 421 SPGLSNKNEFLYKLPPVTLCTASWFMSCFIGVVPIEATLRIWDCLFYEGSHILFKMSLAI 480
P ++Y W+ CF+ VP LR+WD EG IL M+ I
Sbjct: 670 IP-------YIY--------LTKWWFGCFLDRVPFSLALRLWDVFLVEGDCILIAMAYNI 714
Query: 481 IELSETNLPKLN 492
+++ E N+ K N
Sbjct: 715 MKMHEKNVRKHN 726
>CE17203 [U] KOG2221 PDZ-domain interacting protein EPI64 contains TBC
domain
Length = 458
Score = 104 bits (260), Expect = 3e-22
Identities = 85/306 (27%), Positives = 135/306 (43%), Gaps = 40/306 (13%)
Query: 243 KSEKLKRYVRKGIPAEWRGNAWWYF--ARGQELLNKNIGVYDKLLTKINDPSFTSKDTEI 300
K E +K RKGIP RG AW Y A Q ++ N V+D + + DP +
Sbjct: 176 KFELVKNRCRKGIPPSLRGRAWKYLSGATYQMEVSSNRFVFDYCVKQAGDPKWNDD---- 231
Query: 301 IERDLHRTFPDNIHFQR-SKVSSEDPLIIKSLRRILKAFAIYNAKIGYCQSMNFLVGLLL 359
I++DL R FP++ F R K + L +LKA+ I + + GYCQ + +LL
Sbjct: 232 IQKDLSRQFPEHEMFARVGKYGNNGK---NDLFDLLKAWTILHPEEGYCQGQAPIAAVLL 288
Query: 360 LFMDEERAFWMLVIMTSRYLPGVHSINLEGVNINQGVLLLCIKEYLPHFWQRIYSNKDQQ 419
+ M AF+ V + +YLPG +S LE V + +L IK+ ++ +N
Sbjct: 289 MHMPVRDAFYCFVQICHKYLPGYYSSGLEAVQTDGDILTKLIKDRSKLTYRHFKAN---- 344
Query: 420 HSPGLSNKNEFLYKLPPVTLCTASWFMSCFIGVVPIEATLRIWDCLFYEGSHILFKMSLA 479
+ LY + WFM CF +P LR+WD EG ILFK++L
Sbjct: 345 ------GVDPALYMI--------EWFMCCFCRTLPWPTVLRVWDMFLCEGVKILFKVALV 390
Query: 480 IIELSETNLPKLNHVSSRNSDDEDMELFQAIQTYPRRLINPNDIIDKAIFKRRLRFNALN 539
+++ ++ AI T R L P +I+++ +++ LN
Sbjct: 391 LLKFGIGTPSQIKQYPD----------MPAIVTRLRNL--PVEIMEEEFLVQKISETNLN 438
Query: 540 QEEIER 545
++E+
Sbjct: 439 DADMEK 444
>Hs18590199 [R] KOG4436 Predicted GTPase activator NB4S/EVI5 (contains TBC
domain)/Calmodulin-binding protein Pollux (contains PTB
and TBC domains)
Length = 794
Score = 102 bits (254), Expect = 2e-21
Identities = 86/331 (25%), Positives = 158/331 (46%), Gaps = 49/331 (14%)
Query: 243 KSEKLKRYVRKGIPAEWRGNAWWYFARGQELLNKNIGVYDKLLTKINDPSFTSKDTEIIE 302
K + LK +RKGIP +R W ++ KN Y +LL K++ P ++I
Sbjct: 104 KEKLLKELIRKGIPHHFRAIVWQLLCSATDMPVKN--QYSELL-KMSSPC-----EKLIR 155
Query: 303 RDLHRTFPDNIHFQRSKVSSEDPLIIKSLRRILKAFAIYNAKIGYCQSMNFLVGLLLLFM 362
RD+ RT+P++ F+ +D L + L ++KA+++ + ++GYCQ F+VGLLL+ M
Sbjct: 156 RDIARTYPEHEFFK-----GQDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQM 210
Query: 363 DEERAFWMLVIMTSRYLPGVHSINLEGVNINQGVLLLCIKEYLPHFWQRIYSNKDQQHSP 422
EE AF + V + Y E + L LCI + + Q+ P
Sbjct: 211 PEEEAFCVFVRLMQEYR------LRELFKPSMAELGLCIYQ---------FEYMLQEQLP 255
Query: 423 GLSNKNEFLYKLPPVTLCTASWFMSCFIGVVPIEATLRIWDCLFYEGSHILFKMSLAIIE 482
L+ F + ++ +SWF++ F+ P+ R++D YEG I+F++ LA+++
Sbjct: 256 DLN--THFRSQSFHTSMYASSWFLTLFLTTFPLPVATRVFDIFMYEGLEIVFRVGLALLQ 313
Query: 483 LSETNLPKLNHVSSRNSDDEDMELFQAIQTYPRRLI--NPNDIIDKAIFKR-RLRFNALN 539
+++ L +L DME + Y +R+I + DK + K ++++N
Sbjct: 314 VNQAELMQL-----------DME---GMSQYFQRVIPHQFDSCPDKLVLKAYQVKYNPKK 359
Query: 540 QEEIERCKKYVISQRAKYKNFQDVMKNETTN 570
+ +E K+Y + + + ++ + T N
Sbjct: 360 MKRLE--KEYAAMKSKEMEEQIEIKRLRTEN 388
>SPCC1259.11c [R] KOG4347 GTPase-activating protein VRP
Length = 720
Score = 100 bits (249), Expect = 7e-21
Identities = 66/242 (27%), Positives = 120/242 (49%), Gaps = 27/242 (11%)
Query: 243 KSEKLKRYVRKGIPAEWRGNAWWYFARGQELLNKNIGVYDKLLTKINDPSFTSKDTEIIE 302
++ ++ V+ GIP R + W + K+ G Y K + + + + +E IE
Sbjct: 205 QTPNFQKLVQSGIPNNLRADIWETCSGSLFPRWKSKGFYAKNIDSVINNR--CEYSEEIE 262
Query: 303 RDLHRTFPDNIHFQRSKVSSEDPLIIKSLRRILKAFAIYNAKIGYCQSMNFLVGLLLLFM 362
+DL R+ PD +Q P I +LRRIL ++ N ++GYCQ+MN ++ LL++
Sbjct: 263 KDLTRSLPDYPAYQ-------SPTGINTLRRILLFYSETNKEVGYCQAMNIVLAALLVYC 315
Query: 363 DEERAFWMLVIMTSRYLPGVHSINLEGVNINQGVLLLCIKEYLPHFWQRIYSNKDQQHSP 422
EE+A+++ + Y+PG ++ + G+ ++ V ++ LPH +Q+I
Sbjct: 316 TEEQAYFLFSQLCEFYIPGYYAKIIHGLLLDLTVFEYVLEHTLPHLYQKIIELD------ 369
Query: 423 GLSNKNEFLYKLPPVTLCTASWFMSCFIGVVPIEATLRIWDCLFYEGSHILFKMSLAIIE 482
+ L T +WF S FI ++ RI DCLF G +LF+++LA+ +
Sbjct: 370 ------------MDLKLITINWFFSLFIKDFRLDYAFRILDCLFVNGPRVLFQVALALFK 417
Query: 483 LS 484
++
Sbjct: 418 VN 419
>SPBC215.01 [R] KOG4347 GTPase-activating protein VRP
Length = 827
Score = 100 bits (248), Expect = 9e-21
Identities = 68/242 (28%), Positives = 117/242 (48%), Gaps = 27/242 (11%)
Query: 249 RYVRKGIPAEWRGNAWWYFARGQELLNKNIGVYDKLLTKINDPSFTSKDTEIIERDLHRT 308
+ VR +P + RG W + +N YD LL + TS E IE+DL R+
Sbjct: 215 KLVRIELPNKLRGEIWELTSGSMYFRLENSDEYDHLLKVYSGQ--TSFSLEEIEKDLGRS 272
Query: 309 FPDNIHFQRSKVSSEDPLIIKSLRRILKAFAIYNAKIGYCQSMNFLVGLLLLFMDEERAF 368
P+ +Q + I +LR +L AF+ N ++GYCQ+MN + LL+ EE+ F
Sbjct: 273 LPEYPAYQNEEG-------INALRNVLVAFSWKNQEVGYCQAMNIVAAALLIHCTEEQTF 325
Query: 369 WMLVIMTSRYLPGVHSINLEGVNINQGVLLLCIKEYLPHFWQRIYSNKDQQHSPGLSNKN 428
+++ + Y+PG +S + G I+ Q++Y + Q+ P L
Sbjct: 326 FLMHKICEDYIPGYYSKTMYGTLID----------------QQVYESLVQRSMPNL--HA 367
Query: 429 EFLYKLPPVTLCTASWFMSCFIGVVPIEATLRIWDCLFYEGSHILFKMSLAIIELSETNL 488
F+ K +++ + WF+S F+ +P+ R+ D F EG +LF++ +AI+ +E +
