ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactI2177 check: MH S KOG1843 Function unknown Uncharacterized conserved protein
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactI2177 740411 739095 -439
(439 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YFR024c-a [S] KOG1843 Uncharacterized conserved protein 407 e-113
YHR016c [S] KOG1843 Uncharacterized conserved protein 388 e-107
YFR024c [S] KOG1843 Uncharacterized conserved protein 313 3e-85
SPAPJ696.02 [S] KOG1843 Uncharacterized conserved protein 292 6e-79
At3g43230 [S] KOG1843 Uncharacterized conserved protein 132 8e-31
At1g29800 [S] KOG1843 Uncharacterized conserved protein 115 1e-25
Hs7661670 [S] KOG1843 Uncharacterized conserved protein 101 2e-21
SPBC21D10.12 [U] KOG3771 Amphiphysin 71 4e-12
YDR388w [U] KOG3771 Amphiphysin 67 4e-11
Hs4504797_1 [TU] KOG1029 Endocytic adaptor protein intersectin 65 2e-10
SPBC119.05c [T] KOG3601 Adaptor protein GRB2 contains SH2 and SH... 64 3e-10
CE23342 [TU] KOG1029 Endocytic adaptor protein intersectin 60 5e-09
CE01784 [T] KOG3601 Adaptor protein GRB2 contains SH2 and SH3 do... 60 5e-09
7303308 [T] KOG3601 Adaptor protein GRB2 contains SH2 and SH3 do... 60 8e-09
Hs20533142 [O] KOG2177 Predicted E3 ubiquitin ligase 59 1e-08
Hs4826844 [Z] KOG0162 Myosin class I heavy chain 58 2e-08
Hs22043851 [T] KOG4225 Sorbin and SH3 domain-containing protein 58 3e-08
Hs11321634 [T] KOG4348 Adaptor protein CMS/SETA 58 3e-08
CE10236 [TR] KOG2222 Uncharacterized conserved protein contains ... 58 3e-08
Hs20544596 [TU] KOG1029 Endocytic adaptor protein intersectin 57 5e-08
7298751 [TU] KOG1029 Endocytic adaptor protein intersectin 57 5e-08
Hs22051526 [Z] KOG0162 Myosin class I heavy chain 57 7e-08
Hs20533984 [T] KOG4225 Sorbin and SH3 domain-containing protein 56 1e-07
Hs20546302 [O] KOG2177 Predicted E3 ubiquitin ligase 55 2e-07
CE18195 [IT] KOG1118 Lysophosphatidic acid acyltransferase endop... 55 2e-07
CE08579 [T] KOG2199 Signal transducing adaptor protein STAM/STAM2 55 2e-07
SPBC1734.08 [T] KOG2199 Signal transducing adaptor protein STAM/... 55 2e-07
Hs19923335 [T] KOG4225 Sorbin and SH3 domain-containing protein 55 2e-07
7302755_2 [S] KOG2995 FOG: SH3 domain 55 2e-07
7300664_2 [TUZ] KOG2856 Adaptor protein PACSIN 55 2e-07
Hs16418431 [R] KOG4429 Uncharacterized conserved protein contain... 54 4e-07
Hs11128045_1 [TU] KOG1029 Endocytic adaptor protein intersectin 54 5e-07
YGR136w [T] KOG3601 Adaptor protein GRB2 contains SH2 and SH3 do... 54 6e-07
Hs4758476 [T] KOG3601 Adaptor protein GRB2 contains SH2 and SH3 ... 54 6e-07
Hs20127477 [TZ] KOG2546 Abl interactor ABI-1 contains SH3 domain 54 6e-07
Hs4885153 [T] KOG4792 Crk family adapters 53 1e-06
Hs4502217 [T] KOG4225 Sorbin and SH3 domain-containing protein 53 1e-06
Hs10947118 [T] KOG4225 Sorbin and SH3 domain-containing protein 53 1e-06
Hs20070146 [IT] KOG1118 Lysophosphatidic acid acyltransferase en... 52 1e-06
Hs5453754 [T] KOG4226 Adaptor protein NCK/Dock contains SH2 and ... 52 2e-06
Hs4506931 [IT] KOG1118 Lysophosphatidic acid acyltransferase end... 52 2e-06
CE29645 [T] KOG4226 Adaptor protein NCK/Dock contains SH2 and SH... 52 2e-06
CE29644 [T] KOG4226 Adaptor protein NCK/Dock contains SH2 and SH... 52 2e-06
7299844 [TZ] KOG2546 Abl interactor ABI-1 contains SH3 domain 52 2e-06
YPR154w [T] KOG3601 Adaptor protein GRB2 contains SH2 and SH3 do... 52 2e-06
YHL002w [T] KOG2199 Signal transducing adaptor protein STAM/STAM2 52 2e-06
Hs4506929 [IT] KOG1118 Lysophosphatidic acid acyltransferase end... 52 2e-06
Hs4504111 [T] KOG3601 Adaptor protein GRB2 contains SH2 and SH3 ... 52 2e-06
Hs11386133 [Z] KOG3565 Cdc42-interacting protein CIP4 52 2e-06
Hs7108367 [T] KOG2996 Rho guanine nucleotide exchange factor VAV3 51 3e-06
Hs4507871 [T] KOG2996 Rho guanine nucleotide exchange factor VAV3 51 3e-06
Hs21361641 [R] KOG0266 WD40 repeat-containing protein 51 4e-06
CE05763 [Z] KOG0162 Myosin class I heavy chain 51 4e-06
7304330 [T] KOG4792 Crk family adapters 50 5e-06
7298672 [F] KOG2070 Guanine nucleotide exchange factor 50 5e-06
Hs5729856 [T] KOG3601 Adaptor protein GRB2 contains SH2 and SH3 ... 50 7e-06
Hs13994242 [T] KOG4348 Adaptor protein CMS/SETA 50 7e-06
HsM7262391 [T] KOG2996 Rho guanine nucleotide exchange factor VAV3 50 9e-06
Hs8400708 [T] KOG4792 Crk family adapters 50 9e-06
Hs8400706 [T] KOG4792 Crk family adapters 50 9e-06
Hs7382493 [C] KOG4773 NADPH oxidase 50 9e-06
Hs4505345 [C] KOG4773 NADPH oxidase 50 9e-06
Hs22065489 [T] KOG4792 Crk family adapters 50 9e-06
Hs21614496 [T] KOG2996 Rho guanine nucleotide exchange factor VAV3 50 9e-06
7303765 [T] KOG4225 Sorbin and SH3 domain-containing protein 50 9e-06
>YFR024c-a [S] KOG1843 Uncharacterized conserved protein
Length = 451
Score = 407 bits (1047), Expect = e-113
Identities = 232/446 (52%), Positives = 263/446 (58%), Gaps = 42/446 (9%)
Query: 33 KAAKVLASFVKPNQVLSANDVIPPEVLKSAKGLAIITVLKAGFLFSGRAGSGVIVARLPD 92
++ K +FVKPNQV A+ VIPP+VLK AKGLAIIT+LKAGFLFSGRAGSGVIVARL D
Sbjct: 9 RSLKSETNFVKPNQVFGADQVIPPDVLKRAKGLAIITILKAGFLFSGRAGSGVIVARLKD 68
Query: 93 GGWSAPSXXXXXXXXXXXXXXLELTDFVFILNTADAVKSFSQFGSITLGGNVSVAAGPLG 152
