ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactII1328 good R KOG2968 General function prediction only Predicted esterase of the alpha-beta hydrolase superfamily (Neuropathy target esterase), contains cAMP-binding domains
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactII1328 474790 470468 -1441
(1441 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YML059c [R] KOG2968 Predicted esterase of the alpha-beta hydrola... 1206 0.0
SPCC4B3.04c [R] KOG2968 Predicted esterase of the alpha-beta hyd... 610 e-174
Hs5729951 [R] KOG2968 Predicted esterase of the alpha-beta hydro... 399 e-110
7290863 [R] KOG2968 Predicted esterase of the alpha-beta hydrola... 387 e-107
CE25687 [R] KOG2968 Predicted esterase of the alpha-beta hydrola... 375 e-103
CE29641 [R] KOG2968 Predicted esterase of the alpha-beta hydrola... 369 e-101
Hs20537616 [R] KOG2968 Predicted esterase of the alpha-beta hydr... 360 9e-99
CE03510 [R] KOG2968 Predicted esterase of the alpha-beta hydrola... 262 3e-69
ECU05g0070 [R] KOG2968 Predicted esterase of the alpha-beta hydr... 229 2e-59
>YML059c [R] KOG2968 Predicted esterase of the alpha-beta hydrolase
superfamily (Neuropathy target esterase) contains
cAMP-binding domains
Length = 1679
Score = 1206 bits (3121), Expect = 0.0
Identities = 729/1610 (45%), Positives = 939/1610 (58%), Gaps = 265/1610 (16%)
Query: 43 LRTRILSNYSQLKDDV---------SDENNINRKDYMDASS----------ASFLLNREK 83
++ RILS Y +L + NIN A++ AS +++ +K
Sbjct: 124 MKERILSQYKRLTPEFLPLENTGKSGSSANINAASTQSANAPPAIGSSTTGASSIIDSKK 183
Query: 84 HK---------GFTSYLDEFLSAIKIFGYLEKPVFHELTKSMKTEKLQEGEIVLLDDSVG 134
H +SYLD+FLSAIKIFGYLEKPVFH+LTK+MKT+K+ EGEI+LLD ++G
Sbjct: 184 HSLKDGNENETFLSSYLDQFLSAIKIFGYLEKPVFHDLTKNMKTQKMDEGEILLLDSTIG 243
Query: 135 FTIVVEGTLEILHKMDNR---------HSNPSGDAAANATAFEPPSNDD----------- 174
F IVVEGTL++ H++D+ HS+ G + + +DD
Sbjct: 244 FAIVVEGTLQLYHEVDHSDKDHGDETDHSDTDGLDDQDRDEEDEEEDDDIDNYDTKSCSS 303
Query: 175 ----------GY--LING-EKFQLLNIVKTGNPLSSLVSIMKLFSNRSTHLNEGTHPSTT 221
GY L NG FQLLN VK GNPL+SLVSI+ LF T
Sbjct: 304 NLIDEEDESVGYIHLKNGLGNFQLLNTVKPGNPLTSLVSILNLF---------------T 348
Query: 222 NNTPGPGSPNLTGEINSFLDSTLPAKFGSADSANGNHPISPMELESTFDNLSEASENDRS 281
++ G+ N E++S +D+T+ S E F N + + S
Sbjct: 349 HSMSSYGNSNFPSELSSPIDTTVSVNNMFCSS------------EQNFSNTDSMTNSTNS 396
Query: 282 -----AKIPDIIARAASDCTIAIIPSSSFQRLLVKYPRSASHIIQMILTKLYRVTFKTAH 336
+ +P ++ARAA+DCTI IIP SF +L KYPRSASHIIQM+LTKLY VTF+TAH
Sbjct: 397 FPTFPSSMPKLVARAATDCTIGIIPPQSFAKLTAKYPRSASHIIQMVLTKLYHVTFQTAH 456
Query: 337 TYLGLTNEIIFTEFQSINKDNLKLPEYFRRSIISYFTNRQDDTGSS-----------AST 385
YLGLT EI+ E +LP Y + ++I F +GS+ +S
Sbjct: 457 DYLGLTKEIMDIEVLLNKSIVYELPYYLKEAVIRKFKTVDKSSGSADLEPKPKNSNASSK 516
Query: 386 IQKRPQLHRRD---------------SNNSLNY--------GSRHVVLNSRDQYNPG--- 419
++K P+ D S+NSL+ SRHVVL SRDQ+NPG
Sbjct: 517 LKKPPKAKPSDGIIQSLKIANANANTSSNSLSLKPEFTHHPSSRHVVLGSRDQFNPGDLL 576
Query: 420 ---------DLLSNVPLPR-------------------------------------LNPQ 433
D+LS P+ L+P+
Sbjct: 577 SNVPLSRTMDILSPNPIHNNNRNKSNGINTSTSNQHKRSSRSSSNNASVHSKKFSSLSPE 636
Query: 434 QRN----------------DXXXXXXXXXXXRADYRPIIL--NNFSSSQFEETEVSSWRL 475
RN D R RP +L +FS++Q EETE S+ R+
Sbjct: 637 LRNAQLSTSPLSLDNTSVHDHIHPSPVHLKGRVSPRPNLLPTTSFSAAQ-EETEDSALRM 695
Query: 476 ALVEIIFQQLGITKDTIEPPIXXXXXXXXXXXXEKGLVRRXXXXXXXXXXXXXXXXXXNH 535
ALVE + LG+ K + + +
Sbjct: 696 ALVEAMLTYLGVNKSNMSVSSSSIANMSSLNSPQLNEMYSRRPSNASFLMSPHCTPSDIS 755
Query: 536 LVTFLPRESQQFSRLNRTGGKMASHSKRLNGSSRSNSRTDRSESFDHFRNENLGGDNQFS 595
+ + Q + L + +KR N S + + R+ + NL
Sbjct: 756 VASSFASPQTQPTMLRILPKEYTISNKRHNKSKSQDKKKPRA--YKEELTPNL------- 806
Query: 596 DFESVKEDFSKCIKILKFEEGETILCQNSNPQGIYYLVSGEVDVISETKD---------- 645
DFE VK+DF++ I++ F++G TI+ QN+ +G++Y++SG+V+V + +
Sbjct: 807 DFEDVKKDFAQGIQLKFFKKGTTIVEQNARGKGLFYIISGKVNVTTNSSSSVVSSMSKPE 866
