ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactII0408 good F KOG0707 Nucleotide transport and metabolism Guanylate kinase
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactII0408 136371 135781 -197
(197 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YDR454c [F] KOG0707 Guanylate kinase 299 1e-81
7294805 [F] KOG0707 Guanylate kinase 192 2e-49
CE29460 [F] KOG0707 Guanylate kinase 190 9e-49
Hs4504221 [F] KOG0707 Guanylate kinase 188 4e-48
SPBC1198.05 [F] KOG0707 Guanylate kinase 188 5e-48
At2g41880 [F] KOG0707 Guanylate kinase 183 1e-46
At3g57550 [F] KOG0707 Guanylate kinase 179 2e-45
Hs11968025 [T] KOG0609 Calcium/calmodulin-dependent serine prote... 126 2e-29
ECU01g1220 [F] KOG0707 Guanylate kinase 117 1e-26
HsM7706403 [T] KOG0609 Calcium/calmodulin-dependent serine prote... 114 9e-26
Hs21361598 [T] KOG0609 Calcium/calmodulin-dependent serine prote... 114 9e-26
Hs22054637 [T] KOG0609 Calcium/calmodulin-dependent serine prote... 109 2e-24
Hs10863921 [F] KOG0708 Membrane-associated guanylate kinase MAGU... 109 3e-24
7303655 [T] KOG0609 Calcium/calmodulin-dependent serine protein ... 107 8e-24
At3g06200 [F] KOG0707 Guanylate kinase 107 1e-23
Hs4758162 [F] KOG0708 Membrane-associated guanylate kinase MAGUK... 105 5e-23
Hs4505237 [T] KOG0609 Calcium/calmodulin-dependent serine protei... 102 3e-22
7292640 [F] KOG0708 Membrane-associated guanylate kinase MAGUK (... 102 3e-22
Hs4557529 [F] KOG0708 Membrane-associated guanylate kinase MAGUK... 100 1e-21
Hs4557527 [F] KOG0708 Membrane-associated guanylate kinase MAGUK... 98 8e-21
CE27132 [T] KOG0609 Calcium/calmodulin-dependent serine protein ... 98 8e-21
CE27131_2 [T] KOG0609 Calcium/calmodulin-dependent serine protei... 98 8e-21
7290910 [T] KOG0609 Calcium/calmodulin-dependent serine protein ... 97 1e-20
Hs20559073 [T] KOG0609 Calcium/calmodulin-dependent serine prote... 96 2e-20
Hs18765725 [T] KOG0609 Calcium/calmodulin-dependent serine prote... 96 2e-20
Hs14780902 [T] KOG0609 Calcium/calmodulin-dependent serine prote... 96 3e-20
7292641 [F] KOG0708 Membrane-associated guanylate kinase MAGUK (... 93 2e-19
7298713 [T] KOG0609 Calcium/calmodulin-dependent serine protein ... 92 5e-19
CE06728 [T] KOG0609 Calcium/calmodulin-dependent serine protein ... 92 6e-19
Hs4502567_2 [T] KOG0609 Calcium/calmodulin-dependent serine prot... 92 6e-19
HsM4505239 [T] KOG0609 Calcium/calmodulin-dependent serine prote... 91 1e-18
Hs21536464 [T] KOG0609 Calcium/calmodulin-dependent serine prote... 91 1e-18
CE26970 [F] KOG0708 Membrane-associated guanylate kinase MAGUK (... 88 9e-18
7300776 [T] KOG0609 Calcium/calmodulin-dependent serine protein ... 83 2e-16
CE08914 [T] KOG0609 Calcium/calmodulin-dependent serine protein ... 77 1e-14
Hs21389483_2 [F] KOG0707 Guanylate kinase 75 6e-14
CE29125 [T] KOG0609 Calcium/calmodulin-dependent serine protein ... 74 2e-13
Hs17433806_1 [F] KOG0707 Guanylate kinase 56 4e-08
Hs9257195 [R] KOG3209 WW domain-containing protein 55 6e-08
CE06035 [F] KOG0707 Guanylate kinase 48 8e-06
>YDR454c [F] KOG0707 Guanylate kinase
Length = 187
Score = 299 bits (766), Expect = 1e-81
Identities = 151/187 (80%), Positives = 166/187 (88%), Gaps = 1/187 (0%)
Query: 6 MSRPIVISGPSGTGKSTLLKKLFAEYPTSFGFSVSSTTRQPRNGEVNGKDYNFVTVDEFK 65
MSRPIVISGPSGTGKSTLLKKLFAEYP SFGFSVSSTTR PR GEVNGKDYNFV+VDEFK
Sbjct: 1 MSRPIVISGPSGTGKSTLLKKLFAEYPDSFGFSVSSTTRTPRAGEVNGKDYNFVSVDEFK 60
Query: 66 SMIDNKKFIEWAQFSGNYYGTTIESVKEVTNSGKTCILDIDMQGVKSVKQ-TDLNARFLF 124
SMI N +FIEWAQFSGNYYG+T+ SVK+V+ SGKTCILDIDMQGVKSVK +LNARFLF
Sbjct: 61 SMIKNNEFIEWAQFSGNYYGSTVASVKQVSKSGKTCILDIDMQGVKSVKAIPELNARFLF 120
Query: 125 VAPPSVEVLKERLTGRGTETPESLEKRLNAAIAELEYAETGAHDLTVVNDDLDAAYEKLK 184
+APPSVE LK+RL GRGTET ES+ KRL+AA AEL YAETGAHD +VNDDLD AY++LK
Sbjct: 121 IAPPSVEDLKKRLEGRGTETEESINKRLSAAQAELAYAETGAHDKVIVNDDLDKAYKELK 180
Query: 185 QFIFEEE 191
FIF E+
Sbjct: 181 DFIFAEK 187
>7294805 [F] KOG0707 Guanylate kinase
Length = 233
Score = 192 bits (489), Expect = 2e-49
Identities = 94/184 (51%), Positives = 134/184 (72%), Gaps = 1/184 (0%)
Query: 8 RPIVISGPSGTGKSTLLKKLFAEYPTSFGFSVSSTTRQPRNGEVNGKDYNFVTVDEFKSM 67
RP+V+ GPSG+GKSTLLK+LFAE+P++FGFS+S TTR+PR GE +G Y FV E ++
Sbjct: 36 RPLVLCGPSGSGKSTLLKRLFAEFPSTFGFSISHTTRKPREGEEHGVHYYFVERPEMEAA 95
Query: 68 IDNKKFIEWAQFSGNYYGTTIESVKEVTNSGKTCILDIDMQGVKSVKQTDLNARFLFVAP 127
I +FIE A+F+GN YGT+ +V+E+ G+ CILDI+ +GV+ +K+TDLN +F P
Sbjct: 96 IAGDEFIETAEFTGNLYGTSKAAVREIQAQGRVCILDIEQKGVEQIKRTDLNPILIFNNP 155
Query: 128 PSVEVLKERLTGRGTETPESLEKRLNAAIAELEYAETGAHDLTVVND-DLDAAYEKLKQF 186
