ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactI2406 good TI KOG4136 Lipid transport and metabolism Predicted mitochondrial cholesterol transporter
r_klactI2406 good TI KOG4136 Signal transduction mechanisms Predicted mitochondrial cholesterol transporter
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactI2406 810967 811644 226
(226 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YHR181w [TI] KOG4136 Predicted mitochondrial cholesterol transpo... 280 1e-75
SPCC1795.10c [TI] KOG4136 Predicted mitochondrial cholesterol tr... 135 6e-32
7291561 [TI] KOG4136 Predicted mitochondrial cholesterol transpo... 107 2e-23
Hs21389355 [TI] KOG4136 Predicted mitochondrial cholesterol tran... 93 3e-19
>YHR181w [TI] KOG4136 Predicted mitochondrial cholesterol transporter
Length = 228
Score = 280 bits (716), Expect = 1e-75
Identities = 138/217 (63%), Positives = 170/217 (77%), Gaps = 4/217 (1%)
Query: 1 MIIQLLSYAGTVLGFIFLTLSTASGLYYLSELVEEYTEPTRRLLYRAIYTIIGIYVXXXX 60
M+++L+SYAGTV GF+FLTLS ASGLYY+SELVEE+TEPTRR L RAIY II I +
Sbjct: 1 MLLELISYAGTVSGFLFLTLSIASGLYYISELVEEHTEPTRRFLTRAIYGIILILILLLL 60
Query: 61 XXXXXXXXTAFSIFTYVVYLQNMKHFPYISLTNPTLMLSCVLVLINHYLWFKYFNDVDIP 120
T FSI Y+VY QN+K FP+ISLT+PT +LSCV V++NHY WFKYFND ++P
Sbjct: 61 LDGFPFKLTLFSIACYIVYYQNLKSFPFISLTSPTFLLSCVCVVLNHYFWFKYFNDTEVP 120
Query: 121 PQFRFDPNYVPRRRASFAEVASFFGICVWFIPFALFVSLSAGENVLPTHIER---KKNED 177
PQF+FDPNY+PRRRASFAEVASFFGICVWFIPFALFVSLSAG+ VLPT E+ KKN+D
Sbjct: 121 PQFKFDPNYIPRRRASFAEVASFFGICVWFIPFALFVSLSAGDYVLPTTSEQHMAKKNDD 180
Query: 178 GDGAESSRGVRRRAKGLAKIVIDYIREYFYSIGKLFG 214
+ R+RA GLA++VI+ +R+Y YS+ ++FG
Sbjct: 181 -ITTNNQPKFRKRAVGLARVVINSVRKYIYSLARVFG 216
>SPCC1795.10c [TI] KOG4136 Predicted mitochondrial cholesterol transporter
Length = 227
Score = 135 bits (339), Expect = 6e-32
Identities = 69/173 (39%), Positives = 104/173 (59%), Gaps = 5/173 (2%)
Query: 1 MIIQLLSYAGTVLGFIFLTLSTASGLYYLSELVEEYTEPTRRLLYRAIYTIIGIYVXXXX 60
+++ LSY G VLGFI +T+S AS LYY+SE VEE++ + L R +Y I+ + V
Sbjct: 2 IVLNALSYLGIVLGFIGMTVSIASALYYISEFVEEHSRLAKAFLCRLVYFIMAVMVFLVI 61
Query: 61 XXXXXXXXTAFSIFTYVVYLQNMKHFPYISLTNPTLMLSCVLVLINHYLWFKYFNDVDIP 120
+AFSIF++ +Y N FP+ S +L+C L++ NH LW ++F + P
Sbjct: 62 FDGFPFWLSAFSIFSHYIYKINFDTFPFFSFKRMRFLLACFLIVANHILWVRFFQVHEFP 121
Query: 121 PQFR-FDPNYVPRR----RASFAEVASFFGICVWFIPFALFVSLSAGENVLPT 168
+ R ++V +R RASF++VASF G+CVW +P +FVS +A +N LPT