Query: 646 ---------GNTDESYERTLYTATEGYILGYLSSILGCKSLVTLKVSKGPAYLGLIPYND 696
G + LY+ G I+GYLSS++G KS V + V+K Y+G +
Sbjct: 867 QVSAQSSHKGENPHHTQHLLYSVGSGGIVGYLSSLIGYKSFVNI-VAKSDVYVGFLSSAT 925
Query: 697 LERLCDKYFMIYLKLSEILTNSLSPNLLRLDYFLEWIQLDSSETLFNQGDPANGVYLVLN 756
LERL DKYF+IYL++S+ LT LS LL+LD+ LEW+ L +SETLF+QGD ANG+Y+VLN
Sbjct: 926 LERLFDKYFLIYLRISDSLTKLLSSRLLKLDHALEWVHLRASETLFSQGDSANGIYVVLN 985
Query: 757 GRLRQLFYED------ADSDIVTQ---MAELSKGESFGEVEVLTAIHRLNTVVAIRDTEL 807
GRLRQL + + ++ TQ + EL++GESFGEVEVLTA++R +T+VA+RD+EL
Sbjct: 986 GRLRQLQQQSLSNSNTSSEEVETQNIILGELAQGESFGEVEVLTAMNRYSTIVAVRDSEL 1045
Query: 808 ARIPRTLFEFLAVEHPSIMIHVSRMVAKKAMLMNFKSGIGFSGSQPITKLIGDETAMQKR 867
ARIPRTLFE LA+EHPSIMI VSR+VAKK + G + + L GD ++ K
Sbjct: 1046 ARIPRTLFELLALEHPSIMIRVSRLVAKKIV-----------GDRTVPALTGDPLSI-KE 1093
Query: 868 YDFXXXXXXXXXXXXXXXX-------XXTVNYKTLTLLPITEGLPVEEFAYKLINALRQC 920
DF T+ ++T+T+LPIT GLPVE FA KL+ A +Q
Sbjct: 1094 NDFTSLIPPTKASYSSSLSHKPQNITSGTITFRTITILPITSGLPVEAFAMKLVQAFKQV 1153
Query: 921 GKTTIGLNQRTTLSHLGRHAFNKLSKLKQSGYFAELEELYEIVVYIADTPVSSSWTQTCI 980
G+TTIGLNQRTTL+HLGRHAF++LSKLKQSGYFAELEE+Y+ VVYI+DTPV S+WT+TCI
Sbjct: 1154 GRTTIGLNQRTTLTHLGRHAFDRLSKLKQSGYFAELEEMYQTVVYISDTPVKSNWTRTCI 1213
Query: 981 SQGDCILLLADATC-DPKIGEFERLLLKSKTTARTDLILLHPERYVVPGSTSKWLKNRMW 1039
+QGDCILLLADA +IGE+E+LLL SKTTART+LILLHPERYV PG T KWL+ R W
Sbjct: 1214 AQGDCILLLADARSPSAEIGEYEKLLLNSKTTARTELILLHPERYVEPGLTHKWLRYRPW 1273
Query: 1040 IQSHHHIQF----TPMEKVAEPDPIPN--IKPLSQLVEKFKENTKKTQENFVKFLPDSIK 1093
+ SHHHIQF T + + + N + + +L++ E ++KTQ+N K LPDSIK
Sbjct: 1274 VHSHHHIQFSLTGTTLMNEGKMHVLNNGALALMDKLIQT--EFSRKTQQNISKLLPDSIK 1331
Query: 1094 TTVETLSGKYIDPKPNPKFYTSVDPIKNDFLRLARTXXXXXXXXXXXXXXXXXXXXXXII 1153
TVE S +++ K ++YT V KNDFLRLAR +I
Sbjct: 1332 NTVENFSSRFM--KSKRQYYTPVHRHKNDFLRLARILSGQAIGLVLGGGGARGISHLGVI 1389
Query: 1154 KALEEQGIPIDIIGGTSIGSFVGGLYAMDYDLVPIYGRVKKFAGRVGSLWRMLSDLTWPV 1213
+A+EEQGIP+D+IGGTSIGSFVGGLYA DYDLVPIYGRVKKFAGR+ S+WRML+DLTWPV
Sbjct: 1390 QAIEEQGIPVDVIGGTSIGSFVGGLYAKDYDLVPIYGRVKKFAGRISSIWRMLTDLTWPV 1449
Query: 1214 TSYTTGHEFNRGIWKSFRDYRIEDFWISYYCNSTNITESVQEIHSSGFAWRYIRASMSLA 1273
TSYTTGHEFNRGIWK+F D RIEDFWI YYCNSTNIT+SVQEIHS G+AWRYIRASMSLA
Sbjct: 1450 TSYTTGHEFNRGIWKTFGDTRIEDFWIQYYCNSTNITDSVQEIHSFGYAWRYIRASMSLA 1509
Query: 1274 GLLPPIVDNGNMLLDGGYVDNLPVTEMTQRGCKIVFAVDVGSVDDRTPMSYGDSLNGFWI 1333
GLLPP+ +NG+MLLDGGYVDNLPVTEM RGC+ +FAVDVGS DDRTPM YGDSLNGFWI
Sbjct: 1510 GLLPPLEENGSMLLDGGYVDNLPVTEMRARGCQTIFAVDVGSADDRTPMEYGDSLNGFWI 1569
Query: 1334 VLNRWNPFSKHPNIPNMAEIQMRLGYVASVNALERAKSTPGVVYIRPPIENYATLDFGKF 1393
+ NRWNPFS HPNIPNMAEIQ+RLGYVASVNALE+AK+TPGVVY+RPPIE YATLDF KF
Sbjct: 1570 IFNRWNPFSSHPNIPNMAEIQVRLGYVASVNALEKAKNTPGVVYVRPPIEEYATLDFSKF 1629
Query: 1394 EEIYQVGYAYGHDFLQHLQEKNELPPIAGT--TTSAYADKENMLQRRNSI 1441
EEIY VG YG FLQ L + +++P I G+ TT E +L RRNSI
Sbjct: 1630 EEIYHVGVDYGRIFLQGLIDDDKMPYIPGSQETTLNSQVPEFLLHRRNSI 1679
>SPCC4B3.04c [R] KOG2968 Predicted esterase of the alpha-beta hydrolase
superfamily (Neuropathy target esterase) contains
cAMP-binding domains
Length = 1316
Score = 610 bits (1572), Expect = e-174
Identities = 336/851 (39%), Positives = 505/851 (58%), Gaps = 73/851 (8%)
Query: 603 DFSKCIKILKFEEGETILCQNSNPQGIYYLVSGEVDVISETKDGNTDESYERTL----YT 658
+F+K I+I+ +++G TI+ Q + G+YY++ G +D +K SY+ L +
Sbjct: 527 EFAKEIEIIFYKKGTTIVRQGDHADGLYYIIDGFLDATCPSKL-TFSTSYDTDLGMHSFM 585
Query: 659 ATEGYILGYLSSILGCKSLVTLKVSKGPAYLGLIPYNDLERLCDKYFMIYLKLSEILTNS 718
G I+ Y + + +S + + ++ +G +P + LER+ D+ +I L +++ L +
Sbjct: 586 IKPGGIVNYQACVSNYRSFINV-TARSDVLVGFLPRSCLERIIDQEPLISLTIAKRLISL 644
Query: 719 LSPNLLRLDYFLEWIQLDSSETLFNQGDPANGVYLVLNGRLRQLFYEDADSDIVTQMA-- 776
+ LL+LD+ + WI L+ + ++ + DP++ VY+VLNGRLR + ED TQ+
Sbjct: 645 VPSLLLKLDFAVGWIHLNPDQVVYEKNDPSDCVYVVLNGRLRSI--EDERGSARTQVDYF 702
Query: 777 -ELSKGESFGEVEVLTAIHRLNTVVAIRDTELARIPRTLFEFLAVEHPSIMIHVSRMVAK 835