Sbjct: 368 HFVSKDIQLSIISLPWFLSLFLCTMPLPYAFRLLDFFFLEGPRVLFQIGMAILYDNEAEI 427
Query: 489 PK 490
K
Sbjct: 428 MK 429
>Hs19923325_1 [R] KOG4436 Predicted GTPase activator NB4S/EVI5 (contains TBC
domain)/Calmodulin-binding protein Pollux (contains PTB
and TBC domains)
Length = 707
Score = 99.4 bits (246), Expect = 1e-20
Identities = 67/251 (26%), Positives = 122/251 (47%), Gaps = 32/251 (12%)
Query: 243 KSEKLKRYVRKGIPAEWRGNAWWYFARGQELLNKNIGVYDKLLTKINDPSFTSKDTEIIE 302
K +++K V KGIP +R W Q + K+ Y +LL TS ++I
Sbjct: 152 KEKQVKELVHKGIPHHFRAIVWQLLCSAQSMPIKD--QYSELL------KMTSPCEKLIR 203
Query: 303 RDLHRTFPDNIHFQRSKVSSEDPLIIKSLRRILKAFAIYNAKIGYCQSMNFLVGLLLLFM 362
RD+ RT+P++ F+ +D L + L ++KA+++ + ++GYCQ F+VGLLL+ M
Sbjct: 204 RDIARTYPEHNFFKE-----KDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQM 258
Query: 363 DEERAFWMLVIMTSRY-LPGVHSINLEGVNINQGVLLLCIKEYLPHFWQRIYSNKDQQHS 421
EE AF + V + Y L + ++ + + I+E+LP + S
Sbjct: 259 PEEEAFCVFVKLMQDYRLRELFKPSMAELGLCMYQFECMIQEHLPELFVHFQSQSFH--- 315
Query: 422 PGLSNKNEFLYKLPPVTLCTASWFMSCFIGVVPIEATLRIWDCLFYEGSHILFKMSLAII 481
++ +SWF++ F+ P+ RI+D EG I+F++ LA++
Sbjct: 316 ---------------TSMYASSWFLTIFLTTFPLPVATRIFDIFMSEGLEIVFRVGLALL 360
Query: 482 ELSETNLPKLN 492
++++ L +L+
Sbjct: 361 QMNQAELMQLD 371
>CE10236 [TR] KOG2222 Uncharacterized conserved protein contains TBC SH3 and
RUN domains
Length = 808
Score = 98.6 bits (244), Expect = 2e-20
Identities = 81/298 (27%), Positives = 139/298 (46%), Gaps = 42/298 (14%)
Query: 301 IERDLHRTFPDNIHFQRSKVSSEDPLIIKSLRRILKAFAIYNAKIGYCQSMNFLVGLLLL 360
IERDL RT P+NI F K +SE I++LRRILK A +GYCQ M +V LLL
Sbjct: 195 IERDLLRTLPNNICFW--KKNSEG---IEALRRILKCVAFIYPDLGYCQGMGVIVATLLL 249
Query: 361 FMDEERAFWMLVIMTSRYL-PGVHSINLEGVNINQGVLLLCIKEYLPHFWQRIYSNKDQQ 419
+ EE FWM+ + L P ++ L G+ ++ V +K ++P
Sbjct: 250 YCSEETTFWMMTALIEDILPPNFYTQTLLGLQADERVSRHLMKCHVPDL----------- 298
Query: 420 HSPGLSNKNEFLYKLPPVTLCTASWFMSCFIGVVPIEATLRIWDCLFYEGSHILFKMSLA 479
NK Y++ V+L T SW ++ F V LR+WD +FY G +F++ ++
Sbjct: 299 ------NKALEDYEV-EVSLLTVSWLLTLFGSVFRTRVMLRVWDFIFYSGGVNIFRVIIS 351
Query: 480 IIELSETNLPKLNHVSSRNSDDEDMELFQAIQTYPRRLINPNDIIDKAIFKRRLRFNALN 539
I+++ E + ++ + ++D +F A+ P + +I+ + F +
Sbjct: 352 ILKMKEQEIVEIAETTQSSAD-----IFTALSQLPASVTEVEKVIE---YMGSFEFTITD 403
Query: 540 QEEIERCKKYVISQRAKYKNFQDVMKNETTNSN------NKRDSKLAQELINETFSNE 591
E KK+ +A Q ++ N T++N +R ++ +I + FS++
Sbjct: 404 HLIAELRKKH----QAVLMADQGMIVNTATDTNLPKQTTQRRKLTRSKSIIKQIFSSK 457
>Hs12232373 [R] KOG1102 Rab6 GTPase activator GAPCenA and related TBC domain
proteins
Length = 997
Score = 97.4 bits (241), Expect = 6e-20
Identities = 72/247 (29%), Positives = 117/247 (47%), Gaps = 31/247 (12%)
Query: 243 KSEKLKRYVRKGIPAEWRGNAWWYFARGQELLNKNIGVYDKLLTKINDPSFTSKDTEIIE 302
+ ++L VR G+P RG W A G + + Y L+TK S I
Sbjct: 483 RPKQLSSLVRNGVPEALRGEVWQLLA-GCHNNDHLVEKYRILITK------ESPQDSAIT 535
Query: 303 RDLHRTFPDNIHFQRSKVSSEDPLIIKSLRRILKAFAIYNAKIGYCQSMNFLVGLLLLFM 362
RD++RTFP + +F+ + +D SL +I KA+++Y+ +IGYCQ +FL +LLL M
Sbjct: 536 RDINRTFPAHDYFKDTGGDGQD-----SLYKICKAYSVYDEEIGYCQGQSFLAAVLLLHM 590
Query: 363 DEERAFWMLV-IMTSRYLPGVHSINLEGVNINQGVLLLCIKEYLPHFWQRIYSNKDQQHS 421
EE+AF +LV IM L + N E ++ L ++EY+P +
Sbjct: 591 PEEQAFSVLVKIMFDYGLRELFKQNFEDLHCKFYQLERLMQEYIPDLY------------ 638
Query: 422 PGLSNKNEFLYKLPPVTLCTASWFMSCFIGVVPIEATLRIWDCLFYEGSHILFKMSLAII 481
N FL + + WF++ F P+ I D L EG ++F ++L ++
Sbjct: 639 ------NHFLDISLEAHMYASQWFLTLFTAKFPLYMVFHIIDLLLCEGISVIFNVALGLL 692
Query: 482 ELSETNL 488
+ S+ +L
Sbjct: 693 KTSKDDL 699
>CE27154 [R] KOG1102 Rab6 GTPase activator GAPCenA and related TBC domain
proteins
Length = 1140
Score = 96.7 bits (239), Expect = 9e-20
Identities = 63/251 (25%), Positives = 122/251 (48%), Gaps = 27/251 (10%)
Query: 243 KSEKLKRYVRKGIPAEWRGNAWWYFARGQELLNKNIGVYDKLLTKINDPSFTSKDTEIIE 302
+ +K+ V GIP + RG W + + L + +K ++ P ++I
Sbjct: 449 RPQKISELVLDGIPDKLRGRVWQLLSNVRILAIDQPDLVEKYHIFLSQPC---PSEQVIM 505
Query: 303 RDLHRTFPDNIHFQRSKVSSEDPLIIKSLRRILKAFAIYNAKIGYCQSMNFLVGLLLLFM 362
RD+HRTFP + +F+ S+ + +SL +I K +++Y+ ++ YCQ ++FL LLL M
Sbjct: 506 RDIHRTFPAHDYFKESQGKGQ-----QSLYKISKVYSLYDEEVSYCQGLSFLAASLLLHM 560
Query: 363 DEERAFWMLV-IMTSRYLPGVHSINLEGVNINQGVLLLCIKEYLPHFWQRIYSNKDQQHS 421
EE+AF LV IM + L + + + +++ L +K+Y+P + + H
Sbjct: 561 PEEQAFCTLVKIMFNYGLRDLFKLGFDNLHLRFFQLTALLKDYIPDLSHHLEHIGIETH- 619
Query: 422 PGLSNKNEFLYKLPPVTLCTASWFMSCFIGVVPIEATLRIWDCLFYEGSHILFKMSLAII 481
+ + WF++ F P++ I D +G + +F +SLA++
Sbjct: 620 -----------------MYASQWFLTLFTAKFPLQMVFFILDLFLSQGMNTIFHISLALL 662
Query: 482 ELSETNLPKLN 492
+ ++T+L +L+
Sbjct: 663 DDAKTDLLQLD 673
>CE27153 [R] KOG1102 Rab6 GTPase activator GAPCenA and related TBC domain
proteins
Length = 1136
Score = 94.0 bits (232), Expect = 6e-19
Identities = 65/251 (25%), Positives = 121/251 (47%), Gaps = 31/251 (12%)
