ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactI2085 check: MH U KOG1092 Intracellular trafficking, secretion, and vesicular transport Ypt/Rab-specific GTPase-activating protein GYP1
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactI2085 709271 710908 546
(546 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YOR070c [U] KOG1092 Ypt/Rab-specific GTPase-activating protein GYP1 585 e-167
SPBC530.01 [U] KOG1092 Ypt/Rab-specific GTPase-activating protei... 359 7e-99
At2g30710 [U] KOG1092 Ypt/Rab-specific GTPase-activating protein... 311 2e-84
Hs18594431 [U] KOG1092 Ypt/Rab-specific GTPase-activating protei... 287 3e-77
7300700 [U] KOG1092 Ypt/Rab-specific GTPase-activating protein GYP1 270 5e-72
CE09863 [U] KOG1092 Ypt/Rab-specific GTPase-activating protein GYP1 266 5e-71
Hs8923314 [U] KOG1092 Ypt/Rab-specific GTPase-activating protein... 150 4e-36
At1g04830 [R] KOG4567 GTPase-activating protein 99 1e-20
ECU04g1530 [U] KOG1092 Ypt/Rab-specific GTPase-activating protei... 98 4e-20
At4g13730 [R] KOG4567 GTPase-activating protein 91 4e-18
7295061 [R] KOG4567 GTPase-activating protein 84 4e-16
At2g43490_1 [T] KOG2197 Ypt/Rab-specific GTPase-activating prote... 84 7e-16
At3g59570 [T] KOG2197 Ypt/Rab-specific GTPase-activating protein... 82 3e-15
ECU03g0560 [R] KOG4567 GTPase-activating protein 76 1e-13
Hs21361637 [R] KOG4567 GTPase-activating protein 74 4e-13
HsM12232451 [T] KOG2197 Ypt/Rab-specific GTPase-activating prote... 74 7e-13
At5g52590 [T] KOG2197 Ypt/Rab-specific GTPase-activating protein... 74 7e-13
Hs21362084 [T] KOG2197 Ypt/Rab-specific GTPase-activating protei... 73 1e-12
SPAC1952.17c [R] KOG4567 GTPase-activating protein 71 4e-12
Hs22062664 [TR] KOG2224 Uncharacterized conserved protein contai... 70 6e-12
Hs13375952 [T] KOG2197 Ypt/Rab-specific GTPase-activating protei... 66 2e-10
CE28983 [R] KOG1102 Rab6 GTPase activator GAPCenA and related TB... 65 2e-10
7296240 [T] KOG2197 Ypt/Rab-specific GTPase-activating protein G... 65 3e-10
7299738 [U] KOG1091 Ypt/Rab-specific GTPase-activating protein GYP6 62 2e-09
Hs22056446 [U] KOG2058 Ypt/Rab GTPase activating protein 61 4e-09
Hs14916463 [R] KOG1093 Predicted protein kinase (contains TBC an... 59 1e-08
CE14882 [T] KOG2197 Ypt/Rab-specific GTPase-activating protein G... 57 5e-08
At5g54780 [T] KOG2197 Ypt/Rab-specific GTPase-activating protein... 56 1e-07
At5g24390 [T] KOG2197 Ypt/Rab-specific GTPase-activating protein... 55 2e-07
CE29383 [TR] KOG2224 Uncharacterized conserved protein contains ... 54 5e-07
Hs7661998 [U] KOG1091 Ypt/Rab-specific GTPase-activating protein... 53 1e-06
7290543 [R] KOG1093 Predicted protein kinase (contains TBC and R... 53 1e-06
At5g41940 [T] KOG2197 Ypt/Rab-specific GTPase-activating protein... 52 2e-06
SPCC1259.11c [R] KOG4347 GTPase-activating protein VRP 51 4e-06
>YOR070c [U] KOG1092 Ypt/Rab-specific GTPase-activating protein GYP1
Length = 637
Score = 585 bits (1509), Expect = e-167
Identities = 294/490 (60%), Positives = 348/490 (71%), Gaps = 39/490 (7%)
Query: 92 DKYFKDLDEDWSAVIDDYNMPIPMINNGGIETTLRPPAVIQDDRAIES------------ 139
D+YFKDLDEDWSAVIDDYNMPIP++ NGG T + P + S
Sbjct: 150 DRYFKDLDEDWSAVIDDYNMPIPILTNGGFGTPVAPTRTLSRKSTSSSINSISNMGTSAV 209
Query: 140 QKSSMDSYQGTIPNLNRTISNDLK-LQYQIEVEKDVQELNSLMVRIEKFKKLIKPKDSTT 198
+ SS +P L + +ND K Q +IE E+DVQELNS++ RI KF ++K K T
Sbjct: 210 RNSSSSFTYPQLPQLQKEKTNDSKKTQLEIENERDVQELNSIIQRISKFDNILKDK---T 266
Query: 199 QVNLPEIRKLAWNGIPMVHRPVVWKLLIGYLPSNLKRQEQVLNRKRLEYKQGVDHIFSDN 258
+N ++R+++WNGIP +HRPVVWKLLIGYLP N KRQE L RKR EY+ + H FSD
Sbjct: 267 IINQQDLRQISWNGIPKIHRPVVWKLLIGYLPVNTKRQEGFLQRKRKEYRDSLKHTFSDQ 326
Query: 259 HEKDVTTWHQIEIDIPRTNPHIPLYQFESVHNSLKRILYFWAIRHPASGYVQGINDLVTP 318
H +D+ TWHQIEIDIPRTNPHIPLYQF+SV NSL+RILY WAIRHPASGYVQGINDLVTP
Sbjct: 327 HSRDIPTWHQIEIDIPRTNPHIPLYQFKSVQNSLQRILYLWAIRHPASGYVQGINDLVTP 386
Query: 319 FFQVFLSEYLSPSAKDDVYSLDPLTYLTAEQLSDVEADCFWCLSKLLEQITDYFIHGQPG 378
FF+ FL+EYL PS DDV DP TY+ EQ++D+EAD FWCL+KLLEQITD +IHGQPG
Sbjct: 387 FFETFLTEYLPPSQIDDVEIKDPSTYMVDEQITDLEADTFWCLTKLLEQITDNYIHGQPG 446
Query: 379 ILKQVKHLSQLVKRIDCDLFSHFESEHVEFLQFSVRWMNCLLMREFQMSMVIRMWDTYLS 438
IL+QVK+LSQLVKRID DL++HF++EHVEF+QF+ RWMNCLLMREFQM VIRMWDTYLS
Sbjct: 447 ILRQVKNLSQLVKRIDADLYNHFQNEHVEFIQFAFRWMNCLLMREFQMGTVIRMWDTYLS 506
Query: 439 ETSLET----SIVSEDLMS-------------------DASTSLDXXXXXXXXXXXXXXX 475
ETS E S+ S D+ + T+
Sbjct: 507 ETSQEVTSSYSMSSNDIKPPVTPTEPRVASFVTPTKDFQSPTTALSNMTPNNAVEDSGKM 566
Query: 476 XXXXLSEFHVFVCAAFLVKWSDELMKMDFQEIITFLQNPPTKSWKESDIEMLLSEAYIWQ 535
L+EFHVFVCAAFL+KWSD+LM+MDFQE ITFLQNPPTK W E+DIEMLLSEA+IWQ
Sbjct: 567 RQSSLNEFHVFVCAAFLIKWSDQLMEMDFQETITFLQNPPTKDWTETDIEMLLSEAFIWQ 626
Query: 536 SLYKDATSHW 545
SLYKDATSHW
Sbjct: 627 SLYKDATSHW 636
>SPBC530.01 [U] KOG1092 Ypt/Rab-specific GTPase-activating protein GYP1
Length = 514
Score = 359 bits (921), Expect = 7e-99
Identities = 191/382 (50%), Positives = 235/382 (61%), Gaps = 55/382 (14%)
