ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactII1152 good OPR KOG2195 General function prediction only Transferrin receptor and related proteins containing the protease-associated (PA) domain
r_klactII1152 good OPR KOG2195 Inorganic ion transport and metabolism Transferrin receptor and related proteins containing the protease-associated (PA) domain
r_klactII1152 good OPR KOG2195 Posttranslational modification, protein turnover, chaperones Transferrin receptor and related proteins containing the protease-associated (PA) domain
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactII1152 407088 409412 775
(775 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YJR126c [OPR] KOG2195 Transferrin receptor and related proteins ... 641 0.0
At5g19740 [OPR] KOG2195 Transferrin receptor and related protein... 249 9e-66
Hs4758398 [OPR] KOG2195 Transferrin receptor and related protein... 236 8e-62
Hs4885505 [OPR] KOG2195 Transferrin receptor and related protein... 231 3e-60
Hs20480969 [OPR] KOG2195 Transferrin receptor and related protei... 228 3e-59
At3g54720 [OPR] KOG2195 Transferrin receptor and related protein... 209 1e-53
Hs4885507 [OPR] KOG2195 Transferrin receptor and related protein... 191 3e-48
CE12844 [OPR] KOG2195 Transferrin receptor and related proteins ... 188 2e-47
SPBC354.09c [OPR] KOG2195 Transferrin receptor and related prote... 173 1e-42
CE08584 [OPR] KOG2195 Transferrin receptor and related proteins ... 161 3e-39
Hs4507455 [OPR] KOG2195 Transferrin receptor and related protein... 130 1e-29
Hs4507457 [OPR] KOG2195 Transferrin receptor and related protein... 109 2e-23
At4g07670 [OPR] KOG2195 Transferrin receptor and related protein... 106 1e-22
Hs20470304 [OPR] KOG2195 Transferrin receptor and related protei... 80 9e-15
YPL176c [OPR] KOG2195 Transferrin receptor and related proteins ... 75 4e-13
YOR256c [OPR] KOG2195 Transferrin receptor and related proteins ... 63 2e-09
>YJR126c [OPR] KOG2195 Transferrin receptor and related proteins containing
the protease-associated (PA) domain
Length = 811
Score = 641 bits (1654), Expect = 0.0
Identities = 331/768 (43%), Positives = 468/768 (60%), Gaps = 10/768 (1%)
Query: 16 GVTRRRDNSVA---SFLA----RGRSNTINSLKSGFETVKKH--KNEFWLLIIGSLVLYL 66
G T R DN + SF RGRSNTI+S+ SG+E +K+H K +F LI+ SL+LY+
Sbjct: 43 GETTRDDNEESMNDSFTLTSRNRGRSNTISSIVSGYEIMKEHMDKEKFMYLILASLLLYM 102
Query: 67 GFTLAFLPRTSLSRDFRRLHFSKLTKSEAFRIYVETLMKENKCQDHLSNYTSHI-HWAGD 125
GF AF PRTSLSRDFRR H S+LT +E +RIY+ +L +EN+ ++H+ Y ++ + A D
Sbjct: 103 GFVAAFAPRTSLSRDFRRFHSSRLTNAEVYRIYLNSLQQENRAKEHVYKYAGYMSNGASD 162
Query: 126 AHALEYTINELSMLGFTPKLEEYHTWLNEPVKTEVTLWDQNHLLYNASMTEDYISEGEDN 185
+ +YT++E +G+ PK+E+Y+ W+ EPV T V + ++Y ASM ED + +
Sbjct: 163 SSTFKYTLDEFLDMGYKPKVEKYYPWIGEPVDTNVAPLENGKVVYEASMIEDRVKGDPAS 222
Query: 186 DSFKKVFGFHGFSANGTVRSEYVYCNYGTIEDYEHLLSHNVKLEGKIHVIRYGAIMKGIV 245
+ K+ GFH +S NG+V + YV+CNYG+I DY+ LL N+ +E KIH++R G I+ G+
Sbjct: 223 HARKRQKGFHQYSKNGSVTARYVFCNYGSISDYKLLLKKNIDIEDKIHIVRSGKILPGLK 282
Query: 246 VKNAETFGALGAILYTDSFDDGLITENNGYKPYPEGPARHESSIERGSVLLVDSVAGDPT 305
VKNAE +GA I+YTD FDDG +TE NG+ YP GPAR+ S I R SV GDPT
Sbjct: 283 VKNAELYGASSVIIYTDPFDDGKVTEENGFLHYPYGPARNPSYIRRDSVNYFSDTPGDPT 342
Query: 306 TPEYSSKHKDVKRLNSSSNLPTIPSVPMSEREIAPLLKLLNGNGIQWETKGNVKGFQYFS 365
TP Y SK D + ++ +P IPSVPMS R++ P+L+ LNG G Q N+K F F+
Sbjct: 343 TPGYPSKDSDTEHMSPVGRVPRIPSVPMSARDVQPILERLNGRGFQIGPGSNIKDFGSFT 402
Query: 366 GPSDAGVSCRIVNEQKYLTKEITNVVIEIPGILKEQEVIIGNHRDSWTXXXXXXXXXXXX 425
GPS + + NE Y KE+++V + IPGI E E+IIG HRDS
Sbjct: 403 GPSSSIDKVHLHNELTYNIKEMSSVEVSIPGIFTEGEIIIGAHRDSLASSSAGDANSGSA 462
Query: 426 ILLEIARGFSALHQKGWKPLRTIKLISWDGGEQGMLGSTEYGEYHRESLSKGTVAYFNLD 485
ILLEIARG S L + GWKPLR IKLISWDG G+LGST+Y E H L + + Y NLD
Sbjct: 463 ILLEIARGMSKLLKHGWKPLRPIKLISWDGERSGLLGSTDYAEAHAAILRRRALVYLNLD 522
Query: 486 LGVIGSKLNIKANPLLNELIVRSSKRTLFKEDPEVTLYDYWKESSNATIDILGAGTDFAV 545
+ G+ + KANPLL ++I ++K T F + +L+D+WK +SNATI +L + +
Sbjct: 523 NAISGTNFHCKANPLLQDVIYEAAKLTEFNGHEDWSLFDHWKYTSNATISLLDGLSSYTS 582
Query: 546 FQNNLGIPSIDFSFDRDPKKDAVHQFHSSYDSFEWMKTFVDPDFSLHSTMAMFVGVSTLS 605
FQ +LG+P+ F F+ + AV+ +S +DS W++ F + D+ LH+TMAMFVG++TL
Sbjct: 583 FQYHLGVPAAHFQFNANDTSGAVYHSNSVFDSPTWLEKFTNSDYKLHNTMAMFVGLTTLM 642
Query: 606 LTENELLGFKTHEYMIEISKYYKTLYSNISEVFPNDEMIMXXXXXXXXXXXXXXXXXXXX 665
L+ENEL F TH Y+ +I +Y +SN+S FP D+ +
Sbjct: 643 LSENELARFNTHVYLKKIYNWYIAWHSNLSSAFPQDDEVNSLAKRVLDLLKVATQEDSIQ 702
Query: 666 XXAMVDFVREQTQQDYPWWEWNKKLVILTRLISTNSKLRKLDRYFITDEGLKGRPFMKHS 725
+ ++ ++ P W + KK+ +L +NSK +++D+ FIT GLK R +MK+S
Sbjct: 703 FDQQNGILYKECREALPVWAFYKKIKSYIKLQRSNSKSKQIDQLFITHRGLKDREWMKYS 762
Query: 726 IFAPDKQTGYQGDVLPGLHEALLSENRQECIYWLETLLTQLDKISSLL 773
+ AP K G G+VLPGLHE L +R E I WL LL+Q + LL
