ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactI2485 good U KOG1060 Intracellular trafficking, secretion, and vesicular transport Vesicle coat complex AP-3, beta subunit
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactI2485 840970 838595 -792
(792 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YGR261c [U] KOG1060 Vesicle coat complex AP-3 beta subunit 565 e-160
Hs4758760 [U] KOG1060 Vesicle coat complex AP-3 beta subunit 246 1e-64
SPAC23H3.06 [U] KOG1060 Vesicle coat complex AP-3 beta subunit 237 6e-62
Hs4501975 [U] KOG1060 Vesicle coat complex AP-3 beta subunit 232 2e-60
7290497 [U] KOG1060 Vesicle coat complex AP-3 beta subunit 222 2e-57
CE18132 [U] KOG1060 Vesicle coat complex AP-3 beta subunit 222 2e-57
CE12722 [U] KOG1060 Vesicle coat complex AP-3 beta subunit 214 5e-55
At3g55480_2 [U] KOG1060 Vesicle coat complex AP-3 beta subunit 197 4e-50
CE24628 [U] KOG1061 Vesicle coat complex AP-1/AP-2/AP-4 beta sub... 142 3e-33
Hs4557469 [U] KOG1061 Vesicle coat complex AP-1/AP-2/AP-4 beta s... 140 8e-33
HsM4501973 [U] KOG1061 Vesicle coat complex AP-1/AP-2/AP-4 beta ... 140 1e-32
Hs22027653 [U] KOG1061 Vesicle coat complex AP-1/AP-2/AP-4 beta ... 140 1e-32
Hs22027651 [U] KOG1061 Vesicle coat complex AP-1/AP-2/AP-4 beta ... 140 1e-32
At4g23460 [U] KOG1061 Vesicle coat complex AP-1/AP-2/AP-4 beta s... 138 4e-32
SPBC947.02 [U] KOG1061 Vesicle coat complex AP-1/AP-2/AP-4 beta ... 137 5e-32
At4g11380 [U] KOG1061 Vesicle coat complex AP-1/AP-2/AP-4 beta s... 136 1e-31
7293642 [U] KOG1061 Vesicle coat complex AP-1/AP-2/AP-4 beta sub... 135 3e-31
YKL135c [U] KOG1061 Vesicle coat complex AP-1/AP-2/AP-4 beta sub... 113 1e-24
SPBC2G2.06c [U] KOG1061 Vesicle coat complex AP-1/AP-2/AP-4 beta... 107 5e-23
At5g11490 [U] KOG1061 Vesicle coat complex AP-1/AP-2/AP-4 beta s... 99 2e-20
Hs5729742 [U] KOG1061 Vesicle coat complex AP-1/AP-2/AP-4 beta s... 91 9e-18
Hs18596139 [U] KOG1061 Vesicle coat complex AP-1/AP-2/AP-4 beta ... 87 1e-16
YDR238c [U] KOG1058 Vesicle coat complex COPI beta subunit 61 8e-09
>YGR261c [U] KOG1060 Vesicle coat complex AP-3 beta subunit
Length = 809
Score = 565 bits (1455), Expect = e-160
Identities = 317/795 (39%), Positives = 479/795 (59%), Gaps = 46/795 (5%)
Query: 1 MVDSIQRITSVLQSARDLTFGAAAVASSRIGESSYTQYSKSIDPEALTRLLSSRNSREVK 60
MVDSI RI S L +A+ +T AAAVA+S++GESSYT YS++I+P+ L LL+SRNSREV+
Sbjct: 1 MVDSIHRIASALDTAKVITREAAAVATSKLGESSYTYYSQNINPQQLVTLLNSRNSREVR 60
Query: 61 DAMKRVMSLMATNDPTVDLKSMFADILKNISSEDVKVKRMVCIYLLRFAESDPNVALLSV 120
DAMKR++S+MA++D ++D++ FAD++KNI++ D KVKR++ +YLLRFAE+DPN+ LLS+
Sbjct: 61 DAMKRIISIMASDDDSIDVQLYFADVVKNITTNDTKVKRLIHLYLLRFAENDPNLTLLSI 120
Query: 121 NTIQKNLQDRDPEAKALALKALSDINVASLYPITLQSVKKCVSDASPLVRATSAMTLFKL 180
N++QK+L D + E + AL ALSD+ ++SL PI L +VKK V+D S +VR A+ + KL
Sbjct: 121 NSLQKSLSDSNSELRCFALSALSDMKMSSLAPIILHTVKKLVTDPSAMVRGEVALAIIKL 180
Query: 181 FQDSKSHDEEDDVRRHDLVPLLQELLADPDPLVISCTLVVLQNCLPDRLDLLHGHFRRYC 240
++ K+ E +L+ +L+EL+AD DP VISC ++ + C D L+LLHGHFRRYC
Sbjct: 181 YRAGKNDYHE------ELLDILKELMADTDPKVISCAVLAYKECYADHLELLHGHFRRYC 234
Query: 241 AVLPSLSHWAQSLLVEMFIRYSKHFIKRPVFVNREDRSETPLPETPELVDSWFLEANXXX 300
++ L W+QS L+E+ I+Y K ++ +P V++ P+ + +
Sbjct: 235 RIIKQLDSWSQSYLIELLIKYCKQYLPKPTVVDKSSEGSPRSCPLPDKYNEIEYPSYEVV 294
Query: 301 XXXXXXXXXTSLKPLLFSSNASVIISVSRALFMLAPLSKFREFGMPHCLVKALQLSSTE- 359
SL L++SSN +VI+S AL+ LA + + LV+ + ++ +
Sbjct: 295 NDPDLDLFLQSLNCLIYSSNPTVILSCCNALYQLASPLQMKNTKFIEALVRTVTMTENQG 354
Query: 360 NRCIIVQMIAYYASIDPEAFASLYRSFLPTADDDPIVGSYKLTIISLLITDKNVKDIIHE 419
N+ +++Q I + + +D F + F D + +K+ I+S LI + NVK+I E
Sbjct: 355 NKEMLLQAIHFLSILDQTLFLPYTKKFYVFPKDPIVASIWKIQILSTLINESNVKEIFKE 414
Query: 420 LKYYITTYRDPA-IVKKALSTLVVCAHNSNAFSAHIMKWLLSFMENDNLTDSEVTSEYVN 478
LKYY+ + P +V A+ +L C S ++ +H+MKWL+ ME+ NL+ S V YVN
Sbjct: 415 LKYYVASAHFPENVVIMAVKSLSRCGQLSTSWESHVMKWLIDHMESHNLSAS-VLDAYVN 473
Query: 479 VIRHLIQINPSKNLSVMLKLSQIITETDNLSAYAKAGIIWLFGEYIHVEPRIVPDVLRKL 538
VIR L+Q NP+K+L ++ KL+ ++T +L+ A+AGI+WLFGE +E +I PDVLR+L
Sbjct: 474 VIRMLVQKNPTKHLRIIFKLADLLTVQTSLADNARAGIVWLFGEIASIEFKICPDVLRRL 533
Query: 539 IPKFADESTEARLQILILAAKLLSFDIDRCESD--------------YDFEQSRIAHLYD 584
I F++E E R QIL+L+AKLLS+DID + YDF SRI+ +Y+
Sbjct: 534 IQNFSNEGPETRCQILVLSAKLLSYDIDNFKQAQVTGSEENNQNPPYYDFSGSRISQMYN 593
Query: 585 AVMYLAKFDDDFDIRDKVRSLSSLFSHERFEILTLLLQAAKPWPALSLFTYGDKASDLAH 644
AV+YLAK+DD+FDIRD+ R +SSLF ++EI++LLLQA KP F A
Sbjct: 594 AVLYLAKYDDEFDIRDRARMISSLFDSGKYEIVSLLLQAPKPTARSDDFIVS------AR 647
Query: 645 LEL-SPEVLNSLKVPQWSTEVPEVDRT------PVETNNFMKNKSSISSNTFFASRTRAN 697
LE +PE+ ++ W+TE+ EV T E ++ K K S SS +F + + +
Sbjct: 648 LETHTPEIKEFFRMLPWNTEITEVGETGNDIREGAELKDYNKYKKSFSSQSFITNNSARS 707
Query: 698 YQQXXXX-------XXXXXXXXXXXXXXXXXXXGKTYKLQSLDEFFADIPE---KPKKTK 747
+ GK Y+LQSLDEFF+DIPE KP+K
Sbjct: 708 FTSSSNAKLTGINDGDSNSISGKGNVNTFTSQNGKKYRLQSLDEFFSDIPERKSKPRKII 767
Query: 748 IVIEEESETESDVAQ 762
V+EE S+ + D ++
Sbjct: 768 KVVEESSDEDEDESE 782
>Hs4758760 [U] KOG1060 Vesicle coat complex AP-3 beta subunit
Length = 1081
Score = 246 bits (627), Expect = 1e-64
Identities = 195/681 (28%), Positives = 331/681 (47%), Gaps = 72/681 (10%)
Query: 26 ASSRIGESSYTQYSKSIDPEALTRLLSSRNSREVKDAMKRVMSLMATNDPTVDLKSMFAD 85
AS I S Y ++ + L +L + +AMKR+++++A DL F
Sbjct: 27 ASGGIFSSDYKRH------DDLKEMLDTNKDSLKLEAMKRIVAMIARGKNASDL---FPA 77
Query: 86 ILKNISSEDVKVKRMVCIYLLRFAESDPNVALLSVNTIQKNLQDRDPEAKALALKALSDI 145
++KN++ ++++VK++V +YL+R+AE ++ALLS++T Q+ L+D + +A AL+ LS I
Sbjct: 78 VVKNVACKNIEVKKLVYVYLVRYAEEQQDLALLSISTFQRGLKDPNQLIRASALRVLSSI 137
Query: 146 NVASLYPITLQSVKKCVSDASPLVRATSAMTLFKLFQDSKSHDEEDDVRRHDLVPLLQEL 205
V + PI + ++K+ SD SP VR T+A + KL+ S D++D L+ ++++L
Sbjct: 138 RVPIIVPIMMLAIKEAASDMSPYVRKTAAHAIPKLY--SLDSDQKD-----QLIEVIEKL 190
Query: 206 LADPDPLVISCTLVVLQNCLPDRLDLLHGHFRRYCAVLPSLSHWAQSLLVEMFIRYSKHF 265
LAD LV ++ + P+R+DL+H ++R+ C +L + W Q +++ M RY++
Sbjct: 191 LADKTTLVAGSVVMAFEEVCPERIDLIHKNYRKLCNLLIDVEEWGQVVIISMLTRYARTQ 250
Query: 266 IKRPVFVNREDRSETPLPETPE--LVDSWFLEANXXXXXXXXXXXXTS------------ 311
P ++E+ L E E S EA S
Sbjct: 251 FLSPT------QNESLLEENAEKAFYGSEEDEAKGAGSEETAAAAAPSRKPYVMDPDHRL 304
Query: 312 ----LKPLLFSSNASVIISVSRALFMLAPLSKFREFGMPHCLVKALQLSSTENRCIIVQM 367
KPLL S +A+V+++V++ F L P K+R L++ S +E + +++Q
Sbjct: 305 LLRNTKPLLQSRSAAVVMAVAQLYFHLGPRRKWRHRQGAGALLR----SHSEVQYVVLQN 360
