ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactII0310 good DK KOG3924 Cell cycle control, cell division, chromosome partitioning Putative protein methyltransferase involved in meiosis and transcriptional silencing (Dot1)
r_klactII0310 good DK KOG3924 Transcription Putative protein methyltransferase involved in meiosis and transcriptional silencing (Dot1)
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactII0310 101771 103486 572
(572 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YDR440w [DK] KOG3924 Putative protein methyltransferase involved... 374 e-103
CE03422 [DK] KOG3924 Putative protein methyltransferase involved... 91 6e-18
7298917 [DK] KOG3924 Putative protein methyltransferase involved... 85 3e-16
Hs22053032 [DK] KOG3924 Putative protein methyltransferase invol... 84 8e-16
CE29107 [DK] KOG3924 Putative protein methyltransferase involved... 82 2e-15
CE06555 [DK] KOG3924 Putative protein methyltransferase involved... 82 3e-15
CE07588 [DK] KOG3924 Putative protein methyltransferase involved... 74 5e-13
CE03424 [DK] KOG3924 Putative protein methyltransferase involved... 66 2e-10
>YDR440w [DK] KOG3924 Putative protein methyltransferase involved in meiosis
and transcriptional silencing (Dot1)
Length = 582
Score = 374 bits (959), Expect = e-103
Identities = 218/542 (40%), Positives = 316/542 (58%), Gaps = 18/542 (3%)
Query: 41 TQGKRMTKSTMALIEESMKYDMRSEYFLPMTFLRERRKPARVESDEEDKLAEVKSK---- 96
++G ++K L+EE+ KYD LP FLR+R + ++ L + K
Sbjct: 49 SKGTLLSKQVQNLLEEANKYDPIYGSSLPRGFLRDRNTKGK-----DNGLVPLVEKVIPP 103
Query: 97 --RRVSKKDQVKADIHSTKIKKTGRPSNVKAGAKNTSKVTKQRS-TKSQVSGKKRARSIS 153
++ + ++ K +TK K +P K KN K +K ++ + + +
Sbjct: 104 IHKKTNNRNTRKKSSTTTK-KDVKKPKAAKVKGKNGRTNHKHTPISKQEIDTAREKKPLK 162
Query: 154 DGKVSSIXXXXXXXXXXXXXXXXXXXXFLSNIEENVNPRPSFFNTTLIANPSSFTNKLTS 213
G+ + + ++ T I + S TN
Sbjct: 163 KGRANKKNDRDSPSSTFVDWNGPCLRLQYPLFDIEYLRSHEIYSGTPIQSISLRTNSPQP 222
Query: 214 SKMFVDDE--EVTSLKGMKYILFPGVEEEYLICSKVQKFGYNPLPEIGQSIESAVLLYFP 271
+ + D++ VT+ K ++ ILF EEY + K YNP+ EIG+ IE + L++ P
Sbjct: 223 TSLTSDNDTSSVTTAK-LQSILFSNYMEEYKVDFKRSTAIYNPMSEIGKLIEYSCLVFLP 281
Query: 272 NTYKTKGQE-LVRSLNDAFERSDDQSFEKIVLKYNDLISTIPRDLIVKNLSSNPDVPVSF 330
+ Y + +E ++ LN +F+ SD + F + YN +I IPR I+ +L + +P SF
Sbjct: 282 SPYAEQLKETILPDLNASFDNSDTKGFVNAINLYNKMIREIPRQRIIDHLETIDKIPRSF 341
Query: 331 VHFLLHTCYTRAIYPHARKLKKYTSFSNFVYGELMPDFLTIVFKKCGLNSNSIFMDLGSG 390
+H LH YTR+I+P A KLK Y +FSN+VYGEL+P+FL+ V+++C L FMDLGSG
Sbjct: 342 IHDFLHIVYTRSIHPQANKLKHYKAFSNYVYGELLPNFLSDVYQQCQLKKGDTFMDLGSG 401
Query: 391 VGNCVIQASLEFGCKLSFGCEIMDSASDMAELQLKELKSRCDLWGINLPPIDFSLRKSFV 450