Query: 243 KSEKLKRYVRKGIPAEWRGNAWWYFARGQELLNKNIGVYDKLLTKINDPSFTSKDTEIIE 302
+ +K+ V GIP + RG W +LL+ I D + S ++I
Sbjct: 449 RPQKISELVLDGIPDKLRGRVW-------QLLSNAIDQPDLVEKYHIFLSQPCPSEQVIM 501
Query: 303 RDLHRTFPDNIHFQRSKVSSEDPLIIKSLRRILKAFAIYNAKIGYCQSMNFLVGLLLLFM 362
RD+HRTFP + +F+ S+ + +SL +I K +++Y+ ++ YCQ ++FL LLL M
Sbjct: 502 RDIHRTFPAHDYFKESQGKGQ-----QSLYKISKVYSLYDEEVSYCQGLSFLAASLLLHM 556
Query: 363 DEERAFWMLV-IMTSRYLPGVHSINLEGVNINQGVLLLCIKEYLPHFWQRIYSNKDQQHS 421
EE+AF LV IM + L + + + +++ L +K+Y+P + + H
Sbjct: 557 PEEQAFCTLVKIMFNYGLRDLFKLGFDNLHLRFFQLTALLKDYIPDLSHHLEHIGIETH- 615
Query: 422 PGLSNKNEFLYKLPPVTLCTASWFMSCFIGVVPIEATLRIWDCLFYEGSHILFKMSLAII 481
+ + WF++ F P++ I D +G + +F +SLA++
Sbjct: 616 -----------------MYASQWFLTLFTAKFPLQMVFFILDLFLSQGMNTIFHISLALL 658
Query: 482 ELSETNLPKLN 492
+ ++T+L +L+
Sbjct: 659 DDAKTDLLQLD 669
>Hs18580214 [U] KOG2058 Ypt/Rab GTPase activating protein
Length = 761
Score = 92.0 bits (227), Expect = 2e-18
Identities = 66/234 (28%), Positives = 117/234 (49%), Gaps = 21/234 (8%)
Query: 254 GIPAEWRGNAWWYFARGQELLNKNIGVYDKLL----TKINDPSFTSKDTEIIERDLHRTF 309
GIP EWR W A L+ +DK + + ++P S +I+ +DLHRT
Sbjct: 86 GIPKEWRRKVWLTLA--DHYLHSIAIDWDKTMRFTFNERSNPDDDSMGIQIV-KDLHRTG 142
Query: 310 PDNIHFQRSKVSSEDPLIIKSLRRILKAFAIYNAKIGYCQSMNFLVGLLLLFMD--EERA 367
+ Q ++ +D +++K R+L A+A +N +GYCQ N L L+L M+ E A
Sbjct: 143 CSSYCGQEAE---QDRVVLK---RVLLAYARWNKTVGYCQGFNILAALILEVMEGNEGDA 196
Query: 368 FWMLVIMTSRYLPGVHSIN-LEGVNINQGVLLLCIKEYLPHFWQRIYSNKDQQHSPGLSN 426
+++ + + LP + +N L ++++ V ++ LP Q + + + +
Sbjct: 197 LKIMIYLIDKVLPESYFVNNLRALSVDMAVFRDLLRMKLPELSQHLDTLQRTANKESGGG 256
Query: 427 KNEFLYKLPPVTLCTASWFMSCFIGVVPIEATLRIWDCLFYEGSHILFKMSLAI 480
Y+ P + T WF++ F +P + L+IWD +F+EGS I+ ++SLAI
Sbjct: 257 -----YEPPLTNVFTMQWFLTLFATCLPNQTVLKIWDSVFFEGSEIILRVSLAI 305
>CE07531 [R] KOG4436 Predicted GTPase activator NB4S/EVI5 (contains TBC
domain)/Calmodulin-binding protein Pollux (contains PTB
and TBC domains)
Length = 480
Score = 91.3 bits (225), Expect = 4e-18
Identities = 78/312 (25%), Positives = 141/312 (45%), Gaps = 49/312 (15%)
Query: 247 LKRYVRKGIPAEWRGNAWWYFARGQELLNKNIG-VYDKLLTKINDPSFTSKDTEIIERDL 305
+K V++GIP +R AW Q L N ++ V+D + S K +I+RD+
Sbjct: 148 IKDLVKRGIPQHFRMIAW------QNLSNASVSSVHDLYSDYMRQSSVYEK---VIQRDI 198
Query: 306 HRTFPDNIHFQRSKVSSEDPLIIKSLRRILKAFAIYNAKIGYCQSMNFLVGLLLLFMDEE 365
RT+P+ F+ + L ++KA+++++ ++GYCQ F+VGLLLL M EE
Sbjct: 199 PRTYPELDFFKDGERGQS------LLFNVIKAYSVHDKEVGYCQGSAFIVGLLLLQMPEE 252
Query: 366 RAFWMLVIMTSRY-LPGVHSINLEGVNINQGVLLLCIKEYLPHFWQRIYSNKDQQHSPGL 424
AF +LV + Y L ++ + + + L +++ +P +
Sbjct: 253 EAFAVLVSLMENYRLRELYKPTMTDLGLCMFQLECLVQDQMPDLYTHF------------ 300
Query: 425 SNKNEFLYKLPPVTLCTASWFMSCFIGVVPIEATLRIWDCLFYEGSHILFKMSLAIIELS 484
N F ++ +SWF++ F +P++ RI DC EG +F +S+AI++ +
Sbjct: 301 -NNMGF-----DTSMYASSWFLTLFTTTMPLDIANRIMDCFLVEGMDFIFCISIAILQQA 354
Query: 485 ETNLPKLNHVSSRNSDDEDMELFQAIQTYPRRLINPNDIIDKAIFKRRLRFNALNQEEIE 544
L +L DME + Y +R + D + LN + ++
Sbjct: 355 RIELLRL-----------DME---GMLKYFQREVRERYEFDADLLFTVANQVQLNAKRMK 400
Query: 545 RCKKYVISQRAK 556
R +K +++R K
Sbjct: 401 RLEKDYLTKRTK 412
>Hs20532509 [R] KOG4436 Predicted GTPase activator NB4S/EVI5 (contains TBC
domain)/Calmodulin-binding protein Pollux (contains PTB
and TBC domains)
Length = 937
Score = 90.1 bits (222), Expect = 9e-18
Identities = 77/309 (24%), Positives = 141/309 (44%), Gaps = 68/309 (22%)
Query: 238 SRFPSKSEKLKRYVRKGIPAEWRGNAWWYFARGQELLN--------KNIGVYDKLLTKIN 289
S+ EK+ V +G+P RG W + A L + K++ Y +LL ++
Sbjct: 553 SKIKFDMEKMHSAVGQGVPRHHRGEIWKFLAEQFHLKHQFPSKQQPKDVP-YKELLKQL- 610
Query: 290 DPSFTSKDTEIIERDLHRTFPDNIHFQRSKVSSEDPLIIKSLRRILKAFAIYNAKIGYCQ 349
TS+ I+ DL RTFP + +F + + SL ILKA+++ + ++GYCQ
Sbjct: 611 ----TSQQHAILI-DLGRTFPTHPYFSAQLGAGQ-----LSLYNILKAYSLLDQEVGYCQ 660
Query: 350 SMNFLVGLLLLFMDEERAFWMLVI------MTSRYLPGVHSINLEGVNINQGVLLLCIKE 403
++F+ G+LLL M EE AF ML + +Y P + + ++ +++
Sbjct: 661 GLSFVAGILLLHMSEEEAFKMLKFLMFDMGLRKQYRPDMIILQIQMYQLSR--------- 711
Query: 404 YLPHFWQRIYSNKDQQHSPGLSNKNEFLYKLPPVTLCTASWFMSCFIGVVPIEATLRIWD 463
L H + R N ++H G S L A WF++ F P+ R++D
Sbjct: 712 -LLHDYHRDLYNHLEEHEIGPS-------------LYAAPWFLTMFASQFPLGFVARVFD 757
Query: 464 CLFYEGSHILFKMSLA-----------------IIELSETNLPKLNHVSSRNSDDE--DM 504
+F +G+ ++FK++L+ I++ ++ LP L V + ++ +M
Sbjct: 758 MIFLQGTEVIFKVALSLLGSHKPLILQHENLETIVDFIKSTLPNLGLVQMEKTINQVFEM 817
Query: 505 ELFQAIQTY 513
++ + +Q Y
Sbjct: 818 DIAKQLQAY 826
>7292646 [R] KOG4436 Predicted GTPase activator NB4S/EVI5 (contains TBC
domain)/Calmodulin-binding protein Pollux (contains PTB
and TBC domains)
Length = 803
Score = 90.1 bits (222), Expect = 9e-18
Identities = 82/365 (22%), Positives = 146/365 (39%), Gaps = 72/365 (19%)
Query: 129 TLATEDKTINLDDSGSSDALNGIGQLPTPESESRASQLLGNSSLIEDAASIKV------- 181
