ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactII1012 good T KOG3572 Signal transduction mechanisms Uncharacterized conserved protein, contains DEP domain
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactII1012 356871 352198 -1558
(1558 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YJR138w [T] KOG3572 Uncharacterized conserved protein contains D... 1395 0.0
SPBC26H8.04c [T] KOG3572 Uncharacterized conserved protein conta... 305 3e-82
Hs7662222 [T] KOG3572 Uncharacterized conserved protein contains... 181 1e-44
7292092_1 [T] KOG3572 Uncharacterized conserved protein contains... 180 2e-44
CE16370 [T] KOG3572 Uncharacterized conserved protein contains D... 135 5e-31
Hs5901914 [T] KOG2378 cAMP-regulated guanine nucleotide exchange... 59 5e-08
CE28076 [R] KOG3571 Dishevelled 3 and related proteins 55 7e-07
CE25100 [R] KOG3571 Dishevelled 3 and related proteins 55 7e-07
CE02318 [R] KOG3571 Dishevelled 3 and related proteins 55 7e-07
>YJR138w [T] KOG3572 Uncharacterized conserved protein contains DEP domain
Length = 1584
Score = 1395 bits (3611), Expect = 0.0
Identities = 724/1569 (46%), Positives = 1008/1569 (64%), Gaps = 84/1569 (5%)
Query: 52 TSGTNVTIRNNTLSIGVSSQMQGSAFNGPRMQLSTNGLKNTQSKALQAQSQDGCQDSKNI 111
T T+ T N++S+ + + GS N R + G + S +++ + N
Sbjct: 20 TPRTSNTTHANSISLSSGNLIVGSNRN-LRQKKEQFGSQQRASGRKLISNKENDDNVNNG 78
Query: 112 ADNDSDAEARTAK--------RSLELELAFHEARFSNEQVMVDISSIKGAKEGDLAELKT 163
DN+ D R + ++ + EL +HE+RFS VM+++ K GDL ELKT
Sbjct: 79 GDNNYDNGERVHRHHIPGLKIKAYQAELGYHESRFSENLVMLNLVEFPDIKPGDLVELKT 138
Query: 164 YRTSPGSK--DKKLYFIVKDFDTETRRRLKSFQISVLSGQLQQVLDLPIRSKVWVKLKEK 221
Y +P + DKK+YFI KDFD ET+RR K+ +S+LSGQLQ +LDLP RS++W+KLK
Sbjct: 139 YHKNPSASNGDKKIYFIAKDFDGETKRRAKTSNVSILSGQLQTLLDLPSRSRIWIKLKPN 198
Query: 222 K-QLAVDLVELHVKDSYVNRGDMWKFSTQLHDSCVFLGQRVGLIETVRATVKGIYINGKK 280
K L D+VE ++KD +NRGDMW S++L D+CVF+ QR+ ++++R T+KGIY NGKK
Sbjct: 199 KFDLQADVVEFNIKDCLLNRGDMWVLSSKLVDTCVFMDQRLAFLDSIRGTIKGIYRNGKK 258
Query: 281 IFSGYIDENTKIVFRSESAKLLFMIQITDEMWHFEENGEETFHKVVNSLFPKIFRKWKNI 340
I SGYI E T+I+FRSESA+L+F+IQITDEMW+FEE GE+ F K+VNS FPKIF+KWK++
Sbjct: 259 IVSGYIGEQTRIIFRSESARLIFLIQITDEMWNFEETGEQLFQKMVNSFFPKIFKKWKDV 318
Query: 341 GTHHSISIMFCASIDRSDSSFNDVTSGERLKNTDDYYRAVVDQVNIVHWVEIMKTLRKEF 400
THH+I+I F S+D SD+SF D+T GE LKN+ DY+R VVDQV+I+HWV+IM+TLR+EF
Sbjct: 319 DTHHTITIAFAISMDLSDTSFKDLTPGESLKNSQDYFRIVVDQVSIIHWVDIMETLREEF 378
