ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactII0233 good RO KOG2019 General function prediction only Metalloendoprotease HMP1 (insulinase superfamily)
r_klactII0233 good RO KOG2019 Posttranslational modification, protein turnover, chaperones Metalloendoprotease HMP1 (insulinase superfamily)
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactII0233 76609 73664 -982
(982 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YDR430c [RO] KOG2019 Metalloendoprotease HMP1 (insulinase superf... 1230 0.0
SPBC119.17 [RO] KOG2019 Metalloendoprotease HMP1 (insulinase sup... 582 e-166
Hs7657343 [RO] KOG2019 Metalloendoprotease HMP1 (insulinase supe... 536 e-152
7302255 [RO] KOG2019 Metalloendoprotease HMP1 (insulinase superf... 453 e-127
At3g19170 [RO] KOG2019 Metalloendoprotease HMP1 (insulinase supe... 322 2e-87
At1g49630 [RO] KOG2019 Metalloendoprotease HMP1 (insulinase supe... 320 5e-87
Hs7662488 [RO] KOG2019 Metalloendoprotease HMP1 (insulinase supe... 200 1e-50
CE03926 [O] KOG0961 Predicted Zn2+-dependent endopeptidase insul... 86 3e-16
SPAC3H1.02c [O] KOG0961 Predicted Zn2+-dependent endopeptidase i... 83 2e-15
YOL098c [O] KOG0961 Predicted Zn2+-dependent endopeptidase insul... 82 3e-15
>YDR430c [RO] KOG2019 Metalloendoprotease HMP1 (insulinase superfamily)
Length = 989
Score = 1230 bits (3183), Expect = 0.0
Identities = 594/975 (60%), Positives = 741/975 (75%), Gaps = 3/975 (0%)
Query: 1 MFQIRNYATKYAQSRALRKYPVGGVFHGYEVKRLLPVPELKLTAVDLLHNQTGSQHLHID 60
M + + +A+ YAQ++A+RKYPVGG+FHGYEV+R+LPVPEL+LTAVDL+H+QTG++HLHID
Sbjct: 1 MLRFQRFASSYAQAQAVRKYPVGGIFHGYEVRRILPVPELRLTAVDLVHSQTGAEHLHID 60
Query: 61 RDDNNNVFSIGFKTNPPDSTGVPHILEHTTLCGSHKYPVRDPFFKMLNRSLANFMNAMTG 120
RDD NNVFSI FKTNPPDSTGVPHILEHTTLCGS KYPVRDPFFKMLN+SLANFMNAMTG
Sbjct: 61 RDDKNNVFSIAFKTNPPDSTGVPHILEHTTLCGSVKYPVRDPFFKMLNKSLANFMNAMTG 120
Query: 121 HDYTFYPFATTNETDFANLRDVYLDATLNPLLNQQDFLQEGWRLEHTKVDDPNSDIGFKG 180
DYTF+PF+TTN DFANLR VYLD+TLNPLL Q+DF QEGWRLEH + DP S+I FKG
Sbjct: 121 PDYTFFPFSTTNPQDFANLRGVYLDSTLNPLLKQEDFDQEGWRLEHKNITDPESNIVFKG 180
Query: 181 VVYNEMKGQVSNANYYFWIKFQESYYPSLNNSGGDPTKMTDLQYEDLISFHRNNYHPSNA 240
VVYNEMKGQ+SNANYYFW KFQ+S YPSLNNSGGDP K+TDL+Y DL+ FH NYHPSNA
Sbjct: 181 VVYNEMKGQISNANYYFWSKFQQSIYPSLNNSGGDPMKITDLRYGDLLDFHHKNYHPSNA 240
Query: 241 KTFTYGNFDLNNTLQRLNKEYQGYGRRGSKKRELLPIQMKEDVSVETEGQVDPMLPPDKQ 300
KTFTYGN L +TL++LN+++ GYG+R K + L+PI +K+D+ V+ GQ+D MLPP+KQ
Sbjct: 241 KTFTYGNLPLVDTLKQLNEQFSGYGKRARKDKLLMPIDLKKDIDVKLLGQIDTMLPPEKQ 300
Query: 301 IKTSVTWICGKPEDTYQTFXXXXXXXXXXDGHSSPFYQKLIESGLAYDFSVNTGVESQTA 360
K S+TWICG P+DTY TF DGHSS YQKLIESG+ +FSVN+GVE TA
Sbjct: 301 TKASMTWICGAPQDTYDTFLLKVLGNLLMDGHSSVMYQKLIESGIGLEFSVNSGVEPTTA 360
Query: 361 ANFITIGVQGCDEVDSIYEVINKVWEEVL--QNPFEESRIQAIIQQLELSKKDQRADFGL 418
N +T+G+QG +++ + +N +++ +L ++PF+ RI AII+QLELSKKDQ+ADFGL
Sbjct: 361 VNLLTVGIQGVSDIEIFKDTVNNIFQNLLETEHPFDRKRIDAIIEQLELSKKDQKADFGL 420
Query: 419 QLLYSVLPGWVNKTDPFDSLLFDETLERFQEDWATKGDNLFKDLIKEFVISKPVFKFTMK 478
QLLYS+LPGW NK DPF+SLLF++ L+RF+ D TKGD LF+DLI+++++ KP F F+++
Sbjct: 421 QLLYSILPGWTNKIDPFESLLFEDVLQRFRGDLETKGDTLFQDLIRKYIVHKPCFTFSIQ 480
Query: 479 GSETFSQKLDAEEQXXXXXXXXXXXXXXXXVIFERGXXXXXXXXXXXXXSCLPSLQISAI 538
GSE FS+ LD EEQ IF+RG SCLP+LQI I
Sbjct: 481 GSEEFSKSLDDEEQTRLREKITALDEQDKKNIFKRGILLQEKQNEKEDLSCLPTLQIKDI 540
Query: 539 PRVSKTYPLLEKDNVLNRITDTNGITYVRGKRLLNHHIPRELYPFLPLYADSLTNLGTST 598
PR Y + +K+N ++RITDTNGITYVRGKRLLN IP EL+P+LPL+A+SLTNLGT+T
Sbjct: 541 PRAGDKYSIEQKNNTMSRITDTNGITYVRGKRLLNDIIPFELFPYLPLFAESLTNLGTTT 600