G WSAPS +ELTDFVFILNT DAVKSFS+FG+ITLGGNVSV+AGPLG
Sbjct: 69 GTWSAPSAIAMAGAGAGGMVGIELTDFVFILNTQDAVKSFSEFGTITLGGNVSVSAGPLG 128
Query: 153 RNXXXXXXXXXXXXXXIFAYSKTKGLFAGVSLEGSVIIERREANRKFYGNNCTAKMILSG 212
R+ +FAYSK+KGLFAGVS+EGS IIERREANRKFYG+NCTAKMILSG
Sbjct: 129 RSAEAAASASAGGVAAVFAYSKSKGLFAGVSVEGSAIIERREANRKFYGDNCTAKMILSG 188
Query: 213 RVRPPPSVDPLFRVLESRAFNYR-SPRXXXXXXXXXXXXXXXXXXXXXIPSSFDSDDLDS 271
R+RPPP+VDPLFRVLESRAFNYR S IPSSF S D S
Sbjct: 189 RIRPPPAVDPLFRVLESRAFNYRPSNGGRGSFDDDEDDYYDDDDYYNDIPSSFSSTDASS 248
Query: 272 QRPNTRSTRRRA------------------------------NXXXXXXXXXXXXXXXXX 301
RPNTRSTRRRA N
Sbjct: 249 TRPNTRSTRRRAQSGSRYTFDDDDDDDDYGTGYSRNSRLAPTNSGGSGGKLDDPSGASSY 308
Query: 302 XXXXXXXXXXXXQGPSSNSRWEDEVY-DLNDRFERTNLNTRNARGGPSRPKSEKPDXXXX 360
+ SS +RW D+ Y D +D +E R G E D
Sbjct: 309 YASHRRSGTAQSRARSSRNRWADDEYDDYDDDYES---GYRRGNGRDRTKDREVDDLSNR 365
Query: 361 XXXXXXXXXXXXANSPAR-------NSGAPKAVALYTFKGEESGDLPFRKGDVISIIKKS 413
S R ++ +PKAVALY+F GEESGDLPFRKGDVI+I+KKS
Sbjct: 366 FSKSRISSASTPQTSQGRFTAPTSPSTSSPKAVALYSFAGEESGDLPFRKGDVITILKKS 425
Query: 414 ESQDDWWTGRVNGKEGIFPANYVELV 439
+SQ+DWWTGRVNG+EGIFPANYVELV
Sbjct: 426 DSQNDWWTGRVNGREGIFPANYVELV 451
>YHR016c [S] KOG1843 Uncharacterized conserved protein
Length = 468
Score = 388 bits (996), Expect = e-107
Identities = 223/452 (49%), Positives = 258/452 (56%), Gaps = 45/452 (9%)
Query: 32 RKAAKVLASFVKPNQVLSANDVIPPEVLKSAKGLAIITVLKAGFLFSGRAGSGVIVARLP 91
+KAAKVL SFVKPNQV A+ VIPP VLK AKGLAIITVLKAGFLFSGRAGSGVIVARL
Sbjct: 16 KKAAKVLRSFVKPNQVFGADQVIPPYVLKRAKGLAIITVLKAGFLFSGRAGSGVIVARLK 75
Query: 92 DGGWSAPSXXXXXXXXXXXXXXLELTDFVFILNTADAVKSFSQFGSITLGGNVSVAAGPL 151
DG WSAPS +ELTDFVFILN+ +AV+SFS+FG+ITLGGNVSV+AGPL
Sbjct: 76 DGTWSAPSAIAMAGAGAGGMVGVELTDFVFILNSEEAVRSFSEFGTITLGGNVSVSAGPL 135
Query: 152 GRNXXXXXXXXXXXXXXIFAYSKTKGLFAGVSLEGSVIIERREANRKFYGNNCTAKMILS 211
GR+ +FAYSK+KGLFAGVS+EGS I+ERREANRKFYG+NCT+KMILS
Sbjct: 136 GRSAEAAASASTGGVSAVFAYSKSKGLFAGVSVEGSAILERREANRKFYGDNCTSKMILS 195
Query: 212 GRVRPPPSVDPLFRVLESRAFNYR-----SPRXXXXXXXXXXXXXXXXXXXXXIPSSFDS 266
GRV+ PP+ DPL R+LESRAFN+ IP SFDS
Sbjct: 196 GRVKVPPAADPLLRILESRAFNFTRHDHDDNASGDDFYDDGQYSDNTSHYYDDIPDSFDS 255
Query: 267 DDLDSQRPNTRSTRRRANXXXXXX-----------------XXXXXXXXXXXXXXXXXXX 309
D S RPNTRS+RRR
Sbjct: 256 TDESSTRPNTRSSRRRGMSLGSRSRYDDDYDDDGYGRGRGYGDFDSEDEDYDYGRSPNRN 315
Query: 310 XXXXQGPS--------SNSRWEDEVYDLNDRFERTNL------NTRNARGGPSR------ 349
+GP +N+RWED++YD + + R N NTR R G R
Sbjct: 316 SSRNRGPQIDRGTKPRANTRWEDDLYDRDTEYSRPNHSGRDYDNTRGNRRGYGRERGYSL 375
Query: 350 ---PKSEKPDXXXXXXXXXXXXXXXXANSPARNSGAPKAVALYTFKGEESGDLPFRKGDV 406
P S A NS P AVALY F GE+ GDL F+KGDV
Sbjct: 376 GHGPTHPSNMSNVDDLSHKMSKTGLGNESTATNSATPTAVALYNFAGEQPGDLAFKKGDV 435
Query: 407 ISIIKKSESQDDWWTGRVNGKEGIFPANYVEL 438
I+I+KKS+SQ+DWWTGR NGKEGIFPANYV +
Sbjct: 436 ITILKKSDSQNDWWTGRTNGKEGIFPANYVRV 467
>YFR024c [S] KOG1843 Uncharacterized conserved protein
Length = 373
Score = 313 bits (802), Expect = 3e-85
Identities = 181/365 (49%), Positives = 206/365 (55%), Gaps = 42/365 (11%)
Query: 114 LELTDFVFILNTADAVKSFSQFGSITLGGNVSVAAGPLGRNXXXXXXXXXXXXXXIFAYS 173
+ELTDFVFILNT DAVKSFS+FG+ITLGGNVSV+AGPLGR+ +FAYS
Sbjct: 12 IELTDFVFILNTQDAVKSFSEFGTITLGGNVSVSAGPLGRSAEAAASASAGGVAAVFAYS 71
Query: 174 KTKGLFAGVSLEGSVIIERREANRKFYGNNCTAKMILSGRVRPPPSVDPLFRVLESRAFN 233
K+KGLFAGVS+EGS IIERREANRKFYG+NCTAKMILSGR+RPPP+VDPLFRVLESRAFN
Sbjct: 72 KSKGLFAGVSVEGSAIIERREANRKFYGDNCTAKMILSGRIRPPPAVDPLFRVLESRAFN 131
Query: 234 YR-SPRXXXXXXXXXXXXXXXXXXXXXIPSSFDSDDLDSQRPNTRSTRRRA--------- 283
YR S IPSSF S D S RPNTRSTRRRA
Sbjct: 132 YRPSNGGRGSFDDDEDDYYDDDDYYNDIPSSFSSTDASSTRPNTRSTRRRAQSGSRYTFD 191
Query: 284 ---------------------NXXXXXXXXXXXXXXXXXXXXXXXXXXXXXQGPSSNSRW 322
N + SS +RW
Sbjct: 192 DDDDDDDYGTGYSRNSRLAPTNSGGSGGKLDDPSGASSYYASHRRSGTAQSRARSSRNRW 251
Query: 323 EDEVY-DLNDRFERTNLNTRNARGGPSRPKSEKPDXXXXXXXXXXXXXXXXANSPAR--- 378
D+ Y D +D +E R G E D S R
Sbjct: 252 ADDEYDDYDDDYES---GYRRGNGRDRTKDREVDDLSNRFSKSRISSASTPQTSQGRFTA 308
Query: 379 ----NSGAPKAVALYTFKGEESGDLPFRKGDVISIIKKSESQDDWWTGRVNGKEGIFPAN 434
++ +PKAVALY+F GEESGDLPFRKGDVI+I+KKS+SQ+DWWTGRVNG+EGIFPAN
Sbjct: 309 PTSPSTSSPKAVALYSFAGEESGDLPFRKGDVITILKKSDSQNDWWTGRVNGREGIFPAN 368
Query: 435 YVELV 439
YVELV
Sbjct: 369 YVELV 373
>SPAPJ696.02 [S] KOG1843 Uncharacterized conserved protein
Length = 430
Score = 292 bits (748), Expect = 6e-79
Identities = 179/445 (40%), Positives = 233/445 (52%), Gaps = 69/445 (15%)
Query: 32 RKAAKVLASFVKPNQVLSANDVIPPEVLKSAKGLAIITVLKAGFLFSGRAGSGVIVARLP 91
+KA K+L SFV P Q L A +VIPP VL +AKGL I+TVLKAGFLFSGR GSG+IVARL
Sbjct: 16 KKAGKILTSFVDPRQTLGAQEVIPPSVLTNAKGLVIMTVLKAGFLFSGRIGSGLIVARLD 75
Query: 92 DGGWSAPSXXXXXXXXXXXXXXLELTDFVFILNTADAVKSFSQFGSITLGGNVSVAAGPL 151
DG WSAPS ELTDFV ILN+ AV++F++ GSITLGGN+S+AAGPL
Sbjct: 76 DGTWSAPSAVMTGGMGVGAQIGSELTDFVIILNSKAAVQTFARLGSITLGGNLSIAAGPL 135
Query: 152 GRNXXXXXXXXXXXXXXIFAYSKTKGLFAGVSLEGSVIIERREANRKFYGNNCTAKMILS 211
GRN +F+YSKTKGLFAGVSLEGSV++ERR+ANR Y + TAK +LS
Sbjct: 136 GRNAEAGGGASVGGMAPMFSYSKTKGLFAGVSLEGSVLVERRDANRSLYRGDITAKRLLS 195
Query: 212 GRVRPPPSVDPLFRVLESRAFNYRSPRXXXXXXXXXXXXXXXXXXXXXIPSSFDSDDLDS 271
G+V P + DPL+RVL S+ FN +P D + D