Query: 368 IAYYASIDPEAFASLYRSFLPTADDDPIVGSYKLTIISLLITDKNVKDIIHELKYYITTY 427
+A + F +SF + D + KL +++ L + N+ ++ E + YI +
Sbjct: 361 VATMSIKRRGMFEPYLKSFYIRSTDPTQIKILKLEVLTNLANETNIPTVLREFQTYIRS- 419
Query: 428 RDPAIVKKALSTLVVCAHNSNAFSAHIMKWLLSFMENDNLTDSEVTSEYVNVIRHLIQIN 487
D V + + CA N + L+ + N D V +E V VI+ L+Q+
Sbjct: 420 MDKDFVAATIQAIGRCATNIGRVRDTCLNGLVQLLSN---RDELVVAESVVVIKKLLQMQ 476
Query: 488 PSKNLSVMLKLSQIITETDNLSA-YAKAGIIWLFGEYIHVEPRIVPDVLRKLIPKFADES 546
P+++ ++ L+++ TDN+ A+A I+WL GEY PRI PDVLRK+ F E
Sbjct: 477 PAQHGEIIKHLAKL---TDNIQVPMARASILWLIGEYCEHVPRIAPDVLRKMAKSFTAEE 533
Query: 547 TEARLQILILAAKLLSFDIDRCESDYDFEQSRIAHLYDAVMYLAKFDDDFDIRDKVRSLS 606
+LQ++ LAAKL Y + L V+ LAK+D ++DIRD+ R
Sbjct: 534 DIVKLQVINLAAKL-----------YLTNSKQTKLLTQYVLSLAKYDQNYDIRDRARFTR 582
Query: 607 SLF-SHERFEILT----LLLQAAKPWPAL-SLFTYGD--KASDLAHLELSPEVLNSLKVP 658
L E+ L+ L A KP P L S F D + L+HL L+ + ++P
Sbjct: 583 QLIVPSEQGGALSRHAKKLFLAPKPAPVLESSFKDRDHFQLGSLSHL-LNAKATGYQELP 641
Query: 659 QWSTEVPEVDRTPVETNNFMK 679
W E P+ VE + K
Sbjct: 642 DWPEEAPDPSVRNVEVPEWTK 662
>SPAC23H3.06 [U] KOG1060 Vesicle coat complex AP-3 beta subunit
Length = 745
Score = 237 bits (604), Expect = 6e-62
Identities = 171/649 (26%), Positives = 320/649 (48%), Gaps = 57/649 (8%)
Query: 19 TFGAAAVASSRIGESSYTQYSKS-IDPEALTRLLSSRNSREVKDAMKRVMSLMATNDPTV 77
T A + +I +SS + ++ + L RLL+S + +A+ +++ M +
Sbjct: 9 TLSGLAENAKQIAKSSSLSFEENELSHSDLLRLLNSNSDAGKLEAINFILAQMMHGE--- 65
Query: 78 DLKSMFADILKNISSEDVKVKRMVCIYLLRFAESDPNVALLSVNTIQKNLQDRDPEAKAL 137
++ F D++K ++SE+ +++R+V IYLL++AE +P++ALLSVNT+QK L D++P ++
Sbjct: 66 NMSLYFPDVVKLVASENPEIRRLVHIYLLQYAEFNPDLALLSVNTVQKTLYDKNPLTRST 125
Query: 138 ALKALSDINVASLYPITLQSVKKCVSDASPLVRATSAMTLFKLFQDSKSHDEEDDVRRHD 197
A++ +S I V ++ I L ++++C++D + VR ++A+ + K + S+ +
Sbjct: 126 AIRVMSSIRVPAINGIVLLAIQQCITDTADRVRQSAALAITKCYSLDPSY-------KSQ 178
Query: 198 LVPLLQELLADPDPLVISCTLVVLQNCLPDRLDLLHGHFRRYCAVLPSLSHWAQSLLVEM 257
L ++ LL+D P+V+ L + P++L+++H ++ R C + P ++ W + + ++
Sbjct: 179 LEEHIKTLLSDNSPIVVPAALFTFEVVCPEKLEIIHPYYHRICTLFPQMNDWDKVVALKT 238
Query: 258 FIRYSKHFIKRPVFVNREDRSETPLPETPELVDSWFLEANXXXXXXXXXXXXTSLKPLLF 317
+RY+ R P P TP S+K F
Sbjct: 239 LVRYA--------------RLTLPEPSTP-------------STHSDLKELLESIKSCFF 271
Query: 318 SSNASVIISVSRALFMLAPLSKFREFGMPHCLVKALQLSSTENRCIIVQMIAYYASI--- 374
S S II+ +RA + LAP ++ H +V+ L E + + Y + I
Sbjct: 272 SLLPSTIIAGARAFYYLAPSNQM------HLIVEPLLQLLLEKPIVRTTTLRYISQIVYK 325
Query: 375 DPEAFASLYRSFLPTADDDPIVGSYKLTIISLLITDKNVKDIIHELKYYITTYRDPAIVK 434
PE F + +SF A D K+ I+S L+ +N I+ EL YYI ++ +P++
Sbjct: 326 TPELFKNHIKSFFLIASDSDDTCLLKINILSRLLDAQNSSQILPELLYYINSHPNPSVAS 385
Query: 435 KALSTLVVCAHNSNAFSAHIMKWLLSFMENDNLTDSEVTSEYVNVIRHLIQINPSKNLSV 494
A+ L A + + + + LL +++ N S + +E + +R LI +P + +
Sbjct: 386 TAVKALGDFASANISMAPSCLNTLLLLLKSHN---SLIVTEAASSLRLLIHNDPKE---I 439
Query: 495 MLKLSQIITETDNLSAYAKAGIIWLFGEYIHVEPRIVPDVLRKLIPKFADESTEARLQIL 554
L+ ET + AK+ +WL E+I + PR+VPDVLR + FADE+ E + QIL
Sbjct: 440 YLQYLAATYETLEVPR-AKSVTLWLISEHILIIPRLVPDVLRIAVKTFADETLEVKYQIL 498
Query: 555 ILAAKL--LSFDIDRCESDYDFEQSRIAHLYDAVMYLAKFDDDFDIRDKVRSLSSLFSHE 612
L+ +L LS ++ ++D + ++ L++ V+ L FD +D+RD+ R L S
Sbjct: 499 ELSVRLYVLSHSEEK-QNDLESRDDVVSLLFNYVLSLIHFDMSYDLRDRARFYKELASTP 557
Query: 613 RFEILTLLLQAAKPWPALSLFTYGDKASDLAHLELSPEVLNSLKVPQWS 661
E ++ +K + D A L L+ +V+ +P W+
Sbjct: 558 SSEFTRRIVLESKGNSQKEIIASRDYCIGTASLCLNEDVMGYEPIPNWA 606
>Hs4501975 [U] KOG1060 Vesicle coat complex AP-3 beta subunit
Length = 1093
Score = 232 bits (591), Expect = 2e-60
Identities = 175/646 (27%), Positives = 319/646 (49%), Gaps = 43/646 (6%)
Query: 45 EALTRLLSSRNSREVKDAMKRVMSLMATNDPTVDLKSMFADILKNISSEDVKVKRMVCIY 104
E L ++L S DAMKR++ ++A +L F ++KN++S+++++K++V +Y
Sbjct: 45 EDLKQMLESNKDSAKLDAMKRIVGMIAKGKNASEL---FPAVVKNVASKNIEIKKLVYVY 101
Query: 105 LLRFAESDPNVALLSVNTIQKNLQDRDPEAKALALKALSDINVASLYPITLQSVKKCVSD 164
L+R+AE ++ALLS++T Q+ L+D + +A AL+ LS I V + PI + ++K+ +D
Sbjct: 102 LVRYAEEQQDLALLSISTFQRALKDPNQLIRASALRVLSSIRVPIIVPIMMLAIKEASAD 161
Query: 165 ASPLVRATSAMTLFKLFQDSKSHDEEDDVRRHDLVPLLQELLADPDPLVISCTLVVLQNC 224
SP VR +A + KL+ D ++ L+ ++++LL D LV ++ +
Sbjct: 162 LSPYVRKNAAHAIQKLY-------SLDPEQKEMLIEVIEKLLKDKSTLVAGSVVMAFEEV 214
Query: 225 LPDRLDLLHGHFRRYCAVLPSLSHWAQSLLVEMFIRYSKHFIKRP--VFVNREDRSETPL 282
PDR+DL+H ++R+ C +L + W Q +++ M RY++ P ED +
Sbjct: 215 CPDRIDLIHKNYRKLCNLLVDVEEWGQVVIIHMLTRYARTQFVSPWKEGDELEDNGKNFY 274
Query: 283 PETPELVDSWFLEANXXXXXXXXXXXXTSLKPLLFSSNASVIISVSRALFMLAPLSKFRE 342
+ + + + KPLL S NA+V+++V++ + ++P S E
Sbjct: 275 ESDDDQKEKTDKKKKPYTMDPDHRLLIRNTKPLLQSRNAAVVMAVAQLYWHISPKS---E 331
Query: 343 FGMPHCLVKALQLSSTENRCIIVQMIAYYASIDPEAFASLYRSFLPTADDDPIVGSYKLT 402
G+ + L S+ E + I++Q IA + F +SF + D ++ + KL
Sbjct: 332 AGIISKSLVRLLRSNREVQYIVLQNIATMSIQRKGMFEPYLKSFYVRSTDPTMIKTLKLE 391
Query: 403 IISLLITDKNVKDIIHELKYYITTYRDPAIVKKALSTLVVCAHNSNAFSAHIMKWLLSFM 462
I++ L + N+ ++ E + Y+ + +D + T+ CA N + + L+ +
Sbjct: 392 ILTNLANEANISTLLREFQTYVKS-QDKQFAAATIQTIGRCATNILEVTDTCLNGLVCLL 450
Query: 463 ENDNLTDSEVTSEYVNVIRHLIQINPSKNLSVMLKLSQIITETDNLSA-YAKAGIIWLFG 521
N D V +E V VI+ L+Q+ P+++ ++ +++++ D+++ A+A I+WL G
Sbjct: 451 SN---RDEIVVAESVVVIKKLLQMQPAQHGEIIKHMAKLL---DSITVPVARASILWLIG 504
Query: 522 EYIHVEPRIVPDVLRKLIPKFADESTEARLQILILAAKLLSFDIDRCESDYDFEQSRIAH 581
E P+I PDVLRK+ F E +LQIL L AKL Y +
Sbjct: 505 ENCERVPKIAPDVLRKMAKSFTSEDDLVKLQILNLGAKL-----------YLTNSKQTKL 553
Query: 582 LYDAVMYLAKFDDDFDIRDKVRSLSSLF-SHERFEILT----LLLQAAKPWPAL-SLFTY 635
L ++ L K+D ++DIRD+ R + L +E+ L+ + A KP P L S F
Sbjct: 554 LTQYILNLGKYDQNYDIRDRTRFIRQLIVPNEKSGALSKYAKKIFLAQKPAPLLESPFKD 613
Query: 636 GD--KASDLAHLELSPEVLNSLKVPQWSTEVPEVDRTPVETNNFMK 679
D + L+H L+ + L++ W P+ VE K
Sbjct: 614 RDHFQLGTLSH-TLNIKATGYLELSNWPEVAPDPSVRNVEVIELAK 658
>7290497 [U] KOG1060 Vesicle coat complex AP-3 beta subunit
Length = 1160
Score = 222 bits (566), Expect = 2e-57
Identities = 171/636 (26%), Positives = 308/636 (47%), Gaps = 79/636 (12%)
Query: 13 QSARDLTFGAAAVASSRIGESSYTQYSKSIDPEALTRLLSSRNSREVKDAMKRVMSLMAT 72
Q D+ FGA + + +S ++ + L ++L S +AMKR++ ++A
Sbjct: 20 QMGLDVEFGADPASGAAFFQSDGRKH------DDLKQMLDSNKDGLKLEAMKRIIGMIAR 73
Query: 73 NDPTVDLKSMFADILKNISSEDVKVKRMVCIYLLRFAESDPNVALLSVNTIQKNLQDRDP 132
DL F ++KN+ S++++VK++V +YL+R+AE ++ALLS++T Q+ L+D +
Sbjct: 74 GRDASDL---FPAVVKNVVSKNIEVKKLVYVYLVRYAEEQQDLALLSISTFQRALKDPNQ 130