Query: 599 EEFSTIEEQIKLHTGGVSTRVSVNPDAQTGKPMLLFQVDGWALNSKTDHIFKFWKKLLCE 658
E FS IE+QIKLHTGG+ST V V D T +P L+F DGW+LNSKTDHIF+FW K+L E
Sbjct: 601 ESFSEIEDQIKLHTGGISTHVEVTSDPNTTEPRLIFGFDGWSLNSKTDHIFEFWSKILLE 660
Query: 659 TDFHKHKEKLKVLIRSLASSNTASVAETGHAFARNFGAAHLSVTKAINESLNGIEQLQLI 718
TDFHK+ +KLKVLIR LASSNT+SVA+ GHAFAR + AAH + AINE+LNGIEQLQ I
Sbjct: 661 TDFHKNSDKLKVLIRLLASSNTSSVADAGHAFARGYSAAHYRSSGAINETLNGIEQLQFI 720
Query: 719 NKLSQCLDDEALFEKEVVSKLVELQSYINGSSDMKFMITSDSQVQIDAVHQQITGFLSSL 778
N+L LD+E F++EVV KL ELQ YI +++M F ITSDS VQ V QI+ F+ L
Sbjct: 721 NRLHSLLDNEETFQREVVDKLTELQKYIVDTNNMNFFITSDSDVQAKTVESQISKFMERL 780
Query: 779 PKDS-KPCDFYSENYSMLENPGKPTLLQFPFQVHYTAKCYPGVSYTHPDGAKLQILSNML 837
P S P + +Y ++ + K TL++FPFQVHYT++ GV YTH DG+ LQ++SNML
Sbjct: 781 PHGSCLPNGPKTSDYPLIGSKCKHTLIKFPFQVHYTSQALLGVPYTHKDGSALQVMSNML 840
Query: 838 THKYLHREIREKXXXXXXXXXXSALDGTFSFYSYRDPHALNSLSTFDSVPEFILNKSSWG 897
T K+LHRE+REK SAL G FSFYSYRDP L SL TF + +ILN + WG
Sbjct: 841 TFKHLHREVREKGGAYGGGASYSALAGIFSFYSYRDPQPLKSLETFKNSGRYILNDAKWG 900
Query: 898 EPDLNEAKLSVFQQVDSPMSAKNEGTILFHYDVTDEMKQRRREQLLDVNLNDIHQVAEEY 957
DL+EAKL++FQQVD+P S K EG F VTD+MKQ RREQLLDV+L D+H+VAE+Y
Sbjct: 901 VTDLDEAKLTIFQQVDAPKSPKGEGVTYFMSGVTDDMKQARREQLLDVSLLDVHRVAEKY 960
Query: 958 LKQDKSIASIVGPEI 972
L + +++++GP I
Sbjct: 961 LLNKEGVSTVIGPGI 975
>SPBC119.17 [RO] KOG2019 Metalloendoprotease HMP1 (insulinase superfamily)
Length = 882
Score = 582 bits (1501), Expect = e-166
Identities = 334/862 (38%), Positives = 489/862 (55%), Gaps = 21/862 (2%)
Query: 22 VGGVFHGYEVKRLLPVPELKLTAVDLLHNQTGSQHLHIDRDDNNNVFSIGFKTNPPDSTG 81
VG H + V VPEL+L L H T + +H+DR+D N+VFSIGF+T + G
Sbjct: 29 VGDKVHDFRVVDTKKVPELQLNYTRLKHEPTNADMIHLDREDPNSVFSIGFQTPAENDEG 88
Query: 82 VPHILEHTTLCGSHKYPVRDPFFKMLNRSLANFMNAMTGHDYTFYPFATTNETDFANLRD 141
+PHILEHTTLCGS+KYPVRDPFFKMLNRSLA FMNA T D+TFYPFAT N TD+ NLRD
Sbjct: 89 IPHILEHTTLCGSNKYPVRDPFFKMLNRSLATFMNAFTASDFTFYPFATVNTTDYKNLRD 148
Query: 142 VYLDATLNPLLNQQDFLQEGWRLEHTKVDDPNSDIGFKGVVYNEMKGQVSNANYYFWIKF 201
VYLDATL P L + DFLQEGWR EH V+D S I F GVVYNEMKGQVS+++Y F++ F
Sbjct: 149 VYLDATLFPKLRKLDFLQEGWRFEHADVNDKKSPIIFNGVVYNEMKGQVSDSSYIFYMLF 208
Query: 202 QESYYPSLN---NSGGDPTKMTDLQYEDLISFHRNNYHPSNAKTFTYGNFDLNNTLQRLN 258
Q+ + NSGGDP + DL+YE+L+ FHR++YHPSNAK +YG+F L + L L+
Sbjct: 209 QQHLFQGTAYGFNSGGDPLAIPDLKYEELVKFHRSHYHPSNAKILSYGSFPLEDNLSALS 268
Query: 259 KEYQGYGRRGSKKRELLPIQMKEDVSVETEGQVDPMLPPDKQIKTSVTWICGKPEDTYQT 318
+ ++ + +R + ++ V G +DP++ P +Q+KTS++++ + Y+T
Sbjct: 269 ETFRPFSKRELNLPNTFLKEFDQEKRVVEYGPLDPVMAPGRQVKTSISFLANDTSNVYET 328
Query: 319 FXXXXXXXXXXDGHSSPFYQKLIESGLAYDFSVNTGVESQTAANFITIGVQGCDE--VDS 376
F DG SSPFY+ LIESGL DF+ N+G +S T ++G++G E +
Sbjct: 329 FALKVLSKLCFDGFSSPFYKALIESGLGTDFAPNSGYDSTTKRGIFSVGLEGASEESLAK 388
Query: 377 IYEVINKVWEEVLQNPFEESRIQAIIQQLELSKKDQRADFGLQLLYSVLPGWVNKTDPFD 436
I ++ ++ ++ FE +++AI+ Q+E+S K + A FG+ L S+ W N DP D
Sbjct: 389 IENLVYSIFNDLALKGFENEKLEAILHQMEISLKHKSAHFGIGLAQSLPFNWFNGADPAD 448
Query: 437 SLLFDETLERFQEDWATKGDNLFKDLIKEFVI-SKPVFKFTMKGSETFSQKLDAEEQXXX 495
L F++ +E ++ LF+ LIK++++ +K F FTM S TF Q+L E
Sbjct: 449 WLSFNKQIEWLKQ--KNSDGKLFQKLIKKYILENKSRFVFTMLPSSTFPQRLQEAEAKKL 506
Query: 496 XXXXXXXXXXXXXVIFERGXXXXXXXXXXXXXSCLPSLQISAIPRVSKTYPL--LEKDNV 553
I + SCLP+L +S IP L L+ +
Sbjct: 507 QERTSKLTDEDIAEIEKTSVKLLEAQSTPADTSCLPTLSVSDIPETIDETKLKFLDIAGM 566
Query: 554 LNRITD-TNGITYVRGKRLLNHHIPRELYPFLPLYADSLTNLGTSTEEFSTIEEQIKLHT 612
+ D G+TY+R L + P L P+LP+Y D+ NLGT +E +E QI+ +T
Sbjct: 567 KAQWYDLAAGLTYIR-LLLPLKNFPESLIPYLPVYCDACLNLGTHSESIGDLEHQIRRYT 625
