ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactII1352 good G KOG2504 Carbohydrate transport and metabolism Monocarboxylate transporter
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactII1352 Some similarity with YKL221w SP|P36032
{P4.39.f4.1}
(196 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YKL221w [G] KOG2504 Monocarboxylate transporter 171 4e-43
YNL125c [G] KOG2504 Monocarboxylate transporter 91 1e-18
YOL119c [G] KOG2504 Monocarboxylate transporter 49 6e-06
Hs22064599 [G] KOG2504 Monocarboxylate transporter 45 6e-05
Hs4759120 [G] KOG2504 Monocarboxylate transporter 42 5e-04
YOR306c [G] KOG2504 Monocarboxylate transporter 39 0.005
Hs4759112 [G] KOG2504 Monocarboxylate transporter 38 0.008
Hs7019529 [G] KOG2504 Monocarboxylate transporter 38 0.010
CE21446 [G] KOG2504 Monocarboxylate transporter 37 0.017
CE20478 [G] KOG2504 Monocarboxylate transporter 37 0.017
Hs4759118 [G] KOG2504 Monocarboxylate transporter 36 0.029
7292012 [G] KOG2504 Monocarboxylate transporter 36 0.038
Hs20559959 [G] KOG2504 Monocarboxylate transporter 35 0.085
Hs18699730 [G] KOG2504 Monocarboxylate transporter 33 0.19
Hs19923753 [G] KOG2504 Monocarboxylate transporter 33 0.25
Hs4759116 [G] KOG2504 Monocarboxylate transporter 31 0.94
Hs5730045 [G] KOG2504 Monocarboxylate transporter 31 1.2
7303562 [G] KOG2504 Monocarboxylate transporter 30 1.6
CE12336 [G] KOG2504 Monocarboxylate transporter 29 4.7
7299667 [G] KOG2504 Monocarboxylate transporter 29 4.7
SPAC4G9.20c [C] KOG0758 Mitochondrial carnitine-acylcarnitine ca... 28 8.0
>YKL221w [G] KOG2504 Monocarboxylate transporter
Length = 473
Score = 171 bits (434), Expect = 4e-43
Identities = 85/180 (47%), Positives = 106/180 (58%)
Query: 1 MYNFCTWGANAGYAVYLATYLSRDVFPGGGKLDYXXXXXXXXXXXXXXXPVIIYFSRNYG 60
+YNF TWGAN+GYA+YLA YL + F GG KLDY PVI + +
Sbjct: 50 LYNFSTWGANSGYAIYLAHYLENNTFAGGSKLDYASIGGLAFSCGLFFAPVITWLYHIFS 109
Query: 61 VHVVIGLGIICQCXXXXXXXFSKKLWQIYLTQGLLISFGLALICTPSMGLIPQWFRKRRT 120
+ +IGLGI+ Q FS LW+IYLTQG+LI FGLA I PS+ LIP WFR +R+
Sbjct: 110 IQFIIGLGILFQGAALLLAAFSVTLWEIYLTQGVLIGFGLAFIFIPSVTLIPLWFRNKRS 169
Query: 121 XXXXXXXXXXXXXXXXXXXXMQKIIEVKSVKWALIVQCIICTSLSTLALILTRTRNQHIR 180
MQ I++ + VKWALI QCIICTSLST+AL+LTRT +Q +R
Sbjct: 170 LASGIGTAGSGLGGIVFNLGMQSILQKRGVKWALIAQCIICTSLSTIALMLTRTTHQGLR 229
>YNL125c [G] KOG2504 Monocarboxylate transporter
Length = 673
Score = 90.9 bits (224), Expect = 1e-18