Sbjct: 763 LLAPSKFEGSVGEVLPGLHEGLADIDRNEVIQWLTILLSQFSNVRYLL 810
>At5g19740 [OPR] KOG2195 Transferrin receptor and related proteins containing
the protease-associated (PA) domain
Length = 670
Score = 249 bits (637), Expect = 9e-66
Identities = 203/695 (29%), Positives = 320/695 (45%), Gaps = 84/695 (12%)
Query: 69 TLAFLPRTSLSRDFRRLHFSKLTKSEAFRIYVETLMKENKCQD-HLSNYTSHIHWAG--- 124
+LAF+ +LS F L FS KS +++ T +N +L T H AG
Sbjct: 6 SLAFVI-AALSYSFFSL-FSSPPKSHYHELFISTSFSDNASVALNLHTLTRRPHVAGTVA 63
Query: 125 DAHALEYTINELSMLGFTPKLEEYHTWLNEPVKTEVTLWDQNHLLYNASMTEDYISEGE- 183
+A A EY + + + Y L PV + L + ++ ++ E E
Sbjct: 64 NAEAAEYVRSVFTSSALKSHVVAYQVSLTYPVHRSLVLTPTD-----SAKPITFLLEQEK 118
Query: 184 --DNDSFKKVFG-FHGFSANGTVRSEYVYCNYGTIEDYEHLLSH-NVKLEGKIHVIRYGA 239
DN +V FHG++ +G V VY NYG +ED+ L V + G + + RYG
Sbjct: 119 LGDNPYANEVMPTFHGYAKSGNVSGPVVYANYGRVEDFVRLKKDMGVNVSGAVVIARYGQ 178
Query: 240 IMKGIVVKNAETFGALGAILYTDSFDDGLITENNGYKPYPEGPARHESSIERGSVLLVDS 299
I +G +VKNA GA+G ++YTD D G G + +P S ++ G+V +
Sbjct: 179 IYRGDIVKNAYEAGAVGVVIYTDKRDYG------GDEWFPASKWMPPSGVQVGTVY---N 229
Query: 300 VAGDPTTPEYSS----KHKDVKRLNSSSNLPTIPSVPMSEREIAPLLKLLNGNGIQWETK 355
GDPTTP ++S + + + S ++P IPS+P+S + +LK + G+ +
Sbjct: 230 GLGDPTTPGWASVDGCERLSDEAVELSGDVPLIPSLPVSAADAEVILKTVVGD----VSD 285
Query: 356 GNVKGFQYFSGPSDAGVSCRIVNEQKYLTKEITNVVIEIPGILK-EQEVIIGNHRDSWTX 414
G+V Y GP G + + +I NV+ I G + ++ VI+GNHRD+WT
Sbjct: 286 GDV----YPVGPGPGGET---------VIAKIENVIGVIEGEEEPDRYVILGNHRDAWTF 332
Query: 415 XXXXXXXXXXXILLEIARGFSALHQKGWKPLRTIKLISWDGGEQGMLGSTEYGEYHRESL 474
IA+ L ++GWKP RTI L +WD E G++GSTE+ E +RE L
Sbjct: 333 GAVDPNSGTA-----IAQRLDKLQKRGWKPRRTIILCNWDAEEYGLIGSTEWVEENREML 387
Query: 475 SKGTVAYFNLDLGVIGSKLNIKANPLLNELIVRSSKRTLFKEDPEVTLYDYWKESSNATI 534
S VAY N+D V G + A P L+ELI +++ ++ T+Y+ W SS++ +
Sbjct: 388 SSRAVAYLNVDCAVSGPGFHASATPQLDELIKVAAQEVRDPDNATQTIYESWIGSSDSVV 447
Query: 535 --DILGAGTDFAVFQNNLGIPSIDFSFDRDPKKDAVHQFHSSYDSFEWMKTFVDPDFSLH 592
+ G G+D+A F ++G+P +D SF R +HS YD F WM+ F DP F H
Sbjct: 448 IRRLGGGGSDYASFVQHVGVPGVDMSFGR-----GYPVYHSMYDDFTWMEKFGDPMFQRH 502
Query: 593 STMAMFVGVSTLSLTENELLGFKTHEYMIEISKYYKTLYSNISEVFPNDEMIMXXXXXXX 652
MA +G+ L L + E++ F Y +E+ K +E N+++
Sbjct: 503 VAMASVLGLVALRLADEEIIPFNYTSYALELKK--------SAEDLENEKL----GHNID 550
Query: 653 XXXXXXXXXXXXXXXAMVDFVREQTQQDYPWWEWNKKLVILTRLISTNSKLRKLDRYFIT 712
+ +E + E N +L++ R ++ DR
Sbjct: 551 VSTLIKSIEDLSTAAKHISLEKEAIKGALKVRELNDRLMMAERALT--------DR---- 598
Query: 713 DEGLKGRPFMKHSIFAPDKQTGYQGDVLPGLHEAL 747
+GL RP+ KH I+ P K Y PG+ +A+
Sbjct: 599 -DGLSERPWYKHLIYGPSKYDDYGSKSFPGVDDAI 632
>Hs4758398 [OPR] KOG2195 Transferrin receptor and related proteins containing
the protease-associated (PA) domain
Length = 750
Score = 236 bits (603), Expect = 8e-62
Identities = 215/749 (28%), Positives = 338/749 (44%), Gaps = 75/749 (10%)
Query: 35 NTINSLKSGFETVKKHKNEFWLLIIGSLVL-----YLGFTLAFLPRTSLSRDFRRLHFSK 89
N ++ S T ++ + WL G+LVL LGF + ++S +
Sbjct: 3 NLLHETDSAVATARRPR---WLCA-GALVLAGGFFLLGFLFGWFIKSSNEA-------TN 51
Query: 90 LTKSEAFRIYVETLMKENKCQDHLSNYTSHIHWAGDAHALEYTINELSM---LGF-TPKL 145
+T + +++ L EN + L N+T H AG + S G + +L
Sbjct: 52 ITPKHNMKAFLDELKAEN-IKKFLYNFTQIPHLAGTEQNFQLAKQIQSQWKEFGLDSVEL 110
Query: 146 EEYHTWLNEPVKTEVT----LWDQNHLLYNASMTEDYISEGEDNDSFKKVFGFHGFSANG 201
Y L+ P KT + + + ++N S+ E G +N S V F FS G
Sbjct: 111 AHYDVLLSYPNKTHPNYISIINEDGNEIFNTSLFEPP-PPGYENVS-DIVPPFSAFSPQG 168
Query: 202 TVRSEYVYCNYGTIEDYEHL-LSHNVKLEGKIHVIRYGAIMKGIVVKNAETFGALGAILY 260
+ VY NY ED+ L + GKI + RYG + +G VKNA+ GA G ILY
Sbjct: 169 MPEGDLVYVNYARTEDFFKLERDMKINCSGKIVIARYGKVFRGNKVKNAQLAGAKGVILY 228
Query: 261 TDSFDDGLITENNGYKPYPEGPARHESSIERGSVLLVDSVAGDPTTPEYSSKHKDVKR-L 319
+D D G K YP+G ++RG++L ++ AGDP TP Y + +R +
Sbjct: 229 SDPADYFA----PGVKSYPDGWNLPGGGVQRGNILNLNG-AGDPLTPGYPANEYAYRRGI 283
Query: 320 NSSSNLPTIPSVPMSEREIAPLLKLLNGNG---IQWETKGNVKGFQYFSGPSDAG-VSCR 375
+ LP+IP P+ + LL+ + G+ W +G++K Y GP G S +
Sbjct: 284 AEAVGLPSIPVHPIGYYDAQKLLEKMGGSAPPDSSW--RGSLK-VPYNVGPGFTGNFSTQ 340
Query: 376 IVNEQKYLTKEIT---NVVIEIPGILK-EQEVIIGNHRDSWTXXXXXXXXXXXXILLEIA 431
V + T E+T NV+ + G ++ ++ VI+G HRDSW ++ EI
Sbjct: 341 KVKMHIHSTNEVTRIYNVIGTLRGAVEPDRYVILGGHRDSWVFGGIDPQSGAA-VVHEIV 399
Query: 432 RGFSALHQKGWKPLRTIKLISWDGGEQGMLGSTEYGEYHRESLSKGTVAYFNLDLGVIGS 491
R F L ++GW+P RTI SWD E G+LGSTE+ E + L + VAY N D + G+
Sbjct: 400 RSFGTLKKEGWRPRRTILFASWDAEEFGLLGSTEWAEENSRLLQERGVAYINADSSIEGN 459
Query: 492 -KLNIKANPLLNELIVRSSKRTLFKED--PEVTLYDYWKESSNA-------TIDILGAGT 541
L + PL+ L+ +K ++ +LY+ W + S + I LG+G
Sbjct: 460 YTLRVDCTPLMYSLVHNLTKELKSPDEGFEGKSLYESWTKKSPSPEFSGMPRISKLGSGN 519
Query: 542 DFAVFQNNLGIPSIDFSFDRD---PKKDAVHQFHSSYDSFEWMKTFVDPDFSLHSTMAMF 598
DF VF LGI S + ++ K +HS Y+++E ++ F DP F H T+A
Sbjct: 520 DFEVFFQRLGIASGRARYTKNWETNKFSGYPLYHSVYETYELVEKFYDPMFKYHLTVAQV 579
