ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactI2530 good H KOG2698 Coenzyme transport and metabolism GTP cyclohydrolase I
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactI2530 854900 854166 -245
(245 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YGR267c [H] KOG2698 GTP cyclohydrolase I 380 e-106
SPAC17A5.13 [H] KOG2698 GTP cyclohydrolase I 287 1e-77
CE05795 [H] KOG2698 GTP cyclohydrolase I 252 3e-67
Hs4503949 [H] KOG2698 GTP cyclohydrolase I 249 2e-66
7291261 [H] KOG2698 GTP cyclohydrolase I 238 7e-63
7291259 [H] KOG2698 GTP cyclohydrolase I 238 7e-63
At3g07270 [H] KOG2698 GTP cyclohydrolase I 119 4e-27
>YGR267c [H] KOG2698 GTP cyclohydrolase I
Length = 243
Score = 380 bits (977), Expect = e-106
Identities = 191/240 (79%), Positives = 208/240 (86%), Gaps = 1/240 (0%)
Query: 5 HISHVSQIERRATPLNIRPASPYTLNPTVEKDGLSWPSIGXXXXXXXXXXXXQKRVGRIA 64
+I V +IER TPLNIRP SPYTLNP VE+DG SWPS+G ++R+ RI+
Sbjct: 3 NIQLVQEIERHETPLNIRPTSPYTLNPPVERDGFSWPSVGTRQRAEETEEEEKERIQRIS 62
Query: 65 DAVKTILSELGEDTEREGLLDTPTRYAKAMLYFTKGYQDNIMNDVIKNAVFEEDHDEMVI 124
A+KTIL+ELGED REGLLDTP RYAKAMLYFTKGYQ NIM+DVIKNAVFEEDHDEMVI
Sbjct: 63 GAIKTILTELGEDVNREGLLDTPQRYAKAMLYFTKGYQTNIMDDVIKNAVFEEDHDEMVI 122
Query: 125 VRDIEIFSLCEHHLVPFFGKVHIGYIPNKKVLGLSKLARLAEMYARRFQVQERLTKQIAM 184
VRDIEI+SLCEHHLVPFFGKVHIGYIPNKKV+GLSKLARLAEMYARR QVQERLTKQIAM
Sbjct: 123 VRDIEIYSLCEHHLVPFFGKVHIGYIPNKKVIGLSKLARLAEMYARRLQVQERLTKQIAM 182
Query: 185 ALSDILKPRGVAVVIEATHMCMVSRGVQKTGSSTVTSCMLGYLRESHKTREEFLNLLGRR 244
ALSDILKP GVAVV+EA+HMCMVSRG+QKTGSSTVTSCMLG R +HKTREEFL LLGRR
Sbjct: 183 ALSDILKPLGVAVVMEASHMCMVSRGIQKTGSSTVTSCMLGGFR-AHKTREEFLTLLGRR 241
>SPAC17A5.13 [H] KOG2698 GTP cyclohydrolase I
Length = 235
Score = 287 bits (734), Expect = 1e-77
Identities = 143/228 (62%), Positives = 178/228 (77%), Gaps = 5/228 (2%)
Query: 17 TPLNIRPAS-PYTLNPTVEKDGLSWPSIGXXXXXXXXXXXXQKRVGRIADAVKTILSELG 75
+PL ++PAS PT++ DGLSWP G +++V +I++A+ TIL LG
Sbjct: 11 SPLRMQPASLSGASTPTIDLDGLSWPCQGTQRRIDTAE---EEKVKKISNAISTILECLG 67
Query: 76 EDTEREGLLDTPTRYAKAMLYFTKGYQDNIMNDVIKNAVFEEDHDEMVIVRDIEIFSLCE 135
ED ER+GLL TP RYAKAMLYFTKGY+ N+ +VI AVF+EDH+EMVIVRDI++FSLCE
Sbjct: 68 EDPERQGLLGTPERYAKAMLYFTKGYEQNL-TEVINEAVFQEDHEEMVIVRDIDVFSLCE 126
Query: 136 HHLVPFFGKVHIGYIPNKKVLGLSKLARLAEMYARRFQVQERLTKQIAMALSDILKPRGV 195
HHLVPF GK+HIGYIP K+VLGLSKLAR+A M++RR QVQERLTKQ+A A+ +LKP+GV
Sbjct: 127 HHLVPFIGKIHIGYIPRKRVLGLSKLARIANMFSRRLQVQERLTKQVAQAIQAVLKPQGV 186
Query: 196 AVVIEATHMCMVSRGVQKTGSSTVTSCMLGYLRESHKTREEFLNLLGR 243
AVV+EATHMCMV RGV+K GSSTVTS + G + SHKTREEF L+G+
Sbjct: 187 AVVMEATHMCMVMRGVEKPGSSTVTSSLTGIFQRSHKTREEFFRLIGK 234
>CE05795 [H] KOG2698 GTP cyclohydrolase I
Length = 223
Score = 252 bits (644), Expect = 3e-67