Query: 613 GGVSTRVS-VNPDAQTGKPMLLFQVDGWALNSKTDHIFKFWKKLLCETDFHKHKEKLKVL 671
GG+S S V ++ K L + G+AL+ + + K T+ + +KL ++
Sbjct: 626 GGISISPSAVTNNSDVSKYELGIAISGYALDKNVGKLVELINKAFWNTNL-SNTDKLAIM 684
Query: 672 IRSLASSNTASVAETGHAFARNFGAAHLSVTKAINESLNGIEQLQLINKLSQCLDDEALF 731
+++ S T +AE GH+FA+ A+ L+ +I E L G+ Q++L+++LS+ +E+
Sbjct: 685 LKTSVSGITDGIAEKGHSFAKVSSASGLTEKTSITEQLGGLTQVKLLSQLSR---EESF- 740
Query: 732 EKEVVSKLVELQSYINGSSDMKFMITSDSQVQIDAVHQQITGFLSSLPKDSKPCDFYSEN 791
+V KL ++ + G+S K I + S Q + V + + F+ S + + +
Sbjct: 741 -GPLVEKLTAIREILRGTSGFKAAINA-SPTQHEVVEKALQKFMKSRGVNQQTQTKSTSK 798
Query: 792 YSMLENPGKPTLLQFPFQVHYTAKCYPGVSYTHPDGAKLQILSNMLTHKYLHREIREKXX 851
N K T + PFQ ++ AK GV YTHPDGA LQILS++LTHKYLH EIREK
Sbjct: 799 ERNGINSIK-TYHELPFQTYFAAKSCLGVPYTHPDGAPLQILSSLLTHKYLHGEIREKGG 857
Query: 852 XXXXXXXXSALDGTFSFYSYRD 873
S +DG SF++YRD
Sbjct: 858 AYGAGLSYSGIDGVLSFFTYRD 879
>Hs7657343 [RO] KOG2019 Metalloendoprotease HMP1 (insulinase superfamily)
Length = 1038
Score = 536 bits (1380), Expect = e-152
Identities = 342/1015 (33%), Positives = 521/1015 (50%), Gaps = 73/1015 (7%)
Query: 12 AQSRALRKYPVGGVFHGYEVKRLLPVPELKLTAVDLLHNQTGSQHLHIDRDDNNNVFSIG 71
A RAL+ Y +G HG+ V ++ VPEL LTAV L H+ TG+++LH+ R+D NN+FS+
Sbjct: 33 ACERALQ-YKLGDKIHGFTVNQVTSVPELFLTAVKLTHDDTGARYLHLAREDTNNLFSVQ 91
Query: 72 FKTNPPDSTGVPHILEHTTLCGSHKYPVRDPFFKMLNRSLANFMNAMTGHDYTFYPFATT 131
F+T P DSTGVPHILEHT LCGS KYP R+PFFKMLNRSL+ FMNA T DYT YPF+T
Sbjct: 92 FRTTPMDSTGVPHILEHTVLCGSQKYPCRNPFFKMLNRSLSTFMNAFTASDYTLYPFSTQ 151
Query: 132 NETDFANLRDVYLDATLNPLLNQQDFLQEGWRLEHTKVDDPNSDIGFKGVVYNEMKGQVS 191
N DF NL VYLDAT +P L + DF QEGWRLEH DP + + FKGVV+NEMKG +
Sbjct: 152 NPKDFQNLLSVYLDATFSPCLRELDFWQEGWRLEHENPSDPQTPLVFKGVVFNEMKGAFT 211
Query: 192 NANYYFWIKFQESYYPSLNN---SGGDPTKMTDLQYEDLISFHRNNYHPSNAKTFTYGNF 248
+ F Q P SGGDP + +L +E L FH +YHPSNA+ FTYGNF
Sbjct: 212 DNERIFSQHLQNRLLPDHTYSVVSGGDPLCIPELTWEQLKQFHATHYHPSNARFFTYGNF 271
Query: 249 DLNNTLQRLNKEYQGYGRRGSKKRELLPIQMKEDVSVETEGQVDP---MLPPDKQIKTSV 305
L L+++++E ++ + ++P Q D E + P P KQ SV
Sbjct: 272 PLEQHLKQIHEEALSKFQK-IEPSTVVPAQTPWDKPREFQITCGPDSFATDPSKQTTVSV 330
Query: 306 TWICGKPEDTYQTFXXXXXXXXXXDGHSSPFYQKLIESGLAYDFSVNTGVESQTAANFIT 365
+++ DT++ F G +SPFY+ LIESGL +FS + G T + +
Sbjct: 331 SFLLPDITDTFEAFTLSLLSSLLTSGPNSPFYKALIESGLGTEFSPDVGYNGYTREAYFS 390
Query: 366 IGVQGCDE--VDSIYEVINKVWEEVLQNPFEESRIQAIIQQLELSKKDQRADFGLQLLYS 423
+G+QG E ++++ +I++ +EV++ E+ RI+A++ ++E+ K Q FGL L
Sbjct: 391 VGLQGIVEKDIETVRSLIDRTIDEVVETRIEDDRIEALLHKIEIQMKHQSTSFGLMLTSY 450
Query: 424 VLPGWVNKTDPFDSLLFDETLERFQEDWATKGDNLFKDLIKEFVISKPVFKFTMKGSETF 483
+ W + DP + L L +F++ L + + + F ++ +M+ + +
Sbjct: 451 IASCWNHDGDPVELLKLGNQLAKFRQCLQENPKFLQEKVKQYFKNNQHKLTLSMRPDDKY 510
Query: 484 SQKLDAEEQXXXXXXXXXXXXXXXXVIFERGXXXXXXXXXXXXXSCLPSLQISAIPRVSK 543
+K E I+E+G SCLP+L++S I
Sbjct: 511 HEKQAQVEATKLKQKVEALSPGDRQQIYEKGLELRSQQSKPQDASCLPALKVSDI---EP 567
Query: 544 TYPLLEKDNVLNR--------ITDTNGITYVRGKRLLNHHIPRELYPFLPLYADSLTNLG 595
T P+ E D VL TNG+ Y R LN +P EL P++PL+ LT LG
Sbjct: 568 TIPVTELDVVLTAGDIPVQYCAQPTNGMVYFRAFSSLN-TLPEELRPYVPLFCSILTKLG 626
Query: 596 TSTEEFSTIEEQIKLHTGGVSTRVSVNPD-------AQTGKPMLLFQVDGWALNSKTDHI 648
++ +QI+L TGG+S V PD Q G +LF L+ +
Sbjct: 627 CGLLDYREQAQQIELKTGGMSASPHVLPDDSHMDTYEQVG---VLF--SSLCLDRNLPDM 681
Query: 649 FKFWKKLLCETDFHKHKEKLKVLIRSLASSNTASVAETGHAFARNFGAAHLSVTKAINES 708
+ W ++ F + +E KVL++ A + ++GH +A L+ + E+
Sbjct: 682 MQLWSEIFNNPCF-EEEEHFKVLVKMTAQELANGIPDSGHLYASIRAGRTLTPAGDLQET 740
Query: 709 LNGIEQLQLINKLSQCLDDEALFEKEVVSKLVELQSYINGSSDMKFMITSDSQVQIDAVH 768