Identities = 47/174 (27%), Positives = 76/174 (43%), Gaps = 1/174 (0%)
Query: 4 FCTWGANAGYAVYLATYLSRDVFPGGGKLDYXXXXXXXXXXXXXXXPVIIYFSRNYGVHV 63
F TWG NA + V LA YL+ D +PG K DY P+++ R G+
Sbjct: 224 FSTWGCNASFGVDLAYYLNHDTYPGASKYDYALIAGLTVFLGQLLSPLVMALMRIIGLRT 283
Query: 64 VIGLGIICQCXXXXXXXFSKKLWQIYLTQGLLISFGLALICTPSMGLIPQWFRKRRTXXX 123
+ G F+ KLWQ+Y+TQG ++ ++LI P+ ++P WF K+R
Sbjct: 284 TMLFGDAVMLAAYLLASFTTKLWQLYVTQGFMVGCSISLIFVPATTVLPGWFLKKRAVAM 343
Query: 124 XXXXXXXXXXXXXXXXXMQKII-EVKSVKWALIVQCIICTSLSTLALILTRTRN 176
K++ + + +W L + I C+ +A+ L + RN
Sbjct: 344 GVSLLGTGAGGVVYGLATNKMLSDFGNTRWCLRIIGISCSISVLVAIALLKERN 397
>YOL119c [G] KOG2504 Monocarboxylate transporter
Length = 501
Score = 48.5 bits (114), Expect = 6e-06
Identities = 30/138 (21%), Positives = 52/138 (36%), Gaps = 7/138 (5%)
Query: 54 YFSRNYGVHVVIGLGIICQCXXXXXXXFSKKLWQIYLTQGLLISFGLALICTPSMGLIPQ 113
YF RN + ++ G + K +WQ L + G ++ TP +G +
Sbjct: 158 YFDRNGSIGLMC-TGTVIYAGGLFALANCKSVWQFILAFSVCSGLGTGILMTPLIGTVAT 216
Query: 114 WFRKRRTXXXXXXXXXXXXXXXXXXXXMQKIIEVKSVKWALIVQCIICTSLSTLALILTR 173
WF KRR ++K+ + +WA+ + IC + A +L R
Sbjct: 217 WFLKRRGIATSISTMGGSIGGIVFPIMLRKLYKEVGFQWAIRILSFICLTCLICASVLAR 276
Query: 174 TRNQHIRGSAQQTQPLRS 191
R + + QP +S
Sbjct: 277 ERTKPV------VQPFKS 288
>Hs22064599 [G] KOG2504 Monocarboxylate transporter
Length = 579
Score = 45.1 bits (105), Expect = 6e-05
Identities = 28/122 (22%), Positives = 50/122 (40%)
Query: 50 PVIIYFSRNYGVHVVIGLGIICQCXXXXXXXFSKKLWQIYLTQGLLISFGLALICTPSMG 109
PV S +G V+ +G + F+ L +YL GLL FG AL+ P++G
Sbjct: 201 PVGSALSTRWGARPVVMVGGVLASLGFVFSAFASDLLHLYLGLGLLAGFGWALVFAPALG 260
Query: 110 LIPQWFRKRRTXXXXXXXXXXXXXXXXXXXXMQKIIEVKSVKWALIVQCIICTSLSTLAL 169
+ ++F +RR +Q +++ + AL++ I L+
Sbjct: 261 TLSRYFSRRRVLAVGLALTGNGASSLLLAPALQLLLDTFGWRGALLLLGAITLHLTPCGA 320
Query: 170 IL 171
+L
Sbjct: 321 LL 322
>Hs4759120 [G] KOG2504 Monocarboxylate transporter
Length = 478
Score = 42.0 bits (97), Expect = 5e-04
Identities = 24/71 (33%), Positives = 36/71 (49%), Gaps = 2/71 (2%)
Query: 50 PVIIYFSRNYGVH-VVIGLGIICQCXXXXXXXFSKKLWQIYLTQGLLISFGLALICTPSM 108
PV YG VVI G++C C FS + Q+YLT G + GLA P++
Sbjct: 74 PVSSVLVNKYGSRPVVIAGGLLC-CLGMVLASFSSSVVQLYLTMGFITGLGLAFNLQPAL 132
Query: 109 GLIPQWFRKRR 119
+I ++F ++R
Sbjct: 133 TIIGKYFYRKR 143
>YOR306c [G] KOG2504 Monocarboxylate transporter
Length = 521
Score = 38.9 bits (89), Expect = 0.005