Query: 401 IRIAQDLRNVKLNENVSVIKGSLPSVIKSNLLETINLATTLVTDPFKQNDLRHTTTHAII 460
+ I +DL N + ++ SV G VIKSN LE +N ATT++TDPFKQ DLRHTTTH +I
Sbjct: 379 MEIRKDLLNKQTDKGYSVANGRFSPVIKSNFLELVNFATTILTDPFKQLDLRHTTTHVMI 438
Query: 461 VTAGSGLYDVDYDLLKITTQKLMSLEITMDLICLSRPPLHIVPLLRYRDYKDQLHYCTPT 520
++ GSGL+DVDY LL++T +KL+SLE+TMDLICLS+ PLHIVPL RYRD++++LH+C P
Sbjct: 439 ISPGSGLFDVDYSLLRLTGKKLLSLEMTMDLICLSKAPLHIVPLFRYRDFENKLHHCVPL 498
Query: 521 WLSISFWND-SSRANVEWRPRCKIYNVLMMGLTETELKEEIALQSIKINDKCNSVSDFME 579
WLS+ FWND ++N EW PRCKIY++ MMG+TE EL E+ ++ +++N K S+S+FM
Sbjct: 499 WLSVFFWNDHDKKSNSEWTPRCKIYDLQMMGITENELIREVDVEYLQLNKKVKSLSEFMN 558
Query: 580 SYDSAAFEVQ------SGPYSMHMDAALAAEFRSSKESKNDWNRRTVSKSKGNTNHIDTI 633
YD AFEV+ + S +++ F + K T + + GNT I
Sbjct: 559 DYDKNAFEVKILCAGSNTKQSKKLNSKFDTVFENDVVVKARKIPATATTTHGNTKFI--- 615
Query: 634 TWMKPKSTNAVLQPAFKEKVFAQLS-----------------------SSPNSNLPRTE- 669
W PK ++ K V LS +S N NL +
Sbjct: 616 -WRGPKVALPAIKDIQKPNVIPDLSIKTIEASFYDDCNTTNDKISTPTTSNNDNLEMNDS 674
Query: 670 -FEYKNQMTATNSLALNTLKRLSHANS--GVTQKIISKLFPDLAIKKSQ----SSLRQKA 722
++ SLAL++LK LS NS TQ++I+K ++ K++ + LR
Sbjct: 675 LVSVRSADNQNTSLALDSLKGLSKRNSLKDFTQRVITKFISNIDTSKNKKIKSTLLRDDV 734
Query: 723 NIQP----TXXXXXXXXXXXXXXQYKRSPNPKLLHKQKQLF----------DDNKKEASC 768
+ P T Q K + ++ K+ L N+ +
Sbjct: 735 DNSPLGSNTPLPSSESKISGLKLQQKGLADENVISKRGNLIIKKNLSIFGLPSNEIMSGS 794
Query: 769 GTSILSSQ----SSGNQRVQDKNFLLSE--TSLKTSXXXXXXXXGIK---GDSWIEIENP 819
+S L S SS + DK ++E S +K ++W++I++P
Sbjct: 795 PSSYLGSSHTRTSSKLSNMSDKAAFITEGQKSKHDDSNTYSLTQQLKHRISETWVDIKSP 854
Query: 820 SVPVDAELASYLIPNRWKDVFPKYVAKKYTKWRSFTTPAELPLTTSMFPTPFDFEHQFSL 879
S+PV +E A+ L+P RWKDV+PKYVA+KY+KWRSFTTPAELP+T S FP+ DF+ F
Sbjct: 855 SIPVSSEFANELLPIRWKDVWPKYVARKYSKWRSFTTPAELPITISDFPSKDDFDRNFIF 914
Query: 880 RNHTVSLNIEQEGYQQSVFDLLQNMIYVRLLAGFQFCLGKNVTRVEKARDKDTDGSRITH 939
RNH+V+LN +QE Y Q+ DLL++MIY+RLL GFQ C+G+ V ++E +R+ + +
Sbjct: 915 RNHSVTLNTDQEQYNQTYKDLLRDMIYMRLLTGFQICVGRQVEKIELSRESGESETVVNK 974
Query: 940 LINKENYRDVSIYLRIDNEIHRIVCFDE-TIDVQKYIKHDDSKLLQSFAKYTPYVKTRYE 998
++ +YL ID+EIHRI C IDV++Y++ D++ L Y P VKTRYE
Sbjct: 975 YLDFNQNDAFKLYLMIDSEIHRITCSSSGIIDVERYLRKDEANLFDQVPSYIPLVKTRYE 1034
Query: 999 VEYRELDLDPVKTRRESYNWNQIDQVLAGFNDTIMDPATQKRFRCKFVILPAEIPPNTFQ 1058
+R+ +DP+ +RES NWNQIDQVLAG+ D ++D FR K+V+LP +IPPNT+
Sbjct: 1035 SSFRDAMIDPLHVKRESLNWNQIDQVLAGYGDNLIDRKWHG-FRAKYVVLPTDIPPNTYS 1093