PS++ L+ RL RG+ET ESL KRLNAA EL+Y T + ++N+ D+D AYE+ + F
Sbjct: 156 PSIKELERRLRKRGSETEESLSKRLNAAQVELDYGLTPGNFHKIINNVDIDVAYEEFRNF 215
Query: 187 IFEE 190
+ +E
Sbjct: 216 VVQE 219
>CE29460 [F] KOG0707 Guanylate kinase
Length = 216
Score = 190 bits (483), Expect = 9e-49
Identities = 97/196 (49%), Positives = 136/196 (68%), Gaps = 3/196 (1%)
Query: 2 FIGRMS-RPIVISGPSGTGKSTLLKKLFAEYPTSFGFSVSSTTRQPRNGEVNGKDYNFVT 60
FI +M RPIV+SGPSG GKST+L + EYP SF FSVS TTRQPR GE +GK Y F
Sbjct: 18 FIRKMPCRPIVLSGPSGGGKSTILTRAMQEYPNSFAFSVSHTTRQPRAGEEHGKHYYFTE 77
Query: 61 VDEFKSMIDNKKFIEWAQFSGNYYGTTIESVKEVTNSGKTCILDIDMQGVKSVKQTDLNA 120
++ + MI N +F+E+A FSGN YGT+ ++V E+ NSGK C+LDI++QGV+++K + L+A
Sbjct: 78 KEKMQEMIKNNEFLEFATFSGNTYGTSKKTVLEIENSGKICVLDIELQGVRNIKNSHLDA 137
Query: 121 RFLFVAPPSVEVLKERLTGRGTETPESLEKRLNAAIAELEYAETG--AHDLTVVNDDLDA 178
R++ + PS+++L+ERL RGTET ESL KRL A +L E D +VNDDL+
Sbjct: 138 RYILIRAPSIKLLEERLRARGTETEESLSKRLQHASEDLVEIEKNPTLFDKVIVNDDLER 197
Query: 179 AYEKLKQFIFEEENKS 194
AY++ + ++ K+
Sbjct: 198 AYKEFVDLLRDDLEKT 213
>Hs4504221 [F] KOG0707 Guanylate kinase
Length = 197
Score = 188 bits (478), Expect = 4e-48
Identities = 99/188 (52%), Positives = 131/188 (69%), Gaps = 1/188 (0%)
Query: 8 RPIVISGPSGTGKSTLLKKLFAEYPTSFGFSVSSTTRQPRNGEVNGKDYNFVTVDEFKSM 67
RP+V+SGPSG GKSTLLK+L E+ FGFSVS TTR PR GE NGKDY FVT + +
Sbjct: 5 RPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRD 64
Query: 68 IDNKKFIEWAQFSGNYYGTTIESVKEVTNSGKTCILDIDMQGVKSVKQTDLNARFLFVAP 127
I FIE A+FSGN YGT+ +V+ V + C+LD+D+QGV+++K TDL ++ V P
Sbjct: 65 IAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQP 124
Query: 128 PSVEVLKERLTGRGTETPESLEKRLNAAIAELEYA-ETGAHDLTVVNDDLDAAYEKLKQF 186
PS+ VL++RL R TET ESL KRL AA A++E + E G D+ ++ND LD AY +LK+
Sbjct: 125 PSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAELKEA 184
Query: 187 IFEEENKS 194
+ EE K+
Sbjct: 185 LSEEIKKA 192
>SPBC1198.05 [F] KOG0707 Guanylate kinase
Length = 202
Score = 188 bits (477), Expect = 5e-48
Identities = 91/178 (51%), Positives = 131/178 (73%), Gaps = 1/178 (0%)
Query: 8 RPIVISGPSGTGKSTLLKKLFAEYPTSFGFSVSSTTRQPRNGEVNGKDYNFVTVDEFKSM 67
+P+V+ GPSG GKSTLLK+L ++ GFSVS TTR PR GE +G DY+FVT +EF+ +
Sbjct: 19 KPVVVFGPSGVGKSTLLKRLLKDHGDKLGFSVSHTTRTPRAGEKDGIDYHFVTKEEFQKL 78
Query: 68 IDNKKFIEWAQFSGNYYGTTIESVKEVTNSGKTCILDIDMQGVKSVKQTDLNARFLFVAP 127
+ +KF+EWA FSGN YGT+I +++E+ K ILDID+QGV VK + ++A+++F+AP
Sbjct: 79 VAEEKFVEWAVFSGNMYGTSIMAIQELEAVNKKAILDIDLQGVLQVKASPIDAQYVFLAP 138
Query: 128 PSVEVLKERLTGRGTETPESLEKRLNAAIAELEYAE-TGAHDLTVVNDDLDAAYEKLK 184
PS+E L+ RL GRGTE ++ +RL A AE+EY+E G D +VNDD++ AY++L+
Sbjct: 139 PSIEQLEVRLRGRGTENESAILQRLERARAEIEYSEKPGNFDALIVNDDVEKAYKQLE 196
>At2g41880 [F] KOG0707 Guanylate kinase
Length = 329
Score = 183 bits (465), Expect = 1e-46
Identities = 94/182 (51%), Positives = 127/182 (69%), Gaps = 1/182 (0%)
Query: 4 GRMSRPIVISGPSGTGKSTLLKKLFAEYPTSFGFSVSSTTRQPRNGEVNGKDYNFVTVDE 63
G +PIVISGPSG GK TL+ L E+P+ FGFSVS TTR PR+ E++G Y+F
Sbjct: 134 GNAEKPIVISGPSGVGKGTLISMLMKEFPSMFGFSVSHTTRSPRSMEMDGVHYHFADKKV 193
Query: 64 FKSMIDNKKFIEWAQFSGNYYGTTIESVKEVTNSGKTCILDIDMQGVKSVKQTDLNARFL 123
+ I + KF+E+A GN YGT+IESV+ VT+SGK CILDID+QG +SV+ + L+A F+
Sbjct: 194 MEKEIKDGKFLEFASVHGNLYGTSIESVEAVTDSGKRCILDIDVQGARSVRASSLDAIFI 253
Query: 124 FVAPPSVEVLKERLTGRGTETPESLEKRLNAAIAEL-EYAETGAHDLTVVNDDLDAAYEK 182
FV PPS++ L++RL RGTET E ++KRL A AE+ E +G L + ND+L+ Y+K
Sbjct: 254 FVCPPSMKELEDRLRARGTETEEQIQKRLRNAEAEIKEGISSGIFGLILYNDNLEECYKK 313
Query: 183 LK 184
LK
Sbjct: 314 LK 315
>At3g57550 [F] KOG0707 Guanylate kinase
Length = 391
Score = 179 bits (455), Expect = 2e-45
Identities = 93/185 (50%), Positives = 126/185 (67%), Gaps = 1/185 (0%)
Query: 4 GRMSRPIVISGPSGTGKSTLLKKLFAEYPTSFGFSVSSTTRQPRNGEVNGKDYNFVTVDE 63
G +PIVISGPSG GK TL+ L E+P+ FGFSVS TTR PR E NG Y+F
Sbjct: 135 GNAEKPIVISGPSGVGKGTLISMLMKEFPSMFGFSVSHTTRAPRCMEKNGVHYHFTDKTV 194
Query: 64 FKSMIDNKKFIEWAQFSGNYYGTTIESVKEVTNSGKTCILDIDMQGVKSVKQTDLNARFL 123
+ I + KF+E+A GN YGT+IESV+ VT+SGK CILDID+QG +SVK + L+A F+
Sbjct: 195 MEKEIKDGKFLEFASVHGNLYGTSIESVEVVTDSGKRCILDIDVQGARSVKASSLDAIFI 254
Query: 124 FVAPPSVEVLKERLTGRGTETPESLEKRLNAAIAELEYAE-TGAHDLTVVNDDLDAAYEK 182
FV PPS++ L++RL RGTET E ++KRL A AE++ + +G + + ND+L+ Y+
Sbjct: 255 FVCPPSMKELEDRLRARGTETEEQIQKRLRNADAEIKAGKSSGIFEHKLYNDNLEECYKT 314
Query: 183 LKQFI 187
LK +
Sbjct: 315 LKNLL 319
>Hs11968025 [T] KOG0609 Calcium/calmodulin-dependent serine protein
kinase/membrane-associated guanylate kinase
Length = 503
Score = 126 bits (317), Expect = 2e-29