T ++ + +D G AL G LPT E + A N + DA S+
Sbjct: 8 TASSAESQAKMDVKGG--ALPGEENLPTSEMDLLAKLEAANKLIESDAKSLNSLHSTHSR 65
Query: 182 KDSHLDRYGFMKQNQYISEKQYNEWWSEYSKYCIXXXXXXXXXXXXSGLPVDNDSPSRFP 241
K+S + ++E+ W+ + ND
Sbjct: 66 KNSDTSQISLTSSGNSVAEEDIWTTWAT----------------------ILNDWEGALK 103
Query: 242 SKSEKLKRYVRKGIPAEWRGNAWWYFARGQELLNKNIGVYDKLLTKINDPSFTSKDTEII 301
K+ + VR+GIP +R W + + K Y K TS ++I
Sbjct: 104 RKNPCVSELVRRGIPHHFRAIVWQQLSGASDGDKKQYAEYIKA---------TSACEKVI 154
Query: 302 ERDLHRTFPDNIHFQRSKVSSEDPLIIKSLRRILKAFAIYNAKIGYCQSMNFLVGLLLLF 361
RD+ RT+P+ F+ ++ L ++KA+++++ ++GYCQ F+VGLLL+
Sbjct: 155 RRDIARTYPEVEFFKEKDGPGQEALF-----NVIKAYSLHDREVGYCQGSGFIVGLLLMQ 209
Query: 362 MDEERAFWMLV-IMTSRYLPGVHSINLEGVNINQGVLLLCIKEYLP----HFWQRIYSNK 416
M EE AF +LV IM + + ++ + + L ++E +P HF Q+ +
Sbjct: 210 MPEEEAFAVLVQIMQQHRMRHMFKPSMSELGLCMYQLENLVQEQIPDMHIHFQQQGFQ-- 267
Query: 417 DQQHSPGLSNKNEFLYKLPPVTLCTASWFMSCFIGVVPIEATLRIWDCLFYEGSHILFKM 476
T+ +SWF++ + + + + RI D EG +FK+
Sbjct: 268 --------------------TTMYASSWFLTLYTTTLNVNLSCRIMDVFLSEGMEFIFKV 307
Query: 477 SLAII 481
+LA++
Sbjct: 308 ALALL 312
>SPAC4G8.04 [U] KOG2058 Ypt/Rab GTPase activating protein
Length = 772
Score = 89.4 bits (220), Expect = 2e-17
Identities = 77/255 (30%), Positives = 125/255 (48%), Gaps = 34/255 (13%)
Query: 246 KLKRYVRKGIPAEWRGNAWWYFARGQELLNKNIGVYDKLLTKINDPSFTSKDTEIIERDL 305
K + V+ G+P ++ W + +L + G Y++LL++ ++ S I+ D+
Sbjct: 496 KFRELVKNGVPLCYKAKVWLECSGAYQLHSP--GYYEELLSRTDEVE--SASVAQIDMDI 551
Query: 306 HRTFPDNIHFQRSKVSSEDPLIIKSLRRILKAFAIYNAKIGYCQSMNFL-VGLLLLFMDE 364
+RT N+ F + P I K LRRIL A++ +N IGYCQ MN + LLLL+ E
Sbjct: 552 NRTMAKNVFF-----GGKGPGIPK-LRRILVAYSRHNPHIGYCQGMNVIGAFLLLLYASE 605
Query: 365 ERAFWMLVIMTSRYLPGVH-SINLEGVNINQGVLLLCIKEYLPHFWQRIYSNKDQQHSPG 423
E AF+ML+ + LP + + +L +Q VL +KE LP IYS+
Sbjct: 606 EDAFYMLMSIIENVLPPKYFTPDLMTSRADQLVLKSFVKESLP----EIYSH-------- 653
Query: 424 LSNKNEFLYKLPPVTLCTAS--WFMSCFIGVVPIEATLRIWDCLFYEGSHILFKMSLAII 481
+L V L S WF+S + +P + RI+D LF +G LF+++L I+
Sbjct: 654 --------LELLGVDLDAISFHWFLSVYTDTLPTNISFRIFDMLFCDGYVCLFRVALTIL 705
Query: 482 ELSETNLPKLNHVSS 496
+ + + N S+
Sbjct: 706 KSLKQQILACNSSSA 720
>7295111 [R] KOG1102 Rab6 GTPase activator GAPCenA and related TBC domain
proteins
Length = 1194
Score = 89.4 bits (220), Expect = 2e-17
Identities = 63/251 (25%), Positives = 118/251 (46%), Gaps = 31/251 (12%)
Query: 243 KSEKLKRYVRKGIPAEWRGNAWWYFARGQELLNKNIGVYDKLLTKINDPSFTSKDTEIIE 302
+ + L VR G+P R W A + + N Y L+TK +K +I+
Sbjct: 642 RPKNLAPLVRLGVPEALREKIWQKLANVEGRMEMN-DKYKILITK------ETKCETVIQ 694
Query: 303 RDLHRTFPDNIHFQRSKVSSEDPLIIKSLRRILKAFAIYNAKIGYCQSMNFLVGLLLLFM 362
RD+HRTFP + F+ S +D L ++ KA+A++++++GYCQ ++F+ LLL M
Sbjct: 695 RDIHRTFPAHKCFKEIGGSGQDALF-----KVSKAYAVHDSEVGYCQGLSFIAASLLLHM 749
Query: 363 DEERAFWMLVIMTSRY-LPGVHSINLEGVNINQGVLLLCIKEYLPHFWQRIYSNKDQQHS 421
EE AF +LV + Y L ++ E + + L IK+ LP + + + H
Sbjct: 750 PEEDAFCVLVALMYDYGLRDLYKAGFEVLYLRLYQLERLIKDQLPKLHEHFTACGIETH- 808
Query: 422 PGLSNKNEFLYKLPPVTLCTASWFMSCFIGVVPIEATLRIWDCLFYEGSHILFKMSLAII 481
+ + WF++ + P+ + D +G +LF++++ ++
Sbjct: 809 -----------------MYASQWFLTLYTARFPLCFVFHVLDVFLLDGLPVLFQVAVTLL 851
Query: 482 ELSETNLPKLN 492
+ E++L +L+
Sbjct: 852 SICESDLRQLD 862
>7296688 [R] KOG4436 Predicted GTPase activator NB4S/EVI5 (contains TBC
domain)/Calmodulin-binding protein Pollux (contains PTB
and TBC domains)
Length = 1379
Score = 87.4 bits (215), Expect = 6e-17
Identities = 67/251 (26%), Positives = 115/251 (45%), Gaps = 45/251 (17%)
Query: 251 VRKGIPAEWRGNAWWYFARGQELLNKNIGVYDKLLTKINDP-----SFTSKDTEIIERDL 305
+R G+P RG+ W + A + V K N P ++ I DL
Sbjct: 740 IRTGVPRSKRGDVWTFLAEQHSM--NTAPVDTKRFPNFNTPYHMLLKHLTEHQHAIFIDL 797
Query: 306 HRTFPDNIHFQRSKVSSEDPLIIK--SLRRILKAFAIYNAKIGYCQSMNFLVGLLLLFMD 363
RTFP++ ++ DPL + SL +LKA++I + ++GYCQ + F+ G+LLL D
Sbjct: 798 GRTFPNHQFYK-------DPLGLGQLSLFNLLKAYSILDPELGYCQGLGFICGVLLLHCD 850
Query: 364 EERAFWMLV------IMTSRYLPGVHSINLEGVNINQGVLLLCIKEYLPHFWQRIYSNKD 417
E +F +L M ++YLP + L+ +++ +K++LP + + N
Sbjct: 851 EANSFQLLKHLMFRRNMRTKYLPDMKKFQLQLYQLSR-----LVKDHLPDLYVWLDQN-- 903
Query: 418 QQHSPGLSNKNEFLYKLPPVTLCTASWFMSCFIGVVPIEATLRIWDCLFYEGSHILFKMS 477
SP TL A W ++ F P+ R++D LF E S ++FK +
Sbjct: 904 -DVSP---------------TLYAAPWILTVFSSQFPLGFVARVFDLLFLESSDVIFKFA 947
Query: 478 LAIIELSETNL 488
+A++ + + L
Sbjct: 948 IALLSVHKQQL 958
>YPL249c [R] KOG1102 Rab6 GTPase activator GAPCenA and related TBC domain
proteins
Length = 894
Score = 85.1 bits (209), Expect = 3e-16
Identities = 74/266 (27%), Positives = 126/266 (46%), Gaps = 48/266 (18%)
Query: 232 VDNDSPSRFPSKSEKLKRYVRKGIPAEWRGNAWWYFARGQELLNKNIGVYDKLLTKINDP 291
V ND + ++ E L+ +V GIP + RG W A + ++I Y+ LL
Sbjct: 429 VVNDYATVASNEPENLEAHVTNGIPPQIRGIIWQLMANSKSREMEDI--YETLL------ 480
Query: 292 SFTSKDTEI-----IERDLHRTFPDNIHFQRSKVSSEDPLIIKSLRRILKAFAIYNAKIG 346