Sbjct: 196 GQVAQPAAADPLYRVLNSKIFNLN--------------RGDEGDIYNDVPIYADDEPEDI 241
Query: 272 QRPNTRSTRRRANXXXXXXXXXXXXXXXXXXXXXXXXXXXXXQGPSSNSRWEDEVYDLND 331
P+++ST+RR + S+ SR D+ + +
Sbjct: 242 WGPSSKSTKRRDSADRSSSYSRRGDSYR-----------------SNRSRAHDDDDEDDY 284
Query: 332 RFERTNLNTRNARGG-------------------PSRPKS---EKPDXXXXXXXXXXXXX 369
F R+ +R GG P R +S E +
Sbjct: 285 SFSRSKSLSRKTAGGSLRSSKMDNRRSKYADTPSPRRSRSYSDEDEESVYSSDVSTESSS 344
Query: 370 XXXANS-----PAR-----------NSGAPKAVALYTFKGEESGDLPFRKGDVISIIKKS 413
+ S P+R + G +A A+Y+F GE+ GDL F+KGD+I I+++S
Sbjct: 345 QFSSRSSEYSKPSRPTAPKPKFKQDSLGPNQARAMYSFAGEQPGDLSFQKGDIIDIVERS 404
Query: 414 ESQDDWWTGRVNGKEGIFPANYVEL 438
S DDWWTGR+ +EGIFPANYV+L
Sbjct: 405 GSHDDWWTGRIGYREGIFPANYVKL 429
>At3g43230 [S] KOG1843 Uncharacterized conserved protein
Length = 485
Score = 132 bits (333), Expect = 8e-31
Identities = 78/196 (39%), Positives = 105/196 (52%), Gaps = 2/196 (1%)
Query: 33 KAAKVLASFVKPNQVLSANDVIPPEVLKSAKGLAIITVLKAGFLFSGRAGSGVIVARLPD 92
KAA L + + + L IP VL AKGLAIITV KAG L S + G+G++++R PD
Sbjct: 282 KAANTLRGYCQVAR-LDPEKSIPHAVLSRAKGLAIITVAKAGALLSYKLGTGLVISRRPD 340
Query: 93 GGWSAPSXXXXXXXXXXXXXXLELTDFVFILNTADAVKSFSQFGSITLGGNVSVAAGPLG 152
G WSAPS EL DF+ +L+ AVK+F +LG S AAGP+G
Sbjct: 341 GSWSAPSAILSVGLGWGAQIGGELMDFIIVLHDVKAVKTFCSRMHFSLGAGCSAAAGPIG 400
Query: 153 RNXXXXXXXXXXXXXXIFAYSKTKGLFAGVSLEGSVIIERREANRKFYGN-NCTAKMILS 211
R + YS++KG F GVSLEG+++ RR+ N KFYG+ + IL
Sbjct: 401 RVLEADLRAGDKGSGVCYTYSRSKGAFVGVSLEGNLVATRRDMNVKFYGDPYLSTSDILL 460
Query: 212 GRVRPPPSVDPLFRVL 227
G V P + +PL+ L
Sbjct: 461 GMVDQPKAAEPLYTAL 476
>At1g29800 [S] KOG1843 Uncharacterized conserved protein
Length = 510
Score = 115 bits (288), Expect = 1e-25
Identities = 64/196 (32%), Positives = 94/196 (47%), Gaps = 1/196 (0%)
Query: 33 KAAKVLASFVKPNQVLSANDVIPPEVLKSAKGLAIITVLKAGFLFSGRAGSGVIVARLPD 92
KA L ++ IP +L+ AKGLA+ITV + G + + + G+G++VAR D
Sbjct: 292 KATNTLRGYITKVGSSRTERSIPDAILRQAKGLAVITVARVGVMVTYKIGTGLVVARRDD 351
Query: 93 GGWSAPSXXXXXXXXXXXXXXLELTDFVFILNTADAVKSFSQFGSITLGGNVSVAAGPLG 152
G WS PS E DF+ +L T +A+++F + +G +S A G G
Sbjct: 352 GSWSPPSAISSFGLGWGAQAGGEFIDFIIVLRTREAIQTFGSNTHLVVGAGLSAAVGVTG 411
Query: 153 RNXXXXXXXXXXXXXXIFAYSKTKGLFAGVSLEGSVIIERREANRKFYGN-NCTAKMILS 211
R + YS +KG F G SLEGS+ R N +FYG+ + A IL
Sbjct: 412 RAVEADIRAGSGGYAACYTYSCSKGAFVGCSLEGSIFTTRTSENSRFYGSQSLAASDILL 471
Query: 212 GRVRPPPSVDPLFRVL 227
G + PP+ L+R L
Sbjct: 472 GSLPRPPAAAALYRAL 487
>Hs7661670 [S] KOG1843 Uncharacterized conserved protein
Length = 246
Score = 101 bits (252), Expect = 2e-21
Identities = 54/121 (44%), Positives = 75/121 (61%), Gaps = 2/121 (1%)
Query: 116 LTDFVFILNTADAVKSFSQFGSITLGGNVSVAAGPLGRNXXXXXXXXXXXXXXIFAYSKT 175
++D V ILN AV++F++ G++TLGGN++VA GPLGRN +F Y K+
Sbjct: 2 VSDLVIILNYDRAVEAFAKGGNLTLGGNLTVAVGPLGRNLEGNVALRSSAA--VFTYCKS 59
Query: 176 KGLFAGVSLEGSVIIERREANRKFYGNNCTAKMILSGRVRPPPSVDPLFRVLESRAFNYR 235
+GLFAGVSLEGS +IER+E NRKFY + A IL G P + L+ +L+S Y
Sbjct: 60 RGLFAGVSLEGSCLIERKETNRKFYCQDIRAYDILFGDTPRPAQAEDLYEILDSFTEKYE 119
Query: 236 S 236
+
Sbjct: 120 N 120
Score = 70.1 bits (170), Expect = 6e-12
Identities = 28/55 (50%), Positives = 42/55 (75%)
Query: 384 KAVALYTFKGEESGDLPFRKGDVISIIKKSESQDDWWTGRVNGKEGIFPANYVEL 438
+ ALY+F+G++ GDL F+ GD I++I K++S DWW G++ G+ GIFPANYV +
Sbjct: 191 EVTALYSFEGQQPGDLNFQAGDRITVISKTDSHFDWWEGKLRGQTGIFPANYVTM 245
>SPBC21D10.12 [U] KOG3771 Amphiphysin
Length = 466
Score = 70.9 bits (172), Expect = 4e-12
Identities = 29/66 (43%), Positives = 44/66 (65%)
Query: 373 ANSPARNSGAPKAVALYTFKGEESGDLPFRKGDVISIIKKSESQDDWWTGRVNGKEGIFP 432
A +PA A VALY + + +GDL F GD I ++ ++++Q++WW GR+NG +G FP
Sbjct: 400 APAPAAAPAAEHVVALYDYAAQAAGDLSFHAGDRIEVVSRTDNQNEWWIGRLNGAQGQFP 459
Query: 433 ANYVEL 438
NYV+L
Sbjct: 460 GNYVQL 465
>YDR388w [U] KOG3771 Amphiphysin
Length = 482
Score = 67.4 bits (163), Expect = 4e-11
Identities = 28/66 (42%), Positives = 43/66 (64%)
Query: 373 ANSPARNSGAPKAVALYTFKGEESGDLPFRKGDVISIIKKSESQDDWWTGRVNGKEGIFP 432
A + A G ALY ++ + +GDL F G VI I++++ ++WWTGR NG++G+FP
Sbjct: 414 AAAVAAAPGVETVTALYDYQAQAAGDLSFPAGAVIEIVQRTPDVNEWWTGRYNGQQGVFP 473
Query: 433 ANYVEL 438
NYV+L
Sbjct: 474 GNYVQL 479
>Hs4504797_1 [TU] KOG1029 Endocytic adaptor protein intersectin
Length = 1221
Score = 65.1 bits (157), Expect = 2e-10
Identities = 28/53 (52%), Positives = 37/53 (68%), Gaps = 3/53 (5%)
Query: 386 VALYTFKGEESGDLPFRKGDVISIIKKSESQDDWWTGRVNGKEGIFPANYVEL 438
+A+YT++ E GDL F++GDVI + KK DWWTG V K G+FP+NYV L
Sbjct: 1008 IAMYTYESSEQGDLTFQQGDVILVTKKD---GDWWTGTVGDKAGVFPSNYVRL 1057
Score = 56.6 bits (135), Expect = 7e-08
Identities = 21/55 (38%), Positives = 36/55 (65%), Gaps = 2/55 (3%)
Query: 384 KAVALYTFKGEESGDLPFRKGDVISIIKKSESQDDWWTGRVNGKEGIFPANYVEL 438
+ + +Y + + +L F KG +I+++ K + DWW G VNG+ G+FP+NYV+L
Sbjct: 1159 QVIGMYDYTAQNDDELAFNKGQIINVLNKEDP--DWWKGEVNGQVGLFPSNYVKL 1211
Score = 53.1 bits (126), Expect = 8e-07
Identities = 24/56 (42%), Positives = 37/56 (65%), Gaps = 3/56 (5%)
Query: 384 KAVALYTFKGEESGDLPFRKGDVISIIKKSESQDDWWTGRVNGKEGIFPANYVELV 439
+A ALY ++ ++ L F K DVI+++ E QD WW G V G++G FP +YV+L+
Sbjct: 917 QAQALYPWRAKKDNHLNFNKNDVITVL---EQQDMWWFGEVQGQKGWFPKSYVKLI 969