Query: 599 VGVSTLSLTENELLGFKTHEYMIEISKYYKTLYSNISEVFPNDEMIMXXXXXXXXXXXXX 658
G L + +L F +Y + + KY +YS IS P +
Sbjct: 580 RGGMVFELANSIVLPFDCRDYAVVLRKYADKIYS-ISMKHPQE-------------MKTY 625
Query: 659 XXXXXXXXXAMVDFVREQTQQDYPWWEWNKKLVILTRLISTNSKLRKLDRYFITDEGLKG 718
A+ +F ++ +++K I+ R++ N +L L+R FI GL
Sbjct: 626 SVSFDSLFSAVKNFTEIASKFSERLQDFDKSNPIVLRMM--NDQLMFLERAFIDPLGLPD 683
Query: 719 RPFMKHSIFAPDKQTGYQGDVLPGLHEAL 747
RPF +H I+AP Y G+ PG+++AL
Sbjct: 684 RPFYRHVIYAPSSHNKYAGESFPGIYDAL 712
>Hs4885505 [OPR] KOG2195 Transferrin receptor and related proteins containing
the protease-associated (PA) domain
Length = 740
Score = 231 bits (589), Expect = 3e-60
Identities = 179/580 (30%), Positives = 275/580 (46%), Gaps = 43/580 (7%)
Query: 194 FHGFSANGTVRSEYVYCNYGTIEDYEHLLSH-NVKLEGKIHVIRYGAIMKGIVVKNAETF 252
++ FSA G + VY NY ED+ L + GKI + RYG I +G VKNA
Sbjct: 151 YNAFSAQGMPEGDLVYVNYARTEDFFKLEREMGINCTGKIVIARYGKIFRGNKVKNAMLA 210
Query: 253 GALGAILYTDSFDDGLITENNGYKPYPEGPARHESSIERGSVLLVDSVAGDPTTPEYSSK 312
GA+G ILY+D D +PYP+G ++ +RG+VL ++ AGDP TP Y +K
Sbjct: 211 GAIGIILYSDPADYFAPE----VQPYPKGWNLPGTAAQRGNVLNLNG-AGDPLTPGYPAK 265
Query: 313 HKDVKR-LNSSSNLPTIPSVPMSEREIAPLLKLLNGNGIQWETKGNVKGFQYFSGPSDAG 371
+ + +P IP P+ + LL+ L G ++ Y GP G
Sbjct: 266 EYTFRLDVEEGVGIPRIPVHPIGYNDAEILLRYLGGIAPPDKSWKGALNVSYSIGPGFTG 325
Query: 372 V-SCRIVNEQKYLTKEIT---NVVIEIPGILK-EQEVIIGNHRDSWTXXXXXXXXXXXXI 426
S R V Y +IT NVV I G ++ ++ VI+G HRDSW +
Sbjct: 326 SDSFRKVRMHVYNINKITRIYNVVGTIRGSVEPDRYVILGGHRDSWVFGAIDPTSGVA-V 384
Query: 427 LLEIARGFSALHQKGWKPLRTIKLISWDGGEQGMLGSTEYGEYHRESLSKGTVAYFNLDL 486
L EIAR F L KGW+P RTI SWD E G+LGSTE+ E + + L + ++AY N D
Sbjct: 385 LQEIARSFGKLMSKGWRPRRTIIFASWDAEEFGLLGSTEWAEENVKILQERSIAYINSDS 444
Query: 487 GVIGS-KLNIKANPLLNELIVRSSKRTLFKED--PEVTLYDYWKESSNA-------TIDI 536
+ G+ L + PLL +L+ + +K +D +LY+ W E + I+
Sbjct: 445 SIEGNYTLRVDCTPLLYQLVYKLTKEIPSPDDGFESKSLYESWLEKDPSPENKNLPRINK 504
Query: 537 LGAGTDFAVFQNNLGIPSIDFSFDRDPKKDAVHQ---FHSSYDSFEWMKTFVDPDFSLHS 593
LG+G+DF + LGI S + ++ K D +H+ Y++FE ++ F DP F
Sbjct: 505 LGSGSDFEAYFQRLGIASGRARYTKNKKTDKYSSYPVYHTIYETFELVEKFYDPTFKKQL 564
Query: 594 TMAMFVGVSTLSLTENELLGFKTHEYMIEISKYYKTLYSNISEVFPNDEMIMXXXXXXXX 653
++A G L +++++ F +Y + Y ++Y N+S+ +D+ +
Sbjct: 565 SVAQLRGALVYELVDSKIIPFNIQDYAEALKNYAASIY-NLSK--KHDQQL----TDHGV 617
Query: 654 XXXXXXXXXXXXXXAMVDFVREQTQQDYPWWEWNKKLVILTRLISTNSKLRKLDRYFITD 713
A DF + Q D N + + R++ N +L L+R FI
Sbjct: 618 SFDSLFSAVKNFSEAASDFHKRLIQVDL-----NNPIAV--RMM--NDQLMLLERAFIDP 668
Query: 714 EGLKGRPFMKHSIFAPDKQTGYQGDVLPGLHEALLS-ENR 752
GL G+ F +H IFAP Y G+ PG+++A+ EN+
Sbjct: 669 LGLPGKLFYRHIIFAPSSHNKYAGESFPGIYDAIFDIENK 708
>Hs20480969 [OPR] KOG2195 Transferrin receptor and related proteins containing
the protease-associated (PA) domain
Length = 693
Score = 228 bits (581), Expect = 3e-59
Identities = 198/682 (29%), Positives = 310/682 (45%), Gaps = 59/682 (8%)
Query: 97 RIYVETLMKENKCQDHLSNYTSHIHWAGDAHALEYTINELSM---LGF-TPKLEEYHTWL 152
+ +++ L EN + L N+T H AG + S G + +L Y L
Sbjct: 2 KAFLDELKAEN-IKKFLYNFTQIPHLAGTEQNFQLAKQIQSQWKEFGLDSAELAHYDVLL 60
Query: 153 NEPVKTEVT----LWDQNHLLYNASMTEDYISEGEDNDSFKKVFGFHGFSANGTVRSEYV 208
+ P KT + + + ++N S+ E G +N S V F FS G + V
Sbjct: 61 SYPNKTHPNYISIINEDGNEIFNTSLFEPP-PPGYENVS-DIVPSFSAFSPQGMPEGDLV 118
Query: 209 YCNYGTIEDYEHL-LSHNVKLEGKIHVIRYGAIMKGIVVKNAETFGALGAILYTDSFDDG 267
+ NY ED+ L + GKI + RY + +G VKNA+ GA G ILY+D D
Sbjct: 119 HVNYARTEDFFKLERDMKINCSGKIVIARYRKVFRGNKVKNAQLAGAKGVILYSDPADYF 178
Query: 268 LITENNGYKPYPEGPARHESSIERGSVLLVDSVAGDPTTPEYSSKHKDVKR-LNSSSNLP 326
G K YP+G ++RG++L ++ AGDP TP Y + + + + LP
Sbjct: 179 A----PGVKSYPDGWNLPGGGVQRGNILNLNG-AGDPLTPGYPANEYAYRHGIAEAVGLP 233
Query: 327 TIPSVPMSEREIAPLLKLLNGNG---IQWETKGNVKGFQYFSGPSDAG-VSCRIVNEQKY 382
+IP P+ + LL+ + G+ W +G++K Y GP G S + V +
Sbjct: 234 SIPVHPVGYYDAQKLLEKMGGSAPPDSSW--RGSLK-VSYNVGPGFTGNFSTQKVKMHIH 290
Query: 383 LTKEIT---NVVIEIPGILK-EQEVIIGNHRDSWTXXXXXXXXXXXXILLEIARGFSALH 438
T E+T NV+ + G ++ ++ VI+G HRDSW ++ E R F L
Sbjct: 291 STNEVTRIYNVIGTLRGAVEPDRYVILGGHRDSWVFGGIDPQSGAA-VVHETVRSFGTLK 349
Query: 439 QKGWKPLRTIKLISWDGGEQGMLGSTEYGEYHRESLSKGTVAYFNLDLGVIGS-KLNIKA 497
++GW+P RTI SWD E G+LGSTE+ E + L + VAY N D + G+ L +
Sbjct: 350 KEGWRPRRTILFASWDAEEFGLLGSTEWAEDNSRLLQERGVAYINADSSIEGNYTLRVDC 409
Query: 498 NPLLNELIVRSSKRTLFKED--PEVTLYDYWKESSNA-------TIDILGAGTDFAVFQN 548
PL+ L+ +K ++ +LY+ W + S + I LG+G DF VF
Sbjct: 410 TPLMYSLVYNLTKELKSPDEGFEGKSLYESWTKKSPSPEFSGMPRISKLGSGNDFEVFFQ 469
Query: 549 NLGIPSIDFSFDRD---PKKDAVHQFHSSYDSFEWMKTFVDPDFSLHSTMAMFVGVSTLS 605
LGI S + ++ K +HS Y+++E ++ F DP F H T+A G
Sbjct: 470 RLGIASGRARYTKNWETNKFSGYPLYHSVYETYELVEKFYDPMFKYHLTVAQVRGGMVFE 529
Query: 606 LTENELLGFKTHEYMIEISKYYKTLYSNISEVFPNDEMIMXXXXXXXXXXXXXXXXXXXX 665
L + +L F +Y + + KY +Y NIS P +
