ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactI2594 good O KOG1358 Posttranslational modification, protein turnover, chaperones Serine palmitoyltransferase
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactI2594 875355 873691 -555
(555 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YMR296c [O] KOG1358 Serine palmitoyltransferase 629 e-180
SPBC18E5.02c [O] KOG1358 Serine palmitoyltransferase 289 7e-78
CE08323 [O] KOG1358 Serine palmitoyltransferase 264 3e-70
Hs5454084 [O] KOG1358 Serine palmitoyltransferase 251 2e-66
7303358 [O] KOG1358 Serine palmitoyltransferase 245 1e-64
At4g36480 [O] KOG1358 Serine palmitoyltransferase 227 3e-59
Hs4758668 [O] KOG1357 Serine palmitoyltransferase 155 1e-37
7298232 [O] KOG1357 Serine palmitoyltransferase 147 3e-35
7294669 [E] KOG1359 Glycine C-acetyltransferase/2-amino-3-ketobu... 147 5e-35
ECU02g0860 [O] KOG1358 Serine palmitoyltransferase 142 1e-33
YDR062w [O] KOG1357 Serine palmitoyltransferase 137 3e-32
At3g48780 [O] KOG1357 Serine palmitoyltransferase 137 4e-32
Hs7657118 [E] KOG1359 Glycine C-acetyltransferase/2-amino-3-keto... 137 6e-32
At5g23670 [O] KOG1357 Serine palmitoyltransferase 137 6e-32
CE13990 [O] KOG1357 Serine palmitoyltransferase 130 7e-30
ECU05g0730 [O] KOG1357 Serine palmitoyltransferase 127 6e-29
CE27380 [O] KOG1357 Serine palmitoyltransferase 120 5e-27
CE07246 [O] KOG1357 Serine palmitoyltransferase 120 5e-27
Hs4502025 [H] KOG1360 5-aminolevulinate synthase 114 5e-25
Hs4557299 [H] KOG1360 5-aminolevulinate synthase 110 4e-24
At3g48790 [O] KOG1357 Serine palmitoyltransferase 108 3e-23
SPAC2F3.09 [H] KOG1360 5-aminolevulinate synthase 107 4e-23
YDR232w [H] KOG1360 5-aminolevulinate synthase 104 3e-22
Hs18597111 [E] KOG1359 Glycine C-acetyltransferase/2-amino-3-ket... 100 1e-20
7291697 [H] KOG1360 5-aminolevulinate synthase 98 3e-20
At5g04620 [E] KOG1359 Glycine C-acetyltransferase/2-amino-3-keto... 90 8e-18
CE06500 [E] KOG1359 Glycine C-acetyltransferase/2-amino-3-ketobu... 83 1e-15
>YMR296c [O] KOG1358 Serine palmitoyltransferase
Length = 558
Score = 629 bits (1622), Expect = e-180
Identities = 318/554 (57%), Positives = 404/554 (72%), Gaps = 4/554 (0%)
Query: 6 NVPEVLPXXXXXXXXXXXXXXYLWFYFITFFKLIPGAHYVIDYVEKSHQDDPYRTFVEVL 65
++PEVLP YLW+YF IPG +++ Y++KSH DDPYRT VE+
Sbjct: 3 HIPEVLPKSIPIPAFIVTTSSYLWYYFNLVLTQIPGGQFIVSYIKKSHHDDPYRTTVEIG 62
Query: 66 LILYSIVYFLSKPKKKGAVD--QPKLSEKEIDNLXXXXXXXXXXXXXXRNE--WRLAKIP 121
LILY I+Y+LSKP++K ++ +P LS +EID L +E WR+AK P
Sbjct: 63 LILYGIIYYLSKPQQKKSLQAQKPNLSPQEIDALIEDWEPEPLVDPSATDEQSWRVAKTP 122
Query: 122 VIEGSGADNVINITRDNGKEAYASAFNLCSFNFLQLSKHPRVVEIAKEIIKNYGVGSCGP 181
V N I ITR+N +E Y + FNL S NFLQLS V E+ K IKNYGVG+CGP
Sbjct: 123 VTMEMPIQNHITITRNNLQEKYTNVFNLASNNFLQLSATEPVKEVVKTTIKNYGVGACGP 182
Query: 182 AGFYGNEDVHYNLEYDLASFFGTENSVLYGQDFCVSSSVIPAFTKRGDVIVADDKISVSS 241
AGFYGN+DVHY LEYDLA FFGT+ SVLYGQDFC + SV+PAFTKRGDVIVADD++S+
Sbjct: 183 AGFYGNQDVHYTLEYDLAQFFGTQGSVLYGQDFCAAPSVLPAFTKRGDVIVADDQVSLPV 242
Query: 242 QNALQLSRSTVYYYKHNDMASLENLLHELDEAEKKEKLPAIPRKFIVTEGIFHRTGEIAP 301
QNALQLSRSTVYY+ HNDM SLE LL+EL E EK EKLPAIPRKFIVTEGIFH +G++AP
Sbjct: 243 QNALQLSRSTVYYFNHNDMNSLECLLNELTEQEKLEKLPAIPRKFIVTEGIFHNSGDLAP 302
Query: 302 LPELVQLKRKYKYRLFIDETFSIGVLGATGRGLTEYYNINRATSIDITVGSLATAIGSSG 361
LPEL +LK KYK+RLF+DETFSIGVLGATGRGL+E++N++RAT+IDITVGS+ATA+GS+G
Sbjct: 303 LPELTKLKNKYKFRLFVDETFSIGVLGATGRGLSEHFNMDRATAIDITVGSMATALGSTG 362
Query: 362 GFVLGDNVMVRHQRIGSNAYCFSASLPPYAVRTASTVLQMMDEDNSSVTKLRYLSNKLHE 421
GFVLGD+VM HQRIGSNAYCFSA LP Y V + S VL++MD +N +V L+ LS LH+
Sbjct: 363 GFVLGDSVMCLHQRIGSNAYCFSACLPAYTVTSVSKVLKLMDSNNDAVQTLQKLSKSLHD 422
Query: 422 WFQTDTELLRYIEVTSHRDSSVLHFQLTDAQRQQKFGSSIESVFQESQYQQQHCISDHFV 481
F +D L Y+ VTS S+VLH QLT A R +KFG + E +F+ Q+ ++ F+
Sbjct: 423 SFASDDSLRSYVIVTSSPVSAVLHLQLTPAYRSRKFGYTCEQLFETMSALQKKSQTNKFI 482
Query: 482 ESWEKEEIFLQAIVDTVLIDGNILISRDTIVLKQETLPVTPNISICCNSSMEESQLLDAY 541
E +E+EE FLQ+IVD LI+ N+LI+R+TIVLKQETLP+ P++ ICCN++M +L +A
Sbjct: 483 EPYEEEEKFLQSIVDHALINYNVLITRNTIVLKQETLPIVPSLKICCNAAMSPEELKNAC 542
Query: 542 NVIRIAIIKHCSEA 555
++ +I+ C E+
Sbjct: 543 ESVKQSILACCQES 556
>SPBC18E5.02c [O] KOG1358 Serine palmitoyltransferase
Length = 509
Score = 289 bits (740), Expect = 7e-78
Identities = 176/514 (34%), Positives = 272/514 (52%), Gaps = 52/514 (10%)
Query: 33 ITFF----KLIPGAHYVIDYVEKSHQDDPYRTFVEVLLILYSIVYFLSKPKKKGAVDQPK 88
+TFF ++PG+ V Y++ S+Q+DP RTF+E LL++++ Y L KP+ + +
Sbjct: 19 VTFFGKALDVLPGSPIVKRYIKSSYQNDPLRTFIEFLLLVFAAYYVLRKPRTSPDNNYVE 78
Query: 89 LSEKEIDNLXXXXXXXXXXXXXXRNE-WRLAKIPVIEGSGADNVINITRDNGKEAYASAF 147