E KG+S GE+E+L R +T+ AIRD+ELA+IP TLF L++ HP++ + +S+++A
Sbjct: 703 NEYGKGDSVGELEMLLNNRRSSTLFAIRDSELAKIPETLFNALSLSHPAVGLQLSKIIAN 762
Query: 836 KA-MLMNFKSGIGFSGSQPITKLIGDETAMQKRYDFXXXXXXXXXXXXXXXXXXTVNYKT 894
+ +L+N KS G QP K + +T
Sbjct: 763 RMNLLLNNKSMDGMQ-HQPHEKH---------------------------------SIRT 788
Query: 895 LTLLPITEGLPVEEFAYKLINALRQCGKTTIGLNQRTTLSHLGRHAFNKLSKLKQSGYFA 954
L ++P + + F+ KL + L GK+ L Q + L HLG+HAF+++ + K S Y +
Sbjct: 789 LAIVPSSSTGLLILFSQKLTSVLSVMGKSVKVLRQSSVLEHLGKHAFSRMGRFKLSSYLS 848
Query: 955 ELEELYEIVVYIADTPVSSSWTQTCISQGDCILLLADATCDPKIGEFERLLLKSKTTART 1014
+LE+ Y+I++Y+AD+ V S+W QTCI Q DCI +LA+A +P IGE+E+ L+ K+TAR
Sbjct: 849 DLEDKYDILIYVADSGVGSAWLQTCIRQADCIYILAEADQNPNIGEYEQHLIAMKSTARK 908
Query: 1015 DLILLHPERYVVPGSTSKWLKNRMWIQSHHHIQFTPMEKVAEPDPIPNIKPLSQLVEKFK 1074
+L+LLHPER+ G T WLK R W+ +HHH+Q +
Sbjct: 909 ELVLLHPERFCPSGLTRLWLKERPWVYAHHHVQL-----------------------RIG 945
Query: 1075 ENTKKTQENFVKFLPDSIKTTVETLS---GKYIDPKPNPKFYTSVDPIKNDFLRLARTXX 1131
+ + +Q N K + I+ V+ L KYID K Y + +DF RLAR
Sbjct: 946 LDNEISQNNEAKVFLNIIRAKVQNLHYGFRKYIDWKHLHPVYQANRAQDSDFARLARRIC 1005
Query: 1132 XXXXXXXXXXXXXXXXXXXXIIKALEEQGIPIDIIGGTSIGSFVGGLYAMDYDLVPIYGR 1191
I+ ALEE GIP DIIGGTSIG+F GGLYA + DLVP++GR
Sbjct: 1006 GKAIALVLGGGGARGISQIGILYALEEAGIPFDIIGGTSIGAFNGGLYAWEADLVPMFGR 1065
Query: 1192 VKKFAGRVGSLWRMLSDLTWPVTSYTTGHEFNRGIWKSFRDYRIEDFWISYYCNSTNITE 1251
KKF GR+ +LWR + D+T+P +YTTGHEFNRGIWK+F + IEDFW+ +Y N+TNIT
Sbjct: 1066 AKKFCGRMANLWRFVLDVTYPQAAYTTGHEFNRGIWKTFGEIHIEDFWLPFYANTTNITH 1125
Query: 1252 SVQEIHSSGFAWRYIRASMSLAGLLPPIV-DNGNMLLDGGYVDNLPVTEMTQRGCKIVFA 1310
S +IHSSG+AWRYIRASMSLAGL+PP++ D+G+MLLDGGY+DNL V+ M G +FA
Sbjct: 1126 SRMDIHSSGYAWRYIRASMSLAGLVPPMLSDSGDMLLDGGYMDNLTVSHMQSLGASSIFA 1185
Query: 1311 VDVGSVDDRTPMSYGDSLNGFWIVLNRWNPFSKHPNIPNMAEIQMRLGYVASVNALERAK 1370
+DVGS D R PM YGD+++G W +++RW PF + P++AEIQ RL YV SV E+ K
Sbjct: 1186 IDVGSEDSREPMHYGDTVSGVWALISRWIPFIPKTSFPSLAEIQSRLTYVTSVATGEKVK 1245
Query: 1371 STPGVVYIRPPIENYATLDFGKFEEIYQVGYAYGHDFLQHLQEKNELPPIAGTTTSAYAD 1430
S PG Y+RPP++++ TL+FG FE+IY VGY YG ++++ L+ ++L I ++
Sbjct: 1246 SMPGCFYMRPPVKDFPTLEFGSFEKIYNVGYNYGKEYVEKLKTSHKLDDILSPRDTSKRH 1305
Query: 1431 KENMLQRRNSI 1441
+ + RRNS+
Sbjct: 1306 PKFLSSRRNSL 1316
Score = 144 bits (362), Expect = 1e-33
Identities = 120/418 (28%), Positives = 186/418 (43%), Gaps = 77/418 (18%)
Query: 82 EKHKGFTSYLDEFLSAIKIFGYLEKPVFHELTKSMKTEKLQEGEIVLLDDSVGFTIVVEG 141
E GF +YLDEFLSAI IFGYLEKPVF EL + ++T+++ EG + L + F +VV+G
Sbjct: 114 EPRIGFQNYLDEFLSAISIFGYLEKPVFVELARHIRTQRVAEGNTIYLGEQSSFILVVDG 173
Query: 142 TLEILHKMDNRHSNPSGDAAANATAFEPPSNDDGYLINGEKFQLLNIVKTGNPLSSLVSI 201
++ + P D+A P +++LL V G PLSS ++
Sbjct: 174 CFQVF-------TAPEKDSAEVVEEAGQP-----------EYRLLTEVSNGAPLSSFFTV 215
Query: 202 MKLFSNRSTHLNEGTHP-STTNNTPGPGSPNLTGEINSFLDSTLPAKFGSADSANGNHPI 260
++LF+ +P +T ++ PGS T A + N + P
Sbjct: 216 LELFTELIPEATSKENPFKSTTSSLRPGSSTTT----------------EAGANNASKPH 259
Query: 261 SPMELESTFDNLSEASENDRSAKIPDIIARAASDCTIAIIPSSSFQRLLVKYPRSASHII 320
P ++ IIA+A D TIA+IP+++F L+ K+P S++ I+
Sbjct: 260 MPQPKKAR------------------IIAKAKIDTTIAVIPANAFHHLVHKFPNSSAQIV 301
Query: 321 QMILTKLYRVTFKTAHTYLGLTNEIIFTEFQSINKDNLKLPEYFRRSIISYFTNRQDDTG 380
Q+ILT+ RVTF T + YLGL++ I E + +LP Y R II F
Sbjct: 302 QVILTRFQRVTFSTGYEYLGLSDAIFSIEKNFNSLTAYELPNYIRSDIIDDFKKEAMSEH 361
Query: 381 SSASTIQKRPQLHRRDSNNSLN-------YGSRH---VVLNSRDQYNPGDLLSNVPLPRL 430
S ++ + L + + + L+ + H V R N GDLLS+
Sbjct: 362 LSQASNESFIVLRSKGAQSRLSNQYFSKAFDKEHGNFVSDIDRSTANAGDLLSST----- 416
Query: 431 NPQQRNDXXXXXXXXXXXRADYRPIILNNFSSSQFEETEVS-SWRLALVEIIFQQLGI 487
NP R LN S + + ++S S+R L++ IF+ LG+
Sbjct: 417 NPH--------STLLSTSVGPLRKFPLNRSYSREVGDYDISASFRDGLLQCIFKSLGV 466
>Hs5729951 [R] KOG2968 Predicted esterase of the alpha-beta hydrolase
superfamily (Neuropathy target esterase) contains
cAMP-binding domains