Sbjct: 530 LANSIVLPFDCRDYAVVLRKYADKIY-NISMKHPQE-------------MKTYSLSFDSL 575
Query: 666 XXAMVDFVREQTQQDYPWWEWNKKLVILTRLISTNSKLRKLDRYFITDEGLKGRPFMKHS 725
A+ +F ++ +++K IL R++ N +L L+R FI GL RPF +H
Sbjct: 576 FSAVKNFTEIASKFSERLQDFDKSNPILLRMM--NDQLMFLERAFIDPLGLPDRPFYRHV 633
Query: 726 IFAPDKQTGYQGDVLPGLHEAL 747
I+AP Y G+ PG+++AL
Sbjct: 634 IYAPSSHNKYAGESFPGIYDAL 655
>At3g54720 [OPR] KOG2195 Transferrin receptor and related proteins containing
the protease-associated (PA) domain
Length = 703
Score = 209 bits (533), Expect = 1e-53
Identities = 181/651 (27%), Positives = 286/651 (43%), Gaps = 74/651 (11%)
Query: 112 HLSNYTSHIHWAGDAHALE---YTINELSMLGFTPKLEEYHTWLNEPVKTEVTLWDQNHL 168
+L T H H AG +L+ Y N LG + EY L+ P VT N
Sbjct: 80 YLRELTRHPHLAGTKPSLDTLHYVFNHFQSLGLETHVAEYEALLSYPTHISVTASFSN-- 137
Query: 169 LYNASMTEDYISEGEDNDSFKKVFGFHGFSANGTVRSEYVYCNYGTIEDYEHLLSHNVKL 228
+ T ++ DS V +H +S +G+ + V+ N+G DY L S V +
Sbjct: 138 ----TTTLEFDLNDVPGDS-PVVRPYHAYSPSGSAQGNVVFVNHGEERDYHALESIGVSV 192
Query: 229 EGKIHVIRYGAIM-KGIVVKNAETFGALGAILYTDSFDDGLITENNGYKPYPEGPARHES 287
+G + + R G + +G +VK AE GALG ++Y ++ G
Sbjct: 193 KGCVVLARKGENLGRGAIVKIAEAKGALGVLIYAENDGGGF------------------G 234
Query: 288 SIERGSVLLVDSVAGDPTTPEYSSKHKDVKRLNSSSNL-----PTIPSVPMSEREIAPLL 342
IERG+V+ GDP +P + K L+ L P IPS+P+S R +L
Sbjct: 235 GIERGTVM---RGIGDPVSPGWPGVVGGEK-LSLDDELVTRRFPKIPSLPLSLRNAEIIL 290
Query: 343 KLLNGNG--IQWETKGNVKGFQYFSGPSDAGVSCRIVNEQKYLTKEITNVVIEIPGILK- 399
L G ++W G V Q GP ++ E K K+I NVV+ I G +
Sbjct: 291 ASLGGARAPLEWRNSGRVGPGQRV-GPGRMVINMTFQGEMKM--KKINNVVVTIRGSEEA 347
Query: 400 EQEVIIGNHRDSWTXXXXXXXXXXXXILLEIARGFSALHQKGWKPLRTIKLISWDGGEQG 459
++ VI+GNHRD+WT LL+I+R F+ L + GW+P RTI L SWD E G
Sbjct: 348 DRYVILGNHRDAWTYGAVDPNSGTSA-LLDISRRFALLLKSGWRPRRTILLCSWDAEEFG 406
Query: 460 MLGSTEYGEYHRESLSKGTVAYFNLDLGVIGSKLNIKANPLLNELIVRSSKRTLFKEDPE 519
M+GSTE+ E + +L VAY N+D V GS A P L+ L+V + K DP+
Sbjct: 407 MIGSTEWIEENVLNLGASAVAYLNVDCAVQGSGFFAGATPQLDGLLV-----DVLKLDPD 461
Query: 520 ---VTLYDYWKESSNATIDILGAGTDFAVFQNNLGIPSIDFSFDRDPKKDAVHQFHSSYD 576
+T+ + +K +N + +DF+ F ++ GIPSID + D +H+++D
Sbjct: 462 AVGLTVEETFKSQNNIIQRLSRVDSDFSGFLHHAGIPSIDMYYGAD-----YPVYHTAFD 516
Query: 577 SFEWMKTFVDPDFSLHSTMAMFVGVSTLSLTENELLGFKTHEYMIEISKYYKTLYSNISE 636
S++WM DP F H MA G+ + L + L+ F Y ++ + L +
Sbjct: 517 SYDWMIHNADPLFHRHVAMAGIWGLLGILLADEPLIPFDYISYADQLQAHRDKLSKLLEG 576
Query: 637 VFPNDEMIMXXXXXXXXXXXXXXXXXXXXXXAMVDFVREQTQQDYPWWEWNKKLVILTRL 696
+ + M D ++ + Y + +
Sbjct: 577 KVSVNPLSMAIQEFSLVAKEA------------ADEAKKLKGKSYS----KNDVAAAAKR 620
Query: 697 ISTNSKLRKLDRYFITDEGLKGRPFMKHSIFAPDKQTGYQGDVLPGLHEAL 747
N +L ++R F+ EG+KG+ + KH ++ P + + PG+ +A+
Sbjct: 621 RELNDRLMLVERGFLDAEGIKGKEWFKHLVYGPAAEPESKLGFFPGIADAI 671
>Hs4885507 [OPR] KOG2195 Transferrin receptor and related proteins containing
the protease-associated (PA) domain
Length = 740
Score = 191 bits (486), Expect = 3e-48
Identities = 136/453 (30%), Positives = 223/453 (49%), Gaps = 37/453 (8%)
Query: 194 FHGFSANGTVRSEYVYCNYGTIEDYEHLLSHNVKLEGKIHVIRYGAIMKGIVVKNAETFG 253
+ ++ +GT + VY N G ED++ L + +KLEG I + RYG + +G NA G
Sbjct: 150 YAAYAPSGTPQGLLVYANRGAEEDFKELQTQGIKLEGTIALTRYGGVGRGAKAVNAAKHG 209
Query: 254 ALGAILYTDSFD--DGLITENNGYKPYPEGPARHESSIERGSVLLVDSVAGDPTTPEYSS 311
G ++YTD D DGL + + + +P S +ERGS GDP TP +
Sbjct: 210 VAGVLVYTDPADINDGLSSPD---ETFPNSWYLPPSGVERGSYY---EYFGDPLTPYLPA 263
Query: 312 KHKDVK-RLNSSSNLPTIPSVPMSEREIAPLLKLLNGNGIQWETKGNVKGFQYFSG---- 366
+ L + S P IP+ P+ ++ LL LNG + T G Y G
Sbjct: 264 VPSSFRVDLANVSGFPPIPTQPIGFQDARDLLCNLNGT-LAPATWQGALGCHYRLGPGFR 322
Query: 367 -----PSDAGVSCRIVNEQKYLTKEITNVVIEIPGILK-EQEVIIGNHRDSWTXXXXXXX 420
P+D+ V+ + N + + +NV+ I G ++ ++ V+ GNHRDSW
Sbjct: 323 PDGDFPADSQVNVSVYNRLE--LRNSSNVLGIIRGAVEPDRYVLYGNHRDSWV-HGAVDP 379
Query: 421 XXXXXILLEIARGFSALHQKG-WKPLRTIKLISWDGGEQGMLGSTEYGEYHRESLSKGTV 479
+LLE++R L +KG W+P R+I SW E G++GSTE+ E L + TV
Sbjct: 380 SSGTAVLLELSRVLGTLLKKGTWRPRRSIVFASWGAEEFGLIGSTEFTEEFFNKLQERTV 439
Query: 480 AYFNLDLGVI-GSKLNIKANPLLNELIVRSSKRTLFKEDPEVTLYDYWKESSNATIDI-- 536
AY N+D+ V + L ++ P + ++ ++K ++++YD W N + +
Sbjct: 440 AYINVDISVFANATLRVQGTPPVQSVVFSATKEIRSPGPGDLSIYDNWIRYFNRSSPVYG 499
Query: 537 -------LGAGTDFAVFQNNLGIPSIDFSFDRDPKKDAVH---QFHSSYDSFEWMKTFVD 586
LGAG+D+A F + LGI S+D ++ D K + +H+++D+F+++ F+D
Sbjct: 500 LVPSLGSLGAGSDYAPFVHFLGISSMDIAYTYDRSKTSARIYPTYHTAFDTFDYVDKFLD 559
Query: 587 PDFSLHSTMAMFVGVSTLSLTENELLGFKTHEY 619
P FS H +A G L L+++ L K +Y
Sbjct: 560 PGFSSHQAVARTAGSVILRLSDSFFLPLKVSDY 592
>CE12844 [OPR] KOG2195 Transferrin receptor and related proteins containing
the protease-associated (PA) domain
Length = 751
Score = 188 bits (478), Expect = 2e-47
Identities = 180/725 (24%), Positives = 316/725 (42%), Gaps = 64/725 (8%)