Query: 133 EAKALALKALSDINVASLYPITLQSVKKCVSDASPLVRATSAMTLFKLFQDSKSHDEEDD 192
+A AL+ LS I V+ + PI + +++ +D SP VR T+A + KL+ S D++D
Sbjct: 131 LIRASALRVLSSIRVSMIVPIVMLAIRDSAADLSPYVRKTAAHAIPKLY--SLDADQKD- 187
Query: 193 VRRHDLVPLLQELLADPDPLVISCTLVVLQNCLPDRLDLLHGHFRRYCAVLPSLSHWAQS 252
+LV ++++LL+D LV+ ++ P+R+DL+H ++R+ C L + W Q
Sbjct: 188 ----ELVMVIEKLLSDRTTLVVGSAVMAFDEVCPERVDLIHKNYRKLCNFLLDVDEWGQV 243
Query: 253 LLVEMFIRYSKHFIKRPVFVNREDRSETPLPETPELVDSWFLE----------------- 295
+++ M RY++ P + ED L ETP V F +
Sbjct: 244 IIINMLTRYARTQFVDP-NADDEDLVNDGLGETP--VSERFYDESSHSSSHSDDGSSDDE 300
Query: 296 -----------------------ANXXXXXXXXXXXXTSLKPLLFSSNASVIISVSRALF 332
+N KPLL S NASV+++V++
Sbjct: 301 KNKSSTNNKNNGGGNGSRTPSSPSNSYHIDVDHRLLLRQTKPLLQSRNASVVMAVAQLYH 360
Query: 333 MLAPLSKFREFGMPHCLVKALQLSSTENRCIIVQMIAYYASIDPEAFASLYRSFLPTADD 392
+AP ++ + + L++ L+ S E + +++ IA ++ F +SF D
Sbjct: 361 HVAPKNEVQL--IAKALIRLLR-SHKEVQSVVLNCIASMSTKRKAIFEPHLKSFFVRTSD 417
Query: 393 DPIVGSYKLTIISLLITDKNVKDIIHELKYYITTYRDPAIVKKALSTLVVCAHNSNAFSA 452
+ KL I++ L + ++ I+ E + YI++ D + V + + CA + +
Sbjct: 418 PTHIKLLKLDILTNLASAGSISLILREFQTYISS-SDRSFVAATIQAIGRCASSIKEVTE 476
Query: 453 HIMKWLLSFMENDNLTDSEVTSEYVNVIRHLIQINPSKNLSVMLKLSQIITETDNLSAYA 512
+ L+ + N D V +E V VI+ L+Q +++ ++ +++++I + N+ A A
Sbjct: 477 TCLSGLVHLLSNH---DEHVVAESVVVIKRLLQTKAAEHFEIITQMAKLI-DYINVPA-A 531
Query: 513 KAGIIWLFGEYIHVEPRIVPDVLRKLIPKFADESTEARLQILILAAKLLSFDIDRCESDY 572
+A IIWL GEY P I PDVLRK+ F DE +LQ+L L KL Y
Sbjct: 532 RAAIIWLIGEYNEKVPLIAPDVLRKMAKSFVDEQDVVKLQVLNLGVKL-----------Y 580
Query: 573 DFEQSRIAHLYDAVMYLAKFDDDFDIRDKVRSLSSL 608
+ + L V LA++D ++D+RD+ R L +
Sbjct: 581 LTNPEQTSLLCQYVFTLARYDPNYDVRDRARFLRQI 616
>CE18132 [U] KOG1060 Vesicle coat complex AP-3 beta subunit
Length = 896
Score = 222 bits (565), Expect = 2e-57
Identities = 174/630 (27%), Positives = 300/630 (47%), Gaps = 66/630 (10%)
Query: 47 LTRLLSSRNSREVKDAMKRVMSLMATNDPTVDLKSMFADILKNISSEDVKVKRMVCIYLL 106
L +L S DAMKR+++L+A D+ +FA ++KN+++++V++K++V +YL+
Sbjct: 19 LKAMLDSNKDNLKVDAMKRIINLIAKGK---DVSELFAAVVKNVAAKNVELKKLVFVYLV 75
Query: 107 RFAESDPNVALLSVNTIQKNLQDRDPEAKALALKALSDINVASLYPITLQSVKKCVSDAS 166
R+AE ++ALLS++T Q+ L+D + + AL+ L+ I V + PI L ++K V D S
Sbjct: 76 RYAEEQQDLALLSISTFQRALKDPNQLIRGSALRVLTSIRVPMVAPIMLLAIKDAVRDMS 135
Query: 167 PLVRATSAMTLFKLFQDSKSHDEEDDVRRHDLVPLLQELLADPDPLVISCTLVVLQNCLP 226
P VR +A + KL+ + + LV + LLAD LV+ + P
Sbjct: 136 PYVRKVAAHAIPKLYSLEPELEPQ-------LVDCIDFLLADRRSLVLGSAVYAFDEICP 188
Query: 227 DRLDLLHGHFRRYCAVLPSLSHWAQSLLVEMFIRYSKHFIKRPVFVNREDRSETPLPETP 286
RLDLLH HFR C L + W Q +++ M RY++H + P DR P+T
Sbjct: 189 HRLDLLHKHFRALCRGLADVDEWGQIVMINMLTRYARHELADP------DRGP---PDTD 239
Query: 287 ELVDSWFLEANXXXXXXXXXXXXTSLKPLLFSSNASVIISVSRALFMLAPLSKFREFGMP 346
++ S +PLL S N SV+++V + + +AP ++ + +
Sbjct: 240 VVL------------------LLNSARPLLQSRNCSVVMAVVQLFYHVAPKAQLSQ--IA 279
Query: 347 HCLVKALQLSSTENRCIIVQMIAYYASIDPEAFASLYRSFLPTADDDPIVGSYKLTIISL 406
LV+ L+ E + +++ IA +P F +SF + D +V KL +++
Sbjct: 280 RALVRLLR-GPRETQYVVLTNIATICERNPTMFDPFLKSFFVRSCDSSLVKKLKLHVLTS 338
Query: 407 LITDKNVKDIIHELKYYITTYRDPAIVKKALSTLVVCAHNSNAFSAHIMKWLLSFMENDN 466
L+++ NV I+ EL+ Y+ + A+ + CA A S M L+ + +
Sbjct: 339 LVSEANVHIILRELQTYV---HMSDLASPAVEAIGRCAVRVGAVSDQCMTGLVQLISS-- 393
Query: 467 LTDSEVTSEYVNVIRHLIQINPSKNLSVMLKLSQIITETDN-LSAYAKAGIIWLFGEYIH 525
+D +V V VI+ L+ + NL LS+++ N ++A A+A +IWL ++
Sbjct: 394 -SDEKVVCSAVVVIKRLLHASAPLNL-----LSRLMRLMPNMIAAQARACVIWLVATHVE 447
Query: 526 VEPRIVPDVLRKLIPKFADESTEARLQILILAAKLLSFDIDRCESDYDFEQSRIAHLYDA 585
+ PD LR + KF+ E+ +L+ L LA KL D E +
Sbjct: 448 QVLHMAPDFLRLIAKKFSTENELVKLEALKLAVKLWLVKRDDSEK-----------IVQY 496
Query: 586 VMYLAKFDDDFDIRDKVRSLSSLFSHERF--EILTLLLQAAKPWPALSLFTYGDKASDLA 643
V LA+FD +D+RD+ R L +L + + + + + KP P L + ++ + S +
Sbjct: 497 VFQLARFDLSYDVRDRCRFLRNLMFNTEILSQHMEEIFMSKKPAPEL-ISSFKEPTSSDS 555
Query: 644 HLELSPEVLNSLKVPQWSTEVPEVDRTPVE 673
L N LK+ E + D E
Sbjct: 556 LLRKEAHAPNELKLDDSDEEEDDDDEDEEE 585
>CE12722 [U] KOG1060 Vesicle coat complex AP-3 beta subunit
Length = 906
Score = 214 bits (544), Expect = 5e-55
Identities = 174/640 (27%), Positives = 300/640 (46%), Gaps = 76/640 (11%)
Query: 47 LTRLLSSRNSREVKDAMKRVMSLMATNDPTVDLKSMFADILKNISSEDVKVKRMVCIYLL 106
L +L S DAMKR+++L+A D+ +FA ++KN+++++V++K++V +YL+
Sbjct: 19 LKAMLDSNKDNLKVDAMKRIINLIAKGK---DVSELFAAVVKNVAAKNVELKKLVFVYLV 75
Query: 107 RFAESDPNVALLSVNTIQKNLQDRDPEAKALALKALSDINVASLYPITLQSVKKCVSDAS 166
R+AE ++ALLS++T Q+ L+D + + AL+ L+ I V + PI L ++K V D S
Sbjct: 76 RYAEEQQDLALLSISTFQRALKDPNQLIRGSALRVLTSIRVPMVAPIMLLAIKDAVRDMS 135
Query: 167 PLVRATSAMTLFKLFQDSKSHDEEDDVRRHDLVPLLQELLADPDPLVISCTLVVLQNCLP 226
P VR +A + KL+ + + LV + LLAD LV+ + P
Sbjct: 136 PYVRKVAAHAIPKLYSLEPELEPQ-------LVDCIDFLLADRRSLVLGSAVYAFDEICP 188
Query: 227 DRLDLLHGHFRRYCAVLPSLSHWAQSLLVEMFIRYSKHFIKRPVFVNREDRSETPLPETP 286
RLDLLH HFR C L + W Q +++ M RY++H + P DR P+T
Sbjct: 189 HRLDLLHKHFRALCRGLADVDEWGQIVMINMLTRYARHELADP------DRGP---PDTD 239
Query: 287 ELVDSWFLEANXXXXXXXXXXXXTSLKPLLFSSNASVIISVSRALFMLAPLSKFREFGMP 346
++ S +PLL S N SV+++V + + +AP ++ + +
Sbjct: 240 VVL------------------LLNSARPLLQSRNCSVVMAVVQLFYHVAPKAQLSQ--IA 279
Query: 347 HCLVKALQLSSTENRCIIVQMIAYYASIDP----------EAFASLYRSFLPTADDDPIV 396
LV+ L+ E + +++ IA +P F +SF + D +V
Sbjct: 280 RALVRLLR-GPRETQYVVLTNIATICERNPVEEGTYAISKTMFDPFLKSFFVRSCDSSLV 338
Query: 397 GSYKLTIISLLITDKNVKDIIHELKYYITTYRDPAIVKKALSTLVVCAHNSNAFSAHIMK 456
KL +++ L+++ NV I+ EL+ Y+ + A+ + CA A S M
Sbjct: 339 KKLKLHVLTSLVSEANVHIILRELQTYV---HMSDLASPAVEAIGRCAVRVGAVSDQCMT 395
Query: 457 WLLSFMENDNLTDSEVTSEYVNVIRHLIQINPSKNLSVMLKLSQIITETDN-LSAYAKAG 515
L+ + + +D +V V VI+ L+ + NL LS+++ N ++A A+A
Sbjct: 396 GLVQLISS---SDEKVVCSAVVVIKRLLHASAPLNL-----LSRLMRLMPNMIAAQARAC 447
Query: 516 IIWLFGEYIHVEPRIVPDVLRKLIPKFADESTEARLQILILAAKLLSFDIDRCESDYDFE 575
+IWL ++ + PD LR + KF+ E+ +L+ L LA KL D E
Sbjct: 448 VIWLVATHVEQVLHMAPDFLRLIAKKFSTENELVKLEALKLAVKLWLVKRDDSEK----- 502
Query: 576 QSRIAHLYDAVMYLAKFDDDFDIRDKVRSLSSLFSHERF--EILTLLLQAAKPWPALSLF 633
+ V LA+FD +D+RD+ R L +L + + + + + KP P L +
Sbjct: 503 ------IVQYVFQLARFDLSYDVRDRCRFLRNLMFNTEILSQHMEEIFMSKKPAPEL-IS 555
Query: 634 TYGDKASDLAHLELSPEVLNSLKVPQWSTEVPEVDRTPVE 673
++ + S + L N LK+ E + D E
Sbjct: 556 SFKEPTSSDSLLRKEAHAPNELKLDDSDEEEDDDDEDEEE 595
>At3g55480_2 [U] KOG1060 Vesicle coat complex AP-3 beta subunit
Length = 1113