Length = 1327
Score = 399 bits (1025), Expect = e-110
Identities = 257/836 (30%), Positives = 414/836 (48%), Gaps = 104/836 (12%)
Query: 590 GDNQFSDFESVKEDFSKCIKI-----------LKFEEGETILC-QNSNPQGIYYLVSGEV 637
G S FE+ K++ +K ++I L + TI+ Q +++++ G +
Sbjct: 450 GRQTSSIFEAAKQELAKLMRIEDPSLLNSRVLLHHAKAGTIIARQGDQDVSLHFVLWGCL 509
Query: 638 DVISETKDGNTDESYERTLYTATEGYILGYLSSILGCKSLVTLKVSKGPAYLGLIPYNDL 697
V D++ + L+ A G ++G L+ + G + TL+ + +L I +D
Sbjct: 510 HVYQRM----IDKAEDVCLFVAQPGELVGQLAVLTGEPLIFTLRAQRDCTFLR-ISKSDF 564
Query: 698 ERLCDKYFMIYLKLSEILTNSLSPNLLRLDYFLEWIQLDSSETLFNQGDPANGVYLVLNG 757
+ + L + + +SP + ++D+ ++W +++ L+ QGD ++ Y+VLNG
Sbjct: 565 YEIMRAQPSVVLSAAHTVAARMSPFVRQMDFAIDWTAVEAGRALYRQGDRSDCTYIVLNG 624
Query: 758 RLRQLFYEDADSDIVTQMAELSKGESFGEVEVLTAIHRLNTVVAIRDTELARIPRTLFEF 817
RLR + + + + E +G+ G VE LT R TV A+RDTELA++P
Sbjct: 625 RLRSVIQRGSGKKEL--VGEYGRGDLIGVVEALTRQPRATTVHAVRDTELAKLPEGTLGH 682
Query: 818 LAVEHPSIMIHVSRMVAKKAMLMN-------FKSGIGFSGSQPITKLIGDETAMQKRYDF 870
+ +P ++ + ++++K +L N F +G G G P ++L +
Sbjct: 683 IKRRYPQVVTRLIHLLSQK-ILGNLQQLQGPFPAGSGL-GVPPHSELTNPAS-------- 732
Query: 871 XXXXXXXXXXXXXXXXXXTVNYKTLTLLPITEGLPVEEFAYKLINALRQCGKTTIGLNQR 930
N T+ +LP+ +P+ F +L +AL+ G T + LN
Sbjct: 733 --------------------NLATVAILPVCAEVPMVAFTLELQHALQAIGPTLL-LNSD 771
Query: 931 TTLSHLGRHAFNKLSKLKQSGYFAELEELYEIVVYIADTPVSSSWTQTCISQGDCILLLA 990
+ LG A + + + + SG+ A+ E+ + IV+Y D ++ WT C+ Q DCIL++
Sbjct: 772 IIRARLGASALDSIQEFRLSGWLAQQEDAHRIVLYQTDASLTP-WTVRCLRQADCILIVG 830
Query: 991 DATCDPKIGEFERLLLKSKTTARTDLILLHPERYVVPGSTSKWLKNRMWIQSHHHIQFTP 1050
+P +G+ E++L + A L+LLH E P T +WL R W H H++ P
Sbjct: 831 LGDQEPTLGQLEQMLENTAVRALKQLVLLHREEGAGPTRTVEWLNMRSWCSGHLHLR-CP 889
Query: 1051 MEKVAEPDPIPNIKPLSQLVEKFKENTKKTQENFVKFLPDSIKTTVETLSGKYIDPKPNP 1110
+ P L +L EK
Sbjct: 890 RRLFSRRSPAK----LHELYEKV------------------------------------- 908
Query: 1111 KFYTSVDPIKNDFLRLARTXXXXXXXXXXXXXXXXXXXXXXIIKALEEQGIPIDIIGGTS 1170
F D +DF RLAR ++KALEE G+P+D++GGTS
Sbjct: 909 -FSRRADR-HSDFSRLARVLTGNTIALVLGGGGARGCSHIGVLKALEEAGVPVDLVGGTS 966
Query: 1171 IGSFVGGLYAMDYDLVPIYGRVKKFAGRVGSLWRMLSDLTWPVTSYTTGHEFNRGIWKSF 1230
IGSF+G LYA + R +++A + S+ + DLT+PVTS TG FNR I + F
Sbjct: 967 IGSFIGALYAEERSASRTKQRAREWAKSMTSVLEPVLDLTYPVTSMFTGSAFNRSIHRVF 1026
Query: 1231 RDYRIEDFWISYYCNSTNITESVQEIHSSGFAWRYIRASMSLAGLLPPIVD--NGNMLLD 1288
+D +IED W+ Y+ +T+IT S +H G WRY+RASM+L+G LPP+ D +G++L+D
Sbjct: 1027 QDKQIEDLWLPYFNVTTDITASAMRVHKDGSLWRYVRASMTLSGYLPPLCDPKDGHLLMD 1086
Query: 1289 GGYVDNLPVTEMTQRGCKIVFAVDVGSVDDRTPMSYGDSLNGFWIVLNRWNPFSKHPNIP 1348
GGY++NLP G K V A+DVGS D+ +YGDSL+G+W++ R NP++ +P
Sbjct: 1087 GGYINNLPADIARSMGAKTVIAIDVGSQDETDLSTYGDSLSGWWLLWKRLNPWADKVKVP 1146
Query: 1349 NMAEIQMRLGYVASVNALERAKSTPGVVYIRPPIENYATLDFGKFEEIYQVGYAYG 1404
+MAEIQ RL YV+ V LE KS+ Y+RPPI+ + T+DFGKF++IY VGY YG
Sbjct: 1147 DMAEIQSRLAYVSCVRQLEVVKSSSYCEYLRPPIDCFKTMDFGKFDQIYDVGYQYG 1202
Score = 63.9 bits (154), Expect = 2e-09
Identities = 29/67 (43%), Positives = 41/67 (60%)
Query: 287 IIARAASDCTIAIIPSSSFQRLLVKYPRSASHIIQMILTKLYRVTFKTAHTYLGLTNEII 346
+ ARAA D T+ +P +F + KYP S ++Q+I+ +L RVTF H YLGLTNE+
Sbjct: 235 VSARAARDSTVLRLPVEAFSAVFTKYPESLVRVVQIIMVRLQRVTFLALHNYLGLTNELF 294
Query: 347 FTEFQSI 353
E Q +
Sbjct: 295 SHEIQPL 301
>7290863 [R] KOG2968 Predicted esterase of the alpha-beta hydrolase
superfamily (Neuropathy target esterase) contains
cAMP-binding domains
Length = 1389
Score = 387 bits (994), Expect = e-107
Identities = 234/817 (28%), Positives = 412/817 (49%), Gaps = 86/817 (10%)
Query: 608 IKILKFEEGETILCQ-NSNPQGIYYLVSGEVDVISETKDGNT--DESYERTLYTATEGYI 664
+++ + E T++ + N++ ++++++G + V +D + + ++ G I
Sbjct: 461 VELRELEPNVTLITEGNADDVCVWFVMTGTLAVYQSNQDATRAKQDKSDMLIHFVHPGEI 520
Query: 665 LGYLSSILGCKSLVTLKVSKGPAYLGLIPYNDLERLCDKYFMIYLKLSEILTNSLSPNLL 724
+G L+ + G S T++ S+ + I + ++ + I L L + LSP +
