ORF      STATUS       Function Best COG  Functional category                                          Pathways and functional systems
r_klactII1185 good I KOG2480 Lipid transport and metabolism 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase

Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= r_klactII1185 420306 417091 -1072
         (1072 letters)

Database: KOG eukaryal database 04/03 
           60,738 sequences; 30,389,216 total letters

Searching..................................................done

Color Key for Alignment Scores:   
Score E Sequences producing significant alignments: (bits) Value YML075c [I] KOG2480 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) red... 1254 0.0 YLR450w [I] KOG2480 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) red... 1149 0.0 SPCC162.09c [I] KOG2480 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA)... 702 0.0 Hs4557643 [I] KOG2480 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) r... 491 e-138 At1g76490 [I] KOG2480 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) r... 462 e-130 7301039 [I] KOG2480 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) red... 456 e-128 At2g17370 [I] KOG2480 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) r... 454 e-127 CE02598 [I] KOG2480 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) red... 367 e-101 ECU10g1720 [I] KOG2480 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) ... 226 2e-58 >YML075c [I] KOG2480 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase Length = 1054 Score = 1254 bits (3246), Expect = 0.0 Identities = 640/1078 (59%), Positives = 796/1078 (73%), Gaps = 30/1078 (2%) Query: 1 MPLLFKELKYVVKPFANLAKFSAKHPIHVILISLLIAATTYLSVIEHYFNGWSVESRGLL 60 MP LFK LK + KP A +++FSAK PIH+IL SL+I+A YLSVI++YFNGW ++S + Sbjct: 1 MPPLFKGLKQMAKPIAYVSRFSAKRPIHIILFSLIISAFAYLSVIQYYFNGWQLDSNSVF 60 Query: 61 SYQGSLSSNSVEDDCTHYHFTPETAQWTEVSYEDVEKLRYQSIPIDHYYLLPFEFHSNNK 120 + SN++ +C+HY+ W ++ + +L HYYLL F+S N+ Sbjct: 61 ETAPNKDSNTLFQECSHYYRDSSLDGWVSITAHEASELPAPH----HYYLLNLNFNSPNE 116 Query: 121 SLEWPKLEGSVYQNGSVEYLLKDEFNVSKTLKSEDETEWTLRAHRYKLHDVKIFVISVYQ 180 + P+L +V++ + +Y+L+++ +VSK + S D T+W LR+ R L DVK S+Y Sbjct: 117 TDSIPELANTVFEKDNTKYILQEDLSVSKEISSTDGTKWRLRSDRKSLFDVKTLAYSLYD 176 Query: 181 DLFNRINSAEPFDIFIVGTAYVAMAYTLISLFIEMRVTGSKFWIALAAVVNSGTAFFVAL 240 + A+PFD+ I+ TAY+ M YT+ LF +MR TGS FW++ + VVNS ++ F+AL Sbjct: 177 VFSENVTQADPFDVLIMVTAYLMMFYTIFGLFNDMRKTGSNFWLSASTVVNSASSLFLAL 236 Query: 241 YATQKICNKPVTALSLIEGVPFVVVIVGFKHKIKLAKYVVDQFKRFDVSQKVTTYQVVYD 300 Y TQ I K V+AL+L EG+PF+VV+VGFKHKIK+A+Y +++F+R +S+++TT ++V++ Sbjct: 237 YVTQCILGKEVSALTLFEGLPFIVVVVGFKHKIKIAQYALEKFERVGLSKRITTDEIVFE 296 Query: 301 AMLNEGQRLVQDHLLCLIAFGGCAVYASSLSALSNFCFFCAVLLGFDLFITSTFFAAVLA 360 ++ EG RL+QDHLLC+ AF GC++YA L L+NFC A +L F+L +T TF++A+LA Sbjct: 297 SVSEEGGRLIQDHLLCIFAFIGCSMYAHQLKTLTNFCILSAFILIFELILTPTFYSAILA 356 Query: 361 LKLEINIIHRATTIKQTLEEDGVVPSTAGIISDSETLKKNKILRSNTTLTLGKLLFVAGF 420 L+LE+N+IHR+T IKQTLEEDGVVPSTA IIS +E + L + + + KL + F Sbjct: 357 LRLEMNVIHRSTIIKQTLEEDGVVPSTARIISKAEKKSVSSFLNLSVVVIIMKLSVILLF 416 Query: 421 IFFNFYNFSARWTYETFATLYAKSTTTELPTFITS-VIPNKSKSVLISVAPSQFYEPTKA 479 +F NFYNF A W + F +LY LP FITS N + ++SV P +Y+P K+ Sbjct: 417 VFINFYNFGANWVNDAFNSLYFDKERVSLPDFITSNASENFKEQAIVSVTPLLYYKPIKS 476 Query: 480 YFQVEDNILSLIRYISIAIRDRFVSKVLIFSLVISASINVYLLNAARIHTELTANDIQKQ 539 Y ++ED +L L+R +S+AIRDRFVSK+++ +LV SA INVYLLNAARIHT TA+ + K Sbjct: 477 YQRIEDMVLLLLRNVSVAIRDRFVSKLVLSALVCSAVINVYLLNAARIHTSYTADQLVKT 536 Query: 540 RASKKSF-----KSHTVHNENQSPSSSASNETKVEKPAETVPXXXXXXXXXXXXXXXXXP 594 +KKSF K+ T N++ S S + + Sbjct: 537 EVTKKSFTAPVQKASTPVLTNKTVISG-SKVKSLSSAQSSSSGPSSSSEEDDSRDIESLD 595 Query: 595 TTVRSLEELVTELKDGKVKSLKNKEVVSLVVNNKLPLYALEKQLGDTTRAVVVRRKALAI 654 +R LEEL L G K LKNKEV +LV++ KLPLYALEK+LGDTTRAV VRRKAL+I Sbjct: 596 KKIRPLEELEALLSSGNTKQLKNKEVAALVIHGKLPLYALEKKLGDTTRAVAVRRKALSI 655 Query: 655 LADAPVLSTERLPYKHYDYDRVFGACCENVIGYMPLPVGVIGPLMIDGVYYHIPMATTEG 714 LA+APVL+++RLPYK+YDYDRVFGACCENVIGYMPLPVGVIGPL+IDG YHIPMATTEG Sbjct: 656 LAEAPVLASDRLPYKNYDYDRVFGACCENVIGYMPLPVGVIGPLVIDGTSYHIPMATTEG 715 Query: 715 CLVASAMRGCKAMNAGGGVQTVLTKDGMTRGPCVRFPSLARAGACKIWLDSEEGQNRVKK 774 CLVASAMRGCKA+NAGGG TVLTKDGMTRGP VRFP+L R+GACKIWLDSEEGQN +KK Sbjct: 716 CLVASAMRGCKAINAGGGATTVLTKDGMTRGPVVRFPTLKRSGACKIWLDSEEGQNAIKK 775 Query: 775 AFNSTSRFARLQHIQTALAGDLLFIRFRTTTGDAMGMNMISKGVEFSLKQMVEEFGWNDM 834 AFNSTSRFARLQHIQT LAGDLLF+RFRTTTGDAMGMNMISKGVE+SLKQMVEE+GW DM Sbjct: 776 AFNSTSRFARLQHIQTCLAGDLLFMRFRTTTGDAMGMNMISKGVEYSLKQMVEEYGWEDM 835 Query: 835 EIVSVSGNFCMDKKPAAINWIEGRGKSVVAEATIPGDVVRKVLKSDVKALVDLNISKNLI 894 E+VSVSGN+C DKKPAAINWIEGRGKSVVAEATIPGDVVRKVLKSDV ALV+LNI+KNL+ Sbjct: 836 EVVSVSGNYCTDKKPAAINWIEGRGKSVVAEATIPGDVVRKVLKSDVSALVELNIAKNLV 895 Query: 895 GSAMAGSVGGFNAHASNLVSAVFLALGQDPAQNVESSNCITLMKEVDGDLRISVSMPSIE 954 GSAMAGSVGGFNAHA+NLV+AVFLALGQDPAQNVESSNCITLMKEVDGDLRISVSMPSIE Sbjct: 896 GSAMAGSVGGFNAHAANLVTAVFLALGQDPAQNVESSNCITLMKEVDGDLRISVSMPSIE 955 Query: 955 VGTIGGGTILEPQGAMLDLLGVRGPHPTQPGNNARQLAKIVASAVMAGELSLCSALAAGH 1014 VGTIGGGT+LEPQGAMLDLLGVRGPH T PG NARQLA+IVA AV+AGELSLC+ALAAGH Sbjct: 956 VGTIGGGTVLEPQGAMLDLLGVRGPHATAPGTNARQLARIVACAVLAGELSLCAALAAGH 1015 Query: 1015 LVQSHMVHNRAKQPATDGSXXXXXXXXXXXXPLTNGKKPLTPEELKTLKEGSVICIKS 1072 LVQSHM HNR T + L ++ LK+GSV CIKS Sbjct: 1016 LVQSHMTHNRKPAEPTKPNN-------------------LDATDINRLKDGSVTCIKS 1054 >YLR450w [I] KOG2480 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase Length = 1045 Score = 1149 bits (2971), Expect = 0.0 Identities = 590/1035 (57%), Positives = 751/1035 (72%), Gaps = 11/1035 (1%) Query: 1 MPLLFKELKYVVKPFANLAKFSAKHPIHVILISLLIAATTYLSVIEHYFNGWSVESRGLL 60 M L K + ++VKPFA A+FSA++PIHVI++++L++A YLSV + Y N W ++S Sbjct: 1 MSLPLKTIVHLVKPFACTARFSARYPIHVIVVAVLLSAAAYLSVTQSYLNEWKLDSNQYS 60 Query: 61 SYQGSLSSNSVEDDCTHYHFTPETAQWTEVSYEDVEKLRYQSIPIDHYYLLPFEFHSNNK 120 +Y S+ + + + CTHY+ +P + W +S ++ + Y HYYL F S + Sbjct: 61 TYL-SIKPDELFEKCTHYYRSPVSDTWKLLSSKEAADI-YTPF---HYYLSTISFQSKDN 115 Query: 121 SLEWPKLEGSVYQNGSVEYLLKDEFNVSKTLKSEDETEWTLRAHRYKLHDVKIFVISVYQ 180 S P L+ +Y YLL +E + L SE+ T+W LR + + D+ ++ + Sbjct: 116 STTLPSLDDVIYSVDHTRYLLSEEPKIPTELVSENGTKWRLRNNSNFILDLHNIYRNMVK 175 Query: 181 DLFNRINSAEPFDIFIVGTAYVAMAYTLISLFIEMRVTGSKFWIALAAVVNSGTAFFVAL 240 N+ + + FD+FI+ AY+ + YTL LF +MR GSKFW++ +A+ NS A +++L Sbjct: 176 QFSNKTSEFDQFDLFIILAAYLTLFYTLCCLFNDMRKIGSKFWLSFSALSNSACALYLSL 235 Query: 241 