Identities = 27/133 (20%), Positives = 50/133 (37%), Gaps = 8/133 (6%)
Query: 54 YFSRNYGVHVVIGLGIICQCXXXXXXXFSKKLWQIYLTQGLLISFGLALICTPSMGLIPQ 113
YF RN G ++ +G + S K W L+ ++ FG ++ +P + +
Sbjct: 168 YFDRN-GFRTIMIVGTVFHVAGLFATANSTKYWHFILSFAIVCGFGNGIVLSPLVSVPAH 226
Query: 114 WFRKRRTXXXXXXXXXXXXXXXXXXXXMQKIIEVKS-------VKWALIVQCIICTSLST 166
+F KRR ++ +KS W + + +L T
Sbjct: 227 YFFKRRGTALAMATIGGSVGGVVFPIMLRSFFSMKSDTDPTYGFVWGIRTLGFLDLALLT 286
Query: 167 LALILTRTRNQHI 179
L++IL + R H+
Sbjct: 287 LSIILVKERLPHV 299
>Hs4759112 [G] KOG2504 Monocarboxylate transporter
Length = 465
Score = 38.1 bits (87), Expect = 0.008
Identities = 19/61 (31%), Positives = 33/61 (53%)
Query: 59 YGVHVVIGLGIICQCXXXXXXXFSKKLWQIYLTQGLLISFGLALICTPSMGLIPQWFRKR 118
+G V+ +G + F + + Q+YLT G++ GLAL PS+ ++ ++F KR
Sbjct: 85 FGCRPVMLVGGLFASLGMVAASFCRSIIQVYLTTGVITGLGLALNFQPSLIMLNRYFSKR 144
Query: 119 R 119
R
Sbjct: 145 R 145
>Hs7019529 [G] KOG2504 Monocarboxylate transporter
Length = 504
Score = 37.7 bits (86), Expect = 0.010
Identities = 21/70 (30%), Positives = 34/70 (48%)
Query: 50 PVIIYFSRNYGVHVVIGLGIICQCXXXXXXXFSKKLWQIYLTQGLLISFGLALICTPSMG 109
PV +G V+ G + F+ +L ++YLT G+L GLAL PS+
Sbjct: 73 PVSSILVTRFGCRPVMLAGGLLASAGMILASFATRLLELYLTAGVLTGLGLALNFQPSLI 132
Query: 110 LIPQWFRKRR 119
++ +F +RR
Sbjct: 133 MLGLYFERRR 142
>CE21446 [G] KOG2504 Monocarboxylate transporter
Length = 666
Score = 37.0 bits (84), Expect = 0.017
Identities = 18/71 (25%), Positives = 33/71 (46%)
Query: 50 PVIIYFSRNYGVHVVIGLGIICQCXXXXXXXFSKKLWQIYLTQGLLISFGLALICTPSMG 109
P+ F +G+ V G I F+ +W++YL G+L G + PS+
Sbjct: 100 PLASSFVNVFGIRSVAIAGSILATTAFLLSRFASTIWELYLLFGVLGGIGFGCMYLPSIV 159
Query: 110 LIPQWFRKRRT 120
++ +F K+R+
Sbjct: 160 ILSTYFAKKRS 170
>CE20478 [G] KOG2504 Monocarboxylate transporter
Length = 571
Score = 37.0 bits (84), Expect = 0.017
Identities = 18/71 (25%), Positives = 33/71 (46%)
Query: 50 PVIIYFSRNYGVHVVIGLGIICQCXXXXXXXFSKKLWQIYLTQGLLISFGLALICTPSMG 109
P+ F +G+ V G I F+ +W++YL G+L G + PS+
Sbjct: 100 PLASSFVNVFGIRSVAIAGSILATTAFLLSRFASTIWELYLLFGVLGGIGFGCMYLPSIV 159
Query: 110 LIPQWFRKRRT 120
++ +F K+R+
Sbjct: 160 ILSTYFAKKRS 170
>Hs4759118 [G] KOG2504 Monocarboxylate transporter
Length = 523
Score = 36.2 bits (82), Expect = 0.029
Identities = 17/71 (23%), Positives = 35/71 (48%)
Query: 50 PVIIYFSRNYGVHVVIGLGIICQCXXXXXXXFSKKLWQIYLTQGLLISFGLALICTPSMG 109
P+ S +G +V+ LG + FS+++ +Y+ G++ G P++