+EKEI+ L E L IPV+E + R
Sbjct: 79 FTEKEINELVDDWKPEPLVAELTDVEKLELKSIPVLESVHLHTKLIDGRP--------IT 130
Query: 148 NLCSFNFLQLSKHPRVVEIAKEIIKNYGVGSCGPAGFYGNEDVHYNLEYDLASFFGTENS 207
N SFNFL L+++ + E A ++ G+G+CGP GFYG +D H LE D+ASF G E +
Sbjct: 131 NFASFNFLDLAENKHITECAVATLRECGLGACGPPGFYGTQDKHLRLEKDIASFIGVERA 190
Query: 208 VLYGQDFCVSSSVIPAFTKRGDVIVADDKISVSSQNALQLSRSTVYYYKHNDMASLENLL 267
++Y Q F SSVIPAF+KRGD++V D+ + + Q +Q+SR+T+ Y+KHN+M LE +L
Sbjct: 191 IVYAQSFQTISSVIPAFSKRGDILVVDEACNFAIQKGIQISRTTIRYFKHNNMKDLERIL 250
Query: 268 HELDEAEKKEKLPAIPRKFIVTEGIFHRTGEIAPLPELVQLKRKYKYRLFIDETFSIGVL 327
EL++ K P + R+FI+TEGI G++ L ++V LK+KYKYRL +DET+S G
Sbjct: 251 QELEDDFVKHNRP-LTRRFIITEGISENYGDMVDLTKIVALKKKYKYRLILDETWSFGTC 309
Query: 328 GATGRGLTEYYNINRATSIDITVGSLATAIGSSGGFVLGDNVMVRHQRIGSNAYCFSASL 387
G TG+GLTE++ + T ++I +GSL T++ GGF G +MV HQR+ AY +SA+L
Sbjct: 310 GRTGKGLTEHFGV-PPTDVEIIIGSLTTSLAGGGGFCAGSELMVEHQRLSGMAYIYSAAL 368
Query: 388 PPYAVRTASTVLQMMDEDNSS-VTKLRYLSNKLHEWFQTDTELLRYIEVTSHRDSSVLHF 446
P A + ++ D S + LR S H + ++ E +S +S ++H
Sbjct: 369 PASLAVAAYEAISILSRDGGSMLNDLRSKSALFHAKLSRN----KFFETSSDIESPIIHL 424
Query: 447 QLTDAQRQQKFGSSIESVFQESQYQQQHCISDHFVESWEKEEIFLQAIVDTVLIDGNILI 506
+ D S +K+ L+ IV+ + +G LI
Sbjct: 425 RFKDKD-----------------------------ISHDKQVFLLEEIVELCIAEG-FLI 454
Query: 507 SRDTIVLKQETLPVTPNISICCNS--SMEESQLL 538
+R V E + V P++ IC ++ S EE + L
Sbjct: 455 ARAKRVESLERVKVQPSLRICISTGHSAEEIEKL 488
>CE08323 [O] KOG1358 Serine palmitoyltransferase
Length = 458
Score = 264 bits (674), Expect = 3e-70
Identities = 168/500 (33%), Positives = 255/500 (50%), Gaps = 53/500 (10%)
Query: 56 DPYRTFVEVLLI-LYSIVYFLSKPKKKGAVDQPKLSEKEIDNLXXXXXXXXXXXXXXRNE 114
D + ++E LL+ L + V ++ K++ KL+E++ D L ++
Sbjct: 6 DSWHFYIETLLVALLAYVVMRNRSKRQQEKLSKKLTERQKDELIADWTPEPLVPETPQDH 65
Query: 115 WRLAKIPVIEGSGADNVINITRDNGKEAYASAFNLCSFNFLQLSKHPRVVEIAKEIIKNY 174
PV+ AD + E Y N+ S NFL R+ + AK+ I Y
Sbjct: 66 ------PVLNPKYADGKMTKDVSIDGEKY---LNMASTNFLSFIGVKRIEDRAKQTIFKY 116
Query: 175 GVGSCGPAGFYGNEDVHYNLEYDLASFFGTENSVLYGQDFCVSSSVIPAFTKRGDVIVAD 234
GVGSCGP GFYG DVH +LE +LA F G E +VLY F SS IPA+ K+GDVI D
Sbjct: 117 GVGSCGPRGFYGTVDVHLDLEKELAKFMGCEEAVLYSYGFATVSSAIPAYAKKGDVIFVD 176
Query: 235 DKISVSSQNALQLSRSTVYYYKHNDMASLENLLHELDEAEKKE-KLPAIPRKFIVTEGIF 293
+ ++ + Q LQ SRS V Y+KHNDM LE LL E ++ +KK+ K R+FIV EG++
Sbjct: 177 EGVNFAIQKGLQASRSRVEYFKHNDMEHLERLLLEQEQRDKKDPKKAKSVRRFIVVEGLY 236
Query: 294 HRTGEIAPLPELVQLKRKYKYRLFIDETFSIGVLGATGRGLTEYYNINRATSIDITVGSL 353
++ PLP++++ K ++K R+FIDE++S GV+G TGRG+TE++N+ +D+ + SL
Sbjct: 237 VNYADLCPLPKIIEFKWRFKVRVFIDESWSFGVIGKTGRGVTEHFNV-PMEDVDMVMASL 295
Query: 354 ATAIGSSGGFVLGDNVMVRHQRIGSNAYCFSASLPPYAVRTASTVLQMMDEDNSSVTKLR 413
A+ S+GGF +G + +V HQR+ YCFSASLPP AS + ++DE+ S V K+
Sbjct: 296 ENALASTGGFCVGRSYVVGHQRLSGLGYCFSASLPPLLATAASEAISIIDEEPSRVQKV- 354
Query: 414 YLSNKLHEWFQTDTELLRYIEVTSHRDSSVLHFQLTDAQRQQKFGSSIESVFQESQYQQQ 473
TE+ A QK ++ S++ Q
Sbjct: 355 -------------TEM---------------------AINGQK---KLQDALSGSKFSLQ 377
Query: 474 HCISD---HFVESWEKEEIFLQAIVDTVLIDGNILISRDTIVLKQETLPVTPNISICCNS 530
C H + E EE L V+TV ++L++R + K E + P+I +
Sbjct: 378 GCPESPMKHIYYNGEDEEKQLDTFVETVFTKNHLLLTRARYLDKDELFKIRPSIRVMFQH 437
Query: 531 SMEESQLLDAYNVIRIAIIK 550
+ E ++ A + IR+ K
Sbjct: 438 DLTEEEIQRAVDAIRVVAHK 457
>Hs5454084 [O] KOG1358 Serine palmitoyltransferase
Length = 473
Score = 251 bits (642), Expect = 2e-66
Identities = 172/511 (33%), Positives = 253/511 (48%), Gaps = 65/511 (12%)
Query: 45 VIDYVEKSHQDDPYRTFVEVLLILYSIVYFLSKPKKKGAVDQPKLSEKEIDNLXXXXXXX 104
+++ V+ ++ Y +E +LIL+ I SK K ++ L+ KE + L
Sbjct: 10 LVEMVQALYEAPAYHLILEGILILWIIRLLFSKTYK--LQERSDLTVKEKEELI------ 61
Query: 105 XXXXXXXRNEWRLAKI--PVIEGSGADNVINI-------TRDNGKEAYASAFNLCSFNFL 155
EW+ + PV + A N + T NGKE N SFNFL
Sbjct: 62 --------EEWQPEPLVPPVPKDHPALNYNIVSGPPSHKTVVNGKEC----INFASFNFL 109
Query: 156 QLSKHPRVVEIAKEIIKNYGVGSCGPAGFYGNEDVHYNLEYDLASFFGTENSVLYGQDFC 215
L +PRV A +K YGVG+CGP GFYG DVH +LE LA F TE +++Y F
Sbjct: 110 GLLDNPRVKAAALASLKKYGVGTCGPRGFYGTFDVHLDLEDRLAKFMKTEEAIIYSYGFA 169
Query: 216 VSSSVIPAFTKRGDVIVADDKISVSSQNALQLSRSTVYYYKHNDMASLENLLHELD-EAE 274
+S IPA++KRGD++ D + Q LQ SRS + +KHNDMA LE LL E + E +
Sbjct: 170 TIASAIPAYSKRGDIVFVDRAACFAIQKGLQASRSDIKLFKHNDMADLERLLKEQEIEDQ 229
Query: 275 KKEKLPAIPRKFIVTEGIFHRTGEIAPLPELVQLKRKYKYRLFIDETFSIGVLGATGRGL 334
K + + R+FIV EG++ TG I PLPELV+LK KYK R+F++E+ S GVLG GRG+
Sbjct: 230 KNPRKARVTRRFIVVEGLYMNTGTICPLPELVKLKYKYKARIFLEESLSFGVLGEHGRGV 289
Query: 335 TEYYNINRATSIDITVGSLATAIGSSGGFVLGDNVMVRHQRIGSNAYCFSASLPPYAVRT 394