Identities = 70/181 (38%), Positives = 106/181 (57%), Gaps = 2/181 (1%)
Query: 8 RPIVISGPSGTGKSTLLKKLFAEYPTSFGFSVSSTTRQPRNGEVNGKDYNFVTVDEFKSM 67
RPI++ GP G++ L ++L + F +V TTR R+ EV G+DY+FV+ F++
Sbjct: 308 RPIILIGPQNFGQNELRQRLMNKEKDRFASAVPHTTRSRRDQEVAGRDYHFVSRQAFEAD 367
Query: 68 IDNKKFIEWAQFSGNYYGTTIESVKEVTNSGKTCILDIDMQGVKSVKQTDLNARFLFVAP 127
I KFIE +F N YGT+I+SV++V NSGK C+L + Q +K+++ +DL +F+AP
Sbjct: 368 IAAGKFIEHGEFEKNLYGTSIDSVRQVINSGKICLLSLRTQSLKTLRNSDLKPYIIFIAP 427
Query: 128 PSVEVLKERLTGRG-TETPESLEKRLNAAIAELEYAETGAHDLTVVNDDLDAAYEKLKQF 186
PS E L+ L G PE L + + E+E D +VN DLD AY++L +
Sbjct: 428 PSQERLRALLAKEGKNPKPEELREIIEKT-REMEQNNGHYFDTAIVNSDLDKAYQELLRL 486
Query: 187 I 187
I
Sbjct: 487 I 487
>ECU01g1220 [F] KOG0707 Guanylate kinase
Length = 217
Score = 117 bits (292), Expect = 1e-26
Identities = 62/144 (43%), Positives = 96/144 (66%), Gaps = 7/144 (4%)
Query: 10 IVISGPSGTGKSTLLKKLFAEYPTSFGFSVSSTTRQPRNGEVNGKDYNFVTVDEFKSMID 69
+V++GPSG+GKST++ + +++P F FSVS TTR PRNGEVNGKDY FVT +EF+SM++
Sbjct: 40 LVLTGPSGSGKSTIISHVLSKFP--FEFSVSHTTRAPRNGEVNGKDYFFVTTEEFESMVE 97
Query: 70 NKKFIEWAQFSGNYYGTTIESVKEVTNSGKTCILDIDMQGVKSVKQTDLNARFLFVAPPS 129
++ +E+ Q++GNYYGT + ++ N KT ILD++ GV ++ N +++
Sbjct: 98 RQELLEYIQYNGNYYGT---AAAQLRNPSKTVILDLEYDGVLYCRKNCPNFVIIYIYCDK 154
Query: 130 VEVLKERLTGR-GTETPESLEKRL 152
+ ERL R G+E + LE R+
Sbjct: 155 -NIAYERLKKRMGSENKKELEGRM 177
>HsM7706403 [T] KOG0609 Calcium/calmodulin-dependent serine protein
kinase/membrane-associated guanylate kinase
Length = 540
Score = 114 bits (285), Expect = 9e-26
Identities = 61/186 (32%), Positives = 105/186 (55%), Gaps = 6/186 (3%)
Query: 8 RPIVISGPSGTGKSTLLKKLFAEYPTSFGFSVSSTTRQPRNGEVNGKDYNFVTVDEFKSM 67
+ +V+ G G G+ +L + PT FG +V T+R+PR E +G+ Y FV+ E ++
Sbjct: 339 KTLVLIGAQGVGRRSLKNRFIVLNPTRFGTTVPFTSRKPREDEKDGQAYKFVSRSEMEAD 398
Query: 68 IDNKKFIEWAQFSGNYYGTTIESVKEVTNSGKTCILDIDMQGVKSVKQTDLNARFLFVAP 127
I K++E ++ GN YGT I+S+ EV +G+TCILD++ Q +K ++ ++ +F+A
Sbjct: 399 IKAGKYLEHGEYEGNLYGTKIDSILEVVQTGRTCILDVNPQALKVLRTSEFMPYVVFIAA 458
Query: 128 PSVEVLK---ERLTGRGTETPESLEKRLNAAI---AELEYAETGAHDLTVVNDDLDAAYE 181
P +E L+ + + G T + L + A ++ A DL ++ND+LD A+E
Sbjct: 459 PELETLRAMHKAVVDAGITTKLLTDSDLKKTVDESARIQRAYNHYFDLIIINDNLDKAFE 518
Query: 182 KLKQFI 187
KL+ I
Sbjct: 519 KLQTAI 524
>Hs21361598 [T] KOG0609 Calcium/calmodulin-dependent serine protein
kinase/membrane-associated guanylate kinase
Length = 540
Score = 114 bits (285), Expect = 9e-26
Identities = 61/186 (32%), Positives = 105/186 (55%), Gaps = 6/186 (3%)
Query: 8 RPIVISGPSGTGKSTLLKKLFAEYPTSFGFSVSSTTRQPRNGEVNGKDYNFVTVDEFKSM 67
+ +V+ G G G+ +L + PT FG +V T+R+PR E +G+ Y FV+ E ++
Sbjct: 339 KTLVLIGAQGVGRRSLKNRFIVLNPTRFGTTVPFTSRKPREDEKDGQAYKFVSRSEMEAD 398
Query: 68 IDNKKFIEWAQFSGNYYGTTIESVKEVTNSGKTCILDIDMQGVKSVKQTDLNARFLFVAP 127
I K++E ++ GN YGT I+S+ EV +G+TCILD++ Q +K ++ ++ +F+A
Sbjct: 399 IKAGKYLEHGEYEGNLYGTKIDSILEVVQTGRTCILDVNPQALKVLRTSEFMPYVVFIAA 458
Query: 128 PSVEVLK---ERLTGRGTETPESLEKRLNAAI---AELEYAETGAHDLTVVNDDLDAAYE 181
P +E L+ + + G T + L + A ++ A DL ++ND+LD A+E
Sbjct: 459 PELETLRAMHKAVVDAGITTKLLTDSDLKKTVDESARIQRAYNHYFDLIIINDNLDKAFE 518
Query: 182 KLKQFI 187
KL+ I
Sbjct: 519 KLQTAI 524
>Hs22054637 [T] KOG0609 Calcium/calmodulin-dependent serine protein
kinase/membrane-associated guanylate kinase
Length = 311
Score = 109 bits (273), Expect = 2e-24
Identities = 62/190 (32%), Positives = 103/190 (53%), Gaps = 15/190 (7%)
Query: 8 RPIVISGPSGTGKSTLLKKLFAEYPTSFGFSVSSTTRQPRNGEVNGKDYNFVTVDEFKSM 67
R +V+ GP G G + L +KL +G +V TTR R+ E +G +Y F++ F++
Sbjct: 104 RLVVLVGPVGVGLNELKRKLLISDTQHYGVTVPHTTRARRSQESDGVEYIFISKHLFETD 163
Query: 68 IDNKKFIEWAQFSGNYYGTTIESVKEVTNSGKTCILDIDMQGVKSVKQTDLNARFLFVAP 127
+ N KFIE+ ++ NYYGT+I+SV+ V K C+LD+ VK ++ + +F+ P
Sbjct: 164 VQNNKFIEYGEYKNNYYGTSIDSVRSVLAKNKVCLLDVQPHTVKHLRTLEFKPYVIFIKP 223
Query: 128 PSVEVLKER------LTGRGTE------TPESLEKRLNAA-IAELEYAETGAHDLTVVND 174
PS+E L+E ++ R + T E ++ + +A I E +Y D ++ND
Sbjct: 224 PSIERLRETRKNAKIISSRDDQGAAKPFTEEDFQEMIKSAQIMESQYGH--LFDKIIIND 281
Query: 175 DLDAAYEKLK 184
DL A+ +LK
Sbjct: 282 DLTVAFNELK 291
>Hs10863921 [F] KOG0708 Membrane-associated guanylate kinase MAGUK (contains
PDZ SH3 HOOK and GUK domains)
Length = 817
Score = 109 bits (272), Expect = 3e-24
Identities = 71/192 (36%), Positives = 105/192 (53%), Gaps = 13/192 (6%)
Query: 7 SRPIVISGPSGTGKSTLLKKLFAEYPTSFGFSVSSTTRQPRNGEVNGKDYNFVTV-DEFK 65
+RP++I GP K + L +E+P FG V TTR R+ EV+G+DY+FV ++ +
Sbjct: 627 ARPVIILGPM---KDRVNDDLISEFPHKFGSCVPHTTRPRRDNEVDGQDYHFVVSREQME 683