Sbjct: 79 PLATVLSNRFGHRLVVMLGGLLVSTGMVAASFSQEVSHMYVAIGIISGLGYCFSFLPTVT 138
Query: 110 LIPQWFRKRRT 120
++ Q+F KRR+
Sbjct: 139 ILSQYFGKRRS 149
>7292012 [G] KOG2504 Monocarboxylate transporter
Length = 816
Score = 35.8 bits (81), Expect = 0.038
Identities = 17/71 (23%), Positives = 30/71 (41%)
Query: 50 PVIIYFSRNYGVHVVIGLGIICQCXXXXXXXFSKKLWQIYLTQGLLISFGLALICTPSMG 109
P++ + YG V G I C FS + + T G + FG +I P++
Sbjct: 132 PIVSALANKYGCRAVCIAGSIIACIAFVLSTFSTNVSMLMATYGFMGGFGFGMIYLPAVV 191
Query: 110 LIPQWFRKRRT 120
+ +F +R+
Sbjct: 192 AVGYYFETKRS 202
>Hs20559959 [G] KOG2504 Monocarboxylate transporter
Length = 426
Score = 34.7 bits (78), Expect = 0.085
Identities = 21/71 (29%), Positives = 32/71 (44%)
Query: 50 PVIIYFSRNYGVHVVIGLGIICQCXXXXXXXFSKKLWQIYLTQGLLISFGLALICTPSMG 109
PV S +G V+ G I F+ L +YL+ GLL G AL P++
Sbjct: 68 PVGSALSTKFGPRPVVMTGGILAALGMLLASFATSLTHLYLSIGLLSGSGWALTFAPTLA 127
Query: 110 LIPQWFRKRRT 120
+ +F +RR+
Sbjct: 128 CLSCYFSRRRS 138
>Hs18699730 [G] KOG2504 Monocarboxylate transporter
Length = 515
Score = 33.5 bits (75), Expect = 0.19
Identities = 26/137 (18%), Positives = 52/137 (36%), Gaps = 4/137 (2%)
Query: 50 PVIIYFSRNYGVHVVIGLGIICQCXXXXXXXFSKKLWQIYLTQGLLISFGLALICTPSMG 109
P++ F+ +G +G F + +YLT G++ + G + PS+
Sbjct: 130 PIVSVFTDLFGCRKTAVVGAAVGFVGLMSSSFVSSIEPLYLTYGIIFACGCSFAYQPSLV 189
Query: 110 LIPQWFRKRRTXXXXXXXXXXXXXXXXXXXXMQKIIEVKSVKWALIVQCIICTSL----S 165
++ +F+KR ++ +I+ + + L V CI L
Sbjct: 190 ILGHYFKKRLGLVNGIVTAGSSVFTILLPLLLRVLIDSVGLFYTLRVLCIFMFVLFLAGF 249
Query: 166 TLALILTRTRNQHIRGS 182
T + T T+++ GS
Sbjct: 250 TYRPLATSTKDKESGGS 266
>Hs19923753 [G] KOG2504 Monocarboxylate transporter
Length = 500
Score = 33.1 bits (74), Expect = 0.25
Identities = 18/70 (25%), Positives = 32/70 (45%)
Query: 50 PVIIYFSRNYGVHVVIGLGIICQCXXXXXXXFSKKLWQIYLTQGLLISFGLALICTPSMG 109
P+ YG +V+ +G F + Q+Y+ G++ GLA P++
Sbjct: 74 PISSILVNKYGSRIVMIVGGCLSGCGLIAASFCNTVQQLYVCIGVIGGLGLAFNLNPALT 133
Query: 110 LIPQWFRKRR 119
+I ++F KRR
Sbjct: 134 MIGKYFYKRR 143
>Hs4759116 [G] KOG2504 Monocarboxylate transporter
Length = 505
Score = 31.2 bits (69), Expect = 0.94
Identities = 16/61 (26%), Positives = 27/61 (44%)
Query: 59 YGVHVVIGLGIICQCXXXXXXXFSKKLWQIYLTQGLLISFGLALICTPSMGLIPQWFRKR 118
+G V + LG + FS L Q+Y T G + G+ S+ ++ +F +R
Sbjct: 77 FGCRVTVMLGGVLASLGMVASSFSHNLSQLYFTAGFITGLGMCFSFQSSITVLGFYFVRR 136
Query: 119 R 119
R
Sbjct: 137 R 137
>Hs5730045 [G] KOG2504 Monocarboxylate transporter
Length = 613