Query: 170 VEKDVQELNSLMVRIEKFKKLIKPKDSTTQVNLPEIRKLAWNGIPMVHRPVVWKLLIGYL 229
VE +V E N+L+ RI+KF +++ V+L +R LAWNGIP HRP+VWK L+GYL
Sbjct: 178 VEVEVAESNALVSRIKKFSRIL----DAPIVDLNALRTLAWNGIPSEHRPIVWKYLLGYL 233
Query: 230 PSNLKRQEQVLNRKRLEYKQGVDHIFSDNHEK---DVTTWHQIEIDIPRTNPHIPLYQFE 286
P N R+E L RKR EY D F+ N E D T W QI +D+PRTNP I LYQ
Sbjct: 234 PCNASRREVTLKRKRDEYNAAKDSCFNTNTEPPPLDQTIWRQIVLDVPRTNPSILLYQNP 293
Query: 287 SVHNSLKRILYFWAIRHPASGYVQGINDLVTPFFQVFLSEYLSPSAKDDVYSLDPLTY-- 344
L+RILY WA RHPASGYVQGI+DLVTPF QVFLSEY+ DP+TY
Sbjct: 294 LTQRMLERILYVWASRHPASGYVQGISDLVTPFIQVFLSEYIGDK--------DPMTYDI 345
Query: 345 --LTAEQLSDVEADCFWCLSKLLEQITDYFIHGQPGILKQVKHLSQLVKRIDCDLFSHFE 402
L +D+EAD +WCLSKLL+ I D +IH QPGI +QV +L +L RID L H +
Sbjct: 346 ALLDETNRNDIEADAYWCLSKLLDGIQDNYIHAQPGIRRQVNNLRELTLRIDEPLVKHLQ 405
Query: 403 SEHVEFLQFSVRWMNCLLMREFQMSMVIRMWDTYLSETSLETSIVSEDLMSDASTSLDXX 462
E V+FLQFS RWMNCLLMRE +S +IRMWDTY++E
Sbjct: 406 MEGVDFLQFSFRWMNCLLMRELSISNIIRMWDTYMAE----------------------- 442
Query: 463 XXXXXXXXXXXXXXXXXLSEFHVFVCAAFLVKWSDELMKMDFQEIITFLQNPPTKSWKES 522
SEFH++VCAAFLVKWS EL KM+FQ+I+ FLQ+ PTK W
Sbjct: 443 -------------GVQGFSEFHLYVCAAFLVKWSSELQKMEFQDILIFLQSIPTKDWSTK 489
Query: 523 DIEMLLSEAYIWQSLYKDATSH 544
DIE+LLSEA++W+SLY A +H
Sbjct: 490 DIEILLSEAFLWKSLYSGAGAH 511
>At2g30710 [U] KOG1092 Ypt/Rab-specific GTPase-activating protein GYP1
Length = 343
Score = 311 bits (796), Expect = 2e-84
Identities = 158/353 (44%), Positives = 223/353 (62%), Gaps = 46/353 (13%)
Query: 196 STTQVNLPEIRKLAWNGIPMVHRPVVWKLLIGYLPSNLKRQEQVLNRKRLEYKQGVDHIF 255
+++ + ++R+LAWNG+P RP VW+LL+GY P N R+E VL RKRLEY + V +
Sbjct: 30 NSSSIPAEKLRELAWNGVPHYMRPDVWRLLLGYAPPNSDRREAVLRRKRLEYLESVGQFY 89
Query: 256 ----SDNHEKDVTTWHQIEIDIPRTNPHIPLYQFESVHNSLKRILYFWAIRHPASGYVQG 311
S+ + ++ QI +D PRT P + +Q E V SL+RILY WAIRHPASGYVQG
Sbjct: 90 DLPDSERSDDEINMLRQIAVDCPRTVPDVSFFQQEQVQKSLERILYTWAIRHPASGYVQG 149
Query: 312 INDLVTPFFQVFLSEYLSPSAKDDVYSLDPLTYLTAEQLSDVEADCFWCLSKLLEQITDY 371
INDLVTPF +FLSEYL D +S+D L+ AE++SDVEADC+WCL+KLL+ + D+
Sbjct: 150 INDLVTPFLVIFLSEYLDGGV--DSWSMDDLS---AEKVSDVEADCYWCLTKLLDGMQDH 204
Query: 372 FIHGQPGILKQVKHLSQLVKRIDCDLFSHFESEHVEFLQFSVRWMNCLLMREFQMSMVIR 431
+ QPGI + V L +LV+RID + H E +EFLQF+ RW NCLL+RE +++ R
Sbjct: 205 YTFAQPGIQRLVFKLKELVRRIDEPVSRHMEEHGLEFLQFAFRWYNCLLIREIPFNLINR 264
Query: 432 MWDTYLSETSLETSIVSEDLMSDASTSLDXXXXXXXXXXXXXXXXXXXLSEFHVFVCAAF 491
+WDTYL+E DA L +F V++ A+F
Sbjct: 265 LWDTYLAE-------------GDA------------------------LPDFLVYIYASF 287
Query: 492 LVKWSDELMKMDFQEIITFLQNPPTKSWKESDIEMLLSEAYIWQSLYKDATSH 544
L+ WSDEL K+DFQE++ FLQ+ PT +W + ++EM+LS AY+W S++ ++ +H
Sbjct: 288 LLTWSDELKKLDFQEMVMFLQHLPTHNWSDQELEMVLSRAYMWHSMFNNSPNH 340
>Hs18594431 [U] KOG1092 Ypt/Rab-specific GTPase-activating protein GYP1
Length = 517
Score = 287 bits (734), Expect = 3e-77
Identities = 157/366 (42%), Positives = 216/366 (58%), Gaps = 48/366 (13%)
Query: 183 RIEKFKKLIKPKDSTTQVNLPEIRKLAWNGIPMVHRPVVWKLLIGYLPSNLKRQEQVLNR 242
R++KFK+L+ ++ +L E+R+L+W+GIP RP+ WKLL GYLP+N+ R+ L R
Sbjct: 197 RLDKFKQLLAGPNT----DLEELRRLSWSGIPKPVRPMTWKLLSGYLPANVDRRPATLQR 252
Query: 243 KRLEYKQGVDHIF-SDNHEKDVTTWHQIEIDIPRTNPHIPLYQFESVHNSLKRILYFWAI 301
K+ EY ++H + S N E T+ QI IDIPR +P + Q V +RIL+ WAI
Sbjct: 253 KQKEYFAFIEHYYDSRNDEVHQDTYRQIHIDIPRMSPEALILQ-PKVTEIFERILFIWAI 311
Query: 302 RHPASGYVQGINDLVTPFFQVFLSEYLSPSAKDDVYSLDPLTYLTAEQLSDVEADCFWCL 361
RHPASGYVQGINDLVTPFF VF+ EY+ D V ++ + AE L ++EAD +WC+
Sbjct: 312 RHPASGYVQGINDLVTPFFVVFICEYIEAEEVDTV----DVSGVPAEVLCNIEADTYWCM 367
Query: 362 SKLLEQITDYFIHGQPGILKQVKHLSQLVKRIDCDLFSHFESEHVEFLQFSVRWMNCLLM 421
SKLL+ I D + QPGI +VK L +LV RID + H + V +LQF+ RWMN LLM
Sbjct: 368 SKLLDGIQDNYTFAQPGIQMKVKMLEELVSRIDEQVHRHLDQHEVRYLQFAFRWMNNLLM 427
Query: 422 REFQMSMVIRMWDTYLSETSLETSIVSEDLMSDASTSLDXXXXXXXXXXXXXXXXXXXLS 481
RE + IR+WDTY SE S
Sbjct: 428 REVPLRCTIRLWDTYQSEPD-------------------------------------GFS 450
Query: 482 EFHVFVCAAFLVKWSDELM-KMDFQEIITFLQNPPTKSWKESDIEMLLSEAYIWQSLYKD 540
FH++VCAAFLV+W E++ + DFQE++ FLQN PT W + DI +LL+EAY + + D
Sbjct: 451 HFHLYVCAAFLVRWRKEILEEKDFQELLLFLQNLPTAHWDDEDISLLLAEAYRLKFAFAD 510
Query: 541 ATSHWR 546
A +H++
Sbjct: 511 APNHYK 516
>7300700 [U] KOG1092 Ypt/Rab-specific GTPase-activating protein GYP1
Length = 545
Score = 270 bits (689), Expect = 5e-72
Identities = 158/408 (38%), Positives = 227/408 (54%), Gaps = 64/408 (15%)
Query: 141 KSSMDSYQGTIPNLNRTISNDLKLQYQIEVEKDVQELNSLMVRIEKFKKLIKPKDSTTQV 200
+S + +Y G P L + SN +Y+ +IEKF+ ++ + Q+
Sbjct: 193 RSRLRNYPGR-PQLQKISSNCQDSEYE--------------TKIEKFQVVL----DSPQL 233
Query: 201 NLPEIRKLAWNGIPMVHRPVVWKLLIGYLPSNLKRQEQVLNRKRLEYKQGVDHIFSDNHE 260
+L ++K++W+G+P R V W+LL YLP + +R+ VL KR Y Q + H +
Sbjct: 234 DLVALKKISWSGVPRKMRAVSWRLLSKYLPPSSERRMAVLESKRQGY-QDLRHNYFRVDS 292
Query: 261 KDVT---TWHQIEIDIPRTNPHIPLYQFESVHNSLKRILYFWAIRHPASGYVQGINDLVT 317
+D T T+ QI ID+PR NP IPL+Q + V +RIL+ WAIRHPASGYVQGINDLVT
Sbjct: 293 QDETQQDTYRQIHIDVPRMNPQIPLFQQQLVQEMFERILFIWAIRHPASGYVQGINDLVT 352
Query: 318 PFFQVFLSEYLSPSAKDDVYSLDPLTYLTAEQLSDVEADCFWCLSKLLEQITDYFIHGQP 377
PFF VFL E L+P+ + Y ++ L E + +EAD FWCLSK L+ I D +I Q
Sbjct: 353 PFFIVFLQEALTPNTDLEKYD---MSTLPEETRNIIEADSFWCLSKFLDCIQDNYIFAQL 409
Query: 378 GILKQVKHLSQLVKRIDCDLFSHFESEHVEFLQFSVRWMNCLLMREFQMSMVIRMWDTYL 437
GI ++V L L++RID +L H ++ V++LQFS RWMN LL RE + IR+WDTYL
Sbjct: 410 GIQEKVNQLKDLIQRIDVNLHRHLQAHGVDYLQFSFRWMNNLLTRELPLHCTIRLWDTYL 469
Query: 438 SETSLETSIVSEDLMSDASTSLDXXXXXXXXXXXXXXXXXXXLSEFHVFVCAAFLVKWSD 497
+E+ + FH++VCAAFL+ W +
Sbjct: 470 AESD-------------------------------------GFALFHLYVCAAFLLHWKE 492
Query: 498 ELMKM-DFQEIITFLQNPPTKSWKESDIEMLLSEAYIWQSLYKDATSH 544
+LM+ DFQ ++ LQN PT +W + I +LL+EA+ + Y DA H
Sbjct: 493 QLMQQNDFQGLMLLLQNLPTHNWSDRQINVLLAEAFRLKFTYADAPKH 540
>CE09863 [U] KOG1092 Ypt/Rab-specific GTPase-activating protein GYP1
Length = 495
Score = 266 bits (681), Expect = 5e-71
Identities = 151/347 (43%), Positives = 199/347 (56%), Gaps = 42/347 (12%)
Query: 200 VNLPEIRKLAWNGIPMVHRPVVWKLLIGYLPSNLKRQEQVLNRKRLEYKQGVDHIFSDNH 259
V+L ++R+ W GIP RP W+LL GYLP+N +R+E L KR EY V+ F
Sbjct: 181 VDLEKLREDCWMGIPHKLRPQAWRLLSGYLPTNAERREVTLQCKRDEYWHYVEQYFHSRF 240
Query: 260 E-KDVTTWHQIEIDIPRTNPHIPLYQFESVHNSLKRILYFWAIRHPASGYVQGINDLVTP 318
+ ++ T+ QI IDIPR P IPL+Q + V +RILY WAIRHPASGYVQGINDLVTP
Sbjct: 241 DDQNADTFRQINIDIPRMCPLIPLFQQKMVQEMFERILYIWAIRHPASGYVQGINDLVTP 300
Query: 319 FFQVFLSEYLSPSAKDDVYSLDPLTYLTAEQLSDVEADCFWCLSKLLEQITDYFIHGQPG 378
FF VFLSE++ +V S D ++ L EQ +EAD FWC+S LL+ I D + QPG
Sbjct: 301 FFVVFLSEFIPQDV--EVGSFD-VSQLPLEQCQLIEADSFWCVSSLLDSIQDNYTFAQPG 357
Query: 379 ILKQVKHLSQLVKRIDCDLFSHFESEHVEFLQFSVRWMNCLLMREFQMSMVIRMWDTYLS 438
I ++V L L+ R+D L H ES +E+LQF+ RWMN LLMRE + IR+WDTYLS
Sbjct: 358 IQRKVLQLRHLMSRVDRPLHKHLESNGIEYLQFAFRWMNNLLMREIPLRATIRLWDTYLS 417
Query: 439 ETSLETSIVSEDLMSDASTSLDXXXXXXXXXXXXXXXXXXXLSEFHVFVCAAFLVKWSDE 498
E +FH +VCAAFL WS +
Sbjct: 418 EPD-------------------------------------GFMQFHNYVCAAFLRTWSKQ 440
Query: 499 LM-KMDFQEIITFLQNPPTKSWKESDIEMLLSEAYIWQSLYKDATSH 544
L + DFQ ++ LQN PT+SW + +I L ++A+ QS++ A H
Sbjct: 441 LQAEKDFQGVMILLQNLPTQSWGDREICELTADAFSLQSVFDGARRH 487
>Hs8923314 [U] KOG1092 Ypt/Rab-specific GTPase-activating protein GYP1
Length = 163
Score = 150 bits (380), Expect = 4e-36
Identities = 81/198 (40%), Positives = 109/198 (54%), Gaps = 38/198 (19%)
Query: 350 LSDVEADCFWCLSKLLEQITDYFIHGQPGILKQVKHLSQLVKRIDCDLFSHFESEHVEFL 409
L +EAD FWC+SKLL+ I D + QPGI K+VK L +LV RID + +HF VE+L
Sbjct: 2 LRSIEADSFWCMSKLLDGIQDNYTFAQPGIQKKVKALEELVSRIDEQVHNHFRRYEVEYL 61
Query: 410 QFSVRWMNCLLMREFQMSMVIRMWDTYLSETSLETSIVSEDLMSDASTSLDXXXXXXXXX 469
QF+ RWMN LLMRE + IR+WDTY SE
Sbjct: 62 QFAFRWMNNLLMRELPLRCTIRLWDTYQSEPE---------------------------- 93
Query: 470 XXXXXXXXXXLSEFHVFVCAAFLVKWSDELM-KMDFQEIITFLQNPPTKSWKESDIEMLL 528
S FH++VCAAFL+KW E++ + DFQ ++ LQN PT W +I +LL
Sbjct: 94 ---------GFSHFHLYVCAAFLIKWRKEILDEEDFQGLLMLLQNLPTIHWGNEEIGLLL 144
Query: 529 SEAYIWQSLYKDATSHWR 546
+EAY + ++ DA +H+R
Sbjct: 145 AEAYRLKYMFADAPNHYR 162
>At1g04830 [R] KOG4567 GTPase-activating protein
Length = 451
Score = 99.4 bits (246), Expect = 1e-20
Identities = 83/303 (27%), Positives = 126/303 (41%), Gaps = 81/303 (26%)
Query: 200 VNLPEIRKLAWNGIPMVH--RPVVWKLLIGYLPSNLKRQEQVLNRKRLEYKQGVDHIFS- 256
+N+ E+R LA +P R VWKLL+GYLP L +KR +YK D + +
Sbjct: 108 INMKELRSLALQSLPDSPGIRSTVWKLLLGYLPPERSLWSTELKQKRSQYKHYKDELLTS 167
Query: 257 -----------------DNHE---------------------------------KDVTTW 266
DN++ +D T
Sbjct: 168 PVSDPEITWKMVRSKGFDNYDLKSESRCMLARSRITDEDHPLSLGKASIWNTYFQDTETI 227
Query: 267 HQIEIDIPRTNPHIPLYQFESV-----HNSLKRILYFWAIRHPASGYVQGINDLVTPFFQ 321
QI+ D+ RT+P IP + ES S+K IL +A + YVQG+N+++ P F
Sbjct: 228 EQIDRDVKRTHPDIPFFSGESSFARSNQESMKNILLVFAKLNQGIRYVQGMNEILAPIFY 287
Query: 322 VFLSEYLSPSAKDDVYSLDPLTYLTAEQLSDVEADCFWCLSKLLEQITDYFI----HGQP 377
VF + DP + S EAD F+C +LL D++ +
Sbjct: 288 VFRN--------------DP----DEDSSSHAEADAFFCFVELLSGFRDFYCQQLDNSVV 329
Query: 378 GILKQVKHLSQLVKRIDCDLFSHFE-SEHVEFLQFSVRWMNCLLMREFQMSMVIRMWDTY 436
GI + LSQLV++ D +L+ H E + V ++ RW+ LL +EF + +WD
Sbjct: 330 GIRSAITRLSQLVRKHDEELWRHLEITTKVNPQFYAFRWITLLLTQEFSFFDSLHIWDAL 389
Query: 437 LSE 439
LS+
Sbjct: 390 LSD 392
>ECU04g1530 [U] KOG1092 Ypt/Rab-specific GTPase-activating protein GYP1
Length = 329
Score = 97.8 bits (242), Expect = 4e-20
Identities = 66/271 (24%), Positives = 124/271 (45%), Gaps = 63/271 (23%)
Query: 267 HQIEIDIPRTNPHIPLYQFESVHNSLKRILYFWAIRHPASGYVQGINDLVTPFFQVFLSE 326
HQI++DI R + Y + R+L+ A + P GY+QG+ D++ PF VFL+E
Sbjct: 110 HQIDLDIRRIDLRYRSYLGTDISYMYYRVLWLVAHKRPLLGYIQGMADILIPFILVFLNE 169
Query: 327 YLSPSAKDDVYSLDPLTYLTAEQLSDVEADCFWCLSKLLEQITDYFIHGQPGILKQVKHL 386
AE+ E++ ++C ++LL++I + Q G+ ++ L
Sbjct: 170 -------------------NAER---AESNAYFCYARLLDEIQYNMVELQSGM---IEGL 204
Query: 387 SQLVKRIDCDLFSHFESEHVEFLQFSVRWMNCLLMREFQMSMVIRMWDTYLSETSLETSI 446
+++ +D D + +E F+ RW NCL +REF++ +++++ DT + S+ S+
Sbjct: 205 DFVLQTVDPDFHKFLQEIGLEIHMFAFRWFNCLFVREFKVPILLKILDTIFASDSINESL 264
Query: 447 VSEDLMSDASTSLDXXXXXXXXXXXXXXXXXXXLSEFHVFVCAAFLVKWSDELMKMDFQE 506
V+ A L+K+ L++ DF
Sbjct: 265 --------------------------------------VYFGVALLMKFKSTLVENDFSH 286
Query: 507 IITFLQNPPTKSWKESDIEMLLSEAYIWQSL 537
I FLQ+ + W+E++IE++LS A ++ +
Sbjct: 287 NILFLQSIYDREWEEAEIELILSSAKFYRKV 317
>At4g13730 [R] KOG4567 GTPase-activating protein
Length = 449
Score = 90.9 bits (224), Expect = 4e-18
Identities = 79/300 (26%), Positives = 126/300 (41%), Gaps = 78/300 (26%)
Query: 200 VNLPEIRKLAWNGIP--MVHRPVVWKLLIGYLPSNLKRQEQVLNRKRLEYKQ-------- 249
++L E+RK+A G+P R +VWKLL+ YL + L +KR +YKQ
Sbjct: 112 IDLKELRKIASQGLPDDAGIRSIVWKLLLDYLSPDRSLWSSELAKKRSQYKQFKEELLMN 171
Query: 250 ---------------------------------GVDHIFS-------DNHEKDVTTWHQI 269
DH S +N KD QI
Sbjct: 172 PSEVTRKMDKSKGGDSNDPKIESPGALSRSEITHEDHPLSLGTTSLWNNFFKDTEVLEQI 231
Query: 270 EIDIPRTNPHIPLYQFESV-----HNSLKRILYFWAIRHPASGYVQGINDLVTPFFQVFL 324
E D+ RT+P + + +S ++LK IL +A +P YVQG+N+++ P F +F
Sbjct: 232 ERDVMRTHPDMHFFSGDSAVAKSNQDALKNILTIFAKLNPGIRYVQGMNEILAPIFYIFK 291
Query: 325 SEYLSPSAKDDVYSLDPLTYLTAEQLSDVEADCFWCLSKLLEQITDYFI----HGQPGIL 380
++ P + Y+ E+D F+C +L+ D F + GI
Sbjct: 292 ND---PDKGNAAYA---------------ESDAFFCFVELMSGFRDNFCQQLDNSVVGIR 333
Query: 381 KQVKHLSQLVKRIDCDLFSHFE-SEHVEFLQFSVRWMNCLLMREFQMSMVIRMWDTYLSE 439
+ LS L+K D +L+ H E + + ++ RW+ LL +EF + +WDT LS+
Sbjct: 334 YTITRLSLLLKHHDEELWRHLEVTTKINPQFYAFRWITLLLTQEFNFVESLHIWDTLLSD 393
>7295061 [R] KOG4567 GTPase-activating protein
Length = 403
Score = 84.3 bits (207), Expect = 4e-16
Identities = 47/152 (30%), Positives = 80/152 (51%), Gaps = 22/152 (14%)
Query: 292 LKRILYFWAIRHPASGYVQGINDLVTPFFQVFLSEYLSPSAKDDVYSLDPLTYLTAEQLS 351
++RIL+ +A +P GYVQG+N++V P + V S+ LTY +
Sbjct: 217 VQRILFIYAKLNPGQGYVQGMNEIVGPIYYVMASD-------------PDLTYR-----A 258
Query: 352 DVEADCFWCLSKLLEQITDYFIH----GQPGILKQVKHLSQLVKRIDCDLFSHFESEHVE 407
EADCF+C + L+ +I D+FI + GI + LS ++K D ++ S+ +
Sbjct: 259 HAEADCFFCFTALMSEIRDFFIKTLDDAEGGIKFMMARLSNMLKSKDLSIYELLRSQELH 318
Query: 408 FLQFSVRWMNCLLMREFQMSMVIRMWDTYLSE 439
+S RW+ LL +EF + V+R+WD+ ++
Sbjct: 319 PQYYSFRWLTLLLSQEFPLPDVLRIWDSVFAD 350
>At2g43490_1 [T] KOG2197 Ypt/Rab-specific GTPase-activating protein GYP7 and
related proteins
Length = 500
Score = 83.6 bits (205), Expect = 7e-16
Identities = 51/185 (27%), Positives = 85/185 (45%), Gaps = 29/185 (15%)
Query: 251 VDHIFSDNHEKDVTTWHQIEIDIPRTNPHIPLYQFESVHNSLKRILYFWAIRHPASGYVQ 310
V ++ D + + T H+I +D+ RT+ H+ Y+ + IL +A PA+GY Q
Sbjct: 344 VGNVTEDRVSEWLWTLHRIVVDVVRTDSHLEFYEDPGNLGRMSDILAVYAWVDPATGYCQ 403
Query: 311 GINDLVTPFFQVFLSEYLSPSAKDDVYSLDPLTYLTAEQLSDVEADCFWCLSKLLEQITD 370
G++DLV+PF +F + AD FWC L+ +
Sbjct: 404 GMSDLVSPFVVLF----------------------------EDNADAFWCFEMLIRRTRA 435
Query: 371 YF-IHGQPGILKQVKHLSQLVKRIDCDLFSHFESEHVEFLQFSVRWMNCLLMREFQMSMV 429
F + G G++ Q++ L +++ D D+FSH E L F+ R + L RE +
Sbjct: 436 NFQMEGPTGVMDQLQSLWHILQITDKDIFSHLSRIGAESLHFAFRMLLVLFRRELSFNEA 495
Query: 430 IRMWD 434
+RMW+
Sbjct: 496 LRMWE 500
>At3g59570 [T] KOG2197 Ypt/Rab-specific GTPase-activating protein GYP7 and
related proteins
Length = 549
Score = 81.6 bits (200), Expect = 3e-15
Identities = 51/171 (29%), Positives = 81/171 (46%), Gaps = 29/171 (16%)
Query: 265 TWHQIEIDIPRTNPHIPLYQFESVHNSLKRILYFWAIRHPASGYVQGINDLVTPFFQVFL 324
T H+I +D+ RT+ H+ Y+ + IL +A PA+GY QG++DLV+PF VFL
Sbjct: 388 TLHRIVVDVVRTDSHLEFYEDPGNLGRMSDILAVYAWVDPATGYCQGMSDLVSPF--VFL 445
Query: 325 SEYLSPSAKDDVYSLDPLTYLTAEQLSDVEADCFWCLSKLLEQITDYF-IHGQPGILKQV 383
E AD FWC L+ + F + G G++ Q+
Sbjct: 446 FED--------------------------NADAFWCFEMLIRRTRANFQMEGPTGVMDQL 479
Query: 384 KHLSQLVKRIDCDLFSHFESEHVEFLQFSVRWMNCLLMREFQMSMVIRMWD 434
+ L ++++ D ++FSH E L F+ R + L RE + +RMW+
Sbjct: 480 QSLWRILQLTDKEMFSHLSRIGAESLHFAFRMLLVLFRRELSFNKALRMWE 530
>ECU03g0560 [R] KOG4567 GTPase-activating protein
Length = 336
Score = 75.9 bits (185), Expect = 1e-13
Identities = 69/277 (24%), Positives = 121/277 (42%), Gaps = 45/277 (16%)
Query: 189 KLIKPKDSTTQVNLPEIRKLAWNGIPMVH-RPVVWKLLIGYLPSNLKRQEQVLNRKRLEY 247
K I P DST +++ E++K + G RP WK+ +GY N R E L R Y
Sbjct: 18 KQINPTDSTP-LDVREVKKYCYYGFSNASLRPKYWKVFLGYYSKNKFRTEMFLRNMRSSY 76
Query: 248 KQGVDHIFSDNHEKDVTTWHQIEIDIPRT--NPHIPLYQ----------FESVHNS---- 291
+ I + KD + IE D+ RT P +S+H
Sbjct: 77 SFYIGKIGDEFEGKD-GCYKVIENDVCRTFIKPRTECKDSGEKRRYCEFLDSIHRDTQET 135
Query: 292 ----LKRILYFWAIRHPASGYVQGINDLVTPFFQVFLSEYLSPSAKDDVYSLDPLTYLTA 347
++RIL +A+ + + YVQG+N ++T + V YLS +D Y
Sbjct: 136 HRAVIERILKCYAMTNSSVKYVQGMNLVLTAIYYVL---YLSEDEEDRRYC--------- 183
Query: 348 EQLSDVEADCFWCLSKLLEQITDYFIHG----QPGILKQVKHLSQLVKRIDCDLFSHFES 403
E D F+C + L+ +I D F+ GI+ ++ + ++V+ D +L+ +
Sbjct: 184 ------EEDSFFCFNSLMVEIGDNFMEDLDQCSGGIVHRMSRVMEIVEEADRELYRAMKR 237
Query: 404 EHVEFLQFSVRWMNCLLMREFQMSMVIRMWDTYLSET 440
+ + F ++W+ + + F + V+ +WD LS++
Sbjct: 238 KGLVEGGFHMKWILLMFVSCFDIEDVVWLWDRLLSDS 274
>Hs21361637 [R] KOG4567 GTPase-activating protein
Length = 400
Score = 74.3 bits (181), Expect = 4e-13
Identities = 44/152 (28%), Positives = 79/152 (51%), Gaps = 22/152 (14%)