Query: 1059 STINGRKETLTAEEIRLEGXXXXXXXXXXXXXXTEHEKKDKRSHKEEILPEVLFYTGYLF 1118
ING+ ETL EEIR+EG TE EKK +++ +EEI PEV+FYTG L+
Sbjct: 1094 MVINGKSETLNPEEIRVEGLRRLIGSITRSRLRTEKEKKGRKTKREEIQPEVMFYTGPLY 1153
Query: 1119 DFIEEHNDFLKNSGAAVKNSIFMEDAETLSKDADLTKIAYELQHGVYQIKLVNRKWHWKR 1178
+FI E L++S K+SIF+ D L+++ +L+K+AY++Q G +I LVNRKWHWK+
Sbjct: 1154 NFINEQQTSLESSAINFKDSIFVNDNNLLNRNVELSKLAYQIQRGEDRITLVNRKWHWKK 1213
Query: 1179 HENCFIGLELVNWLIEHFSDVHTREDAVVYGQELMNKGLFHHVESRHGFLDGHYFYQLNP 1238
HE CF+G E+VNWLI +FSD+ TREDA+ YGQ++M +GLF HV ++H FLDGHYFYQ +P
Sbjct: 1214 HEKCFVGSEMVNWLIRNFSDIDTREDAIKYGQKVMKEGLFVHVLNKHNFLDGHYFYQFSP 1273
Query: 1239 EFTTENKTLYKTSTKHSNES---HLMRKISTSNKSESAKSIDPTISVESNQQSEDQITKP 1295
E+ + L KT++ S S ++RK ST + ++ + + V + S +
Sbjct: 1274 EYVMDTNKLEKTNSHRSTLSDPKQMLRKASTGSSNDPSAMTPFSSVVPAISASNASVADA 1333
Query: 1296 EEHSITVL-LSNAVTVDLDPSRKSYKLETCIAHYDRVHNPDHCFHIRLEWLTATPKLIDD 1354
+E S +L LSN++ +D+DP+ KS K E+C HYDRVHNPDHCFHIRLEWLT TPKLIDD
Sbjct: 1334 KEPSRPILMLSNSLVIDVDPAGKSSKQESCTVHYDRVHNPDHCFHIRLEWLTTTPKLIDD 1393
Query: 1355 LISNWSRLAERYGLKLVEIPWDELCNIPKINPFHSFMNIKLAINPWQDLEFKDETIFREQ 1414
L+ NWSRL ERYGLK++EIPW+ELC IP +NPFHSF+ IKLAINPW+D EFKD +F +
Sbjct: 1394 LVGNWSRLCERYGLKMIEIPWEELCTIPSVNPFHSFVEIKLAINPWEDPEFKDRELFAKS 1453
Query: 1415 KFFYHIYLLEKSGFLLDNRASKFFQSEKTNSYQIIYSWGKPMFKYAQYIHYTGSCMAEIR 1474
KF+YH+YLL+ SGFLLDNRASKF Q++ + I+YSWGKP FKY QYIH+TG+ +AE+R
Sbjct: 1454 KFYYHVYLLKASGFLLDNRASKFLQNQDI-EFDIMYSWGKPQFKYVQYIHHTGAYVAELR 1512
Query: 1475 ESGDFFLAPNNLHISRMNTGNIGSKASSHLKFTSDAQKIMLNFRKTCENYESLRDIFLEA 1534
E+G FLAPNN++ISR+N GNI K S + DAQK++LNF+ TC +Y+ LR IFL+A
Sbjct: 1513 ENGCLFLAPNNIYISRVNPGNIIGKIHSASSSSLDAQKVILNFKSTCLDYQKLRSIFLDA 1572
Query: 1535 KEKHIDNRV 1543
KE I ++
Sbjct: 1573 KEMWITGKI 1581
>SPBC26H8.04c [T] KOG3572 Uncharacterized conserved protein contains DEP domain
Length = 1496
Score = 305 bits (782), Expect = 3e-82
Identities = 215/739 (29%), Positives = 351/739 (47%), Gaps = 57/739 (7%)
Query: 813 WIEIENPSVPVDAELASYLIPNRWKDVFPKYVAKKYTKWRSFTTPAELPLTTSMFPTPFD 872
W I+NP + + + RW+ ++ K + W S TP LPLT S FP+ +
Sbjct: 761 WKIIQNPFKLKETTADNDPVSLRWEHLYMKVQDVRKFNWLSMCTPGALPLTFSYFPSEEE 820
Query: 873 FEHQFSLRNHTVSLNIEQEGYQQSVFDLLQNMIYVRLLAGFQFCLGKNVTRVEKARDKDT 932
+F +T ++ I+ E Q + +LL MI RL G+Q + K
Sbjct: 821 LNDKFE--EYTYTIGIDPEFTQMNQQELLAEMICQRLSRGYQIVVNPAAAVSYSGNPKAN 878