Identities = 123/182 (67%), Positives = 150/182 (81%), Gaps = 1/182 (0%)
Query: 63 IADAVKTILSELGEDTEREGLLDTPTRYAKAMLYFTKGYQDNIMNDVIKNAVFEEDHDEM 122
+ +A ++I+ +GED R+GLL TP R AKAM+ FTKGY D + ++++ AVF+EDHDEM
Sbjct: 43 MCNAYQSIIQHVGEDINRQGLLKTPERAAKAMMAFTKGYDDQL-DELLNEAVFDEDHDEM 101
Query: 123 VIVRDIEIFSLCEHHLVPFFGKVHIGYIPNKKVLGLSKLARLAEMYARRFQVQERLTKQI 182
VIV+DIE+FSLCEHHLVPF GKVHIGYIPNKKVLGLSKLAR+ EM++RR QVQERLTKQI
Sbjct: 102 VIVKDIEMFSLCEHHLVPFMGKVHIGYIPNKKVLGLSKLARIVEMFSRRLQVQERLTKQI 161
Query: 183 AMALSDILKPRGVAVVIEATHMCMVSRGVQKTGSSTVTSCMLGYLRESHKTREEFLNLLG 242
A A+ ++P GVAVVIEA+HMCMV RGVQK +ST TSCMLG R+ KTREEFLNL+
Sbjct: 162 ATAMVQAVQPSGVAVVIEASHMCMVMRGVQKINASTTTSCMLGVFRDDPKTREEFLNLIN 221
Query: 243 RR 244
+R
Sbjct: 222 KR 223
>Hs4503949 [H] KOG2698 GTP cyclohydrolase I
Length = 250
Score = 249 bits (637), Expect = 2e-66
Identities = 122/179 (68%), Positives = 150/179 (83%), Gaps = 1/179 (0%)
Query: 63 IADAVKTILSELGEDTEREGLLDTPTRYAKAMLYFTKGYQDNIMNDVIKNAVFEEDHDEM 122
+A A +ILS LGE+ +R+GLL TP R A AM +FTKGYQ+ I +DV+ +A+F+EDHDEM
Sbjct: 71 LAAAYSSILSSLGENPQRQGLLKTPWRAASAMQFFTKGYQETI-SDVLNDAIFDEDHDEM 129
Query: 123 VIVRDIEIFSLCEHHLVPFFGKVHIGYIPNKKVLGLSKLARLAEMYARRFQVQERLTKQI 182
VIV+DI++FS+CEHHLVPF GKVHIGY+PNK+VLGLSKLAR+ E+Y+RR QVQERLTKQI
Sbjct: 130 VIVKDIDMFSMCEHHLVPFVGKVHIGYLPNKQVLGLSKLARIVEIYSRRLQVQERLTKQI 189
Query: 183 AMALSDILKPRGVAVVIEATHMCMVSRGVQKTGSSTVTSCMLGYLRESHKTREEFLNLL 241
A+A+++ L+P GV VV+EATHMCMV RGVQK S TVTS MLG RE KTREEFL L+
Sbjct: 190 AVAITEALRPAGVGVVVEATHMCMVMRGVQKMNSKTVTSTMLGVFREDPKTREEFLTLI 248
>7291261 [H] KOG2698 GTP cyclohydrolase I
Length = 308
Score = 238 bits (606), Expect = 7e-63
Identities = 115/182 (63%), Positives = 146/182 (80%), Gaps = 1/182 (0%)
Query: 63 IADAVKTILSELGEDTEREGLLDTPTRYAKAMLYFTKGYQDNIMNDVIKNAVFEEDHDEM 122
+A + + +L LGE+ +R+GL+ TP R AKAMLYFTKGY D + DV+ AVF+EDHDEM
Sbjct: 128 MARSYRLLLGGLGENPDRQGLIKTPERAAKAMLYFTKGY-DQSLEDVLNGAVFDEDHDEM 186
Query: 123 VIVRDIEIFSLCEHHLVPFFGKVHIGYIPNKKVLGLSKLARLAEMYARRFQVQERLTKQI 182
V+V+DIE+FS+CEHHLVPF+GKV IGY+P K+LGLSKLAR+ E+++RR QVQERLTKQI
Sbjct: 187 VVVKDIEMFSMCEHHLVPFYGKVSIGYLPCNKILGLSKLARIVEIFSRRLQVQERLTKQI 246
Query: 183 AMALSDILKPRGVAVVIEATHMCMVSRGVQKTGSSTVTSCMLGYLRESHKTREEFLNLLG 242
A+A++ ++P GVAVV+E HMCMV RGVQK S TVTS MLG R+ KTREEFLNL+
Sbjct: 247 AVAVTQAVQPAGVAVVVEGVHMCMVMRGVQKINSKTVTSTMLGVFRDDPKTREEFLNLVN 306
Query: 243 RR 244
+
Sbjct: 307 SK 308
>7291259 [H] KOG2698 GTP cyclohydrolase I
Length = 273
Score = 238 bits (606), Expect = 7e-63
Identities = 115/182 (63%), Positives = 146/182 (80%), Gaps = 1/182 (0%)
Query: 63 IADAVKTILSELGEDTEREGLLDTPTRYAKAMLYFTKGYQDNIMNDVIKNAVFEEDHDEM 122
+A + + +L LGE+ +R+GL+ TP R AKAMLYFTKGY D + DV+ AVF+EDHDEM