+G++Q++L+ ++++ D K ++ KL ++ ++ +M+ + + Q Q+
Sbjct: 741 FSGMDQVRLMKRIAEMTD-----IKPILRKLPRIKKHLLNGDNMRCSVNATPQ-QMPQTE 794
Query: 769 QQITGFLSSLPKDSK------------------------PCDFYSENYSMLENPGKP--- 801
+ + FL S+ + K P ++E KP
Sbjct: 795 KAVEDFLRSIGRSKKERRPVRPHTVEKPVPSSSGGDAHVPHGSQVIRKLVMEPTFKPWQM 854
Query: 802 -TLLQFPFQVHYTAKCYPGVSYTHPDGAKLQILSNMLTHKYLHREIREKXXXXXXXXXXS 860
T PF V+Y +C V YT PD A L+IL+ ++T K+LH EIREK S
Sbjct: 855 KTHFLMPFPVNYVGECIRTVPYTDPDHASLKILARLMTAKFLHTEIREKGGAYGGXAKLS 914
Query: 861 ALDGTFSFYSYRDPHALNSLSTFDSVPEFILNKSSWGEPDLNEAKLSVFQQVDSPMSAKN 920
+G F+ YSYRDP+ + +L +F ++ + + D++EAKLSVF VD+P++ +
Sbjct: 915 H-NGIFTLYSYRDPNTIETLQSFGKAVDW-AKSGKFTQQDIDEAKLSVFSTVDAPVAPSD 972
Query: 921 EGTILFHYDVTDEMKQRRREQLLDVNLNDIHQVAEEYLKQDKSI--ASIVGPEIP 973
+G F Y ++DEMKQ REQL V+ + + V++ YL KS +I+GPE P
Sbjct: 973 KGMDHFLYGLSDEMKQAHREQLFAVSHDKLLAVSDRYLGTGKSTHGLAILGPENP 1027
>7302255 [RO] KOG2019 Metalloendoprotease HMP1 (insulinase superfamily)
Length = 1112
Score = 453 bits (1166), Expect = e-127
Identities = 305/976 (31%), Positives = 477/976 (48%), Gaps = 33/976 (3%)
Query: 19 KYPVGGVFHGYEVKRLLPVPELKLTAVDLLHNQTGSQHLHIDRDDNNNVFSIGFKTNPPD 78
KY G +HG++ +R+ + E +LT+ + +TG++ HIDR+D+NNVFSI F+T P D
Sbjct: 63 KYEEGKTYHGFQCERVEHISEFELTSYTFRYERTGTELWHIDRNDSNNVFSINFRTTPFD 122
Query: 79 STGVPHILEHTTLCGSHKYPVRDPFFKMLNRSLANFMNAMTGHDYTFYPFATTNETDFAN 138
STG+PHILEH +LCGS KYPVRDPFFKMLNRS+A FMNAMTG DYT YPF+T NE DF N
Sbjct: 123 STGLPHILEHLSLCGSQKYPVRDPFFKMLNRSVATFMNAMTGPDYTIYPFSTMNEIDFRN 182
Query: 139 LRDVYLDATLNPLLNQQDFLQEGWRLEHTKVDDPNSDIGFKGVVYNEMKGQVSNANYYFW 198
L+ +YLDA P L DFLQEGWRLE+ + D S + KGVVYNEMKG S F
Sbjct: 183 LQHIYLDAVFRPNLAYFDFLQEGWRLENKDIFDKQSKLVIKGVVYNEMKGAFSENAQVFS 242
Query: 199 IKFQESYYPS---LNNSGGDPTKMTDLQYEDLISFHRNNYHPSNAKTFTYGNFDLNNTLQ 255
+ +P + SGG+P ++ L Y DL+ FH+ YHPSNA+ ++YG FD + TL
Sbjct: 243 QNLLNNIFPDHTYRHVSGGNPLEIPKLAYNDLVEFHKKYYHPSNARIYSYGLFDASKTLA 302
Query: 256 RLNKEYQGYGRRGSKKRELLPIQMK--EDVSVETEGQVDPM-LPPDKQIKTSVTWICGKP 312
L++EY L+ Q + + V ++D M D+Q + ++ +
Sbjct: 303 LLDEEYLSDQSWVDNSYSLIRQQERWTQPRLVHISSRLDNMGTTIDRQNQIAIALLMCDA 362
Query: 313 EDTYQTFXXXXXXXXXXDGHSSPFYQKLIESGLAYDFSVNTGVESQTAANFITIGVQG-- 370
+ ++F G +SPFY+ LIE + ++ TG S T +G+Q
Sbjct: 363 TNIQESFELHVLSEVLIRGPNSPFYKNLIEPNFSGGYNQTTGYSSDTKDTTFVVGLQDLR 422
Query: 371 CDEVDSIYEVINKVWEEVLQNPFEESRIQAIIQQLELSKKDQRADFGLQLLYSVLPGWVN 430
++ E+ +K + + F+ +++++ LELS K Q +FG LL++ W +
Sbjct: 423 VEDFKKCIEIFDKTIINSMNDGFDSQHVESVLHNLELSLKHQNPNFGNTLLFNSTALWNH 482
Query: 431 KTDPFDSLLFDETLERFQEDWATKGDNLFKDLIKEFVISKPVFKFTMKGSETFSQKLDAE 490
D +L + + +E + + + K F + TM E + K
Sbjct: 483 DGDVVSNLRVSDMISGLRESISQNKKYFQEKIEKYFANNNHRLTLTMSPDEAYEDKFKQA 542
Query: 491 EQXXXXXXXXXXXXXXXXVIFERGXXXXXXXXXXXXXSCLPSLQISAIPRVSKTYPLLEK 550
E I+ERG LP L ++ + R +P L
Sbjct: 543 ELELVEQKVKLLDEVKIEKIYERGLILDSYQKAESNTDLLPCLTMNDV-RDPPKWPKLFI 601
Query: 551 DNVLNRITD-----TNGITYVRGKRLLN-HHIPRELYPFLPLYADSLTNLGTSTEEFSTI 604
NV N T TN ITY K + N + E +PL+ + ++ +GT+ +
Sbjct: 602 QNVQNVRTQICKVPTNEITYF--KCMFNITGLSHEETQLMPLFCNVISAMGTTNYNYREF 659
Query: 605 EEQIKLHTGGVSTRVSVNPDAQTGKP-MLLFQVDGWALNSKTDHIFKFWKKLLCETDFHK 663
++ I L TGG ++ + D + K L ++ ALN+ +F ++L+ F
Sbjct: 660 DKHILLKTGGFDFKLHLIEDVRDSKSYSLSVMINTHALNNNVPEMFALCQELIKNVRF-D 718
Query: 664 HKEKLKVLIRSLASSNTASVAETGHAFARNFGAAHLSVTKAINESLNGIEQLQLINKLSQ 723
E+LK+LI + S + VA +GH +A + + + L G++ + +
Sbjct: 719 DSERLKMLIENYISYISVGVASSGHLYAMLGATSQVCDAGKLKSLLYGVDHIDFMKNFV- 777
Query: 724 CLDDEALFEKEVVSKLVELQSYINGSSDMKFMITSDSQVQIDAVHQQITGFLSSLPKDSK 783
+ ++ KL + S + +M+ I + + A+ FL SLP K