Sbjct: 122 IKPRGLTYDFVGQRLLTSRASFSQVASFMGVCVWSVPIGIFVSFTAADNTLPT 174
>7291561 [TI] KOG4136 Predicted mitochondrial cholesterol transporter
Length = 198
Score = 107 bits (266), Expect = 2e-23
Identities = 63/203 (31%), Positives = 103/203 (50%), Gaps = 18/203 (8%)
Query: 2 IIQLLSYAGTVLGFIFLTLSTASGLYYLSELVEEYTEPTRRLLYRAIYTIIGIYVXXXXX 61
++ LL + + +FLTLS +GLYYL+EL EEYT R+ + I I +Y+
Sbjct: 3 VLYLLGWVSLAIQIVFLTLSIVAGLYYLAELAEEYTTAARKCILFLISFTIFVYILLLLF 62
Query: 62 XXXXXXXTAFSIFTYVVYLQNMKHFPYISLTNPTLMLSCVLVLINHYLWFKYFNDVDIPP 121
+ +L M FP++ L + L+ S ++++NH+L F++F V +P
Sbjct: 63 EDLPWSLIICGLVAQGFHLGIMSGFPFVRLLSLPLLGSLAMLVVNHFLAFQHFVTVYVP- 121
Query: 122 QFRFDPNYVPRRRASFAEVASFFGICVWFIPFALFVSLSAGENVLPTHIERKKNEDGDGA 181
F +V ++F IC+W +PFALFVSLSA ++VLPT + + D
Sbjct: 122 ---------------FTQVLAYFTICMWIVPFALFVSLSANDSVLPTTVSDQSRRSPD-V 165
Query: 182 ESSRGVRRRAKGLAKIVIDYIRE 204
S+ R + +GL + Y++E
Sbjct: 166 VSNYFSRNKKQGLLSL-FQYLKE 187
>Hs21389355 [TI] KOG4136 Predicted mitochondrial cholesterol transporter
Length = 149
Score = 92.8 bits (229), Expect = 3e-19
Identities = 56/162 (34%), Positives = 89/162 (54%), Gaps = 23/162 (14%)
Query: 43 LLYRAIYTIIGIYVXXXXXXXXXXXXTAFSIFTYVVYLQNMKHFPYISLTNPTLMLSCVL 102
+++ + +IG+YV +FT +VY ++ FP+I LT+P +LSC L
Sbjct: 1 MIWFSTAVLIGLYVFERFPTSMI----GVGLFTNLVYFGLLQTFPFIMLTSPNFILSCGL 56
Query: 103 VLINHYLWFKYFNDVDIPPQFRFDPNYVPRRRASFAEVASFFGICVWFIPFALFVSLSAG 162
V++NHYL F++F + Y P F+EV ++F C+W IPFA FVSLSAG
Sbjct: 57 VVVNHYLAFQFFAE-----------EYYP-----FSEVLAYFTFCLWIIPFAFFVSLSAG 100
Query: 163 ENVLPTHIERKKNEDGDGAESSRGVRRRAKGLAKIVIDYIRE 204
ENVLP+ ++ +D ++G R + G+ +V +I+E
Sbjct: 101 ENVLPSTMQ--PGDDVVSNYFTKGKRGKRLGIL-VVFSFIKE 139
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.328 0.145 0.436
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,557,270
Number of Sequences: 60738
Number of extensions: 489123
Number of successful extensions: 1476
Number of sequences better than 1.0e-05: 4
Number of HSP's better than 0.0 without gapping: 4
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 1467
Number of HSP's gapped (non-prelim): 4
length of query: 226
length of database: 30,389,216
effective HSP length: 103
effective length of query: 123
effective length of database: 24,133,202
effective search space: 2968383846
effective search space used: 2968383846
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)