TE+Y IN ID+ ++ A+ S GGF G + ++ HQR+ YCFSASLPP
Sbjct: 290 TEHYGIN-IDDIDLISANMENALASIGGFCCGRSFVIDHQRLSGQGYCFSASLPPLLAAA 348
Query: 395 ASTVLQMMDEDNSSVTKLRYLSNKLHEWFQTDTELLRYIEVTSHRDSSVLHFQLTDAQRQ 454
A L +M+E+ L+ ++H+ Q + ++V S H QL ++
Sbjct: 349 AIEALNIMEENPGIFAVLKEKCGQIHKALQG----ISGLKVVGESLSPAFHLQLEES--- 401
Query: 455 QKFGSSIESVFQESQYQQQHCISDHFVESWEKEEIFLQAIVDTVLIDGNILISRDTIVLK 514
S E++ LQ IVD + + +I +++ + K
Sbjct: 402 --------------------------TGSREQDVRLLQEIVDQCM-NRSIALTQARYLEK 434
Query: 515 QETLPVTPNISICCNSSMEESQLLDAYNVIR 545
+E P+I + E +L A + I+
Sbjct: 435 EEKCLPPPSIRVVVTVEQTEEELERAASTIK 465
>7303358 [O] KOG1358 Serine palmitoyltransferase
Length = 468
Score = 245 bits (625), Expect = 1e-64
Identities = 142/400 (35%), Positives = 217/400 (53%), Gaps = 40/400 (10%)
Query: 148 NLCSFNFLQLSKHPRVVEIAKEIIKNYGVGSCGPAGFYGNEDVHYNLEYDLASFFGTENS 207
NL S N+L + ++E A + ++ YGVGSCGP GFYG DVH +LE +A F G E +
Sbjct: 98 NLGSHNYLGFLEDQEILEEACKSLRKYGVGSCGPRGFYGTMDVHLDLEDRIAKFMGLEEA 157
Query: 208 VLYGQDFCVSSSVIPAFTKRGDVIVADDKISVSSQNALQLSRSTVYYYKHNDMASLENLL 267
++Y F +S IPA+ KRGD+I D+ ++ + Q L SRST+ ++KHND+ LE LL
Sbjct: 158 IVYSYGFSTVASAIPAYAKRGDLIFVDEAVNFAIQKGLDASRSTIVFFKHNDVEDLERLL 217
Query: 268 HELDEAEKKE-KLPAIPRKFIVTEGIFHRTGEIAPLPELVQLKRKYKYRLFIDETFSIGV 326
E ++ ++K K A R+F+V EGI+ TGEI PLP+LV L++KYK RLFIDE+ S G
Sbjct: 218 IEQEKRDQKNPKKAAKTRRFLVAEGIYMNTGEICPLPDLVALRQKYKLRLFIDESISFGT 277
Query: 327 LGATGRGLTEYYNINRATSIDITVGSLATAIGSSGGFVLGDNVMVRHQRIGSNAYCFSAS 386
LG G G+TE++N++R +D+ + ++ + GGF +G + + HQR+ Y FSAS
Sbjct: 278 LGQGGHGVTEHFNVDR-DEVDLISAGMEGSMATVGGFCVGSHFIAEHQRLSGLGYIFSAS 336
Query: 387 LPPYAVRTASTVLQMMDEDNSSVTKLRYLSNKLHEWFQTDTELLRYIEVTSHRD--SSVL 444
LPP + A + L + + +L+ S LH+ F LR+ ++T D S V
Sbjct: 337 LPPMLTQAAISALDRFEREPQIFEQLQAKSKTLHQKF------LRFSKLTLRGDEVSPVK 390
Query: 445 HFQLTDAQRQQKFGSSIESVFQESQYQQQHCISDHFVESWEKEEIFLQAIVDTVLIDGNI 504
H L E+++KE L + D + G +
Sbjct: 391 HLYLAQP-----------------------------AENFDKELKLLTELADKCIARG-V 420
Query: 505 LISRDTIVLKQETLPVTPNISICCNSSMEESQLLDAYNVI 544
+ + + +E PV P+I I N +E S++ +A+ VI
Sbjct: 421 AVVQAAYLQNRERQPVRPSIRIAVNRLLESSEIDNAFEVI 460
>At4g36480 [O] KOG1358 Serine palmitoyltransferase
Length = 475
Score = 227 bits (579), Expect = 3e-59
Identities = 118/285 (41%), Positives = 175/285 (61%), Gaps = 12/285 (4%)
Query: 121 PVIEGSGADNVINITRDNGKEAYASAFNLCSFNFLQLSKHPRVVEIAKEIIKNYGVGSCG 180
PV+E + + T NGK+ N S N+L L H +++E ++ YGVGSCG
Sbjct: 94 PVLESAAGPH----TTVNGKDVV----NFASANYLGLIGHEKLLESCTSALEKYGVGSCG 145
Query: 181 PAGFYGNEDVHYNLEYDLASFFGTENSVLYGQDFCVSSSVIPAFTKRGDVIVADDKISVS 240
P GFYG DVH + E ++ F GT +S+LY S IP F K+GDVIVAD+ +
Sbjct: 146 PRGFYGTIDVHLDCETRISKFLGTPDSILYSYGLSTMFSTIPCFCKKGDVIVADEGVHWG 205
Query: 241 SQNALQLSRSTVYYYKHNDMASLENLLHELDEAEKKEKLPAIPRKFIVTEGIFHRTGEIA 300
QN LQLSRST+ Y+KHNDM SL L ++ K+ K R++IV E ++ +G+IA
Sbjct: 206 IQNGLQLSRSTIVYFKHNDMESLRITLEKIMTKYKRSK---NLRRYIVAEAVYQNSGQIA 262
Query: 301 PLPELVQLKRKYKYRLFIDETFSIGVLGATGRGLTEYYNINRATSIDITVGSLATAIGSS 360
PL E+V+LK KY++R+ +DE+ S GVLG +GRGL E++++ ID+ ++ A+ +
Sbjct: 263 PLDEIVKLKEKYRFRVILDESNSFGVLGRSGRGLAEHHSV-PIEKIDVVTAAMGHALATE 321
Query: 361 GGFVLGDNVMVRHQRIGSNAYCFSASLPPYAVRTASTVLQMMDED 405
GGF G+ ++ +QR+ S+ Y FSASLPPY A T + ++D++
Sbjct: 322 GGFCTGNARIIDYQRLSSSGYVFSASLPPYLASAAITAIDVIDQN 366
>Hs4758668 [O] KOG1357 Serine palmitoyltransferase
Length = 562
Score = 155 bits (393), Expect = 1e-37
Identities = 89/266 (33%), Positives = 148/266 (55%), Gaps = 3/266 (1%)
Query: 148 NLCSFNFLQLSKHP-RVVEIAKEIIKNYGVGSCGPAGFYGNEDVHYNLEYDLASFFGTEN 206
N+ S+N+L +++ E A ++++ YG G C GN D H LE +A F G E
Sbjct: 172 NMGSYNYLGFARNTGSCQEAAAKVLEEYGAGVCSTRQEIGNLDKHEELEELVARFLGVEA 231
Query: 207 SVLYGQDFCVSSSVIPAFTKRGDVIVADDKISVSSQNALQLSRSTVYYYKHNDMASLENL 266
++ YG F +S IPA +G +I++D+ S +LS +T+ +KHN+M SLE L
Sbjct: 232 AMAYGMGFATNSMNIPALVGKGCLILSDELNHASLVLGARLSGATIRIFKHNNMQSLEKL 291
Query: 267 LHELDEAEKKEKLPAIPRKFIVTEGIFHRTGEIAPLPELVQLKRKYKYRLFIDETFSIGV 326
L + + + I+ EGI+ G I LPE++ LK+KYK L++DE SIG
Sbjct: 292 LKDAIVYGQPRTRRPWKKILILVEGIYSMEGSIVRLPEVIALKKKYKAYLYLDEAHSIGA 351
Query: 327 LGATGRGLTEYYNINRATSIDITVGSLATAIGSSGGFVLGDNVMVRHQRIGSNAYCFSAS 386
LG TGRG+ EY+ ++ +D+ +G+ + G+SGG++ G ++ + R S++ ++ S
Sbjct: 352 LGPTGRGVVEYFGLD-PEDVDVMMGTFTKSFGASGGYIGGKKELIDYLRTHSHSAVYATS 410
Query: 387 LPPYAVRTASTVLQ-MMDEDNSSVTK 411
L P V T ++ +M +D +S+ K
Sbjct: 411 LSPPVVEQIITSMKCIMGQDGTSLGK 436
>7298232 [O] KOG1357 Serine palmitoyltransferase
Length = 597
Score = 147 bits (372), Expect = 3e-35
Identities = 82/277 (29%), Positives = 156/277 (55%), Gaps = 9/277 (3%)