YATQKICNKPVTALSLIEGVPFVVVIVGFKHKIKLAKYVVDQFKRFDVSQKVTTYQVVYD 300 Y T + KP + LSL+ G+PF+VVI+GFKHK++LA + + +F R + +K+T ++Y+ Sbjct: 236 YTTHSLLKKPASLLSLVIGLPFIVVIIGFKHKVRLAAFSLQKFHRISIDKKITVSNIIYE 295 Query: 301 AMLNEGQRLVQDHLLCLIAFGGCAVYASSLSALSNFCFFCAVLLGFDLFITSTFFAAVLA 360 AM EG L++D+L + +F GCA+YA L L NFC +L FDL +++TF++A+L+ Sbjct: 296 AMFQEGAYLIRDYLFYISSFIGCAIYARHLPGLVNFCILSTFMLVFDLLLSATFYSAILS 355 Query: 361 LKLEINIIHRATTIKQTLEEDGVVPSTAGIISDSETLKKNKILRSNTTLTLGKLLFVAGF 420 +KLEINIIHR+T I+QTLEEDGVVP+TA II ET + LRSN + LGK + Sbjct: 356 MKLEINIIHRSTVIRQTLEEDGVVPTTADIIYKDETASEPHFLRSNVAIILGKASVIGLL 415 Query: 421 IFFNFYNFSARWTYETFATLYAKSTTTELPTFIT-SVIPNKSKSVLISVAPSQFYEPTKA 479 + N Y F+ + T+Y ST LP FI I N S V+ISV P Q+Y P K Sbjct: 416 LLINLYVFTDKLNATILNTVYFDSTIYSLPNFINYKDIGNLSNQVIISVLPKQYYTPLKK 475 Query: 480 YFQVEDNILSLIRYISIAIRDRFVSKVLIFSLVISASINVYLLNAARIHTELTANDIQKQ 539 Y Q+ED++L +I +S AIRD+F+SK+L F+ +S SINVYLLNAA+IHT Q Sbjct: 476 YHQIEDSVLLIIDSVSNAIRDQFISKLLFFAFAVSISINVYLLNAAKIHTGYMNFQPQSN 535 Query: 540 RASKKSF--KSHTVH-NENQSPSSSASNETKVEKPAETVPXXXXXXXXXXXXXXXXXPTT 596 + KS T+ +E +S +S+ ET V A+ + Sbjct: 536 KIDDLVVQQKSATIEFSETRSMPASSGLETPVT--AKDIIISEEIQNNECVYALSSQDEP 593 Query: 597 VRSLEELVTELKDGKVKSLKNKEVVSLVVNNKLPLYALEKQLGDTTRAVVVRRKALAILA 656 +R L LV ++ ++K++ N EV +LVVN KLPLY+LEK+L DTTRAV+VRRKAL+ LA Sbjct: 594 IRPLSNLVELMEKEQLKNMNNTEVSNLVVNGKLPLYSLEKKLEDTTRAVLVRRKALSTLA 653 Query: 657 DAPVLSTERLPYKHYDYDRVFGACCENVIGYMPLPVGVIGPLMIDGVYYHIPMATTEGCL 716 ++P+L +E+LP+++YDYDRVFGACCENVIGYMP+PVGVIGPL+IDG YHIPMATTEGCL Sbjct: 654 ESPILVSEKLPFRNYDYDRVFGACCENVIGYMPIPVGVIGPLIIDGTSYHIPMATTEGCL 713 Query: 717 VASAMRGCKAMNAGGGVQTVLTKDGMTRGPCVRFPSLARAGACKIWLDSEEGQNRVKKAF 776 VASAMRGCKA+NAGGG TVLTKDGMTRGP VRFP+L R+GACKIWLDSEEGQN +KKAF Sbjct: 714 VASAMRGCKAINAGGGATTVLTKDGMTRGPVVRFPTLIRSGACKIWLDSEEGQNSIKKAF 773 Query: 777 NSTSRFARLQHIQTALAGDLLFIRFRTTTGDAMGMNMISKGVEFSLKQMVEEFGWNDMEI 836 NSTSRFARLQHIQT LAGDLLF+RFRTTTGDAMGMNMISKGVE+SLKQMVEE+GW DME+ Sbjct: 774 NSTSRFARLQHIQTCLAGDLLFMRFRTTTGDAMGMNMISKGVEYSLKQMVEEYGWEDMEV 833 Query: 837 VSVSGNFCMDKKPAAINWIEGRGKSVVAEATIPGDVVRKVLKSDVKALVDLNISKNLIGS 896 VSVSGN+C DKKPAAINWIEGRGKSVVAEATIPGDVV+ VLKSDV ALV+LNISKNL+GS Sbjct: 834 VSVSGNYCTDKKPAAINWIEGRGKSVVAEATIPGDVVKSVLKSDVSALVELNISKNLVGS 893 Query: 897 AMAGSVGGFNAHASNLVSAVFLALGQDPAQNVESSNCITLMKEVDGDLRISVSMPSIEVG 956 AMAGSVGGFNAHA+NLV+A+FLALGQDPAQNVESSNCITLMKEVDGDLRISVSMPSIEVG Sbjct: 894 AMAGSVGGFNAHAANLVTALFLALGQDPAQNVESSNCITLMKEVDGDLRISVSMPSIEVG 953 Query: 957 TIGGGTILEPQGAMLDLLGVRGPHPTQPGNNARQLAKIVASAVMAGELSLCSALAAGHLV 1016 TIGGGT+LEPQGAMLDLLGVRGPHPT+PG NARQLA+I+A AV+AGELSLCSALAAGHLV Sbjct: 954 TIGGGTVLEPQGAMLDLLGVRGPHPTEPGANARQLARIIACAVLAGELSLCSALAAGHLV 1013 Query: 1017 QSHMVHNRAKQPATD 1031 QSHM HNR A + Sbjct: 1014 QSHMTHNRKTNKANE 1028 >SPCC162.09c [I] KOG2480 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase Length = 1053 Score = 702 bits (1811), Expect = 0.0 Identities = 408/878 (46%), Positives = 553/878 (62%), Gaps = 67/878 (7%) Query: 187 NSAEPFDIFIVGTAYVAMAYTLISLFIEMRVTGSKFWIALAAVVNSGTAFFVALYATQ-K 245 + A ++ IVGTAY M +++SL+++MR GSKFW+ + +++ T F V T + Sbjct: 198 SQASKTELLIVGTAYACMLISIVSLYLKMRRLGSKFWLFFSVLLS--TLFSVQFAMTLVR 255 Query: 246 ICNKPVTALSLIEGVPFVVVIVGFKHKIKLAKYVVDQFKRFDVSQKVTTYQVVYDAMLNE 