Query: 82 FRRLHFSKLTKSEAFRIYVETLMKENKCQDHLSNYTSHIHWAGDAHALEYTINELSMLGF 141
F ++ + KS+A ++ +K + +L +T H AG A + E++
Sbjct: 33 FNKVSIDDIHKSDAG--VIQDNIKTENIKKYLRIFTKDPHVAG-TEANKKVAYEIANAWS 89
Query: 142 TPKLEEYHTWLNEPVKTEVTLWDQNHLLYNASMTED-YISEGED-----NDSFKKVFGFH 195
LE+ HT E + + + N ++ +S ++ + S+G ++ K G
Sbjct: 90 EAGLEDVHTLPYEVLLSYPDFENPNSVIIKSSAGKEVFKSKGVSPVIIPDEQSGKYAGHQ 149
Query: 196 --GFSANGTVRSEYVYCNYGTIEDYEHLLSHNVKLEGKIHVIRYGAIMKGIVVKNAETFG 253
++ NG+ ++ VY N+GT D+++L V ++GKI ++RYG +G + A+ G
Sbjct: 150 WLAYAGNGSASADVVYINHGTANDFKNLKLMGVDIKGKIALMRYGHGFRGDKIHKAQQAG 209
Query: 254 ALGAILYTDSFD---DGLITENNGYKPYPEGPARHESSIERGSVLLVDSVAGDPTTPEYS 310
A+GAIL++D+ D DG+ +EN YP+ ++RGS++ D GD +P Y
Sbjct: 210 AIGAILFSDTQDVAQDGVESEN----VYPKKIWMPNEGVQRGSLMHGD---GDALSPYYP 262
Query: 311 SKH-----KDVKRLNSSSNLPTIPSVPMSEREIAPLLKLLNGNGIQWETKGNVKG-FQYF 364
SK + ++ LP+IP +P+S +LK L+G + +G V G Y
Sbjct: 263 SKKELFKGRTIEEAKEDGVLPSIPVLPVSYTTGYEILKRLSGRPAPSDWQGFVGGNLTYK 322
Query: 365 SGPSDAGVSCRIVNEQKYL-TKEITNVVIEIPGILK-EQEVIIGNHRDSWTXXXXXXXXX 422
GP +N L TK I NV+ I G + + +++GNH D+W
Sbjct: 323 LGPGFVNGEKLSINVHSELRTKRIRNVIGYIRGSEEPDSYIMLGNHFDAWV-YGSIDPNS 381
Query: 423 XXXILLEIARG-FSALHQKGWKPLRTIKLISWDGGEQGMLGSTEYGEYHRESLSKGTVAY 481
+L E+AR +++ WKP RTI +WD E G++GSTE+ E L K V Y
Sbjct: 382 GTAVLAEVARAMMQTINETSWKPARTIVFNAWDAEEFGLIGSTEFVEEFVNILQKRAVVY 441
Query: 482 FNLDLGVIGSKLNIKANPLLNELIVRSSKRTLFKEDP--------EVTLYDYW------K 527
N+D L++ P+L ++ +SK+ E+P TLYD W K
Sbjct: 442 INMDCIQGNISLHVDTVPILEHAVIEASKQV---ENPSKRERSRGRKTLYDTWMKVFPDK 498
Query: 528 ESSNATIDILGAGTDFAVFQNNLGIPSIDFSFDRDPKKDAVHQFHSSYDS-FEWMKTFVD 586
++ I + G G+D A F N G+P I+F+F D +H+ Y++ F +
Sbjct: 499 KAGVPKIRVPGGGSDHAPFLNFAGVPVINFTFKNYTTWDTYPLYHTMYETPFSNIHLLDT 558
Query: 587 PDFSLHSTMAMFVGVSTLSLTENELLGFKTHEYMIEISKYY----KTLYSNISEVFPNDE 642
+ S+H + + + ++ +L T + + K Y KT S I+ V +D
Sbjct: 559 DNLSVHKAIGQYWAELAKTFADDVILPMNTTHFASVMLKTYLPQLKTTISGIN-VSRSDF 617
Query: 643 MIMXXXXXXXXXXXXXXXXXXXXXXAMVDFVREQTQQDYPWWEWNKKLVILTRLISTNSK 702
+ + F TQ + ++ K + + N +
Sbjct: 618 EDIRTQYALLSKSAQDLLTMSKKFQETIHF----TQHSFSQNPYDPK-----HVNAVNER 668
Query: 703 LRKLDRYFITDEGLK-GRPFMKHSIFAPDKQTGYQGDVLPGLHEALLSENRQECIYWLET 761
L+ +R FI G+ P +H +F+ Y ++ G+ A+ S + L
Sbjct: 669 LKSTERCFINPRGVSMHNPSARHVLFSVSDSDSYSSSLMAGVQNAINSYDLNPTKKGLRE 728
Query: 762 LLTQL 766
++ Q+
Sbjct: 729 IINQI 733
>SPBC354.09c [OPR] KOG2195 Transferrin receptor and related proteins containing
the protease-associated (PA) domain
Length = 794
Score = 173 bits (438), Expect = 1e-42
Identities = 156/646 (24%), Positives = 282/646 (43%), Gaps = 61/646 (9%)
Query: 124 GDAHALEYTINELSM-LGFTPKLEEYHTWLNEPVKTEVTLWDQNHLLYNASMTEDYISEG 182
GD+ L+ +N L G E++ +LN P +++ + ++ S+ E Y G
Sbjct: 161 GDSSLLQMIMNRLYYEKGTIVDFREFYAYLNFPQLVSLSIDGDDS--FHPSLIESYQVGG 218
Query: 183 EDNDSFKKVFGFHGFSANGTVRSEYVYCNYGTIEDYEHLLSHNVKLEGKIHVIRYGAIMK 242
D S F G S +G V + VY N G IED+E L++ + +E I ++R
Sbjct: 219 YDGVSIPTPATFGG-SPSGFVNAPLVYANRGRIEDFEWLVNSGIYVESSIVLVRANQSDF 277
Query: 243 GIVVKNAETFGALGAILYTDSFDDGLITENNGYKPYPEGPARHESSIERGSVLLVDSVAG 302
+ NAE + A +++ D++ L + +N + YP GP +S+ RGSV G
Sbjct: 278 ALATANAEKYNASAILIFEDTY---LTSLDNLNQVYPAGPYPSANSLYRGSVANHYYYVG 334
Query: 303 DPTTPEYSSKHKDVKRLN--SSSNLPTIPSVPMSEREIAPLLKLLNGNGIQWETKGNVKG 360
DP TP +S+ H++ R++ ++ LP+I S+P++ + LLK L G+G + +
Sbjct: 335 DPLTPGWSA-HEETNRISPKDANVLPSIVSIPITFNDGIELLKRLQGHGHLVKDSNWCQD 393
Query: 361 F-----QYFSGP--SDAGVSCRIVNEQKYLTKEITNVVIEIPGILKEQEVIIGNHRDSWT 413
+ ++G S G+ ++ + + K I N++ +I G +Q +++G RDSW
Sbjct: 394 LAPVLSEVWTGSKISSPGLEVNVLQDIEDKQK-IINIMAQIDGYESDQILVVGAPRDSWC 452
Query: 414 XXXXXXXXXXXXILLEIARGFSALHQK-GWKPLRTIKLISWDGGEQGMLGSTEYGEYHRE 472
+L+++ F+ + Q WKP RTI SWD + +GSTE+ EY +E
Sbjct: 453 TGASDSSVGTS-LLIDVISTFANMAQDLSWKPRRTIVFASWDARQFNAIGSTEFLEYWKE 511
Query: 473 SLSKGTVAYFNLDLGVIGSKLNIKANPLLNELIVRSSKRTLFKEDPEVTLYDYWKESSNA 532
SL VAY N+D+ V G + P L ++I R+ + E+ E+ +++N
Sbjct: 512 SLEAKAVAYINVDVAVSGDTFTARTVPGLKKVIQRAF--DVANEEDEM-------KAANI 562
Query: 533 TIDILGAGTDFAVFQNNLGIPSIDFSFDRDPKKDAVHQF-HSSYDSFEWMKTFVDPDFSL 591
D +D F GIP ++ +F+R+ + F S D+ W+ TF +
Sbjct: 563 ITDDFDYTSDLTSFLTFAGIPVVNLAFERNEENPTPMPFLGSCEDTVSWIDTFGSEYWEN 622
Query: 592 HSTMAMFVGVSTLSLTENELLGFKTHEYMIEISKYYKTLYSNISEVFPNDEMIMXXXXXX 651
+ + L L + ++ + + + + + E+ I
Sbjct: 623 AARLGKIWSYLILFLANDPVVPYDLEDEI-----------NGVGEMLKRIPEIPGANALD 671
Query: 652 XXXXXXXXXXXXXXXXAMVDFVREQTQQDYPWWEWNKKLVILTRLIST---------NSK 702
D +R EW ++ + +S N+K
Sbjct: 672 LRKINEEFSELLESLIRFEDEIR----------EWKSLMMHNSYTVSVKKHPELEGYNAK 721
Query: 703 LRKLDRYFITDEGLKGRPFMKHSIFAPDKQTGYQGDVLPGLHEALL 748
L + +R F+ + GL G + KH I+ P+ + + + P + +ALL
Sbjct: 722 LARFERSFLDEAGLPGHEWYKHLIYGPNLRNSH-SQLFPSIFDALL 766
>CE08584 [OPR] KOG2195 Transferrin receptor and related proteins containing