Sbjct: 521 VGGLAMLTGEASAYTIR-SRSITRIAFIRRAAIYQIMRQRPRIVLDLGNGVVRRLSPLVR 579
Query: 725 RLDYFLEWIQLDSSETLFNQGDPANGVYLVLNGRLRQLFYEDADSDIVTQMAELSKGESF 784
+ DY L+WI L+S ++ Q + ++ Y+VL+GR+R + + + E KG+
Sbjct: 580 QCDYALDWIFLESGRAVYRQDESSDSTYIVLSGRMRSVITHPGGKKEI--VGEYGKGDLV 637
Query: 785 GEVEVLTAIHRLNTVVAIRDTELARIPRTLFEFLAVEHPSIMIHVSRMVAKKAM-LMNFK 843
G VE++T R TV+A+RD+ELA++P LF + + +P ++ + ++ + + M +
Sbjct: 638 GIVEMITETSRTTTVMAVRDSELAKLPEGLFNAIKLRYPIVVTKLISFLSHRFLGSMQTR 697
Query: 844 SGIGFSGSQPITKLIGDETAMQKRYDFXXXXXXXXXXXXXXXXXXTVNYKTLTLLPITEG 903
SG G G+ + T Y T+ L+PIT+
Sbjct: 698 SGSGAPGAPVEANPV------------------------------THKYSTVALVPITDE 727
Query: 904 LPVEEFAYKLINALRQCGKTTIGLNQRTTLSHLGRHAFNKLSKLKQSGYFAELEELYEIV 963
+P+ F Y+L ++L G + L LG + F ++ + + + A+ E+ I
Sbjct: 728 VPMTPFTYELYHSLCAIGPV-LRLTSDVVRKQLGSNIFEAANEYRLTSWLAQQEDRNIIT 786
Query: 964 VYIADTPVSSSWTQTCISQGDCILLLADATCDPKIGEFERLLLKSKTTARTDLILLHPER 1023
+Y D+ +S+ WTQ C+ Q D IL++ +G+FER + + + +L+LL+PE
Sbjct: 787 LYQCDSSLSA-WTQRCMRQADVILIVGLGDRSHLVGKFEREIDRLAMRTQKELVLLYPEA 845
Query: 1024 Y-VVPGSTSKWLKNRMWIQSHHHIQFTPMEKVAEPDPIPNIKPLSQLVEKFKENTKKTQE 1082
P +T WL R W+ HHH+ + T+K+Q
Sbjct: 846 SNAKPANTLSWLNARPWVTKHHHVLCVK-----------------------RIFTRKSQY 882
Query: 1083 NFVKFLPDSIKTTVETLSGKYIDPKPNPKFYTSVDPIKNDFLRLARTXXXXXXXXXXXXX 1142
+ L + + +PN + +DF RLAR
Sbjct: 883 R------------INDLYSRVLLSEPN---------MHSDFSRLARWLTGNSIGLVLGGG 921
Query: 1143 XXXXXXXXXIIKALEEQGIPIDIIGGTSIGSFVGGLYAMDYDLVPIYGRVKKFAGRVGSL 1202
++KA++E GIP+D++GG SIG+ +G L+ + ++ + + ++++ ++
Sbjct: 922 GARGAAHIGMLKAIQEAGIPVDMVGGVSIGALMGALWCSERNITTVTQKAREWSKKMTKW 981
Query: 1203 WRMLSDLTWPVTSYTTGHEFNRGIWKSFRDYRIEDFWISYYCNSTNITESVQEIHSSGFA 1262
+ L DLT+P+TS +G EFN+ I +F D IED WI Y+ +T+IT S IH++G
Sbjct: 982 FLQLLDLTYPITSMFSGREFNKTIHDTFGDVSIEDLWIPYFTLTTDITASCHRIHTNGSL 1041
Query: 1263 WRYIRASMSLAGLLPPIVD--NGNMLLDGGYVDNLPVTEMTQRGCKIVFAVDVGSVDDRT 1320
WRY+R+SMSL+G +PP+ D +G++LLDGGYV+NLP M G + A+DVGS DD
Sbjct: 1042 WRYVRSSMSLSGYMPPLCDPKDGHLLLDGGYVNNLPADVMHNLGAAHIIAIDVGSQDDTD 1101
Query: 1321 PMSYGDSLNGFWIVLNRWNPFSKHPNIPNMAEIQMRLGYVASVNALERAKSTPGVVYIRP 1380
+YGD L+G+W++ +WNPF+ +P++ +IQ RL YV+ V LE K++ YIRP
Sbjct: 1102 LTNYGDDLSGWWLLYKKWNPFTSPVKVPDLPDIQSRLAYVSCVRQLEEVKNSDYCEYIRP 1161
Query: 1381 PIENYATLDFGKFEEIYQVGYAYGHDFLQHLQEKNEL 1417
PI+ Y TL FG F+EI VGY +G ++ + + + L
Sbjct: 1162 PIDKYKTLAFGSFDEIRDVGYVFGKNYFESMAKAGRL 1198
>CE25687 [R] KOG2968 Predicted esterase of the alpha-beta hydrolase
superfamily (Neuropathy target esterase) contains
cAMP-binding domains
Length = 1360
Score = 375 bits (962), Expect = e-103
Identities = 254/819 (31%), Positives = 399/819 (48%), Gaps = 70/819 (8%)
Query: 600 VKEDFSKCIKILKFEEGETILCQNSNPQGIYYLVSGEVDVISETK-DGNTDESYERTLYT 658
V E I + +E G I+ Q + + + ++ G + + E+ D +E E +
Sbjct: 470 VSEQIGSKIHLESYEAGHVIIEQGAEEEVLMMVLHGNLILAQESLFDEENNEEDESAVIR 529
Query: 659 ATEGYILGYLSSILGCKSLVTLKVSKGPAYLGLIPYNDLERLCDKYFMIYLKLSEILTNS 718
T ++G L + S T++ + + ++ D + + IYL ++ +
Sbjct: 530 VTARELVGGLQILTNEPSFYTIRAAV-QTRVAIMKKKDFSAFLEAHPEIYLPVAHSVLRR 588
Query: 719 LSPNLLRLDYFLEWIQLDSSETLFNQGDPANGVYLVLNGRLRQLFYEDADSDIVTQMAEL 778
LSP L +D+ L+W+ +DS + GD A+ +++VL+GRLR + + T + E
Sbjct: 589 LSPFLRGVDFALDWVLVDSGHACYRAGDMADSLFVVLSGRLRSV-------EKKTVVEEF 641
Query: 779 SKGESFGEVEVLTAIHRLNTVVAIRDTELARIPRTLFEFLAVEHPSIMIHVSRMVAKKAM 838
+G+ G +EVLT R TV+A+R ++LAR+P L F+ +++P + + +++ +
Sbjct: 642 GRGDVLGMMEVLTKKPRATTVLAVRFSQLARVPEGLLNFIKMQYPQVGFRLVQLLGQYYS 701
Query: 839 LMNFKSGIGFSGSQPI-TKLIGDETAMQKRYDFXXXXXXXXXXXXXXXXXXTVNYKTLTL 897
N ++ F+ I T +G M N T+ +
Sbjct: 702 QTNRRAP--FAAPTVIRTNELGATDPMSH----------------------IKNLHTIAV 737
Query: 898 LPITEGLPVEEFAYKLINALRQCGKTTIGLNQRTTLSHLGRHAFNKLSKLKQSGYFAELE 957
+P + +P+ F +L +AL + L+ + + L K + + + E
Sbjct: 738 VPASPDVPLVPFTCELYHALSS-NLRVLRLSSQKVAACLDPSVLEKQADFRLMHWLNVQE 796