Query: 933 DGSRITHLINKENYR---------DVSIYLRIDNEIHRIVC--FDETIDVQKYIKHDDSK 981
IT N + D D++ HR+ C I+V++Y+K
Sbjct: 879 KAGTITDFSRSVNNQRNGHLTVGSDAVCLSLGDSQFHRLSCDSVGYNIEVKRYVKKVSG- 937
Query: 982 LLQSFAKYTPYVKTRYEVEYRELDLDPVKTRRESYNWNQIDQVLAGFNDTIMDPATQKRF 1041
Q +Y ++ E +Y + ++ +YNWN +DQ++ GF + P + K +
Sbjct: 938 --QGKMRYDYNFWSKNECKYVKSNITFSANDSANYNWNYVDQLICGFETYL--PDSVKYW 993
Query: 1042 RCKFVILP-AEIPPNTFQS-TINGRKETLTAEEIRLEGXXXXXXXXXXXXXXTEHEKKDK 1099
R +FV+LP + + FQ + + L+ EE R+EG ++ +K
Sbjct: 994 RARFVLLPMSTTSTHVFQKYQLLDHADALSDEEFRVEGIYKLSELLYKGKIDPMNDSNNK 1053
Query: 1100 RSHKEEI-LPEVLFYTGYLFDFIEEHNDFLKNSGAAVKNSIFMEDAETLSKDADLTKIAY 1158
+ L + F T + +I + L+ + + S+FM + + L ADL IA
Sbjct: 1054 TPNTSPAELLGIKFTTLPMAQYIHSELEALRLDSSRNEQSLFMPN-KRLDCSADLHTIAK 1112
Query: 1159 ELQHGVYQIKLVNRKWHWKRHENCFIGLELVNWLIEHFSDVHTREDAVVYGQELMNKGLF 1218
E+Q G K+ + WH++ +ENCF+G E V+WL F ++TRE+A+ YG +L++ GLF
Sbjct: 1113 EIQ-GPGGPKIDDITWHYRIYENCFLGSEFVSWLANTFIGINTREEALKYGNKLLSLGLF 1171
Query: 1219 HHVESRHGFLDGHYFYQLNPEFTTENKTLYKTSTKHSNESHLMRKISTSNKSESAKSIDP 1278
H +H LDG+Y Y+++P+++ K + S RK K K +D
Sbjct: 1172 DHALKKHPLLDGYYVYRISPDYSI------KPVSNRPYRSWFSRK-----KDSGQKHLDN 1220
Query: 1279 TISVESNQQSEDQITKPEEHSITVLLSNAVTVDLDPSRKSYKLETCIAHYDRVHNPDHCF 1338
I IT+ E + LS + + D +K+ K ET HYD +HNP C+
Sbjct: 1221 KI-----------ITESEAGPSRLELSRRILFNADVEKKNGKSETVTVHYDLLHNPASCY 1269
Query: 1339 HIRLEWLTATPKLIDDLISNWSRLAERYGLKLVEIPWDELCNIPKINPFHSFMNIKLAIN 1398
HIR+EWL AT +I+ L+ +WSR+ ERYGLKLVE P E+ + ++NPF I LA++
Sbjct: 1270 HIRIEWLLATASVIEKLLQSWSRILERYGLKLVEAPIHEIAAVGELNPFDQVSIISLALD 1329
Query: 1399 PWQDLE----FKDETIFREQKFFYHIYLLEKSGFLLDNRASKFFQSEKTNSYQIIYSWGK 1454
P E D + K ++++ +LE F+LD A+ F S +YSWGK
Sbjct: 1330 PPPIPERAPLVNDPVNY--SKNWWNVKILEHFDFILDTEAASTF----PKSITAVYSWGK 1383
Query: 1455 PMFKYAQYIHYTGSCMAEIRESGDFFLAPNNLHISRMNTGNI--GSKASSHLKFTSDAQK 1512
P F+Y QYIH TG+ + +I + F PN LH S+++ + +K++ + A++
Sbjct: 1384 PNFRYVQYIHRTGTVLVQIDDDQRFLWLPNRLHNSKVSKLSFTKSNKSTLNPNLKETAEE 1443
Query: 1513 IMLNFRKTCENYESLRDIF 1531
+ FR+ C N + L +
Sbjct: 1444 LERKFREFCSNKDELDQFY 1462
Score = 214 bits (546), Expect = 7e-55
Identities = 130/428 (30%), Positives = 220/428 (51%), Gaps = 46/428 (10%)
Query: 126 SLELELAFHEARFSNEQVMVDISSIKGAKEGDLAELKTYR----------TSPGSKDKK- 174
++ L L HE+ +++ + AK GD+ E++ +S G K
Sbjct: 2 AITLNLWTHESSLFPNDAVLNYDLVPSAKPGDIFEIRAQNGDEIALQHNHSSTGKLHAKR 61