>SPBC119.05c [T] KOG3601 Adaptor protein GRB2 contains SH2 and SH3 domains
Length = 296
Score = 64.3 bits (155), Expect = 3e-10
Identities = 27/56 (48%), Positives = 40/56 (71%), Gaps = 2/56 (3%)
Query: 384 KAVALYTFKGEESGDLPFRKGDVISIIKKSESQDDWWTGRVNGKEGIFPANYVELV 439
+ +A+Y F G ++GDL F G+VI +++ +DWW G +NGKEGIFP+NYV L+
Sbjct: 144 RVLAMYDFPGPDAGDLGFHAGEVIIVLE--HVNNDWWRGELNGKEGIFPSNYVRLL 197
>CE23342 [TU] KOG1029 Endocytic adaptor protein intersectin
Length = 1097
Score = 60.5 bits (145), Expect = 5e-09
Identities = 26/51 (50%), Positives = 36/51 (69%), Gaps = 3/51 (5%)
Query: 388 LYTFKGEESGDLPFRKGDVISIIKKSESQDDWWTGRVNGKEGIFPANYVEL 438
+Y F+ E+ DL GD I +++K+ D+WW GR NG+EGIFPANYVE+
Sbjct: 902 IYDFEAVETTDLALHVGDTILVLEKN---DEWWKGRCNGREGIFPANYVEI 949
Score = 50.1 bits (118), Expect = 7e-06
Identities = 24/61 (39%), Positives = 38/61 (61%), Gaps = 5/61 (8%)
Query: 380 SGAPKAVALYTFKGEESGDLPFRKGDVISIIKKSESQDDWWTGRVN---GKEGIFPANYV 436
S A +A A+Y ++ + +L F+ GDVI + KSE+ +WW+G K G+FP+NYV
Sbjct: 1037 SPATRATAVYDYEASQPDELGFKTGDVIIVTDKSEA--EWWSGHREQDPSKSGLFPSNYV 1094
Query: 437 E 437
+
Sbjct: 1095 Q 1095
>CE01784 [T] KOG3601 Adaptor protein GRB2 contains SH2 and SH3 domains
Length = 228
Score = 60.5 bits (145), Expect = 5e-09
Identities = 25/50 (50%), Positives = 38/50 (76%), Gaps = 2/50 (4%)
Query: 387 ALYTFKGEESGDLPFRKGDVISIIKKSESQDDWWTGRVNGKEGIFPANYV 436
AL+ F +ESG+L F++GDVI++I K + +WW G++N + GIFP+NYV
Sbjct: 161 ALFDFNPQESGELAFKRGDVITLINKDDP--NWWEGQLNNRRGIFPSNYV 208
>7303308 [T] KOG3601 Adaptor protein GRB2 contains SH2 and SH3 domains
Length = 211
Score = 59.7 bits (143), Expect = 8e-09
Identities = 25/50 (50%), Positives = 37/50 (74%), Gaps = 2/50 (4%)
Query: 387 ALYTFKGEESGDLPFRKGDVISIIKKSESQDDWWTGRVNGKEGIFPANYV 436
ALY F +ESG+L FR+GDVI++ +S+ ++WW G + ++GIFPA YV
Sbjct: 159 ALYDFVPQESGELDFRRGDVITVTDRSD--ENWWNGEIGNRKGIFPATYV 206
>Hs20533142 [O] KOG2177 Predicted E3 ubiquitin ligase
Length = 888
Score = 59.3 bits (142), Expect = 1e-08
Identities = 26/57 (45%), Positives = 39/57 (67%), Gaps = 2/57 (3%)
Query: 383 PKAVALYTFKGEESGDLPFRKGDVISIIKKSESQDDWWTGRVNGKEGIFPANYVELV 439
P A ALY ++G+E GDL F KGD+ II + + ++W+ G VNG G FP N+V+++
Sbjct: 137 PCAKALYNYEGKEPGDLKFSKGDI--IILRRQVDENWYHGEVNGIHGFFPTNFVQII 191
>Hs4826844 [Z] KOG0162 Myosin class I heavy chain
Length = 1109
Score = 58.2 bits (139), Expect = 2e-08
Identities = 26/61 (42%), Positives = 36/61 (58%), Gaps = 2/61 (3%)
Query: 376 PARNSGAPKAVALYTFKGEESGDLPFRKGDVISIIKKSESQDDWWTGRVNGKEGIFPANY 435
P P+ ALY + +++ +L F D+I IIK+ S WWTGR+ GK G+FP NY
Sbjct: 1048 PKPKPQVPQCKALYAYDAQDTDELSFNANDIIDIIKEDPS--GWWTGRLRGKPGLFPNNY 1105
Query: 436 V 436
V
Sbjct: 1106 V 1106
>Hs22043851 [T] KOG4225 Sorbin and SH3 domain-containing protein
Length = 790
Score = 57.8 bits (138), Expect = 3e-08
Identities = 25/56 (44%), Positives = 38/56 (67%), Gaps = 2/56 (3%)
Query: 384 KAVALYTFKGEESGDLPFRKGDVISIIKKSESQDDWWTGRVNGKEGIFPANYVELV 439
KA ALY F+GE +L F+ GD+I+ ++ + DDW +G + GK GIFP NY++ +
Sbjct: 734 KAKALYDFRGENEDELSFKAGDIITELESVD--DDWMSGELMGKSGIFPKNYIQFL 787
Score = 54.7 bits (130), Expect = 3e-07
Identities = 24/61 (39%), Positives = 40/61 (65%), Gaps = 2/61 (3%)
Query: 379 NSGAPKAVALYTFKGEESGDLPFRKGDVISIIKKSESQDDWWTGRVNGKEGIFPANYVEL 438
+SGAP AV L+ F E+ DL G+++ +++K ++ DW+ G + GIFPANYV++
Sbjct: 494 DSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDT--DWYRGNCRNQIGIFPANYVKV 551
Query: 439 V 439
+
Sbjct: 552 I 552
Score = 52.0 bits (123), Expect = 2e-06
Identities = 27/64 (42%), Positives = 40/64 (62%), Gaps = 2/64 (3%)
Query: 373 ANSPARNSGAPKAVALYTFKGEESGDLPFRKGDVISIIKKSESQDDWWTGRVNGKEGIFP 432
+NS + A AL++F E S DL F++GD I I+++ +S DW GR+ +EGIFP
Sbjct: 654 SNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDS--DWCRGRLQDREGIFP 711
Query: 433 ANYV 436
A +V
Sbjct: 712 AVFV 715
>Hs11321634 [T] KOG4348 Adaptor protein CMS/SETA
Length = 639
Score = 57.8 bits (138), Expect = 3e-08
Identities = 26/98 (26%), Positives = 43/98 (43%)
Query: 338 LNTRNARGGPSRPKSEKPDXXXXXXXXXXXXXXXXANSPARNSGAPKAVALYTFKGEESG 397
L TR + K EKP ++ + L+ ++G
Sbjct: 227 LRTRTSSSETEEKKPEKPLILQSLGPKTQSVEITKTDTEGKIKAKEYCRTLFAYEGTNED 286
Query: 398 DLPFRKGDVISIIKKSESQDDWWTGRVNGKEGIFPANY 435
+L F++G++I +I K + WW G +NGKEG+FP N+
Sbjct: 287 ELTFKEGEIIHLISKETGEAGWWRGELNGKEGVFPDNF 324
>CE10236 [TR] KOG2222 Uncharacterized conserved protein contains TBC SH3 and
RUN domains
Length = 808
Score = 57.8 bits (138), Expect = 3e-08
Identities = 30/62 (48%), Positives = 38/62 (60%), Gaps = 2/62 (3%)
Query: 378 RNSGAPKAVALYTFKGEESGDLPFRKGDVISIIKKSESQDDWWTGRVNGKEGIFPANYVE 437
R GA +A AL F EE +L FRK D+++II SE + W G VNG G FPA +VE
Sbjct: 522 RRVGAKRARALLDFAREEENELGFRKNDIVTII--SEKDEHCWVGEVNGLRGWFPAKFVE 579
Query: 438 LV 439
+V
Sbjct: 580 VV 581
>Hs20544596 [TU] KOG1029 Endocytic adaptor protein intersectin
Length = 223
Score = 57.0 bits (136), Expect = 5e-08
Identities = 22/55 (40%), Positives = 36/55 (65%), Gaps = 2/55 (3%)
Query: 384 KAVALYTFKGEESGDLPFRKGDVISIIKKSESQDDWWTGRVNGKEGIFPANYVEL 438
+ + +Y + + +L F KG +I+I+ K + DWW G VNG+ G+FP+NYV+L
Sbjct: 162 QVIGMYDYTAQNDDELAFNKGQIINILNKEDP--DWWKGEVNGQVGLFPSNYVKL 214