Query: 958 ELYEIVVYIADTPVSSSWTQTCISQGDCILLLADATCDPKIGEFERLLLK-SKTTART-- 1014
+ Y +V+Y D ++WT+ C+ Q D IL++A P+ R L+ ++ RT
Sbjct: 797 DTYPLVIYECDF-TQTNWTRRCLRQADAILVVAIGGKTPEKQTLMRELMNMNQDGVRTNK 855
Query: 1015 DLILLHPERYVVPGSTSKWLKNRMWIQSHHHIQFTPMEKVAEPDPIPNIKPLSQLVEKFK 1074
+LILL PE P T +WLKN + HHHI+ K + Q KF+
Sbjct: 856 ELILLWPESTKTPSGTIEWLKNS-YFSGHHHIRAP--------------KRMLQWNRKFR 900
Query: 1075 ENTKKTQENFVKFLPDSIKTTVETLSGKYIDPKPNPKFYTSVDPIKNDFLRLARTXXXXX 1134
+ ++ P S++ V K + P+ + +DF RLAR
Sbjct: 901 KMSRAEV-----MTPTSVENEVIEYYEKNVFWTPDRR---------SDFSRLARILTGNA 946
Query: 1135 XXXXXXXXXXXXXXXXXIIKALEEQGIPIDIIGGTSIGSFVGGLYAMDYDLVPIYGRVKK 1194
+++AL E+GIP+DI+GGTSIGS +GGLYA D V + R
Sbjct: 947 IGLVLGGGGARGAAHVGVLRALREEGIPVDIVGGTSIGSLIGGLYAETPDDVVVETRAAS 1006
Query: 1195 FAGRVGSLWRMLSDLTWPVTSYTTGHEFNRGIWKSFRDYRIEDFWISYYCNSTNITESVQ 1254
+ + SLWR L DLT+ ++ TG +FN I F + IED WISY+C ST+I+ S
Sbjct: 1007 WFNGMSSLWRKLLDLTYAHSAMFTGAQFNFSIKDLFEERLIEDLWISYFCISTDISTSEM 1066
Query: 1255 EIHSSGFAWRYIRASMSLAGLLPPIVD--NGNMLLDGGYVDNLPVTEMTQRGCKIVFAVD 1312
+H SG W Y RASMSLAG LPP+ D +G++LLDGGYV+N+P M G + V A D
Sbjct: 1067 RVHRSGPLWAYCRASMSLAGYLPPLCDPQDGHLLLDGGYVNNVPADVMRNLGARCVIACD 1126
Query: 1313 VGSVDDRTPMSYGDSLNGFWIVLNRWNPFSKHPNIPNMAEIQMRLGYVASVNALERAKST 1372
VGS+++ YGDSL+G W++L R NPF P I NM EIQ RL YV+ V LE K
Sbjct: 1127 VGSIEETNLYDYGDSLSGMWVLLKRLNPFGTPPRILNMEEIQSRLAYVSCVRQLEVVKKA 1186
Query: 1373 PGVVYIRPPIENYATLDFGKFEEIYQVGYAYGHDFLQHL 1411
Y+RPPIE + TLDF KF+EI ++G YG + L
Sbjct: 1187 SYCRYLRPPIEPFKTLDFPKFQEIMELGLKYGREACHEL 1225
>CE29641 [R] KOG2968 Predicted esterase of the alpha-beta hydrolase
superfamily (Neuropathy target esterase) contains
cAMP-binding domains
Length = 1371
Score = 369 bits (947), Expect = e-101
Identities = 254/830 (30%), Positives = 400/830 (47%), Gaps = 81/830 (9%)
Query: 600 VKEDFSKCIKILKFEEGETILCQNSNPQGIYYLVSGEV-------DVISETK-----DGN 647
V E I + +E G I+ Q + + + ++ G + D ++ + D
Sbjct: 470 VSEQIGSKIHLESYEAGHVIIEQGAEEEVLMMVLHGNLILAQYGSDFFAQIERESLFDEE 529
Query: 648 TDESYERTLYTATEGYILGYLSSILGCKSLVTLKVSKGPAYLGLIPYNDLERLCDKYFMI 707
+E E + T ++G L + S T++ + + ++ D + + I
Sbjct: 530 NNEEDESAVIRVTARELVGGLQILTNEPSFYTIRAAV-QTRVAIMKKKDFSAFLEAHPEI 588
Query: 708 YLKLSEILTNSLSPNLLRLDYFLEWIQLDSSETLFNQGDPANGVYLVLNGRLRQLFYEDA 767
YL ++ + LSP L +D+ L+W+ +DS + GD A+ +++VL+GRLR +
Sbjct: 589 YLPVAHSVLRRLSPFLRGVDFALDWVLVDSGHACYRAGDMADSLFVVLSGRLRSV----- 643
Query: 768 DSDIVTQMAELSKGESFGEVEVLTAIHRLNTVVAIRDTELARIPRTLFEFLAVEHPSIMI 827
+ T + E +G+ G +EVLT R TV+A+R ++LAR+P L F+ +++P +
Sbjct: 644 --EKKTVVEEFGRGDVLGMMEVLTKKPRATTVLAVRFSQLARVPEGLLNFIKMQYPQVGF 701
Query: 828 HVSRMVAKKAMLMNFKSGIGFSGSQPI-TKLIGDETAMQKRYDFXXXXXXXXXXXXXXXX 886
+ +++ + N ++ F+ I T +G M
Sbjct: 702 RLVQLLGQYYSQTNRRAP--FAAPTVIRTNELGATDPMSH-------------------- 739
Query: 887 XXTVNYKTLTLLPITEGLPVEEFAYKLINALRQCGKTTIGLNQRTTLSHLGRHAFNKLSK 946
N T+ ++P + +P+ F +L +AL + L+ + + L K +
Sbjct: 740 --IKNLHTIAVVPASPDVPLVPFTCELYHALSS-NLRVLRLSSQKVAACLDPSVLEKQAD 796
Query: 947 LKQSGYFAELEELYEIVVYIADTPVSSSWTQTCISQGDCILLLADATCDPKIGEFERLLL 1006
+ + E+ Y +V+Y D ++WT+ C+ Q D IL++A P+ R L+
Sbjct: 797 FRLMHWLNVQEDTYPLVIYECDF-TQTNWTRRCLRQADAILVVAIGGKTPEKQTLMRELM 855
Query: 1007 K-SKTTART--DLILLHPERYVVPGSTSKWLKNRMWIQSHHHIQFTPMEKVAEPDPIPNI 1063
++ RT +LILL PE P T +WLKN + HHHI+
Sbjct: 856 NMNQDGVRTNKELILLWPESTKTPSGTIEWLKNS-YFSGHHHIRAP-------------- 900
Query: 1064 KPLSQLVEKFKENTKKTQENFVKFLPDSIKTTVETLSGKYIDPKPNPKFYTSVDPIKNDF 1123
K + Q KF++ ++ P S++ V K + P+ + +DF
Sbjct: 901 KRMLQWNRKFRKMSRAEV-----MTPTSVENEVIEYYEKNVFWTPDRR---------SDF 946
Query: 1124 LRLARTXXXXXXXXXXXXXXXXXXXXXXIIKALEEQGIPIDIIGGTSIGSFVGGLYAMDY 1183
RLAR +++AL E+GIP+DI+GGTSIGS +GGLYA
Sbjct: 947 SRLARILTGNAIGLVLGGGGARGAAHVGVLRALREEGIPVDIVGGTSIGSLIGGLYAETP 1006
Query: 1184 DLVPIYGRVKKFAGRVGSLWRMLSDLTWPVTSYTTGHEFNRGIWKSFRDYRIEDFWISYY 1243