Query: 148 NLCSFNFLQLSKHP-RVVEIAKEIIKNYGVGSCGPAGFYGNEDVHYNLEYDLASFFGTEN 206
NL S+N+L + + + ++E ++ G+ C G+ + LE A +FG E+
Sbjct: 217 NLGSYNYLGFAAATGQCADDSEESARSSGLAYCSSRCELGDNEQLQELEALTARYFGVED 276
Query: 207 SVLYGQDFCVSSSVIPAFTKRGDVIVADDKISVSSQNALQLSRSTVYYYKHNDMASLENL 266
++++G F ++ +P+ ++++D+K S L+LS +T +KHN+M LE +
Sbjct: 277 AIVFGMGFATNALNLPSLLGPNSLVISDEKNHASIILGLRLSGATTKVFKHNNMRDLERV 336
Query: 267 LHE-LDEAEKKEKLPAIPRKFIVTEGIFHRTGEIAPLPELVQLKRKYKYRLFIDETFSIG 325
L + + K+ + I+ EGIF G I LPE++ LK+KYK L++DE S+G
Sbjct: 337 LRQGVCYGNPKKGGQPWDKVMILVEGIFSMEGSIVRLPEVIALKKKYKAYLYLDEAHSVG 396
Query: 326 VLGATGRGLTEYYNINRATSIDITVGSLATAIGSSGGFVLGDNVMVRHQRIGSNAYCFSA 385
+G+ GRG+T+Y+N++ +DI +G+ + GS+GG++ G ++ R S+A+C++A
Sbjct: 397 AMGSRGRGVTDYFNVD-PKEVDILMGTFTKSFGSAGGYLAGSKKLIDFLRTNSHAHCYAA 455
Query: 386 SL-PPYAVRTASTVLQMMDEDNSSVTKLRYLSNKLHE 421
S+ PP A + +++ +M ED + + + K+H+
Sbjct: 456 SISPPIAQQILTSMKTIMGEDGTDIGR-----KKIHQ 487
>7294669 [E] KOG1359 Glycine C-acetyltransferase/2-amino-3-ketobutyrate-CoA
ligase
Length = 404
Score = 147 bits (370), Expect = 5e-35
Identities = 83/256 (32%), Positives = 131/256 (50%), Gaps = 13/256 (5%)
Query: 148 NLCSFNFLQLSKHPRVVEIAKEIIKNYGVGSCGPAGFYGNEDVHYNLEYDLASFFGTENS 207
N C+ N+L L+ +P +VE ++++++ YG G G +D+H LE +A F G E++
Sbjct: 55 NFCANNYLGLANNPEIVEHSQKLLEQYGAGLSSVRFICGTQDIHKQLEKKIAQFHGREDT 114
Query: 208 VLYGQDFCVSSSVIPAFTKRGDVIVADDKISVSSQNALQLSRSTVYYYKHNDMASLENLL 267
+LY F ++ + A D + +D+ S + ++L ++ Y+H D+ LE L
Sbjct: 115 ILYASCFDANAGIFEAILTPEDAVFSDELNHASIIDGIRLCKAKKQRYRHRDLGDLEEQL 174
Query: 268 HELDEAEKKEKLPAIPRKFIVTEGIFHRTGEIAPLPELVQLKRKYKYRLFIDETFSIGVL 327
D K I T+G+F G IAPL +V+L RKY +F+DE + G
Sbjct: 175 KASDAR----------LKLIATDGVFSMDGNIAPLARIVELARKYNALVFVDECHATGFF 224
Query: 328 GATGRGLTEYYNINRATSIDITVGSLATAI-GSSGGFVLGDNVMVRHQRIGSNAYCFSAS 386
GATGRG EY N+ +DI +L A+ G+SGG+ G ++ R S Y FS +
Sbjct: 225 GATGRGTEEYDNV--MGEVDIINSTLGKALGGASGGYTTGPAELISFLRQKSRPYLFSNT 282
Query: 387 LPPYAVRTASTVLQMM 402
LPP V V+ M+
Sbjct: 283 LPPAVVAVGLKVMDML 298
>ECU02g0860 [O] KOG1358 Serine palmitoyltransferase
Length = 422
Score = 142 bits (358), Expect = 1e-33
Identities = 85/256 (33%), Positives = 137/256 (53%), Gaps = 27/256 (10%)
Query: 146 AFNLCSFNFLQLSKHPRVVEIAKEIIKNYGVGSCGPAGFYGNEDVHYNLEYDLASFFGTE 205
A +L +F+ LS + I ++I+ YGVG+CGP GFYG D+H +LE + G E
Sbjct: 80 ATDLANFDVFGLSTENKKEVI--DVIRKYGVGTCGPRGFYGTLDLHLDLEETITKELGAE 137
Query: 206 NSVLYGQDFCVSSSVIPAFTKRGDVIVADDKISVSSQNALQLSRSTVYYYKHNDMASLEN 265
S++Y F +S+I F K+ D++ + + + ++LSRS K + S+ +
Sbjct: 138 ASIVYPNSFTAINSIITCFCKQQDIVFYHEDSNEAILRGIELSRS-----KTIEFGSISD 192
Query: 266 LLHELDEAEKKEKLPAIPRKFIVTEGIFHRTGEIAPLPELVQLKRKYKYRLFIDETFSI- 324
L +L+ R F+V EG+F TG I + +++L+ KYK+R+ +DE++SI
Sbjct: 193 LEIKLEYFGNPN-----VRNFVVVEGLFRNTGRIIEIRRILELRNKYKFRIILDESYSIP 247
Query: 325 -----GVLGATGRGLTEYYNINRATSIDITVGSLATAIGSSGGFVLGDNVMVRHQRIGSN 379
GV G G G+ E IDI +GSL+ + SSG F G + +Q++ +
Sbjct: 248 LLDKRGVCGMEGIGIKE---------IDIVIGSLSGGLCSSGAFATGTHSTADYQKLSGS 298
Query: 380 AYCFSASLPPYAVRTA 395
+YCFSAS+P V+ A
Sbjct: 299 SYCFSASIPGAMVKAA 314
>YDR062w [O] KOG1357 Serine palmitoyltransferase
Length = 561
Score = 137 bits (346), Expect = 3e-32
Identities = 77/259 (29%), Positives = 139/259 (52%), Gaps = 3/259 (1%)
Query: 148 NLCSFNFLQLSKHP-RVVEIAKEIIKNYGVGSCGPAGFYGNEDVHYNLEYDLASFFGTEN 206
NL S+N+L ++ + + A E + Y + S GP G D+H E +A F G E+
Sbjct: 159 NLSSYNYLGFAQSKGQCTDAALESVDKYSIQSGGPRAQIGTTDLHIKAEKLVARFIGKED 218
Query: 207 SVLYGQDFCVSSSVIPAFTKRGDVIVADDKISVSSQNALQLSRSTVYYYKHNDMASLENL 266
++++ + ++++ AF + ++++D+ S + ++LS + V +KH DM LE L
Sbjct: 219 ALVFSMGYGTNANLFNAFLDKKCLVISDELNHTSIRTGVRLSGAAVRTFKHGDMVGLEKL 278
Query: 267 LHELDEAEKKEKLPAIPRKFIVTEGIFHRTGEIAPLPELVQLKRKYKYRLFIDETFSIGV 326
+ E + + + I EG+F G + LP+LV+LK+KYK LFIDE SIG
Sbjct: 279 IREQIVLGQPKTNRPWKKILICAEGLFSMEGTLCNLPKLVELKKKYKCYLFIDEAHSIGA 338
Query: 327 LGATGRGLTEYYNINRATSIDITVGSLATAIGSSGGFVLGDNVMVRHQRIGSNAYCFSAS 386
+G TGRG+ E + ++ +DI +G+ + G++GG++ D ++ R+ +S S
Sbjct: 339 MGPTGRGVCEIFGVD-PKDVDILMGTFTKSFGAAGGYIAADQWIIDRLRLDLTTVSYSES 397
Query: 387 LP-PYAVRTASTVLQMMDE 404
+P P +T S++ + E
Sbjct: 398 MPAPVLAQTISSLQTISGE 416
>At3g48780 [O] KOG1357 Serine palmitoyltransferase
Length = 489
Score = 137 bits (345), Expect = 4e-32
Identities = 96/343 (27%), Positives = 171/343 (48%), Gaps = 26/343 (7%)
Query: 118 AKIPVIEGSGADNVINITRDNGKEAYASAFNLCSFNFLQLSKH-----PRVVEIAKEIIK 172
A I V+E DN + R + NL S+N+L PRV+E +K
Sbjct: 77 AWIDVVERVSDDNNKTLKRTTKT---SRCLNLGSYNYLGFGSFDEYCTPRVIES----LK 129
Query: 173 NYGVGSCGPAGFYGNEDVHYNLEYDLASFFGTENSVLYGQDFCVSSSVIPAFTKRGDVIV 232