Score = 52.4 bits (124), Expect = 1e-06
Identities = 27/59 (45%), Positives = 39/59 (65%), Gaps = 6/59 (10%)
Query: 386 VALYTFKGEESGDLPFRKGDVISIIKKSESQDDWWTG--RVNGKE---GIFPANYVELV 439
+A+YT++ E GDL F++GDVI + KK + WW G + GK+ G FPANYV+L+
Sbjct: 82 IAMYTYQSSEQGDLTFQQGDVILVTKKM-NPGGWWEGELQARGKKRQIGWFPANYVKLL 139
>7298751 [TU] KOG1029 Endocytic adaptor protein intersectin
Length = 1097
Score = 57.0 bits (136), Expect = 5e-08
Identities = 23/53 (43%), Positives = 35/53 (65%), Gaps = 2/53 (3%)
Query: 384 KAVALYTFKGEESGDLPFRKGDVISIIKKSESQDDWWTGRVNGKEGIFPANYV 436
K +ALY +K + +L F K D+IS++ + E + WW G +NG G+FP+NYV
Sbjct: 1029 KVIALYPYKAQNDDELSFDKDDIISVLGRDEPE--WWRGELNGLSGLFPSNYV 1079
Score = 55.5 bits (132), Expect = 2e-07
Identities = 21/52 (40%), Positives = 35/52 (66%), Gaps = 3/52 (5%)
Query: 386 VALYTFKGEESGDLPFRKGDVISIIKKSESQDDWWTGRVNGKEGIFPANYVE 437
+A Y ++ E GDL F G+++ +IKK + +WWTG + + G+FP+NYV+
Sbjct: 785 IAAYPYESAEEGDLSFSAGEMVMVIKK---EGEWWTGTIGSRTGMFPSNYVQ 833
>Hs22051526 [Z] KOG0162 Myosin class I heavy chain
Length = 1077
Score = 56.6 bits (135), Expect = 7e-08
Identities = 25/64 (39%), Positives = 39/64 (60%), Gaps = 2/64 (3%)
Query: 376 PARNSGAPKAVALYTFKGEESGDLPFRKGDVISIIKKSESQDDWWTGRVNGKEGIFPANY 435
P + P+ ALY + G++ +L F +VI I+ + S WW GR++G+EG+FP NY
Sbjct: 1016 PQPRTHGPRCRALYQYVGQDVDELSFNVNEVIEILMEDPS--GWWKGRLHGQEGLFPGNY 1073
Query: 436 VELV 439
VE +
Sbjct: 1074 VEKI 1077
>Hs20533984 [T] KOG4225 Sorbin and SH3 domain-containing protein
Length = 141
Score = 55.8 bits (133), Expect = 1e-07
Identities = 23/57 (40%), Positives = 39/57 (68%), Gaps = 2/57 (3%)
Query: 383 PKAVALYTFKGEESGDLPFRKGDVISIIKKSESQDDWWTGRVNGKEGIFPANYVELV 439
P ALY+++G+E GDL F KGD+I + +K + Q W+ G ++G +G PA+Y++ +
Sbjct: 42 PYGKALYSYEGKEPGDLKFNKGDIIVLRRKVDEQ--WYHGELHGTQGFLPASYIQCI 96
>Hs20546302 [O] KOG2177 Predicted E3 ubiquitin ligase
Length = 457
Score = 55.5 bits (132), Expect = 2e-07
Identities = 24/59 (40%), Positives = 39/59 (65%), Gaps = 2/59 (3%)
Query: 381 GAPKAVALYTFKGEESGDLPFRKGDVISIIKKSESQDDWWTGRVNGKEGIFPANYVELV 439
G P+A AL ++G+ GDL F KGD+ I+ + + ++W+ G +NG G FPA+ VE++
Sbjct: 126 GVPRAKALCNYRGQNPGDLRFNKGDI--ILLRRQLDENWYQGEINGISGNFPASSVEVI 182
>CE18195 [IT] KOG1118 Lysophosphatidic acid acyltransferase endophilin/SH3GL
involved in synaptic vesicle formation
Length = 443
Score = 55.5 bits (132), Expect = 2e-07
Identities = 23/64 (35%), Positives = 40/64 (61%), Gaps = 2/64 (3%)
Query: 376 PARNSGAPKAVALYTFKGEESGDLPFRKGDVISIIKKSESQDDWWTGRVNGKEGIFPANY 435
P P+ AL+ F + G+L F++G +I ++ S+ ++W+ GRVNGK G+FP Y
Sbjct: 378 PLSQQQKPQCRALFDFDAQSEGELDFKEGTLIELV--SQIDENWYEGRVNGKTGLFPVTY 435
Query: 436 VELV 439
V+++
Sbjct: 436 VQVL 439
>CE08579 [T] KOG2199 Signal transducing adaptor protein STAM/STAM2
Length = 449
Score = 55.5 bits (132), Expect = 2e-07
Identities = 30/68 (44%), Positives = 43/68 (63%), Gaps = 6/68 (8%)
Query: 373 ANSPA--RNSGAPK--AVALYTFKGEESGDLPFRKGDVISIIKKSESQDDWWTGRVNGKE 428
A+SPA NS P+ ALY F+ ES +L F GD+I+I ES WWTGR+ ++
Sbjct: 200 ASSPAVQTNSNIPEKNVRALYDFEAAESNELSFVAGDIITIT--DESNPHWWTGRIGTQQ 257
Query: 429 GIFPANYV 436
G+FP+++V
Sbjct: 258 GLFPSSFV 265
>SPBC1734.08 [T] KOG2199 Signal transducing adaptor protein STAM/STAM2
Length = 373
Score = 55.1 bits (131), Expect = 2e-07
Identities = 29/67 (43%), Positives = 37/67 (54%), Gaps = 4/67 (5%)
Query: 373 ANSPARNSGAPKAVALYTFKGEESGDLPFRKGDVISIIKKSESQDDWWTGRVNGKEGIFP 432
A SPA S + ALY F E G+L F+KGD+I +++ DWW G GIFP
Sbjct: 210 ATSPA--STVSRVRALYDFAATEQGELSFKKGDIILVLESVYK--DWWKGSCKNAVGIFP 265
Query: 433 ANYVELV 439
NYV+ V
Sbjct: 266 VNYVQRV 272
>Hs19923335 [T] KOG4225 Sorbin and SH3 domain-containing protein
Length = 671
Score = 55.1 bits (131), Expect = 2e-07
Identities = 27/57 (47%), Positives = 42/57 (73%), Gaps = 4/57 (7%)
Query: 384 KAVALYTFKGEESGDLPFRKGDVISIIKKSESQDDWWTGRV--NGKEGIFPANYVEL 438
+AVA YTFKG+ +L FRKG+ I +I+K ++W+ GR+ G++GIFPA+YV++
Sbjct: 458 EAVAQYTFKGDLEVELSFRKGEHICLIRK--VNENWYEGRITGTGRQGIFPASYVQV 512
>7302755_2 [S] KOG2995 FOG: SH3 domain
Length = 701
Score = 55.1 bits (131), Expect = 2e-07
Identities = 26/56 (46%), Positives = 37/56 (65%), Gaps = 2/56 (3%)
Query: 383 PKAVALYTFKGEESGDLPFRKGDVISIIKKSESQDDWWTGRVNGKEGIFPANYVEL 438
P A AL+ F E+ DL F+KGD+I I K ++W+ G+ NG+EG FP NYV++
Sbjct: 1 PHAYALFDFASGEATDLKFKKGDLILI--KHRIDNNWFVGQANGQEGTFPINYVKV 54
>7300664_2 [TUZ] KOG2856 Adaptor protein PACSIN
Length = 481
Score = 55.1 bits (131), Expect = 2e-07
Identities = 24/51 (47%), Positives = 36/51 (70%), Gaps = 1/51 (1%)
Query: 387 ALYTFKGEESGDLPFRKGDVISIIKKSESQDDWWTGRVNGKEGIFPANYVE 437
ALY ++G ES +L F++GDV ++ E + W GR+NG+ G++PANYVE
Sbjct: 430 ALYDYEGAESDELTFKQGDVFEKLE-DEDEQGWCKGRMNGRVGLYPANYVE 479
>Hs16418431 [R] KOG4429 Uncharacterized conserved protein contains SH3 and FCH
domains
Length = 428
Score = 54.3 bits (129), Expect = 4e-07
Identities = 28/72 (38%), Positives = 42/72 (57%), Gaps = 10/72 (13%)
Query: 374 NSPARNSGAPKAV--------ALYTFKGEESGDLPFRKGDVISIIKKSESQDDWWTGRVN 425
++P ++ AP A ALY+F+ + +L KGD++ I +K E + WW G +N
Sbjct: 346 SNPGSSTPAPGAAQLSSRLCKALYSFQARQDDELNLEKGDIVIIHEKKE--EGWWFGSLN 403
Query: 426 GKEGIFPANYVE 437
GK+G FPA YVE
Sbjct: 404 GKKGHFPAAYVE 415