VGNCV+QA+LE GC LSFGCEIMD ASD+ LQ +ELK RC L+G+ L ++FSL+KSFV
Sbjct: 402 VGNCVVQAALECGCALSFGCEIMDDASDLTILQYEELKKRCKLYGMRLNNVEFSLKKSFV 461
Query: 451 DNERVRELIPQCDVILINNFIFDAPLNKEVEKVVQGLKAGSKIISLKSIRPPGYSINYDD 510
DN RV ELIPQCDVIL+NNF+FD LNK+VEK++Q K G KIISLKS+R Y IN+ +
Sbjct: 462 DNNRVAELIPQCDVILVNNFLFDEDLNKKVEKILQTAKVGCKIISLKSLRSLTYQINFYN 521
Query: 511 MDNIFNRLHVESFKLPENSVSWTYRSVGDYYISTVLDAIDESIFCPPILGRIRKKESIKY 570
++NIFNRL V+ + L E+SVSWT+ S G+YYISTV++ +DES+F P GR + +KY
Sbjct: 522 VENIFNRLKVQRYDLKEDSVSWTH-SGGEYYISTVMEDVDESLFSPAARGRRNRGTPVKY 580
Query: 571 TR 572
TR
Sbjct: 581 TR 582
>CE03422 [DK] KOG3924 Putative protein methyltransferase involved in meiosis
and transcriptional silencing (Dot1)
Length = 374
Score = 90.5 bits (223), Expect = 6e-18
Identities = 77/257 (29%), Positives = 121/257 (46%), Gaps = 12/257 (4%)
Query: 292 SDDQSFEKIVLKYNDLI------STIPRDLIVKNLSSNPDVPVSFVHFLLHTCYTRAIYP 345
+D++ FE + K ND + S IP + +++S P + L H Y AI P
Sbjct: 55 ADERKFEAYIYKLNDRLTQCGMHSRIPPNS--SDVTSGGPCPRNLAISLGHIAYRFAI-P 111
Query: 346 HARKLKKYTSFSNFVYGELMPDFLTIVFKKCGLNSNSIFMDLGSGVGNCVIQASLEFGCK 405
A +L+ Y + S+ +YGE+ + + + + N FMDLGSGVG V + K
Sbjct: 112 DANELRHYAAGSSTIYGEINLEQMASFVDELNIGPNDHFMDLGSGVGQLVSFVAAYAQTK 171
Query: 406 LSFGCEIMDSASDMAELQLKELKSRCDLWGINLPPIDFSLRKSFVDNERVRELIPQCDVI 465
S G EIM + + MA + KS +G + P + SF + V E+ + VI
Sbjct: 172 KSVGVEIMPNLAQMARANEQFSKSLLRHFGKTVNPTRL-VHGSFTSPDIVHEIQNEATVI 230
Query: 466 LINNFIFDAPLNKEVEKVVQGLKAGSKIISLKSIRP-PGYSINYDDMDNIFNRLHVE-SF 523
+NN F A L E++ ++ G++IIS +SI P P + + F R+ E
Sbjct: 231 CVNNIKFSAELKLELKMILSKCADGTRIISSESIAPRPRSQNSTSSRVDEFVRISTERPL 290
Query: 524 KLPENSVSWTYRSVGDY 540
L E++ SWT +V Y
Sbjct: 291 LLVESNTSWTGNTVPFY 307
>7298917 [DK] KOG3924 Putative protein methyltransferase involved in meiosis
and transcriptional silencing (Dot1)
Length = 2237
Score = 84.7 bits (208), Expect = 3e-16
Identities = 62/226 (27%), Positives = 104/226 (45%), Gaps = 4/226 (1%)
Query: 329 SFVHFLLHTCYTRAIYPHARKLKKYTSFSNFVYGELMPDFLTIVFKKCGLNSNSIFMDLG 388
S + +L Y A+ KL +Y FS VYGE + + + K ++ F+DLG
Sbjct: 111 SLLRHILQLVYNAAVLD-PDKLNQYEPFSPEVYGETSYELVQQMLKHVTVSKEDTFIDLG 169
Query: 389 SGVGNCVIQASLEFGCKLSFGCEIMDSASDMAELQLKELKSRCDLWGINLPPIDFSLRKS 448
SGVG V+Q + F K G E D+ + AE + +G ++ L K
Sbjct: 170 SGVGQVVLQMAGSFPLKTCIGIEKADTPARYAERMDVIFRQYMGWFGKRF--CEYKLIKG 227
Query: 449 FVDNERVRELIPQCDVILINNFIFDAPLNKEVEKVVQGLKAGSKIISLKSIRPPGYSINY 508
+ RE I ++ +NNF F ++ ++++ L+ G++++S KS P + I
Sbjct: 228 DFLVDEHRENITSSTLVFVNNFAFGPTVDHQLKERFADLRDGARVVSSKSFCPLNFRITD 287
Query: 509 DDMDNIFNRLHVESFKLPENSVSWTYRSVGDYYISTVLDAIDESIF 554
++ +I +HV + SVSWT + V YY+ + I E F