+ +C G VH LE +A + G +V++G + +S++IP +G +I+
Sbjct: 130 KFSASTCSSRVDAGTTSVHAELEDCVAKYVGQPAAVIFGMGYATNSAIIPVLIGKGGLII 189
Query: 233 ADDKISVSSQNALQLSRSTVYYYKHNDMASLENLLHE-LDEAEKKEKLPAIPRKFIVTEG 291
+D S N + S +T+ ++HN LE +L E + E + + P + +V EG
Sbjct: 190 SDSLNHTSIVNGARGSGATIRVFQHNTPGHLEKVLKEQIAEGQPRTHRPW-KKIIVVVEG 248
Query: 292 IFHRTGEIAPLPELVQLKRKYKYRLFIDETFSIGVLGATGRGLTEYYNINRATSIDITVG 351
I+ GEI LPE+V + +KYK +++DE SIG +G TGRG+ E ++ + +DI +G
Sbjct: 249 IYSMEGEICHLPEIVSICKKYKAYVYLDEAHSIGAIGKTGRGVCELLGVD-TSDVDIMMG 307
Query: 352 SLATAIGSSGGFVLGDNVMVRHQRIGSNAYCFSASL-PPYAVRTASTVLQMMDEDNSS-- 408
+ + GS GG++ G ++++ + A+ ++ S+ P A + S + ++ ED S+
Sbjct: 308 TFTKSFGSCGGYIAGSKDLIQYLKHQCPAHLYATSISTPSATQIISAIKVILGEDGSNRG 367
Query: 409 ---VTKLRYLSNKLHEWFQTDTELLRYIEVTSHRDSSVLHFQL 448
+ ++R SN +F+ + + + + EV DS V+ L
Sbjct: 368 AQKLARIRENSN----FFRAELQKMGF-EVLGDNDSPVMPIML 405
>Hs7657118 [E] KOG1359 Glycine C-acetyltransferase/2-amino-3-ketobutyrate-CoA
ligase
Length = 419
Score = 137 bits (344), Expect = 6e-32
Identities = 84/266 (31%), Positives = 136/266 (50%), Gaps = 12/266 (4%)
Query: 148 NLCSFNFLQLSKHPRVVEIAKEIIKNYGVGSCGPAGFYGNEDVHYNLEYDLASFFGTENS 207
N C+ N+L LS HP V++ + ++ +G G G + +H NLE +A F E++
Sbjct: 69 NFCANNYLGLSSHPEVIQAGLQALEEFGAGLSSVRFICGTQSIHKNLEAKIARFHQREDA 128
Query: 208 VLYGQDFCVSSSVIPAFTKRGDVIVADDKISVSSQNALQLSRSTVYYYKHNDMASLENLL 267
+LY + ++ + A D +++D+ S + ++L ++ Y Y+H DMA LE
Sbjct: 129 ILYPSCYDANAGLFEALLTPEDAVLSDELNHASIIDGIRLCKAHKYRYRHLDMADLE--- 185
Query: 268 HELDEAEKKEKLPAIPRKFIVTEGIFHRTGEIAPLPELVQLKRKYKYRLFIDETFSIGVL 327
+L EA+K + + T+G F G+IAPL E+ L +Y +F+DE + G L
Sbjct: 186 AKLQEAQKHR------LRLVATDGAFSMDGDIAPLQEICCLASRYGALVFMDECHATGFL 239
Query: 328 GATGRGLTEYYNI-NRATSIDITVGSLATAIGSSGGFVLGDNVMVRHQRIGSNAYCFSAS 386
G TGRG E + ++ T I+ T+G G+SGG+ G +V R + Y FS S
Sbjct: 240 GPTGRGTDELLGVMDQVTIINSTLGKALG--GASGGYTTGPGPLVSLLRQRARPYLFSNS 297
Query: 387 LPPYAVRTASTVLQMMDEDNSSVTKL 412
LPP V AS L ++ N+ V +
Sbjct: 298 LPPAVVGCASKALDLLMGSNTIVQSM 323
>At5g23670 [O] KOG1357 Serine palmitoyltransferase
Length = 489
Score = 137 bits (344), Expect = 6e-32
Identities = 94/337 (27%), Positives = 169/337 (49%), Gaps = 28/337 (8%)
Query: 129 DNVINITRDNGKEAYASA-----FNLCSFNFLQLSKH-----PRVVEIAKEIIKNYGVGS 178
D V + DN K + NL S+N+L PRV+E +K + +
Sbjct: 80 DVVERYSNDNNKTLKRTTKTSRCLNLGSYNYLGFGSFDEYCTPRVIES----LKKFSAST 135
Query: 179 CGPAGFYGNEDVHYNLEYDLASFFGTENSVLYGQDFCVSSSVIPAFTKRGDVIVADDKIS 238
C G VH LE + F G +V++G + +S++IP +G +I++D
Sbjct: 136 CSSRVDAGTTSVHAELEECVTRFVGKPAAVVFGMGYATNSAIIPVLIGKGGLIISDSLNH 195
Query: 239 VSSQNALQLSRSTVYYYKHNDMASLENLLHE-LDEAEKKEKLPAIPRKFIVTEGIFHRTG 297
S N + S +T+ ++HN + LE +L E + E + + P + +V EGI+ G
Sbjct: 196 SSIVNGARGSGATIRVFQHNTPSHLERVLREQIAEGQPRTHRPW-KKIIVVVEGIYSMEG 254
Query: 298 EIAPLPELVQLKRKYKYRLFIDETFSIGVLGATGRGLTEYYNINRATSIDITVGSLATAI 357
EI LPE+V + +KYK +++DE SIG +G TG+G+ E ++ A +D+ +G+ +
Sbjct: 255 EICHLPEVVAICKKYKAYVYLDEAHSIGAIGKTGKGICELLGVDTA-DVDVMMGTFTKSF 313
Query: 358 GSSGGFVLGDNVMVRHQRIGSNAYCFSASLP-PYAVRTASTVLQMMDEDNSS-----VTK 411
GS GG++ G ++++ + A+ ++ S+P P A + S + ++ ED S+ + +
Sbjct: 314 GSCGGYIAGSKELIQYLKHQCPAHLYATSIPTPSAQQIISAIKVILGEDGSNRGAQKLAR 373
Query: 412 LRYLSNKLHEWFQTDTELLRYIEVTSHRDSSVLHFQL 448
+R SN +F+ + + + + EV DS V+ L
Sbjct: 374 IRENSN----FFRAELQKMGF-EVLGDNDSPVMPIML 405
>CE13990 [O] KOG1357 Serine palmitoyltransferase
Length = 527
Score = 130 bits (326), Expect = 7e-30
Identities = 78/268 (29%), Positives = 130/268 (48%), Gaps = 3/268 (1%)
Query: 144 ASAFNLCSFNFLQLSKHPRV-VEIAKEIIKNYGVGSCGPAGFYGNEDVHYNLEYDLASFF 202
+ NL S+N+L S V E A I YG+ G GN H ++E +A +
Sbjct: 149 SEVINLGSYNYLGFSHRSGVCAEAAAAHIDKYGINCGGSRQEIGNHVAHKSVESTIAQYL 208
Query: 203 GTENSVLYGQDFCVSSSVIPAFTKRGDVIVADDKISVSSQNALQLSRSTVYYYKHNDMAS 262
E+++++ F +S IP+ +G +I++D S +LS + ++HND +
Sbjct: 209 NVEDAIVFPMGFATNSMNIPSLVDKGSLILSDRLNHASLVTGCRLSGAHTVVFRHNDASD 268
Query: 263 LENLLHELDEAEKKEKLPAIPRKFIVTEGIFHRTGEIAPLPELVQLKRKYKYRLFIDETF 322
E L + + + I+ EGI+ G I LP + +K+KY LF+DE
Sbjct: 269 CERKLRDALCGVSPKTGEKYNKVLIIIEGIYSMEGTIVNLPAFIAVKKKYNCYLFLDEAH 328
Query: 323 SIGVLGATGRGLTEYYNINRATSIDITVGSLATAIGSSGGFVLGDNVMVRHQRIGSNAYC 382
SIG +G +GRG+ EY+ N IDI +G+L + S+GG++ G ++ H R S C
Sbjct: 329 SIGAVGPSGRGVAEYWGCN-PRDIDIMMGTLTKSFASAGGYMGGSKKVIDHIRRYSAGTC 387
Query: 383 FSASL-PPYAVRTASTVLQMMDEDNSSV 409
+ ++ PP + VL M +D + +
Sbjct: 388 YGVTMSPPLIAQVERAVLIMSGKDGTDI 415
>ECU05g0730 [O] KOG1357 Serine palmitoyltransferase
Length = 475
Score = 127 bits (318), Expect = 6e-29
Identities = 76/245 (31%), Positives = 130/245 (53%), Gaps = 6/245 (2%)
