ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactI2899 good T KOG3979 Signal transduction mechanisms FGF receptor activating protein 1
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactI2899 969982 967052 -977
(977 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YCR017c_1 [T] KOG3979 FGF receptor activating protein 1 543 e-154
SPAC589.12 [T] KOG3979 FGF receptor activating protein 1 352 1e-96
Hs7657102 [T] KOG3979 FGF receptor activating protein 1 70 1e-11
CE01067 [T] KOG3979 FGF receptor activating protein 1 52 5e-06
>YCR017c_1 [T] KOG3979 FGF receptor activating protein 1
Length = 543
Score = 543 bits (1400), Expect = e-154
Identities = 277/579 (47%), Positives = 358/579 (60%), Gaps = 46/579 (7%)
Query: 1 MVSIRGSVIAWTHTVCAASAFIAALVVGYTLHFEKIVANAWYRYPDEWFPSVSATIGDRY 60
M+ I G +I HT+CA SAF AALV GY+LHF KIV NA Y YPDEWFPSVSATIGDRY
Sbjct: 1 MLIINGKIIPIAHTICAFSAFFAALVTGYSLHFHKIVTNAHYTYPDEWFPSVSATIGDRY 60
Query: 61 PERSIFQILIALTALPRFLLLFTHYYLNRSLFTLLVGIVRTITCGGWVYITSTDDHDAHD 120
PERSIFQILIALTA PRFLLL HYYLN+S LVG++RT++CGGWVYITSTDDHD HD
Sbjct: 61 PERSIFQILIALTAFPRFLLLLGHYYLNQSKVCFLVGVLRTVSCGGWVYITSTDDHDIHD 120
Query: 121 VFMISYIVLTIPWDYMIIKHSQ--YKEWKKILMTAFFGTLIPLIYWFIQHQVHRRAGAYS 178
+FMI+YIVLT+PWD MI ++S + K + T FFGTL P+IYW+IQH V +RAGAYS
Sbjct: 121 IFMITYIVLTLPWDIMITRYSSPLTSKNKGLTATIFFGTLFPMIYWYIQHSVQQRAGAYS 180
Query: 179 VYAYFEWSLIVLDIAFDALACQDFEQIKISVSDWSATEDENIVVPTEYIVETEEQVDITV 238
+YAYFEWSLI+LDIAFDA A DF++I I ++
Sbjct: 181 IYAYFEWSLILLDIAFDAFAYADFKKIDIVLA---------------------------- 212
Query: 239 TETVEEKLNDSSVEELSDDENI---QQEHSRLLESNDNEITILLKETEDIMYPNDLPVPP 295
EK ++S ++ D I +++ S L +S + ++ E E + +
Sbjct: 213 ---FNEKPGNTSFFQIRDSSPINYGEEKSSELQKSGEKKV-----EKEKPVARSATGSYF 264
Query: 296 SQDSFMYVIVNTFNSFMFWTTVTSLFCMLWHFPLWYMGISGYEAVILSTLSPVFLYIPLV 355
DSF Y++ N FN F+FW+ VTSL C +WHFPLWYMGISGYEA IL L P+FLY+P V
Sbjct: 265 RFDSFFYLLTNIFNGFLFWSNVTSLLCSIWHFPLWYMGISGYEAAILGYLGPIFLYLPFV 324
Query: 356 TVVVDQYGMLLANVFSIGAFFIDTPEXXXXXXXXXXXXIVMTFAXXXXXXXXXXIG-KFS 414
+ QYG+LL + +IGA+ + PE V TF F+
Sbjct: 325 SEAFTQYGVLLGGIIAIGAYIVQMPELRLISVAVGTSITVATFVQNLRYITNAETSFSFA 384
Query: 415 LTWIMGLILSVVVKMGFFTNNPLWAIMNENNGGLNIPGLVVSTLFALITPFTNSCHL-WN 473
LTW++GL+ SV++KMGF+TNNP W I++E NGG N LV++ LF +++P+ NS +
Sbjct: 385 LTWLLGLVASVILKMGFYTNNPTWVILDERNGGYNKTALVLTVLFGMLSPYVNSINFEGK 444
Query: 474 RSKTTTRLPFFRKLLVSTGFGSLVFAIHQSLTDASTLIYWCWEGWNSHKGPLAWPWAGLV 533
R+ KL ++ GFGSL+F IHQ LTD+ST IYW WEG+N GPL WPW L
Sbjct: 445 RNAQAKSASLIGKLFLAVGFGSLLFGIHQLLTDSSTTIYWAWEGYNESHGPLPWPWGALT 504