DTE I RDL RT K +ED + +SL +++K +++Y+ +G
Sbjct: 481 -----DTECLHEATIRRDLRRT----------KFVAEDKM--ESLYKVIKVYSVYDPDVG 523
Query: 347 YCQSMNFLVGLLLLFMDEE-RAFWMLVIMTSRYLPGVHSINLEGVNINQGVLLLCIKEYL 405
Y Q M F+ LL+ + E +F +LV + Y G+ + L G+ G++L+ +
Sbjct: 524 YTQGMGFIAAPLLINCENEAESFGLLVGLMKNY--GLRELFLPGM---PGLMLMLYQ--- 575
Query: 406 PHFWQRIYSNKDQQHSPGLSNKNEFLYKLPPVTLCTASWFMSCFIGVVPIEATLRIWDCL 465
+ ++HSP L N+ + + T+ WF++ F P+E LRI+D +
Sbjct: 576 -------FDRLLEEHSPSLYNR--LIREGISSTMYATQWFLTFFAYKFPLEFVLRIFDIV 626
Query: 466 FYEGSHILFKMSLAIIELSETNLPKL 491
F EG +L K ++ ++ +E L KL
Sbjct: 627 FVEGIEVLLKFAVNLMLKNEETLVKL 652
>Hs7662198 [R] KOG4436 Predicted GTPase activator NB4S/EVI5 (contains TBC
domain)/Calmodulin-binding protein Pollux (contains PTB
and TBC domains)
Length = 1299
Score = 82.4 bits (202), Expect = 2e-15
Identities = 64/258 (24%), Positives = 118/258 (44%), Gaps = 53/258 (20%)
Query: 245 EKLKRYVRKGIPAEWRGNAWWYFARGQELLNKNIGVYDKLLTKINDPSFTSKDT------ 298
E + +++G+P RG W + A L ++ L K P + K+
Sbjct: 910 EDIHTLLKEGVPKSRRGEIWQFLALQYRLRHR-------LPNKQQPPDISYKELLKQLTA 962
Query: 299 --EIIERDLHRTFPDNIHFQRSKVSSEDPLIIKSLRRILKAFAIYNAKIGYCQSMNFLVG 356
I DL RTFP + +F + SL +LKA+++ + ++GYCQ ++F+ G
Sbjct: 963 QQHAILVDLGRTFPTHPYFSVQLGPGQ-----LSLFNLLKAYSLLDKEVGYCQGISFVAG 1017
Query: 357 LLLLFMDEERAFWMLVIM------TSRYLPGVHSINLEGVNINQGVLLLCIKEYLPHFWQ 410
+LLL M EE+AF ML + +Y P + S+ ++ +++ L H +
Sbjct: 1018 VLLLHMSEEQAFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSR----------LLHDYH 1067
Query: 411 RIYSN--KDQQHSPGLSNKNEFLYKLPPVTLCTASWFMSCFIGVVPIEATLRIWDCLFYE 468
R N ++ + SP +L A WF++ F + R++D +F +
Sbjct: 1068 RDLYNHLEENEISP---------------SLYAAPWFLTLFASQFSLGFVARVFDIIFLQ 1112
Query: 469 GSHILFKMSLAIIELSET 486
G+ ++FK++L+++ ET
Sbjct: 1113 GTEVIFKVALSLLSSQET 1130
>Hs22058425 [U] KOG2058 Ypt/Rab GTPase activating protein
Length = 641
Score = 82.0 bits (201), Expect = 2e-15
Identities = 52/181 (28%), Positives = 95/181 (51%), Gaps = 14/181 (7%)
Query: 303 RDLHRTFPDNIHFQRSKVSSEDPLIIKSLRRILKAFAIYNAKIGYCQSMNFLVGLLLLFM 362
+DLHRT + Q ++ +D +++K R+L A+A +N +GYCQ N L L+L M
Sbjct: 341 KDLHRTGCSSYCGQEAE---QDRVVLK---RVLLAYARWNKTVGYCQGFNILAALILEVM 394
Query: 363 D--EERAFWMLVIMTSRYLPGVHSIN-LEGVNINQGVLLLCIKEYLPHFWQRIYSNKDQQ 419
+ E A +++ + + LP + +N L ++++ V ++ LP Q + + +
Sbjct: 395 EGNEGDALKIMIYLIDKVLPESYFVNNLRALSVDMAVFRDLLRMKLPELSQHLDTLQRTA 454
Query: 420 HSPGLSNKNEFLYKLPPVTLCTASWFMSCFIGVVPIEATLRIWDCLFYEGSHILFKMSLA 479
+ Y+ P + T WF++ F +P + L+IWD +F+EGS I+ ++SLA
Sbjct: 455 NKESGGG-----YEPPLTNVFTMQWFLTLFATCLPNQTVLKIWDSVFFEGSEIILRVSLA 509
Query: 480 I 480
I
Sbjct: 510 I 510
>At2g37290 [U] KOG2058 Ypt/Rab GTPase activating protein
Length = 544
Score = 81.6 bits (200), Expect = 3e-15
Identities = 74/271 (27%), Positives = 107/271 (39%), Gaps = 82/271 (30%)
Query: 236 SPSRFPSKSEKLKRYVRKGIPAEWRGNAWWYFARGQELLNKNIGVYDKLLTKINDPSFTS 295
SP F E+L+ VR G+P + RG W F + + Y LL +I + S
Sbjct: 169 SPEPFFPWYEELEVLVRLGVPKDLRGEVWQAFVGVKARRVERY--YQDLLAQITNSDENS 226
Query: 296 KDTEI-----IERDLHRTFPDNIHFQRSKVSSEDPLIIKSLRRILKAFAIYNAKIGYCQ- 349
D + IE+D+ RTFP + + S LRRIL A+A +N +GYCQ
Sbjct: 227 SDVQRKWKKQIEKDIPRTFPGHPALNENGRDS--------LRRILLAYACHNPSVGYCQV 278
Query: 350 ----------------SMNFLVGLLLLFMDEERAFWMLVIMTSRYLPGVHSINLEGVNIN 393
+MNF GLLLL M EE AFW LV + Y G ++ + ++
Sbjct: 279 TWARKSIFEYPIALIVAMNFFAGLLLLLMPEENAFWTLVGIIDDYFDGYYTEEMIESQVD 338
Query: 394 QGVLLLCIKEYLPHFWQRIYSNKDQQHSPGLSNKNEFLYKLPPVTLCTASWFMSCFIGVV 453
Q V ++E P
Sbjct: 339 QLVFEELMRERFP----------------------------------------------- 351
Query: 454 PIEATLRIWDCLFYEGSH-ILFKMSLAIIEL 483
+ LR+WD L +EG+ +LF+ + AI+EL
Sbjct: 352 --KLVLRMWDVLLFEGNRVVLFRTAFAIMEL 380
>7299317 [U] KOG2058 Ypt/Rab GTPase activating protein
Length = 3052
Score = 79.7 bits (195), Expect = 1e-14
Identities = 84/356 (23%), Positives = 147/356 (40%), Gaps = 52/356 (14%)
Query: 246 KLKRYVRKGIPAEWRGNAWWYFARGQELLNKNIGVYDKLLTKINDPSFTSKDTEI---IE 302
KL + G P E+R W A + L +KN+ + + K + D E+ I
Sbjct: 92 KLVARLPGGTPPEFRRKLWLSLA-DKYLKSKNVD-WAQQREKCFCEEWREDDEELGIQIV 149
Query: 303 RDLHRTFPDNIHFQRSKVSSEDPLIIKSLRRILKAFAIYNAKIGYCQ------------- 349
+DLHRT + ++ L+RIL +A YN ++GYCQ
Sbjct: 150 KDLHRTGSNLCTGPAGSINQA------KLKRILLGYARYNPEVGYCQVSAPSRIFVCCVH 203
Query: 350 ------SMNFLVGLLLLFMD--EERAFWMLVIMTSRYLP-GVHSINLEGVNINQGVLLLC 400
N L L+L MD EE + +++ + LP G ++ G+ + GV
Sbjct: 204 FTHIIQGFNMLGALILQVMDKEEEESMKVMIYLVEGVLPTGYFYGSMGGLQADMGVFREL 263
Query: 401 IKEYLPHFWQRIYSNKDQQHSPGLSNKNEFLYKLPPVTLCTASWFMSCFIGVVPIEATLR 460
++ LP +H L E ++ P + T WF++ F +P+ LR
Sbjct: 264 MQTRLPRL---------AKHLQRLQGPVENAFEPPLTNVFTMQWFLTMFCTCLPMSCVLR 314
Query: 461 IWDCLFYEGSHILFKMSLAIIELSETNLPKLNHVSSRNSDDEDMELFQAIQTYPRRLINP 520
+WD + EGS +L + +L + L E + +S R++D E + + +Y L+N