305 ++ +SLIE +PF++ +V +L + V+ + D + ++ + A N Sbjct: 256 ASGVRISLVSLIESLPFLINVVALDKAAELTRQVITRCSVSDSHSPM--HEDIAKACRNA 313 Query: 306 GQRLVQDHLLCLIAFGGCAVYASSLSALSNFCFFCAVLLGFDLFITSTFFAAVLALKLEI 365 +++ ++ A+++ + F F AV++ +DL + +FF A+L LKLE+ Sbjct: 314 APPILRHFSFGIVVL---AIFSYCNFGIKQFFLFAAVMI-YDLLLLFSFFVAILTLKLEM 369 Query: 366 NIIHRATTIKQTLEEDGVVPSTAGIISDSETLKKNKILRSNT-TLTLGKLLFVAGFIFFN 424 + +++ L E+G+ STA ++D S + G + + FI FN Sbjct: 370 RRYNAKDDVRKVLIEEGLSESTARHVADGNDSSATTSAGSRYFKVRYGTKIILFIFIAFN 429 Query: 425 FYNFSARWTYETFATLYAKS-----TTTELPTF-------------ITSVIPNKS--KSV 464 + + AT A + ++ P F + S I + S +S Sbjct: 430 LFELCSIPFKHYAATSAAAARLIPLVRSQYPDFKSQRLLDDGVFDDVLSAISSMSNIESP 489 Query: 465 LISVAPSQFYEPTKAYFQVEDNILSLIRYISIAIRDRFVSKVLIFSLVISASINVYLLNA 524 + + P+ FY + I S I S I F+SK ++ +L +S ++NV+LLNA Sbjct: 490 SVRLLPAVFYGAELSSTSFLSTIHSFINNWSHYISASFLSKWIVCALSLSIAVNVFLLNA 549 Query: 525 ARIHTELTANDIQKQRASKKSFKSHTVHNENQSPSSSASNETKVEKPAETVPXXXXXXXX 584 AR+ N I+++ +K V PSS++S+ ++K Sbjct: 550 ARL------NSIKEE--PEKKVVEKVVEVVKYIPSSNSSSIDDIQKDE------------ 589 Query: 585 XXXXXXXXXPTTVRSLEELVTELKDGKVKSLKNKEVVSLVVNNKLPLYALEKQLGDTTRA 644 + VRSLEE +T +G++ +L ++EVV L + K+PLYALE+ L D TRA Sbjct: 590 ------IAQESVVRSLEECITLYNNGQISTLNDEEVVQLTLAKKIPLYALERVLKDVTRA 643 Query: 645 VVVRRKALAILADAPVLSTERLPYKHYDYDRVFGACCENVIGYMPLPVGVIGPLMIDGVY 704 VV+RR ++ + L + P HYDY RV ACCENVIGYMPLP+GV GPL+IDG Sbjct: 644 VVIRRTVVSRSSRTKTLESSNCPVYHYDYSRVLNACCENVIGYMPLPLGVAGPLIIDGKP 703 Query: 705 YHIPMATTEGCLVASAMRGCKAMNAGGGVQTVLTKDGMTRGPCVRFPSLARAGACKIWLD 764 ++IPMATTEG LVAS MRGCKA+NAGGG TVLT+D M+RGPCV FP+L RAG KIWLD Sbjct: 704 FYIPMATTEGALVASTMRGCKAINAGGGAVTVLTRDQMSRGPCVAFPNLTRAGRAKIWLD 763 Query: 765 SEEGQNRVKKAFNSTSRFARLQHIQTALAGDLLFIRFRTTTGDAMGMNMISKGVEFSLKQ 824 S EGQ +KKAFNSTSRFARLQHI+TALAG LFIRF T+TGDAMGMNMISKGVE +L Sbjct: 764 SPEGQEVMKKAFNSTSRFARLQHIKTALAGTRLFIRFCTSTGDAMGMNMISKGVEHALVV 823 Query: 825 MVEEFGWNDMEIVSVSGNFCMDKKPAAINWIEGRGKSVVAEATIPGDVVRKVLKSDVKAL 884 M + G++DM+++SVSGN+C DKKPAAINWI+GRGKSV+AEA IPGD V+ VLK+ V+ L Sbjct: 824 MSNDAGFDDMQVISVSGNYCTDKKPAAINWIDGRGKSVIAEAIIPGDAVKSVLKTTVEDL 883 Query: 885 VDLNISKNLIGSAMAGSVGGFNAHASNLVSAVFLALGQDPAQNVESSNCITLMKEVDGDL 944 V LN+ KNLIGSAMAGSVGGFNAHA+N+V+AV+LA GQDPAQNVESSNCITLM VDG+L Sbjct: 884 VKLNVDKNLIGSAMAGSVGGFNAHAANIVTAVYLATGQDPAQNVESSNCITLMDNVDGNL 943 Query: 945 RISVSMPSIEVGTIGGGTILEPQGAMLDLLGVRGPHPTQPGNNARQLAKIVASAVMAGEL 1004 ++SVSMPSIEVGTIGGGT+LEPQGAMLDLLGVRG H T PG+N+RQLA++VA+AVMAGEL Sbjct: 944 QLSVSMPSIEVGTIGGGTVLEPQGAMLDLLGVRGAHMTSPGDNSRQLARVVAAAVMAGEL 1003 Query: 1005 SLCSALAAGHLVQSHMVHNR-----------AKQPATD 1031 SLCSALA+GHLV+SH+ NR AK+PATD Sbjct: 1004 SLCSALASGHLVKSHIGLNRSALNTPAMDSSAKKPATD 1041 >Hs4557643 [I] KOG2480 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase Length = 888 Score = 491 bits (1264), Expect = e-138 Identities = 326/856 (38%), Positives = 470/856 (54%), Gaps = 68/856 (7%) Query: 194 IFIVGTAYVAMAYTLISLFIEMRVTGSKFWIALAAVVNSGTAFFVALYATQKICNKPVTA 253 I + T +A+ Y F +R GSK+ + +A + ++F + + +K +T Sbjct: 63 IILTITRCIAILYIYFQ-FQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFL-DKELTG 120 Query: 254 LSLIEGVPFVVVIVGFKHKIKLAKYVVDQFKRFDVSQKVTTYQVVYDAMLNEGQRLVQDH 313 L+ E +PF ++++ LAK+ + + +V + + + G D Sbjct: 121 LN--EALPFFLLLIDLSRASTLAKFALSSNSQDEVRENIARGMAIL------GPTFTLDA 172 Query: 314 LL-CLIAFGGCAVYASSLSALSNFCFFCAVLLGFDLFITSTFFAAVLALKLEINIIHRAT 372 L+ CL+ G L + CF C +L + F+ TFF A ++L LE++ R Sbjct: 173 LVECLVIGVGTMSGVRQLEIMC--CFGCMSVLA-NYFVFMTFFPACVSLVLELSRESREG 229 Query: 373 TIKQTLEEDGVVPSTAGIISDSETLKKNKILRSNTTLTLGKLLFVAGFIFFNFYNFSARW 432 L A ++ + E R ++LG +L A +RW Sbjct: 230 RPIWQLSH------FARVLEEEENKPNPVTQRVKMIMSLGLVLVHA----------HSRW 273 Query: 433 TYETFATLYAKSTTTELPTFITSVIPNKSKSVLISVAPSQFYEPTKAYFQVEDNILSLIR 492 A +++T + + N SK + SV+ QFY +E +++L Sbjct: 274 ----IADPSPQNSTADTSKVSLGLDENVSKRIEPSVSLWQFYLSKMISMDIEQ-VITLSL 328 Query: 493 YISIAIRDRFVSKVLIFS-LVISASINVYLLNAARIHTELTANDIQKQRASKKSFKSHTV 551 + +A++ F + S L + I ++ ++ + R ++K Sbjct: 329 ALLLAVKYIFFEQTETESTLSLKNPITSPVVTQKKVPDNCCRREPMLVRNNQKC------ 382 Query: 552 HNENQSPSSSASNETKVE--KP--AET-VPXXXXXXXXXXXXXXXXX-----------PT 595 ++ + + E KVE KP AET P P Sbjct: 383 --DSVEEETGINRERKVEVIKPLVAETDTPNRATFVVGNSSLLDTSSVLVTQEPEIELPR 440 Query: 596 TVRSLEELVTELKDGK--VKSLKNKEVVSLVVNNKLPLYALEKQLGDTTRAVVVRRKALA 653 R EE + L + + K L + E++ LV +P Y LE + R V +RR+ L+ Sbjct: 441 EPRPNEECLQILGNAEKGAKFLSDAEIIQLVNAKHIPAYKLETLMETHERGVSIRRQLLS 500 Query: 654 ILADAPVLSTERLPYKHYDYDRVFGACCENVIGYMPLPVGVIGPLMIDGVYYHIPMATTE 713 P S + LPY+ Y+Y V GACCENVIGYMP+PVGV GPL +D + +PMATTE Sbjct: 501 KKLSEPS-SLQYLPYRDYNYSLVMGACCENVIGYMPIPVGVAGPLCLDEKEFQVPMATTE 559 Query: 714 GCLVASAMRGCKAMNAGGGVQTVLTKDGMTRGPCVRFPSLARAGACKIWLDSEEGQNRVK 773 GCLVAS RGC+A+ GGG + + DGMTRGP VR P + K WL++ EG +K Sbjct: 560 GCLVASTNRGCRAIGLGGGASSRVLADGMTRGPVVRLPRACDSAEVKAWLETSEGFAVIK 619 Query: 774 KAFNSTSRFARLQHIQTALAGDLLFIRFRTTTGDAMGMNMISKGVEFSLKQMVEEFGWND 833 +AF+STSRFARLQ + T++AG L+IRF++ +GDAMGMNMISKG E +L ++ E F + Sbjct: 620 EAFDSTSRFARLQKLHTSIAGRNLYIRFQSRSGDAMGMNMISKGTEKALSKLHEYF--PE 677 Query: 834 MEIVSVSGNFCMDKKPAAINWIEGRGKSVVAEATIPGDVVRKVLKSDVKALVDLNISKNL 893 M+I++VSGN+C DKKPAAINWIEGRGKSVV EA IP VVR+VLK+ +A++++NI+KNL Sbjct: 678 MQILAVSGNYCTDKKPAAINWIEGRGKSVVCEAVIPAKVVREVLKTTTEAMIEVNINKNL 737 Query: 894 IGSAMAGSVGGFNAHASNLVSAVFLALGQDPAQNVESSNCITLMK---EVDGDLRISVSM 950 +GSAMAGS+GG+NAHA+N+V+A+++A GQD AQNV SSNCITLM+ + DL IS +M Sbjct: 738 VGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITLMEASGPTNEDLYISCTM 797 Query: 951 PSIEVGTIGGGTILEPQGAMLDLLGVRGPHPTQPGNNARQLAKIVASAVMAGELSLCSAL 1010 PSIE+GT+GGGT L PQ A L +LGV+G PG NARQLA+IV VMAGELSL +AL Sbjct: 798 PSIEIGTVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLARIVCGTVMAGELSLMAAL 857 Query: 1011 AAGHLVQSHMVHNRAK 1026 AAGHLV+SHM+HNR+K Sbjct: 858 AAGHLVKSHMIHNRSK 873 >At1g76490 [I] KOG2480 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase Length = 592 Score = 462 bits (1190), Expect = e-130 Identities = 236/414 (57%), Positives = 307/414 (74%), Gaps = 7/414 (1%) Query: 616 KNKEVVSLVVNNKLPLYALEKQLGDTTRAVVVRRKALAILADAPVLSTERLPYKHYDYDR 675 +++E+V V++ +P Y+LE +LGD RA +RR+AL + S E LP +DY+ Sbjct: 171 EDEEIVKSVIDGVIPSYSLESRLGDCKRAASIRREALQRVTGR---SIEGLPLDGFDYES 227 Query: 676 VFGACCENVIGYMPLPVGVIGPLMIDGVYYHIPMATTEGCLVASAMRGCKAMNAGGGVQT 735 + G CCE +GY+ +PVG+ GPL++DG Y +PMATTEGCLVAS RGCKAM GG + Sbjct: 228 ILGQCCEMPVGYIQIPVGIAGPLLLDGYEYSVPMATTEGCLVASTNRGCKAMFISGGATS 