Sbjct: 288 RNLSDIGTIMHVSEIPPLKGSVSWTCKPV-SYYLHVIDRTILERYF 332
>Hs22053032 [DK] KOG3924 Putative protein methyltransferase involved in meiosis
and transcriptional silencing (Dot1)
Length = 1592
Score = 83.6 bits (205), Expect = 8e-16
Identities = 52/177 (29%), Positives = 88/177 (49%), Gaps = 3/177 (1%)
Query: 378 LNSNSIFMDLGSGVGNCVIQASLEFGCKLSFGCEIMDSASDMAELQLKELKSRCDLWGIN 437
+ + +F+DLGSGVG V+Q + CK +G E D + AE +E + +G
Sbjct: 7 MTDDDLFVDLGSGVGQVVLQVAAATNCKHHYGVEKADIPAKYAETMDREFRKWMKWYGKK 66
Query: 438 LPPIDFSLRKSFVDNERVRELIPQCDVILINNFIFDAPLNKEVEKVVQGLKAGSKIISLK 497
+++L + +E RE I VI +NNF F ++ ++++ +K G +I+S K
Sbjct: 67 --HAEYTLERGDFLSEEWRERIANTSVIFVNNFAFGPEVDHQLKERFANMKEGGRIVSSK 124
Query: 498 SIRPPGYSINYDDMDNIFNRLHVESFKLPENSVSWTYRSVGDYYISTVLDAIDESIF 554
P + IN ++ +I + V + SVSWT + V YY+ T+ I E+ F
Sbjct: 125 PFAPLNFRINSRNLSDIGTIMRVVELSPLKGSVSWTGKPV-SYYLHTIDRTILENYF 180
>CE29107 [DK] KOG3924 Putative protein methyltransferase involved in meiosis
and transcriptional silencing (Dot1)
Length = 1015
Score = 82.0 bits (201), Expect = 2e-15
Identities = 54/194 (27%), Positives = 95/194 (48%), Gaps = 3/194 (1%)
Query: 353 YTSFSNFVYGELMPDFLTIVFKKCGLNSNSIFMDLGSGVGNCVIQASLEFGCKLSFGCEI 412
Y SF++ YGE P+ L + + + +F+DLGSG+G V + CK S G E+
Sbjct: 180 YKSFTSETYGETNPEQLISIIDELNIGPQDVFVDLGSGIGQLVCLTAAYAKCKKSVGIEL 239
Query: 413 MDSASDMAELQLKELKSRCDLWGINLPPIDFSLRKSFVDNERVRELIPQCDVILINNFIF 472
S+ A+ K +G N + ++ F++ + + + + VI INNF F
Sbjct: 240 SQVPSNFAQDLAGYFKKFMSHFGKNHGKFE-HIQGDFLNPKFKQLICEEATVIFINNFAF 298
Query: 473 DAPLNKEVE-KVVQGLKAGSKIISLKSIRPPGYSINYDDMDNIFNRLHVESFKLPENSVS 531
DA L + +++Q LK G++I++ K + I + +I H K E++VS
Sbjct: 299 DAALMLRINTELLQDLKHGTRIVTTKELGTNKKEITFRSTSDINAISHTTELKTTESAVS 358
Query: 532 WTYRSVGDYYISTV 545
WT V ++++T+
Sbjct: 359 WTSSHV-KFWLTTI 371
>CE06555 [DK] KOG3924 Putative protein methyltransferase involved in meiosis
and transcriptional silencing (Dot1)
Length = 365
Score = 81.6 bits (200), Expect = 3e-15
Identities = 58/202 (28%), Positives = 103/202 (50%), Gaps = 3/202 (1%)
Query: 345 PHARKLKKYTSFSNFVYGELMPDFLTIVFKKCGLNSNSIFMDLGSGVGNCVIQASLEFGC 404
P A L+ Y ++ VYGEL + + + + FMDLGSG+G+ V +
Sbjct: 153 PDANVLRHYAVGTSTVYGELHCSQMASFVDQLNMGPSDYFMDLGSGIGHLVNFVAAYART 212
Query: 405 KLSFGCEIMDSASDMAELQLKELKSRCDLWGINLPPIDFSLRKSFVDNERVRELIPQCDV 464
++S G E+MD+ +++AE + + + +G + F + SF +RE+ + V
Sbjct: 213 QMSVGVELMDNLAEIAEKNKEFNERLLNHFGKKVYATRF-IHGSFTSPAVIREIQTKATV 271
Query: 465 ILINNFIFDAPLNKEVEKVVQGLKAGSKIISLKSIRPPGYSINYDDMDNIFNRLHVES-F 523
IL NN FD L ++++++ G K ++IIS + + P + F ++ ES
Sbjct: 272 ILANNVRFDPELKLQLKEILMGCKDRTRIISSEPLVPSRARQTNSRRADDFVKISDESLL 331
Query: 524 KLPENSVSWTYRSVGDYYISTV 545