Sbjct: 315 VWDLVLIEGSDVLLRTALVLWSLLEERV-----ISVRSAD----EFYGKMGSYSSELLNG 365
Query: 521 NDIIDKAIFKRRLRFNALNQEEIERCKK-YVISQRAKYKNFQDVMKNETTNSNNKR 575
+ + + +R ++ + R K Y I+ + Q E T+S+ +R
Sbjct: 366 HLVDSNGLIERVVKLGPIEDLRQLRDKHLYNIAPLRHKQGLQLYYDEEDTHSDEER 421
>Hs4758564_1 [R] KOG1102 Rab6 GTPase activator GAPCenA and related TBC domain
proteins
Length = 498
Score = 78.6 bits (192), Expect = 3e-14
Identities = 69/254 (27%), Positives = 114/254 (44%), Gaps = 37/254 (14%)
Query: 244 SEKLKRYVRKGIPAEWRGNAWWYFARGQELLNKNIGVYDKLLTKINDPSFTSKDTEIIER 303
S KL V KGIP RG W QE+ KN G Y + + +S+ I+
Sbjct: 90 SSKLIDRVYKGIPMNIRGPVWSVLLNIQEIKLKNPGRYQIMKER---GKRSSEHIHHIDL 146
Query: 304 DLHRTFPDNIHFQRSKVSSEDPLIIKSLRRILKAFAIYNAKIGYCQSMNFLVGLLLLFMD 363
D+ T +++ F R + ++ + L IL A++ YN ++GYC+ ++ + L LL++
Sbjct: 147 DVRTTLRNHVFF-RDRYGAKQ----RELFYILLAYSEYNPEVGYCRDLSHITALFLLYLP 201
Query: 364 EERAFWMLV--IMTSRY-LPGVHSINLEGVNINQGVLLLCIKEYLPHFWQRIYSNKDQQH 420
EE AFW LV + + R+ LPG HS N V QG+ +DQQ
Sbjct: 202 EEDAFWALVQLLASERHSLPGFHSPNGGTV---QGL-------------------QDQQE 239
Query: 421 SPGLSNKNEFLYKLPPVTLCTASWFMSC----FIGVVPIEATLRIWDCLFYEGSHILFKM 476
++ + ++ LC + C I + + TLR+WD EG +L +
Sbjct: 240 HVVPKSQPKTMWHQDKEGLCGQCASLGCLLRNLIDGISLGLTLRLWDVYLVEGEQVLMPI 299
Query: 477 SLAIIELSETNLPK 490
+ +++ + L K
Sbjct: 300 TSIALKVQQKRLMK 313
>Hs22062568 [U] KOG2221 PDZ-domain interacting protein EPI64 contains TBC
domain
Length = 219
Score = 76.3 bits (186), Expect = 1e-13
Identities = 45/139 (32%), Positives = 67/139 (47%), Gaps = 9/139 (6%)
Query: 245 EKLKRYVRKGIPAEWRGNAWWYFARGQELLNKNIGVYDKLLTKINDPSFTSKDTEIIERD 304
+K+K RKGIP+ R W + G Y +L DP + E I RD
Sbjct: 83 KKVKMQCRKGIPSALRARCWPLLCGAHVCQKNSPGTYQELAEAPGDPQWM----ETIGRD 138
Query: 305 LHRTFPDNIHFQRSKVSSEDPLIIKSLRRILKAFAIYNAKIGYCQSMNFLVGLLLLFMDE 364
LHR FP + F + + L+ ++LKA+ +Y + GYCQ+ + +LL+ +
Sbjct: 139 LHRQFPLHEMFVSPQGHGQQGLL-----QVLKAYTLYRPEQGYCQAQGPVAAVLLMHLPP 193
Query: 365 ERAFWMLVIMTSRYLPGVH 383
E AFW LV + YLPG +
Sbjct: 194 EEAFWCLVQICEVYLPGYY 212
>CE28759 [TR] KOG2223 Uncharacterized conserved protein contains TBC domain
Length = 614
Score = 75.1 bits (183), Expect = 3e-13
Identities = 71/256 (27%), Positives = 106/256 (40%), Gaps = 34/256 (13%)
Query: 244 SEKLKRYVRKGIPAEWRGNAWWYFARGQELLNKNI--GVYDKLLTKI-------NDPSFT 294
S++ + +G+PA+ RG W+ Q + K + G+ D+ KI N S
Sbjct: 288 SKRCRELWWQGVPAKVRGELWFLTIGNQIEITKELYDGLMDQAEEKIAKQLAEQNKNSAE 347
Query: 295 SKDTEI--IERDLHRTFPDNIHFQRSKVSSEDPLIIKSLRRILKAFAIYNAKIGYCQSMN 352
K+T + I D RTF FQ+ D L ++L A+AI IGY QSM
Sbjct: 348 RKETSVTQIHLDATRTFTSLGMFQK------DGPYYDHLLKLLSAYAILRPDIGYVQSMT 401
Query: 353 FLVGLLLLFMDEERAFWMLVIMTSRYLPGVHSINLEGVNINQGVLLLCIKEYLPHFWQRI 412
F+ +LL+ MD AF + R L G+ + EY
Sbjct: 402 FIAAVLLIQMDPYPAFISFANLLDRSLQSAFF----------GLKQPQMTEYFI-----A 446
Query: 413 YSNKDQQHSPGLSNKNEFLYKLPPVTLCTASWFMSCFIGVVPIEATLRIWDCLFYEGSHI 472
Y +Q P L + L P + L W + + +P++ T RIWD F +G
Sbjct: 447 YDRYLEQELPALHQHLDKLDVRPDLYLI--EWTFAMYAKSLPLDVTCRIWDVYFRDGEEF 504
Query: 473 LFKMSLAIIELSETNL 488
LFK +L I+ + E L
Sbjct: 505 LFKAALGILRMYEPKL 520
>Hs14149985 [R] KOG1102 Rab6 GTPase activator GAPCenA and related TBC domain
proteins
Length = 549
Score = 74.7 bits (182), Expect = 4e-13
Identities = 68/254 (26%), Positives = 111/254 (42%), Gaps = 37/254 (14%)
Query: 244 SEKLKRYVRKGIPAEWRGNAWWYFARGQELLNKNIGVYDKLLTKINDPSFTSKDTEIIER 303
S KL KG+P RG W +E+ KN G Y + K +S+ + I+R
Sbjct: 91 SRKLIDRAYKGMPMNIRGPMWSVLLNTEEMKLKNPGRYQIMKEKGKK---SSEHIQRIDR 147
Query: 304 DLHRTFPDNIHFQRSKVSSEDPLIIKSLRRILKAFAIYNAKIGYCQSMNFLVGLLLLFMD 363
D+ T +I F R + ++ + L IL A+ YN ++GYC+ ++ + L LL++
Sbjct: 148 DVSGTLRKHIFF-RDRYGTKQ----RELLHILLAYEEYNPEVGYCRDLSHIAALFLLYLP 202
Query: 364 EERAFWMLV--IMTSRY-LPGVHSINLEGVNINQGVLLLCIKEYLPHFWQRIYSNKDQQH 420
EE AFW LV + + R+ L G HS N V QG+ +DQQ
Sbjct: 203 EEDAFWALVQLLASERHSLQGFHSPNGGTV---QGL-------------------QDQQE 240
Query: 421 SPGLSNKNEFLYKLPPVTLCTASWFMSCFIGV----VPIEATLRIWDCLFYEGSHILFKM 476
+++ + + LC + C I + + + TLR+WD EG L +
Sbjct: 241 HVVATSQPKTMGHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPI 300
Query: 477 SLAIIELSETNLPK 490
+ ++ + L K
Sbjct: 301 TRIAFKVQQKRLTK 314
>SPAC26F1.09 [R] KOG1102 Rab6 GTPase activator GAPCenA and related TBC domain
proteins
Length = 1031
Score = 73.9 bits (180), Expect = 7e-13
Identities = 54/201 (26%), Positives = 93/201 (45%), Gaps = 29/201 (14%)
Query: 301 IERDLHRTFPDNI--HF--QRSKVSSEDPLI--IKSLRRILKAFAIYNAKIGYCQSMNFL 354
I +DL RTF I HF R ++ D + +L R+L++ AI ++GY Q M+++
Sbjct: 649 IRKDLDRTFAPEILSHFFSNRQQLEPTDNIAESTANLHRVLRSLAIVLPQVGYTQGMSWI 708
Query: 355 VGLLLLFMDEERAFWMLVIMTSRY-LPGVHSINLEGVNINQGVLLLCIKEYLPHFWQRIY 413
G LL+ + +AF +LV + Y L + S + G++ +++Y+P
Sbjct: 709 AGALLMHLPAPQAFALLVFLFKNYHLQNIFSSEMRGLSRVLHQFTRLVEDYMPSL----- 763
Query: 414 SNKDQQHSPGLSNKNEFLYKLPPVTLCT--ASWFMSCFIGVVPIEATLRIWDCLFYEGSH 471