Query: 66 SMIDNKKFIEWAQFSGNYYGTTIESVKEVTNSGKTCILDIDMQGVKSVKQTDLNARFLFV 125
I + KFIE QF+ N YGT+I+SV+ V GK CILD+ +K ++Q L +F+
Sbjct: 684 KDIQDNKFIEAGQFNDNLYGTSIQSVRAVAERGKHCILDVSGNAIKRLQQAQLYPIAIFI 743
Query: 126 APPSVEVLKERLTGRGTETPESLEKRLNAAI-AELEYAETGAHDLTVVNDDLDAAYEKLK 184
P S+E L E +T E K + A+ E E+ E V D L+ Y K+K
Sbjct: 744 KPKSIEALMEM---NRRQTYEQANKIYDKAMKLEQEFGE--YFTAIVQGDSLEEIYNKIK 798
Query: 185 QFIFEEENKSGN 196
Q I E++SG+
Sbjct: 799 QII---EDQSGH 807
>7303655 [T] KOG0609 Calcium/calmodulin-dependent serine protein
kinase/membrane-associated guanylate kinase
Length = 416
Score = 107 bits (268), Expect = 8e-24
Identities = 63/197 (31%), Positives = 103/197 (51%), Gaps = 12/197 (6%)
Query: 8 RPIVISGPSGTGKSTLLKKLFAEYPTSFGFSVSSTTRQPRNGEVNGKDYNFVTVDEFKSM 67
RPIV+ G G G++ L ++L A P F V TTR R GEV G++Y FV ++ +
Sbjct: 211 RPIVLIGAPGVGRNELRRRLIARDPEKFRSPVPYTTRPMRTGEVAGREYIFVAREKMDAD 270
Query: 68 IDNKKFIEWAQFSGNYYGTTIESVKEVTNSGKTCILDIDMQGVKSVKQTDLNARFLFVAP 127
I+ KF+E ++ G+ YGT+ ESVK + N+G C+L Q +K+++ L + V P
Sbjct: 271 IEAGKFVEHGEYKGHLYGTSAESVKSIVNAGCVCVLSPHYQAIKTLRTAQLKPFLIHVKP 330
Query: 128 PSVEVLKERLTGRGTE-----------TPESLEKRLNAAIAELEYAETGAHDLTVVNDDL 176
P +++LK T + T E E + +A +++ D+ +VN +L
Sbjct: 331 PELDILKATRTEARAKSTFDEANARSFTDEEFEDMIKSA-ERIDFLYGHFFDVELVNGEL 389
Query: 177 DAAYEKLKQFIFEEENK 193
A+E+L Q + EN+
Sbjct: 390 VNAFEQLVQNVQRLENE 406
>At3g06200 [F] KOG0707 Guanylate kinase
Length = 240
Score = 107 bits (266), Expect = 1e-23
Identities = 65/185 (35%), Positives = 106/185 (57%), Gaps = 2/185 (1%)
Query: 10 IVISGPSGTGKSTLLKKLFAEYPTSFGFSVSSTTRQPRNGEVNGKDYNFVTVDEFKSMID 69
IVISGPSG GK ++ KL E F V++T+R R GEV+GKDY FV+ D+F SM++
Sbjct: 49 IVISGPSGVGKDAVINKL-REVREGLHFVVTATSRPMRPGEVDGKDYFFVSRDQFLSMVE 107
Query: 70 NKKFIEWAQFSGNYYGTTIESVKEVTNSGKTCILDIDMQGVKSVKQTDLN-ARFLFVAPP 128
N++ +E+A G Y G + ++E G+ +L +D+QG +++++ N A F+F+
Sbjct: 108 NEELLEYALVYGEYKGIPKKQIQEFMAKGEDIVLRVDIQGAQTLRRILGNSAVFIFLVAE 167
Query: 129 SVEVLKERLTGRGTETPESLEKRLNAAIAELEYAETGAHDLTVVNDDLDAAYEKLKQFIF 188
S + ERL R TE+ E L R+ A E+ + + + + LD A +++ I
Sbjct: 168 SELAMVERLIDRKTESQEELLVRVATAREEVRHLKNFDYVVVNAKGRLDDAVNRVESIID 227
Query: 189 EEENK 193
E++K
Sbjct: 228 AEKSK 232
>Hs4758162 [F] KOG0708 Membrane-associated guanylate kinase MAGUK (contains
PDZ SH3 HOOK and GUK domains)
Length = 926
Score = 105 bits (261), Expect = 5e-23
Identities = 67/185 (36%), Positives = 102/185 (54%), Gaps = 8/185 (4%)
Query: 7 SRPIVISGPSGTGKSTLLKKLFAEYPTSFGFSVSSTTRQPRNGEVNGKDYNFVTV-DEFK 65
+RP++I GP K + L +E+P FG V TTR R+ EV+G+DY+FVT ++ +
Sbjct: 736 TRPVIILGPM---KDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQME 792
Query: 66 SMIDNKKFIEWAQFSGNYYGTTIESVKEVTNSGKTCILDIDMQGVKSVKQTDLNARFLFV 125
I KFIE Q++ + YGT+++SV+EV GK CILD+ +K ++ L +F+
Sbjct: 793 KDIQEHKFIEAGQYNNHLYGTSVQSVREVAGKGKHCILDVSGNAIKRLQIAQLYPISIFI 852
Query: 126 APPSVEVLKERLTGRGTETPESLEKRLNAAIAELEYAETGAHDLTVVNDDLDAAYEKLKQ 185
P S+E + E + R TE E K A+ +LE T V D L+ Y ++KQ
Sbjct: 853 KPKSMENIME-MNKRLTE--EQARKTFERAM-KLEQEFTEHFTAIVQGDTLEDIYNQVKQ 908
Query: 186 FIFEE 190
I E+
Sbjct: 909 IIEEQ 913
>Hs4505237 [T] KOG0609 Calcium/calmodulin-dependent serine protein
kinase/membrane-associated guanylate kinase
Length = 466
Score = 102 bits (255), Expect = 3e-22
Identities = 55/178 (30%), Positives = 98/178 (54%), Gaps = 12/178 (6%)
Query: 8 RPIVISGPSGTGKSTLLKKLFAEYPTSFGFSVSSTTRQPRNGEVNGKDYNFVTVDEFKSM 67
+ +V+ G SG G+S + L ++ P F + V TTR PR E +GK+Y+F++ +E
Sbjct: 283 KTLVLIGASGVGRSHIKNALLSQNPEKFVYPVPYTTRPPRKSEEDGKEYHFISTEEMTRN 342
Query: 68 IDNKKFIEWAQFSGNYYGTTIESVKEVTNSGKTCILDIDMQGVKSVKQTDLNARFLFVAP 127
I +F+E+ + GN +GT E+V ++ K ILDI+ Q +K V+ +L+ +F+AP
Sbjct: 343 ISANEFLEFGSYQGNMFGTKFETVHQIHKQNKIAILDIEPQTLKIVRTAELSPFIVFIAP 402
Query: 128 PSVEVLKERLTGRGTETPESLEKRLNAAIAELEYAETGAHDLTVVNDDLDAAYEKLKQ 185
T +GT+T + + ++ +YA DL++VN+ +D +KL++
Sbjct: 403 ----------TDQGTQTEALQQLQKDSEAIRSQYAH--YFDLSLVNNGVDETLKKLQE 448
>7292640 [F] KOG0708 Membrane-associated guanylate kinase MAGUK (contains
PDZ SH3 HOOK and GUK domains)
Length = 960
Score = 102 bits (255), Expect = 3e-22
Identities = 69/188 (36%), Positives = 102/188 (53%), Gaps = 14/188 (7%)
Query: 7 SRPIVISGPSGTGKSTLLKKLFAEYPTSFGFSVSSTTRQPRNGEVNGKDYNFVTV-DEFK 65
+RP++I GP K + L +EYP FG V TTR R EV+G+DY+FV+ ++ +
Sbjct: 770 TRPVIILGPL---KDRINDDLISEYPDKFGSCVPHTTRPKREYEVDGRDYHFVSSREQME 826
Query: 66 SMIDNKKFIEWAQFSGNYYGTTIESVKEVTNSGKTCILDIDMQGVKSVKQTDLNARFLFV 125
I N FIE Q++ N YGT++ SV+EV GK CILD+ +K ++ L +F+