Score = 197 bits (502), Expect = 4e-50
Identities = 159/632 (25%), Positives = 297/632 (46%), Gaps = 87/632 (13%)
Query: 43 DPEA--LTRLLSSRNSREVKDAMKRVMSLMATNDPTVDLKSMFADILKNISSEDVKVKRM 100
DPE + LL S+ E +A+KR+++L+A D+ + F ++KN++S+ +VK++
Sbjct: 8 DPEDVNIAPLLDSKFESEKCEALKRLLALIAQG---FDVSNFFPQVVKNVASQSSEVKKL 64
Query: 101 VCIYLLRFAESDPNVALLSVNTIQKNLQDRDPEAKALALKALSDINVASLYPITLQSVKK 160
V +YLL++AE PN ALLS+N QK+L D +P +A AL+ ++ I + + P+ L +V K
Sbjct: 65 VYLYLLQYAEKRPNEALLSINYFQKDLGDPNPLVRAWALRTMAGIRLHVIAPLALAAVSK 124
Query: 161 CVSDASPLVRATSAMTLFKLFQDSKSHDEEDDVRRHDLVPLLQELLADPDPLVISCTLVV 220
C D + VR +A L KL HD + + L+ LL D P V+
Sbjct: 125 CARDPAVYVRRCAANALPKL------HDLRLEEHASAIEELVGILLNDHSPGVVGAAAAA 178
Query: 221 LQNCLPDRLDLLHGHFRRYCAVLPSLSHWAQSLLVEMFIRY------------------- 261
+ P+ L+ ++++ C +LP + W Q LL+ +RY
Sbjct: 179 FTSICPNNFKLIGKNYKKLCQILPDVEEWGQILLIGTLLRYVVARHGLVRESLMLSIHGT 238
Query: 262 ------SKHFIKRPVFVNRED--RSETPLPETPELVDSWFLE----------ANXXXXXX 303
K + R + +++ED +S++ LV +++
Sbjct: 239 NSNGFCEKDGLGRDLTLDKEDGGKSDSFDVNLVSLVSKCYIQGPDEYLSRSSCTDTVSSA 298
Query: 304 XXXXXXTSL-------------KPLLFSSNASVIISVSRALFMLAPLSKFREFGMPHCLV 350
TS+ PLL+S+N++V+++ + +++APL ++ P +
Sbjct: 299 FDTKETTSIAHNEDVKILLQCTSPLLWSNNSAVVLAAAGVQWIMAPLEDVKKIVKP---L 355
Query: 351 KALQLSSTENRCIIVQMIAYYASIDPEAFASLYRSFLPTADDDPIVGSYKLTIISLLITD 410
L SS+ ++ +++ I +A P FA + +F + D V +YKL ++SL+ T
Sbjct: 356 LFLLRSSSASKYVVLCNILVFAKAVPSLFAPHFENFFICSSDAYQVKAYKLEMLSLIATT 415
Query: 411 KNVKDIIHELKYYITTYRDPAIVKKALSTLVVCAHNSNAFSAHIMKWLLSFMENDNLT-- 468
++ I+ E + YI D ++ + +CA + LL+ + ++
Sbjct: 416 SSIASILREFEDYIKD-PDRRFAADTVAAIGLCAKRLMTIPTTCLDGLLALVRQESFAGD 474
Query: 469 ------DSEVTSEYVNVIRHLIQINPSKNLSVMLKLSQIITETDNLS-AYAKAGIIWLFG 521
++ V + V I+ +I+ +P ++ V++ Q+ D++ A A+A IIW+ G
Sbjct: 475 FESADGEAGVLVQAVMSIQTMIERDPLRHEKVLI---QLFRSLDSIKVAAARATIIWMVG 531
Query: 522 EYI---HVEPRIVPDVLRKLIPKFADESTEARLQILILAAKLLSFDIDRCESDYDFEQSR 578
Y H+ PR++ + + L F E++E +LQIL AK+L I D+ +
Sbjct: 532 VYCSLGHIIPRMLTTITKYLAWSFKSEASETKLQILNTIAKVL---ISAEAGDFHMLKRI 588
Query: 579 IAHLYDAVMYLAKFDDDFDIRDKVRSLSSLFS 610
+ ++++ L ++D +DIRD+ R L L S
Sbjct: 589 VVYVFE----LGEYDLSYDIRDRTRFLKKLLS 616
>CE24628 [U] KOG1061 Vesicle coat complex AP-1/AP-2/AP-4 beta subunit
Length = 827
Score = 142 bits (357), Expect = 3e-33
Identities = 127/540 (23%), Positives = 243/540 (44%), Gaps = 65/540 (12%)
Query: 32 ESSYTQYSKSIDPEALTRLLSSRNSREVKDAMKRVMSLMATNDPTVDLKSMFADILKNIS 91
+S Y +K + L L+S + K+A+K+V++ M D+ ++F D++ +
Sbjct: 3 DSKYFTTTKKGEIFELKNELNSDKKEKKKEAVKKVIASMTVGK---DVSALFPDVVNCMQ 59
Query: 92 SEDVKVKRMVCIYLLRFAESDPNVALLSVNTIQKNLQDRDPEAKALALKALSDINVASLY 151
+++V++K++V +YL+ +A+S P++A+++VNT K+ +D +P +ALA++ + I V +
Sbjct: 60 TDNVELKKLVYLYLMNYAKSQPDLAIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVEKIT 119
Query: 152 PITLQSVKKCVSDASPLVRATSAMTLFKLFQDSKSHDEEDD-VRRHDLVPLLQELLADPD 210
+++C+ D P VR T+A+ + KL HD V+ V LL +LL+D +
Sbjct: 120 EYLCDPLRRCMKDEDPYVRKTAAVCVAKL------HDMNPALVKEQGFVELLNDLLSDAN 173
Query: 211 PLVISCTLVVL--QNCLPDRLDLLHGHFRRYCAVLPSLSHWAQSLLVEMFIRYSKHFIKR 268
P+V++ + L N +++ + L + W Q +++ Y+
Sbjct: 174 PMVVANAVAALTEMNEQQTVIEVNSQMVNKLLTALNECTEWGQVFILDALAGYTP----- 228
Query: 269 PVFVNREDRSETPLPETPELVDSWFLEANXXXXXXXXXXXXTSLKPLLFSSNASVIISVS 328
R++R ET + + + P L +NA+V++S
Sbjct: 229 -----RDER------ETQNICE--------------------RISPRLAHANAAVVLSTV 257
Query: 329 RALFMLAPLSKFREFGMPHCLVK------ALQLSSTENRCIIVQMIAYYASIDPEAFASL 382
+ L L + + K L + E + + ++ I P+
Sbjct: 258 KVLMKLIDMMPADSDFITQLTKKLAPPMVTLLSAEPEIQYVALRNINLIVQKRPDILKQE 317
Query: 383 YRSFLPTADDDPIVGSYKLTIISLLITDKNVKDIIHELKYYITTYRDPAIVKKALSTLVV 442
+ F +D V KL I+ L N+ ++ ELK Y T D V+K++ +
Sbjct: 318 MKVFFVKYNDPIYVKMEKLDIMIRLAQQNNIAQVLSELKEYATEV-DVDFVRKSVRAIGR 376
Query: 443 CAHNSNAFSAHIMKWLLSFMENDNLTDSEVTSEYVNVIRHLIQINPSKNLSVMLKLSQII 502
CA A S ++ LL ++ + V E V VI+ + + P++ S++ L + +
Sbjct: 377 CAIKVEASSERCVQTLLELIQT---KVNYVVQEAVVVIKDIFRKYPNRYESIISALCENL 433
Query: 503 TETDNLSAYAKAGIIWLFGEYIHVEPRI--VPDVLRKLIPKFADESTEARLQILILAAKL 560
D A+A +IW+ GEY RI ++L + F DE+T+ +LQ+L KL
Sbjct: 434 DTLD--EPEARASMIWIIGEYAE---RIDNADELLESFVEGFHDENTQVQLQLLTAVVKL 488
>Hs4557469 [U] KOG1061 Vesicle coat complex AP-1/AP-2/AP-4 beta subunit
Length = 937
Score = 140 bits (353), Expect = 8e-33
Identities = 136/585 (23%), Positives = 258/585 (43%), Gaps = 80/585 (13%)
Query: 32 ESSYTQYSKSIDPEALTRLLSSRNSREVKDAMKRVMSLMATNDPTVDLKSMFADILKNIS 91
+S Y +K + L L++ + K+A+K+V++ M D+ S+F D++ +
Sbjct: 3 DSKYFTTNKKGEIFELKAELNNEKKEKRKEAVKKVIAAMTVGK---DVSSLFPDVVNCMQ 59
Query: 92 SEDVKVKRMVCIYLLRFAESDPNVALLSVNTIQKNLQDRDPEAKALALKALSDINVASLY 151
++++++K++V +YL+ +A+S P++A+++VN+ K+ +D +P +ALA++ + I V +
Sbjct: 60 TDNLELKKLVYLYLMNYAKSQPDMAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKIT 119
Query: 152 PITLQSVKKCVSDASPLVRATSAMTLFKLFQDSKSHDEEDDVRRHDLVPLLQELLADPDP 211
+ ++KC+ D P VR T+A+ + KL D + ED + L++L+AD +P
Sbjct: 120 EYLCEPLRKCLKDEDPYVRKTAAVCVAKL-HDINAQMVED----QGFLDSLRDLIADSNP 174
Query: 212 LVISCTLVVLQNCLPDR-----LDLLHGHFRRYCAVLPSLSHWAQSLLVEMFIRYSKHFI 266
+V++ + L LDL + + L + W Q +++ Y+
Sbjct: 175 MVVANAVAALSEISESHPNSNLLDLNPQNINKLLTALNECTEWGQIFILDCLSNYNP--- 231
Query: 267 KRPVFVNREDRSETPLPETPELVDSWFLEANXXXXXXXXXXXXTSLKPLLFSSNASVIIS 326
++DR + E + P L +N++V++S
Sbjct: 232 -------KDDREAQSICE--------------------------RVTPRLSHANSAVVLS 258
Query: 327 VSRALFMLAPLSKFREFGMPHCLVK-------ALQLSSTENRCIIVQMIAYYASIDPEAF 379
+ L L ++ + L+K L E + + ++ I PE
Sbjct: 259 AVKVLMKFLELLP-KDSDYYNMLLKKLAPPLVTLLSGEPEVQYVALRNINLIVQKRPEIL 317
Query: 380 ASLYRSFLPTADDDPIVGSYKLTIISLLITDKNVKDIIHELKYYITTYRDPAIVKKALST 439
+ F +D V KL I+ L + N+ ++ ELK Y T D V+KA+
Sbjct: 318 KQEIKVFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKEYATEV-DVDFVRKAVRA 376
Query: 440 LVVCAHNSNAFSAHIMKWLLSFMENDNLTDSEVTSEYVNVIRHLIQINPSKNLSVMLKLS 499
+ CA + + LL ++ + V E + VIR + + P+K S++ L
Sbjct: 377 IGRCAIKVEQSAERCVSTLLDLIQT---KVNYVVQEAIVVIRDIFRKYPNKYESIIATLC 433
Query: 500 QIITETDNLSAYAKAGIIWLFGEYIHVEPRI--VPDVLRKLIPKFADESTEARLQILILA 557
+ + D A+A +IW+ GEY RI ++L + F DEST+ +L +L
Sbjct: 434 ENLDSLDEPD--ARAAMIWIVGEYAE---RIDNADELLESFLEGFHDESTQVQLTLLTAI 488
Query: 558 AKLLSFDIDRCESDYDFEQSRIAHLYDAVMYLAKFD-DDFDIRDK 601
KL + + S L V+ LA D D+ D+RD+
Sbjct: 489 VKL-----------FLKKPSETQELVQQVLSLATQDSDNPDLRDR 522
>HsM4501973 [U] KOG1061 Vesicle coat complex AP-1/AP-2/AP-4 beta subunit