Query: 534 CVAMIGGALTGKQ---SSRTISMTLAISTLALAVPQVKE 569
C M+ +L+ + + L IST L+ + +
Sbjct: 505 CTVMLFASLSSVKFMGKPLVPCLLLLISTAVLSARSITQ 543
>SPAC589.12 [T] KOG3979 FGF receptor activating protein 1
Length = 688
Score = 352 bits (904), Expect = 1e-96
Identities = 213/652 (32%), Positives = 323/652 (48%), Gaps = 55/652 (8%)
Query: 9 IAWTHTVCAASAFIAALVVGYTLHFEKIVANAWYRYPDEWFPSVSATIGDRYPERSIFQI 68
+A HT+C+ +AF L + H+ ++V N +Y YP+EWFPSVSATIGD YPERS+FQ
Sbjct: 15 VALVHTICSFAAFFIPLALALYTHYYQVVKNEFYGYPEEWFPSVSATIGDWYPERSVFQW 74
Query: 69 LIALTALPRFLLLFTHYYLN-----RSLFTLLVGIVRTITCGGWVYITSTDDHDAHDVFM 123
LIALTA PR L+L + L+ + T +G++RT CGGWVY+TSTDDHD HD+FM
Sbjct: 75 LIALTATPRLLVLLLWFTLSGISRPSVIITTALGVLRTALCGGWVYVTSTDDHDWHDIFM 134
Query: 124 ISYIVLTIPWDYMIIK----HSQYKEWKKILMTAFFGTLIPLIYWFIQHQVHRRAGAYSV 179
I Y++ PW ++ K +S + I F T+ PLIYW+IQH+ GAY+V
Sbjct: 135 IGYLISNAPWFILVSKCSPVNSMASRIRNIGSALFVLTIFPLIYWYIQHKFKHIPGAYTV 194
Query: 180 YAYFEWSLIVLDIAFDALACQDFEQIKISVSDWSATEDENIVVPTEYIVETEEQVDITVT 239
YA+FEWSLI+ DI FD+ DF+ + ++ + P+ + +E+ +
Sbjct: 195 YAFFEWSLILWDILFDSALYWDFKPLVFNLHTSKTYSN-----PSSFATRKKEKGE--HL 247
Query: 240 ETVEEKLNDSSVEELSDDENIQQEHSRLLESNDNEITILLKETEDIMYPNDLPVPPSQDS 299
E + + + D N++ ++L S
Sbjct: 248 SYAEAAAVGTQAKNIKKDSNVKCSKKQIL-----------------------------FS 278
Query: 300 FMYVIVNTFNSFMFWTTVTSLFCMLWHFPLWYMGISGYEAVILSTLSPVFLYIPLVTVVV 359
+Y + SF+FW+ +TSL ++W+FPLW+MGISGYEA IL LSP L IPL+
Sbjct: 279 LLYFSSEVYLSFVFWSVLTSLGLLVWYFPLWHMGISGYEACILFELSPFLLGIPLLRKFA 338
Query: 360 DQYGM--LLANVFSIGAFFIDTP--EXXXXXXXXXXXXIVMTFAXXXXXXXXXXIGKFSL 415
+ + L NV I A+ ++ P + T I +
Sbjct: 339 SKVPVIFLFLNVIGIAAYKLEDPVHRLFVTAFSVCCECLAWTSLFSNISPENLAIERKIS 398
Query: 416 TWIMGLILSVVVKMGFFTNNPLWAIMNENNGGLNIPGLVVSTLFALITPFTNSCHLWNRS 475
T++ GL+ S + K FF+NNP+W I+NE NGG IP L+V + LI + +
Sbjct: 399 TFLFGLLASSIAKYSFFSNNPIWPILNETNGGKQIPALIVGIIACLIFAIFHVQQTTANA 458
Query: 476 KTTTRLPFFRKLLVSTGFGSLVFAIHQSLTDASTLIYWCWEGWNSHKGPLAWPWAGLVCV 535
+L L + G+++F +H L D++ L+ W W+G+ KGP +P + V
Sbjct: 459 VEHFKLRKITALSAALSLGTVLFCLHTFLCDSTVLMTWSWDGY-PIKGPQPYPHGAVSIV 517
Query: 536 AMIGGALTGK---QSSRTISMTLAISTLALAVPQVKE-WFRFVFGVLPYVVSIIWIIPSY 591
I L QS + + ++ + W ++ G++ +I+ S
Sbjct: 518 VSICAVLVAPYLYQSGAFMLIGFVLACFGSYFMYINHGWCSYLGGLIFTSYVLIYSFAS- 576
Query: 592 FELVNYIQSPGFLSYSFFIYILFVLAHVWTVAYAFVPYGWILREKLPQVLCF 643
+ ++ +F +YIL+ LAHVW VAY FVP G ILRE+ +L F
Sbjct: 577 IRISSFYSPAKVWGGAFLVYILYSLAHVWVVAYEFVPGGPILRERTSYILIF 628
>Hs7657102 [T] KOG3979 FGF receptor activating protein 1