Sbjct: 827 RDIQNHLFIEAGQYNDNLYGTSVASVREVAEKGKHCILDVSGNAIKRLQVAQLYPVAVFI 886
Query: 126 APPSVEVLKERLTGRGTETPESLEKRLNAAI-AELEYAE--TGAHDLTVVNDDLDAAYEK 182
P SV+ + E + R TE E +K AI E E+ E TG V D ++ Y K
Sbjct: 887 KPKSVDSVME-MNRRMTE--EQAKKTYERAIKMEQEFGEYFTG----VVQGDTIEEIYSK 939
Query: 183 LKQFIFEE 190
+K I+ +
Sbjct: 940 VKSMIWSQ 947
>Hs4557529 [F] KOG0708 Membrane-associated guanylate kinase MAGUK (contains
PDZ SH3 HOOK and GUK domains)
Length = 767
Score = 100 bits (249), Expect = 1e-21
Identities = 65/182 (35%), Positives = 98/182 (53%), Gaps = 8/182 (4%)
Query: 7 SRPIVISGPSGTGKSTLLKKLFAEYPTSFGFSVSSTTRQPRNGEVNGKDYNFVTVDE-FK 65
+RPI+I GP+ K L +E+P FG V TTR R E++G+DY+FV+ E +
Sbjct: 577 ARPIIILGPT---KDRANDDLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKME 633
Query: 66 SMIDNKKFIEWAQFSGNYYGTTIESVKEVTNSGKTCILDIDMQGVKSVKQTDLNARFLFV 125
I KFIE Q++ + YGT+++SV+EV GK CILD+ V+ ++ L+ +F+
Sbjct: 634 KDIQAHKFIEAGQYNSHLYGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFI 693
Query: 126 APPSVEVLKERLTGRGTETPESLEKRLNAAIAELEYAETGAHDLTVVNDDLDAAYEKLKQ 185
P S+E + E + R TE E K + A +LE T V D + Y K+K+
Sbjct: 694 RPRSLENVLE-INKRITE--EQARKAFDRA-TKLEQEFTECFSAIVEGDSFEEIYHKVKR 749
Query: 186 FI 187
I
Sbjct: 750 VI 751
>Hs4557527 [F] KOG0708 Membrane-associated guanylate kinase MAGUK (contains
PDZ SH3 HOOK and GUK domains)
Length = 870
Score = 97.8 bits (242), Expect = 8e-21
Identities = 67/186 (36%), Positives = 101/186 (54%), Gaps = 10/186 (5%)
Query: 7 SRPIVISGPSGTGKSTLLKKLFAEYPTSFGFSVSSTTRQPRNGEVNGKDYNFV-TVDEFK 65
+RP++I GP K + L +E+P FG V TTR R+ EV+G+DY+FV + ++ +
Sbjct: 680 TRPVIILGPM---KDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQME 736
Query: 66 SMIDNKKFIEWAQFSGNYYGTTIESVKEVTNSGKTCILDIDMQGVKSVKQTDLNARFLFV 125
I KFIE Q++ N YGT+++SV+ V GK CILD+ +K ++ L +F+
Sbjct: 737 KDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFI 796
Query: 126 APPSVEVLKERLTGRGTETPESLEKRLNAAI-AELEYAETGAHDLTVVNDDLDAAYEKLK 184
P S+E L E + R TE E +K + AI E E+ E V D L+ Y + K
Sbjct: 797 KPRSLESLME-MNKRLTE--EQAKKTYDRAIKLEQEFGE--YFTAIVQGDTLEDIYNQCK 851
Query: 185 QFIFEE 190
I E+
Sbjct: 852 LVIEEQ 857
>CE27132 [T] KOG0609 Calcium/calmodulin-dependent serine protein
kinase/membrane-associated guanylate kinase
Length = 620
Score = 97.8 bits (242), Expect = 8e-21
Identities = 53/181 (29%), Positives = 96/181 (52%), Gaps = 11/181 (6%)
Query: 8 RPIVISGPSGTGKSTLLKKLFAEYPTSFGFSVSSTTRQPRNGEVNGKDYNFVTVDEFKSM 67
+ +V+ G G G+ + L +P F + + TTR PR EV+GK Y FVT ++ +
Sbjct: 434 KTLVLLGAHGVGRRHIKNTLIHRHPNRFAYPIPHTTRPPRKDEVDGKHYYFVTNEQMMAD 493
Query: 68 IDNKKFIEWAQFSGNYYGTTIESVKEVTNSGKTCILDIDMQGVKSVKQTDLNARFLFVAP 127
I N +++E+ + YGT +E+++ + SGK ILD++ Q +K ++ + + +F+A
Sbjct: 494 IQNNEYLEYGTHEESMYGTKLETIRNIHKSGKIAILDVEPQALKVLRTAEYSPFVVFIAA 553
Query: 128 PSVEVLKERLTGRGTETPE-SLEKRLNAAIAELEYAETGAHDLTVVNDDLDAAYEKLKQF 186
P+++ G + P+ SLEK LN + L A D + N D+D +L++
Sbjct: 554 PNLQ---------GMQDPDGSLEKLLNESDV-LRQAFGHLFDFIITNSDIDDTIAQLERL 603
Query: 187 I 187
+
Sbjct: 604 V 604
>CE27131_2 [T] KOG0609 Calcium/calmodulin-dependent serine protein
kinase/membrane-associated guanylate kinase
Length = 601
Score = 97.8 bits (242), Expect = 8e-21
Identities = 53/181 (29%), Positives = 96/181 (52%), Gaps = 11/181 (6%)
Query: 8 RPIVISGPSGTGKSTLLKKLFAEYPTSFGFSVSSTTRQPRNGEVNGKDYNFVTVDEFKSM 67
+ +V+ G G G+ + L +P F + + TTR PR EV+GK Y FVT ++ +
Sbjct: 415 KTLVLLGAHGVGRRHIKNTLIHRHPNRFAYPIPHTTRPPRKDEVDGKHYYFVTNEQMMAD 474
Query: 68 IDNKKFIEWAQFSGNYYGTTIESVKEVTNSGKTCILDIDMQGVKSVKQTDLNARFLFVAP 127
I N +++E+ + YGT +E+++ + SGK ILD++ Q +K ++ + + +F+A
Sbjct: 475 IQNNEYLEYGTHEESMYGTKLETIRNIHKSGKIAILDVEPQALKVLRTAEYSPFVVFIAA 534
Query: 128 PSVEVLKERLTGRGTETPE-SLEKRLNAAIAELEYAETGAHDLTVVNDDLDAAYEKLKQF 186
P+++ G + P+ SLEK LN + L A D + N D+D +L++
Sbjct: 535 PNLQ---------GMQDPDGSLEKLLNESDV-LRQAFGHLFDFIITNSDIDDTIAQLERL 584
Query: 187 I 187
+
Sbjct: 585 V 585
>7290910 [T] KOG0609 Calcium/calmodulin-dependent serine protein
kinase/membrane-associated guanylate kinase
Length = 794
Score = 97.4 bits (241), Expect = 1e-20
Identities = 60/215 (27%), Positives = 106/215 (48%), Gaps = 39/215 (18%)
Query: 8 RPIVISGPSGTGKSTLLKKLFAEY------------------PTSFGFSVSSTTRQPRNG 49
RPIV+ GP G+ L ++L A+ P V T+R R G
Sbjct: 554 RPIVLIGPPNIGRHELRQRLMADSERFSAAVPLFYLLEERLKPAKIKAQVKDTSRARREG 613
Query: 50 EVNGKDYNFVTVDEFKSMIDNKKFIEWAQFSGNYYGTTIESVKEVTNSGKTCILDIDMQG 109
EV G DY+F+T F++ I ++F+E ++ YYGT++E+++ V SGK C+L++ Q
Sbjct: 614 EVPGVDYHFITRQAFEADILARRFVEHGEYEKAYYGTSLEAIRTVVASGKICVLNLHPQS 673