Query: 175 ----LYFIVKDFDTETRRRLKSFQISVLSGQLQQVLDLPIRSKVWVKL-KEKKQLAVDLV 229
+Y + + +RR + Q+SV+S + +L++ R V VK+ ++K L + V
Sbjct: 62 EKEPVYLMPSPLTDDLKRRHPNLQLSVVS-HISSLLNIKNREPVVVKICEDKTNLEAEHV 120
Query: 230 ELHVKDSYVNRGDMWKFSTQLHDSCVFLGQRVGLIETVRATVKGIYINGKKIFSGYIDEN 289
+ +D +++R DMWK +L CV+L QRV I V ++ I+ GKK S YI E
Sbjct: 121 VIFFRDQFISRSDMWKLFRELCGKCVYLKQRVSFIGDVPGEIRCIWRKGKKCHSAYISER 180
Query: 290 TKIVFRSESAKLLFMIQITDEMWHFEENGEETFHKVVNSLFPKIFRKWKNIGTHHSISIM 349
TK +FRSESA+ L IQ+++EMWHFEE+GE ++K ++ P +F W+++GTHH +SI+
Sbjct: 181 TKPIFRSESARFLIFIQMSEEMWHFEEDGELNYNKAIDGFLPDLFSFWRDLGTHHLVSII 240
Query: 350 FCASIDRSDSSFNDVTSGERLKNT-----------------------DDYYRAVVDQVNI 386
++ S V KN+ +D+++ VVD V+
Sbjct: 241 LFTRVEYSHHGPMCVWQPRSQKNSEKGSSIYPQNSFNASIDNEGGPYEDFFKVVVDNVSS 300
Query: 387 VHWVEIMKTLRKEFIRIAQD--LRNVKLNEN---VSVIKGSLPSVIKSNLLETINLATTL 441
W ++ L+ E + QD +R +K +EN + I G + + N LE IN+A
Sbjct: 301 RDWQPVLANLKLELAKFRQDVIVRKIK-DENGREIEYICGRMTGSQEGNFLEVINMAVFQ 359
Query: 442 VTDPFKQNDLRHTTTHAIIVTAGSGLYDVDYDLLKITTQKLMSLEITMDLICLSRPPLHI 501
+ DL T T IIVT G+GLY+V+ +L +T++ L++ + MD++ L + PL +
Sbjct: 360 FQSDYIDRDLSRTGTSIIIVTPGTGLYEVNEKMLHLTSKSLLNTVVGMDIVSLGKVPLFL 419
Query: 502 VPLLRYRD 509
P++RY++
Sbjct: 420 TPIVRYKN 427
>Hs7662222 [T] KOG3572 Uncharacterized conserved protein contains DEP domain
Length = 1572
Score = 181 bits (458), Expect = 1e-44
Identities = 127/501 (25%), Positives = 233/501 (46%), Gaps = 31/501 (6%)
Query: 130 ELAFHEARF--SNEQVMVDISSIKGAKEGDLAELKTYRTSPGSKDKKLYFIVKDFDTETR 187
+L H+ F S+++++V+ K GD+ E+ P + L VK + +
Sbjct: 8 KLVIHKKGFGGSDDELVVNPKVFPHIKLGDIVEI----AHPNDEYSPLLLQVKSLKEDLQ 63
Query: 188 RRLKSFQISVLSGQLQQVLDLPIRSKVWVKLKEKKQLAVDLVELHVKDSYVNRGDMWKFS 247
+ S +V QV L V+V + + K + +DLVEL KD Y+ RGDMW+
Sbjct: 64 KETISVDQTVT-----QVFRLRPYQDVYVNVVDPKDVTLDLVELTFKDQYIGRGDMWRLK 118
Query: 248 TQLHDSCVFLGQRVGLIETVRATVKGIYINGKKIFSGYIDENTKIVFRSESAKLLFMIQI 307
L +C ++ Q+V +RA +++ +K+ GYI E+T++VFRS SA + IQ+
Sbjct: 119 KSLVSTCAYITQKVEFAG-IRAQAGELWVKNEKVMCGYISEDTRVVFRSTSAMVYIFIQM 177
Query: 308 TDEMWHFEENGEETFHKVVNSLFPKIFRKWKNIGTHHSISIMF-------CASIDR-SDS 359
+ EMW F+ G+ F K VN +F KWK H ++++ S+D +
Sbjct: 178 SCEMWDFDIYGDLYFEKAVNGFLADLFTKWKEKNCSHEVTVVLFSRTFYDAKSVDEFPEI 237
Query: 360 SFNDVTSGERLKNTDDYYRAVVDQVNIVHWVEIMKTLRKEFIRIAQDLRNVKLNENVSVI 419
+ + + + +D+Y+ VV W ++ T++K FI+ V+L +
Sbjct: 238 NRASIRQDHKGRFYEDFYKVVVQNERREEWTSLLVTIKKLFIQYPV---LVRLEQAEGFP 294