D V + R + + SLWR L DLT+ ++ TG +FN I F + IED WISY+
Sbjct: 1007 DDVVVETRAASWFNGMSSLWRKLLDLTYAHSAMFTGAQFNFSIKDLFEERLIEDLWISYF 1066
Query: 1244 CNSTNITESVQEIHSSGFAWRYIRASMSLAGLLPPIVD--NGNMLLDGGYVDNLPVTEMT 1301
C ST+I+ S +H SG W Y RASMSLAG LPP+ D +G++LLDGGYV+N+P M
Sbjct: 1067 CISTDISTSEMRVHRSGPLWAYCRASMSLAGYLPPLCDPQDGHLLLDGGYVNNVPADVMR 1126
Query: 1302 QRGCKIVFAVDVGSVDDRTPMSYGDSLNGFWIVLNRWNPFSKHPNIPNMAEIQMRLGYVA 1361
G + V A DVGS+++ YGDSL+G W++L R NPF P I NM EIQ RL YV+
Sbjct: 1127 NLGARCVIACDVGSIEETNLYDYGDSLSGMWVLLKRLNPFGTPPRILNMEEIQSRLAYVS 1186
Query: 1362 SVNALERAKSTPGVVYIRPPIENYATLDFGKFEEIYQVGYAYGHDFLQHL 1411
V LE K Y+RPPIE + TLDF KF+EI ++G YG + L
Sbjct: 1187 CVRQLEVVKKASYCRYLRPPIEPFKTLDFPKFQEIMELGLKYGREACHEL 1236
>Hs20537616 [R] KOG2968 Predicted esterase of the alpha-beta hydrolase
superfamily (Neuropathy target esterase) contains
cAMP-binding domains
Length = 702
Score = 360 bits (924), Expect = 9e-99
Identities = 219/654 (33%), Positives = 335/654 (50%), Gaps = 75/654 (11%)
Query: 754 VLNGRLRQLFYEDADSDIVTQMAELSKGESFGEVEVLTAIHRLNTVVAIRDTELARIPRT 813
+L+GRLR + +D + E +G+ G VE LT R TV A+RD+ELA++P
Sbjct: 1 MLSGRLRSVIRKDDGKKRLA--GEYGRGDLVGVVETLTHQARATTVHAVRDSELAKLPAG 58
Query: 814 LFEFLAVEHPSIMIHVSRMVAKKAMLMNFKSGIGFSGSQPIT-KLIGDETAMQKRYDFXX 872
+ +P ++ + ++ +K + G P+T +G T K +D
Sbjct: 59 ALTSIKRRYPQVVTRLIHLLGEKIL--------GSLQQGPVTGHQLGLPTEGSK-WDLGN 109
Query: 873 XXXXXXXXXXXXXXXXTVNYKTLTLLPITEGLPVEEFAYKLINALRQCGKTTIGLNQRTT 932
VN T+ ++P++E +P+ FA +L +AL G T + L
Sbjct: 110 PA---------------VNLSTVAVMPVSEEVPLTAFALELEHALSAIGPTLL-LTSDNI 153
Query: 933 LSHLGRHAFNKLSKLKQSGYFAELEELYEIVVYIADTPVSSSWTQTCISQGDCILLLADA 992
LG A + + + + S + + E+ + IV+Y D ++ WTQ C+ Q DCIL++
Sbjct: 154 KRRLGSAALDSVHEYRLSSWLGQQEDTHRIVLYQVDGTLTP-WTQRCVRQADCILIVGLG 212
Query: 993 TCDPKIGEFERLLLKSKTTARTDLILLHPERYVVPGSTSKWLKNRMWIQSHHHIQFTPME 1052
+P +GE ER+L + A+ LILLH E P T +WL R W H H+
Sbjct: 213 DQEPTVGELERMLESTAVRAQKQLILLHREEGPAPARTVEWLNMRSWCSGHLHL------ 266
Query: 1053 KVAEPDPIPNIKPLSQLVEKFKENTKKTQENFVKFLPDSIKTTVETLSGKYIDPKPNPKF 1112
P + + + L +LVE +K ++ +
Sbjct: 267 --CCPRRVFSRRSLPKLVEMYKHVFQRPPDRH---------------------------- 296
Query: 1113 YTSVDPIKNDFLRLARTXXXXXXXXXXXXXXXXXXXXXXIIKALEEQGIPIDIIGGTSIG 1172
+DF RLAR ++KAL E GIP+D++GGTSIG
Sbjct: 297 --------SDFSRLARVLTGNAIALVLGGGGARGCAQVGVLKALAECGIPVDMVGGTSIG 348
Query: 1173 SFVGGLYAMDYDLVPIYGRVKKFAGRVGSLWRMLSDLTWPVTSYTTGHEFNRGIWKSFRD 1232
+FVG LY+ + + + R K++A + SL + DLT+P+TS +G FN I+ F+D
Sbjct: 349 AFVGALYSEERNYSQMRIRAKQWAEGMTSLMKAALDLTYPITSMFSGAGFNSSIFSVFKD 408
Query: 1233 YRIEDFWISYYCNSTNITESVQEIHSSGFAWRYIRASMSLAGLLPPIVD--NGNMLLDGG 1290
+IED WI Y+ +T+IT S +H+ G W Y+RASMSL+G +PP+ D +G++L+DGG
Sbjct: 409 QQIEDLWIPYFAITTDITASAMRVHTDGSLWWYVRASMSLSGYMPPLCDPKDGHLLMDGG 468
Query: 1291 YVDNLPVTEMTQRGCKIVFAVDVGSVDDRTPMSYGDSLNGFWIVLNRWNPFSKHPNIPNM 1350
Y++NLP G K+V A+DVGS D+ +YGD+L+G+W++ RWNP + + NM
Sbjct: 469 YINNLPADVARSMGAKVVIAIDVGSRDETDLTNYGDALSGWWLLWKRWNPLATKVKVLNM 528
Query: 1351 AEIQMRLGYVASVNALERAKSTPGVVYIRPPIENYATLDFGKFEEIYQVGYAYG 1404
AEIQ RL YV V LE KS+ Y+RPPI++Y+TLDFGKF EI +VGY +G
Sbjct: 529 AEIQTRLAYVCCVRQLEVVKSSDYCEYLRPPIDSYSTLDFGKFNEICEVGYQHG 582
>CE03510 [R] KOG2968 Predicted esterase of the alpha-beta hydrolase
superfamily (Neuropathy target esterase) contains
cAMP-binding domains
Length = 880
Score = 262 bits (669), Expect = 3e-69
Identities = 193/704 (27%), Positives = 312/704 (43%), Gaps = 120/704 (17%)
Query: 706 MIYLKLSEILTNSLSPNLLRLDYFLEWIQLDSSETLFNQGDPANGVYLVLNGRLRQLFYE 765
+IYL+L+ +SP D + W ++++ + LF QGD ++ +++V+ GRLR +
Sbjct: 230 VIYLRLAFHALQFISPFARVFDMAVHWHRIETGQALFRQGDKSDSMHIVMGGRLRAV--- 286
Query: 766 DADSDIVTQMAELSKGESFGEVEVLTAIHRLNTVVAIRDTELARIPRTLFEFLAVEHPSI 825
D + E + + G ++ R NTV+A+R + + IP L F+ + +P +
Sbjct: 287 ----DSTKIIEEYGRLDLIGITDMAEKRPRRNTVMAVRFSHIVCIPENLLSFVKIRYPQV 342