the protease-associated (PA) domain
Length = 1483
Score = 161 bits (408), Expect = 3e-39
Identities = 164/723 (22%), Positives = 299/723 (40%), Gaps = 67/723 (9%)
Query: 100 VETLMKENKCQDHLSNYTSHIHWAGDAHAL---EYTINELSMLGF-TPKLEEYHTWLNEP 155
++ L+ + + +L + T H AG + L E +++ G EY+ L+ P
Sbjct: 67 IKQLINVDNIRSNLHSLTKKPHVAGTENNLRVAEMIRDQMITQGLENVHFNEYNVMLSYP 126
Query: 156 VKTEVT----LWDQNHLLYNASMTEDYISEGEDNDSFKKVFGFHGFSANGTVRSEYVYCN 211
T L + L+++ + + + E ND ++ + +SA GTV + VY N
Sbjct: 127 NWTTPNIIEILKENRDLVFSTTGRSVSVIKEEQNDPLAEI-QWLAYSAAGTVEGDIVYVN 185
Query: 212 YGTIEDYEHLLSHNVKLEGKIHVIRYGAIMKGIVVKNAETFGALGAILYTDSFDDGLITE 271
D E+L S + L+ KI + RY + +G + + A GA ++Y+D +
Sbjct: 186 NANPSDIEYLESLGIDLKDKIFLARYSSNYRGNIAQMAVKKGAKACLVYSDPKQVASLGT 245
Query: 272 NNGYKPYPEGPARHESSIERGSVLLVDSVAGDPTTPEYSS-----KHKDVKRLNSSSNLP 326
+ Y ++++ GSV + GDP TP + S K K + L +P
Sbjct: 246 GPN-ETYGNTDKMPSNTVQMGSVYIG---LGDPRTPAFPSIGDLFKEKTEQDLLDEKKIP 301
Query: 327 TIPSVPMSEREIAPLLKLLNGNGIQWETKGNVKGFQYFSGPS-----DAGVSCRIVNEQK 381
TIP +P++ L + + G+ + + +G + Y GP V+ NE++
Sbjct: 302 TIPMLPITYATAQILFENMKGDAVNADFQGKLN-VTYRYGPGLINNQKLRVTVHAENEER 360
Query: 382 YLT------------KEITNVVIEIPGILKEQE-VIIGNHRDSWTXXXXXXXXXXXXILL 428
+ ++I N++ I G + + V++ NH D+WT LL
Sbjct: 361 SVIVVELISRLRLNFRKIQNIMGYIKGSQEPDKFVLVSNHYDAWTYGAVDPNSGTST-LL 419
Query: 429 EIARGFSAL-HQKGWKPLRTIKLISWDGGEQGMLGSTEYGEYHRESLSKGTVAYFNLDLG 487
E++R +Q GW P R+I WD E G++GSTE+ E +R L + VA N+DL
Sbjct: 420 EVSRALKQYQNQTGWIPARSILFAHWDAEEYGLIGSTEFAEEYRLQLMRRAVAVINMDLI 479
Query: 488 VIGSKLNIKANPLLNELIVRSSKRTLFKEDP------EVTLYDYWK--------ESSNAT 533
L +NP + ++RS+ + + +P TLYD WK S++
Sbjct: 480 GGNQTLLGLSNPTVAN-VLRSAAANVEQPNPTEMEQGRKTLYDSWKYYAPSKNNRSTHPY 538
Query: 534 IDILGAGTDFAVFQNNLGIPSIDFSFDRDPKKDAVHQFHSSYDSFEWMKTFVDPDFSLHS 593
I G+D F + LGIP + F +H+ Y++ ++ +DP + +H
Sbjct: 539 QRIPAGGSDHLPFFDYLGIPIVFFITSSLDAPPTYPLYHTIYETPYLIENIMDPGYKVHK 598
Query: 594 TMAMFVGVSTLSLTENELLGFKTHEYMIE-ISKYYKTLYSNISEVFPNDEMIMXXXXXXX 652
+A L TE+++L + +E M + I +Y L + N +++
Sbjct: 599 AIAGMFIECILKFTESKILPYDLNELMDDSIFEYLPKLEDRL-----NKTLMIGTKTDYL 653
Query: 653 XXXXXXXXXXXXXXXAMVDFVREQTQQDYPWWEWNKKLVILTRLISTNSKLRKLDRYFIT 712
+ + V+ + + + + N++L + ++ FI
Sbjct: 654 LDAQKQFKLLQKTVLELSEIVQRRNVSKLEELPFGSR-------VDINNRLIEFEKCFIN 706
Query: 713 DEGLKGRPFMKHSIFAPDKQTGYQGDVLPGLHEALLSENRQECIYWLETLLTQLDKISSL 772
G G P +H +F P Y GD + +H+ + + L L QL K +L
Sbjct: 707 PHGAIGNPQARHVLFHPSPDNWYDGDAISQVHDLISKISNSTDSKELGKLSRQLAKEIAL 766
Query: 773 LTI 775
+ +
Sbjct: 767 VNV 769
Score = 93.6 bits (231), Expect = 1e-18
Identities = 116/488 (23%), Positives = 192/488 (38%), Gaps = 99/488 (20%)
Query: 92 KSEAFRIY--VETLMKENKCQDHLSNYTSHIHWAGDAHAL---EYTINELSMLGF-TPKL 145
K +AF I + L+ +K + +L + T H AG + L E +++ G
Sbjct: 858 KFDAFSIANNIRQLINTDKIRSNLHSLTKKAHVAGTENNLRVAEIIRDQMISQGLENVHF 917
Query: 146 EEYHTWLNEPVKTE---VTLWDQN-HLLYNASMTEDYISEGEDNDSFKKVFGFHGFSANG 201
EY+ L+ P T V + ++N + Y + I E E ND ++ + +SA+G
Sbjct: 918 NEYNVLLSYPDWTTPNIVEILEENGDVFYKTTGRSISIIEEEQNDLVSEI-QWLAYSADG 976
Query: 202 TVRSEYVYCNYGTIEDYEHLLSHNVKLEGKIHVIRYGAIMKGIVVKNAETFGALGAILYT 261
TV + VY N GT +D EH+ S + L+ KI + RY + +G + + A GA +LY+
Sbjct: 977 TVEGDIVYVNKGTPKDIEHIESLGIDLKDKIVLARYSSNFRGNIAQMAVKKGAKACLLYS 1036
Query: 262 D-----SFDDGLIT-----ENNGYKPYPEGPARHESSIERGSVLLVDSVAGDPTTPEYSS 311
D S G I N P P A+ +L + + GD ++
Sbjct: 1037 DPMQVASLGTGPIVGWKKDPNYSLLPIPYSAAQ----------ILFEKMKGDAVIADFQG 1086
Query: 312 KHKDVKRLNSSSNLPTIPSVPMSEREIAPLLKLLNGNGIQWETKGNVKGFQYFSGPSDAG 371
K S+ P + + + ++ ++Y G +
Sbjct: 1087 CLK-------STFPPKLQVTFLGKLDVT---------------------YRYGPGLIN-N 1117
Query: 372 VSCRIVNEQKYLTKEITNVVIEIPGILK-EQEVIIGNHRDSWTXXXXXXXXXXXXILLEI 430
R+ K ++I NV+ I G + ++ V++GNH D+WT LLE+
Sbjct: 1118 QKLRVTVHAKNEERKIQNVLGYIKGSQEPDKFVLVGNHYDAWTYGAVDPNSVTST-LLEV 1176
Query: 431 ARGFSALHQ-KGWKP-----------------------------------LRTIKLISWD 454
R A GW+P R+I WD
Sbjct: 1177 TRALKAYQNLTGWRPGFRITSVIRKHFNMYTHVFNIITVTFTLVLKMGFLTRSILFAHWD 1236
Query: 455 GGEQGMLGSTEYGEYHRESLSKGTVAYFNLDLGVIGSKLNIKANPLLNELIVRSSKRTLF 514
E G++GSTE+ E HR L + VAY N D+ L ANP + ++R++ +
Sbjct: 1237 AEEYGLIGSTEFAEEHRTQLMRRAVAYINTDMIGGNQSLLAMANPTVVN-VLRAAAAKIS 1295
Query: 515 KEDPEVTL 522
+P+ L
Sbjct: 1296 HPNPKTFL 1303
>Hs4507455 [OPR] KOG2195 Transferrin receptor and related proteins containing
the protease-associated (PA) domain
Length = 780
Score = 130 bits (326), Expect = 1e-29
Identities = 116/427 (27%), Positives = 183/427 (42%), Gaps = 60/427 (14%)
Query: 197 FSANGTVRSEYVYCNYGTIEDYEHLLSHNVKLEGKIHVIRYGAIMKGIVVKNAETFGALG 256
+SA G V E VY +YG ED + L + V G++ ++R G I V NA+ FGA G
Sbjct: 235 YSAIGNVTGELVYAHYGRPEDLQDLRARGVDPVGRLLLVRVGVISFAQKVTNAQDFGAQG 294
Query: 257 AILYTDSFDDGLITENNGYKPYPEGPARHESSIERGSVLLVDSVAGDPTTPEYSSKHKDV 316