287 Query: 736 VLTKDGMTRGPCVRFPSLARAGACKIWLDSEEGQNRVKKAFNSTSRFARLQHIQTALAGD 795 + KDGMTR P VRF S RA K +L++ E + + FN +SRFARLQ ++ +AG Sbjct: 288 TVLKDGMTRAPVVRFASARRASELKFFLENPENFDTLAVVFNRSSRFARLQSVKCTIAGK 347 Query: 796 LLFIRFRTTTGDAMGMNMISKGVEFSLKQMVEEFGWNDMEIVSVSGNFCMDKKPAAINWI 855 ++RF +TGDAMGMNM+SKGV+ L+ + ++F DM+++ +SGNFC DKKPAA+NWI Sbjct: 348 NAYVRFCCSTGDAMGMNMVSKGVQNVLEYLTDDF--PDMDVIGISGNFCSDKKPAAVNWI 405 Query: 856 EGRGKSVVAEATIPGDVVRKVLKSDVKALVDLNISKNLIGSAMAGSVGGFNAHASNLVSA 915 EGRGKSVV EA I G++V KVLK+ V ALV+LN+ KNL GSA+AGS+GGFNAHASN+VSA Sbjct: 406 EGRGKSVVCEAVIRGEIVNKVLKTSVAALVELNMLKNLAGSAVAGSLGGFNAHASNIVSA 465 Query: 916 VFLALGQDPAQNVESSNCITLMKEV-DG-DLRISVSMPSIEVGTIGGGTILEPQGAMLDL 973 VF+A GQDPAQNVESS CIT+M+ + DG D+ ISV+MPSIEVGT+GGGT L Q A L+L Sbjct: 466 VFIATGQDPAQNVESSQCITMMEAINDGKDIHISVTMPSIEVGTVGGGTQLASQSACLNL 525 Query: 974 LGVRGPHPTQPGNNARQLAKIVASAVMAGELSLCSALAAGHLVQSHMVHNRAKQ 1027 LGV+G PG NAR+LA IVA AV+AGELSL SA+AAG LV+SHM +NR+ + Sbjct: 526 LGVKGASTESPGMNARRLATIVAGAVLAGELSLMSAIAAGQLVRSHMKYNRSSR 579 >7301039 [I] KOG2480 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase Length = 920 Score = 456 bits (1173), Expect = e-128 Identities = 300/823 (36%), Positives = 464/823 (55%), Gaps = 58/823 (7%) Query: 212 FIEMRVTGSKFWIALAAVVNSGTAFFVALYATQKICNKPVTALSLIEGVPFVVVIVGFKH 271 F + GSK+ + +A + ++F A K ++ L + + F+++++ + Sbjct: 125 FCSLHRLGSKYVLGIAGLFTVFSSFIFTT-AIIKFLGSDISELK--DALFFLLLVIDLSN 181 Query: 272 KIKLAKYVVDQFKRFDVSQKVTTYQVVYDAMLNEGQRLVQDHLLCLIAFGGCAVYASSLS 331 +LA+ + + +V+Q + + G + D ++ ++ G + S + Sbjct: 182 SGRLAQLALSGSNQAEVTQNIARGLELL------GPAISLDTIVEVLLVGVGTL--SGVQ 233 Query: 332 ALSNFCFFCAVLLGFDLFITSTFFAAVLALKLEINIIHRATTIKQTLEEDGVVPSTAGII 391 L C F + + + + TF+ A L+L +++ R+ + E + ++ Sbjct: 234 RLEVLCMFAVLSVLVNYVVFMTFYPACLSLIFDLS---RSGVDMSVVREK----AKGSLL 286 Query: 392 SDSETLKKNKILRSNTTLTLGKLLFVAGFIFFNFYNFSARWTYETFATLYAKSTTTELPT 451 S T ++ K +N L KL+ G + + Y+ A + Y T PT Sbjct: 287 LKSLTEEEQK---ANPVLQRVKLIMTTGLMAVHIYSRVA-----FSGSDYDAVDKTLTPT 338 Query: 452 FITSVIPNKSKSVLISVAPSQFYEPTKAYFQVEDNILSLI-RYISIAIRDRFVSKVLIFS 510 +V N+++S I+ ++ + + + +++L+ ++I RD + Sbjct: 339 LSLNVSNNRTESGEIADIIIKWLTMSADHIVISIVLIALVVKFICFDNRDPLPDQ----- 393 Query: 511 LVISASINVYLLNAARIHTELTANDIQKQRASKKSFKSHTV--HNENQSPSSSASNETKV 568 + S V + A T + +++++ ++ S T+ E+QS S++AS +T Sbjct: 394 --LRQSGPVAIAAKASQTTPIDEEHVEQEKDTENSAAVRTLLFTIEDQS-SANASTQT-- 448 Query: 569 EKPAETVPXXXXXXXXXXXXXXXXXPTTVRSLEELVTELKDGK-VKSLKNKEVVSLVV-- 625 + +P P V+ +++ ++G +L ++E+VS+V Sbjct: 449 ----DLLPLRHRLVGPIKP------PRPVQECLDILNSTEEGSGPAALSDEEIVSIVHAG 498 Query: 626 NNKLPLYALEKQLGDTTRAVVVRRKALAILADAPVLSTERLPYKHYDYDRVFGACCENVI 685 PL+ +E L D R V +RR+ + A PV + LPY+H+DY +V ACCENV+ Sbjct: 499 GTHCPLHKIESVLDDPERGVRIRRQIIGSRAKMPVGRLDVLPYEHFDYRKVLNACCENVL 558 Query: 686 GYMPLPVGVIGPLMIDGVYYHIPMATTEGCLVASAMRGCKAMNAGGGVQTVLTKDGMTRG 745 GY+P+PVG GPL++DG Y++PMATTEG LVAS RGCKA++ G V++V+ GMTR Sbjct: 559 GYVPIPVGYAGPLLLDGETYYVPMATTEGALVASTNRGCKALSVRG-VRSVVEDVGMTRA 617 Query: 746 PCVRFPSLARAGACKIWLDSEEGQNRVKKAFNSTSRFARLQHIQTALAGDLLFIRFRTTT 805 PCVRFPS+ARA K W++++E VK F+STSRF RL+ A+ G L+IRF T Sbjct: 618 PCVRFPSVARAAEAKSWIENDENYRVVKTEFDSTSRFGRLKDCHIAMDGPQLYIRFVAIT 677 Query: 806 