Query: 292 LKRILYFWAIRHPASGYVQGINDLVTPFFQVFLSEYLSPSAKDDVYSLDPLTYLTAEQLS 351
++RIL+ +A +P YVQG+N++V P + F + DP +E
Sbjct: 211 VERILFIYAKLNPGIAYVQGMNEIVGPLYYTFAT--------------DP----NSEWKE 252
Query: 352 DVEADCFWCLSKLLEQITDYFIHG----QPGILKQVKHLSQLVKRIDCDLFSHFESEHVE 407
EAD F+C + L+ +I D FI Q GI +++ + +K D +L+ + ++++
Sbjct: 253 HAEADTFFCFTNLMAEIRDNFIKSLDDSQCGITYKMEKVYSTLKDKDVELYLKLQEQNIK 312
Query: 408 FLQFSVRWMNCLLMREFQMSMVIRMWDTYLSE 439
F+ RW+ LL +EF + VIR+WD+ ++
Sbjct: 313 PQFFAFRWLTLLLSQEFLLPDVIRIWDSLFAD 344
>HsM12232451 [T] KOG2197 Ypt/Rab-specific GTPase-activating protein GYP7 and
related proteins
Length = 674
Score = 73.6 bits (179), Expect = 7e-13
Identities = 69/275 (25%), Positives = 117/275 (42%), Gaps = 53/275 (19%)
Query: 182 VRIEKFKKLIKPKDSTTQV-NLPEIRKLAWNG-IPMVHRPVVWKLLIGYLPSNLKRQEQV 239
V +E++ K I DS ++ N+ ++++ + G + R WK L+GY P + ++E
Sbjct: 300 VSLEEWTKNI---DSEGRILNVDNMKQMIFRGGLSHALRKQAWKFLLGYFPWDSTKEE-- 354
Query: 240 LNRKRLEYKQGVDHIF---------SDNHEKDVTTWHQ----IEIDIPRTNPHIPLYQFE 286
R +L+ KQ D F S EK + IE D+ RT+ Y+ +
Sbjct: 355 --RTQLQ-KQKTDEYFRMKLQWKSISQEQEKRNSRLRDYRSLIEKDVNRTDRTNKFYEGQ 411
Query: 287 SVHNS--LKRILYFWAIRHPASGYVQGINDLVTPFFQVFLSEYLSPSAKDDVYSLDPLTY 344
L IL + + GYVQG++DL++P V
Sbjct: 412 DNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYVM--------------------- 450
Query: 345 LTAEQLSDVEADCFWCLSKLLEQITDYFIHGQPGILKQVKHLSQLVKRIDCDLFSHFESE 404
+ E D FWC + ++Q+ F G+ Q+ LS L++ +D S+ ES+
Sbjct: 451 -------ENEVDAFWCFASYMDQMHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYLESQ 503
Query: 405 HVEFLQFSVRWMNCLLMREFQMSMVIRMWDTYLSE 439
+L F RW+ REF ++R+W+ +E
Sbjct: 504 DSGYLYFCFRWLLIRFKREFSFLDILRLWEVMWTE 538
>At5g52590 [T] KOG2197 Ypt/Rab-specific GTPase-activating protein GYP7 and
related proteins
Length = 338
Score = 73.6 bits (179), Expect = 7e-13
Identities = 76/322 (23%), Positives = 131/322 (40%), Gaps = 88/322 (27%)
Query: 207 KLAWNGIPMVHRPVVWKLLIGYLP--SNLKRQEQVLNRKRLEY---KQGVDHIFSDNHEK 261
++ + GI R VW L+GY S +E + + KR+EY KQ I S K
Sbjct: 34 RVFYGGIEHQLRREVWPFLLGYYAYDSTYAEREYLRSVKRMEYATLKQQWQSI-SPEQAK 92
Query: 262 DVTTWHQ----IEIDIPRTNPHIPLYQFE-SVH-NSLKRILYFWAIRHPASGYVQGINDL 315
T + + I+ D+ RT+ Y+ + ++H NS++ IL ++ + GY QG++D
Sbjct: 93 RFTKYRERKGLIDKDVVRTDRAFEYYEGDDNLHVNSMRDILLTYSFYNFDLGYCQGMSDY 152
Query: 316 VTPFFQVFLSEYLSPSAKDDVYSLDPLTYLTAEQLSDVEADCFWCLSKLLEQITDYFIHG 375
++P V + E++ FWC L+E++ F
Sbjct: 153 LSPILFVM----------------------------EDESESFWCFVALMERLGPNFNRD 184
Query: 376 QPGILKQVKHLSQLVKRIDCDLFSHFESEHVEFLQFSVRWMNCLLMREFQMSMVIRMWDT 435
Q G+ Q+ LS+LV+ +D L ++F+ F RW+ REF+ +++W+
Sbjct: 185 QNGMHTQLFALSKLVELLDSPLHNYFKENDCLNYFFCFRWILIQFKREFEYEKTMQLWEV 244
Query: 436 ----YLSETSLETSIVSEDLMSDASTSLDXXXXXXXXXXXXXXXXXXXLSEFHVFVCAAF 491
YLSE FH++VC A
Sbjct: 245 MWTHYLSE------------------------------------------HFHLYVCVAV 262
Query: 492 LVKWSDELM--KMDFQEIITFL 511
L + ++M +MDF ++ F+
Sbjct: 263 LKRCRSKIMGEQMDFDTLLKFI 284
>Hs21362084 [T] KOG2197 Ypt/Rab-specific GTPase-activating protein GYP7 and
related proteins
Length = 691
Score = 72.8 bits (177), Expect = 1e-12
Identities = 69/275 (25%), Positives = 117/275 (42%), Gaps = 53/275 (19%)
Query: 182 VRIEKFKKLIKPKDSTTQV-NLPEIRKLAWNG-IPMVHRPVVWKLLIGYLPSNLKRQEQV 239
V +E++ K I DS ++ N+ ++++ + G + R WK L+GY P + ++E
Sbjct: 317 VSLEEWTKNI---DSEGRILNVDNMKQMIFRGGLSHALRKQAWKFLLGYFPWDSTKEE-- 371
Query: 240 LNRKRLEYKQGVDHIF---------SDNHEKDVTTWHQ----IEIDIPRTNPHIPLYQFE 286
R +L+ KQ D F S EK + IE D+ RT+ Y+ +
Sbjct: 372 --RTQLQ-KQKTDEYFRMKLQWKSISQEQEKRNSRLRDYRSLIEKDVNRTDRTNKFYEGQ 428
Query: 287 SVHNS--LKRILYFWAIRHPASGYVQGINDLVTPFFQVFLSEYLSPSAKDDVYSLDPLTY 344
L IL + + GYVQG++DL++P V
Sbjct: 429 DNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYVM--------------------- 467
Query: 345 LTAEQLSDVEADCFWCLSKLLEQITDYFIHGQPGILKQVKHLSQLVKRIDCDLFSHFESE 404
+ E D FWC + ++Q+ F G+ Q+ LS L++ +D S+ ES+
Sbjct: 468 -------ENEVDAFWCFASYMDQMHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYLESQ 520
Query: 405 HVEFLQFSVRWMNCLLMREFQMSMVIRMWDTYLSE 439
+L F RW+ REF ++R+W+ +E
Sbjct: 521 DSGYLYFCFRWLLIRFKREFGFLDILRLWEVMWTE 555
>SPAC1952.17c [R] KOG4567 GTPase-activating protein
Length = 541
Score = 71.2 bits (173), Expect = 4e-12
Identities = 41/152 (26%), Positives = 76/152 (49%), Gaps = 23/152 (15%)
Query: 293 KRILYFWAIRHPASGYVQGINDLVTPFFQVFLSEYLSPSAKDDVYSLDPLTYLTAEQLSD 352
+RIL+ +A +P GYVQG+N+++ P + V + DP T E
Sbjct: 175 ERILFIYAKLNPGIGYVQGMNEILAPLYYVLAT--------------DP----TYENYYL 216
Query: 353 VEADCFWCLSKLLEQITDYFIH-----GQPGILKQVKHLSQLVKRIDCDLFSHFESEHVE 407
E D F+ ++++ Q+ D + GI + ++ +K+ D +L+ + E + +
Sbjct: 217 CECDAFFLFTQMMVQVRDLYEKTLDHDSDHGIHFLMSKFTERLKKYDYELWENLEEKQIH 276
Query: 408 FLQFSVRWMNCLLMREFQMSMVIRMWDTYLSE 439
+S RW CLL +EF + VIR+WD+ +++
Sbjct: 277 PTYYSFRWFTCLLSQEFPLPDVIRLWDSIIAD 308
>Hs22062664 [TR] KOG2224 Uncharacterized conserved protein contains TBC domain
Length = 766
Score = 70.5 bits (171), Expect = 6e-12