>Hs11128045_1 [TU] KOG1029 Endocytic adaptor protein intersectin
Length = 1177
Score = 53.9 bits (128), Expect = 5e-07
Identities = 20/55 (36%), Positives = 35/55 (63%), Gaps = 2/55 (3%)
Query: 384 KAVALYTFKGEESGDLPFRKGDVISIIKKSESQDDWWTGRVNGKEGIFPANYVEL 438
+ +A+Y + +L F KG +I+++ K + DWW G +NG G+FP+NYV++
Sbjct: 1115 QVIAMYDYAANNEDELSFSKGQLINVMNKDDP--DWWQGEINGVTGLFPSNYVKM 1167
Score = 52.4 bits (124), Expect = 1e-06
Identities = 22/52 (42%), Positives = 33/52 (63%), Gaps = 3/52 (5%)
Query: 386 VALYTFKGEESGDLPFRKGDVISIIKKSESQDDWWTGRVNGKEGIFPANYVE 437
+ALY + E GDL F +G+ I + +K +WWTG + + GIFP+NYV+
Sbjct: 971 IALYPYSSVEPGDLTFTEGEEILVTQKD---GEWWTGSIGDRSGIFPSNYVK 1019
>YGR136w [T] KOG3601 Adaptor protein GRB2 contains SH2 and SH3 domains
Length = 241
Score = 53.5 bits (127), Expect = 6e-07
Identities = 24/51 (47%), Positives = 34/51 (66%), Gaps = 2/51 (3%)
Query: 387 ALYTFKGEESGDLPFRKGDVISIIKKSESQDDWWTGRVNGKEGIFPANYVE 437
ALY F+ ++ GDL + GD I +++K DW+ G+ N K GIFPANYV+
Sbjct: 60 ALYDFEAQQDGDLSLKTGDKIQVLEKISP--DWYRGKSNNKIGIFPANYVK 108
>Hs4758476 [T] KOG3601 Adaptor protein GRB2 contains SH2 and SH3 domains
Length = 330
Score = 53.5 bits (127), Expect = 6e-07
Identities = 24/52 (46%), Positives = 33/52 (63%), Gaps = 2/52 (3%)
Query: 385 AVALYTFKGEESGDLPFRKGDVISIIKKSESQDDWWTGRVNGKEGIFPANYV 436
A ALY F+ E +L F G+V+ ++ S WWTGR++ K G+FPANYV
Sbjct: 276 ARALYDFEALEDDELGFHSGEVVEVL--DSSNPSWWTGRLHNKLGLFPANYV 325
>Hs20127477 [TZ] KOG2546 Abl interactor ABI-1 contains SH3 domain
Length = 475
Score = 53.5 bits (127), Expect = 6e-07
Identities = 25/63 (39%), Positives = 40/63 (62%), Gaps = 2/63 (3%)
Query: 377 ARNSGAPKAVALYTFKGEESGDLPFRKGDVISIIKKSESQDDWWTGRVNGKEGIFPANYV 436
A S K VA+Y + ++ +L F++G +I +IKK++ D W+ G +NG G+FP NYV
Sbjct: 410 APRSYLEKVVAIYDYTKDKEDELSFQEGAIIYVIKKND--DGWYEGVMNGVTGLFPGNYV 467
Query: 437 ELV 439
E +
Sbjct: 468 ESI 470
>Hs4885153 [T] KOG4792 Crk family adapters
Length = 303
Score = 52.8 bits (125), Expect = 1e-06
Identities = 26/65 (40%), Positives = 37/65 (56%), Gaps = 3/65 (4%)
Query: 374 NSPARNSGAPKAVALYTFKGEESGDLPFRKGDVISIIKKSESQDDWWTGR-VNGKEGIFP 432
N P LY F G ++ DLPF+KG+++ II+K E Q WW+ R +G+ G+ P
Sbjct: 117 NLPTAEDNLEYVRTLYDFPGNDAEDLPFKKGEILVIIEKPEEQ--WWSARNKDGRVGMIP 174
Query: 433 ANYVE 437
YVE
Sbjct: 175 VPYVE 179
>Hs4502217 [T] KOG4225 Sorbin and SH3 domain-containing protein
Length = 666
Score = 52.8 bits (125), Expect = 1e-06
Identities = 26/69 (37%), Positives = 42/69 (60%), Gaps = 7/69 (10%)
Query: 374 NSPARNSGAPK-----AVALYTFKGEESGDLPFRKGDVISIIKKSESQDDWWTGRVNGKE 428
++P G P+ A A+Y FK + S +L F+KGD + I++K + +W+ G +G+
Sbjct: 418 SAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKID--QNWYEGEHHGRV 475
Query: 429 GIFPANYVE 437
GIFP +YVE
Sbjct: 476 GIFPISYVE 484
>Hs10947118 [T] KOG4225 Sorbin and SH3 domain-containing protein
Length = 1100
Score = 52.8 bits (125), Expect = 1e-06
Identities = 26/69 (37%), Positives = 42/69 (60%), Gaps = 7/69 (10%)
Query: 374 NSPARNSGAPK-----AVALYTFKGEESGDLPFRKGDVISIIKKSESQDDWWTGRVNGKE 428
++P G P+ A A+Y FK + S +L F+KGD + I++K + +W+ G +G+
Sbjct: 852 SAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKID--QNWYEGEHHGRV 909
Query: 429 GIFPANYVE 437
GIFP +YVE
Sbjct: 910 GIFPISYVE 918
>Hs20070146 [IT] KOG1118 Lysophosphatidic acid acyltransferase endophilin/SH3GL
involved in synaptic vesicle formation
Length = 355
Score = 52.4 bits (124), Expect = 1e-06
Identities = 21/57 (36%), Positives = 38/57 (65%), Gaps = 2/57 (3%)
Query: 383 PKAVALYTFKGEESGDLPFRKGDVISIIKKSESQDDWWTGRVNGKEGIFPANYVELV 439
P LY F+ E G+L F++GD+I++ + + ++W+ G ++G+ G FP NYVE++
Sbjct: 296 PCCRGLYDFEPENQGELGFKEGDIITLTNQID--ENWYEGMIHGESGFFPINYVEVI 350
>Hs5453754 [T] KOG4226 Adaptor protein NCK/Dock contains SH2 and SH3 domains
Length = 377
Score = 52.0 bits (123), Expect = 2e-06
Identities = 23/54 (42%), Positives = 33/54 (60%), Gaps = 1/54 (1%)
Query: 387 ALYTFKGEESGDLPFRKGDVISIIKKSESQDDWWTGR-VNGKEGIFPANYVELV 439
ALY F +L F KGDV+ +I+K E+ +WW R +NG G+ P NYV ++
Sbjct: 197 ALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKINGMVGLVPKNYVTVM 250
>Hs4506931 [IT] KOG1118 Lysophosphatidic acid acyltransferase endophilin/SH3GL
involved in synaptic vesicle formation
Length = 352
Score = 52.0 bits (123), Expect = 2e-06
Identities = 22/57 (38%), Positives = 38/57 (66%), Gaps = 2/57 (3%)
Query: 383 PKAVALYTFKGEESGDLPFRKGDVISIIKKSESQDDWWTGRVNGKEGIFPANYVELV 439
P ALY F+ E G+L F++GD+I++ + + ++W+ G ++G G FP NYVE++
Sbjct: 293 PCCRALYDFEPENEGELGFKEGDIITLTNQID--ENWYEGMLHGHSGFFPINYVEIL 347
>CE29645 [T] KOG4226 Adaptor protein NCK/Dock contains SH2 and SH3 domains
Length = 286
Score = 52.0 bits (123), Expect = 2e-06
Identities = 23/55 (41%), Positives = 33/55 (59%), Gaps = 1/55 (1%)
Query: 386 VALYTFKGEESGDLPFRKGDVISIIKKSESQDDWWTGR-VNGKEGIFPANYVELV 439
VALY+F S +L F+KG+ + I+ E DWW R +G G+ P NY+E+V
Sbjct: 107 VALYSFDASSSEELSFKKGERLEIVDHPEHDPDWWMARNASGTTGLVPRNYIEVV 161
>CE29644 [T] KOG4226 Adaptor protein NCK/Dock contains SH2 and SH3 domains
Length = 398
Score = 52.0 bits (123), Expect = 2e-06
Identities = 23/55 (41%), Positives = 33/55 (59%), Gaps = 1/55 (1%)