Query: 110 VKSVKQTDLNARFLFVAPPSVEVLKERLTGRG---------------TETPESLEKR--- 151
+K ++ +DL + VAPPS++ L+++ G T++ +L K+
Sbjct: 674 LKLLRASDLKPYVVLVAPPSLDKLRQKKLRNGEPFKVRFQHSNLSNKTQSKSNLFKQEEE 733
Query: 152 ---LNAAIAELEYAETGAHDLTVVNDDLDAAYEKL 183
+ A ++E D+ ++N+D + AY +L
Sbjct: 734 LKDIIATARDMEARWGHLFDMIIINNDTERAYHQL 768
>Hs20559073 [T] KOG0609 Calcium/calmodulin-dependent serine protein
kinase/membrane-associated guanylate kinase
Length = 552
Score = 96.3 bits (238), Expect = 2e-20
Identities = 52/183 (28%), Positives = 96/183 (52%), Gaps = 6/183 (3%)
Query: 8 RPIVISGPSGTGKSTLLKKLFAEYPTSFGFSVSSTTRQPRNGEVNGKDYNFVTVDEFKSM 67
+ +V+ G G G+ +L KL P +G +V T+R+P++ E G+ Y+FV+ E ++
Sbjct: 351 KTLVLIGAQGVGRRSLKNKLIMWDPDRYGTTVPYTSRRPKDSEREGQGYSFVSRGEMEAD 410
Query: 68 IDNKKFIEWAQFSGNYYGTTIESVKEVTNSGKTCILDIDMQGVKSVKQTDLNARFLFVAP 127
+ +++E ++ GN YGT I+S++ V +GK C+LD++ Q VK ++ + +F+
Sbjct: 411 VRAGRYLEHGEYEGNLYGTRIDSIRGVVAAGKVCVLDVNPQAVKVLRTAEFVPYVVFIEA 470
Query: 128 PSVEVLK---ERLTGRGTETPESLEKRLNAAIAELEYAETG---AHDLTVVNDDLDAAYE 181
P E L+ G T + E L + E + G DL +VN +L+ +
Sbjct: 471 PDFETLRAMNRAALESGISTKQLTEADLRRTVEESSRIQRGYGHYFDLCLVNSNLERTFR 530
Query: 182 KLK 184
+L+
Sbjct: 531 ELQ 533
>Hs18765725 [T] KOG0609 Calcium/calmodulin-dependent serine protein
kinase/membrane-associated guanylate kinase
Length = 552
Score = 96.3 bits (238), Expect = 2e-20
Identities = 52/183 (28%), Positives = 96/183 (52%), Gaps = 6/183 (3%)
Query: 8 RPIVISGPSGTGKSTLLKKLFAEYPTSFGFSVSSTTRQPRNGEVNGKDYNFVTVDEFKSM 67
+ +V+ G G G+ +L KL P +G +V T+R+P++ E G+ Y+FV+ E ++
Sbjct: 351 KTLVLIGAQGVGRRSLKNKLIMWDPDRYGTTVPYTSRRPKDSEREGQGYSFVSRGEMEAD 410
Query: 68 IDNKKFIEWAQFSGNYYGTTIESVKEVTNSGKTCILDIDMQGVKSVKQTDLNARFLFVAP 127
+ +++E ++ GN YGT I+S++ V +GK C+LD++ Q VK ++ + +F+
Sbjct: 411 VRAGRYLEHGEYEGNLYGTRIDSIRGVVAAGKVCVLDVNPQAVKVLRTAEFVPYVVFIEA 470
Query: 128 PSVEVLK---ERLTGRGTETPESLEKRLNAAIAELEYAETG---AHDLTVVNDDLDAAYE 181
P E L+ G T + E L + E + G DL +VN +L+ +
Sbjct: 471 PDFETLRAMNRAALESGISTKQLTEADLRRTVEESSRIQRGYGHYFDLCLVNSNLERTFR 530
Query: 182 KLK 184
+L+
Sbjct: 531 ELQ 533
>Hs14780902 [T] KOG0609 Calcium/calmodulin-dependent serine protein
kinase/membrane-associated guanylate kinase
Length = 637
Score = 95.9 bits (237), Expect = 3e-20
Identities = 53/185 (28%), Positives = 102/185 (54%), Gaps = 10/185 (5%)
Query: 8 RPIVISGPSGTGKSTLLKKLFAEYPTSFGFSVSSTTRQPRNGEVNGKDYNFVTVDEFKSM 67
R IV+ GPSG G + L ++L P+ F +V TTR ++ E+NG++Y++V+ + F+++
Sbjct: 428 RLIVLMGPSGVGVNELRRQLIEFNPSHFQSAVPHTTRTKKSYEMNGREYHYVSKETFENL 487
Query: 68 IDNKKFIEWAQFSGNYYGTTIESVKEVTNSGKTCILDIDMQGVKSVKQTDLNARFLFVAP 127
I + + +E+ ++ G+ YGT++++V+ V GK C++D++ Q ++ V+ +L +F+ P
Sbjct: 488 IYSHRMLEYGEYKGHLYGTSVDAVQTVLVEGKICVMDLEPQDIQGVRTHELKPYVIFIKP 547
Query: 128 PSVEVLKERLTGRGTET---------PESLEKRLNAAIAELEYAETGAHDLTVVNDDLDA 178
++ +K+ T E L++ N A +E D +VND L
Sbjct: 548 SNMRCMKQSRKNAKVITDYYVDMKFKDEDLQEMENLA-QRMETQFGQFFDHVIVNDSLHD 606
Query: 179 AYEKL 183
A +L
Sbjct: 607 ACAQL 611
>7292641 [F] KOG0708 Membrane-associated guanylate kinase MAGUK (contains
PDZ SH3 HOOK and GUK domains)
Length = 158
Score = 93.2 bits (230), Expect = 2e-19
Identities = 50/126 (39%), Positives = 74/126 (58%), Gaps = 4/126 (3%)
Query: 7 SRPIVISGPSGTGKSTLLKKLFAEYPTSFGFSVSSTTRQPRNGEVNGKDYNFVTV-DEFK 65
+RP++I GP K + L +EYP FG V TTR R EV+G+DY+FV+ ++ +
Sbjct: 33 TRPVIILGPL---KDRINDDLISEYPDKFGSCVPHTTRPKREYEVDGRDYHFVSSREQME 89
Query: 66 SMIDNKKFIEWAQFSGNYYGTTIESVKEVTNSGKTCILDIDMQGVKSVKQTDLNARFLFV 125
I N FIE Q++ N YGT++ SV+EV GK CILD+ +K ++ L +F+
Sbjct: 90 RDIQNHLFIEAGQYNDNLYGTSVASVREVAEKGKHCILDVSGNAIKRLQVAQLYPVAVFI 149
Query: 126 APPSVE 131
P SV+
Sbjct: 150 KPKSVD 155
>7298713 [T] KOG0609 Calcium/calmodulin-dependent serine protein
kinase/membrane-associated guanylate kinase
Length = 576
Score = 92.0 bits (227), Expect = 5e-19
Identities = 59/182 (32%), Positives = 93/182 (50%), Gaps = 7/182 (3%)
Query: 8 RPIVISGPSGTGKSTLLKKLFAEYPTSFGFSVSSTTRQPRNGEVNGKDYNFVTVDEFKSM 67
+ +V+ G SG G+ TL +L FG + T+R R E NG Y F+ +E +
Sbjct: 347 KTLVLIGVSGVGRRTLKNRLINSDVDKFGAVIPHTSRPKRALEENGSSYWFMDREEMEEA 406
Query: 68 IDNKKFIEWAQFSGNYYGTTIESVKEVTNSGKTCILDIDMQGVKSVKQT-DLNARFLFVA 126
+ N +F+E+ + +GN YGT ++S+K+V NSG+ CILD +K + + +L +FVA
Sbjct: 407 VRNNEFLEYGEHNGNLYGTHLQSIKDVINSGRMCILDCAPNALKILHNSQELMPFVIFVA 466
Query: 127 PPSVEVLK-----ERLTGRGTETPESLEKRLNAAIAELEYAETGA-HDLTVVNDDLDAAY 180
P +E LK R TG +L L+ + T A +D + +DDL A
Sbjct: 467 APGMEQLKTIYADRRATGSNRNLSATLVALLDLCLNTQTLLNTFAFYDFSEQDDDLVATV 526
Query: 181 EK 182
E+
Sbjct: 527 EE 528