Identities = 61/239 (25%), Positives = 103/239 (42%), Gaps = 38/239 (15%)
Query: 206 RKLAWNGIPMVHRPVVWKLLIGYLP--SNLKRQEQVLNRKRLEYKQGVDHIFSDNHEKDV 263
+ + + GI + R VW L+ Y S + +E + +KR EY + S E+
Sbjct: 418 KAIFFGGIDVSIRGEVWPFLLRYYSHESTSEEREALRLQKRKEYSEIQQKRLSMTPEEHR 477
Query: 264 TTWHQIEI----DIPRTNPHIPLYQFESVHN--SLKRILYFWAIRHPASGYVQGINDLVT 317
W ++ D+ RT+ + ++ E N S++RIL +A+ +PA GY QG++DLV
Sbjct: 478 AFWRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRRILLNYAVYNPAVGYSQGMSDLVA 537
Query: 318 PFFQVFLSEYLSPSAKDDVYSLDPLTYLTAEQLSDVEADCFWCLSKLLEQITDYFIHGQP 377
P L+E L E+D FWC L++
Sbjct: 538 PI----LAEVLD------------------------ESDTFWCFVGLMQNTIFVSSPRDE 569
Query: 378 GILKQVKHLSQLVKRIDCDLFSHFESEHVEFLQ--FSVRWMNCLLMREFQMSMVIRMWD 434
+ KQ+ +L +L++ + H S + LQ F RW+ REF + +R+W+
Sbjct: 570 DMEKQLLYLRELLRLTHVRFYQHLVSLGEDGLQMLFCHRWLLLCFKREFPEAEALRIWE 628
>Hs13375952 [T] KOG2197 Ypt/Rab-specific GTPase-activating protein GYP7 and
related proteins
Length = 648
Score = 65.9 bits (159), Expect = 2e-10
Identities = 66/269 (24%), Positives = 111/269 (40%), Gaps = 57/269 (21%)
Query: 185 EKFKKLIKPKDSTTQVNLPEIRKLAWNG--IPMVHRPVVWKLLIGYLP---------SNL 233
E++ + + P+ QV PE++ ++G P + R WK L+GYL +++
Sbjct: 284 EEWARHVGPEGRLQQV--PELKNRIFSGGLSPSLRREA-WKFLLGYLSWEGTAEEHKAHI 340
Query: 234 KRQEQVLNRKRLEYKQGVDHIFSDNHEKDVTTWHQ----IEIDIPRTNPHIPLYQFESVH 289
+++ R +L++K S E+ + H IE D+ RT+ Y E
Sbjct: 341 RKKTDEYFRMKLQWKS-----VSPEQERRNSLLHGYRSLIERDVSRTDRTNKFY--EGPE 393
Query: 290 NS----LKRILYFWAIRHPASGYVQGINDLVTPFFQVFLSEYLSPSAKDDVYSLDPLTYL 345
N L IL + + H GYVQG++DL++P V +E
Sbjct: 394 NPGLGLLNDILLTYCMYHFDLGYVQGMSDLLSPILYVIQNE------------------- 434
Query: 346 TAEQLSDVEADCFWCLSKLLEQITDYFIHGQPGILKQVKHLSQLVKRIDCDLFSHFESEH 405
D FWC +E + F Q + +Q+ L L++ +D L +S+
Sbjct: 435 ---------VDAFWCFCGFMELVQGNFEESQETMKRQLGRLLLLLRVLDPLLCDFLDSQD 485
Query: 406 VEFLQFSVRWMNCLLMREFQMSMVIRMWD 434
L F RW+ REF V+R+W+
Sbjct: 486 SGSLCFCFRWLLIWFKREFPFPDVLRLWE 514
>CE28983 [R] KOG1102 Rab6 GTPase activator GAPCenA and related TBC domain
proteins
Length = 1005
Score = 65.5 bits (158), Expect = 2e-10
Identities = 57/239 (23%), Positives = 102/239 (41%), Gaps = 55/239 (23%)
Query: 210 WNGIPMVHRPVVWKLLIGYLPSNLKRQE---QVLNRKRLEYKQGVDHIFSDNHEKDVTTW 266
W GIP R V+W L+G +R++ ++L R RL KD+
Sbjct: 510 WKGIPEKLRIVIWPRLLGAERLKHERRDVYAELLLRARLV-------------SKDIK-- 554
Query: 267 HQIEIDIPRT-NPHIPLYQ-FESVHNSLKRILYFWAIRHPASGYVQGINDLVTPFFQVFL 324
QI++DI RT H+ + ++ SL +L +++ + GY QG++ + F
Sbjct: 555 -QIDLDINRTYRDHLAFRKRYDVKQKSLLNVLAAYSMFNTEVGYCQGMSQIAALF----- 608
Query: 325 SEYLSPSAKDDVYSLDPLTYLTAEQLSDVEADCFWCLSKLL----EQITDYFIHGQPGIL 380
L YL E D FW L +L+ + +F+ G P +
Sbjct: 609 -----------------LMYLDEE-------DAFWSLHQLMVSPKHTMHGFFVPGFPKLQ 644
Query: 381 KQVKHLSQLVKRIDCDLFSHFESEHVEFLQFSVRWMNCLLMREFQMSMVIRMWDTYLSE 439
+ +H +++K+ ++ H E + + ++ + W C L R S+ +R+WD +L E
Sbjct: 645 RYEEHFKRVLKKYKPRVYKHLEKQDIPYIYLTKWWFGCFLDR-VPFSLALRLWDVFLVE 702
>7296240 [T] KOG2197 Ypt/Rab-specific GTPase-activating protein GYP7 and
related proteins
Length = 715
Score = 64.7 bits (156), Expect = 3e-10
Identities = 54/233 (23%), Positives = 96/233 (41%), Gaps = 38/233 (16%)
Query: 212 GIPMVHRPVVWKLLIGYLPSNLKRQEQVLNRKR--LEYKQGVDH--IFSDNHEKDVTTWH 267
G+ RP VWK L+ Y + E++ RK+ +EY + E + +
Sbjct: 372 GVVQSLRPEVWKFLLNYYLWSDTHVERIERRKQKSIEYYNMKAQWLAMTTTQEANFCGYR 431
Query: 268 ----QIEIDIPRTNPHIPLYQFESVHNS--LKRILYFWAIRHPASGYVQGINDLVTPFFQ 321
QIE D+ RT+ + + E N L+ IL + + + GYVQG++DL+ P +
Sbjct: 432 ERKCQIEKDVKRTDRSLQFFAGEDNPNLTLLQGILMTYVMYNFDLGYVQGMSDLLAPILE 491
Query: 322 VFLSEYLSPSAKDDVYSLDPLTYLTAEQLSDVEADCFWCLSKLLEQITDYFIHGQPGILK 381
+ ++E D FWC +E + F Q G+
Sbjct: 492 IQVNE----------------------------VDTFWCFVGFMELVFTNFDIDQAGMKT 523
Query: 382 QVKHLSQLVKRIDCDLFSHFESEHVEFLQFSVRWMNCLLMREFQMSMVIRMWD 434
Q + +L++ + LF++ S + + F RW+ RE V+++W+
Sbjct: 524 QFAQIRRLIEFANAPLFNYMRSHDSDNMYFCFRWLLVWYKRELNSEDVLKLWE 576
>7299738 [U] KOG1091 Ypt/Rab-specific GTPase-activating protein GYP6
Length = 654
Score = 62.0 bits (149), Expect = 2e-09
Identities = 64/305 (20%), Positives = 124/305 (39%), Gaps = 67/305 (21%)
Query: 218 RPVVWKLLIGYLPSNLKRQEQVLNRKRLEYKQGVDHIFSDNHEKDV------------TT 265
R V W LL+ L S + ++R+ Y + + H+ V +
Sbjct: 77 RSVHWALLLRVLTSEHRSWTSQRLQQRVRYDKFRADYVRNPHQLAVDCNDDPLSQSTQSV 136
Query: 266 WHQ----------IEIDIPRTNPHIPLYQFESVHNSLKRILYFWAIRHPASGYVQGINDL 315
W+Q I D+ RT P + ++ V N++ IL+++A HP Y QG++++
Sbjct: 137 WNQYFSDQDLFAVIRQDVVRTFPGVDFFRKPLVQNAMVNILFYYAREHPYMCYRQGMHEI 196
Query: 316 VTPFFQVFLSE-----YLSPSAKDDVYSLDPLTYLTAEQLSDVEADCFWCLSKLLEQITD 370
+ P V S+ + S AK D+ T L + +EAD + S+L+ +
Sbjct: 197 LAPIIFVVYSDHQSLLHFSELAKTDINP----TLLDVLDPAYLEADTYSLFSRLMASVES 252
Query: 371 YF----IHGQPG--------------------ILKQVKHL-SQLVKRIDCDLFSHFESEH 405
Y+ + PG ++ Q+ + +++ + D L + +
Sbjct: 253 YYRVSNLVSTPGGHIEQRAESPGDNETSTEAEVIGQLNFIRDKILAKQDQHLHHYLQKME 312
Query: 406 VEFLQFSVRWMNCLLMREFQMSMVIRMWDTYLSET-----------SLETSIVSEDLMSD 454
+ F +RW+ L REF + ++ +WD +++ ++ I + L+SD