Length = 949
Score = 140 bits (352), Expect = 1e-32
Identities = 138/585 (23%), Positives = 261/585 (44%), Gaps = 80/585 (13%)
Query: 32 ESSYTQYSKSIDPEALTRLLSSRNSREVKDAMKRVMSLMATNDPTVDLKSMFADILKNIS 91
+S Y +K + L L+S + K+A+K+V++ M D+ ++F D++ +
Sbjct: 3 DSKYFTTTKKGEIFELKAELNSDKKEKKKEAVKKVIASMTVGK---DVSALFPDVVNCMQ 59
Query: 92 SEDVKVKRMVCIYLLRFAESDPNVALLSVNTIQKNLQDRDPEAKALALKALSDINVASLY 151
++++++K++V +YL+ +A+S P++A+++VNT K+ +D +P +ALA++ + I V +
Sbjct: 60 TDNLELKKLVYLYLMNYAKSQPDMAIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDKIT 119
Query: 152 PITLQSVKKCVSDASPLVRATSAMTLFKLFQDSKSHDEEDDVRRHDLVPLLQELLADPDP 211
+ ++KC+ D P VR T+A+ + KL D + ED + L++L++D +P
Sbjct: 120 EYLCEPLRKCLKDEDPYVRKTAAVCVAKL-HDINAQLVED----QGFLDTLKDLISDSNP 174
Query: 212 LVISCTLVVLQNCLPDR-----LDLLHGHFRRYCAVLPSLSHWAQSLLVEMFIRYSKHFI 266
+V++ + L LDL + L + W Q +++ Y
Sbjct: 175 MVVANAVAALSEIAESHPSSNLLDLNPQSINKLLTALNECTEWGQIFILDCLANY----- 229
Query: 267 KRPVFVNREDRSETPLPETPELVDSWFLEANXXXXXXXXXXXXTSLKPLLFSSNASVIIS 326
+ ++DR + E + P L +N++V++S
Sbjct: 230 -----MPKDDREAQSICE--------------------------RVTPRLSHANSAVVLS 258
Query: 327 VSRALF-MLAPLSKFREF------GMPHCLVKALQLSSTENRCIIVQMIAYYASIDPEAF 379
+ L + LSK ++ + LV L + E + + ++ I PE
Sbjct: 259 AVKVLMKFMEMLSKDLDYYGTLLKKLAPPLVTLLS-AEPELQYVALRNINLIVQKRPEIL 317
Query: 380 ASLYRSFLPTADDDPIVGSYKLTIISLLITDKNVKDIIHELKYYITTYRDPAIVKKALST 439
+ F +D V KL I+ L + N+ ++ ELK Y T D V+KA+
Sbjct: 318 KHEMKVFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKEYATEV-DVDFVRKAVRA 376
Query: 440 LVVCAHNSNAFSAHIMKWLLSFMENDNLTDSEVTSEYVNVIRHLIQINPSKNLSVMLKLS 499
+ CA + + LL ++ + V E + VI+ + + P+K SV+ L
Sbjct: 377 IGRCAIKVEQSAERCVSTLLDLIQT---KVNYVVQEAIVVIKDIFRKYPNKYESVIATLC 433
Query: 500 QIITETDNLSAYAKAGIIWLFGEYIHVEPRI--VPDVLRKLIPKFADESTEARLQILILA 557
+ + D A+A +IW+ GEY RI ++L + F DEST+ +LQ+L
Sbjct: 434 ENLDSLD--EPEARAAMIWIVGEYAE---RIDNADELLESFLEGFHDESTQVQLQLLTAI 488
Query: 558 AKLLSFDIDRCESDYDFEQSRIAHLYDAVMYLAKFD-DDFDIRDK 601
KL + + + L V+ LA D D+ D+RD+
Sbjct: 489 VKL-----------FLKKPTETQELVQQVLSLATQDSDNPDLRDR 522
>Hs22027653 [U] KOG1061 Vesicle coat complex AP-1/AP-2/AP-4 beta subunit
Length = 942
Score = 140 bits (352), Expect = 1e-32
Identities = 138/585 (23%), Positives = 261/585 (44%), Gaps = 80/585 (13%)
Query: 32 ESSYTQYSKSIDPEALTRLLSSRNSREVKDAMKRVMSLMATNDPTVDLKSMFADILKNIS 91
+S Y +K + L L+S + K+A+K+V++ M D+ ++F D++ +
Sbjct: 3 DSKYFTTTKKGEIFELKAELNSDKKEKKKEAVKKVIASMTVGK---DVSALFPDVVNCMQ 59
Query: 92 SEDVKVKRMVCIYLLRFAESDPNVALLSVNTIQKNLQDRDPEAKALALKALSDINVASLY 151
++++++K++V +YL+ +A+S P++A+++VNT K+ +D +P +ALA++ + I V +
Sbjct: 60 TDNLELKKLVYLYLMNYAKSQPDMAIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDKIT 119
Query: 152 PITLQSVKKCVSDASPLVRATSAMTLFKLFQDSKSHDEEDDVRRHDLVPLLQELLADPDP 211
+ ++KC+ D P VR T+A+ + KL D + ED + L++L++D +P
Sbjct: 120 EYLCEPLRKCLKDEDPYVRKTAAVCVAKL-HDINAQLVED----QGFLDTLKDLISDSNP 174
Query: 212 LVISCTLVVLQNCLPDR-----LDLLHGHFRRYCAVLPSLSHWAQSLLVEMFIRYSKHFI 266
+V++ + L LDL + L + W Q +++ Y
Sbjct: 175 MVVANAVAALSEIAESHPSSNLLDLNPQSINKLLTALNECTEWGQIFILDCLANY----- 229
Query: 267 KRPVFVNREDRSETPLPETPELVDSWFLEANXXXXXXXXXXXXTSLKPLLFSSNASVIIS 326
+ ++DR + E + P L +N++V++S
Sbjct: 230 -----MPKDDREAQSICE--------------------------RVTPRLSHANSAVVLS 258
Query: 327 VSRALF-MLAPLSKFREF------GMPHCLVKALQLSSTENRCIIVQMIAYYASIDPEAF 379
+ L + LSK ++ + LV L + E + + ++ I PE
Sbjct: 259 AVKVLMKFMEMLSKDLDYYGTLLKKLAPPLVTLLS-AEPELQYVALRNINLIVQKRPEIL 317
Query: 380 ASLYRSFLPTADDDPIVGSYKLTIISLLITDKNVKDIIHELKYYITTYRDPAIVKKALST 439
+ F +D V KL I+ L + N+ ++ ELK Y T D V+KA+
Sbjct: 318 KHEMKVFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKEYATEV-DVDFVRKAVRA 376
Query: 440 LVVCAHNSNAFSAHIMKWLLSFMENDNLTDSEVTSEYVNVIRHLIQINPSKNLSVMLKLS 499
+ CA + + LL ++ + V E + VI+ + + P+K SV+ L
Sbjct: 377 IGRCAIKVEQSAERCVSTLLDLIQT---KVNYVVQEAIVVIKDIFRKYPNKYESVIATLC 433
Query: 500 QIITETDNLSAYAKAGIIWLFGEYIHVEPRI--VPDVLRKLIPKFADESTEARLQILILA 557
+ + D A+A +IW+ GEY RI ++L + F DEST+ +LQ+L
Sbjct: 434 ENLDSLD--EPEARAAMIWIVGEYAE---RIDNADELLESFLEGFHDESTQVQLQLLTAI 488
Query: 558 AKLLSFDIDRCESDYDFEQSRIAHLYDAVMYLAKFD-DDFDIRDK 601
KL + + + L V+ LA D D+ D+RD+
Sbjct: 489 VKL-----------FLKKPTETQELVQQVLSLATQDSDNPDLRDR 522
>Hs22027651 [U] KOG1061 Vesicle coat complex AP-1/AP-2/AP-4 beta subunit
Length = 949
Score = 140 bits (352), Expect = 1e-32
Identities = 138/585 (23%), Positives = 261/585 (44%), Gaps = 80/585 (13%)
Query: 32 ESSYTQYSKSIDPEALTRLLSSRNSREVKDAMKRVMSLMATNDPTVDLKSMFADILKNIS 91
+S Y +K + L L+S + K+A+K+V++ M D+ ++F D++ +
Sbjct: 3 DSKYFTTTKKGEIFELKAELNSDKKEKKKEAVKKVIASMTVGK---DVSALFPDVVNCMQ 59
Query: 92 SEDVKVKRMVCIYLLRFAESDPNVALLSVNTIQKNLQDRDPEAKALALKALSDINVASLY 151
++++++K++V +YL+ +A+S P++A+++VNT K+ +D +P +ALA++ + I V +
Sbjct: 60 TDNLELKKLVYLYLMNYAKSQPDMAIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDKIT 119
Query: 152 PITLQSVKKCVSDASPLVRATSAMTLFKLFQDSKSHDEEDDVRRHDLVPLLQELLADPDP 211
+ ++KC+ D P VR T+A+ + KL D + ED + L++L++D +P
Sbjct: 120 EYLCEPLRKCLKDEDPYVRKTAAVCVAKL-HDINAQLVED----QGFLDTLKDLISDSNP 174
Query: 212 LVISCTLVVLQNCLPDR-----LDLLHGHFRRYCAVLPSLSHWAQSLLVEMFIRYSKHFI 266
+V++ + L LDL + L + W Q +++ Y
Sbjct: 175 MVVANAVAALSEIAESHPSSNLLDLNPQSINKLLTALNECTEWGQIFILDCLANY----- 229
Query: 267 KRPVFVNREDRSETPLPETPELVDSWFLEANXXXXXXXXXXXXTSLKPLLFSSNASVIIS 326
+ ++DR + E + P L +N++V++S
Sbjct: 230 -----MPKDDREAQSICE--------------------------RVTPRLSHANSAVVLS 258
Query: 327 VSRALF-MLAPLSKFREF------GMPHCLVKALQLSSTENRCIIVQMIAYYASIDPEAF 379
+ L + LSK ++ + LV L + E + + ++ I PE
Sbjct: 259 AVKVLMKFMEMLSKDLDYYGTLLKKLAPPLVTLLS-AEPELQYVALRNINLIVQKRPEIL 317
Query: 380 ASLYRSFLPTADDDPIVGSYKLTIISLLITDKNVKDIIHELKYYITTYRDPAIVKKALST 439
+ F +D V KL I+ L + N+ ++ ELK Y T D V+KA+
Sbjct: 318 KHEMKVFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKEYATEV-DVDFVRKAVRA 376
Query: 440 LVVCAHNSNAFSAHIMKWLLSFMENDNLTDSEVTSEYVNVIRHLIQINPSKNLSVMLKLS 499
+ CA + + LL ++ + V E + VI+ + + P+K SV+ L
Sbjct: 377 IGRCAIKVEQSAERCVSTLLDLIQT---KVNYVVQEAIVVIKDIFRKYPNKYESVIATLC 433
Query: 500 QIITETDNLSAYAKAGIIWLFGEYIHVEPRI--VPDVLRKLIPKFADESTEARLQILILA 557
+ + D A+A +IW+ GEY RI ++L + F DEST+ +LQ+L
Sbjct: 434 ENLDSLD--EPEARAAMIWIVGEYAE---RIDNADELLESFLEGFHDESTQVQLQLLTAI 488
Query: 558 AKLLSFDIDRCESDYDFEQSRIAHLYDAVMYLAKFD-DDFDIRDK 601
KL + + + L V+ LA D D+ D+RD+
Sbjct: 489 VKL-----------FLKKPTETQELVQQVLSLATQDSDNPDLRDR 522