>CE06728 [T] KOG0609 Calcium/calmodulin-dependent serine protein
kinase/membrane-associated guanylate kinase
Length = 668
Score = 91.7 bits (226), Expect = 6e-19
Identities = 51/183 (27%), Positives = 91/183 (48%), Gaps = 1/183 (0%)
Query: 8 RPIVISGPSGTGKSTLLKKLFAEYPTSFGFSVSSTTRQPRNGEVNGKDYNFVTVDEFKSM 67
RPIV+ G G G L +L + V T+R P+ GE NG Y+FV+ +F
Sbjct: 471 RPIVLCGAEGVGCLKLRDRLLESDRITLACPVPYTSRTPKEGEFNGVHYHFVSKQKFHED 530
Query: 68 IDNKKFIEWAQFSGNYYGTTIESVKEVTNSGKTCILDIDMQGVKSVKQTDLNARFLFVAP 127
+ KF+E+ ++ +YGT + V V GKTC++ + + + +++ D+ +F+A
Sbjct: 531 AKSGKFVEFGEYQKFWYGTAKKDVVNVIERGKTCVMTLKAESLGAIRSPDIQPYIIFIAA 590
Query: 128 PSVEVLKERLTGRGTETPESLE-KRLNAAIAELEYAETGAHDLTVVNDDLDAAYEKLKQF 186
PS+ +L+ + GT + E K + +E D +VN D + ++ +LKQ
Sbjct: 591 PSLYILRRQREVEGTFGVKDDELKAILTQSKSIEQKYGHLFDGIIVNIDFEKSFRELKQI 650
Query: 187 IFE 189
+ +
Sbjct: 651 LMK 653
>Hs4502567_2 [T] KOG0609 Calcium/calmodulin-dependent serine protein
kinase/membrane-associated guanylate kinase
Length = 561
Score = 91.7 bits (226), Expect = 6e-19
Identities = 48/180 (26%), Positives = 91/180 (49%), Gaps = 9/180 (5%)
Query: 8 RPIVISGPSGTGKSTLLKKLFAEYPTSFGFSVSSTTRQPRNGEVNGKDYNFVTVDEFKSM 67
+ +V+ G G G+ + L ++P F + + TTR P+ E NGK+Y FV+ D+
Sbjct: 375 KTLVLLGAHGVGRRHIKNTLITKHPDRFAYPIPHTTRPPKRDEENGKNYYFVSHDQMMQD 434
Query: 68 IDNKKFIEWAQFSGNYYGTTIESVKEVTNSGKTCILDIDMQGVKSVKQTDLNARFLFVAP 127
I N +++E+ YGT +E+++++ G ILD++ Q +K ++ + +F+A
Sbjct: 435 ISNNEYLEYGSHEDAMYGTKLETIRKIHEQGLIAILDVEPQALKVLRTAEFAPFVVFIAA 494
Query: 128 PSVEVLKERLTGRGTETPESLEKRLNAAIAELEYAETGAHDLTVVNDDLDAAYEKLKQFI 187
P++ G ESL+ RL L+ DLT++N+++D L++ +
Sbjct: 495 PTIT--------PGLNEDESLQ-RLQKESDILQRTYAHYFDLTIINNEIDETIRHLEEAV 545
>HsM4505239 [T] KOG0609 Calcium/calmodulin-dependent serine protein
kinase/membrane-associated guanylate kinase
Length = 585
Score = 90.9 bits (224), Expect = 1e-18
Identities = 51/185 (27%), Positives = 94/185 (50%), Gaps = 4/185 (2%)
Query: 4 GRMSRPIVISGPSGTGKSTLLKKLFAEYPTSFGFSVSSTTRQPRNGEVNGKDYNFVTVDE 63
G R +V+ G G L +K+ AE P FG +V TTR ++ E G +Y+FV+
Sbjct: 382 GERPRLVVLIGSLGARLHELKQKVVAENPQHFGVAVPHTTRPRKSHEKEGVEYHFVSKQA 441
Query: 64 FKSMIDNKKFIEWAQFSGNYYGTTIESVKEVTNSGKTCILDIDMQGVKSVKQTDLNARFL 123
F++ + + KF+E ++ N YGT++E+++ V K C++D++ + +K ++ ++ +
Sbjct: 442 FEADLHHNKFLEHGEYKENLYGTSLEAIQAVMAKNKVCLVDVEPEALKQLRTSEFKPYII 501
Query: 124 FVAPPSVEVLKERLTGRGTETP----ESLEKRLNAAIAELEYAETGAHDLTVVNDDLDAA 179
FV P E K E + ++ + A+ A ++ D +V +DL A
Sbjct: 502 FVKPAIQEKRKTPPMSPACEDTAAPFDEQQQEMAASAAFIDRHYGHLVDAVLVKEDLQGA 561
Query: 180 YEKLK 184
Y +LK
Sbjct: 562 YSQLK 566
>Hs21536464 [T] KOG0609 Calcium/calmodulin-dependent serine protein
kinase/membrane-associated guanylate kinase
Length = 585
Score = 90.9 bits (224), Expect = 1e-18
Identities = 51/185 (27%), Positives = 94/185 (50%), Gaps = 4/185 (2%)
Query: 4 GRMSRPIVISGPSGTGKSTLLKKLFAEYPTSFGFSVSSTTRQPRNGEVNGKDYNFVTVDE 63
G R +V+ G G L +K+ AE P FG +V TTR ++ E G +Y+FV+
Sbjct: 382 GERPRLVVLIGSLGARLHELKQKVVAENPQHFGVAVPHTTRPRKSHEKEGVEYHFVSKQA 441
Query: 64 FKSMIDNKKFIEWAQFSGNYYGTTIESVKEVTNSGKTCILDIDMQGVKSVKQTDLNARFL 123
F++ + + KF+E ++ N YGT++E+++ V K C++D++ + +K ++ ++ +
Sbjct: 442 FEADLHHNKFLEHGEYKENLYGTSLEAIQAVMAKNKVCLVDVEPEALKQLRTSEFKPYII 501
Query: 124 FVAPPSVEVLKERLTGRGTETP----ESLEKRLNAAIAELEYAETGAHDLTVVNDDLDAA 179
FV P E K E + ++ + A+ A ++ D +V +DL A
Sbjct: 502 FVKPAIQEKRKTPPMSPACEDTAAPFDEQQQEMAASAAFIDRHYGHLVDAVLVKEDLQGA 561
Query: 180 YEKLK 184
Y +LK
Sbjct: 562 YSQLK 566
>CE26970 [F] KOG0708 Membrane-associated guanylate kinase MAGUK (contains
PDZ SH3 HOOK and GUK domains)
Length = 1064
Score = 87.8 bits (216), Expect = 9e-18
Identities = 46/129 (35%), Positives = 71/129 (54%), Gaps = 4/129 (3%)
Query: 8 RPIVISGPSGTGKSTLLKKLFAEYPTSFGFSVSSTTRQPRNGEVNGKDYNFVTVDEFKSM 67
RP++I G K + +L P+ F V T+R PR GEVNG+DY FV +
Sbjct: 867 RPVIILGAL---KDRINDELVNRDPSKFSSCVPHTSRPPREGEVNGRDYYFVNKHNMEED 923
Query: 68 IDNKKFIEWAQFSGNYYGTTIESVKEVTNSGKTCILDIDMQGVKSVK-QTDLNARFLFVA 126
+ N FIE QF N YGT+I+SV++V N G+ CILD+ ++ ++ ++ +F+
Sbjct: 924 VKNNLFIEAGQFQNNLYGTSIQSVRDVANQGRHCILDVSGNAIRRLQSNANIQPISIFIK 983
Query: 127 PPSVEVLKE 135
P S + + E
Sbjct: 984 PSSAQQILE 992
>7300776 [T] KOG0609 Calcium/calmodulin-dependent serine protein
kinase/membrane-associated guanylate kinase
Length = 461
Score = 83.2 bits (204), Expect = 2e-16
Identities = 48/180 (26%), Positives = 88/180 (48%), Gaps = 9/180 (5%)
Query: 8 RPIVISGPSGTGKSTLLKKLFAEYPTSFGFSVSSTTRQPRNGEVNGKDYNFVTVDEFKSM 67
+ +V+ G G G+ + L ++YP + + + TTR + E NG+ Y FV+ DE +