Length = 315
Score = 70.5 bits (171), Expect = 1e-11
Identities = 57/224 (25%), Positives = 104/224 (45%), Gaps = 27/224 (12%)
Query: 4 IRGSVIAWTHTVCAASAFIAALVVGYTLHFEKIVANAWYRYPDEWFPSVSATIGDRYPER 63
+R + + W F ++ HFE VA + PSVS+ IG P+R
Sbjct: 78 LRFTAMVWWAITFPVFGFFFCIIWSLVFHFEYTVATDCG--VPNYLPSVSSAIGGEVPQR 135
Query: 64 SIFQILIALTALPRFLLLFTH--YYLN--------RSLFTLLVG--IVRTITCGGWVYIT 111
+++ I L + PRFL+ F + +YL+ R L L G +V + Y++
Sbjct: 136 YVWRFCIGLHSAPRFLVAFAYWNHYLSCTSPCSCYRPLCRLNFGLNVVENLALLVLTYVS 195
Query: 112 STDDHDAHD----VFMIS---YIVLTIPWDYMIIKHSQYKE------WKKILMTAFFGTL 158
S++D H+ VF+ S +++LT + KH+ +E WK+ L F +
Sbjct: 196 SSEDFTIHENAFIVFIASSLGHMLLTCILWRLTKKHTVSQEDRKSYSWKQRLFIINFISF 255
Query: 159 IPLIYWFIQHQVHRRAGAYSVYAYFEWSLIVLDIAFDALACQDF 202
+ + +H ++ AG Y+++A E+++++ ++AF A DF
Sbjct: 256 FSALAVYFRHNMYCEAGVYTIFAILEYTVVLTNMAFHMTAWWDF 299
>CE01067 [T] KOG3979 FGF receptor activating protein 1
Length = 278
Score = 52.0 bits (123), Expect = 5e-06
Identities = 51/218 (23%), Positives = 91/218 (41%), Gaps = 39/218 (17%)
Query: 18 ASAFIAALVVGYTLHFEKIVANAWYRYPDEWFPSVSATIGDRYPERSIFQILIALTALPR 77
+SA + +++ LHF++ A + + W PS+SA + PE+ I++ILI L PR
Sbjct: 40 SSALLICVILSLLLHFDQ--ATSTHCEVANWLPSISAAVSTYTPEKYIWRILIGLHIGPR 97
Query: 78 FL--LLFTHYYLNRSLFTL--------------LVGIVRTITCGGWVYITSTDDHDAHDV 121
+ + F ++ L L L + ++ I+S++DH H
Sbjct: 98 LVVAIAFRNFLLGSPLRPLTGHKRLRFLCNLACFLNLLENFFLLALTSISSSEDHSLHAK 157
Query: 122 FMISYIVLTIPWDYMIIKHSQYKEW--------------KKILMTAFFGTLIPL---IYW 164
+ + +I YM++ + E KIL A F L +YW
Sbjct: 158 CFGGFAICSI--IYMLLSTWLFNETGRRTATNLGQRSHEYKILGAAIFVLCFFLGAYLYW 215
Query: 165 FIQHQVHRRAGAYSVYAYFEWSLIVLDIAFDALACQDF 202
+H + G Y+++A E+S ++ +I F DF
Sbjct: 216 --RHNTYCEPGIYTLFALVEYSAVLSNIFFHCTLYYDF 251
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.325 0.140 0.441
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 59,193,478
Number of Sequences: 60738
Number of extensions: 2619431
Number of successful extensions: 9082
Number of sequences better than 1.0e-05: 4
Number of HSP's better than 0.0 without gapping: 2
Number of HSP's successfully gapped in prelim test: 2
Number of HSP's that attempted gapping in prelim test: 9066
Number of HSP's gapped (non-prelim): 7
length of query: 977
length of database: 30,389,216
effective HSP length: 116
effective length of query: 861
effective length of database: 23,343,608
effective search space: 20098846488
effective search space used: 20098846488
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)