Sbjct: 313 IPLHIFGIRWLRLLFGREFMLLDLLLLWDAIFADSDRFDLPNYILVAMLVHIRDKLLLSD 372
Query: 455 ASTSL 459
+TSL
Sbjct: 373 YTTSL 377
>Hs22056446 [U] KOG2058 Ypt/Rab GTPase activating protein
Length = 788
Score = 61.2 bits (147), Expect = 4e-09
Identities = 59/241 (24%), Positives = 91/241 (37%), Gaps = 42/241 (17%)
Query: 203 PEIRKLAWNGIPMVHRPVVWKLLIGYLPSNLKRQEQVLNRKRLEYKQGVDHIFSDNHEKD 262
PE++ L GIP HR VWK + K + + + L K EK
Sbjct: 527 PELKNLIRAGIPHEHRSKVWKWCVDRHTRKFKDNTEPGHFQTLLQKA---------LEKQ 577
Query: 263 VTTWHQIEIDIPRTNPHIPLYQFESVHN--SLKRILYFWAIRHPASGYVQGINDLVTPFF 320
QIE+D+ RT P+ Y + L+ +L ++ R+P GY QG+N LV
Sbjct: 578 NPASKQIELDLLRTLPNNKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQGLNRLVAV-- 635
Query: 321 QVFLSEYLSPSAKDDVYSLDPLTYLTAEQLSDVEADCFWCLSKLLEQIT--DYFIHGQPG 378
L YL E D FWCL ++E DY+ G
Sbjct: 636 --------------------ALLYLEQE-------DAFWCLVTIVEVFMPRDYYTKTLLG 668
Query: 379 ILKQVKHLSQLVKRIDCDLFSHFESEHVEFLQFSVRWMNCLLMREFQMSMVIRMWDTYLS 438
+ L+ L HFE V++ + W + + ++ ++WD++L
Sbjct: 669 SQVDQRVFRDLMSEKLPRLHGHFEQYKVDYTLITFNWFLVVFVDSVVSDILFKIWDSFLY 728
Query: 439 E 439
E
Sbjct: 729 E 729
>Hs14916463 [R] KOG1093 Predicted protein kinase (contains TBC and RHOD
domains)
Length = 822
Score = 59.3 bits (142), Expect = 1e-08
Identities = 67/304 (22%), Positives = 122/304 (40%), Gaps = 69/304 (22%)
Query: 144 MDSYQGTIPNLNRTISNDLKLQYQIEV---EKDVQ-ELNSLMVRIEKFKKLIKPKDSTTQ 199
++ Q +P+ N +N+L + + EKD + +LN RI F +L+K
Sbjct: 333 LEDDQSNLPHSNS--NNELSAAATLPLIIREKDTEYQLN----RIILFDRLLKAYPYKKN 386
Query: 200 VNLPEIRKLAWNGIPMVHRPVVWKLLIGYLPSNLKRQEQVLNRKRLEYKQGVDHIFSDNH 259
+I K A IP + R + W L+G +G H D
Sbjct: 387 ----QIWKEARVDIPPLMRGLTWAALLGV--------------------EGAIHAKYDAI 422
Query: 260 EKD--VTTWHQIEIDIPRTNPHIPLYQFESVHNSLKRILYFWAIRHPASGYVQGINDLVT 317
+KD + T QIE+DIPR + + L H +R+L W + HP Y QG++ L
Sbjct: 423 DKDTPIPTDRQIEVDIPRCHQYDELLSSPEGHAKFRRVLKAWVVSHPDLVYWQGLDSLCA 482
Query: 318 PFFQVFLSEYLSPSAKDDVYSLDPLTYLTAEQLSDVEADCFWCLSKLL-EQITDYFIHGQ 376
PF + + EA + C+S + + + ++F+
Sbjct: 483 PFLYLNFNN---------------------------EALAYACMSAFIPKYLYNFFLKDN 515
Query: 377 PGILKQ-VKHLSQLVKRIDCDLFSHFESEHVEFLQ--FSVRWMNCLLMREFQMSMVIRMW 433
++++ + SQ++ D +L +H + F+ +++ W + F + + +W
Sbjct: 516 SHVIQEYLTVFSQMIAFHDPELSNHL--NEIGFIPDLYAIPWFLTMFTHVFPLHKIFHLW 573
Query: 434 DTYL 437
DT L
Sbjct: 574 DTLL 577
>CE14882 [T] KOG2197 Ypt/Rab-specific GTPase-activating protein GYP7 and
related proteins
Length = 619
Score = 57.4 bits (137), Expect = 5e-08
Identities = 46/171 (26%), Positives = 70/171 (40%), Gaps = 30/171 (17%)
Query: 270 EIDIPRTNPHIPLYQFESVHN--SLKRILYFWAIRHPASGYVQGINDLVTPFFQVFLSEY 327
E D+ RT+ +P +Q + N L +L + + + GYVQG++D +P V
Sbjct: 10 EKDVARTDRTVPFFQGDDNVNLVHLHNVLMTYVMYNFDLGYVQGMSDFASPLLFVM---- 65
Query: 328 LSPSAKDDVYSLDPLTYLTAEQLSDVEADCFWCLSKLLEQITDYFIHGQPGILKQVKHLS 387
KD+V D FWC L+E F Q I Q+ L
Sbjct: 66 -----KDEV-------------------DTFWCFVGLMELTQKNFETDQAFIKLQMNQLR 101
Query: 388 QLVKRIDCDLFSHFESEHVEFLQFSVRWMNCLLMREFQMSMVIRMWDTYLS 438
LV I+ L ++ ESE + + F RW+ REF ++W+ S
Sbjct: 102 DLVMIINPKLANYLESEKSDDMYFCFRWVLVWFKREFSFLDTCKLWEVLWS 152
>At5g54780 [T] KOG2197 Ypt/Rab-specific GTPase-activating protein GYP7 and
related proteins
Length = 435
Score = 56.2 bits (134), Expect = 1e-07
Identities = 43/172 (25%), Positives = 70/172 (40%), Gaps = 30/172 (17%)
Query: 265 TWHQIEIDIPRTNPHIPLYQFESVHNSLKRILYFWAIRHPASGYVQGINDLVTPFFQVFL 324
T HQI +D+ RT+ + Y+ + + L IL +A GY QG++DL +P
Sbjct: 170 TLHQIGLDVNRTDRTLVFYEKKENLSKLWDILALYAWIDNDVGYCQGMSDLCSPMIM--- 226
Query: 325 SEYLSPSAKDDVYSLDPLTYLTAEQLSDVEADCFWCLSKLLEQITDYF--IHGQPGILKQ 382
L + EAD FWC +L+ ++ F G+ Q
Sbjct: 227 -------------------------LLEDEADAFWCFERLMRRLRGNFRDTGRSVGVEAQ 261
Query: 383 VKHLSQLVKRIDCDLFSHFESEHVEFLQFSVRWMNCLLMREFQMSMVIRMWD 434
+ HL+ + + ID L H E F++R + REF + +W+
Sbjct: 262 LTHLASITQIIDPKLHHHLEKLGGGDYLFAIRMIMVQFRREFSFCDSLYLWE 313
>At5g24390 [T] KOG2197 Ypt/Rab-specific GTPase-activating protein GYP7 and
related proteins
Length = 528
Score = 55.5 bits (132), Expect = 2e-07
Identities = 32/143 (22%), Positives = 58/143 (40%), Gaps = 28/143 (19%)
Query: 292 LKRILYFWAIRHPASGYVQGINDLVTPFFQVFLSEYLSPSAKDDVYSLDPLTYLTAEQLS 351
L +L +A+ P GY QG++DL++P V +Y
Sbjct: 319 LVAVLEAYALHDPEIGYCQGMSDLLSPILSVIPDDY------------------------ 354
Query: 352 DVEADCFWCLSKLLEQITDYFIHGQPGILKQVKHLSQLVKRIDCDLFSHFESEHVEFLQF 411
+ FWC +++ F + GI +Q+ +S+++K D L+ H E E F
Sbjct: 355 ----EAFWCFVGFMKKARQNFRVDEVGITRQLNIVSKIIKSKDSQLYKHLEKVKAEDCFF 410
Query: 412 SVRWMNCLLMREFQMSMVIRMWD 434
R + + RE + + +W+
Sbjct: 411 VYRMVLVMFRRELTLEQTLHLWE 433
>CE29383 [TR] KOG2224 Uncharacterized conserved protein contains TBC domain
Length = 759
Score = 54.3 bits (129), Expect = 5e-07
Identities = 49/228 (21%), Positives = 99/228 (42%), Gaps = 39/228 (17%)
Query: 218 RPVVWKLLIGYLP--SNLKRQEQVLNRKRLEY---KQGVDHIFSDNHEKDVTTWHQIEID 272
R VW L+ P S+ ++E + N LEY ++ + + + ++ + I D
Sbjct: 451 REKVWPFLLRVYPWESSADQRENIKNDLFLEYQNIRKRRYRVTENAQARWISIENSIVKD 510