>At4g23460 [U] KOG1061 Vesicle coat complex AP-1/AP-2/AP-4 beta subunit
Length = 893
Score = 138 bits (347), Expect = 4e-32
Identities = 127/540 (23%), Positives = 241/540 (44%), Gaps = 64/540 (11%)
Query: 32 ESSYTQYSKSIDPEALTRLLSSRNSREVKDAMKRVMSLMATNDPTVDLKSMFADILKNIS 91
+S Y +K + L L+S+ + KDA+K+V++ M D+ S+F D++ +
Sbjct: 5 DSKYFSTTKKGEIPELKEELNSQYKDKRKDAVKKVIAAMTVGK---DVSSLFTDVVNCMQ 61
Query: 92 SEDVKVKRMVCIYLLRFAESDPNVALLSVNTIQKNLQDRDPEAKALALKALSDINVASLY 151
+E++++K++V +YL+ +A+S P++A+L+VNT K+ QD +P +ALA++ + I V +
Sbjct: 62 TENLELKKLVYLYLINYAKSQPDLAILAVNTFVKDSQDPNPLIRALAVRTMGCIRVDKIT 121
Query: 152 PITLQSVKKCVSDASPLVRATSAMTLFKLFQDSKSHDEEDDVRRHDLVPLLQELLADPDP 211
++KC+ D P VR T+A+ + KLF D + ED + L++L++D +P
Sbjct: 122 EYLCDPLQKCLKDDDPYVRKTAAICVAKLF-DINAELVED----RGFLEALKDLISDNNP 176
Query: 212 LVISCTLVVL----QNCLPDRLDLLHGHFRRYCAVLPSLSHWAQSLLVEMFIRYSKHFIK 267
+V++ + L +N ++ + L + W Q +++ RY
Sbjct: 177 MVVANAVAALAEIQENSTSPIFEINSTILTKLLTALNECTEWGQVFILDALSRY------ 230
Query: 268 RPVFVNREDRSETPLPETPELVDSWFLEANXXXXXXXXXXXXTSLKPLLFSSNASVIISV 327
++ P E +V+ + P L +N +V++S
Sbjct: 231 ---------KASDP-REAENIVE--------------------RVTPRLQHANCAVVLSA 260
Query: 328 SRALFMLAPLSKFREFGMPHCLVKA-----LQLSSTENRCIIVQMIAYYASIDPEAFASL 382
+ + L + C A L + E + + ++ I P A
Sbjct: 261 VKMILQQMELITSTDVIRNLCKKMAPPLVTLLSAEPEIQYVALRNINLIVQKRPTILAHE 320
Query: 383 YRSFLPTADDDPIVGSYKLTIISLLITDKNVKDIIHELKYYITTYRDPAIVKKALSTLVV 442
+ F +D V KL I+ L +D+N+ ++ E K Y T D V+KA+ +
Sbjct: 321 IKVFFCKYNDPIYVKMEKLEIMIKLASDRNIDQVLLEFKEYATEV-DVDFVRKAVRAIGR 379
Query: 443 CAHNSNAFSAHIMKWLLSFMENDNLTDSEVTSEYVNVIRHLIQINPSKNLSVMLKLSQII 502
CA + + LL ++ + + V E + VI+ + + P+ S++ L + +
Sbjct: 380 CAIKLERAAERCISVLLELIK---IKVNYVVQEAIIVIKDIFRRYPNTYESIIATLCESL 436
Query: 503 TETDNLSAYAKAGIIWLFGEYIHVEPRI--VPDVLRKLIPKFADESTEARLQILILAAKL 560
D AKA +IW+ GEY RI ++L + F +E + +LQ+L KL
Sbjct: 437 DTLD--EPEAKASMIWIIGEYAE---RIDNADELLESFLENFPEEPAQVQLQLLTATVKL 491
>SPBC947.02 [U] KOG1061 Vesicle coat complex AP-1/AP-2/AP-4 beta subunit
Length = 683
Score = 137 bits (346), Expect = 5e-32
Identities = 123/541 (22%), Positives = 247/541 (44%), Gaps = 60/541 (11%)
Query: 29 RIGESSYTQYSKSIDPEALTRLLSSRNSREVKDAMKRVMSLMATNDPTVDLKSMFADILK 88
++ +SS + K + L + L S+ + E DA+KR ++ M D+ S+F D+LK
Sbjct: 4 KLFQSSRFKAFKKSETSELQKGLVSQYAYERIDAVKRTIAAMTVGK---DVSSLFPDVLK 60
Query: 89 NISSEDVKVKRMVCIYLLRFAESDPNVALLSVNTIQKNLQDRDPEAKALALKALSDINVA 148
N+++ D+ +K++V +YL+ +A++ P++ +L+VNT K+ ++ +P +ALA++ + I V
Sbjct: 61 NLATRDITLKKLVYLYLINYAKTHPDLCILAVNTFVKDSEEYNPTLRALAIRTMGCIRVN 120
Query: 149 SLYPITLQSVKKCVSDASPLVRATSAMTLFKLFQDSKSHDEEDDVRRHDLVPLLQELLAD 208
+ ++K + D P VR +A+ + K++ + + + + LQ L++D
Sbjct: 121 KIIGYLADPLRKALKDEHPYVRKAAAVCVVKMYDLDREY-----CASNGFIEQLQALVSD 175
Query: 209 PDPLVIS---CTLVVLQNCLPDR--LDLLHGHFRRYCAVLPSLSHWAQSLLVEMFIRYSK 263
P+P+V++ +L + + P++ ++++ R L + W + ++ R+
Sbjct: 176 PNPVVVANAVRSLAEIHDQDPEKGYFNVVYTMTDRLMVALSECNEWGRITILNSLARFRT 235
Query: 264 HFIKRPVFVNREDRSETPLPETPELVDSWFLEANXXXXXXXXXXXXTSLKPLLFSSNASV 323
IK +V + P +N+ V
Sbjct: 236 SDIKEAEYVCER------------------------------------VVPQFQHANSGV 259
Query: 324 IISVSRALFMLAPL--SKFREFGMPHCLVKALQLSSTEN--RCIIVQMIAYYASIDPEAF 379
++S + + + PL S F +F L L ST++ + + ++ I P F
Sbjct: 260 VLSAVKVIMVHIPLFSSDFTDFLYKKMAPPLLTLLSTDSEIQYVALRNINLILQKRPSIF 319
Query: 380 ASLYRSFLPTADDDPIVGSYKLTIISLLITDKNVKDIIHELKYYITTYRDPAIVKKALST 439
R F +D + KL II++L D+N+ + I EL+ Y++ + VK+ +
Sbjct: 320 DVKTRVFFCKYNDPLYIKMEKLKIITMLACDENINETISELRAYVSEV-ELEFVKQTIKC 378
Query: 440 LVVCAHNSNAFSAHIMKWLLSFMENDNLTDSEVTSEYVNVIRHLIQINPSKNLSVMLKLS 499
L A + I + F+E L S + E V+ +++ P K ++ LS
Sbjct: 379 LGDVALK---VPSVINDCISIFLEIYELNISYMVQEVTVVMETVLRKYPQKIDLLLPYLS 435
Query: 500 QIITETDNLSAYAKAGIIWLFGEYIHVEPRIVPDVLRKLIPKFADESTEARLQILILAAK 559
++I E + A++ + W+ GE+ HV P +L ++I ADE + +L +L K
Sbjct: 436 RVIEELGD--PRARSSMAWILGEFSHVIP-TSSKLLSEMISTMADEDLQIQLALLTAVVK 492
Query: 560 L 560
L
Sbjct: 493 L 493
>At4g11380 [U] KOG1061 Vesicle coat complex AP-1/AP-2/AP-4 beta subunit
Length = 894
Score = 136 bits (343), Expect = 1e-31
Identities = 126/540 (23%), Positives = 241/540 (44%), Gaps = 64/540 (11%)
Query: 32 ESSYTQYSKSIDPEALTRLLSSRNSREVKDAMKRVMSLMATNDPTVDLKSMFADILKNIS 91
+S Y +K + L L+S+ + KDA+K+V++ M D+ S+F D++ +
Sbjct: 5 DSKYFSTTKKGEIPELKEELNSQYKDKRKDAVKKVIAAMTVGK---DVSSLFTDVVNCMQ 61
Query: 92 SEDVKVKRMVCIYLLRFAESDPNVALLSVNTIQKNLQDRDPEAKALALKALSDINVASLY 151
+E++++K++V +YL+ +A+S P++A+L+VNT K+ QD +P +ALA++ + I V +
Sbjct: 62 TENLELKKLVYLYLINYAKSQPDLAILAVNTFVKDSQDPNPLIRALAVRTMGCIRVDKIT 121
Query: 152 PITLQSVKKCVSDASPLVRATSAMTLFKLFQDSKSHDEEDDVRRHDLVPLLQELLADPDP 211
++KC+ D P VR T+A+ + KLF D + ED + L++L++D +P
Sbjct: 122 EYLCDPLQKCLKDDDPYVRKTAAICVAKLF-DINAELVED----RGFLEALKDLISDNNP 176
Query: 212 LVISCTLVVL----QNCLPDRLDLLHGHFRRYCAVLPSLSHWAQSLLVEMFIRYSKHFIK 267
+V++ + L +N ++ + L + W Q +++ +Y
Sbjct: 177 MVVANAVAALAEIQENSSSPIFEINSTTLTKLLTALNECTEWGQVFILDALSKY------ 230
Query: 268 RPVFVNREDRSETPLPETPELVDSWFLEANXXXXXXXXXXXXTSLKPLLFSSNASVIISV 327
++ P E +V+ + P L +N +V++S
Sbjct: 231 ---------KAADP-REAENIVE--------------------RVTPRLQHANCAVVLSA 260
Query: 328 SRALFMLAPLSKFREFGMPHCLVKA-----LQLSSTENRCIIVQMIAYYASIDPEAFASL 382
+ + L + C A L + E + + ++ I P A
Sbjct: 261 VKMILQQMELITSTDVIRNLCKKMAPPLVTLLSAEPEIQYVALRNINLIVQKRPTILAHE 320
Query: 383 YRSFLPTADDDPIVGSYKLTIISLLITDKNVKDIIHELKYYITTYRDPAIVKKALSTLVV 442
+ F +D V KL I+ L +D+N+ ++ E K Y T D V+KA+ +
Sbjct: 321 IKVFFCKYNDPIYVKMEKLEIMIKLASDRNIDQVLLEFKEYATEV-DVDFVRKAVRAIGR 379
Query: 443 CAHNSNAFSAHIMKWLLSFMENDNLTDSEVTSEYVNVIRHLIQINPSKNLSVMLKLSQII 502
CA + + LL ++ + + V E + VI+ + + P+ S++ L + +
Sbjct: 380 CAIKLERAAERCISVLLELIK---IKVNYVVQEAIIVIKDIFRRYPNTYESIIATLCESL 436
Query: 503 TETDNLSAYAKAGIIWLFGEYIHVEPRI--VPDVLRKLIPKFADESTEARLQILILAAKL 560
D AKA +IW+ GEY RI ++L + F +E + +LQ+L KL
Sbjct: 437 DTLD--EPEAKASMIWIIGEYAE---RIDNADELLESFLENFPEEPAQVQLQLLTATVKL 491
>7293642 [U] KOG1061 Vesicle coat complex AP-1/AP-2/AP-4 beta subunit
Length = 921
Score = 135 bits (339), Expect = 3e-31
Identities = 125/545 (22%), Positives = 247/545 (44%), Gaps = 71/545 (13%)
Query: 32 ESSYTQYSKSIDPEALTRLLSSRNSREVKDAMKRVMSLMATNDPTVDLKSMFADILKNIS 91
+S Y +K + L L++ + K+A+K+V++ M D+ ++F D++ +
Sbjct: 3 DSKYFTTTKKGEIFELKSELNNDKKEKKKEAVKKVIASMTVGK---DVSALFPDVVNCMQ 59