Query: 420 KGSLPSVIKSNLLETINLATTLVTDPFKQNDLRHTTTHAIIVTAGSGLYDVDYDLLKITT 479
+G + + N LE INL+ + + + T ++++T G G+++VD L+ +T
Sbjct: 295 QGDNSTSAQGNYLEAINLSFNVFDKHYINRNFDRTGQMSVVITPGVGVFEVDRLLMILTK 354
Query: 480 QKLMSLEITMDLICLSRPPLHIVPLLRY------RDYKDQLHYCTPTWLSISFWNDSSRA 533
Q+++ I +DL+C+ PLH VPL + RD + Y P W++ SF+ S+
Sbjct: 355 QRMIDNGIGVDLVCMGEQPLHAVPLFKLHNRSAPRDSRLGDDYNIPHWINHSFYTSKSQL 414
Query: 534 NV-EWRPRCKIYNVLMMGLTETELKEEIALQSIKINDKCNSVSDFMESYDSAAFEVQSGP 592
+ PR K+ + + + +L S K ++ + ++YD+ F +
Sbjct: 415 FCNSFTPRIKLAG-KKPASEKAKNGRDTSLGSPKESENALPIQVDYDAYDAQVFRLPGPS 473
Query: 593 YSMHMDAALAAEFRSSKESKN 613
+ + + R S K+
Sbjct: 474 RAQCLTTCRSVRERESHSRKS 494
Score = 57.8 bits (138), Expect = 1e-07
Identities = 52/223 (23%), Positives = 94/223 (41%), Gaps = 12/223 (5%)
Query: 838 DVFPKYVAKKYTKWRSFTTPAELPLTTSMFPTPFDFEHQFS-----LRNHTVSLNIEQEG 892
D P + W+S TTPA LPLTT FP ++ ++ L +++G
Sbjct: 722 DPMPGFCCTVGVDWKSLTTPACLPLTTDYFPDRQGLQNDYTEGCYDLLPEADIDRRDEDG 781
Query: 893 YQQSVFDLLQNMIYVRLLAGFQFCLGKNVTRVEKARDKDTDGSRI--THLINKENYRDVS 950
Q + + + I RL+ G+Q + + A S + L+++ +
Sbjct: 782 VQMTAQQVFEEFICQRLMQGYQIIVQPKTQKPNPAVPPPLSSSPLYSRGLVSRNRPEEED 841
Query: 951 IY-LRIDNEIHRIVCFDETIDVQKYIKHDDSKLLQSFAKYTPYVKTRYEVEYRELDLDPV 1009
Y L + H++ D+ I V +Y+ + Q Y+ + + E+ ++
Sbjct: 842 QYWLSMGRTFHKVTLKDKMITVTRYLPKYPYESAQIHYTYS-LCPSHSDSEFVSCWVEFS 900
Query: 1010 KTRRESYNWNQIDQVL--AGFNDTIMDPATQKRFRCKFVILPA 1050
R E Y WN +DQ + AG D + + K +R +F++LPA
Sbjct: 901 HERLEEYKWNYLDQYICSAGSEDFSLIESL-KFWRTRFLLLPA 942
>7292092_1 [T] KOG3572 Uncharacterized conserved protein contains DEP domain
Length = 721
Score = 180 bits (456), Expect = 2e-44
Identities = 117/456 (25%), Positives = 218/456 (47%), Gaps = 37/456 (8%)
Query: 195 ISVLSGQLQQVLDLPIRSKVWVKLKEKKQLAVDLVELHVKDSYVNRGDMWKFSTQLHDSC 254
IS+ SG + + S V +++ + +A+D +E+ KD Y+ R +MW+ T L D+C
Sbjct: 44 ISIESG-IANAFKMRPYSNVVMRIVKPADVALDSIEITFKDQYMGRSEMWRLKTYLTDTC 102
Query: 255 VFLGQRVGLIET-VRATVKGIYINGKKIFSGYIDENTKIVFRSESAKLLFMIQITDEMWH 313
V++ +++ + +R V ++ G+++ SG I E+TKIVFRS ++ + +Q++ EMW
Sbjct: 103 VYVNKKIDYNDMQIRCQVYEMWSQGERVASGVITEDTKIVFRSSTSMVYLFLQMSSEMWD 162
Query: 314 FEENGEETFHKVVNSLFPKIFRKWKNIGTHHSISIMFCA-------SIDRSDSSFNDVTS 366
F+ +G+ F K VN ++F+KW+ + +H ++I+ + S+D D
Sbjct: 163 FDIHGDLYFEKAVNGFLTELFQKWRKLSCNHEVTIVLFSRTFYAAKSLDEFPEHMRDCLQ 222
Query: 367 GE-RLKNTDDYYRAVVDQVNIVHWVEIMKTLRKEFIRIAQDLRNVKLNENVSVIKGSLPS 425