Query: 386 VALYTFKGEESGDLPFRKGDVISIIKKSESQDDWWTGR-VNGKEGIFPANYVELV 439
VALY+F S +L F+KG+ + I+ E DWW R +G G+ P NY+E+V
Sbjct: 219 VALYSFDASSSEELSFKKGERLEIVDHPEHDPDWWMARNASGTTGLVPRNYIEVV 273
>7299844 [TZ] KOG2546 Abl interactor ABI-1 contains SH3 domain
Length = 473
Score = 52.0 bits (123), Expect = 2e-06
Identities = 21/54 (38%), Positives = 36/54 (65%), Gaps = 2/54 (3%)
Query: 384 KAVALYTFKGEESGDLPFRKGDVISIIKKSESQDDWWTGRVNGKEGIFPANYVE 437
K VA+Y + ++ +L F++ V+ ++KK++ D WW G ++G G+FP NYVE
Sbjct: 419 KVVAIYDYYADKDDELSFQESSVLYVLKKND--DGWWEGVMDGVTGLFPGNYVE 470
>YPR154w [T] KOG3601 Adaptor protein GRB2 contains SH2 and SH3 domains
Length = 215
Score = 51.6 bits (122), Expect = 2e-06
Identities = 27/67 (40%), Positives = 39/67 (57%), Gaps = 4/67 (5%)
Query: 373 ANSPARNSGAPKAV--ALYTFKGEESGDLPFRKGDVISIIKKSESQDDWWTGRVNGKEGI 430
AN+P S A ALY F ++ GDL + GD + +++K + W+ G NG+ GI
Sbjct: 45 ANAPRNASPASLEYVEALYQFDPQQDGDLGLKPGDKVQLLEKLSPE--WYKGSCNGRTGI 102
Query: 431 FPANYVE 437
FPANYV+
Sbjct: 103 FPANYVK 109
>YHL002w [T] KOG2199 Signal transducing adaptor protein STAM/STAM2
Length = 452
Score = 51.6 bits (122), Expect = 2e-06
Identities = 24/50 (48%), Positives = 31/50 (62%), Gaps = 2/50 (4%)
Query: 387 ALYTFKGEESGDLPFRKGDVISIIKKSESQDDWWTGRVNGKEGIFPANYV 436
ALY E +L FRKGDVI++++ + DWW G + G GIFP NYV
Sbjct: 224 ALYDLTTNEPDELSFRKGDVITVLE--QVYRDWWKGALRGNMGIFPLNYV 271
>Hs4506929 [IT] KOG1118 Lysophosphatidic acid acyltransferase endophilin/SH3GL
involved in synaptic vesicle formation
Length = 368
Score = 51.6 bits (122), Expect = 2e-06
Identities = 22/57 (38%), Positives = 38/57 (66%), Gaps = 2/57 (3%)
Query: 383 PKAVALYTFKGEESGDLPFRKGDVISIIKKSESQDDWWTGRVNGKEGIFPANYVELV 439
P ALY F+ E G+L F +GDVI++ ++ ++W+ G ++G+ G FP +YVE++
Sbjct: 309 PSCKALYDFEPENDGELGFHEGDVITL--TNQIDENWYEGMLDGQSGFFPLSYVEVL 363
>Hs4504111 [T] KOG3601 Adaptor protein GRB2 contains SH2 and SH3 domains
Length = 217
Score = 51.6 bits (122), Expect = 2e-06
Identities = 19/55 (34%), Positives = 35/55 (63%), Gaps = 1/55 (1%)
Query: 384 KAVALYTFKGEESGDLPFRKGDVISIIKKSESQDDWWTGRVNGKEGIFPANYVEL 438
+A+A Y FK +L F++GD++ ++ + E +W+ +NGK+G P NY+E+
Sbjct: 2 EAIAKYDFKATADDELSFKRGDILKVLNE-ECDQNWYKAELNGKDGFIPKNYIEM 55
Score = 51.2 bits (121), Expect = 3e-06
Identities = 22/50 (44%), Positives = 33/50 (66%), Gaps = 2/50 (4%)
Query: 387 ALYTFKGEESGDLPFRKGDVISIIKKSESQDDWWTGRVNGKEGIFPANYV 436
AL+ F +E G+L FR+GD I ++ S+ +WW G +G+ G+FP NYV
Sbjct: 163 ALFDFDPQEDGELGFRRGDFIHVMDNSDP--NWWKGACHGQTGMFPRNYV 210
>Hs11386133 [Z] KOG3565 Cdc42-interacting protein CIP4
Length = 946
Score = 51.6 bits (122), Expect = 2e-06
Identities = 25/69 (36%), Positives = 39/69 (56%), Gaps = 5/69 (7%)
Query: 373 ANSPARNS---GAPKAVALYTFKGEESGDLPFRKGDVISIIKKSESQDDWWTGRVNGKEG 429
A PA+ G +AVA + + G + +L FR+GDV+ + +++ S DWW G NG G
Sbjct: 736 AEMPAQEDDLEGVVEAVACFAYTGRTAQELSFRRGDVLRLHERASS--DWWRGEHNGMRG 793
Query: 430 IFPANYVEL 438
+ P Y+ L
Sbjct: 794 LIPHKYITL 802
>Hs7108367 [T] KOG2996 Rho guanine nucleotide exchange factor VAV3
Length = 845
Score = 51.2 bits (121), Expect = 3e-06
Identities = 23/53 (43%), Positives = 32/53 (59%), Gaps = 1/53 (1%)
Query: 385 AVALYTFKGEESGDLPFRKGDVISIIKKSESQDDWWTGRVNGKEGIFPANYVE 437
A A Y F + +L ++GD+I I+ K + Q WW G + G+ G FPANYVE
Sbjct: 787 AKARYDFCARDRSELSLKEGDIIKILNK-KGQQGWWRGEIYGRVGWFPANYVE 838
>Hs4507871 [T] KOG2996 Rho guanine nucleotide exchange factor VAV3
Length = 878
Score = 51.2 bits (121), Expect = 3e-06
Identities = 22/53 (41%), Positives = 29/53 (54%)
Query: 385 AVALYTFKGEESGDLPFRKGDVISIIKKSESQDDWWTGRVNGKEGIFPANYVE 437
AVA Y F + +L R+GDV+ I + WW G NG+ G FP+ YVE
Sbjct: 821 AVARYNFAARDMRELSLREGDVVRIYSRIGGDQGWWKGETNGRIGWFPSTYVE 873
>Hs21361641 [R] KOG0266 WD40 repeat-containing protein
Length = 1196
Score = 50.8 bits (120), Expect = 4e-06
Identities = 24/56 (42%), Positives = 33/56 (58%), Gaps = 3/56 (5%)
Query: 382 APKAVALYTFKGEESGDLPFRKGDVISIIKKSESQDDWWTGRV-NGKEGIFPANYV 436
AP VALY + S +L +GD+I + K +DWW G + G+EG FPAN+V
Sbjct: 1053 APTVVALYDYTANRSDELTIHRGDIIRVFFK--DNEDWWYGSIGKGQEGYFPANHV 1106
>CE05763 [Z] KOG0162 Myosin class I heavy chain
Length = 1100
Score = 50.8 bits (120), Expect = 4e-06
Identities = 22/62 (35%), Positives = 36/62 (57%), Gaps = 2/62 (3%)
Query: 376 PARNSGAPKAVALYTFKGEESGDLPFRKGDVISIIKKSESQDDWWTGRVNGKEGIFPANY 435
PA+ P +A+Y ++ ++ +L F G I ++ K S WW G+VN + G+FP NY
Sbjct: 1040 PAKPKLNPVVIAVYPYEAQDVDELSFEAGAEIELMNKDAS--GWWQGKVNNRVGLFPGNY 1097
Query: 436 VE 437
V+
Sbjct: 1098 VK 1099
>7304330 [T] KOG4792 Crk family adapters
Length = 271
Score = 50.4 bits (119), Expect = 5e-06
Identities = 22/55 (40%), Positives = 35/55 (63%), Gaps = 3/55 (5%)
Query: 384 KAVALYTFKGEESGDLPFRKGDVISIIKKSESQDDWWTGR-VNGKEGIFPANYVE 437
K + + F G + DLPF++G+V++I++K E D WWT R +GK G P Y++
Sbjct: 110 KVIGKFDFVGSDQDDLPFQRGEVLTIVRKDE--DQWWTARNSSGKIGQIPVPYIQ 162
>7298672 [F] KOG2070 Guanine nucleotide exchange factor
Length = 687
Score = 50.4 bits (119), Expect = 5e-06
Identities = 22/50 (44%), Positives = 33/50 (66%), Gaps = 2/50 (4%)
Query: 387 ALYTFKGEESGDLPFRKGDVISIIKKSESQDDWWTGRVNGKEGIFPANYV 436
A Y+F G + +L F+KGDVI++ ++ + WW G +N K G FP+NYV
Sbjct: 9 AEYSFMGSNNDELCFQKGDVITVTQREDG--GWWEGTLNDKTGWFPSNYV 56