Sbjct: 778 ----HSTSTVDICDKLSTIASKVFNKDNMRGAINTTQSYEPSAI-SNYEKFLESLPTFGK 832
Query: 784 PCDFYSENYSMLENPGKPTLLQFPFQVHYTAKCYPGVSYTHPDGAKLQILSNMLTHKYLH 843
S N L+ + ++ P V+Y AK V Y H D L++L+ +L+ KYL
Sbjct: 833 TQT--SRNIHYLDPSCQQYVMNIP--VNYCAKALFTVPYLHQDHPTLRVLAKLLSAKYLL 888
Query: 844 REIREKXXXXXXXXXXSALDGTFSFYSYRDPHALNSLSTFDSVPEFI-LNKSSWGEPDLN 902
IREK S+ DG FSFYSYRDP++ +L+ FD +++ N++ + L
Sbjct: 889 PVIREKNGAYGAGAKISS-DGIFSFYSYRDPNSTKTLNAFDETYKWLRANQNVIDQQSLF 947
Query: 903 EAKLSVFQQVDSPMSAKNEGTILFHYDVTDEMKQRRREQLLDVNLNDIHQVAEEYLKQDK 962
E+KL V QQ+D+P++ N G F Y+V+ E + R ++L V ++D+ E Y ++
Sbjct: 948 ESKLGVLQQLDTPIAPGNIGIDYFLYEVSQEDFESYRSRMLSVTIDDLQCAIENYFGKES 1007
Query: 963 SI--ASIVGPEIPNFD 976
I+GP N +
Sbjct: 1008 MHYGKCILGPVNANLE 1023
>At3g19170 [RO] KOG2019 Metalloendoprotease HMP1 (insulinase superfamily)
Length = 1052
Score = 322 bits (824), Expect = 2e-87
Identities = 257/971 (26%), Positives = 433/971 (44%), Gaps = 67/971 (6%)
Query: 37 VPELKLTAVDLLHNQTGSQHLHIDRDDNNNVFSIGFKTNPPDSTGVPHILEHTTLCGSHK 96
+ E K A+ H +TG + + + +D N VF + F+T P DSTG+PHILEH+ LCGS K
Sbjct: 87 ISECKSKAILFKHKKTGCEVMSVSNEDENKVFGVVFRTPPKDSTGIPHILEHSVLCGSRK 146
Query: 97 YPVRDPFFKMLNRSLANFMNAMTGHDYTFYPFATTNETDFANLRDVYLDATLNP--LLNQ 154
YPV++PF ++L SL F+NA T D T YP A+TN DF NL DVYLDA P + +
Sbjct: 147 YPVKEPFVELLKGSLHTFLNAFTYPDRTCYPVASTNTKDFYNLVDVYLDAVFFPKCVDDA 206
Query: 155 QDFLQEGWRLEHTKVDDPNSDIGFKGVVYNEMKGQVSNANYYFWIKFQESYYPSLN---N 211
F QEGW H +++DP+ DI +KGVV+NEMKG S + Q++ P +
Sbjct: 207 HTFQQEGW---HYELNDPSEDISYKGVVFNEMKGVYSQPDNILGRIAQQALSPENTYGVD 263
Query: 212 SGGDPTKMTDLQYEDLISFHRNNYHPSNAKTFTYGNFDLNNTLQRLNKEYQGYGRRGSKK 271
SGGDP + +L +E+ FHR YHPSNA+ + YG+ D + L+ L++ + S
Sbjct: 264 SGGDPKDIPNLTFEEFKEFHRQYYHPSNARIWFYGDDDPVHRLRVLSEYLDMFEASPSPN 323
Query: 272 RELL--------PIQMKEDVSVETEGQVDPMLPPDKQIKTSVTWICG-KPEDTYQTFXXX 322
+ P+++ E +G + K+ V W+ KP D
Sbjct: 324 SSKIKFQKLFSEPVRLVEKYPAGRDGDL------KKKHMLCVNWLLSEKPLDLQTQLALG 377
Query: 323 XXXXXXXDGHSSPFYQKLIESGLAYDFSVNTGVESQTAANFITIGVQGCDE--VDSIYEV 380
+SP + L+ESGL + V++G+ + IG++G E V + E+
Sbjct: 378 FLDHLMLGTPASPLRKILLESGLG-EALVSSGLSDELLQPQFGIGLKGVSEENVQKVEEL 436
Query: 381 INKVWEEVLQNPFEESRIQAIIQQLELSKKDQRADF---GLQLLYSVLPGWVNKTDPFDS 437
I +++ + F+ ++A + +E S ++ GL L+ + W+ DPF+
Sbjct: 437 IMDTLKKLAEEGFDNDAVEASMNTIEFSLRENNTGSFPRGLSLMLQSISKWIYDMDPFEP 496
Query: 438 LLFDETLERFQEDWATKGDN-LFKDLIKEFVISKP-VFKFTMKGSETFSQKLDAEEQXXX 495
L + E L+ + A +G +F LI++ +++ M+ + + + EE+
Sbjct: 497 LKYTEPLKALKTRIAEEGSKAVFSPLIEKLILNNSHRVTIEMQPDPEKATQEEVEEKNIL 556
Query: 496 XXXXXXXXXXXXXVI---FERGXXXXXXXXXXXXXSCLPSLQISAIPRVSKTYPLLEKDN 552
+ E C+PSL + IP+ E
Sbjct: 557 EKVKAAMTEEDLAELARATEELKLKQETPDPPEALRCVPSLNLGDIPK--------EPTY 608
Query: 553 VLNRITDTNGITYVRGKRLLNH-----------HIPRELYPFLPLYADSLTNLGTSTEEF 601
V + D NG+ +R N + EL P +PL+ SL +GT F
Sbjct: 609 VPTEVGDINGVKVLRHDLFTNDIIYTEVVFDIGSLKHELLPLVPLFCQSLLEMGTKDLTF 668
Query: 602 STIEEQIKLHTGGVSTRVSVNPDAQTGKPMLLFQVDGWALNSKTDHIFKFWKKLLCETDF 661
+ + I TGG+S + +P V G ++ + D +F LL E F
Sbjct: 669 VQLNQLIGRKTGGISVYPLTSSVRGKDEPCSKIIVRGKSMAGRADDLFNLMNCLLQEVQF 728
Query: 662 HKHKEKLKVLIRSLASSNTASVAETGHAFARNFGAAHLSVTKAINESLNGIEQLQLINKL 721
+++ K + + + +GH A A L++ ++E + G+ L+ ++ L
Sbjct: 729 -TDQQRFKQFVSQSRARMENRLRGSGHGIAAARMDAMLNIAGWMSEQMGGLSYLEFLHTL 787
Query: 722 SQCLDDEALFEKEVVSKLVELQSYINGSSDMKFMITSDSQVQIDAVHQQITGFLSSLPKD 781
+ +D++ + + S L E++ + + +T+D + + V + + FL LP++
Sbjct: 788 EKKVDED---WEGISSSLEEIRRSLLARNGCIVNMTADGK-SLTNVEKSVAKFLDLLPEN 843
Query: 782 SKPCDFYSENYSMLENPGKPTLLQFPFQVHYTAKCYPGVSYTHPDGAKLQILSNMLTHKY 841