Score = 30.8 bits (68), Expect = 1.2
Identities = 15/69 (21%), Positives = 28/69 (39%)
Query: 50 PVIIYFSRNYGVHVVIGLGIICQCXXXXXXXFSKKLWQIYLTQGLLISFGLALICTPSMG 109
P++ F+ G + G F+ L Y T G+L G + PS+
Sbjct: 233 PIVSIFTDRLGCRITATAGAAVAFIGLHTSSFTSSLSLRYFTYGILFGCGCSFAFQPSLV 292
Query: 110 LIPQWFRKR 118
++ +F++R
Sbjct: 293 ILGHYFQRR 301
>7303562 [G] KOG2504 Monocarboxylate transporter
Length = 596
Score = 30.4 bits (67), Expect = 1.6
Identities = 18/70 (25%), Positives = 30/70 (42%)
Query: 50 PVIIYFSRNYGVHVVIGLGIICQCXXXXXXXFSKKLWQIYLTQGLLISFGLALICTPSMG 109
P+ + + V+ +G I F+ L + LT G+L G L TP +
Sbjct: 28 PLSSALCQRFSCRTVVFVGGIFCAMGMILSYFATSLLHLLLTFGVLTGIGGGLSTTPGIV 87
Query: 110 LIPQWFRKRR 119
++ Q+F K R
Sbjct: 88 IVSQYFDKHR 97
>CE12336 [G] KOG2504 Monocarboxylate transporter
Length = 596
Score = 28.9 bits (63), Expect = 4.7
Identities = 14/71 (19%), Positives = 32/71 (44%)
Query: 50 PVIIYFSRNYGVHVVIGLGIICQCXXXXXXXFSKKLWQIYLTQGLLISFGLALICTPSMG 109
P+ +G V G + + ++ +Y++ GL+ G ++ P++
Sbjct: 95 PIASVLCNVFGCRQVALAGSLIAALGFLLSISAPNIYVLYVSFGLIAGAGFGMMYLPAIV 154
Query: 110 LIPQWFRKRRT 120
+I Q+F K+R+
Sbjct: 155 IISQYFAKKRS 165
>7299667 [G] KOG2504 Monocarboxylate transporter
Length = 571
Score = 28.9 bits (63), Expect = 4.7
Identities = 9/36 (25%), Positives = 22/36 (61%)
Query: 82 SKKLWQIYLTQGLLISFGLALICTPSMGLIPQWFRK 117
++ + +Y T G++ G AL TP++ ++ +F++
Sbjct: 132 TENIGALYFTYGIMFGLGAALAYTPTLAILGHYFKR 167
>SPAC4G9.20c [C] KOG0758 Mitochondrial carnitine-acylcarnitine carrier protein
Length = 302
Score = 28.1 bits (61), Expect = 8.0
Identities = 10/19 (52%), Positives = 14/19 (73%)
Query: 2 YNFCTWGANAGYAVYLATY 20
+ C +GA AGYA++LA Y
Sbjct: 213 WKLCVFGAGAGYAMWLAAY 231
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.328 0.141 0.450
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 8,739,170
Number of Sequences: 60738
Number of extensions: 241612
Number of successful extensions: 467
Number of sequences better than 10.0: 21
Number of HSP's better than 10.0 without gapping: 21
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 443
Number of HSP's gapped (non-prelim): 22
length of query: 196
length of database: 30,389,216
effective HSP length: 101
effective length of query: 95
effective length of database: 24,254,678
effective search space: 2304194410
effective search space used: 2304194410
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.8 bits)