Query: 273 IPRTNPHIPLYQFESVHNS--LKRILYFWAIRHPASGYVQGINDLVTPFFQVFLSEYLSP 330
+ RT+ P + ++ NS +K IL +A+ +P Y+QG++DL+ P L
Sbjct: 511 VVRTDRKNPFFAGDNNPNSEIMKNILLNYAVMYPDINYIQGMSDLLAP---------LLS 561
Query: 331 SAKDDVYSLDPLTYLTAEQLSDVEADCFWCLSKLLEQ-ITDYFIHGQPGILK-QVKHLSQ 388
+ KD+V D ++C ++Q + G +++ + +L
Sbjct: 562 TLKDEV-------------------DSYFCFKNFMQQTVFSSTPQGNENLMETNLTYLRN 602
Query: 389 LVKRIDCDLFSHFESEHVEFLQ--FSVRWMNCLLMREFQMSMVIRMWD 434
+++ D + H E + + +Q F RW+ REF + + +W+
Sbjct: 603 MLRMFVPDFYEHLEKQRPDAMQLMFVHRWILLCFKREFPENYALHIWE 650
>Hs7661998 [U] KOG1091 Ypt/Rab-specific GTPase-activating protein GYP6
Length = 795
Score = 53.1 bits (126), Expect = 1e-06
Identities = 52/204 (25%), Positives = 88/204 (42%), Gaps = 41/204 (20%)
Query: 269 IEIDIPRTNPHIPLYQFESVHNSLKRILYFWAIRHPASGYVQGINDLVTPFF-------Q 321
IE D+ RT P + +Q E+V L +L+ +A + Y QG+++L+ P Q
Sbjct: 163 IEQDVKRTFPEMQFFQQENVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCDHQ 222
Query: 322 VFLSEYLSPSAKDDVYSLDPLTYLTAEQLSDVEADCFWCLSKLLEQITDYFI----HGQP 377
FL + S SA+ S + T L E L E D + S+L+E +F GQ
Sbjct: 223 AFL--HASESAQP---SEEMKTVLNPEYL---EHDAYAVFSQLMETAEPWFSTFEHDGQK 274
Query: 378 G---------------------ILKQVKHLSQ-LVKRIDCDLFSHFESEHVEFLQFSVRW 415
G I+ +V + L+K+ D +L+ H + + +RW
Sbjct: 275 GKETLMTPIPFARPQDLGPTIAIVTKVNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRW 334
Query: 416 MNCLLMREFQMSMVIRMWDTYLSE 439
+ L REF + ++ +WD ++
Sbjct: 335 VRLLFGREFPLQDLLVVWDALFAD 358
>7290543 [R] KOG1093 Predicted protein kinase (contains TBC and RHOD
domains)
Length = 840
Score = 53.1 bits (126), Expect = 1e-06
Identities = 57/267 (21%), Positives = 110/267 (40%), Gaps = 58/267 (21%)
Query: 171 EKDVQELNSLMVRIEKFKKLIKPKDSTTQVNLPEIRKLAWNGIPMVHRPVVWKLLIGYLP 230
EKD++ R+ F +L++ T + ++++ A +P + R +W L+ +P
Sbjct: 397 EKDIEYQ---FQRVRLFARLLQGYPHTAE----QLQREAAVDVPPLLRGPIWAALLEVVP 449
Query: 231 SNLKRQEQVLNRKRLEYKQGVDHIFSDNHEKDVTTWHQIEIDIPRTNPHIPLYQFESVHN 290
+ + +D S + ++ QIE+DIPR + + L H
Sbjct: 450 NGSYAK--------------IDKFTSTSTDR------QIEVDIPRCHQYDELLSSPDGHR 489
Query: 291 SLKRILYFWAIRHPASGYVQGINDLVTPFFQVFLSEYLSPSAKDDVYSLDPLTYLTAEQL 350
L+R+L W HP Y QG++ L PF YL+ ++ + L +L+
Sbjct: 490 KLRRLLKAWVTAHPQYVYWQGLDSLTAPFL------YLN-------FNNEELAFLS---- 532
Query: 351 SDVEADCFWCLSKLLEQITDYFIHGQPGILKQ-VKHLSQLVKRIDCDLFSHFESEHVEFL 409
F + K L+ +F+ ++K+ + SQL + L H S + F+
Sbjct: 533 ------LFKFIPKYLQW---FFLKDNSAVIKEYLSKFSQLTAFHEPLLAQHLAS--ISFI 581
Query: 410 Q--FSVRWMNCLLMREFQMSMVIRMWD 434
F++ W + F + ++ +WD
Sbjct: 582 PELFAIPWFLTMFSHVFPLHKILHLWD 608
>At5g41940 [T] KOG2197 Ypt/Rab-specific GTPase-activating protein GYP7 and
related proteins
Length = 506
Score = 52.0 bits (123), Expect = 2e-06
Identities = 37/153 (24%), Positives = 64/153 (41%), Gaps = 29/153 (18%)
Query: 295 ILYFWAIRHPASGYVQGINDLVTPFFQVFLSEYLSPSAKDDVYSLDPLTYLTAEQLSDVE 354
IL +A+ P GY QG++DL++P V +DDV +
Sbjct: 307 ILEAYAVYDPEIGYCQGMSDLLSPLIAVM---------EDDVLA---------------- 341
Query: 355 ADCFWCLSKLLEQITDYFIHGQPGILKQVKHLSQLVKRIDCDLFSHFESEHVEFLQFSVR 414
FWC + + F + GI +Q+ +S+++K D L+ H E+ E F R
Sbjct: 342 ---FWCFVGFMSKARHNFRLDEVGIRRQLSMVSKIIKFKDIHLYRHLENLEAEDCFFVYR 398
Query: 415 WMNCLLMREFQMSMVIRMWDT-YLSETSLETSI 446
+ L RE + +W+ + + ++ T I
Sbjct: 399 MVVVLFRRELTFEQTLCLWEVMWADQAAIRTGI 431
>SPCC1259.11c [R] KOG4347 GTPase-activating protein VRP
Length = 720
Score = 51.2 bits (121), Expect = 4e-06
Identities = 50/236 (21%), Positives = 93/236 (39%), Gaps = 42/236 (17%)
Query: 200 VNLPEIRKLAWNGIPMVHRPVVWKLLIGYLPSNLKRQEQVLNRKRLEYKQGVDHIFSDNH 259
+ P +KL +GIP R +W+ G L K + Y + +D + ++
Sbjct: 204 IQTPNFQKLVQSGIPNNLRADIWETCSGSLFPRWKSKGF--------YAKNIDSVINNRC 255
Query: 260 EKDVTTWHQIEIDIPRTNPHIPLYQFESVHNSLKRILYFWAIRHPASGYVQGINDLVTPF 319
E +IE D+ R+ P P YQ + N+L+RIL F++ + GY Q +N ++
Sbjct: 256 EYS----EEIEKDLTRSLPDYPAYQSPTGINTLRRILLFYSETNKEVGYCQAMNIVLAAL 311
Query: 320 FQVFLSEYLSPSAKDDVYSLDPLTYLTAEQLSDVEADCFWCLSKLLE-QITDYFIHGQPG 378
L Y T EQ ++ S+L E I Y+ G
Sbjct: 312 ----------------------LVYCTEEQ-------AYFLFSQLCEFYIPGYYAKIIHG 342
Query: 379 ILKQVKHLSQLVKRIDCDLFSHFESEHVEFLQFSVRWMNCLLMREFQMSMVIRMWD 434
+L + +++ L+ ++ ++ W L +++F++ R+ D
Sbjct: 343 LLLDLTVFEYVLEHTLPHLYQKIIELDMDLKLITINWFFSLFIKDFRLDYAFRILD 398
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.319 0.134 0.403
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,019,237
Number of Sequences: 60738
Number of extensions: 1220767
Number of successful extensions: 3395
Number of sequences better than 1.0e-05: 34
Number of HSP's better than 0.0 without gapping: 11
Number of HSP's successfully gapped in prelim test: 23
Number of HSP's that attempted gapping in prelim test: 3298
Number of HSP's gapped (non-prelim): 63
length of query: 546
length of database: 30,389,216
effective HSP length: 111
effective length of query: 435
effective length of database: 23,647,298
effective search space: 10286574630
effective search space used: 10286574630
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)