+ L N + P QV+Y K S + ++S +++ +
Sbjct: 844 PSGGLVTWDGRLPLRNEA----IVIPTQVNYVGKAGNIYSTGYELDGSAYVISKHISNTW 899
Query: 842 LHREIREKXXXXXXXXXXSALDGTFSFYSYRDPHALNSLSTFDSVPEFILNKSSWGEPDL 901
L +R + G FS+ SYRDP+ L +L +D +F L + L
Sbjct: 900 LWDRVRVSGGAYGGFCDFDSHSGVFSYLSYRDPNLLKTLDIYDGTGDF-LRGLDVDQETL 958
Query: 902 NEAKLSVFQQVDSPM--SAKNEGTILFH-YDVTDEMKQRRREQLLDVNLNDIHQVAEEY- 957
+A + VDS AK ++L H VTDE +QR+RE++L +L D A+
Sbjct: 959 TKAIIGTIGDVDSYQLPDAKGYSSLLRHLLGVTDEERQRKREEILTTSLKDFKDFAQAID 1018
Query: 958 LKQDKSIASIV 968
+ +DK +A V
Sbjct: 1019 VVRDKGVAVAV 1029
>At1g49630 [RO] KOG2019 Metalloendoprotease HMP1 (insulinase superfamily)
Length = 1076
Score = 320 bits (821), Expect = 5e-87
Identities = 267/972 (27%), Positives = 436/972 (44%), Gaps = 67/972 (6%)
Query: 37 VPELKLTAVDLLHNQTGSQHLHIDRDDNNNVFSIGFKTNPPDSTGVPHILEHTTLCGSHK 96
+ E K AV H +TG + + + DD N VF I F+T P DSTG+PHILEH+ LCGS K
Sbjct: 114 ISECKSKAVLFKHKKTGCEVMSVSNDDENKVFGIVFRTPPKDSTGIPHILEHSVLCGSRK 173
Query: 97 YPVRDPFFKMLNRSLANFMNAMTGHDYTFYPFATTNETDFANLRDVYLDATLNP--LLNQ 154
YP+++PF ++L SL F+NA T D T YP A+TN+ DF NL DVYLDA P + +
Sbjct: 174 YPMKEPFVELLKGSLHTFLNAFTYPDRTCYPVASTNKKDFYNLVDVYLDAVFFPKCVDDV 233
Query: 155 QDFLQEGWRLEHTKVDDPNSDIGFKGVVYNEMKGQVSNA-NYYFWIKFQESYYPSLNNSG 213
F QEGW H +++DP+ DI +KGVV+NEMKG S N E+ Y +SG
Sbjct: 234 HTFQQEGW---HYELNDPSEDISYKGVVFNEMKGVYSQPDNILGRALCPENTYGV--DSG 288
Query: 214 GDPTKMTDLQYEDLISFHRNNYHPSNAKTFTYGNFDLNNTLQRLNK---EYQGYGRRGSK 270
GDP + L +E FHR YHPSNA+ + YG+ D + L+ L++ + R S
Sbjct: 289 GDPKDIPKLTFEKFKEFHRQYYHPSNARIWFYGDDDPVHRLRVLSEYLDMFDASPARDSS 348
Query: 271 KRE-----LLPIQMKEDVSVETEGQVDPMLPPDKQIKTSVTWICG-KPEDTYQTFXXXXX 324
K E P ++ E +G + K+ + W+ KP D
Sbjct: 349 KVEPQKLFSRPRRIVEKYPAGEDGDL------KKKHMVCLNWLLSDKPLDLQTQLALGFL 402
Query: 325 XXXXXDGHSSPFYQKLIESGLAYDFSVNTGVESQTAANFITIGVQGC--DEVDSIYEVIN 382
+SP + L+ESGL + VN+G+E + +IG++G D V + E++
Sbjct: 403 DHLMLGTPASPLRKILLESGLG-EALVNSGMEDELLQPQFSIGLKGVSDDNVQKVEELVM 461
Query: 383 KVWEEVLQNPFEESRIQAIIQQLELSKKDQR---ADFGLQLLYSVLPGWVNKTDPFDSLL 439
++ F+ ++A + +E S ++ + GL L+ + W+ DPF+ L
Sbjct: 462 NTLRKLADEGFDTDAVEASMNTIEFSLRENNTGSSPRGLSLMLQSIAKWIYDMDPFEPLK 521
Query: 440 FDETLERFQEDWATKGD-NLFKDLIKEFVISKP-VFKFTMKGSETFSQKLDAEEQXXXXX 497
++E L+ + A KG ++F LI+E++++ P M+ + +AEE+
Sbjct: 522 YEEPLKSLKARIAEKGSKSVFSPLIEEYILNNPHCVTIEMQPDPEKASLEEAEEKSILEK 581
Query: 498 XXXXXXXXXXXVI---FERGXXXXXXXXXXXXXSCLPSLQISAIPRVSKTYPLLEKDNVL 554
+ E C+PSL +S IP+ E V
Sbjct: 582 VKASMTEEDLTELARATEELRLKQETPDPPDALKCVPSLNLSDIPK--------EPIYVP 633
Query: 555 NRITDTNGITYVRGKRLLNH-----------HIPRELYPFLPLYADSLTNLGTSTEEFST 603
+ D NG+ +R N+ + EL +PL+ SL +GT F
Sbjct: 634 TEVGDINGVKVLRNDLFTNNILYTEVVFDMGSVKHELLQLIPLFCQSLLEMGTQDLTFVQ 693
Query: 604 IEEQIKLHTGGVSTRVSVNPDAQTGKPMLLFQVDGWALNSKTDHIFKFWKKLLCETDFHK 663
+ + I TGG+S + P V G ++ + + +F +L E F
Sbjct: 694 LNQLIGRKTGGISVYPLTSSVYGRDDPCSKIIVRGKSMVGRAEDLFNLMNCVLQEVRF-T 752
Query: 664 HKEKLKVLIRSLASSNTASVAETGHAFARNFGAAHLSVTKAINESLNGIEQLQLINKLSQ 723
+++ K + + + +G A A L+V ++E + G+ L+ ++ L Q
Sbjct: 753 DQQRFKQFVSQSRARMENRLRGSGQGIAAARMDAMLNVAGWMSEQMGGLSYLEFLHTLEQ 812
Query: 724 CLDDEALFEKEVVSKLVELQSYINGSSDMKFMITSDSQVQIDAVHQQITGFLSSLPKDSK 783
+D + + + S L E++ + +T+D + + + + FL LP++
Sbjct: 813 KVDQD---WEGISSSLEEIRRSFLSRNGCIVNMTADGK-SLTNTEKYVGKFLDLLPENPS 868
Query: 784 PCDFYSENYSMLENPGKPTLLQFPFQVHYTAKCYPGVSYTHPDGAKLQILSNMLTHKYLH 843
+ + + + P + + P QV+Y K S + ++S +++ +L
Sbjct: 869 G-ELVTWDARL---PLRNEAIVIPTQVNYVGKAGNIYSSGYKLDGSSYVISKHISNTWLW 924