>Hs5729856 [T] KOG3601 Adaptor protein GRB2 contains SH2 and SH3 domains
Length = 217
Score = 50.1 bits (118), Expect = 7e-06
Identities = 21/55 (38%), Positives = 34/55 (61%), Gaps = 1/55 (1%)
Query: 384 KAVALYTFKGEESGDLPFRKGDVISIIKKSESQDDWWTGRVNGKEGIFPANYVEL 438
++VALY+F+ ES +L F KGD + I+ + Q +W+ + G EG P NY+ +
Sbjct: 2 ESVALYSFQATESDELAFNKGDTLKILNMEDDQ-NWYKAELRGVEGFIPKNYIRV 55
Score = 49.7 bits (117), Expect = 9e-06
Identities = 22/62 (35%), Positives = 37/62 (59%), Gaps = 2/62 (3%)
Query: 378 RNSGAPKAVALYTFKGEESGDLPFRKGDVISIIKKSESQDDWWTGRVNGKEGIFPANYVE 437
++ GA A A + F ++ L FR+GD+I ++++ + WW GR G+ G FP +YV+
Sbjct: 156 KSPGACFAQAQFDFSAQDPSQLSFRRGDIIEVLERPDPH--WWRGRSCGRVGFFPRSYVQ 213
Query: 438 LV 439
V
Sbjct: 214 PV 215
>Hs13994242 [T] KOG4348 Adaptor protein CMS/SETA
Length = 665
Score = 50.1 bits (118), Expect = 7e-06
Identities = 16/52 (30%), Positives = 34/52 (64%)
Query: 388 LYTFKGEESGDLPFRKGDVISIIKKSESQDDWWTGRVNGKEGIFPANYVELV 439
++ ++ + +L ++GD++++I K WW G +NG+ G+FP N+V+L+
Sbjct: 275 IFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLL 326
>HsM7262391 [T] KOG2996 Rho guanine nucleotide exchange factor VAV3
Length = 847
Score = 49.7 bits (117), Expect = 9e-06
Identities = 24/53 (45%), Positives = 31/53 (58%), Gaps = 1/53 (1%)
Query: 385 AVALYTFKGEESGDLPFRKGDVISIIKKSESQDDWWTGRVNGKEGIFPANYVE 437
A+A Y F + +L KGDV+ I K S + WW G VNG+ G FP+ YVE
Sbjct: 793 AIARYDFCARDMRELSLLKGDVVKIYTKM-SANGWWRGEVNGRVGWFPSTYVE 844
>Hs8400708 [T] KOG4792 Crk family adapters
Length = 204
Score = 49.7 bits (117), Expect = 9e-06
Identities = 26/61 (42%), Positives = 32/61 (51%), Gaps = 3/61 (4%)
Query: 378 RNSGAPKAVALYTFKGEESGDLPFRKGDVISIIKKSESQDDWWTGR-VNGKEGIFPANYV 436
R A AL+ F G + DLPF+KGD++ I K E Q WW GK G+ P YV
Sbjct: 130 RQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQ--WWNAEDSEGKRGMIPVPYV 187
Query: 437 E 437
E
Sbjct: 188 E 188
>Hs8400706 [T] KOG4792 Crk family adapters
Length = 304
Score = 49.7 bits (117), Expect = 9e-06
Identities = 26/61 (42%), Positives = 32/61 (51%), Gaps = 3/61 (4%)
Query: 378 RNSGAPKAVALYTFKGEESGDLPFRKGDVISIIKKSESQDDWWTGR-VNGKEGIFPANYV 436
R A AL+ F G + DLPF+KGD++ I K E Q WW GK G+ P YV
Sbjct: 130 RQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQ--WWNAEDSEGKRGMIPVPYV 187
Query: 437 E 437
E
Sbjct: 188 E 188
>Hs7382493 [C] KOG4773 NADPH oxidase
Length = 348
Score = 49.7 bits (117), Expect = 9e-06
Identities = 28/69 (40%), Positives = 39/69 (55%), Gaps = 6/69 (8%)
Query: 375 SPARNS----GAPKAVALYTFKGEESGDLPFRKGDVISIIKKSESQDDWWTGRVNGKEGI 430
SP NS AP+A AL+ F G +L F+ GDVI ++ S DW G V G GI
Sbjct: 161 SPQGNSVDRMAAPRAEALFDFTGNSKLELNFKAGDVIFLL--SRINKDWLEGTVRGATGI 218
Query: 431 FPANYVELV 439
FP ++V+++
Sbjct: 219 FPLSFVKIL 227
>Hs4505345 [C] KOG4773 NADPH oxidase
Length = 339
Score = 49.7 bits (117), Expect = 9e-06
Identities = 28/69 (40%), Positives = 39/69 (55%), Gaps = 6/69 (8%)
Query: 375 SPARNS----GAPKAVALYTFKGEESGDLPFRKGDVISIIKKSESQDDWWTGRVNGKEGI 430
SP NS AP+A AL+ F G +L F+ GDVI ++ S DW G V G GI
Sbjct: 161 SPQGNSVDRMAAPRAEALFDFTGNSKLELNFKAGDVIFLL--SRINKDWLEGTVRGATGI 218
Query: 431 FPANYVELV 439
FP ++V+++
Sbjct: 219 FPLSFVKIL 227
>Hs22065489 [T] KOG4792 Crk family adapters
Length = 304
Score = 49.7 bits (117), Expect = 9e-06
Identities = 26/61 (42%), Positives = 32/61 (51%), Gaps = 3/61 (4%)
Query: 378 RNSGAPKAVALYTFKGEESGDLPFRKGDVISIIKKSESQDDWWTGR-VNGKEGIFPANYV 436
R A AL+ F G + DLPF+KGD++ I K E Q WW GK G+ P YV
Sbjct: 130 RQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQ--WWNAEDSEGKRGMIPVPYV 187
Query: 437 E 437
E
Sbjct: 188 E 188
>Hs21614496 [T] KOG2996 Rho guanine nucleotide exchange factor VAV3
Length = 847
Score = 49.7 bits (117), Expect = 9e-06
Identities = 24/53 (45%), Positives = 31/53 (58%), Gaps = 1/53 (1%)
Query: 385 AVALYTFKGEESGDLPFRKGDVISIIKKSESQDDWWTGRVNGKEGIFPANYVE 437
A+A Y F + +L KGDV+ I K S + WW G VNG+ G FP+ YVE
Sbjct: 793 AIARYDFCARDMRELSLLKGDVVKIYTKM-SANGWWRGEVNGRVGWFPSTYVE 844
>7303765 [T] KOG4225 Sorbin and SH3 domain-containing protein
Length = 500
Score = 49.7 bits (117), Expect = 9e-06
Identities = 26/59 (44%), Positives = 39/59 (66%), Gaps = 4/59 (6%)
Query: 383 PKAVA--LYTFKGEESGDLPFRKGDVISIIKKSESQDDWWTGRVNGKEGIFPANYVELV 439
PK VA L+ F+G+ S +L FRKGD I I ++ ++ +W+ G N G+ PA+YVE+V
Sbjct: 244 PKTVARALFNFQGQTSKELSFRKGDTIYIRRQIDA--NWYEGEHNAMIGLLPASYVEIV 300
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.316 0.135 0.396
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,032,869
Number of Sequences: 60738
Number of extensions: 700144
Number of successful extensions: 1714
Number of sequences better than 1.0e-05: 65
Number of HSP's better than 0.0 without gapping: 12
Number of HSP's successfully gapped in prelim test: 53
Number of HSP's that attempted gapping in prelim test: 1565
Number of HSP's gapped (non-prelim): 125
length of query: 439
length of database: 30,389,216
effective HSP length: 109
effective length of query: 330
effective length of database: 23,768,774
effective search space: 7843695420
effective search space used: 7843695420
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)