Query: 148 NLCSFNFLQLS--KHPRVVEIAKEIIKNYGVGSCGPAGFYGNEDVHYNLEYDLASFFGTE 205
N S+N+L S K P V ++ K + + Y + PA G D+ LE ++ASF E
Sbjct: 109 NFGSYNYLGFSSNKGPVVEKVVKAVYR-YPLVLAAPAREVGCYDIARELEEEMASFLHQE 167
Query: 206 NSVLYGQDFCVSSSVIPAFTKRGDVIVADDKISVSSQNALQLSRSTVYYYKHNDMASLEN 265
+ +++ + +SS IP + +I++D+ S ++SR + ++HN+M LE
Sbjct: 168 DCMVFSMGYGTNSSNIPVICEEETLILSDELNHASLITGAKISRGVIRVFEHNNMEDLER 227
Query: 266 -LLHELDEAEKKEKLPAIPRKFIVTEGIFHRTGEIAPLPELVQLKRKYKYRLFIDETFSI 324
L+ + + + A + ++ EGI+ G + L LV+LKRKYK+ +F+DE SI
Sbjct: 228 KLVFNISQGQPLTHR-AWKKIIVIVEGIYSMEGTVVKLRRLVELKRKYKFYIFVDEAHSI 286
Query: 325 GVLGATGRGLTEYYNINRATSIDITVGSLATAIGSSGGFVLGDNVMVRHQRIGSNAYCFS 384
G LGATGRG+ E+ ++ T +DI +G+ + G GG++ G ++ R S+ +
Sbjct: 287 GALGATGRGVCEHTGVD-FTEVDILMGTFTKSFGGMGGYIAGSRKLITWLRFYSDMSLYG 345
Query: 385 ASLPP 389
LPP
Sbjct: 346 DQLPP 350
>CE27380 [O] KOG1357 Serine palmitoyltransferase
Length = 586
Score = 120 bits (301), Expect = 5e-27
Identities = 81/308 (26%), Positives = 141/308 (45%), Gaps = 12/308 (3%)
Query: 123 IEGSGADNVINITRDNGKEAY------ASAFNLCSFNFLQLSKHPR-VVEIAKEIIKNYG 175
+ G+ D V ++ D G Y + N+ S+N+L ++ E + I G
Sbjct: 175 VPGATVDLVDRVSHD-GNWTYEYPGTRTNVINVGSYNYLGFAQSAGPCAEQSASSIDREG 233
Query: 176 VGSCGPAGFYGNEDVHYNLEYDLASFFGTENSVLYGQDFCVSSSVIPAFTKRGDVIVADD 235
+ C G LE +A F G E+++ + F +S P + +I++D
Sbjct: 234 LSCCTTVHERGRSVSQAKLEKLVAEFLGVEDAICFSMGFATNSMNAPCLVDKHSLIISDK 293
Query: 236 KISVSSQNALQLSRSTVYYYKHNDMASLENLLHELDEAEKKEKLPAIPRKFIVTEGIFHR 295
S +LS ++ ++HNDM SLE +L + + + I+ EGI+
Sbjct: 294 YNHASLILGCRLSGASTKVFEHNDMESLERILRDAIAYGNPKTHRPYKKILIIVEGIYSM 353
Query: 296 TGEIAPLPELVQLKRKYKYRLFIDETFSIGVLGATGRGLTEYYNINRATSIDITVGSLAT 355
G I LP ++ LK+KY+ L++DE SIG +G TG+G+ EY+ + +DI +G+
Sbjct: 354 EGSICNLPGIIALKKKYQAYLYLDEAHSIGAMGKTGKGVVEYWGCD-PKDVDILMGTFTK 412
Query: 356 AIGSSGGFVLGDNVMVRHQRIGS-NAYCFSASLPPYA--VRTASTVLQMMDEDNSSVTKL 412
+ G++GG++ G V H R S Y S PP A + T+ +++ D ++
Sbjct: 413 SFGAAGGYIAGSKRTVDHLRAASPTGYYSSPMSPPIAQQIYTSMSIIMGKDGTKDGAQRI 472
Query: 413 RYLSNKLH 420
L+ H
Sbjct: 473 ERLARNSH 480
>CE07246 [O] KOG1357 Serine palmitoyltransferase
Length = 558
Score = 120 bits (301), Expect = 5e-27
Identities = 81/308 (26%), Positives = 141/308 (45%), Gaps = 12/308 (3%)
Query: 123 IEGSGADNVINITRDNGKEAY------ASAFNLCSFNFLQLSKHPR-VVEIAKEIIKNYG 175
+ G+ D V ++ D G Y + N+ S+N+L ++ E + I G
Sbjct: 147 VPGATVDLVDRVSHD-GNWTYEYPGTRTNVINVGSYNYLGFAQSAGPCAEQSASSIDREG 205
Query: 176 VGSCGPAGFYGNEDVHYNLEYDLASFFGTENSVLYGQDFCVSSSVIPAFTKRGDVIVADD 235
+ C G LE +A F G E+++ + F +S P + +I++D
Sbjct: 206 LSCCTTVHERGRSVSQAKLEKLVAEFLGVEDAICFSMGFATNSMNAPCLVDKHSLIISDK 265
Query: 236 KISVSSQNALQLSRSTVYYYKHNDMASLENLLHELDEAEKKEKLPAIPRKFIVTEGIFHR 295
S +LS ++ ++HNDM SLE +L + + + I+ EGI+
Sbjct: 266 YNHASLILGCRLSGASTKVFEHNDMESLERILRDAIAYGNPKTHRPYKKILIIVEGIYSM 325
Query: 296 TGEIAPLPELVQLKRKYKYRLFIDETFSIGVLGATGRGLTEYYNINRATSIDITVGSLAT 355
G I LP ++ LK+KY+ L++DE SIG +G TG+G+ EY+ + +DI +G+
Sbjct: 326 EGSICNLPGIIALKKKYQAYLYLDEAHSIGAMGKTGKGVVEYWGCD-PKDVDILMGTFTK 384
Query: 356 AIGSSGGFVLGDNVMVRHQRIGS-NAYCFSASLPPYA--VRTASTVLQMMDEDNSSVTKL 412
+ G++GG++ G V H R S Y S PP A + T+ +++ D ++
Sbjct: 385 SFGAAGGYIAGSKRTVDHLRAASPTGYYSSPMSPPIAQQIYTSMSIIMGKDGTKDGAQRI 444
Query: 413 RYLSNKLH 420
L+ H
Sbjct: 445 ERLARNSH 452
>Hs4502025 [H] KOG1360 5-aminolevulinate synthase
Length = 640
Score = 114 bits (284), Expect = 5e-25
Identities = 71/270 (26%), Positives = 127/270 (46%), Gaps = 13/270 (4%)
Query: 150 CSFNFLQLSKHPRVVEIAKEIIKNYGVGSCGPAGFYGNEDVHYNLEYDLASFFGTENSVL 209
CS ++L +S+HPRV + +K +G G+ G G H +LE +LA G + ++L
Sbjct: 249 CSNDYLGMSRHPRVCGAVMDTLKQHGAGAGGTRNISGTSKFHVDLERELADLHGKDAALL 308
Query: 210 YGQDFCVSSSVIPAFTKR--GDVIVADDKISVSSQNALQLSRSTVYYYKHNDMASLENLL 267
+ F + S + K G I +D S ++ SR Y ++HND++ L LL
Sbjct: 309 FSSCFVANDSTLFTLAKMMPGCEIYSDSGNHASMIQGIRNSRVPKYIFRHNDVSHLRELL 368
Query: 268 HELDEAEKKEKLPAIPRKFIVTEGIFHRTGEIAPLPELVQLKRKYKYRLFIDETFSIGVL 327
D P++P K + E + G + PL EL + ++ F+DE ++G+
Sbjct: 369 QRSD--------PSVP-KIVAFETVHSMDGAVCPLEELCDVAHEFGAITFVDEVHAVGLY 419
Query: 328 GATGRGLTEYYNINRATSIDITVGSLATAIGSSGGFVLGDNVMVRHQRIGSNAYCFSASL 387
GA G G+ + + +DI G+L A G GG++ + ++ R + + F+ SL
Sbjct: 420 GARGGGIGDRDGV--MPKMDIISGTLGKAFGCVGGYIASTSSLIDTVRSYAAGFIFTTSL 477
Query: 388 PPYAVRTASTVLQMMDEDNSSVTKLRYLSN 417
PP + A ++++ V + ++ N
Sbjct: 478 PPMLLAGALESVRILKSAEGRVLRRQHQRN 507
>Hs4557299 [H] KOG1360 5-aminolevulinate synthase
Length = 587
Score = 110 bits (276), Expect = 4e-24
Identities = 72/273 (26%), Positives = 127/273 (46%), Gaps = 13/273 (4%)