GDAMGMNMISKGVEFSLKQMVEEFGWNDMEIVSVSGNFCMDKKPAAINWIEGRGKSVVAE 865 GDAMGMNM+SKG E +L+++ +F DM+I+S+SGNFC DKKPAAINWI+GRGK VV E Sbjct: 678 GDAMGMNMVSKGAEMALRRIQLQFP--DMQIISLSGNFCCDKKPAAINWIKGRGKRVVTE 735 Query: 866 ATIPGDVVRKVLKSDVKALVDLNISKNLIGSAMAGSVGGFNAHASNLVSAVFLALGQDPA 925 TI +R VLK+D K LV+ N KN+ GSAMAGS+GG NAHA+N+V+AVFLA GQDPA Sbjct: 736 CTISAATLRSVLKTDAKTLVECNKLKNMGGSAMAGSIGGNNAHAANMVTAVFLATGQDPA 795 Query: 926 QNVESSNCITLMK---EVDGDLRISVSMPSIEVGTIGGGTILEPQGAMLDLLGVRGPHPT 982 QNV SSNC T M+ E DL ++ +MPS+EVGT+GGGT L Q A L++LGVRG H T Sbjct: 796 QNVTSSNCSTAMECWAENSEDLYMTCTMPSLEVGTVGGGTGLPGQSACLEMLGVRGAHAT 855 Query: 983 QPGNNARQLAKIVASAVMAGELSLCSALAAGHLVQSHMVHNRA 1025 +PG+NA++LA+IV + VMAGELSL +AL LV+SHM HNR+ Sbjct: 856 RPGDNAKKLAQIVCATVMAGELSLMAALVNSDLVKSHMRHNRS 898 >At2g17370 [I] KOG2480 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase Length = 562 Score = 454 bits (1168), Expect = e-127 Identities = 230/420 (54%), Positives = 307/420 (72%), Gaps = 5/420 (1%) Query: 608 KDGKVKSLKNKEVVSLVVNNKLPLYALEKQLGDTTRAVVVRRKALAILADAPVLSTERLP 667 ++ ++ S++++E+V LV++ +P Y+LE +LGD RA +RR+A+ + S LP Sbjct: 138 RESELDSVEDEEIVKLVIDGTIPSYSLETKLGDCKRAAAIRREAVQRITGK---SLTGLP 194 Query: 668 YKHYDYDRVFGACCENVIGYMPLPVGVIGPLMIDGVYYHIPMATTEGCLVASAMRGCKAM 727 + +DY+ + G CCE +GY+ +PVG+ GPL++DGV Y +PMATTEGCLVAS RG KA+ Sbjct: 195 LEGFDYNSILGQCCEMPVGYVQIPVGIAGPLLLDGVEYSVPMATTEGCLVASTNRGFKAI 254 Query: 728 NAGGGVQTVLTKDGMTRGPCVRFPSLARAGACKIWLDSEEGQNRVKKAFNSTSRFARLQH 787 + GG +VL KD MTR P VRFPS RA +L R+ FN +SRFARLQ Sbjct: 255 HLSGGAFSVLVKDAMTRAPVVRFPSARRAALVMFYLQDPSNFERLSLIFNKSSRFARLQS 314 Query: 788 IQTALAGDLLFIRFRTTTGDAMGMNMISKGVEFSLKQMVEEFGWNDMEIVSVSGNFCMDK 847 I +AG L+ RF +TGDAMGMNM+SKGV+ L + EF DM+++ +SGN+C DK Sbjct: 315 ITCTIAGRNLYPRFACSTGDAMGMNMVSKGVQNVLDFVKSEFP--DMDVIGISGNYCSDK 372 Query: 848 KPAAINWIEGRGKSVVAEATIPGDVVRKVLKSDVKALVDLNISKNLIGSAMAGSVGGFNA 907 K +A+NWIEGRGK VV EA I ++V KVLK+ V+ALV+LN KNL+GSAMAGS+GGFNA Sbjct: 373 KASAVNWIEGRGKHVVCEAFIKAEIVEKVLKTSVEALVELNTLKNLVGSAMAGSLGGFNA 432 Query: 908 HASNLVSAVFLALGQDPAQNVESSNCITLMKEVDGDLRISVSMPSIEVGTIGGGTILEPQ 967 H+SN+VSAVF+A GQDPAQNVESS+C+T++ DL ISVSMP IEVGT+GGGT L Q Sbjct: 433 HSSNIVSAVFIATGQDPAQNVESSHCMTMILPDGDDLHISVSMPCIEVGTVGGGTQLASQ 492 Query: 968 GAMLDLLGVRGPHPTQPGNNARQLAKIVASAVMAGELSLCSALAAGHLVQSHMVHNRAKQ 1027 A L+LLGV+G + +PG+NA+QLA+IVA +V+AGELSL SA+AAG LV+SHM +NR+ + Sbjct: 493 AACLNLLGVKGSNNEKPGSNAQQLARIVAGSVLAGELSLMSAIAAGQLVKSHMKYNRSSR 552 >CE02598 [I] KOG2480 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase Length = 608 Score = 367 bits (943), Expect = e-101 Identities = 203/432 (46%), Positives = 278/432 (63%), Gaps = 14/432 (3%) Query: 598 RSLEELVTELKDGKVKSLKNKEVVSLVVNNKLPLYALEKQLGDTTRAVVVRRKALAILAD 657 RSL+E+ E K+ K + E V L+ + LE + +A+ +RR + Sbjct: 142 RSLDEISREWKE--CKDVTPGEAVRLLRRGQAKSRELESRF-PAEQAIPIRRTFIN---- 194 Query: 658 APVLSTERLPYKHYDYDRVFGACCENVIGYMPLPVGVIGPLMIDGVY-YHIPMATTEGCL 716 E LPY YDY CCENVIGY P+PVGV GPL ++G ++PMATTEG L Sbjct: 195 ---KKFENLPYLGYDYTLATECCCENVIGYTPVPVGVAGPLTLNGTSEIYVPMATTEGAL 251 Query: 717 VASAMRGCKAMNAGGGVQTVLTKDGMTRGPCVRFPSLARAGACKIWLDSEEGQNRVKKAF 776 +AS RG + A GGV+T + GMTR P V+FP+ A + K WL+ E Q+R ++ F Sbjct: 252 IASTNRGMNVIRAAGGVETSIFNSGMTRAPVVKFPTARDAVSMKRWLEHPENQDRARQEF 