Query: 92 SEDVKVKRMVCIYLLRFAESDPNVALLSVNTIQKNLQDRDPEAKALALKALSDINVASLY 151
++++++K++V +YL+ +A+S P++A+++VNT K+ +D +P +ALA++ + I V +
Sbjct: 60 TDNLELKKLVYLYLMNYAKSQPDMAIMAVNTFVKDCEDSNPLIRALAVRTMGCIRVDKIT 119
Query: 152 PITLQSVKKCVSDASPLVRATSAMTLFKLFQDSKSHDEEDDVRRHDLVPLLQELLADPDP 211
+ ++KC+ D P VR T+A+ + KL+ S + E+ + L++LL+D +P
Sbjct: 120 EYLCEPLRKCLKDEDPYVRKTAAVCVAKLYDISATMVED-----QGFLDQLKDLLSDSNP 174
Query: 212 LVISCTLVVL-------QNCLPDRLDLLHGHFRRYCAVLPSLSHWAQSLLVEMFIRYSKH 264
+V++ + L Q+ P +++ + L + W Q +++ YS
Sbjct: 175 MVVANAVAALSEINEASQSGQP-LVEMNSVTINKLLTALNECTEWGQVFILDSLANYSP- 232
Query: 265 FIKRPVFVNREDRSETPLPETPELVDSWFLEANXXXXXXXXXXXXTSLKPLLFSSNASVI 324
+++R + E + P L +NA+V+
Sbjct: 233 ---------KDEREAQSICE--------------------------RITPRLAHANAAVV 257
Query: 325 ISVSRALF-MLAPLSKFREF------GMPHCLVKALQLSSTENRCIIVQMIAYYASIDPE 377
+S + L +L LS +F + LV L S E + + ++ I P+
Sbjct: 258 LSAVKVLMKLLEMLSSDSDFCATLTKKLAPPLVTLLS-SEPEVQYVALRNINLIVQKRPD 316
Query: 378 AFASLYRSFLPTADDDPIVGSYKLTIISLLITDKNVKDIIHELKYYITTYRDPAIVKKAL 437
+ F +D V KL I+ L N+ ++ ELK Y T D V+KA+
Sbjct: 317 ILKHEMKVFFVKYNDPIYVKLEKLDIMIRLANQSNIAQVLSELKEYATEV-DVDFVRKAV 375
Query: 438 STLVVCAHNSNAFSAHIMKWLLSFMENDNLTDSEVTSEYVNVIRHLIQINPSKNLSVMLK 497
+ CA + + LL ++ + V E + VI+ + + P+K S++
Sbjct: 376 RAIGRCAIKVEPSAERCVSTLLDLIQT---KVNYVVQEAIVVIKDIFRKYPNKYESIIST 432
Query: 498 LSQIITETDNLSAYAKAGIIWLFGEYIHVEPRI--VPDVLRKLIPKFADESTEARLQILI 555
L + + D A+A ++W+ GEY RI ++L + F DE+ + +LQ+L
Sbjct: 433 LCENLDTLD--EPEARASMVWIIGEYAE---RIDNADELLDSFLEGFQDENAQVQLQLLT 487
Query: 556 LAAKL 560
KL
Sbjct: 488 AVVKL 492
>YKL135c [U] KOG1061 Vesicle coat complex AP-1/AP-2/AP-4 beta subunit
Length = 726
Score = 113 bits (283), Expect = 1e-24
Identities = 119/530 (22%), Positives = 224/530 (41%), Gaps = 71/530 (13%)
Query: 51 LSSRNSREVKDAMKRVMSLMATNDPTVDLKSMFADILKNISSEDVKVKRMVCIYLLRFAE 110
L S+ + KDA+K+ + M D+ S+F D+LKNI++ DV+ K++V +Y++ +AE
Sbjct: 35 LVSQYPQTRKDAIKKTIQQMTLGK---DVSSLFPDVLKNIATIDVEQKKLVYLYVMNYAE 91
Query: 111 SDPNVALLSVNTIQKNLQDRDPEAKALALKALSDINVASLYPITLQSVKKCVSDASPLVR 170
+ P + +L+VNT + QD +P + +A++ +S I V + +++ + D + VR
Sbjct: 92 THPELCILAVNTFITDAQDPNPLIRCMAIRTMSMIRVDKILEYIETPLRRTLHDDNAYVR 151
Query: 171 ATSAMTLFKLFQDSKSHDEEDDVRRHDLVPLLQELLADPDPLVI---SCTLVVLQNCLPD 227
T+ + + KLFQ +K E V V L L D +PLVI + L+ + N D
Sbjct: 152 KTAVICVAKLFQLNKDLCVELGV-----VEDLVNALDDSNPLVIANATAALIEIHNMDMD 206
Query: 228 RLD---LLHGHFRRYCAVLPSLSHWAQSLLVEMFIRYS-KHFIKRPVFVNREDRSETPLP 283
+D L+ H ++ L + WA+ +++ YS K ++ ++R
Sbjct: 207 AVDLSSLIQSHVSQFLLALNECTEWARIIILGTLSEYSAKDSLEAQDIIDR--------- 257
Query: 284 ETPELVDSWFLEANXXXXXXXXXXXXTSLKPLLFSSNASVIISVSRALFMLAPLSKFREF 343
V + N +L + +SSN+ ++ +S A
Sbjct: 258 -----VTAHLQHVNPAVVLATIKVIVRNLPQIEYSSNSLIMKRLSSAFV----------- 301
Query: 344 GMPHCLVKALQLSSTENRCIIVQMIAYYASIDPEAFASLYRSFLPTADDDPIVGSYKLTI 403
+L + E + + ++ I PE R F +D V K+ I
Sbjct: 302 --------SLMSTPPEMQYVALKNIRIILEKYPELLTKELRIFYVKFNDPLYVKLEKIDI 353
Query: 404 ISLLITDKNVKD---IIHELKYYITTYRDPAIVKKALSTL--VVCAHNSNAFSAHIMKWL 458
+ L+ N+K ++ ELK Y Y +P V +A+ L + + +F + ++ L
Sbjct: 354 LVRLVDPSNLKQCTLLLTELKEYAMEY-EPEFVSRAIQALSQLGIKYAQESFVSKVLDIL 412
Query: 459 LSFMENDNLTDSEVTSEYVNVIRHLIQINPSKNLSVMLKLSQIITETDN-----LSAYAK 513
L +E + + +++RH N + ++ + N S AK
Sbjct: 413 LELLERQDTIKDDCCISLCDLLRHC-----PGNDKMAKQVCAVFNTWSNPEVLLQSDIAK 467
Query: 514 AGIIWLFGEYIHVEPRIVPDVLRKL---IPKFADESTEARLQILILAAKL 560
+WL G++ P D+ K+ I F E ++ +L+ +L
Sbjct: 468 CNYVWLLGQH----PNNFSDLESKINIFIENFVQEEALTQMSLLMTIVRL 513
>SPBC2G2.06c [U] KOG1061 Vesicle coat complex AP-1/AP-2/AP-4 beta subunit
Length = 677
Score = 107 bits (268), Expect = 5e-23
Identities = 116/515 (22%), Positives = 215/515 (41%), Gaps = 63/515 (12%)
Query: 60 KDAMKRVMSL---MATNDPTVDLKSMFADILKNISSEDVKVKRMVCIYLLRFAESDPNVA 116
K A KR+ +L +A D+ S+F ++ ++ S ++++K++ +YL +A P A
Sbjct: 26 KSANKRISALKKAIAGISYGYDMSSLFPSVISSMESNNLELKKLCYLYLKIYASVKPTEA 85
Query: 117 LLSVNTIQKNLQDRDPEAKALALKALSDINVASLYPITLQSVKKCVSDASPLVRATSAMT 176
+V I ++ +P ++LAL+ L+ +N+ + + + + + + D P VR T+A+
Sbjct: 86 KRAVKLILNDIYSSNPMIRSLALRTLTSVNIKNFWVAAMDPIVRLLDDTDPYVRKTAAIG 145
Query: 177 LFKLFQDSKSHDEEDDVRRHDLVPLLQELLADPDPLVISCTLVVLQNCLPD----RLDLL 232
+ KL+ K E + H L+E+L+D +V++ +L L N + +L
Sbjct: 146 IAKLYSYDKKMVESSGLIDH-----LKEMLSDESSVVVANSLAALMNIVNSSTGFKLTFS 200
Query: 233 HGHFRRYCAVLPSLSHWAQSLLVEMFIRYSKHFIKRPVFVNREDRSETPLPETPELVDSW 292
+ L S W Q +++ I Y +P+ P +S+
Sbjct: 201 REISNKLVKSLTDCSEWLQVAILDALIFY--------------------VPQKPGEAESF 240
Query: 293 FLEANXXXXXXXXXXXXTSLKPLLFSSNASVIISVSRALFMLAPLSK----FREFGM--P 346
+ P L NA+V + + + L K +E+ M
Sbjct: 241 ----------------AERISPWLQHGNAAVCMGAVKVILYLTNYMKDDNRVKEYFMKTQ 284
Query: 347 HCLVKALQLSSTENRCIIVQMIAYYASIDPEAFASLYRSFLPTADDDPIVGSYKLTIISL 406
LV L S+ + +I++ I PE FA+ F DD V KL I++
Sbjct: 285 PPLVTLLARKSSATQYVILRNIQIILEQCPEMFANDIHFFYCNFDDPIYVKLEKLDILTK 344
Query: 407 LITDKNVKDIIHELKYYITTYRDPAIVKKALSTLVVCAHNSNAFSAHIMKWLLSFMENDN 466
+ N+ I+ E Y + D +V+K++ + A + L+ M N
Sbjct: 345 IADIHNLDQILPEFVEYASEI-DVELVRKSVKCIGYLAIKIEERKNDCIDSLIELM---N 400
Query: 467 LTDSEVTSEYVNVIRHLIQINPSKNLSVMLKLSQIITETDNLSAYAKAGIIWLFGEYI-H 525
+ V E V VIR +++ P S++ L + + D AK+ +IW+ G+Y
Sbjct: 401 TKVTYVIQEAVIVIRDILRKYPGSYKSLVPILYENLDSLDEPD--AKSAVIWILGQYAEE 458
Query: 526 VEPRIVPDVLRKLIPKFADESTEARLQILILAAKL 560
+E I +L + F DE E +L +L K+
Sbjct: 459 IEDSIT--LLNDYLKGFFDEPLEIQLTLLTAVIKV 491
>At5g11490 [U] KOG1061 Vesicle coat complex AP-1/AP-2/AP-4 beta subunit
Length = 841
Score = 99.4 bits (246), Expect = 2e-20
Identities = 119/527 (22%), Positives = 227/527 (42%), Gaps = 87/527 (16%)
Query: 60 KDAMKRVMSLMATNDPTVDLKSMFADILKNISSEDVKVKRMVCIYLLRFAESDPNVALLS 119
+D K+V+S M +D+ S+F +++ ++ D+ +K+M +Y+ +A+ +P+++LL+
Sbjct: 45 RDLYKKVISYMTIG---IDVSSVFGEMVMCSATSDIVLKKMCYLYVGNYAKGNPDLSLLT 101
Query: 120 VNTIQKNLQDRDPEAKALALKALSDINVASLYPITLQSVKKCVSDASPLVRATSAMTLFK 179
+N +Q++ +D DP + LAL++L + V +L + + + D + VR + + K
Sbjct: 102 INFLQRDCKDEDPMIRGLALRSLCSLRVPNLVEYLVGPLGSGLKDNNSYVRTIAVTGVLK 161
Query: 180 LFQDSKSHDEEDDVRRHDLVPLLQELLADPDPLVISCTLVVLQNCLPDRLDLLHGHFRRY 239
L+ S S + D L +L D D V++ L LQ + L H
Sbjct: 162 LYHISPSTCIDADFP----ATLKSLMLHDSDAQVVANCLSALQ----EIWSLEASHSEEA 213
Query: 240 CAVLPSL----------------SHWAQSLLVEMFIRYSKHFIKRPVFVNREDRSETPLP 283
C SL + WAQ L++E+ ++Y
Sbjct: 214 CREKESLLSKPVIYYFLNRIKEFNEWAQCLILELAVKYVP-------------------S 254