Sbjct: 93 MARSYRLLLGGLGENPDRQGLIKTPERAAKAMLYFTKGY-DQSLEDVLNGAVFDEDHDEM 151
Query: 123 VIVRDIEIFSLCEHHLVPFFGKVHIGYIPNKKVLGLSKLARLAEMYARRFQVQERLTKQI 182
V+V+DIE+FS+CEHHLVPF+GKV IGY+P K+LGLSKLAR+ E+++RR QVQERLTKQI
Sbjct: 152 VVVKDIEMFSMCEHHLVPFYGKVSIGYLPCNKILGLSKLARIVEIFSRRLQVQERLTKQI 211
Query: 183 AMALSDILKPRGVAVVIEATHMCMVSRGVQKTGSSTVTSCMLGYLRESHKTREEFLNLLG 242
A+A++ ++P GVAVV+E HMCMV RGVQK S TVTS MLG R+ KTREEFLNL+
Sbjct: 212 AVAVTQAVQPAGVAVVVEGVHMCMVMRGVQKINSKTVTSTMLGVFRDDPKTREEFLNLVN 271
Query: 243 RR 244
+
Sbjct: 272 SK 273
>At3g07270 [H] KOG2698 GTP cyclohydrolase I
Length = 466
Score = 119 bits (298), Expect = 4e-27
Identities = 72/182 (39%), Positives = 103/182 (56%), Gaps = 6/182 (3%)
Query: 63 IADAVKTILSELGEDTEREGLLDTPTRYAKAMLYFTKGYQDNIMNDVIKNAVFEEDHDEM 122
+ AV +IL LGED R+ L+ TPTR+ K ML F + + +N V E ++
Sbjct: 270 MVSAVVSILKSLGEDPLRKELIATPTRFLKWMLNFQRTNLEMKLNSFNPAKVNGEVKEKR 329
Query: 123 VIVR-DIEIFSLCEHHLVPFFGKVHIGYI----PNKKVLGLSKLARLAEMYARRFQVQER 177
+ ++ +S+CEHHL+PF+G VHIGY N +G S + + Y + QVQER
Sbjct: 330 LHCELNMPFWSMCEHHLLPFYGVVHIGYFCAEGSNPNPVGSSLMKAIVHFYGFKLQVQER 389
Query: 178 LTKQIAMALSDILKPRGVAVVIEATHMCMVSRGVQKTGSSTVTSCMLGYLRESHKTREEF 237
+T+QIA LS ++ V VV EA H CM+SRG++K GSST T +LG + R F
Sbjct: 390 MTRQIAETLSPLVGG-DVIVVAEAGHTCMISRGIEKFGSSTATIAVLGRFSSDNSARAMF 448
Query: 238 LN 239
L+
Sbjct: 449 LD 450
Score = 117 bits (292), Expect = 2e-26
Identities = 67/154 (43%), Positives = 98/154 (63%), Gaps = 13/154 (8%)
Query: 63 IADAVKTILSELGEDTEREGLLDTPTRYAKAMLYFTKGYQDNIMNDVIKNAVFEEDH-DE 121
I DAVK +L L ED REG+ TP R AKA+ T+GY+ + D +++A+F E DE
Sbjct: 35 IQDAVKLLLQGLHEDVNREGIKKTPFRVAKALREGTRGYKQKV-KDYVQSALFPEAGLDE 93
Query: 122 ----------MVIVRDIEIFSLCEHHLVPFFGKVHIGYIPN-KKVLGLSKLARLAEMYAR 170
+V+VRD++ +S CE L+PF K HIGY+P+ ++VLGLSK +R+ +++A+
Sbjct: 94 GVGQAGGVGGLVVVRDLDHYSYCESCLLPFHVKCHIGYVPSGQRVLGLSKFSRVTDVFAK 153
Query: 171 RFQVQERLTKQIAMALSDILKPRGVAVVIEATHM 204
R Q +RL I AL +KP GVAVV+E +H+
Sbjct: 154 RLQDPQRLADDICSALQHWVKPAGVAVVLECSHI 187
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.321 0.136 0.390
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,981,927
Number of Sequences: 60738
Number of extensions: 477401
Number of successful extensions: 1190
Number of sequences better than 1.0e-05: 7
Number of HSP's better than 0.0 without gapping: 7
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 1170
Number of HSP's gapped (non-prelim): 8
length of query: 245
length of database: 30,389,216
effective HSP length: 104
effective length of query: 141
effective length of database: 24,072,464
effective search space: 3394217424
effective search space used: 3394217424
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)