Query: 844 REIREKXXXXXXXXXXSALDGTFSFYSYRDPHALNSLSTFDSVPEFILNKSSWGEPDLNE 903
+R + G FSF SYRDP+ L +L +D +F L E L +
Sbjct: 925 DRVRVSGGAYGGSCDFDSHSGVFSFLSYRDPNLLKTLDIYDGTGDF-LRGLDVDEDTLTK 983
Query: 904 AKLSVFQQVDSPM--SAKNEGTILFH-YDVTDEMKQRRREQLLDVNLNDIHQVAEEY-LK 959
A + VDS AK ++L H +VTDE +Q RRE++L +L D + AE
Sbjct: 984 AIIGTIGDVDSYQLPDAKGYTSLLRHLLNVTDEERQIRREEILSTSLKDFKEFAEAIDSV 1043
Query: 960 QDKSIASIVGPE 971
DK +A V +
Sbjct: 1044 SDKGVAVAVASQ 1055
>Hs7662488 [RO] KOG2019 Metalloendoprotease HMP1 (insulinase superfamily)
Length = 595
Score = 200 bits (508), Expect = 1e-50
Identities = 157/587 (26%), Positives = 266/587 (44%), Gaps = 56/587 (9%)
Query: 428 WVNKTDPFDSLLFDETLERFQEDWATKGDNLFKDLIKEFVISKPVFKFTMKGSETFSQKL 487
W + DP + L L +F++ L + + + F ++ +M+ + + +K
Sbjct: 13 WNHDGDPVELLKLGNQLAKFRQCLQENPKFLQEKVKQYFKNNQHKLTLSMRPDDKYHEKQ 72
Query: 488 DAEEQXXXXXXXXXXXXXXXXVIFERGXXXXXXXXXXXXXSCLPSLQISAIPRVSKTYPL 547
E I+E+G SCLP+L++S I T P+
Sbjct: 73 AQVEATKLKQKVEALSPGDRQQIYEKGLELRSQQSKPQDASCLPALKVSDI---EPTIPV 129
Query: 548 LEKDNVLNR--------ITDTNGITYVRGKRLLNHHIPRELYPFLPLYADSLTNLGTSTE 599
E D VL TNG+ Y R LN +P EL P++PL+ LT LG
Sbjct: 130 TELDVVLTAGDIPVQYCAQPTNGMVYFRAFSSLNT-LPEELRPYVPLFCSVLTKLGCGLL 188
Query: 600 EFSTIEEQIKLHTGGVSTRVSVNPD---AQTGKPMLLFQVDGWALNSKTDHIFKFWKKLL 656
++ +QI+L TGG+S V PD T + +LF L+ + + W ++
Sbjct: 189 DYREQAQQIELKTGGMSASPHVLPDDSHMDTYEQGVLF--SSLCLDRNLPDMMQLWSEIF 246
Query: 657 CETDFHKHKEKLKVLIRSLASSNTASVAETGHAFARNFGAAHLSVTKAINESLNGIEQLQ 716
F + +E KVL++ A + ++GH +A L+ + E+ +G++Q++
Sbjct: 247 NNPCF-EEEEHFKVLVKMTAQELANGIPDSGHLYASIRAGRTLTPAGDLQETFSGMDQVR 305
Query: 717 LINKLSQCLDDEALFEKEVVSKLVELQSYINGSSDMKFMITSDSQVQIDAVHQQITGFLS 776
L+ ++++ D K ++ KL ++ ++ +M+ + + Q Q+ + + FL
Sbjct: 306 LMKRIAEMTD-----IKPILRKLPRIKKHLLNGDNMRCSVNATPQ-QMPQTEKAVEDFLR 359
Query: 777 SLPKDSK------------------------PCDFYSENYSMLENPGKP----TLLQFPF 808
S+ + K P ++E KP T PF
Sbjct: 360 SIGRSKKERRPVRPHTVEKPVPSSSGGDAHVPHGSQVIRKLVMEPTFKPWQMKTHFLMPF 419
Query: 809 QVHYTAKCYPGVSYTHPDGAKLQILSNMLTHKYLHREIREKXXXXXXXXXXSALDGTFSF 868
V+Y +C V YT PD A L+IL+ ++T K+LH EIREK S +G F+
Sbjct: 420 PVNYVGECIRTVPYTDPDHASLKILARLMTAKFLHTEIREKGGAYGGGAKLSH-NGIFTL 478
Query: 869 YSYRDPHALNSLSTFDSVPEFILNKSSWGEPDLNEAKLSVFQQVDSPMSAKNEGTILFHY 928
YSYRDP+ + +L +F ++ + + D++EAKLSVF VD+P++ ++G F Y
Sbjct: 479 YSYRDPNTIETLQSFGKAVDW-AKSGKFTQQDIDEAKLSVFSTVDAPVAPSDKGMDHFLY 537
Query: 929 DVTDEMKQRRREQLLDVNLNDIHQVAEEYLKQDKSI--ASIVGPEIP 973
++DEMKQ REQL V+ + + V++ YL KS +I+GPE P
Sbjct: 538 GLSDEMKQAHREQLFAVSHDKLLAVSDRYLGTGKSTHGLAILGPENP 584
>CE03926 [O] KOG0961 Predicted Zn2+-dependent endopeptidase insulinase
superfamily
Length = 995
Score = 85.9 bits (211), Expect = 3e-16
Identities = 89/354 (25%), Positives = 134/354 (37%), Gaps = 26/354 (7%)
Query: 69 SIGFKTNPPDSTGVPHILEHTTLCGSHKYPVRDPFFKMLNRSLANFMNAMTGHDYTFYPF 128
++ F T G+PH LEH GS KYP + + NR LA+ NA T D+T Y
Sbjct: 45 AVSFVTEADSDDGLPHTLEHLVFMGSKKYPFKGVLDVIANRCLADGTNAWTDTDHTAYTL 104
Query: 129 ATTNETDFANLRDVYLDATLNPLLNQQDFLQEGWRLEHTKVDDPNSDIGFKGVVYNEMKG 188
+T F + VY++ L P+L F T+V + GVVY+EM+
Sbjct: 105 STVGSDGFLKVLPVYINHLLTPMLTASQFA--------TEVHHITGEGNDAGVVYSEMQD 156
Query: 189 QVSNANYYFWIKFQESYYPSLN----NSGGDPTKMTD-LQYEDLISFHRNNYHPSNAKTF 243
S K +E YP N ++GG + + E + +H+ YH SN
Sbjct: 157 HESEMESIMDRKTKEVIYPPFNPYAVDTGGRLKNLRESCTLEKVRDYHKKFYHLSNMVVT 216
Query: 244 TYGNFDLNNTLQRLNKEYQGYGRRGSKKRELLPIQMK---EDVSVETEGQVDPMLPPDKQ 300
G D + L+ +N S + P D+ T +V+ +
Sbjct: 217 VCGMVDHDQVLEIMNNV---ENEHMSTVPDHFPKPFSFALSDIKESTVHRVECPTDDASR 273
Query: 301 IKTSVTWICGKPEDTYQTFXXXXXXXXXXDGHSSPFYQK---LIESGLA--YDFSVNTGV 355