Query: 284 ETPELVDSWFLEANXXXXXXXXXXXXTSLKPLLFSSNASVIISVSRALFMLAPLSK---- 339
++ ++ D L L+ L +N +V+++ + +F+ LS
Sbjct: 255 DSNDIFDIMNL-----------------LEDRLQHANGAVVLATVK-VFLQLTLSMTDVH 296
Query: 340 ---FREFGMPHCLVKALQLSSTENRCIIVQMIAYYASIDPEAFASLYRSFLPTADDDPIV 396
+ P L+ + S E I+ + P FA+ Y+ F ++ V
Sbjct: 297 QQVYERIKSP--LLTLVSSGSPEQSYAILSHLHLLVVRAPFIFAADYKHFYCQYNEPSYV 354
Query: 397 GSYKLTIISLLITDKNVKDIIHELKYYITTYRDPAIVK---KALSTLVVCAHNSNAFSAH 453
KL +++ + + N +I+ EL Y D AI + +A+ + + ++ NA
Sbjct: 355 KKLKLEMLTAVANESNTYEIVTELCEYAANV-DIAIARESIRAVGKIALQQYDVNA---- 409
Query: 454 IMKWLLSFMENDNLTDSEVTSEYVNVIRHLIQINPSKNLSVMLKLSQIITETDNLSAYAK 513
I+ LL F+E + VT+E + +++ L++ P + + + I ++ AK
Sbjct: 410 IVDRLLQFLE---MEKDYVTAETLVLVKDLLRKYPQWSHDCISVVGGISSKNIQ-EPKAK 465
Query: 514 AGIIWLFGEYIHVEPRIVPDVLRKLIPKFADE-STEARLQILILAAK 559
A +IW+ GEY + P VL LI + +E S E RL +L A K
Sbjct: 466 AALIWMLGEYAQ-DMSDAPYVLENLIENWEEEHSAEVRLHLLTAAMK 511
>Hs5729742 [U] KOG1061 Vesicle coat complex AP-1/AP-2/AP-4 beta subunit
Length = 739
Score = 90.5 bits (223), Expect = 9e-18
Identities = 113/519 (21%), Positives = 213/519 (40%), Gaps = 83/519 (15%)
Query: 60 KDAMKRVMSLMATNDPTVDLKSMFADILKNISSEDVKVKRMVCIYLLRFAESDPNVALLS 119
++ ++RV+ M +D+ +F +++K ++ D+ K++V +Y+ +A P++ALL+
Sbjct: 30 RNVIQRVIRYMTQG---LDMSGVFMEMVKASATVDIVQKKLVYLYMCTYAPLKPDLALLA 86
Query: 120 VNTIQKNLQDRDPEAKALALKALSDINVASLYPITLQSVKKCVSDASPLVRATSAMTLFK 179
+NT+ K+ D +P + LAL+++ + + + Q + + D + VR + K
Sbjct: 87 INTLCKDCSDPNPMVRGLALRSMCSLRMPGVQEYIQQPILNGLRDKASYVRRVVVLGCAK 146
Query: 180 LFQDSKSHDEEDDVRRHDLVPLLQELLADPDPLVISCTLVVLQNCLPD------RLDLLH 233
+ + D E D LV L LL D DP+V+ L L+ L + H
Sbjct: 147 M--HNLHGDSEVD---GALVNELYSLLRDQDPIVVVNCLRSLEEILKQEGGVVINKPIAH 201
Query: 234 GHFRRYCAVLPSLSHWAQSLLVEMFIRYSKHFIKRPVFVNREDRSETPLPETPELVDSWF 293
R + L W Q+ ++ +RY + RSE L + L+DS+
Sbjct: 202 HLLNR----MSKLDQWGQAEVLNFLLRY-------------QPRSEEELFDILNLLDSF- 243
Query: 294 LEANXXXXXXXXXXXXTSLKPLLFSSNASVIISVSRALFMLAPLSKFREFGMPH----CL 349
L SS+ V++ ++ +LA + PH L
Sbjct: 244 ----------------------LKSSSPGVVMGATKLFLILAKM-------FPHVQTDVL 274
Query: 350 VKA----LQLSSTENRCIIVQMIAYYASI---DPEAFASLYRSFLPTADDDPIVGSYKLT 402
V+ L S+E+R + + + I P F+S Y+ F + + + K+
Sbjct: 275 VRVKGPLLAACSSESRELCFVALCHVRQILHSLPGHFSSHYKKFFCSYSEPHYIKLQKVE 334
Query: 403 IISLLITDKNVKDIIHELKYYITTYRDPAIVKKALSTLVVCAHNSNAFSAHIMKWLLSFM 462
++ L+ D+NV+ ++ EL+ Y T + A+ + A I+ LL
Sbjct: 335 VLCELVNDENVQQVLEELRGYCTDV-SADFAQAAIFAIGGIARTYTDQCVQILTELL--- 390
Query: 463 ENDNLTDSEVTSEYVNVIRHLIQINPSKNLSVMLKLSQIITETDNLSAYAKAGIIWLFGE 522
L +T+ V R L+ + P +V L E + + K +IWL G
Sbjct: 391 ---GLRQEHITTVVVQTFRDLVWLCPQCTEAVCQALPG--CEENIQDSEGKQALIWLLGV 445
Query: 523 YIHVEPRIVPDVLRKLIPKFADESTEA-RLQILILAAKL 560
+ P P VL + E+ A ++++L + +L
Sbjct: 446 HGERIPN-APYVLEDFVENVKSETFPAVKMELLTASLRL 483
>Hs18596139 [U] KOG1061 Vesicle coat complex AP-1/AP-2/AP-4 beta subunit
Length = 863
Score = 86.7 bits (213), Expect = 1e-16
Identities = 53/190 (27%), Positives = 107/190 (55%), Gaps = 8/190 (4%)
Query: 32 ESSYTQYSKSIDPEALTRLLSSRNSREVKDAMKRVMSLMATNDPTVDLKSMFADILKNIS 91
+S Y +K + L LS+ + K+A+K+V++++ D+ S+F DI+ +
Sbjct: 3 DSKYFTTNKKAEIFELKAELSNEKKEKRKEAVKKVIAVITVGK---DVSSVFPDIVNCMQ 59
Query: 92 SEDVKVKRMVCIYLLRFAESDPNVALLSVNTIQKNLQDRDPEAKALALKALSDINVASLY 151
++++K+K++V +YL+ +A S P++A+++VN+ K+ +D + +ALA++ + I V +
Sbjct: 60 TDNLKLKKLVYLYLMNYANSQPDMAIIAVNSFVKDCEDPNLLIRALAVRTMGCIWVDKIT 119
Query: 152 PITLQSVKKCVSDASPLVRATSAMTLFKLFQDSKSHDEEDDVRRHDLVPLLQELLADPDP 211
+ + KC+ D P VR T+A+ + KL D + ED + L L+AD +P
Sbjct: 120 EYLSEPLLKCLEDEDPYVRKTAAVCVAKL-HDINAQMVED----QGFLDSLWGLIADSNP 174
Query: 212 LVISCTLVVL 221
+V++ + L
Sbjct: 175 MVVANAVAAL 184
>YDR238c [U] KOG1058 Vesicle coat complex COPI beta subunit
Length = 973
Score = 60.8 bits (146), Expect = 8e-09
Identities = 111/525 (21%), Positives = 205/525 (38%), Gaps = 83/525 (15%)
Query: 33 SSYTQYSKSIDPEALTRLLSS--------RNSREVK-DAMKRVMSLMATNDPTVDLKSMF 83
SS Y+ DP SS + S E K D MK ++ M +P +L
Sbjct: 5 SSQPAYTLVFDPSPSMETYSSTDFQKALEKGSDEQKIDTMKSILVTMLEGNPMPELLMHI 64
Query: 84 ADILKNISSEDVKVKRMVCIY---LLRFAESDP--NVALLSVNTIQKNLQDRDPEAKALA 138
+ + S++ ++K+++ Y + + AE + +L N IQ +LQ + +
Sbjct: 65 IRFV--MPSKNKELKKLLYFYWEIVPKLAEDGKLRHEMILVCNAIQHDLQHPNEYIRGNT 122
Query: 139 LKALSDINVASLYPITLQSVKKCVSDASPLVRATSAMTLFKLFQDSKSHDEEDDVRRHDL 198
L+ L+ + A L + SV C+ VR + + +F +F+ S+ L
Sbjct: 123 LRFLTKLREAELLEQMVPSVLACLEYRHAYVRKYAILAVFSIFKVSEH-----------L 171
Query: 199 VPLLQELL-----ADPDPLVISCTLVVLQNCLPDRLDLLHGHFRRYCAVLPSLSHWAQSL 253
+P +E++ A+ DP+ + L DR + LH + A + +L Q++
Sbjct: 172 LPDAKEIINSFIVAETDPICKRNAFIGLAEL--DRENALH-YLENNIADIENLDPLLQAV 228
Query: 254 LVEMFIRYSKHFIKRPVFVNREDRSETPLPETPELVDSWFLEANXXXXXXXXXXXXTSLK 313
V+ R+D + TP + + L T+L
Sbjct: 229 FVQFI---------------RQDANRTPALKAQYIE---LLMELLSTTTSDEVIFETALA 270
Query: 314 PLLFSSNASVIISVSRALFMLAPLSKFREFGMPHCLVKALQLSSTENRCIIVQMIAYYAS 373
+ S+N +V++ L LA +++S + I++ I +
Sbjct: 271 LTVLSANPNVLVPAVNKLIDLA-----------------VKVSDNNIKLIVLDRIQDINA 313
Query: 374 IDPEAFASLYRSFLPTAD-DDPIVGSYKLTIISLLITDKNVKDIIHELKYYITTY----- 427
+ A L L + +D V S L I L T +N +D++ LK + T
Sbjct: 314 NNVGALEELTLDILRVLNAEDLDVRSKALDISMDLATSRNAEDVVQLLKKELQTTVNNPD 373
Query: 428 RDPAIVKKAL--STLVVCAHNSNAFSAHIMKWLLSFMENDNLTDSEVTSEYVNVIRHLIQ 485
+D A+ + L T+ A N +A ++ LL F+ + N S S + I+ +I+
Sbjct: 374 QDKAMQYRQLLIKTIRTVAVNFVEMAASVVSLLLDFIGDLN---SVAASGIIAFIKEVIE 430
Query: 486 INPSKNLSVMLKLSQIITETDNLSAYAKAGIIWLFGEYIHVEPRI 530
P +++ + Q + + + AY G +W+ GEY E I
Sbjct: 431 KYPQLRANILENMVQTLDKVRSAKAYR--GALWIMGEYAEGESEI 473
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.319 0.133 0.374
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 40,284,953
Number of Sequences: 60738
Number of extensions: 1603079
Number of successful extensions: 5025
Number of sequences better than 1.0e-05: 23
Number of HSP's better than 0.0 without gapping: 22
Number of HSP's successfully gapped in prelim test: 1
Number of HSP's that attempted gapping in prelim test: 4897
Number of HSP's gapped (non-prelim): 49
length of query: 792
length of database: 30,389,216
effective HSP length: 114
effective length of query: 678
effective length of database: 23,465,084
effective search space: 15909326952
effective search space used: 15909326952
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)