Query: 150 CSFNFLQLSKHPRVVEIAKEIIKNYGVGSCGPAGFYGNEDVHYNLEYDLASFFGTENSVL 209
CS ++L +S+HP+V++ +E ++ +G G+ G G H LE +LA ++++L
Sbjct: 195 CSNDYLGMSRHPQVLQATQETLQRHGAGAGGTRNISGTSKFHVELEQELAELHQKDSALL 254
Query: 210 YGQDFCVSSSVIPAFTK--RGDVIVADDKISVSSQNALQLSRSTVYYYKHNDMASLENLL 267
+ F + S + K G I +D S ++ S + + ++HND L+ LL
Sbjct: 255 FSSCFVANDSTLFTLAKILPGCEIYSDAGNHASMIQGIRNSGAAKFVFRHNDPDHLKKLL 314
Query: 268 HELDEAEKKEKLPAIPRKFIVTEGIFHRTGEIAPLPELVQLKRKYKYRLFIDETFSIGVL 327
+ + P IP K + E + G I PL EL + +Y F+DE ++G+
Sbjct: 315 EKSN--------PKIP-KIVAFETVHSMDGAICPLEELCDVSHQYGALTFVDEVHAVGLY 365
Query: 328 GATGRGLTEYYNINRATSIDITVGSLATAIGSSGGFVLGDNVMVRHQRIGSNAYCFSASL 387
G+ G G+ E I IDI G+L A G GG++ +V R + + F+ SL
Sbjct: 366 GSRGAGIGERDGIMH--KIDIISGTLGKAFGCVGGYIASTRDLVDMVRSYAAGFIFTTSL 423
Query: 388 PPYAVRTASTVLQMMDEDNSSVTKLRYLSNKLH 420
PP + A ++++ + + + N H
Sbjct: 424 PPMVLSGALESVRLLKGEEGQALRRAHQRNVKH 456
>At3g48790 [O] KOG1357 Serine palmitoyltransferase
Length = 350
Score = 108 bits (269), Expect = 3e-23
Identities = 65/229 (28%), Positives = 121/229 (52%), Gaps = 9/229 (3%)
Query: 186 GNEDVHYNLEYDLASFFGTENSVLYGQDFCVSSSVIPAFTKRGDVIVADDKISVSSQNAL 245
G VH LE +A F G +V++G + +S++I +G +I++D S N
Sbjct: 7 GTTAVHGELEECVAKFVGKPAAVVFGMGYLTNSAIISVLIGKGGLIISDSLNHTSIINGA 66
Query: 246 QLSRSTVYYYKHNDMASLENLLHELDEAEKKEKLPAIPRKFIVTEGIFHRTGEIAPLPEL 305
+ S +T+ ++HN + E+++ + K + +V EGI+ GEI LPE+
Sbjct: 67 RGSGATIRVFQHNILK--EHIIEGQPRTHRPWK-----KIIVVVEGIYSMEGEICDLPEI 119
Query: 306 VQLKRKYKYRLFIDETFSIGVLGATGRGLTEYYNINRATSIDITVGSLATAIGSSGGFVL 365
V + +YK +++DE SIG +G TGRG+ E ++ T +DI +G+ ++GS GG++
Sbjct: 120 VSVCSEYKAYVYLDEAHSIGAIGKTGRGVCELLGVD-TTEVDIMMGTFTKSLGSCGGYIA 178
Query: 366 GDNVMVRHQRIGSNAYCFSASL-PPYAVRTASTVLQMMDEDNSSVTKLR 413
G +V++ + A+ ++ S+ P A + S + + D S+ +L+
Sbjct: 179 GSKDLVQYLKQHYPAHLYATSISTPAAQQVISAIKVIFGVDGSNRGELK 227
>SPAC2F3.09 [H] KOG1360 5-aminolevulinate synthase
Length = 558
Score = 107 bits (268), Expect = 4e-23
Identities = 66/259 (25%), Positives = 121/259 (46%), Gaps = 12/259 (4%)
Query: 150 CSFNFLQLSKHPRVVEIAKEIIKNYGVGSCGPAGFYGNEDVHYNLEYDLASFFGTENSVL 209
CS ++L + H ++ E + I+ YG G+ G G+ LE LA +++
Sbjct: 180 CSNDYLNMGGHKKIREAMHQCIETYGGGAGGTRNIAGHNQHAVRLEKSLADLHQKPAALV 239
Query: 210 YGQDFCVSSSVIPAFTKR--GDVIVADDKISVSSQNALQLSRSTVYYYKHNDMASLENLL 267
+G + + + + ++ + ++D+ S N ++ SR +KHND+ LE
Sbjct: 240 FGSCYVANDATLSTLGRKLPNCIFLSDEMNHASMINGIRNSRCEKIIFKHNDLVDLE--- 296
Query: 268 HELDEAEKKEKLPAIPRKFIVTEGIFHRTGEIAPLPELVQLKRKYKYRLFIDETFSIGVL 327
K LP K I E ++ +G +AP+ E+ L +KY F+DE ++G+
Sbjct: 297 ------AKLASLPLNRPKIIAFESVYSMSGNVAPISEICDLAKKYGAITFLDEVHAVGMY 350
Query: 328 GATGRGLTEYYNINRATSIDITVGSLATAIGSSGGFVLGDNVMVRHQRIGSNAYCFSASL 387
G G G+ E + +DI G+LA + G GG++ + +V R + + F+ SL
Sbjct: 351 GPRGAGVAE-ETPGLLSRVDIITGTLAKSYGCVGGYIAASSTLVDMIRSLAPGFIFTTSL 409
Query: 388 PPYAVRTASTVLQMMDEDN 406
PP+ + A T ++ + N
Sbjct: 410 PPHVMVGALTAVEHLKVSN 428
>YDR232w [H] KOG1360 5-aminolevulinate synthase
Length = 548
Score = 104 bits (260), Expect = 3e-22
Identities = 73/298 (24%), Positives = 135/298 (44%), Gaps = 35/298 (11%)
Query: 150 CSFNFLQLSKHPRVVEIAKEIIKNYGVGSCGPAGFYGNEDVHYNLEYDLASFFGTENSVL 209
CS ++L LSKHP V++ + I YG G+ G G+ NLE +LA+ E +++
Sbjct: 119 CSNDYLALSKHPEVLDAMHKTIDKYGCGAGGTRNIAGHNIPTLNLEAELATLHKKEGALV 178
Query: 210 YGQDFCVSSSVIPAF-TKRGDVIVADDKISVSSQ-NALQLSRSTVYYYKHNDMASLENLL 267
+ + + +V+ K D+++ D+++ +S ++ + + +KHND+ LE LL
Sbjct: 179 FSSCYVANDAVLSLLGQKMKDLVIFSDELNHASMIVGIKHANVKKHIFKHNDLNELEQLL 238
Query: 268 HELDEAEKKEKLPAIPRKFIVTEGIFHRTGEIAPLPELVQLKRKYKYRLFIDETFSIGVL 327
+ P K I E ++ G +A + ++ L KY F+DE ++G+
Sbjct: 239 ---------QSYPKSVPKLIAFESVYSMAGSVADIEKICDLADKYGALTFLDEVHAVGLY 289
Query: 328 GATGRGLTEY--YNINRATSI------------------DITVGSLATAIGSSGGFVLGD 367
G G G+ E+ + +RA+ I D+ G+L + GS GG+V
Sbjct: 290 GPHGAGVAEHCDFESHRASGIATPKTNDKGGAKTVMDRVDMITGTLGKSFGSVGGYVAAS 349
Query: 368 NVMVRHQRIGSNAYCFSASLPPYAVRTASTVLQM----MDEDNSSVTKLRYLSNKLHE 421
++ R + + F+ +LPP + A+ ++ +D S Y+ HE
Sbjct: 350 RKLIDWFRSFAPGFIFTTTLPPSVMAGATAAIRYQRCHIDLRTSQQKHTMYVKKAFHE 407
>Hs18597111 [E] KOG1359 Glycine C-acetyltransferase/2-amino-3-ketobutyrate-CoA
ligase
Length = 348
Score = 99.8 bits (247), Expect = 1e-20
Identities = 73/245 (29%), Positives = 119/245 (47%), Gaps = 27/245 (11%)
Query: 186 GNEDVHYNLEYDLASFFGTENSVLYGQDFCVSSSVIPAFTKRGDVIVADDKISVSSQNAL 245
G + +H NLE +A F E+++LY ++ + + D +++D+ S + +
Sbjct: 78 GTQSIHKNLEAKIARFHQREDAILYPSCCDANAGLFEVLLRPEDAVLSDELNCASIIHGI 137
Query: 246 QLSRSTVYYYKHNDMASLENLLHELDEAEKKEKLPAIPRKFIV-TEGIFHRTGEIAPLPE 304
L ++ Y+Y H D+A LE +L EA+K R F+V T+G F G+I PL +