+ + + +D+YR + W ++ LRK F + EN+ + + S
Sbjct: 223 QDYKGRFYEDFYRVAIQNERCDDWCTVLGQLRKLFTSYQATVLRYHERENMKIPPATNSS 282
Query: 426 VIKSNLLETINLATTLVTDPFKQNDLRHTTTHAIIVTAGSGLYDVDYDLLKITTQKLMSL 485
+ N LE +N++ + T ++++T G G++ VD +L IT Q+++
Sbjct: 283 ATQGNFLEVLNISLNTFEKHYLDRTFDRTGQLSVVITPGVGVFSVDRELTNITKQRIIDN 342
Query: 486 EITMDLICLSRPPLHIVPLLRYRDYKDQL----HYCTPTWLSISFWNDSSR-ANVEWRPR 540
+ DL+C+ PLH VPLL++ + L Y P W+++SF++ + + + PR
Sbjct: 343 GVGSDLVCVGEQPLHAVPLLKFHNKDTTLTSADDYSLPHWINLSFYSTNKKIVYSSFIPR 402
Query: 541 CK--IYNVLM-----MGLTETELKEEIALQSIKINDKCNSVSDFMESYDSAAFEVQSGPY 593
K ++ + +G E E E L + K NS+ D+ ++YD F+ P
Sbjct: 403 IKLPLFGSQLTLHDGVGDGEGEENERHFLSCNQSEYKHNSLFDY-DAYDEQIFQ----PL 457
Query: 594 SMHMDAALAAEFRSSKES----------KNDWNRRT 619
+L R+ K S NDW T
Sbjct: 458 PAQSTCSLQRVVRAKKTSVPSLETYAYRNNDWENLT 493
>CE16370 [T] KOG3572 Uncharacterized conserved protein contains DEP domain
Length = 1872
Score = 135 bits (340), Expect = 5e-31
Identities = 79/333 (23%), Positives = 163/333 (48%), Gaps = 15/333 (4%)
Query: 224 LAVDLVELHVKDSYVNRGDMWKFSTQLHDSCVFLGQRVGLIETVRATVKGIYINGKKIFS 283
+++D V+L ++ Y++R DM+++ + L ++ + + + + ++ G + S
Sbjct: 367 VSLDNVQLTFREQYMSRADMYRYRSCLIGRMTYVEEPKRYMN-INTRISDMWRKGSLVRS 425
Query: 284 GYIDENTKIVFRSESAKLLFMIQITDEMWHFEENGEETFHKVVNSLFPKIFRKWKNIGTH 343
GY+ + T++VFRS S+ +L IQ+ EM + G+ K + ++F KWK
Sbjct: 426 GYVTDKTRVVFRSSSSTVLIFIQMCSEMNQLDPQGDLYLEKCIKGFLTELFLKWKEQSCT 485
Query: 344 HSISIMFCA------SIDRSDSSFNDVTSGERLKNTDDYYRAVVDQVNIVHWVEI-MKTL 396
H +SI+ C+ +D + F R + D+YR + + W + +K +
Sbjct: 486 HYVSIILCSRWYAIGGVDDAAKRFMKGACDHRGRYYQDFYRLLFQNEHYEDWADKQLKEI 545
Query: 397 RKEFIRIAQDLRNVKLNENVSVIKGSLPSVIKSNLLETINLATTLVTDPFKQNDLRHTTT 456
+ + ++ KL E + ++ + + N L+ +N++ + T
Sbjct: 546 NVGCSKYSSQIQE-KLKEMLPQVQFEVSTAADGNFLQVVNMSMNSFSMYHSDRRFETTGQ 604
Query: 457 HAIIVTAGSGLYDVDYDLLKITTQKLMSLEITMDLICLSRPPLHIVPLLRYRDYKDQL-- 514
I VT G+G+ VD DL+ +T Q+++ + I++D++CL PLH VPL + Q+
Sbjct: 605 QIIFVTPGNGVLHVDRDLVSLTKQRVIDMGISLDMVCLGEQPLHAVPLFVFHPIVGQMDK 664
Query: 515 --HYCTPTWLSISFWNDSSRA--NVEWRPRCKI 543
Y P W++ S++ + R+ +V++RPR ++
Sbjct: 665 KCEYFIPHWMNYSYYQMARRSAISVQFRPRIQL 697
>Hs5901914 [T] KOG2378 cAMP-regulated guanine nucleotide exchange factor
Length = 1011
Score = 59.3 bits (142), Expect = 5e-08
Identities = 25/65 (38%), Positives = 40/65 (61%)