Query: 826 MIHVSRMVAKKAMLMNFKSGIGFSGSQPITKLIGDETAMQKRYDFXXXXXXXXXXXXXXX 885
+A R DF
Sbjct: 343 -----------------------------------NSARWSRRDF--------------- 352
Query: 886 XXXTVNYKTLTLLPITEGLPVEEFAYKLINALRQCGKTTIGLNQRTTLSHLGRHAFNKLS 945
+ +P+T EF +L N L + K T+ L+ ++ K +
Sbjct: 353 ----TEFSASRRVPLT------EFTCELYNQLSKHVK-TLRLSSSVVENYFESEVITKKA 401
Query: 946 KLKQSGYFAELEELYEIVVYIADTPVSSSWTQTCISQGDCILLLADATCDPKIGEFERLL 1005
+ E Y +V+Y D ++WT+ C+ D IL++A T + L
Sbjct: 402 DYGLMHWLNVQEIAYSLVLYQCDFH-KTNWTRRCLRMADAILMVALGTESKEEQVLAEAL 460
Query: 1006 L---KSKTTARTDLILLHPERYVVPGSTSKWLKNRMWIQSHHHIQFTPMEKVAEPDPIPN 1062
L + +L+ L P P T+ W+K + +HH++ PN
Sbjct: 461 LSCNEKGVRQSKELVFLWPIDTPTPSGTAAWIK-ESYYSGYHHLR------------APN 507
Query: 1063 IKPLSQLVEKFKENTKKTQENFVKFLPDSIKTTVETLSGKYIDPKPNPKFYTSVDPIKND 1122
F K ++ V++ +TTV Y + ++D
Sbjct: 508 --------RLFSFPLKTREKKIVEY----YETTV----------------YGEIS-YQSD 538
Query: 1123 FLRLARTXXXXXXXXXXXXXXXXXXXXXXIIKALEEQGIPIDIIGGTSIGSFVGGLYAMD 1182
F RLAR ++AL E+ + ID++GGTSIG+ G LYA
Sbjct: 539 FSRLARILTGNAIGIVFGGGGARGAAHAGALRALIEKKVQIDMVGGTSIGALFGSLYATT 598
Query: 1183 YDLVPIYGRVKK-FAGRV-GSLWRMLSDLTWPVTSYTTGHEFNRGIWKSFRDYRIEDFWI 1240
D+ + GR+K F R+ ++ ++ DLTWP TGH FN + + D IED W+
Sbjct: 599 PDIRAV-GRMKDFFTDRLRNNILDVVRDLTWPYCGILTGHRFNLCVQRMLNDVNIEDCWV 657
Query: 1241 SYYCNSTNITESVQEIHSSGFAWRYIRASMSLAGLLPPIVD--NGNMLLDGGYVDNLPVT 1298
S++C +T++T S IH +G W +R+SMS+AG +PPI D +G++LLDG YV+NLP
Sbjct: 658 SFFCITTDLTSSSMRIHRNGIMWPVVRSSMSIAGYVPPICDPQDGHLLLDGAYVNNLPAD 717
Query: 1299 EMTQRGCKIVFAVDVGSVDDRTPM-SYGDSLNGFWIVLNRWNPFSKHPNIPNMAEIQMRL 1357
M G +V A+DVG DD T + +YG S++G W + RW PF + + NM E+Q RL
Sbjct: 718 IMRSLGANVVIAIDVGMSDDNTNLRNYGFSISGTWCLFKRWWPFGEELRVLNMNEVQNRL 777
Query: 1358 GYVASVNALERAKSTPGVVYIRPPIENYATLDFGKFEEIYQVGY 1401
YV VN +E K+ Y++ PIE++ DF KF++ Q+GY
Sbjct: 778 AYVCCVNQMEIVKNAQYCYYVKLPIESFGIFDFSKFDQAAQIGY 821
>ECU05g0070 [R] KOG2968 Predicted esterase of the alpha-beta hydrolase
superfamily (Neuropathy target esterase) contains
cAMP-binding domains
Length = 905
Score = 229 bits (584), Expect = 2e-59
Identities = 109/280 (38%), Positives = 168/280 (59%), Gaps = 3/280 (1%)
Query: 1122 DFLRLARTXXXXXXXXXXXXXXXXXXXXXXIIKALEEQGIPIDIIGGTSIGSFVGGLYAM 1181
DF RLAR+ +I+ALEE+GIPID +GGTS+G+F+G LYA
Sbjct: 595 DFQRLARSLLGKRIGLVLGGGGARGLAHIGVIQALEEEGIPIDCVGGTSMGAFIGALYAK 654
Query: 1182 DYDLVPIYGRVKKFAGRVGSLWRMLSDLTWPVTSYTTGHEFNRGIWKSFRDYRIEDFWIS 1241
+ + ++ + K+F+ ++ ++W +L DLT+P+ S +GH FNR + F D I+D W+
Sbjct: 655 ECNNYHVFKQAKRFSRKMSNIWILLLDLTYPICSMFSGHAFNRSLHSIFGDGLIQDLWLE 714
Query: 1242 YYCNSTNITESVQEIHSSGFAWRYIRASMSLAGLLPPIVDNGNMLLDGGYVDNLPVTEMT 1301
Y+C +TNI +E+H +G WRY+RASM L G LPPI DN +L+DGGY++N+P M
Sbjct: 715 YFCITTNIVSYEEEVHRNGMVWRYVRASMGLCGYLPPICDNKKLLVDGGYLNNVPADVMM 774
Query: 1302 QRGCKIVFAVDVGSVDDRTPMSYGDSLNGFWIVLNRWNPFSKHPNIPNMAEIQMRLGYVA 1361
+ + VDVG+V + YGD+L+GF I+ N+ F + M EIQ RL Y++
Sbjct: 775 GMQVEKIITVDVGTVLENDHFDYGDTLSGFTILFNK---FFGNKKFVTMEEIQYRLAYIS 831
Query: 1362 SVNALERAKSTPGVVYIRPPIENYATLDFGKFEEIYQVGY 1401
+ ++ ++ ++ +RP + Y T+DF KF+EI GY
Sbjct: 832 TERKMKELEANGNIIMLRPDLGKYRTMDFKKFDEIVACGY 871
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.318 0.135 0.393
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 82,386,622
Number of Sequences: 60738
Number of extensions: 3537865
Number of successful extensions: 9388
Number of sequences better than 1.0e-05: 9
Number of HSP's better than 0.0 without gapping: 9
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 9302
Number of HSP's gapped (non-prelim): 39
length of query: 1441
length of database: 30,389,216
effective HSP length: 119
effective length of query: 1322
effective length of database: 23,161,394
effective search space: 30619362868
effective search space used: 30619362868
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)