++Y + D + + P + S ++ V GDP TP + S ++
Sbjct: 295 VLIYPEPAD------------FSQDPPKPSLSSQQAVYGHVHLGTGDPYTPGFPSFNQTQ 342
Query: 317 KRLNSSSNLPTIPSVPMSEREIAPLLKLLNGNGIQWETKGNVKGFQYFSGPSDAGVSCRI 376
K L G E +G++ G Y GP G R+
Sbjct: 343 K---------------------------LKGPVAPQEWQGSLLGSPYHLGP---GPRLRL 372
Query: 377 VNEQKYLTKEITNVVIEIPGILK-EQEVIIGNHRDSWTXXXXXXXXXXXXILLEIARGFS 435
V + I N+ I G + + V+IG RD+W ILLE+ R FS
Sbjct: 373 VVNNHRTSTPINNIFGCIEGRSEPDHYVVIGAQRDAW-GPGAAKSAVGTAILLELVRTFS 431
Query: 436 ALHQKGWKPLRTIKLISWDGGEQGMLGSTEYGEYHRESLSKGTVAYFNLDLGVIG-SKLN 494
++ G++P R++ ISWDGG+ G +GSTE+ E + L V Y +LD V+G K +
Sbjct: 432 SMVSNGFRPRRSLLFISWDGGDFGSVGSTEWLEGYLSVLHLKAVVYVSLDNAVLGDDKFH 491
Query: 495 IKANPLLNELIVRSSKRTLFKEDPEVTLYDY-------WKESSNATIDILGAGTDFAVFQ 547
K +PLL LI K+ TLY+ W + + + F F
Sbjct: 492 AKTSPLLTSLIESVLKQVDSPNHSGQTLYEQVVFTNPSWDAEVIRPLPMDSSAYSFTAF- 550
Query: 548 NNLGIPSIDFSFDRDPKKDAVHQF-HSSYDSFEWMKTFVDPDF-SLHSTMAMFVGVSTLS 605
+G+P+++FSF D D + F H+ D++E + + ++ +A G +
Sbjct: 551 --VGVPAVEFSFMED---DQAYPFLHTKEDTYENLHKVLQGRLPAVAQAVAQLAGQLLIR 605
Query: 606 LTENELL 612
L+ + LL
Sbjct: 606 LSHDRLL 612
>Hs4507457 [OPR] KOG2195 Transferrin receptor and related proteins containing
the protease-associated (PA) domain
Length = 760
Score = 109 bits (272), Expect = 2e-23
Identities = 103/385 (26%), Positives = 168/385 (42%), Gaps = 57/385 (14%)
Query: 193 GFHGFSANGTVRSEYVYCNYGTIEDYEHLLSHNVKLEGKIHVIRYGAIMKGIVVKNAETF 252
G+ +S TV + V+ N+GT +D+E L + + G I ++R G I V NAE+
Sbjct: 218 GYVAYSKAATVTGKLVHANFGTKKDFEDLYT---PVNGSIVIVRAGKITFAEKVANAESL 274
Query: 253 GALGAILYTDSFDDGLITENNGYKPYPEGPARHESSIERGSVLLVDSVAGDPTTPEYSSK 312
A+G ++Y D ++ + + GDP TP + S
Sbjct: 275 NAIGVLIYMDQTKFPIVNAELSFFGHAH------------------LGTGDPYTPGFPSF 316
Query: 313 HKDVKRLNSSSNLPTIPSVPMSEREIAPLLKLLNGNGIQWETKGNVKGFQYFSGPSD--A 370
+ + SS LP IP +S L GN++G PSD
Sbjct: 317 NHTQFPPSRSSGLPNIPVQTISRAAAEKLF-------------GNMEG----DCPSDWKT 359
Query: 371 GVSCRIV-NEQKYLTKEITNVVIEIP-----GILK-----EQEVIIGNHRDSWTXXXXXX 419
+CR+V +E K + ++NV+ EI G++K + V++G RD+W
Sbjct: 360 DSTCRMVTSESKNVKLTVSNVLKEIKILNIFGVIKGFVEPDHYVVVGAQRDAW-GPGAAK 418
Query: 420 XXXXXXILLEIARGFSALHQK-GWKPLRTIKLISWDGGEQGMLGSTEYGEYHRESLSKGT 478
+LL++A+ FS + K G++P R+I SW G+ G +G+TE+ E + SL
Sbjct: 419 SGVGTALLLKLAQMFSDMVLKDGFQPSRSIIFASWSAGDFGSVGATEWLEGYLSSLHLKA 478
Query: 479 VAYFNLDLGVIG-SKLNIKANPLLNELIVRSSKRTLFKEDPEVTLYDYWKESSNATIDIL 537
Y NLD V+G S + A+PLL LI ++ + + P + Y + + ++ L
Sbjct: 479 FTYINLDKAVLGTSNFKVSASPLLYTLIEKTMQNV---KHPVTGQFLYQDSNWASKVEKL 535
Query: 538 GAGTDFAVFQNNLGIPSIDFSFDRD 562
F GIP++ F F D
Sbjct: 536 TLDNAAFPFLAYSGIPAVSFCFCED 560
>At4g07670 [OPR] KOG2195 Transferrin receptor and related proteins containing
the protease-associated (PA) domain
Length = 280
Score = 106 bits (265), Expect = 1e-22
Identities = 82/269 (30%), Positives = 125/269 (45%), Gaps = 44/269 (16%)
Query: 208 VYCNYGTIEDYEHLLSH-NVKLEGKIHVIRYGAIMKGIVVKNAETFGALGAILYTDSFDD 266
VY NYG +ED+ L V + G + + RYG I K +V NA GA+G ++YT+ D
Sbjct: 11 VYANYGRVEDFVRLKKDMGVNVSGAVVIARYGQIYKVDIVNNAYEAGAVGVVIYTNKRDY 70
Query: 267 GLITENNGYKPYPEGPARHESSIERGSVLLVDSVAGDPTTPEYSS----KHKDVKRLNSS 322
G G + +P S + G+V + GDPTTP ++S + + + S
Sbjct: 71 G------GDEWFPASKWMPPSGFQVGTVY---NGLGDPTTPGWASVDGCERLSDEAVELS 121
Query: 323 SNLPTIPSVPMSEREIAPLLKLLNGNGIQWETKGNVKGFQYFSGPSDAGVSCRIVNEQKY 382
++P IPS+P+S + +LK + G D G I+N Y
Sbjct: 122 GDVPLIPSLPVSAADAEVILKTIVG---------------------DVGPGPGILN-LSY 159
Query: 383 LTKEITNVVIEIPGILK-EQEVIIGNHRDSWTXXXXXXXXXXXXI-------LLEIARGF 434
+ +I NV+ I G + ++ VI+ NHRD+WT + L IA+
Sbjct: 160 IVTKIQNVIGVIEGEEEPDRYVILRNHRDTWTFRAVDPNSGTAVLMEASKSYLQHIAQRL 219
Query: 435 SALHQKGWKPLRTIKLISWDGGEQGMLGS 463
L ++GWKP RTI L +WD E G++ S
Sbjct: 220 DKLQKRGWKPRRTIILCNWDAEEYGLVSS 248
>Hs20470304 [OPR] KOG2195 Transferrin receptor and related proteins containing
the protease-associated (PA) domain
Length = 222
Score = 80.5 bits (197), Expect = 9e-15
Identities = 57/194 (29%), Positives = 94/194 (48%), Gaps = 12/194 (6%)
Query: 385 KEITNVVIEIPGILK-EQEVIIGNHRDSWTXXXXXXXXXXXXILLEIARGFSALHQKGWK 443
K +TNVV + G+ ++ +I+G+H + I+ R + ++GW+
Sbjct: 10 KTVTNVVGFVMGLTSPDRYIIVGSHHHTAHSYNGQEWASSTAIITAFIRALMSKVKRGWR 69
Query: 444 PLRTIKLISWDGGEQGMLGSTEYGEYHRESLSKGTVAYFNLDLGVIG-SKLNIKANPLLN 502
P RTI SW G G +GS E+GE ++ L K VAY +L + G S L A+P L
Sbjct: 70 PDRTIVFCSWGGTAFGNIGSYEWGEDFKKVLQKNVVAYISLHSPIRGNSSLYPVASPSLQ 129
Query: 503 ELIVRSSKRTLFKEDPEVTLYDYWKESSNATIDILGAGTDFAVFQNNLGIPSIDFSFDRD 562
+L+V K + T E++ ++I I G D F N+LG+P + F+++
Sbjct: 130 QLVVE-------KNNFNCTRRAQCPETNISSIQIQG---DADYFINHLGVPIVQFAYEDI 179
Query: 563 PKKDAVHQFHSSYD 576
+ V + H+S D
Sbjct: 180 KTLECVFRLHASTD 193
>YPL176c [OPR] KOG2195 Transferrin receptor and related proteins containing
the protease-associated (PA) domain