+K + C+ + WF++ F P+E ++D LF G
Sbjct: 764 ---------------AIHFKRQDIKTCSYASEWFLTLFAYKFPLEVVAHLYDILFLYGPG 808
Query: 472 ILFKMSLAIIELSETNLPKLN 492
ILF LA++ S+ +L KLN
Sbjct: 809 ILFNFGLALLSHSQESLLKLN 829
>Hs20560763 [R] KOG1102 Rab6 GTPase activator GAPCenA and related TBC domain
proteins
Length = 469
Score = 73.6 bits (179), Expect = 9e-13
Identities = 67/254 (26%), Positives = 111/254 (43%), Gaps = 37/254 (14%)
Query: 244 SEKLKRYVRKGIPAEWRGNAWWYFARGQELLNKNIGVYDKLLTKINDPSFTSKDTEIIER 303
S KL KG+P RG W +E+ KN G Y + K +S+ + I+R
Sbjct: 11 SRKLIDRAYKGMPMNIRGPMWSVLLNIEEMKLKNPGRYQIMKEK---GKRSSEHIQRIDR 67
Query: 304 DLHRTFPDNIHFQRSKVSSEDPLIIKSLRRILKAFAIYNAKIGYCQSMNFLVGLLLLFMD 363
D+ T ++ F R + ++ + L IL A+ YN ++GYC+ ++ + L LL+
Sbjct: 68 DISGTLRKHMFF-RDRYGTKQ----RELLHILLAYEEYNPEVGYCRDLSHIAALFLLYFP 122
Query: 364 EERAFWMLV--IMTSRY-LPGVHSINLEGVNINQGVLLLCIKEYLPHFWQRIYSNKDQQH 420
EE AFW LV + + R+ L G HS N V QG+ +DQQ
Sbjct: 123 EEDAFWALVQLLASERHSLQGFHSPNGGTV---QGL-------------------QDQQE 160
Query: 421 SPGLSNKNEFLYKLPPVTLCTASWFMSCFIGV----VPIEATLRIWDCLFYEGSHILFKM 476
+++++ + LC + C I + + + TLR+WD EG L +
Sbjct: 161 HVVATSQSKTMGHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPI 220
Query: 477 SLAIIELSETNLPK 490
+ ++ + L K
Sbjct: 221 TRIAFKVQQKRLTK 234
>Hs22066444 [R] KOG1102 Rab6 GTPase activator GAPCenA and related TBC domain
proteins
Length = 422
Score = 73.2 bits (178), Expect = 1e-12
Identities = 67/254 (26%), Positives = 111/254 (43%), Gaps = 37/254 (14%)
Query: 244 SEKLKRYVRKGIPAEWRGNAWWYFARGQELLNKNIGVYDKLLTKINDPSFTSKDTEIIER 303
S KL KG+P RG W +E+ KN G Y + K +S+ + I+R
Sbjct: 11 SRKLIDRAYKGMPMNIRGPMWSVLLNIEEMKLKNPGRYQIMKEK---GKRSSEHIQRIDR 67
Query: 304 DLHRTFPDNIHFQRSKVSSEDPLIIKSLRRILKAFAIYNAKIGYCQSMNFLVGLLLLFMD 363
D+ T ++ F R + ++ + L IL A+ YN ++GYC+ ++ + L LL++
Sbjct: 68 DISGTLRKHMFF-RDRYGTKQ----RELLHILLAYEEYNPEVGYCRDLSHIAALFLLYLP 122
Query: 364 EERAFWMLV--IMTSRY-LPGVHSINLEGVNINQGVLLLCIKEYLPHFWQRIYSNKDQQH 420
EE AFW LV + + R+ L G HS N V QG+ +DQQ
Sbjct: 123 EEDAFWALVQLLASERHSLQGFHSPNGGTV---QGL-------------------QDQQE 160
Query: 421 SPGLSNKNEFLYKLPPVTLCTASWFMSCFIGV----VPIEATLRIWDCLFYEGSHILFKM 476
+++ + + LC + C I + + + TLR+WD EG L +
Sbjct: 161 HVVATSQPKTMGHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPI 220
Query: 477 SLAIIELSETNLPK 490
+ ++ + L K
Sbjct: 221 TRIAFKVQQKRLTK 234
>SPBC1778.09 [R] KOG1102 Rab6 GTPase activator GAPCenA and related TBC domain
proteins
Length = 414
Score = 68.9 bits (167), Expect = 2e-11
Identities = 68/247 (27%), Positives = 106/247 (42%), Gaps = 38/247 (15%)
Query: 243 KSEKLKRYVRKGIPAEWRGNAWWYFARGQELLNKNIGVYDKLLTKINDPSFTSKDTEIIE 302
K+ KL KGIP WR AWW F K I Y +L +I D I+
Sbjct: 147 KTRKLILRTFKGIPDCWRSIAWWSFLVDSLPDKKLIDKYYQLNEQICDYDVQ------ID 200
Query: 303 RDLHRTFPDNIHFQRSKVSSEDPLIIKSLRRILKAFAIYNAKIGYCQSMNFLVGLLLLFM 362
D+ RT + F++ + + + L R+L A A+Y ++GY Q M + LL++
Sbjct: 201 LDVPRTAATHFLFRKRYIGGQ-----RLLFRVLHAVALYIPRVGYVQGMASIAATLLIYY 255
Query: 363 DEERAFWMLV-IMTSRYLPGVHSINLEGVNINQGVLLLCIKEYLPHFWQRIYSNKDQQHS 421
EE+AF M+V ++ +R + + S + LL + L H + + +H
Sbjct: 256 PEEQAFIMMVNLLENRGMGDLFSSGFD--------TLLKAFDMLKH---ELSFTQSGRHL 304
Query: 422 PGLSNKNEFLYKLPPVTLCTASWFMSCFIGVVPIEATLRIWDCLFYEGS------HILFK 475
+ + P T W+++ F VP LRIWD LF G +L
Sbjct: 305 AEIGAE--------PSAFAT-RWYLTVFHQCVPFHTQLRIWDLLFLLGGSKGQTVRLLQA 355
Query: 476 MSLAIIE 482
SLA+I+
Sbjct: 356 TSLAVIQ 362
>At2g39280 [U] KOG2058 Ypt/Rab GTPase activating protein
Length = 579
Score = 65.5 bits (158), Expect = 2e-10
Identities = 110/448 (24%), Positives = 153/448 (33%), Gaps = 136/448 (30%)
Query: 105 SMKGHKINQNNSGSS-ELELNEGALTLATEDKTINLDDSGSSDALNGIG----QLPTPES 159
S + +N + S E ELN+GA E K +N D GS D G ++P E
Sbjct: 44 SSENTHVNPSESDKKKEKELNKGA-----ERKDLNADKPGS-DLTPGNAREEDEVPNREK 97
Query: 160 ESRASQLLG----NSSLIEDAASIKVK---DSHLDRYGFMKQNQYISEKQY--------- 203
QL + IED S++VK DS K N S +
Sbjct: 98 NVHKVQLWAEIRPSLQAIEDLMSVRVKMKGDSTNGEQEAQKLNSLASTDETESSKGVCEN 157
Query: 204 ---NEWWSEYSKYCIXXXXXXXXXXXXSGLPVDNDS-PSRFPSKSEKLKRYVRKGIPAEW 259
+E++ I D S S P K E L+ + G P
Sbjct: 158 DSEDEFYDAERSDPIQDGSSDGTSVSSMSAAADAASLVSACPWKDE-LEVLIHGGAPMAL 216
Query: 260 RGNAWWYFARGQELLNKNIGVYDKLLT--------------------KINDP-SFTSKDT 298
RG W FA ++ KN Y LL DP S K
Sbjct: 217 RGELWQAFAGVKKRRVKNY--YQNLLAADSLGNDIEQELMQHTDEKGSSTDPLSVVEKWK 274
Query: 299 EIIERDLHRTFPDNIHFQRSKVSSEDPLIIKSLRRILKAFAIYNAKIGYCQ--------- 349
IE+DL RTFP + + D +LRR+L A+A +N +GYCQ
Sbjct: 275 GQIEKDLPRTFPGH--------PALDDDFRNALRRLLTAYARHNPSVGYCQYGYMLTKMN 326
Query: 350 --------------SMNFLVGLLLLFMDEERAFWMLVIMTSRYLPGVHSINLEGVNINQG 395
+MNF LLLL M EE AFW L + Y +S + ++Q
Sbjct: 327 ISVICYLVSINHVQAMNFFAALLLLLMPEENAFWSLTGIIDDYFHDYYSEEMLESQVDQR 386
Query: 396 VLLLCIKEYLPHFWQRIYSNKDQQHSPGLSNKNEFLYKLPPVTLCTASWFMSCFIGVVPI 455