311 Query: 777 NSTSRFARLQHIQTALAGDLLFIRFRTTTGDAMGMNMISKGVEFSLKQMVEEFGWNDMEI 836 S SRFA+L+ I + G+L ++RF TGDAMGMNMISK + +++ ++E F +M + Sbjct: 312 QSCSRFAKLKSIDITIDGNLAYLRFDAHTGDAMGMNMISKSCDSTMRFLMENF--PEMTV 369 Query: 837 VSVSGNFCMDKKPAAINWIEGRGKSVVAEATIPGDVVRKVLKSDVKALVDLNISKNLIGS 896 +++SGN C+DKK AA NW EGRG+SVVAE IP +VV K L++ + L L +K IGS Sbjct: 370 LALSGNLCVDKKAAAKNWTEGRGRSVVAECLIPREVVTKTLRTTPEQLAYLTTTKLHIGS 429 Query: 897 AMAGSVGGFNAHASNLVSAVFLALGQDPAQNVESSNCITLMK-EVDGDLRISVSMPSIEV 955 + AG+VGG NAHA+N+V+A+F+A GQD AQ V SS C T M+ D +L +S ++P +EV Sbjct: 430 SRAGAVGGSNAHAANIVAAIFIATGQDAAQVVSSSMCSTRMEVTADKNLYVSCTLPCVEV 489 Query: 956 GTIGGGTILEPQGAMLDLLGVRGPHPTQPGNNARQLAKIVASAVMAGELSLCSALAAGHL 1015 GT+GGGTIL PQ A L+ LG GP+ QPG NA +LA+++A+ V+AGELSL +AL L Sbjct: 490 GTVGGGTILAPQRACLESLGCAGPNKEQPGQNAERLAEVIAATVLAGELSLMAALTTNEL 549 Query: 1016 VQSHMVHNRAKQ 1027 V SHM NR+KQ Sbjct: 550 VSSHMKLNRSKQ 561 >ECU10g1720 [I] KOG2480 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase Length = 474 Score = 226 bits (575), Expect = 2e-58 Identities = 139/362 (38%), Positives = 208/362 (57%), Gaps = 13/362 (3%) Query: 672 DYDRVFGACCENVIGYMPLPVGVIGP-LMIDGVYYHIPMATTEGCLVASAMRGCKAMNAG 730 DY V CCEN+IGY +P+GV ++I+G + IP+ATTEG LVAS RG K +NA Sbjct: 111 DYSDVINRCCENLIGYKKVPLGVSNRGVLINGRMFFIPIATTEGALVASMCRGIKLINAC 170 Query: 731 GGVQTVLTKDGMTRGPCVRFPSLARAGACKIWLDSEEGQNRVKKAFNSTSRFARLQHIQT 790 GGV+ G+TRG +RF S A W+ +E +K+ N SR+ ++ I++ Sbjct: 171 GGVKGYAENVGITRGFIMRFESFEEAMRFYQWIKMDEAVEDLKRIGNEGSRYMKISKIES 230 Query: 791 A-LAGDLLFIRFRTTTGDAMGMNMISKGVEFSLKQMVEEFGWNDMEIVSVSGNFCMDKKP 849 + G+ ++++ +GDAMGMNMI+K ++ F + +V +S N C DKK Sbjct: 231 KHVVGEDVYVKVYGYSGDAMGMNMITKACTQISAEISRRFPHS--SLVCISSNTCTDKKW 288 Query: 850 AAINWIEGRGKSVVAEATIPGDVVRKVLKSDVKALVDLNISKNLIGSAMAGSVGGFNAHA 909 +A N+ GRG+ + I R++L ++ ++D+ +K +IG ++ +GGFN A Sbjct: 289 SAENYCNGRGRRIFMNMKIDDKSCREILGVGIRQVLDVYHAKVVIGGSLV--LGGFNCQA 346 Query: 910 SNLVSAVFLALGQDPAQNVESSNCITLMK-EVDGDLRISVSMPSIEVGTIGGGTILEPQG 968 +N V+ +FLALGQD Q +ESSNC+ MK DGDL +S+ MPS+ VG IGGGT LEP Sbjct: 347 ANYVAGMFLALGQDLGQVIESSNCVLSMKRSTDGDLSVSLFMPSVVVGVIGGGTHLEPSK 406 Query: 969 AML-DLLGVRGPHPTQPGNNARQLAK-----IVASAVMAGELSLCSALAAGHLVQSHMVH 1022 + L G + ++ + LA V +AV+ GELSL +LA L++SH+ Sbjct: 407 SFLKQFYSGSGEYIITNRDDDKSLAPGYLGLAVGAAVLGGELSLLGSLANNTLMESHLRL 466 Query: 1023 NR 1024 NR Sbjct: 467 NR 468 Database: KOG eukaryal database 04/03 Posted date: Apr 14, 2003 1:07 PM Number of letters in database: 30,389,216 Number of sequences in database: 60,738 Lambda K H 0.320 0.135 0.387 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 58,354,718 Number of Sequences: 60738 Number of extensions: 2381691 Number of successful extensions: 6393 Number of sequences better than 1.0e-05: 9 Number of HSP's better than 0.0 without gapping: 9 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 6345 Number of HSP's gapped (non-prelim): 15 length of query: 1072 length of database: 30,389,216 effective HSP length: 117 effective length of query: 955 effective length of database: 23,282,870 effective search space: 22235140850 effective search space used: 22235140850 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits)