ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactII1386 good F KOG2550 Nucleotide transport and metabolism IMP dehydrogenase/GMP reductase
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactII1386 491324 490224 -367
(367 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YML056c [F] KOG2550 IMP dehydrogenase/GMP reductase 595 e-170
YLR432w [F] KOG2550 IMP dehydrogenase/GMP reductase 595 e-170
YHR216w [F] KOG2550 IMP dehydrogenase/GMP reductase 578 e-165
SPBC2F12.14c [F] KOG2550 IMP dehydrogenase/GMP reductase 455 e-128
Hs4504689 [F] KOG2550 IMP dehydrogenase/GMP reductase 442 e-124
Hs4504687 [F] KOG2550 IMP dehydrogenase/GMP reductase 433 e-121
7291188 [F] KOG2550 IMP dehydrogenase/GMP reductase 431 e-121
Hs18595147 [F] KOG2550 IMP dehydrogenase/GMP reductase 391 e-109
CE17247 [F] KOG2550 IMP dehydrogenase/GMP reductase 324 1e-88
YAR073w [F] KOG2550 IMP dehydrogenase/GMP reductase 319 4e-87
Hs18576335 [F] KOG2550 IMP dehydrogenase/GMP reductase 317 1e-86
Hs18572586 [F] KOG2550 IMP dehydrogenase/GMP reductase 306 3e-83
At1g16350 [F] KOG2550 IMP dehydrogenase/GMP reductase 300 2e-81
At1g79470 [F] KOG2550 IMP dehydrogenase/GMP reductase 292 6e-79
Hs20540918 [F] KOG2550 IMP dehydrogenase/GMP reductase 281 8e-76
YAR075w [F] KOG2550 IMP dehydrogenase/GMP reductase 257 2e-68
Hs17445211 [F] KOG2550 IMP dehydrogenase/GMP reductase 230 3e-60
Hs22049703 [F] KOG2550 IMP dehydrogenase/GMP reductase 215 9e-56
Hs20555980 [F] KOG2550 IMP dehydrogenase/GMP reductase 157 2e-38
Hs18595370 [F] KOG2550 IMP dehydrogenase/GMP reductase 157 2e-38
Hs22044392 [F] KOG2550 IMP dehydrogenase/GMP reductase 139 9e-33
Hs7706109 [F] KOG2550 IMP dehydrogenase/GMP reductase 123 5e-28
Hs20556041 [F] KOG2550 IMP dehydrogenase/GMP reductase 120 4e-27
Hs11321611 [F] KOG2550 IMP dehydrogenase/GMP reductase 117 2e-26
CE09869 [F] KOG2550 IMP dehydrogenase/GMP reductase 109 6e-24
>YML056c [F] KOG2550 IMP dehydrogenase/GMP reductase
Length = 524
Score = 595 bits (1534), Expect = e-170
Identities = 295/366 (80%), Positives = 329/366 (89%)
Query: 2 PGKLLGIVTSRDIQFVEDNSLLVSEIMTKDVVTGKKGITLEEANDILKSTKKGKLPIVDA 61
PGKL+G+VTSRDIQF+ED+SL+VSE+MTK+ VTG KGITL+E N+ILK TKKGKL IVD
Sbjct: 159 PGKLVGLVTSRDIQFLEDDSLVVSEVMTKNPVTGIKGITLKEGNEILKQTKKGKLLIVDD 218
Query: 62 NSTLVSMLSRTDLMKNQSYPLASKSATTKQLLCGAAIGTLDADRERLTXXXXXXXXXXXX 121
N LVSMLSR DLMKNQ+YPLASKSATTKQLLCGAAIGT++AD+ERL
Sbjct: 219 NGNLVSMLSRADLMKNQNYPLASKSATTKQLLCGAAIGTIEADKERLRLLVEAGLDVVIL 278
Query: 122 XSSQGNSIFQLNMLEWIKKTFPDLEVIAGNVVTREQAASLIAAGADGLRIGMGSGSICIT 181
SSQGNS+FQLNM++WIK+TFPDLE+IAGNV TREQAA+LIAAGADGLRIGMGSGSICIT
Sbjct: 279 DSSQGNSVFQLNMIKWIKETFPDLEIIAGNVATREQAANLIAAGADGLRIGMGSGSICIT 338
Query: 182 QEVMACGRPQGTAVYNVTEFANKFGVPCIADGGVQNIGHITKAIALGASTVMMGGMLAGT 241
QEVMACGRPQGTAVYNV +FAN+FGVPC+ADGGVQNIGHITKA+ALG+STVMMGGMLAGT
Sbjct: 339 QEVMACGRPQGTAVYNVCQFANQFGVPCMADGGVQNIGHITKALALGSSTVMMGGMLAGT 398
Query: 242 TESPGEYFYRDGKRLKTYRGMGSVDAMEKTDVKGNAAASRYFSESDKVFVAQGVSGAVVD 301
TESPGEYFY+DGKRLK YRGMGS+DAM+KT KGNA+ SRYFSESD V VAQGVSGAVVD
Sbjct: 399 TESPGEYFYKDGKRLKAYRGMGSIDAMQKTGNKGNASTSRYFSESDSVLVAQGVSGAVVD 458
Query: 302 KGSVKKYIPYLYNGLQHSCQDIGVISLTELREKVDNSEVRFEFRTASAQLEGGINNLHSY 361
KGS+KK+IPYLYNGLQHSCQDIG SLT L+E V N EVRFEFRTASAQLEGG++NLHSY
Sbjct: 459 KGSIKKFIPYLYNGLQHSCQDIGCESLTSLKENVQNGEVRFEFRTASAQLEGGVHNLHSY 518
Query: 362 EKRLHN 367
EKRL+N
Sbjct: 519 EKRLYN 524
>YLR432w [F] KOG2550 IMP dehydrogenase/GMP reductase
Length = 523
Score = 595 bits (1533), Expect = e-170
Identities = 296/365 (81%), Positives = 326/365 (89%)
Query: 3 GKLLGIVTSRDIQFVEDNSLLVSEIMTKDVVTGKKGITLEEANDILKSTKKGKLPIVDAN 62
GKL+GIVTSRDIQFVEDNSLLV ++MTK+ VTG +GITL E N+ILK KKGKL IVD N
Sbjct: 159 GKLMGIVTSRDIQFVEDNSLLVQDVMTKNPVTGAQGITLSEGNEILKKIKKGKLLIVDDN 218
Query: 63 STLVSMLSRTDLMKNQSYPLASKSATTKQLLCGAAIGTLDADRERLTXXXXXXXXXXXXX 122
LVSMLSRTDLMKNQ+YPLASKSATTKQLLCGAAIGT+DAD+ERL
Sbjct: 219 GNLVSMLSRTDLMKNQNYPLASKSATTKQLLCGAAIGTIDADKERLRLLVEAGLDVVILD 278
Query: 123 SSQGNSIFQLNMLEWIKKTFPDLEVIAGNVVTREQAASLIAAGADGLRIGMGSGSICITQ 182
SSQGNSIFQLNM++WIK+TFPDLE+IAGNV TREQAA+LIAAGADGLRIGMGSGSICITQ
Sbjct: 279 SSQGNSIFQLNMIKWIKETFPDLEIIAGNVATREQAANLIAAGADGLRIGMGSGSICITQ 338
Query: 183 EVMACGRPQGTAVYNVTEFANKFGVPCIADGGVQNIGHITKAIALGASTVMMGGMLAGTT 242
EVMACGRPQGTAVYNV EFAN+FG+PC+ADGGVQNIGHITKA+ALG+STVMMGGMLAGTT
Sbjct: 339 EVMACGRPQGTAVYNVCEFANQFGIPCMADGGVQNIGHITKALALGSSTVMMGGMLAGTT 398
Query: 243 ESPGEYFYRDGKRLKTYRGMGSVDAMEKTDVKGNAAASRYFSESDKVFVAQGVSGAVVDK 302
ESPGEYFY+DGKRLK YRGMGS+DAM+KT KGNA+ SRYFSESD V VAQGVSGAVVDK
Sbjct: 399 ESPGEYFYQDGKRLKAYRGMGSIDAMQKTGTKGNASTSRYFSESDSVLVAQGVSGAVVDK 458
Query: 303 GSVKKYIPYLYNGLQHSCQDIGVISLTELREKVDNSEVRFEFRTASAQLEGGINNLHSYE 362
GS+KK+IPYLYNGLQHSCQDIG SLT L+E V + +VRFEFRTASAQLEGG++NLHSYE
Sbjct: 459 GSIKKFIPYLYNGLQHSCQDIGYKSLTLLKENVQSGKVRFEFRTASAQLEGGVHNLHSYE 518
Query: 363 KRLHN 367
KRLHN
Sbjct: 519 KRLHN 523
>YHR216w [F] KOG2550 IMP dehydrogenase/GMP reductase
Length = 523
Score = 578 bits (1491), Expect = e-165
Identities = 286/364 (78%), Positives = 321/364 (87%)
Query: 4 KLLGIVTSRDIQFVEDNSLLVSEIMTKDVVTGKKGITLEEANDILKSTKKGKLPIVDANS 63
KL+G++TSRDIQFVEDNSLLV ++MTK+ VTG +GITL E N+ILK KKG+L +VD
Sbjct: 160 KLVGVITSRDIQFVEDNSLLVQDVMTKNPVTGAQGITLSEGNEILKKIKKGRLLVVDEKG 219
Query: 64 TLVSMLSRTDLMKNQSYPLASKSATTKQLLCGAAIGTLDADRERLTXXXXXXXXXXXXXS 123
LVSMLSRTDLMKNQ+YPLASKSA TKQLLCGA+IGT+DAD+ERL S
Sbjct: 220 NLVSMLSRTDLMKNQNYPLASKSANTKQLLCGASIGTMDADKERLRLLVKAGLDVVILDS 279
Query: 124 SQGNSIFQLNMLEWIKKTFPDLEVIAGNVVTREQAASLIAAGADGLRIGMGSGSICITQE 183
SQGNSIF+LNML+W+K++FP LEVIAGNVVTREQAA+LIAAGADGLRIGMG+GSICITQE
Sbjct: 280 SQGNSIFELNMLKWVKESFPGLEVIAGNVVTREQAANLIAAGADGLRIGMGTGSICITQE 339
Query: 184 VMACGRPQGTAVYNVTEFANKFGVPCIADGGVQNIGHITKAIALGASTVMMGGMLAGTTE 243
VMACGRPQGTAVYNV EFAN+FGVPC+ADGGVQNIGHITKA+ALG+STVMMGGMLAGTTE
Sbjct: 340 VMACGRPQGTAVYNVCEFANQFGVPCMADGGVQNIGHITKALALGSSTVMMGGMLAGTTE 399
Query: 244 SPGEYFYRDGKRLKTYRGMGSVDAMEKTDVKGNAAASRYFSESDKVFVAQGVSGAVVDKG 303
SPGEYFY+DGKRLK YRGMGS+DAM+KT KGNA+ SRYFSESD V VAQGVSGAVVDKG
Sbjct: 400 SPGEYFYQDGKRLKAYRGMGSIDAMQKTGTKGNASTSRYFSESDSVLVAQGVSGAVVDKG 459
Query: 304 SVKKYIPYLYNGLQHSCQDIGVISLTELREKVDNSEVRFEFRTASAQLEGGINNLHSYEK 363
S+KK+IPYLYNGLQHSCQDIG SLT L+ V +VRFEFRTASAQLEGG++NLHSYEK
Sbjct: 460 SIKKFIPYLYNGLQHSCQDIGCRSLTLLKNNVQRGKVRFEFRTASAQLEGGVHNLHSYEK 519
Query: 364 RLHN 367
RLHN
Sbjct: 520 RLHN 523
>SPBC2F12.14c [F] KOG2550 IMP dehydrogenase/GMP reductase
Length = 524
Score = 455 bits (1171), Expect = e-128
Identities = 227/366 (62%), Positives = 287/366 (78%), Gaps = 2/366 (0%)
Query: 3 GKLLGIVTSRDIQFVEDNSLLVSEIMT--KDVVTGKKGITLEEANDILKSTKKGKLPIVD 60
GKL+GIVTSRD+QF +D + V+E+MT ++++T +GI+LE AN++L+ +KKGKLP+VD
Sbjct: 159 GKLVGIVTSRDVQFHKDTNTPVTEVMTPREELITTAEGISLERANEMLRKSKKGKLPVVD 218
Query: 61 ANSTLVSMLSRTDLMKNQSYPLASKSATTKQLLCGAAIGTLDADRERLTXXXXXXXXXXX 120
+ LV++LS TDLMKN +PLASK++ TKQL+ AAIGT D DR RL
Sbjct: 219 KDDNLVALLSLTDLMKNLHFPLASKTSDTKQLMVAAAIGTRDDDRTRLALLAEAGLDAVV 278
Query: 121 XXSSQGNSIFQLNMLEWIKKTFPDLEVIAGNVVTREQAASLIAAGADGLRIGMGSGSICI 180
SSQGNS FQ+ M++WIKKT+P ++VIAGNVVTREQ ASLIAAGADGLR+GMGSGS CI
Sbjct: 279 IDSSQGNSCFQIEMIKWIKKTYPKIDVIAGNVVTREQTASLIAAGADGLRVGMGSGSACI 338
Query: 181 TQEVMACGRPQGTAVYNVTEFANKFGVPCIADGGVQNIGHITKAIALGASTVMMGGMLAG 240
TQEVMACGRPQ TA+ V EFA++FG+ IADGG+QN+GH+ K+++LGA+ VMMGG+LAG
Sbjct: 339 TQEVMACGRPQATAIAQVAEFASQFGIGVIADGGIQNVGHMVKSLSLGATAVMMGGLLAG 398
Query: 241 TTESPGEYFYRDGKRLKTYRGMGSVDAMEKTDVKGNAAASRYFSESDKVFVAQGVSGAVV 300
TTESPGEY+ R+G+R K+YRGMGS+ AME T V NA+ RYFSE+D V VAQGVSG VV
Sbjct: 399 TTESPGEYYVREGQRYKSYRGMGSIAAMEGTGVNKNASTGRYFSENDAVRVAQGVSGLVV 458
Query: 301 DKGSVKKYIPYLYNGLQHSCQDIGVISLTELREKVDNSEVRFEFRTASAQLEGGINNLHS 360
DKGS+ +++PYLY GLQH+ QDIG SL EL E VD EVRFE R+++A EG I +
Sbjct: 459 DKGSLLRFLPYLYTGLQHALQDIGTKSLDELHEAVDKHEVRFELRSSAAIREGDIQGFAT 518
Query: 361 YEKRLH 366
YEKRL+
Sbjct: 519 YEKRLY 524
>Hs4504689 [F] KOG2550 IMP dehydrogenase/GMP reductase
Length = 514
Score = 442 bits (1136), Expect = e-124
Identities = 226/369 (61%), Positives = 290/369 (78%), Gaps = 9/369 (2%)
Query: 1 MPGKLLGIVTSRDIQFV--EDNSLLVSEIMTK--DVVTGKKGITLEEANDILKSTKKGKL 56
M +L+GI++SRDI F+ E++ + EIMTK D+V + ITL+EAN+IL+ +KKGKL
Sbjct: 150 MGSRLVGIISSRDIDFLKEEEHDCFLEEIMTKREDLVVAPRSITLKEANEILQRSKKGKL 209
Query: 57 PIVDANSTLVSMLSRTDLMKNQSYPLASKSATTKQLLCGAAIGTLDADRERLTXXXXXXX 116
PIV+ + LV++++RTDL KN+ YPLASK A KQLLCGAAIGT + D+ RL
Sbjct: 210 PIVNEDDELVAIIARTDLKKNRDYPLASKDAK-KQLLCGAAIGTHEDDKYRLDLLAQAGV 268
Query: 117 XXXXXXSSQGNSIFQLNMLEWIKKTFPDLEVIAGNVVTREQAASLIAAGADGLRIGMGSG 176
SSQGNSIFQ+NM+++IK +P+L+VI GNVVT QA +LI AG D LR+GMGSG
Sbjct: 269 DVVVLDSSQGNSIFQINMIKYIKDKYPNLQVIGGNVVTAAQAKNLIDAGVDALRVGMGSG 328
Query: 177 SICITQEVMACGRPQGTAVYNVTEFANKFGVPCIADGGVQNIGHITKAIALGASTVMMGG 236
SICITQEV+ACGRPQ TAVY V+E+A +FGVP IADGG+QN+GHI KA+ALGASTVMMG
Sbjct: 329 SICITQEVLACGRPQATAVYKVSEYARRFGVPVIADGGIQNVGHIAKALALGASTVMMGS 388
Query: 237 MLAGTTESPGEYFYRDGKRLKTYRGMGSVDAMEKTDVKGNAAASRYFSESDKVFVAQGVS 296
+LA TTE+PGEYF+ DG RLK YRGMGS+DAM+ K ++ +RYFSE+DK+ VAQGVS
Sbjct: 389 LLAATTEAPGEYFFSDGIRLKKYRGMGSLDAMD----KHLSSQNRYFSEADKIKVAQGVS 444
Query: 297 GAVVDKGSVKKYIPYLYNGLQHSCQDIGVISLTELREKVDNSEVRFEFRTASAQLEGGIN 356
GAV DKGS+ K++PYL G+QHSCQDIG SLT++R + + E++FE RT+SAQ+EGG++
Sbjct: 445 GAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVRAMMYSGELKFEKRTSSAQVEGGVH 504
Query: 357 NLHSYEKRL 365
+LHSYEKRL
Sbjct: 505 SLHSYEKRL 513
>Hs4504687 [F] KOG2550 IMP dehydrogenase/GMP reductase
Length = 514
Score = 433 bits (1113), Expect = e-121
Identities = 219/370 (59%), Positives = 284/370 (76%), Gaps = 9/370 (2%)
Query: 1 MPGKLLGIVTSRDIQFV--EDNSLLVSEIMTK--DVVTGKKGITLEEANDILKSTKKGKL 56
M KL+GIVTSRDI F+ +D++ L+SE+MT ++V G+TL+EAN+IL+ +KKGKL
Sbjct: 150 MGSKLVGIVTSRDIDFLAEKDHTTLLSEVMTPRIELVVAPAGVTLKEANEILQRSKKGKL 209
Query: 57 PIVDANSTLVSMLSRTDLMKNQSYPLASKSATTKQLLCGAAIGTLDADRERLTXXXXXXX 116
PIV+ LV++++RTDL KN+ YPLASK + KQLLCGAA+GT + D+ RL
Sbjct: 210 PIVNDCDELVAIIARTDLKKNRDYPLASKDSQ-KQLLCGAAVGTREDDKYRLDLLTQAGV 268
Query: 117 XXXXXXSSQGNSIFQLNMLEWIKKTFPDLEVIAGNVVTREQAASLIAAGADGLRIGMGSG 176
SSQGNS++Q+ M+ +IK+ +P L+VI GNVVT QA +LI AG DGLR+GMG G
Sbjct: 269 DVIVFHSSQGNSVYQIAMVHYIKQKYPHLQVIGGNVVTAAQAKNLIDAGVDGLRVGMGCG 328
Query: 177 SICITQEVMACGRPQGTAVYNVTEFANKFGVPCIADGGVQNIGHITKAIALGASTVMMGG 236
SICITQEVMACGRPQGTAVY V E+A +FGVP IADGG+Q +GH+ KA+ALGASTVMMG
Sbjct: 329 SICITQEVMACGRPQGTAVYKVAEYARRFGVPIIADGGIQTVGHVVKALALGASTVMMGS 388
Query: 237 MLAGTTESPGEYFYRDGKRLKTYRGMGSVDAMEKTDVKGNAAASRYFSESDKVFVAQGVS 296
+LA TTE+PGEYF+ DG RLK YRGMGS+D MEK+ +++ RYFSE DKV +AQGVS
Sbjct: 389 LLAATTEAPGEYFFSDGVRLKKYRGMGSLDPMEKS----SSSQKRYFSEGDKVKIAQGVS 444
Query: 297 GAVVDKGSVKKYIPYLYNGLQHSCQDIGVISLTELREKVDNSEVRFEFRTASAQLEGGIN 356
G++ DKGS++K++PYL G+QH CQDIG SL+ LR + + E++FE RT S Q+EGG++
Sbjct: 445 GSIQDKGSIQKFVPYLIAGIQHGCQDIGARSLSVLRSMMYSGELKFEKRTMSPQIEGGVH 504
Query: 357 NLHSYEKRLH 366
LHSYEKRL+
Sbjct: 505 GLHSYEKRLY 514
>7291188 [F] KOG2550 IMP dehydrogenase/GMP reductase
Length = 537
Score = 431 bits (1108), Expect = e-121
Identities = 223/364 (61%), Positives = 279/364 (76%), Gaps = 2/364 (0%)
Query: 3 GKLLGIVTSRDIQFVEDN-SLLVSEIMTKDVVTGKKGITLEEANDILKSTKKGKLPIVDA 61
GKLLG+VTSRDI F E+ +L+++IMT ++VT GI L AN IL+ +KKGKLPIV+
Sbjct: 174 GKLLGMVTSRDIDFRENQPEVLLADIMTTELVTAPNGINLPTANAILEKSKKGKLPIVNQ 233
Query: 62 NSTLVSMLSRTDLMKNQSYPLASKSATTKQLLCGAAIGTLDADRERLTXXXXXXXXXXXX 121
LV+M++RTDL K +SYP ASK + KQLL GAAIGT D+ RL
Sbjct: 234 AGELVAMIARTDLKKARSYPNASKDSN-KQLLVGAAIGTRSEDKARLALLVANGVDVIIL 292
Query: 122 XSSQGNSIFQLNMLEWIKKTFPDLEVIAGNVVTREQAASLIAAGADGLRIGMGSGSICIT 181
SSQGNS++Q+ M+++IK+T+P+L+VI GNVVTR QA +LI AG DGLR+GMGSGSICIT
Sbjct: 293 DSSQGNSVYQVEMIKYIKETYPELQVIGGNVVTRAQAKNLIDAGVDGLRVGMGSGSICIT 352
Query: 182 QEVMACGRPQGTAVYNVTEFANKFGVPCIADGGVQNIGHITKAIALGASTVMMGGMLAGT 241
QEVMACG PQ TAVY V+ +A +FGVP IADGG+Q+IGHI KAIALGAS VMMG +LAGT
Sbjct: 353 QEVMACGCPQATAVYQVSTYARQFGVPVIADGGIQSIGHIVKAIALGASAVMMGSLLAGT 412
Query: 242 TESPGEYFYRDGKRLKTYRGMGSVDAMEKTDVKGNAAASRYFSESDKVFVAQGVSGAVVD 301
+E+PGEYF+ DG RLK YRGMGS++AME+ D KG A + Y +E DK+ VAQGVSG++VD
Sbjct: 413 SEAPGEYFFSDGVRLKKYRGMGSLEAMERGDAKGAAMSRYYHNEMDKMKVAQGVSGSIVD 472
Query: 302 KGSVKKYIPYLYNGLQHSCQDIGVISLTELREKVDNSEVRFEFRTASAQLEGGINNLHSY 361
KGSV +Y+PYL GLQHSCQDIG S+ +LR+ + N ++RF RT SAQLEG ++ L SY
Sbjct: 473 KGSVLRYLPYLECGLQHSCQDIGANSINKLRDMIYNGQLRFMKRTHSAQLEGNVHGLFSY 532
Query: 362 EKRL 365
EKRL
Sbjct: 533 EKRL 536
>Hs18595147 [F] KOG2550 IMP dehydrogenase/GMP reductase
Length = 509
Score = 391 bits (1005), Expect = e-109
Identities = 198/363 (54%), Positives = 266/363 (72%), Gaps = 6/363 (1%)
Query: 4 KLLGIVTSRDIQFVEDNSLLVSEIMTKDVVTGKKGITLEEANDILKSTKKGKLPIVDANS 63
KL+GI+TSRDI F+ + S + ++V G+T +EAN+IL+ +KKGKLP+V+ +
Sbjct: 153 KLVGILTSRDIDFLAEKDHTPSSVRM-ELVVAPAGVTFKEANEILQRSKKGKLPVVNDHD 211
Query: 64 TLVSMLSRTDLMKNQSYPLASKSATTKQLLCGAAIGTLDADRERLTXXXXXXXXXXXXXS 123
LV++++RTDL KN+ YPLASK + KQLLCGA +GT + D+ RL S
Sbjct: 212 ELVAIIARTDLKKNRDYPLASKDSH-KQLLCGAVVGTCEDDKFRLGLLTQAGVDVIVLDS 270
Query: 124 SQGNSIFQLNMLEWIKKTFPDLEVIAGNVVTREQAASLIAAGADGLRIGMGSGSICITQE 183
SQGNS++Q+ M+ +IK+ +P L+VI NVVT QA +LI AG DGL +GMG GSICIT E
Sbjct: 271 SQGNSVYQIAMVRYIKQKYPHLQVIGRNVVTAAQAKNLIDAGVDGLHVGMGCGSICITLE 330
Query: 184 VMACGRPQGTAVYNVTEFANKFGVPCIADGGVQNIGHITKAIALGASTVMMGGMLAGTTE 243
+MACGR GTAVY V E+A +FGVP IADGG+Q +GH+ KA+ALGASTVMMG +LA TTE
Sbjct: 331 MMACGRTHGTAVYKVAEYAWRFGVPIIADGGIQTVGHVVKALALGASTVMMGSLLATTTE 390
Query: 244 SPGEYFYRDGKRLKTYRGMGSVDAMEKTDVKGNAAASRYFSESDKVFVAQGVSGAVVDKG 303
+ GEYF+ DG LK Y+GMGSVDAMEK+ +++ RYFSE+DKV +QG+ G++ DKG
Sbjct: 391 ASGEYFFSDGVPLKKYQGMGSVDAMEKS----SSSQKRYFSEADKVKFSQGILGSIQDKG 446
Query: 304 SVKKYIPYLYNGLQHSCQDIGVISLTELREKVDNSEVRFEFRTASAQLEGGINNLHSYEK 363
S++K++PYL G+QHSCQDIG SL LR + + E++FE T SAQ+EGG++ LHSYE+
Sbjct: 447 SIQKFVPYLIAGIQHSCQDIGARSLAVLRSMMYSGELKFEKGTVSAQIEGGVHGLHSYER 506
Query: 364 RLH 366
L+
Sbjct: 507 WLY 509
>CE17247 [F] KOG2550 IMP dehydrogenase/GMP reductase
Length = 499
Score = 324 bits (830), Expect = 1e-88
Identities = 180/370 (48%), Positives = 237/370 (63%), Gaps = 33/370 (8%)
Query: 4 KLLGIVTSRDIQFVEDNSLLVSEIMTKDVVTGKKGITLEEANDI-------LKSTKKGKL 56
KL+G+VTSRD F+ + D++ + L ND LK + GKL
Sbjct: 156 KLIGMVTSRDFDFITMDVAGQKGTPISDIMVSVDQLHLGHINDAPELSQKKLKEHRLGKL 215
Query: 57 PIVDANSTLVSMLSRTDLMKNQSYPLASKSATTKQLLCGAAIGTLDADRERLTXXXXXXX 116
PIV+ N L ++L R+DL+K + YP+AS + QLLCGAA+ T + +
Sbjct: 216 PIVNDNGELCALLCRSDLLKARDYPMASYDSKG-QLLCGAAVNTRGESQYTVDRVVEAGV 274
Query: 117 XXXXXXSSQGNSIFQLNMLEWIKKTFPDLEVIAGNVVTREQAASLIAAGADGLRIGMGSG 176
SS G+S +Q++ML +IK+ P ++VIAGNVVTR QA LI GADGLRIGMGSG
Sbjct: 275 DVLIIDSSNGSSTYQISMLRYIKEKHPHVQVIAGNVVTRAQAKLLIDQGADGLRIGMGSG 334
Query: 177 SICITQEVMACGRPQGTAVYNVTEFANKFGVPCIADGGVQNIGHITKAIALGASTVMMGG 236
SICITQ+VMA GR QGTAVY+V +AN+ G+P +ADGG++++G+ITKAI+LGAS VMMGG
Sbjct: 335 SICITQDVMAVGRAQGTAVYDVARYANQRGIPIVADGGIRDVGYITKAISLGASAVMMGG 394
Query: 237 MLAGTTESPGEYFYRDGKRLKTYRGMGSVDAMEKTDVKGNAAASRYFSESDKVFVAQGVS 296
+LA TTE+PGEYF+ G S FSESD++ VAQGVS
Sbjct: 395 LLAATTEAPGEYFWGPG-------------------------GSFNFSESDQIKVAQGVS 429
Query: 297 GAVVDKGSVKKYIPYLYNGLQHSCQDIGVISLTELREKVDNSEVRFEFRTASAQLEGGIN 356
+ D+GS K+IPYL G+QH QDIGV SL + REKVDN V+FE R+ +AQLEGG++
Sbjct: 430 ATMKDRGSCHKFIPYLIRGVQHGMQDIGVRSLRDFREKVDNGIVKFERRSTNAQLEGGVH 489
Query: 357 NLHSYEKRLH 366
+LHS+EKRL+
Sbjct: 490 SLHSFEKRLY 499
>YAR073w [F] KOG2550 IMP dehydrogenase/GMP reductase
Length = 403
Score = 319 bits (818), Expect = 4e-87
Identities = 160/213 (75%), Positives = 182/213 (85%)
Query: 4 KLLGIVTSRDIQFVEDNSLLVSEIMTKDVVTGKKGITLEEANDILKSTKKGKLPIVDANS 63
KL+G +TSRDIQFVEDNSLLV ++MTK+ VTG +GITL E N+ILK KKG+L +VD
Sbjct: 160 KLVGAITSRDIQFVEDNSLLVQDVMTKNPVTGAQGITLSEGNEILKKIKKGRLLVVDEKG 219
Query: 64 TLVSMLSRTDLMKNQSYPLASKSATTKQLLCGAAIGTLDADRERLTXXXXXXXXXXXXXS 123
LVSMLSRTDLMKNQ YPLASKSA TKQLL GA+IGT+DAD+ERL S
Sbjct: 220 NLVSMLSRTDLMKNQKYPLASKSANTKQLLWGASIGTMDADKERLRLLVKAGLDVVILDS 279
Query: 124 SQGNSIFQLNMLEWIKKTFPDLEVIAGNVVTREQAASLIAAGADGLRIGMGSGSICITQE 183
SQGNSIFQLNM++WIK+TFPDLE+IAGNVVT+EQAA+LIAAGADGLRIGMG+GSICITQ+
Sbjct: 280 SQGNSIFQLNMIKWIKETFPDLEIIAGNVVTKEQAANLIAAGADGLRIGMGTGSICITQK 339
Query: 184 VMACGRPQGTAVYNVTEFANKFGVPCIADGGVQ 216
VMACGRPQGTAVYNV EFAN+FGVPC+ADGGVQ
Sbjct: 340 VMACGRPQGTAVYNVCEFANQFGVPCMADGGVQ 372
>Hs18576335 [F] KOG2550 IMP dehydrogenase/GMP reductase
Length = 407
Score = 317 bits (813), Expect = 1e-86
Identities = 176/367 (47%), Positives = 246/367 (66%), Gaps = 31/367 (8%)
Query: 1 MPGKLLGIVTSRDIQFV--EDNSLLVSEIMTKDVVTGKKGITLEEANDILKSTKKGKLPI 58
M KL+GI+TSRD+ F+ ++++ +S +TL+EAN+IL+ KKGKLPI
Sbjct: 70 MGSKLVGIITSRDVDFLAKKEHATFIS-------------VTLKEANEILQRNKKGKLPI 116
Query: 59 VDANSTLVSMLSRTDLMKNQSYPLASKSATTKQLLCGAAIGTLDADRERLTXXXXXXXXX 118
V LV++++RTDL KN+ YPLASK + KQLLC AA+GT + D L
Sbjct: 117 VSDRDELVAIIARTDLKKNRDYPLASKDSH-KQLLCRAAVGTREDDECHLDLLTQAGVNV 175
Query: 119 XXXXSSQGNSIFQLNMLEWIKKTFPDLEVIAGNVVTREQAASLIAAGADGLRIGMGSGSI 178
SSQG+S++Q+ M+ +IK+ +P L+VI GNVVT QA +L+ A DGL +GMG GSI
Sbjct: 176 VVLDSSQGSSVYQITMVHYIKQKYPHLQVIGGNVVTAAQAKNLMDARVDGLHVGMGYGSI 235
Query: 179 CITQEVMACGRPQGTAVYNVTEFANKFGVPCIADGGVQNIGHITKAIALGASTVMMGGML 238
CITQ+VMACG PQGTAVY V ++A F D G + G ++ G +L
Sbjct: 236 CITQKVMACGWPQGTAVYKVAKYAQCF------DCGARGQGPGPWSLHSDD-----GLLL 284
Query: 239 AGTTESPGEYFYRDGKRLKTYRGMGSVDAMEKTDVKGNAAASRYFSESDKVFVAQGVSGA 298
A TTE+PGEYF+ + +LK Y+GMGS+DAMEK+ +++ RYFS+ DKV +AQGVSG+
Sbjct: 285 ATTTEAPGEYFFLERVQLKKYQGMGSLDAMEKS----SSSQKRYFSKGDKVKIAQGVSGS 340
Query: 299 VVDKGSVKKYIPYLYNGLQHSCQDIGVISLTELREKVDNSEVRFEFRTASAQLEGGINNL 358
+ DKGS++K++PYL G+QHSCQDIG SL+ L + + E++FE +T SAQ++GG++ L
Sbjct: 341 IQDKGSIQKFVPYLIAGIQHSCQDIGARSLSVLWSMMYSGELKFEKQTMSAQIKGGVHGL 400
Query: 359 HSYEKRL 365
HSYEK+L
Sbjct: 401 HSYEKQL 407
>Hs18572586 [F] KOG2550 IMP dehydrogenase/GMP reductase
Length = 431
Score = 306 bits (784), Expect = 3e-83
Identities = 166/324 (51%), Positives = 226/324 (69%), Gaps = 30/324 (9%)
Query: 1 MPGKLLGIVTSRDIQFV--EDNSLLVSEIMTK--DVVTGKKGITLEEANDILKSTKKGKL 56
M KL+GIVTSRDI F+ +D++ L+SE+MT ++V +TL+EAN+IL+ +KKGKL
Sbjct: 134 MGSKLVGIVTSRDINFLAEKDHTTLLSEVMTPRLELVVAPACVTLKEANEILQRSKKGKL 193
Query: 57 PIVDANSTLVSMLSRTDLMKNQSYPLASKSATTKQLLCGAAIGTLDADRERLTXXXXXXX 116
PI++ + LV++++ +DL KNQ YPLASK + + G I LD
Sbjct: 194 PIINDRNELVAIITGSDLKKNQDYPLASKDSQQAAAV-GVDIIVLD-------------- 238
Query: 117 XXXXXXSSQGNSIFQLNMLEWIKKTFPDLEVIAGNVVTREQAASLIAAGADGLRIGMGSG 176
SSQGN ++Q+ M+ +IK+ +P L+VI NVVT QA +LI AG DGL +GMG G
Sbjct: 239 ------SSQGNLVYQIAMVHYIKQKYPHLQVIGRNVVTAAQAKNLIDAGVDGLCVGMGCG 292
Query: 177 SICITQEVMACGRPQGTAVYNVTEFANKFGVPCIADGGVQNIGHITKAIALGASTVMMGG 236
SIC+T+EVMACG+PQGTAVY ++A +FGVP IA+G +Q +GHI KA+ALG STVMMG
Sbjct: 293 SICVTREVMACGQPQGTAVYKEAKYARRFGVPIIANGSIQTMGHIVKALALGVSTVMMGS 352
Query: 237 MLAGTTESPGEYFYRDGKRLKTYRGMGSVDAMEKTDVKGNAAASRYFSESDKVFVAQGVS 296
+LA T E+PGEYF D RLK Y GMGS+DAMEK+ +++ RYFS+ DKV + QGV
Sbjct: 353 LLAITMEAPGEYF-SDEVRLKKYWGMGSLDAMEKS----SSSQKRYFSKGDKVKIVQGVL 407
Query: 297 GAVVDKGSVKKYIPYLYNGLQHSC 320
G++ DKGS++K++PYL G+QH C
Sbjct: 408 GSIQDKGSIQKFVPYLIVGIQHGC 431
>At1g16350 [F] KOG2550 IMP dehydrogenase/GMP reductase
Length = 502
Score = 300 bits (768), Expect = 2e-81
Identities = 165/371 (44%), Positives = 235/371 (62%), Gaps = 20/371 (5%)
Query: 4 KLLGIVTSRDIQFVEDNSLLVSEIMTKDVVTGKKG--------ITLEEANDILKSTKKGK 55
KLLG V+ + ++D+ E+ D + + I L++ +L+ +KG
Sbjct: 140 KLLGYVSKSEWSSMKDDQ---KEVKIYDYMKSCENKDYYVPWDIDLDKIEAVLEDKQKGF 196
Query: 56 LPIVDANSTLVSMLSRTDLMKNQSYPLASKSAT--TKQLLCGAAIGTLDADRERLTXXXX 113
+ +++ V+++++ D+ + + YP K+ + GAAIGT ++D+ERL
Sbjct: 197 V-VLEKEGETVNVVTKDDVERVKGYPKLGSGTVGADKKWMVGAAIGTRESDKERLEHLVK 255
Query: 114 XXXXXXXXXSSQGNSIFQLNMLEWIKKTFPDLEVIAGNVVTREQAASLIAAGADGLRIGM 173
SSQGNSI+QL M++++K T+P+L+V+ GNVVT QA +LI AG DGLR+GM
Sbjct: 256 AGANVVVLDSSQGNSIYQLEMIKYVKNTYPELDVVGGNVVTMYQAENLIKAGVDGLRVGM 315
Query: 174 GSGSICITQEVMACGRPQGTAVYNVTEFANKFGVPCIADGGVQNIGHITKAIALGASTVM 233
GSGSIC TQEV A GR Q TAVY V+ A + GVP IADGG+ N GHI KA+ LGASTVM
Sbjct: 316 GSGSICTTQEVCAVGRGQATAVYKVSTLAAQHGVPVIADGGISNSGHIVKALVLGASTVM 375
Query: 234 MGGMLAGTTESPGEYFYRDGKRLKTYRGMGSVDAMEKTDVKGNAAASRYFSESDKVFVAQ 293
MG LAG+TE+PG Y YR+G+R+K YRGMGS++AM K + RY ++ K+ +AQ
Sbjct: 376 MGSFLAGSTEAPGAYEYRNGRRVKKYRGMGSLEAMTK------GSDQRYLGDTAKLKIAQ 429
Query: 294 GVSGAVVDKGSVKKYIPYLYNGLQHSCQDIGVISLTELREKVDNSEVRFEFRTASAQLEG 353
GV GAV DKGSV K+IPY + ++ QD+G SL E + ++ +R E RT +AQ+EG
Sbjct: 430 GVVGAVADKGSVLKFIPYTMHAVKQGFQDLGASSLQSAHELLRDNTLRLEARTGAAQIEG 489
Query: 354 GINNLHSYEKR 364
GI+ L SYEK+
Sbjct: 490 GIHGLVSYEKK 500
>At1g79470 [F] KOG2550 IMP dehydrogenase/GMP reductase
Length = 503
Score = 292 bits (747), Expect = 6e-79
Identities = 155/328 (47%), Positives = 215/328 (65%), Gaps = 9/328 (2%)
Query: 39 ITLEEANDILKSTKKGKLPIVDANSTLVSMLSRTDLMKNQSYPLASKSATTK--QLLCGA 96
I E+ +L+ +KG + +++ + V+++++ D+ + + YP + + + GA
Sbjct: 181 IDFEKLEFVLEDKQKGFV-VLERDGETVNVVTKDDIQRVKGYPKSGPGTVGPDGEWMVGA 239
Query: 97 AIGTLDADRERLTXXXXXXXXXXXXXSSQGNSIFQLNMLEWIKKTFPDLEVIAGNVVTRE 156
AIGT ++D+ERL SSQGNSI+QL M++++KKT+P+L+VI GNVVT
Sbjct: 240 AIGTRESDKERLEHLVNVGVNAVVLDSSQGNSIYQLEMIKYVKKTYPELDVIGGNVVTMY 299
Query: 157 QAASLIAAGADGLRIGMGSGSICITQEVMACGRPQGTAVYNVTEFANKFGVPCIADGGVQ 216
QA +LI AG DGLR+GMGSGSIC TQEV A GR Q TAVY V A + G+P IADGG+
Sbjct: 300 QAQNLIQAGVDGLRVGMGSGSICTTQEVCAVGRGQATAVYKVCSIAAQSGIPVIADGGIS 359
Query: 217 NIGHITKAIALGASTVMMGGMLAGTTESPGEYFYRDGKRLKTYRGMGSVDAMEKTDVKGN 276
N GHI KA+ LGASTVMMG LAG+TE+PG Y Y +GKR+K YRGMGS++AM K
Sbjct: 360 NSGHIVKALVLGASTVMMGSFLAGSTEAPGGYEYTNGKRIKKYRGMGSLEAMTK------ 413
Query: 277 AAASRYFSESDKVFVAQGVSGAVVDKGSVKKYIPYLYNGLQHSCQDIGVISLTELREKVD 336
+ RY + K+ +AQGV GAV DKGSV K IPY + ++ QD+G SL +
Sbjct: 414 GSDQRYLGDQTKLKIAQGVVGAVADKGSVLKLIPYTMHAVKQGFQDLGASSLQSAHGLLR 473
Query: 337 NSEVRFEFRTASAQLEGGINNLHSYEKR 364
++ +R E RT +AQ+EGG++ L SYEK+
Sbjct: 474 SNILRLEARTGAAQVEGGVHGLVSYEKK 501
>Hs20540918 [F] KOG2550 IMP dehydrogenase/GMP reductase
Length = 428
Score = 281 bits (720), Expect = 8e-76
Identities = 145/285 (50%), Positives = 197/285 (68%), Gaps = 9/285 (3%)
Query: 82 LASKSATTKQLLCGAAIGTLDADRERLTXXXXXXXXXXXXXSSQGNSIFQLNMLEWIKKT 141
+ SK + KQLLCGAA+GT + D+ RL SQGNS++Q+ M+ +IK+
Sbjct: 153 MGSKLDSHKQLLCGAAVGTREDDKYRLDLLTQVGVDVIVLDLSQGNSLYQMAMVYYIKQK 212
Query: 142 FPDLEVIAGNVVTREQAASLIAAGADGLRIGMGSGSICITQEVMACGRPQGTAVYNVTEF 201
+P L+VI GN+VT QA +LI AG +GL +GMG SICITQEVMA PQGTAVY V E+
Sbjct: 213 YPHLQVIGGNMVTAAQAKNLIDAGVEGLHVGMGCSSICITQEVMAYSWPQGTAVYKVAEY 272
Query: 202 ANKFGVPCIADGGVQNIGHITKAIALGASTVMMGGMLAGTTESPGEYFYRDGKRLKTYRG 261
A F A+GG+Q +G++ KA+ALGASTVMMG +LA TTE P +YF+ DG LK YRG
Sbjct: 273 ARHF-----ANGGIQTMGNMVKALALGASTVMMGSLLAATTEVPSKYFFSDGVWLKKYRG 327
Query: 262 MGSVDAMEKTDVKGNAAASRYFSESDKVFVAQGVSGAVVDKGSVKKYIPYLYNGLQHSCQ 321
MGS+DA+EK+ + + +YF E DK+ +AQGVS ++ DKGS++K++ YL G+QH CQ
Sbjct: 328 MGSLDALEKS----SGSQKQYFMEGDKLKIAQGVSSSIQDKGSIQKFVSYLIAGIQHGCQ 383
Query: 322 DIGVISLTELREKVDNSEVRFEFRTASAQLEGGINNLHSYEKRLH 366
D GV +L+ L + + E +FE T AQ++GG+ LHSY+KRL+
Sbjct: 384 DTGVCNLSVLLSMMYSGERKFEKWTMLAQIKGGVQGLHSYKKRLY 428
>YAR075w [F] KOG2550 IMP dehydrogenase/GMP reductase
Length = 157
Score = 257 bits (656), Expect = 2e-68
Identities = 126/153 (82%), Positives = 139/153 (90%), Gaps = 1/153 (0%)
Query: 216 QNIGHI-TKAIALGASTVMMGGMLAGTTESPGEYFYRDGKRLKTYRGMGSVDAMEKTDVK 274
+NIGHI TKA+ALG+STVMMGGMLAGTTESPGEY Y+DGKRLK YRGMGS+DAM+KT K
Sbjct: 5 KNIGHIITKALALGSSTVMMGGMLAGTTESPGEYLYQDGKRLKAYRGMGSIDAMQKTGTK 64
Query: 275 GNAAASRYFSESDKVFVAQGVSGAVVDKGSVKKYIPYLYNGLQHSCQDIGVISLTELREK 334
GNA+ SRYFSESD V VAQGVSGAVVDKGS+KK+IPYLYNGLQHSCQDIG SLT L+E
Sbjct: 65 GNASTSRYFSESDSVLVAQGVSGAVVDKGSIKKFIPYLYNGLQHSCQDIGCRSLTLLKEN 124
Query: 335 VDNSEVRFEFRTASAQLEGGINNLHSYEKRLHN 367
V + +VRFEFRTASAQLEGG+NNLHSYEKRLHN
Sbjct: 125 VQSGKVRFEFRTASAQLEGGVNNLHSYEKRLHN 157
>Hs17445211 [F] KOG2550 IMP dehydrogenase/GMP reductase
Length = 448
Score = 230 bits (586), Expect = 3e-60
Identities = 138/299 (46%), Positives = 179/299 (59%), Gaps = 11/299 (3%)
Query: 64 TLVSMLSRTD--LMKNQSYPLASKSATTKQLLCGAAIGTLDADRERLTXXXXXXXXXXXX 121
TL +L RT KN+ YPLASK + KQLLC AA+GT + D+ L
Sbjct: 159 TLTFLLRRTTPPSSKNRDYPLASKDSH-KQLLCRAAVGTREDDKYCLDLLFQAGLNSWTR 217
Query: 122 XSSQGNSIFQLNMLEWIKKTFPDLEVIAGNVVTREQAASLIAAGADGLRIGMGSGSICIT 181
G S L K P + + Q AG DGL +G G GSICIT
Sbjct: 218 PRELGTSDHH-GALHQTKVPPPPGDWGEHGDSSPGQEPD---AGVDGLLVGTGCGSICIT 273
Query: 182 QEVMACGRPQGTAVYNVTEFANKFGVPCIADGGVQNIGHITKAIALGASTVMMGGMLAGT 241
QEVMACGRPQGTA+Y V E+A FGVP I +GG+Q + H+ KA+ALGASTVM G +LA T
Sbjct: 274 QEVMACGRPQGTAMYKVAEYAWHFGVPIIFNGGIQIVEHMVKALALGASTVMTGSLLAAT 333
Query: 242 TESPGEYFYRDGKRLKTYRGMGSVDAMEKTDVKGNAAASRYFSESDKVFVAQGVSGAVVD 301
E+PGEYF+ DG LK YRGMGS+DAM K+ +++ RYF E DKV +AQ VS ++ D
Sbjct: 334 MEAPGEYFFSDGVWLKKYRGMGSLDAMGKS----SSSQKRYFGEGDKVKIAQDVSNSIQD 389
Query: 302 KGSVKKYIPYLYNGLQHSCQDIGVISLTELREKVDNSEVRFEFRTASAQLEGGINNLHS 360
KGS++ ++ YL +Q CQD SL+ L + + E++FE T AQ++GG++ LHS
Sbjct: 390 KGSIQNFVSYLIVDIQQGCQDSRAHSLSALWSMMYSGELKFEKWTILAQIKGGVHGLHS 448
>Hs22049703 [F] KOG2550 IMP dehydrogenase/GMP reductase
Length = 575
Score = 215 bits (547), Expect = 9e-56
Identities = 139/356 (39%), Positives = 196/356 (55%), Gaps = 77/356 (21%)
Query: 1 MPGKLLGIVTSRDIQFV--EDNSLLVSEIMTK--DVVTGKKGITLEEANDILKSTKKGKL 56
M K +GIVTSRDI F+ +D++ L+SE+M ++V G+ L+EAN+IL+ +KK KL
Sbjct: 159 MGSKPVGIVTSRDIDFLAEKDHTTLLSEVMMPRIELVVAPAGVMLKEANEILQQSKKVKL 218
Query: 57 PIVDANSTLVSMLSRTDLMKNQSYPLASKSATTKQLLCGAAIGTLDADRERLTXXXXXXX 116
PIV+ + LV++++ TDL KN+ YP+ASK + +QLLCGAA+GT R L
Sbjct: 219 PIVNDDDELVAIIALTDL-KNRDYPVASKDSH-EQLLCGAAVGTCGCRRHSLGLVRRELA 276
Query: 117 XXXXXXSSQGNSIFQLNMLEWIKKTFPDLEVIAGNVVTREQAASLIAAGADGLRIGMGSG 176
M+ ++K+ + L+VI GNVVT QA +LI AG
Sbjct: 277 VSTA-------------MVYYVKQKYSHLQVIGGNVVTAAQAKNLIDAGH---------- 313
Query: 177 SICITQEVMACGRPQGTAVYNVTEFANKFGVPCIADGGVQNIGHITKAIALGASTVMMGG 236
VY V E+A FGVP IADGG+ +GH+
Sbjct: 314 -----------------CVYKVAEYARHFGVPIIADGGILTVGHVK-------------- 342
Query: 237 MLAGTTESPGEYFYRDGKRLKTYRGMGSVDAMEKTDVKGNAAASRYFSESDKVFVAQGVS 296
+ DG RLK Y G G +DAMEK+ +++ +RYFSE DKV + QGVS
Sbjct: 343 -------------FSDGVRLKKYWGTGLLDAMEKS----SSSQARYFSEEDKVKITQGVS 385
Query: 297 GAVVDKGSVKKYIPYLYNGLQHSCQDIGVISLTELREKVDNSEVRFEFRTASAQLE 352
G++ DKGS++K++PYL G+QH CQDI SL+ L + + E++FE RT SAQ+E
Sbjct: 386 GSIQDKGSIQKFVPYLIVGIQHGCQDIRARSLSVLWSMMYSGELKFEKRTMSAQIE 441
>Hs20555980 [F] KOG2550 IMP dehydrogenase/GMP reductase
Length = 425
Score = 157 bits (398), Expect = 2e-38
Identities = 128/374 (34%), Positives = 183/374 (48%), Gaps = 94/374 (25%)
Query: 1 MPGKLLGIVTSRDIQFV--EDNSLLVSEIMTK--DVVTGKKGITLEEANDILKSTKKGKL 56
M KL+GI+TS DI F+ +D++ L+SE+M ++V G+ L+EAN+IL+ +KKGKL
Sbjct: 138 MGSKLVGIITSADINFLAEKDHNTLLSEVMMPRIELVVAPAGVMLKEANEILQRSKKGKL 197
Query: 57 PIVDANSTLVSMLSRTDLMKNQSYPLASKSATTKQLL----CGAAIGTLDADRERLTXXX 112
PIV+ LV++++ TDL KN+ YPLASK + +QLL AA+GT + + L
Sbjct: 198 PIVNDLDELVAIIACTDLKKNRDYPLASKD-SHEQLLWHIHIYAAVGTHEDGKYCLDLLT 256
Query: 113 XXXXXXXXXXSSQGNSIFQLNMLEWIKKTFPDLEVIAGNVVTREQAASLIAAGADGLRIG 172
SSQGNS ++ Q G+DGLR
Sbjct: 257 QAGDDFIILDSSQGNS------------------SVSDRHSALHQTEVPQPPGSDGLRSA 298
Query: 173 MGSGSICITQEVMACGRPQGTAVYNVTEFANKFGVPCIADGGVQNIGHITKAIALGASTV 232
G C Q C P + + + H+ KA+ LGASTV
Sbjct: 299 PGH---CCVQGGQVC--------------------PTLWCAHHRTVEHVVKALELGASTV 335
Query: 233 MMGGMLAGTTESPGEYFYRDGKRLKTYRGMGSVDAMEKTDVKGNAAASRYFSESDKVFVA 292
MMG +LA TE+P +YF DGK ++GMGS+DAMEK+ +++ +YFSE DKV +
Sbjct: 336 MMGCLLAAITEAPCKYF-SDGK----HQGMGSLDAMEKS----SSSQKQYFSEGDKVKIT 386
Query: 293 QGVSGAVVDKGSVKKYIPYLYNGLQHSCQDIGVISLTELREKVDNSEVRFEFRTASAQLE 352
QGVS ++ KG +K FE +T AQ+E
Sbjct: 387 QGVSCSIQYKGGLK-----------------------------------FEKQTVLAQIE 411
Query: 353 GGINNLHSYEKRLH 366
GG++ L S+EKRL+
Sbjct: 412 GGVHGLCSHEKRLY 425
>Hs18595370 [F] KOG2550 IMP dehydrogenase/GMP reductase
Length = 341
Score = 157 bits (397), Expect = 2e-38
Identities = 104/277 (37%), Positives = 141/277 (50%), Gaps = 82/277 (29%)
Query: 4 KLLGIVTSRDIQFV-EDNSLLVSEIMTKDVVTGKKGITLEEANDILKSTKKGKLPIVDAN 62
KL+GI+ SRDI F+ E +++L+SE+MT
Sbjct: 133 KLVGIIASRDIDFLAEKDTILLSEMMTP-------------------------------- 160
Query: 63 STLVSMLSRTDLMKNQSYPLASKSATTKQLLCGAAIGTLDADRERLTXXXXXXXXXXXXX 122
RT+L + KQLLCGA +GT + D+ L
Sbjct: 161 --------RTELDFH------------KQLLCGAVVGTREDDKFCLDLLTQAGVDVIVLD 200
Query: 123 SSQGNSIFQLNMLEWIKKTFPDLEVIAGNVVTREQAASLIAAGADGLRIGMGSGSICITQ 182
SSQGNS++Q+ + +IK+ + L+ + +GMG GSICIT
Sbjct: 201 SSQGNSVYQIATVHYIKQKYLHLQQPS---------------------VGMGCGSICITG 239
Query: 183 EVMACGRPQGTAVYNVTEFANKFGVPCIADGGVQNIGHITKA--------IALGASTVMM 234
EVMACG+ GTAVY V E+ +FGVP IADG +Q +G++ KA +ALGASTVM
Sbjct: 240 EVMACGQTHGTAVYKVAEYVWRFGVPVIADGSIQTVGYMVKALALGASTVLALGASTVMT 299
Query: 235 GGMLAGTTESPGEYFYRDGKRLKTYRGMGSVDAMEKT 271
G +LA TTE+ GEYF+ D L+ YRGMGS+DAMEK+
Sbjct: 300 GSLLAATTEASGEYFFSDRVWLRKYRGMGSLDAMEKS 336
>Hs22044392 [F] KOG2550 IMP dehydrogenase/GMP reductase
Length = 287
Score = 139 bits (349), Expect = 9e-33
Identities = 76/141 (53%), Positives = 95/141 (66%), Gaps = 4/141 (2%)
Query: 75 MKNQSYPLASKSATTKQLLCGAAIGTLDADRERLTXXXXXXXXXXXXXSSQGNSIFQLNM 134
+KN+ YPLASK + KQLL GAA+GT + D+ RL SQGNS++Q+
Sbjct: 151 LKNRDYPLASKDSH-KQLLRGAAVGTPEDDKYRLDLLTQAGVDVVVLDLSQGNSVYQIAT 209
Query: 135 LEWIKKTFPDLEVIAGNVVTREQAASLIAAGADGLRIGMGSGSICITQEVMACGRPQGTA 194
+ +IK+ +P L+VI +T QA +LI A DGLRIGMG GSICITQEVMACG PQGTA
Sbjct: 210 VHYIKQKYPHLQVIG---MTAAQAKNLIDAAVDGLRIGMGCGSICITQEVMACGGPQGTA 266
Query: 195 VYNVTEFANKFGVPCIADGGV 215
+Y V E+A FGV IADGG+
Sbjct: 267 LYKVAEYALCFGVSIIADGGI 287
>Hs7706109 [F] KOG2550 IMP dehydrogenase/GMP reductase
Length = 348
Score = 123 bits (308), Expect = 5e-28