Length = 783
Score = 75.1 bits (183), Expect = 4e-13
Identities = 114/548 (20%), Positives = 212/548 (37%), Gaps = 74/548 (13%)
Query: 194 FHGFSANGTVRS-EYVYCNYGTIEDYEHLLSHNVKLEGKIHVIRYGAIMKGIVVKNAETF 252
F+ S NG + + +Y N +++D + + I ++ YG + ++ A+ +
Sbjct: 236 FNPMSHNGQLNNIPVIYANKASLDDMASMQDQGLLNGDFILLVHYGDYVFQQML-TAQEY 294
Query: 253 GALGAILYTDSFDDGLITENNGYKPYPEGPARHESSIERGSVLLVDSVAGDPTTPEYSSK 312
GA I ++ + D ++ I+ SV L GD TPE+
Sbjct: 295 GAKAIIFISEPYQD------------------NKDVIQMKSVALPQYGTGDALTPEWEGS 336
Query: 313 HKDVKRLNSSSNLPTIPSVPMSEREIAPLLKLLNGNGIQWETKGNVKGFQYFSGPSDAGV 372
+D + LP IPS+P+S + +L +L+ G+++ FSG +
Sbjct: 337 IRDPIDATEAKCLPKIPSIPISANQGDKILAILSDTGVKFSN-------NLFSGSLN--- 386
Query: 373 SCRIVNEQKYLTKE---ITNVVIEIPGILKE-QEVIIGNHRDSWTXXXXXXXXXXXXILL 428
CR+ + +E + ++V +I G + + ++I R+S + +L
Sbjct: 387 DCRLDLLVQTAIRERHPVHDIVGKIEGSEQAGRAIVIAAPRNSASYGTMYPSFGTVVLLS 446
Query: 429 EIARGFSALHQKGWKPLRTIKLISWDGGEQGMLGSTEYGEYHRESLSKGTVAYFNLDLGV 488
I +++ WKPLR I IS+ G E G+TE E E+L + Y +D+G
Sbjct: 447 LIQLYQEMVYKFDWKPLRNIYFISFGGSEFNEAGATELMEKRTEALK--SEIYTIIDVGQ 504
Query: 489 IG-----SKLNIKANPLLNELIVRSSKRTLFKEDPEVTLYDYWKESSNATIDILGAGTDF 543
IG + L I+ +PLL +L ++ F N +D + D+
Sbjct: 505 IGIWDDSNNLEIQCHPLLVDLFQKNMTSRKF----------------NVKVDNVHQFGDW 548
Query: 544 AVFQNNLGIPSIDFSFDRDPKKDAVHQFHSSYDSFEWMKTFV--DPDFSLHSTMAMFVGV 601
+ GIP S ++ H ++ D F+++K + + S + +++
Sbjct: 549 TPYLAQ-GIPVAIISSPGVMNRE--HPIYTVEDKFDFIKDKLRDKKKGEVLSEIMLYLVE 605
Query: 602 STLSLTENELLGFKTHEYMIEISKYYKTLYSNISEVFPNDEMIMXXXXXXXXXXXXXXXX 661
+L L ++ + F Y+ +S K L + DE+ +
Sbjct: 606 KSLELIDDPFIPFSISNYVDFLSTTLKDLQKECPDTVNFDEVFL------------GTTL 653
Query: 662 XXXXXXAMVDFVREQTQQDYPWWEWNKKLVILTRLISTNSKLRKLDRYFITDEGLKGRPF 721
+ E T+ Y + + +I S N L + +EGL R F
Sbjct: 654 WENTKLQFEKWKSEWTELMYGAGTYIEPTIIAINRWSWNYLLSLIGVTQCLEEGLMDRTF 713
Query: 722 MKHSIFAP 729
K+ IF P
Sbjct: 714 YKNVIFGP 721
>YOR256c [OPR] KOG2195 Transferrin receptor and related proteins containing
the protease-associated (PA) domain
Length = 809
Score = 62.8 bits (151), Expect = 2e-09
Identities = 125/576 (21%), Positives = 214/576 (36%), Gaps = 86/576 (14%)
Query: 178 YISEGEDNDSFKKVFGFHGFSANGTV-RSEYVYCNYGTIEDYEHLLSHNVKLEGKIHVI- 235
Y ++ E +D F+ S+NG + + +Y GT D +HL +GK +V+
Sbjct: 234 YDNKNEKHDLELSKENFNPLSSNGKLSKVSLIYGGKGTTYDLQHLKDSKTIEDGKDYVLL 293
Query: 236 -RYGAIMKGIVVKNAETFGALGAILYTDSFDDGLITENN---GYKPYPEGPARHESSIER 291
+Y ++ V+ AE FGA I ++ + + + + G Y G A
Sbjct: 294 LQYDKLVSQQVLI-AEKFGAKAVIFISEPYGENIDVVQSKPVGLPQYSTGDA-------- 344
Query: 292 GSVLLVDSVAGDPTTPEYSSKHKDVKRLNSSSNLPTIPSVPMSEREIAPLLKLLNGNGIQ 351
S L D +P HK ++ + IP++P+S R+ LL L+ G+
Sbjct: 345 -SGLNWDG------SPVEEKDHKFWRQTH-------IPTIPISTRQGKELLSRLSSGGVT 390
Query: 352 WETKGNVKGFQYFSGPSDAGVSCRIVNEQKYLTKEITNVVIEIPGILKEQEVIIGNHRDS 411
+ + + G V + +K+ I N+V +I G + + II +
Sbjct: 391 VDDGNSDRSNSGKMGDVLIDVDLQTNVREKHF---IPNIVGKIEGREQSDKAIIIAASRN 447
Query: 412 WTXXXXXXXXXXXXILLEIARGFSALHQK-GWKPLRTIKLISWDGGEQGMLGSTEYGEYH 470
LL I + F + K GWKPLR I IS+ G E GS+E E
Sbjct: 448 SINFGTTYPNFGTAALLSIVQLFQEVKYKFGWKPLRNIYFISFGGTEFNYAGSSELVEQR 507
Query: 471 RESLSKGTVAYFNLDLGVIG-------------SKLNIKANPLLNELIVRSSKRTLFKED 517
L Y +D+ +G +L+I+ +PLL + R++
Sbjct: 508 LTPLK--DEIYSLIDISQLGIPFAEKYENGKTRGELSIETHPLLKKFFNRNAHGNF---- 561
Query: 518 PEVTLYDYWKESSNATIDILGAGTDFAVFQNNLGIPSIDFSFDRDPKKDAVHQFHSSYDS 577
+ ++D + D+ F N GIP S D +D + +S D
Sbjct: 562 -------------DISVDNVQHYGDWTPFLAN-GIPVSVISSDSTRNRDTPTE--TSEDK 605
Query: 578 FEWMKTFVDPDFSLHSTMAMFVGVSTLS--LTENELLGFKTHEYMIEISKYYKTLYSNIS 635
FE ++ ++ + + S + V + +S L ++ LL F Y+ +I + + L
Sbjct: 606 FERVEKILEDEQNQQSVKDLLVYLLHISMELIDDPLLHFDIISYVEDIDERLQRLEQAYP 665
Query: 636 EVFPNDEMI--MXXXXXXXXXXXXXXXXXXXXXXAMVDFVREQTQQDYPWWEWNKKLVIL 693
E +I + + D + E + W WNKKL
Sbjct: 666 EKLNFTSIIKGLLFWKKIGSEWASWTQGWENIVWSHGDGI-EPSLLSINRWTWNKKLT-- 722
Query: 694 TRLISTNSKLRKLDRYFITDEGLKGRPFMKHSIFAP 729
+ R + GL R F K+ +F P
Sbjct: 723 -----------NIGRRTCSPAGLPNRSFYKNVLFGP 747
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.317 0.136 0.403
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 46,473,484
Number of Sequences: 60738
Number of extensions: 2017918
Number of successful extensions: 4879
Number of sequences better than 1.0e-05: 16
Number of HSP's better than 0.0 without gapping: 12
Number of HSP's successfully gapped in prelim test: 4
Number of HSP's that attempted gapping in prelim test: 4784
Number of HSP's gapped (non-prelim): 29
length of query: 775
length of database: 30,389,216
effective HSP length: 114
effective length of query: 661
effective length of database: 23,465,084
effective search space: 15510420524
effective search space used: 15510420524
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)