Sbjct: 275 KTLVLLGAHGVGRRHIKNTLISKYPDKYAYPIPHTTRPAKPEEENGRSYYFVSHDEMMAD 334
Query: 68 IDNKKFIEWAQFSGNYYGTTIESVKEVTNSGKTCILDIDMQGVKSVKQTDLNARFLFVAP 127
I +++E+ YGT +++++ + GK ILD++ Q +K ++ + +F+A
Sbjct: 335 IGANEYLEYGTHEDAMYGTKLDTIRRIHTEGKMAILDVEPQALKILRTAEFTPYVVFIAA 394
Query: 128 PSVEVLKERLTGRGTETPESLEKRLNAAIAELEYAETGAHDLTVVNDDLDAAYEKLKQFI 187
PS++ + + SLE RL L DLT+VN+D+ L+ I
Sbjct: 395 PSLQNI--------ADYDGSLE-RLAKESEMLRQLYGHFFDLTIVNNDISETIATLETAI 445
>CE08914 [T] KOG0609 Calcium/calmodulin-dependent serine protein
kinase/membrane-associated guanylate kinase
Length = 506
Score = 77.4 bits (189), Expect = 1e-14
Identities = 41/133 (30%), Positives = 62/133 (45%)
Query: 8 RPIVISGPSGTGKSTLLKKLFAEYPTSFGFSVSSTTRQPRNGEVNGKDYNFVTVDEFKSM 67
R +V+ G GTG+ + L P F V T+R R GEV G++Y FV +E
Sbjct: 284 RTLVLLGAVGTGRRDIKSMLLRLAPHYFSTIVPLTSRAQRPGEVEGREYQFVRKEEIYQK 343
Query: 68 IDNKKFIEWAQFSGNYYGTTIESVKEVTNSGKTCILDIDMQGVKSVKQTDLNARFLFVAP 127
I +EW + YGT+ +SV+ SG+ C+LD Q V + + + V P
Sbjct: 344 IREGGMVEWGELDSQLYGTSADSVRNEIRSGRMCVLDAAPQSVNYLYNAEFMPFVVHVVP 403
Query: 128 PSVEVLKERLTGR 140
P +E + G+
Sbjct: 404 PPIEEFTQLEAGK 416
>Hs21389483_2 [F] KOG0707 Guanylate kinase
Length = 385
Score = 75.1 bits (183), Expect = 6e-14
Identities = 44/157 (28%), Positives = 79/157 (50%), Gaps = 2/157 (1%)
Query: 35 FGFSVSSTTRQPRNGEVNGKDYNFVTVDEFKSMIDNKKFIEWAQFSGNYYGTTIESVKEV 94
F + TTR P GE + DY+F++ D F M++ KFI + + YG ++V+ +
Sbjct: 2 FRYGACHTTRPPYFGEGDRVDYHFISQDVFDEMVNMGKFILTFSYGNHKYGLNRDTVEGI 61
Query: 95 TNSGKTCILDIDMQGVKSVKQTDLNARFLFVAPPSVEVLKERLTGRGTETPESLEKRLNA 154
G + ++++GV+S+K + R++ V P + E + L +G + +E ++
Sbjct: 62 ARDGLASCIHMEIEGVRSLKYSYFEPRYILVVPMNKEKYEGYLRRKGLFSRAEIEFAVSR 121
Query: 155 AIAELEYAET--GAHDLTVVNDDLDAAYEKLKQFIFE 189
++ + G D + DDLD AY+KL Q I E
Sbjct: 122 VDLYIKINQNFPGYFDEVINADDLDVAYQKLSQLIRE 158
>CE29125 [T] KOG0609 Calcium/calmodulin-dependent serine protein
kinase/membrane-associated guanylate kinase
Length = 567
Score = 73.6 bits (179), Expect = 2e-13
Identities = 51/212 (24%), Positives = 96/212 (45%), Gaps = 26/212 (12%)
Query: 8 RPIVISGPSGTGKSTLLKKLFAEYPTSFGFSVSSTTRQPRNGEVNGKDYNFVTVDEFKSM 67
R +V+ G G G++ + ++ F + F ++ T+R R E +G +Y F + E + M
Sbjct: 344 RVVVLLGAPGVGRNEIRRQFFKVFADRFTNAIPHTSRPQRPNESDGVNYYFTSRSEMERM 403
Query: 68 IDNKKFIEWAQFSGNYYGTTIESVKEVTNSGKTCILDIDMQGVKSVKQTDLNARFLFVAP 127
I+ K+ +E+ +F N YGT ++SV++ + G T +L +++++ + +FV P
Sbjct: 404 IERKEMLEYGEFRDNLYGTALKSVRKASEKG-TVLLTPHPLAIENIRTWEFAPIVIFVQP 462
Query: 128 PSV-------EVLKERLTGRGTETPESLEKRLNAAI------------------AELEYA 162
P EV + + T + S + AA A++E
Sbjct: 463 PEFGEFKHTREVYRSQTTRSHSAASSSNISQNTAATSAARAFSDVEIRQIIDNSAQMEQK 522
Query: 163 ETGAHDLTVVNDDLDAAYEKLKQFIFEEENKS 194
G D + N DLD +L I++ E+K+
Sbjct: 523 YRGYCDAIIRNVDLDTTMNELTGLIYQLESKA 554
>Hs17433806_1 [F] KOG0707 Guanylate kinase
Length = 201
Score = 55.8 bits (133), Expect = 4e-08
Identities = 22/49 (44%), Positives = 36/49 (72%)
Query: 38 SVSSTTRQPRNGEVNGKDYNFVTVDEFKSMIDNKKFIEWAQFSGNYYGT 86
++ TTR PR+GEV G DYNF++V++FK++ ++ +E + GN+YGT
Sbjct: 142 TIPCTTRAPRDGEVPGVDYNFISVEQFKALEESGALLESGTYDGNFYGT 190
>Hs9257195 [R] KOG3209 WW domain-containing protein
Length = 1256
Score = 55.1 bits (131), Expect = 6e-08
Identities = 30/67 (44%), Positives = 37/67 (54%), Gaps = 2/67 (2%)
Query: 38 SVSSTTRQPRNGEVNGKDYNFVTVDEFKSMIDNKKFIEWAQFSGNYYGTTIESVKEVTNS 97
+V TTR PR GEV G DYNF+TV EF + + +E + GNYYGT + V S
Sbjct: 141 AVPCTTRSPREGEVPGVDYNFLTVKEFLDLEQSGTLLEVGTYEGNYYGTPKPPSQPV--S 198
Query: 98 GKTCILD 104
GK D
Sbjct: 199 GKVITTD 205
>CE06035 [F] KOG0707 Guanylate kinase
Length = 288
Score = 48.1 bits (113), Expect = 8e-06
Identities = 20/47 (42%), Positives = 31/47 (65%)
Query: 38 SVSSTTRQPRNGEVNGKDYNFVTVDEFKSMIDNKKFIEWAQFSGNYY 84
+V TTR PR GEV+G+ Y FV+VD+F ++D+ +E + GN +
Sbjct: 231 TVPYTTRPPREGEVDGEHYRFVSVDDFNKLLDSGDLLENGTYQGNLF 277
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.313 0.132 0.367
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,782,346
Number of Sequences: 60738
Number of extensions: 480176
Number of successful extensions: 2400
Number of sequences better than 1.0e-05: 40
Number of HSP's better than 0.0 without gapping: 40
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 2334
Number of HSP's gapped (non-prelim): 40
length of query: 197
length of database: 30,389,216
effective HSP length: 101
effective length of query: 96
effective length of database: 24,254,678
effective search space: 2328449088
effective search space used: 2328449088
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)