L +N+VSWT R V +Y++T+
Sbjct: 332 NLVDNNVSWTSRKV-PFYLTTI 352
>CE07588 [DK] KOG3924 Putative protein methyltransferase involved in meiosis
and transcriptional silencing (Dot1)
Length = 292
Score = 74.3 bits (181), Expect = 5e-13
Identities = 59/203 (29%), Positives = 92/203 (45%), Gaps = 6/203 (2%)
Query: 350 LKKYTSFSNFVYGELMPDFLTIVFKKCGLNSNSIFMDLGSGVGNCVIQASLEFGCKLSFG 409
L Y S YGE + L + ++ + ++ IF DLGSGVG V+ S G K S G
Sbjct: 85 LNNYRPHSAETYGETALNQLLSICEELEVGTDDIFADLGSGVGQTVLFLSAFAGVKKSIG 144
Query: 410 CEIMDSASDMAELQLKELKSRCDLWGINLPPIDFSL-RKSFVDNERVRELIPQCDVILIN 468
EIM S AEL S + + P++ L SF+D E V + + ++ +N
Sbjct: 145 FEIMQYPSKCAELNRSHFISL--MKHLGKAPLEIKLIHGSFLDAEAVELITSEATLLFMN 202
Query: 469 NFIFDAPLNKEVEKVVQGLKAGSKIISLKSIRPPGYSINYDD--MDNIFNRLHVESFKLP 526
N FD PL E + + K G++IIS G S + + + + +
Sbjct: 203 NVKFDPPLMLNSENLFKKCKVGTRIISTSEFVNRGRSPEASNAWTSQLASITSTKKLRSV 262
Query: 527 ENSVSWTYRSVGDYYISTVLDAI 549
N+VSWT +Y++T+ A+
Sbjct: 263 SNNVSWT-GLTQQFYLTTIHSAL 284
>CE03424 [DK] KOG3924 Putative protein methyltransferase involved in meiosis
and transcriptional silencing (Dot1)
Length = 383
Score = 65.9 bits (159), Expect = 2e-10
Identities = 51/204 (25%), Positives = 101/204 (49%), Gaps = 5/204 (2%)
Query: 345 PHARKLKK-YTSFSNFVYGELMPDFLTIVFKKCGLNSNSIFMDLGSGVGNCVIQASLEFG 403
P+ +KL + Y FS+ YGE M + + + + LNS+ +F+DLGSG+G V +
Sbjct: 140 PYPKKLNQHYKGFSSETYGETMLEQIGSIVDELKLNSSDVFVDLGSGIGQLVCFVAAYSK 199
Query: 404 CKLSFGCEIMDSASDMAELQLKELKSRCDLWGINLPPIDFSLRKSFVDNERVRELIPQCD 463
K + G E+ ++ A Q K+ + I+ ++ F+ + + +
Sbjct: 200 VKKAVGIELSSVPAEYAVSQGMYFKNLMTFFDKQHGEIEL-IQGDFLHPQFHDLICKEAT 258
Query: 464 VILINNFIFDAPLNKE-VEKVVQGLKAGSKIISLKSIR-PPGYSINYDDMDNIFNRLHVE 521
VI INN+ F+ L + V +++Q G++I+S K + P + M + + +
Sbjct: 259 VIFINNYAFEDDLTRRIVFELLQNCADGTRIVSAKPLSLPRSVASRRHAMSDFGSMSNSR 318
Query: 522 SFKLPENSVSWTYRSVGDYYISTV 545
+ + E++VSWT ++ ++ ++TV
Sbjct: 319 TLRATESNVSWT-SNIVEFTLTTV 341
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.317 0.134 0.377
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,702,994
Number of Sequences: 60738
Number of extensions: 1335538
Number of successful extensions: 4641
Number of sequences better than 1.0e-05: 8
Number of HSP's better than 0.0 without gapping: 3
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 4627
Number of HSP's gapped (non-prelim): 11
length of query: 572
length of database: 30,389,216
effective HSP length: 112
effective length of query: 460
effective length of database: 23,586,560
effective search space: 10849817600
effective search space used: 10849817600
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)