VL ++E P
Sbjct: 387 VLEELLRERFP------------------------------------------------- 397
Query: 456 EATLRIWDCLFYEGSHI-LFKMSLAIIE 482
+ LR+WD L +EG+ + LF+ +LA++E
Sbjct: 398 KLVLRVWDVLLFEGNRVMLFRTALALME 425
>ECU11g1700 [R] KOG1102 Rab6 GTPase activator GAPCenA and related TBC domain
proteins
Length = 320
Score = 64.3 bits (155), Expect = 5e-10
Identities = 68/272 (25%), Positives = 116/272 (42%), Gaps = 46/272 (16%)
Query: 243 KSEKLKRYVRKGIPAEWRGNAWWYFARGQELLNKNIGVYDKLLTKINDPSFTSKDTEIIE 302
+SE +R + +GIP + W F + + Y L+++ S I
Sbjct: 64 RSESARRLIYQGIPLSLKYRLWGLFTQRTSDFD-----YSALISR------KSGYEHQIH 112
Query: 303 RDLHRTFPDNIHFQRSKVSSEDPLIIKSLRRILKAFAIYNAKIGYCQSMNFLVGLLLLFM 362
D+ RTF + F R + L IL A++ YN ++GYCQ M+ LLL++
Sbjct: 113 VDVQRTFRRHFLFSREYGRGQCELF-----NILTAYSNYNPEVGYCQGMSSAAALLLMYF 167
Query: 363 DEERAFWMLV-IMTSRYLPGVHSINLEGVNINQGVLLLCIKEYLPHFWQRIYSNKDQQHS 421
EE AF MLV I+ + +L + L V Q + K +P +YS+
Sbjct: 168 PEEEAFEMLVSIIRNNHLEALFDKKLSKVPRVQKIQDEIFKALIP----EVYSH------ 217
Query: 422 PGLSNKNEFLYKLPPVTLCTASWFMSCFIGVVPIEATLRIWD-CLFYEGSHILF------ 474
L++ + + W+++ F I+ LR+WD LF++ S +F
Sbjct: 218 --------LLHQNIDIGVYAVGWYLTLFTR-FDIKLVLRMWDFFLFFDFSIFMFFAAGIL 268
Query: 475 -KMSLAIIELSETNLPKLNHVSSRNSDDEDME 505
++ I+EL L + + + +S D D+E
Sbjct: 269 KFFAMGILELQGEQL--IEFIGTLDSKDVDVE 298
>CE29557 [U] KOG2058 Ypt/Rab GTPase activating protein
Length = 248
Score = 56.2 bits (134), Expect = 1e-07
Identities = 50/184 (27%), Positives = 78/184 (42%), Gaps = 37/184 (20%)
Query: 184 SHLDRYGFMK----QNQYISEKQYNEWWSEYSKYCIXXXXXXXXXXXXSGLPVDNDSPSR 239
S +D GF++ Q + +KQY W+S Y + + ++P R
Sbjct: 18 SDVDDLGFLRPWSPQEESGCKKQYEAWYSSYLPIVVRRRCRW-----------EKENPRR 66
Query: 240 FPSKSEKLKRYVRKGIPAEWRGNAWWYFARGQELLNKNIGVYDKLLTKINDPSFTSKDTE 299
S L+R+VRKGIP +R W + ++ GV+ + + +
Sbjct: 67 ---NSHLLQRFVRKGIPHTFRKELWL-----RSCPSRADGVWQR-------HEVPDEVIK 111
Query: 300 IIERDLHRTFPDNIHFQRSKVSSEDPLIIKSLRRILKAFAIYNAKIGYCQSMNFLVGLLL 359
I+ DL RTFPDN + K+L R L A A + +GYCQ +NF+ G +L
Sbjct: 112 QIKLDLPRTFPDNKFLKTEGTR-------KTLGRALFAVAEHIPSVGYCQGLNFVAGTVL 164
Query: 360 LFMD 363
D
Sbjct: 165 RLWD 168
>7290543 [R] KOG1093 Predicted protein kinase (contains TBC and RHOD
domains)
Length = 840
Score = 52.0 bits (123), Expect = 3e-06
Identities = 70/252 (27%), Positives = 102/252 (39%), Gaps = 38/252 (15%)
Query: 240 FPSKSEKLKRYVRKGIPAEWRGNAWWYFARGQELLNKNIGVYDKLLTKINDPSFTSKDTE 299
+P +E+L+R +P RG W A E++ G Y K+ FTS T+
Sbjct: 417 YPHTAEQLQREAAVDVPPLLRGPIW---AALLEVVPN--GSYAKI------DKFTSTSTD 465
Query: 300 I-IERDLHRTFPDNIHFQRSKVSSEDPLIIKSLRRILKAFAIYNAKIGYCQSMNFLVG-- 356
IE D+ R H +SS D + LRR+LKA+ + + Y Q ++ L
Sbjct: 466 RQIEVDIPRC-----HQYDELLSSPDGH--RKLRRLLKAWVTAHPQYVYWQGLDSLTAPF 518
Query: 357 LLLLFMDEERAFWMLVIMTSRYLPGVHSINLEGVNINQGVLLLCIKEYLPHFWQRIYSNK 416
L L F +EE AF L +YL + V IKEYL F S
Sbjct: 519 LYLNFNNEELAFLSLFKFIPKYLQWFFLKDNSAV----------IKEYLSKF-----SQL 563
Query: 417 DQQHSPGLSNKNEFLYKLPPVTLCTASWFMSCFIGVVPIEATLRIWDCLFYEGSHILFKM 476
H P L+ + +P L WF++ F V P+ L +WD L S +
Sbjct: 564 TAFHEPLLAQHLASISFIPE--LFAIPWFLTMFSHVFPLHKILHLWDKLMLGDSSYPLFI 621
Query: 477 SLAIIELSETNL 488
+AI+ + L
Sbjct: 622 GIAILRQLRSTL 633
>Hs22062664 [TR] KOG2224 Uncharacterized conserved protein contains TBC domain
Length = 766
Score = 51.6 bits (122), Expect = 3e-06
Identities = 48/188 (25%), Positives = 81/188 (42%), Gaps = 29/188 (15%)
Query: 301 IERDLHRTFPDNIHFQRSKVSSEDPLIIKSLRRILKAFAIYNAKIGYCQSMNFLVG-LLL 359
+++D+ RT +N F+ ED ++S+RRIL +A+YN +GY Q M+ LV +L
Sbjct: 487 VDKDVVRTDRNNQFFR-----GEDNPNVESMRRILLNYAVYNPAVGYSQGMSDLVAPILA 541
Query: 360 LFMDEERAFWMLV--IMTSRYLPGVHSINLEGVNINQGVLLLCIKEYLPHFWQRIYSNKD 417
+DE FW V + + ++ ++E LL ++E L R Y +
Sbjct: 542 EVLDESDTFWCFVGLMQNTIFVSSPRDEDME-------KQLLYLRELLRLTHVRFYQHLV 594
Query: 418 QQHSPGLSNKNEFLYKLPPVTLCTASWFMSCFIGVVPIEATLRIWDCLF--YEGSHILFK 475
GL L W + CF P LRIW+ + Y+ +
Sbjct: 595 SLGEDGLQ------------MLFCHRWLLLCFKREFPEAEALRIWEACWAHYQTDYFHLF 642
Query: 476 MSLAIIEL 483
+ +AI+ +
Sbjct: 643 ICVAIVAI 650
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.317 0.134 0.389
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 36,216,422
Number of Sequences: 60738
Number of extensions: 1549759
Number of successful extensions: 4539
Number of sequences better than 1.0e-05: 62
Number of HSP's better than 0.0 without gapping: 32
Number of HSP's successfully gapped in prelim test: 30
Number of HSP's that attempted gapping in prelim test: 4346
Number of HSP's gapped (non-prelim): 76
length of query: 619
length of database: 30,389,216
effective HSP length: 112
effective length of query: 507
effective length of database: 23,586,560
effective search space: 11958385920
effective search space used: 11958385920
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)