V W P D +T S QK L+E LA F + GV
Sbjct: 274 GAVEVAWFAHSPSD-LETHSSLHVLFDYLSNTSVAPLQKDFILLEDPLASSVSFHIAEGV 332
Query: 356 ESQTAANFITIGVQGCDEVDSIYEVINKVWEEVLQNPFEESRIQAIIQQLELSK 409
NF + V+ DE + V E + + F+ R+ +I Q L++
Sbjct: 333 RCDLRLNFAGVPVEKLDECAPKF-FDKTVREHLEEANFDMERMGYLIDQTILNE 385
>SPAC3H1.02c [O] KOG0961 Predicted Zn2+-dependent endopeptidase insulinase
superfamily
Length = 1036
Score = 82.8 bits (203), Expect = 2e-15
Identities = 52/170 (30%), Positives = 79/170 (45%), Gaps = 13/170 (7%)
Query: 74 TNPPDSTGVPHILEHTTLCGSHKYPVRDPFFKMLNRSLANFMNAMTGHDYTFYPFATTNE 133
T D+ G PH LEH GS KYP+ K R+ + +NA T DYT Y + E
Sbjct: 51 TEAHDNLGCPHTLEHLCFMGSKKYPMNGILTKFAGRACGD-INACTDVDYTSYELSAAEE 109
Query: 134 TDFANLRDVYLDATLNPLLNQQDFLQEGWRLEHTKVDDPNSDIGFKGVVYNEMKGQVSNA 193
F L V+ D L+P+L+ + F E + + + GVVY+EM+ S+
Sbjct: 110 DGFLRLLPVFADHILSPILSDEAFCTEVYHINGMGEE--------SGVVYSEMQNTQSSE 161
Query: 194 NYYFWIKFQESYYPSLN----NSGGDPTKMTDLQYEDLISFHRNNYHPSN 239
+ + S YP + +GG P+++ L E + +H+ Y PSN
Sbjct: 162 TDVMFDCMRTSQYPVTSGYYYETGGHPSELRKLSIEKIREYHKEMYVPSN 211
>YOL098c [O] KOG0961 Predicted Zn2+-dependent endopeptidase insulinase
superfamily
Length = 1037
Score = 82.4 bits (202), Expect = 3e-15
Identities = 104/457 (22%), Positives = 183/457 (39%), Gaps = 36/457 (7%)
Query: 37 VPELKLTAVDLLHNQTGSQHLHIDRDDNNNVFS-IGFKTNPPDSTGVPHILEHTTLCGSH 95
VP+ +T + +T Q +HI+ + V T + +G PH LEH GS
Sbjct: 14 VPQYHITKY--ISERTKLQLVHINHKTSPLVHGYFAVPTECLNDSGAPHTLEHLIFMGSK 71
Query: 96 KYPVRDPFFKMLNRSLANFMNAMTGHDYTFYPFATTNETDFANLRDVYLDATLNPLLNQQ 155
YP + N SL+N NA T D T Y ++ F+ L YLD L+P L +
Sbjct: 72 SYPYKGLLDTAGNLSLSN-TNAWTDTDQTVYTLSSAGWKGFSKLLPAYLDHILHPTLTDE 130
Query: 156 DFLQEGWRLEHTKVDDPNSDIGFKGVVYNEMKGQVSNANYYFWIKFQESYYPS----LNN 211
L E + + DP ++G KGVV++EM+ + Y ++ Q +P +
Sbjct: 131 ACLTEVYHI------DP-ENLGDKGVVFSEMEAIETQGWYISGLEKQRLMFPEGSGYRSE 183
Query: 212 SGGDPTKMTDLQYEDLISFHRNNYHPSNAKTFTYGNF---DLNNTLQRLNKEYQGYGRRG 268
+GG + L +++ FH++ Y N GN +L ++ + +
Sbjct: 184 TGGLTKNLRTLTNDEIRQFHKSLYSSDNLCVIVCGNVPTDELLTVMEEWDNKLPEIPSNI 243
Query: 269 SKKRELLPIQMK---EDVSVETEGQVDPMLPPDKQIKTSVTWICGKPEDTYQTFXXXXXX 325
KKR L ++ + TE V+ + Q + +WI D
Sbjct: 244 PKKRPFLDNKLSHIPQSRDKVTESTVEFPELDESQGELLFSWIGVPYSDFRNDLAVDVLL 303
Query: 326 XXXXDGHSSPFYQKLIE--SGLAYDFSVNTGVESQTAANFITIGVQGCDEVDSIYEVINK 383
D + F ++L+E +A T +T I + +QG + I K
Sbjct: 304 DYFTDSALAVFTRELVEIDDPMANSTDCCTDYFMRT---IIDLRIQGV-PTEKIAATKTK 359
Query: 384 VWEEVLQNPFEESRIQAIIQQLELS-----KKDQRADFGLQLLYSVLPGWVNKTDPFDSL 438
V E + + + SR++ +++ + +K+ + F ++ + G + + SL
Sbjct: 360 VLEILKTHTIDLSRVRQVVENTKWEYLLNYEKNGESRFSSAVITDYIYGNEDGSSLVSSL 419
Query: 439 L----FDETLERFQEDWATKGDNLFKDLIKEFVISKP 471
FD L+ Q+DW + + +F D V +KP
Sbjct: 420 KDLSDFDALLQWSQKDWQSLLNRIFVDNKPIIVTAKP 456
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.317 0.135 0.395
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 57,953,973
Number of Sequences: 60738
Number of extensions: 2525781
Number of successful extensions: 6111
Number of sequences better than 1.0e-05: 10
Number of HSP's better than 0.0 without gapping: 8
Number of HSP's successfully gapped in prelim test: 2
Number of HSP's that attempted gapping in prelim test: 6047
Number of HSP's gapped (non-prelim): 15
length of query: 982
length of database: 30,389,216
effective HSP length: 116
effective length of query: 866
effective length of database: 23,343,608
effective search space: 20215564528
effective search space used: 20215564528
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)