Sbjct: 138 CLCKAHKYHYCHLDVAYLET---KLQEAQKH-------RLFLVATDGAFSMDGDIVPLQK 187
Query: 305 LVQLKRKYKYRLFIDETFSIGVLGATGRGLTEYYNI-NRATSIDITVGSLATAIGSSGGF 363
+ +L +Y +F+DE + G LG TG+G E + + T I+ T+G G+SGG+
Sbjct: 188 ICRLASRYGALVFVDECHATGFLGLTGQGTDELLGVMGQVTIINSTLGKALG--GASGGY 245
Query: 364 VLGDNVMVRHQRIGSNAYCFSASLPPYAVRTASTVLQMMDEDNSSVTKLRYLSNKLHEWF 423
G G Y FS SLPP V S L ++ E N+ V + + +WF
Sbjct: 246 TTGP---------GPLPYLFSNSLPPAVVGCTSKALDLLMESNTIVQSMAART----QWF 292
Query: 424 QTDTE 428
+ E
Sbjct: 293 CSKME 297
>7291697 [H] KOG1360 5-aminolevulinate synthase
Length = 539
Score = 98.2 bits (243), Expect = 3e-20
Identities = 73/271 (26%), Positives = 126/271 (45%), Gaps = 15/271 (5%)
Query: 150 CSFNFLQLSKHPRVVEIAKEIIKNYGVGSCGPAGFYGNEDVHYNLEYDLASFFGTENSVL 209
CS ++L +S HP V ++ + +G G+ G GN H LE LA E ++L
Sbjct: 145 CSNDYLGMSAHPGVKRAVQDALNRHGSGAGGTRNISGNSLHHERLESKLAELHQKEAALL 204
Query: 210 YGQDFCVSSSVIPAFTK--RGDVIVADDKISVSSQNALQLSRSTVYYYKHNDMASLENLL 267
+ F + S + K G I +D S ++ S + ++HND+ L LL
Sbjct: 205 FTSCFVANDSTLFTLAKLLPGCEIFSDAGNHASMIMGIRNSGVPKHIFRHNDVDHLHQLL 264
Query: 268 HELDEAEKKEKLPAIPRKFIVTEGIFHRTGEIAPLPELVQLKRKYKYRLFIDETFSIGVL 327
+ D+ ++P K + E + TG I PL EL+ + ++ FIDE ++G+
Sbjct: 265 KQTDK--------SVP-KIVAFETVHSMTGAICPLEELLDVAHEHGAITFIDEVHAVGLY 315
Query: 328 GATGRGLTEYYNINRATSIDITVGSLATAIGSSGGFVLGDNVMVRHQRIGSNAYCFSASL 387
G G G+ E + +DI G+L A G+ GG++ G + +V R + + F+ SL
Sbjct: 316 GDHGAGVGERDGV--LHKMDIISGTLGKAFGNIGGYIAGTHNLVDMIRSYAAGFIFTTSL 373
Query: 388 PPYAVRTASTVLQMMDEDNSSVTKLRYLSNK 418
PP + A + ++ + +LR+L +
Sbjct: 374 PPTVLCGALEAVNILASEEG--RQLRHLHQR 402
>At5g04620 [E] KOG1359 Glycine C-acetyltransferase/2-amino-3-ketobutyrate-CoA
ligase
Length = 469
Score = 90.1 bits (222), Expect = 8e-18
Identities = 67/266 (25%), Positives = 117/266 (43%), Gaps = 38/266 (14%)
Query: 153 NFLQLSKHPRVVEIAKEIIKNYGVGSCGPAGFYGNEDVHYNLEYDLASFFGTENSVLYGQ 212
++L LS HP + A +K YG+G G A G H LE LA E+ ++
Sbjct: 111 DYLGLSSHPTISNAAANAVKEYGMGPKGSALICGYTTYHRLLESSLAQLKKKEDCLVCPT 170
Query: 213 DFCVSSSVIPAFTKRGDVIVA------DDKISVSSQN------------ALQLSRSTVYY 254
F + + + A ++ A ++K+++ S A + V+
Sbjct: 171 GFAANMAAMVAIGSVASLLAASGKPLKNEKVAIFSDALNHASIIDGVRLAERQGNVEVFV 230
Query: 255 YKHNDMASLENLLHELDEAEKKEKLPAIPRKFIVTEGIFHRTGEIAPLPELVQLKRKYKY 314
Y+H D+++ + + RK +VT+ +F G+ AP+ EL QL++KY +
Sbjct: 231 YRHCDISNCK-----------------MKRKVVVTDSLFSMDGDFAPMEELSQLRKKYGF 273
Query: 315 RLFIDETFSIGVLGATGRGLTEYYNINRATSIDITVGSLATAIGSSGGFVLGDNVMVRHQ 374
L ID+ V G G G+ E +N +D+ VG+L+ A G GGF+ +
Sbjct: 274 LLVIDDAHGTFVCGENGGGVAEEFNCE--ADVDLCVGTLSKAAGCHGGFIACSKKWKQLI 331
Query: 375 RIGSNAYCFSASLP-PYAVRTASTVL 399
+ ++ FS ++P P A + V+
Sbjct: 332 QSRGRSFIFSTAIPVPMAAAAYAAVV 357
>CE06500 [E] KOG1359 Glycine C-acetyltransferase/2-amino-3-ketobutyrate-CoA
ligase
Length = 366
Score = 82.8 bits (203), Expect = 1e-15
Identities = 73/266 (27%), Positives = 105/266 (39%), Gaps = 66/266 (24%)
Query: 148 NLCSFNFLQLSKHPRVVEIAKEIIKNYGVGSCGPAGFYGNEDVHYNLEYDLASFFGTENS 207
N C+ N+L LS HP V+ ++ ++ +G G G +D+H LE +A F GTE++
Sbjct: 71 NFCANNYLGLSSHPEVIAAGQKALETHGAGLSSVRFICGTQDIHKELEQKIAQFHGTEDT 130
Query: 208 VLYGQDFCVSSSVIPAFTKRGDVIVADDKISVSSQNALQLSRSTVYYYKHNDMASLENLL 267
+LY F + S R +IV D S+ D+A L
Sbjct: 131 ILYAACFDANDS-------RFRLIVTDGVFSMD-----------------GDVAPL---- 162
Query: 268 HELDEAEKKEKLPAIPRKFIVTEGIFHRTGEIAPLPELVQLKRKYKYRLFIDETFSIGVL 327
G+I L E KY LFIDE + G
Sbjct: 163 -----------------------------GDITSLAE------KYNALLFIDECHATGFF 187
Query: 328 GATGRGLTEYYNINRATSIDITVGSLATAIGSSGGFVLGDNVMVRHQRIGSNAYCFSASL 387
G TGRG E R I+ T+G GS GG+ G ++ R S Y FS SL
Sbjct: 188 GKTGRGTAEAVG-GRPDVINSTLGKALG--GSMGGYTTGPKPLIDLLRQRSRPYLFSNSL 244
Query: 388 PPYAVRTASTVLQMMDEDNSSVTKLR 413
P V ++ V ++ D+S + L+
Sbjct: 245 APSIVGSSIKVFDLLMNDSSFIGSLQ 270
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.319 0.136 0.393
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,968,298
Number of Sequences: 60738
Number of extensions: 1269516
Number of successful extensions: 3362
Number of sequences better than 1.0e-05: 27
Number of HSP's better than 0.0 without gapping: 21
Number of HSP's successfully gapped in prelim test: 6
Number of HSP's that attempted gapping in prelim test: 3279
Number of HSP's gapped (non-prelim): 31
length of query: 555
length of database: 30,389,216
effective HSP length: 111
effective length of query: 444
effective length of database: 23,647,298
effective search space: 10499400312
effective search space used: 10499400312
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)