Identities = 76/211 (36%), Positives = 112/211 (53%), Gaps = 11/211 (5%)
Query: 124 SQGNSIFQLNMLEWIKKTFPDLEVIAGNVVTREQAASLIAAGADGLRIGMGSGSICITQE 183
+ G S + ++ ++K FP ++AGNVVT E LI +GAD +++G+G GS+C T++
Sbjct: 131 ANGYSEHFVEFVKDVRKRFPQHTIMAGNVVTGEMVEELILSGADIIKVGIGPGSVCTTRK 190
Query: 184 VMACGRPQGTAVYNVTEFANKFGVPCIADGGVQNIGHITKAIALGASTVMMGGMLAGTTE 243
G PQ +AV + A+ I+DGG G + KA GA VM+GGMLAG +E
Sbjct: 191 KTGVGYPQLSAVMECADAAHGLKGHIISDGGCSCPGDVAKAFGAGADFVMLGGMLAGHSE 250
Query: 244 SPGEYFYRDGKRLKTYRGMGSVDAMEKTDVKGNAAASRYFSESDKVFVAQGVSGAVVDKG 303
S GE RDGK+ K + GM S AM+K G A R ++G + V KG
Sbjct: 251 SGGELIERDGKKYKLFYGMSSEMAMKK--YAGGVAEYR---------ASEGKTVEVPFKG 299
Query: 304 SVKKYIPYLYNGLQHSCQDIGVISLTELREK 334
V+ I + G++ +C +G L EL +
Sbjct: 300 DVEHTIRDILGGIRSTCTYVGAAKLKELSRR 330
>Hs20556041 [F] KOG2550 IMP dehydrogenase/GMP reductase
Length = 345
Score = 120 bits (300), Expect = 4e-27
Identities = 74/211 (35%), Positives = 110/211 (52%), Gaps = 11/211 (5%)
Query: 124 SQGNSIFQLNMLEWIKKTFPDLEVIAGNVVTREQAASLIAAGADGLRIGMGSGSICITQE 183
+ G S + ++ ++ FP+ ++AGNVVT E LI +GAD +++G+G GS+C T+
Sbjct: 131 ANGYSEHFVEFVKLVRAKFPEHTIMAGNVVTGEMVEELILSGADIIKVGVGPGSVCTTRT 190
Query: 184 VMACGRPQGTAVYNVTEFANKFGVPCIADGGVQNIGHITKAIALGASTVMMGGMLAGTTE 243
G PQ +AV + A+ I+DGG G + KA GA VM+GGM +G TE
Sbjct: 191 KTGVGYPQLSAVIECADSAHGLKGHIISDGGCTCPGDVAKAFGAGADFVMLGGMFSGHTE 250
Query: 244 SPGEYFYRDGKRLKTYRGMGSVDAMEKTDVKGNAAASRYFSESDKVFVAQGVSGAVVDKG 303
GE F R+G++LK + GM S AM K G A R ++G + V KG
Sbjct: 251 CAGEVFERNGRKLKLFYGMSSDTAMNKH--AGGVAEYR---------ASEGKTVEVPYKG 299
Query: 304 SVKKYIPYLYNGLQHSCQDIGVISLTELREK 334
V+ I + GL+ +C +G L EL +
Sbjct: 300 DVENTILDILGGLRSTCTYVGAAKLKELSRR 330
>Hs11321611 [F] KOG2550 IMP dehydrogenase/GMP reductase
Length = 345
Score = 117 bits (294), Expect = 2e-26
Identities = 73/211 (34%), Positives = 109/211 (51%), Gaps = 11/211 (5%)
Query: 124 SQGNSIFQLNMLEWIKKTFPDLEVIAGNVVTREQAASLIAAGADGLRIGMGSGSICITQE 183
+ G S + ++ ++ FP+ ++AGNVVT E LI +GAD +++G+G GS+C T+
Sbjct: 131 ANGYSEHFVEFVKLVRAKFPEHTIMAGNVVTGEMVEELILSGADIIKVGVGPGSVCTTRT 190
Query: 184 VMACGRPQGTAVYNVTEFANKFGVPCIADGGVQNIGHITKAIALGASTVMMGGMLAGTTE 243
G PQ +AV + A+ I+DGG G + KA GA VM+GGM +G TE
Sbjct: 191 KTGVGYPQLSAVIECADSAHGLKGHIISDGGCTCPGDVAKAFGTGADFVMLGGMFSGHTE 250
Query: 244 SPGEYFYRDGKRLKTYRGMGSVDAMEKTDVKGNAAASRYFSESDKVFVAQGVSGAVVDKG 303
GE R+G++LK + GM S AM K G A R ++G + V KG
Sbjct: 251 CAGEVIERNGRKLKLFYGMSSDTAMNKH--AGGVAEYR---------ASEGKTVEVPYKG 299
Query: 304 SVKKYIPYLYNGLQHSCQDIGVISLTELREK 334
V+ I + GL+ +C +G L EL +
Sbjct: 300 DVENTILDILGGLRSTCTYVGAAKLKELSRR 330
>CE09869 [F] KOG2550 IMP dehydrogenase/GMP reductase
Length = 358
Score = 109 bits (273), Expect = 6e-24
Identities = 65/211 (30%), Positives = 109/211 (50%), Gaps = 11/211 (5%)
Query: 124 SQGNSIFQLNMLEWIKKTFPDLEVIAGNVVTREQAASLIAAGADGLRIGMGSGSICITQE 183
+ G S + + +++ +P ++AGNVVT E LI +GAD +++G+G GS+C T++
Sbjct: 132 ANGYSESFVEFIRRVREAYPKHTIMAGNVVTGEMVEELILSGADIVKVGIGPGSVCTTRK 191
Query: 184 VMACGRPQGTAVYNVTEFANKFGVPCIADGGVQNIGHITKAIALGASTVMMGGMLAGTTE 243
G PQ +AV + A+ ++DGG N G + KA GA VM+GG+ AG +
Sbjct: 192 KAGVGYPQLSAVLECADAAHGLNGHVMSDGGCSNPGDVAKAFGAGADFVMIGGLFAGHDQ 251
Query: 244 SPGEYFYRDGKRLKTYRGMGSVDAMEKTDVKGNAAASRYFSESDKVFVAQGVSGAVVDKG 303
S G+ +GK+ K + GM S AM+K G+ A R ++G + + +G
Sbjct: 252 SGGDLIEHNGKKFKLFYGMSSDTAMKKH--HGSVAEYR---------ASEGKTVTIPYRG 300
Query: 304 SVKKYIPYLYNGLQHSCQDIGVISLTELREK 334
V + + G++ +C G L EL ++
Sbjct: 301 DVNGTVQDILGGIRSACTYTGAKHLKELAKR 331
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.315 0.133 0.368
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,921,697
Number of Sequences: 60738
Number of extensions: 728942
Number of successful extensions: 1927
Number of sequences better than 1.0e-05: 25
Number of HSP's better than 0.0 without gapping: 25
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 1852
Number of HSP's gapped (non-prelim): 29
length of query: 367
length of database: 30,389,216
effective HSP length: 108
effective length of query: 259
effective length of database: 23,829,512
effective search space: 6171843608
effective search space used: 6171843608
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)