Query: 1171 NRKWHWKRHENCFIGLELVNWLIEHFSDVHTREDAVVYGQELMNKGLFHHVESRHGFLDG 1230
+RK+H K + C +G ELV+W+++ VH+R AV Q L+ G+ +HV+ H F D
Sbjct: 224 DRKYHLKTYRQCCVGTELVDWMMQQTPCVHSRTQAVGMWQVLLEDGVLNHVDQEHHFQDK 283
Query: 1231 HYFYQ 1235
+ FY+
Sbjct: 284 YLFYR 288
>CE28076 [R] KOG3571 Dishevelled 3 and related proteins
Length = 625
Score = 55.5 bits (132), Expect = 7e-07
Identities = 29/92 (31%), Positives = 47/92 (50%)
Query: 1142 EDAETLSKDADLTKIAYELQHGVYQIKLVNRKWHWKRHENCFIGLELVNWLIEHFSDVHT 1201
E E L++ D + + + + NRKW FIG +LV+WL++H +D+H
Sbjct: 365 EKIEQLTEMIDPIIVVRSMARPDSGLAVKNRKWLKILVPMSFIGRDLVDWLVDHMADIHN 424
Query: 1202 REDAVVYGQELMNKGLFHHVESRHGFLDGHYF 1233
R+ A +Y L+ GL HV S+ F + Y+
Sbjct: 425 RKKARIYAARLLAAGLIRHVVSKLTFTEKCYY 456
>CE25100 [R] KOG3571 Dishevelled 3 and related proteins
Length = 666
Score = 55.5 bits (132), Expect = 7e-07
Identities = 29/92 (31%), Positives = 47/92 (50%)
Query: 1142 EDAETLSKDADLTKIAYELQHGVYQIKLVNRKWHWKRHENCFIGLELVNWLIEHFSDVHT 1201
E E L++ D + + + + NRKW FIG +LV+WL++H +D+H
Sbjct: 406 EKIEQLTEMIDPIIVVRSMARPDSGLAVKNRKWLKILVPMSFIGRDLVDWLVDHMADIHN 465
Query: 1202 REDAVVYGQELMNKGLFHHVESRHGFLDGHYF 1233
R+ A +Y L+ GL HV S+ F + Y+
Sbjct: 466 RKKARIYAARLLAAGLIRHVVSKLTFTEKCYY 497
>CE02318 [R] KOG3571 Dishevelled 3 and related proteins
Length = 672
Score = 55.5 bits (132), Expect = 7e-07
Identities = 29/92 (31%), Positives = 47/92 (50%)
Query: 1142 EDAETLSKDADLTKIAYELQHGVYQIKLVNRKWHWKRHENCFIGLELVNWLIEHFSDVHT 1201
E E L++ D + + + + NRKW FIG +LV+WL++H +D+H
Sbjct: 406 EKIEQLTEMIDPIIVVRSMARPDSGLAVKNRKWLKILVPMSFIGRDLVDWLVDHMADIHN 465
Query: 1202 REDAVVYGQELMNKGLFHHVESRHGFLDGHYF 1233
R+ A +Y L+ GL HV S+ F + Y+
Sbjct: 466 RKKARIYAARLLAAGLIRHVVSKLTFTEKCYY 497
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.317 0.132 0.384
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 91,097,323
Number of Sequences: 60738
Number of extensions: 3911021
Number of successful extensions: 10975
Number of sequences better than 1.0e-05: 9
Number of HSP's better than 0.0 without gapping: 9
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 10929
Number of HSP's gapped (non-prelim): 21
length of query: 1558
length of database: 30,389,216
effective HSP length: 120
effective length of query: 1438
effective length of database: 23,100,656
effective search space: 33218743328
effective search space used: 33218743328
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)