ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactII1599 good R KOG3508 General function prediction only GTPase-activating protein
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactII1599 574073 570936 -1046
(1046 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YKL092c [R] KOG3508 GTPase-activating protein 734 0.0
Hs4758808 [R] KOG3508 GTPase-activating protein 141 6e-33
CE23475 [R] KOG3508 GTPase-activating protein 135 3e-31
CE23474 [R] KOG3508 GTPase-activating protein 135 3e-31
CE23473 [R] KOG3508 GTPase-activating protein 135 3e-31
CE23472 [R] KOG3508 GTPase-activating protein 135 3e-31
CE23471 [R] KOG3508 GTPase-activating protein 135 3e-31
CE23470 [R] KOG3508 GTPase-activating protein 135 3e-31
Hs4506431 [R] KOG3508 GTPase-activating protein 127 9e-29
Hs12545406 [R] KOG3508 GTPase-activating protein 127 9e-29
CE28277 [R] KOG3508 GTPase-activating protein 125 5e-28
Hs20070109 [R] KOG3508 GTPase-activating protein 124 6e-28
7293383 [R] KOG3508 GTPase-activating protein 123 2e-27
7293174 [R] KOG3508 GTPase-activating protein 119 3e-26
Hs20546119 [R] KOG3508 GTPase-activating protein 115 4e-25
Hs22060041 [R] KOG3508 GTPase-activating protein 106 2e-22
Hs4759026 [T] KOG2059 Ras GTPase-activating protein 100 1e-20
Hs5901958 [T] KOG2059 Ras GTPase-activating protein 94 1e-18
Hs12545410 [T] KOG2059 Ras GTPase-activating protein 89 3e-17
7301417 [V] KOG1826 Ras GTPase activating protein RasGAP/neurofi... 89 3e-17
7294865 [T] KOG2059 Ras GTPase-activating protein 89 4e-17
Hs4557793 [V] KOG1826 Ras GTPase activating protein RasGAP/neuro... 83 2e-15
Hs12545408 [T] KOG2059 Ras GTPase-activating protein 77 1e-13
CE05002 [T] KOG2059 Ras GTPase-activating protein 75 4e-13
Hs22062818 [T] KOG2059 Ras GTPase-activating protein 72 5e-12
SPBC646.12c [T] KOG2128 Ras GTPase-activating protein family - I... 66 2e-10
YOL081w [V] KOG1826 Ras GTPase activating protein RasGAP/neurofi... 62 6e-09
YBR140c [V] KOG1826 Ras GTPase activating protein RasGAP/neurofi... 60 1e-08
>YKL092c [R] KOG3508 GTPase-activating protein
Length = 1104
Score = 734 bits (1895), Expect = 0.0
Identities = 427/1110 (38%), Positives = 648/1110 (57%), Gaps = 116/1110 (10%)
Query: 32 SSSKMGYLDEADFIERVRSSQGKFNGLLQWCSNLSLNEWRKNHLEINEKGSLTHAVNETD 91
+ S+ Y +F+ V+ + F G +QWC+NLSLN+W+ ++L+I G+LTH+++E
Sbjct: 8 AQSRTSYFKLNEFLSNVKHYKNTFKGEIQWCNNLSLNDWKTHYLQITSTGALTHSIDELT 67
Query: 92 VKSLQNTMDDFTDSIDLPSSSHPIINHLQNCELQLIH------QDNGDSTSPIIEVQTSS 145
S ++ PII HLQ C +++I +D + + II+V TS
Sbjct: 68 ADS---------------TNIQPIIKHLQQCRIEIIKDKHSSFKDINANCNFIIQVNTSG 112
Query: 146 --NSIYLKANSKXXXXXXXXXXVFWKSLKSNDVFNKTNVIQPIFHKPED---PISIILCQ 200
N +YL+ S ++W S+K+N +FNK V +P+ K + P S+++ +
Sbjct: 113 KDNKVYLRVKSWSDFKKLLTCLIWWSSMKTNGIFNKFQVSRPLEFKSKKMAKPESLLVYK 172
Query: 201 CHVFGPIPKNKHVQLSTYL---PKPSNGESDDYGWFAAMGVLKTDGILDLLIQSDGSLIY 257
+VFGPI KN + +T + P N + + GWF+AMGVLK++G+LDLL+QSDGSLIY
Sbjct: 173 LNVFGPIVKNIVLPPATNILESPDIINNDDNSVGWFSAMGVLKSNGMLDLLLQSDGSLIY 232
Query: 258 SIDVTKFLRSEIHIVDSSIFQSDKYLFMGILPQLRKQLQISSNESCFADNSRSSTKSRKL 317
S+++++ LRSEI I+DSS+ QS+ LF+G LP LR QL + + + ++T S +
Sbjct: 233 SLNISQLLRSEIRILDSSVLQSENSLFLGELPLLRSQLGLEKFR--IENIASAATNSSDI 290
Query: 318 SQYLYLRLPLRIDLEDWFVALNSFAMPDVLSLIGTDKSNELRISNRFKISILEADLRDLE 377
SQ + + PLRIDLED F+AL SFA + LS+ G+DKSN+++ISN FKISILEA+ + +
Sbjct: 291 SQEIIVEFPLRIDLEDCFIALQSFARSEYLSITGSDKSNDMKISNSFKISILEANFQSIN 350
Query: 378 IEKPR-----LYAEINLWDKAVARTAVVPSSTSPFWREEFNFNFSVRTNIIKIIIKCSVE 432
+ ++ +I W ART++V +S++PFWREEF FN +R + IK
Sbjct: 351 LNDKNNTPWSIFTDITAWGHTWARTSMVSNSSNPFWREEFQFNELLRLTNSYLEIKQLFH 410
Query: 433 DNSYSNKDSIIGEIQITQEMINDPNLNKETRLPVFSYTNKNFQIGTICIKTISSLNFVLQ 492
D + + +IG+I+ITQE+IND NKETRLP+ NKNFQIGTICIK S+LNF+L
Sbjct: 411 DLNNKKRLRLIGKIKITQEIINDTRYNKETRLPIMDVDNKNFQIGTICIKISSNLNFILP 470
Query: 493 PVNFTKFEQVLSKVSLPKICD--YMHDSKISADLKLEDISLVFLDIFQAINREDDWFQAL 550
NF K E++L +L + + Y S + D KL S++FLDIFQ+++R ++WF L
Sbjct: 471 STNFVKLEKLLMNANLSMVSNLIYKSSSSMENDNKLTQTSIIFLDIFQSLSRIEEWFHVL 530
Query: 551 IDREFQGLDKSITMSNSNHQSSNHIYNTLFRGNSILTKTMETYCYRVGQEYLDKCIGTVI 610
ID+E +D +++ N + S H++N+LFRGNSILTK++E Y +RVG EYL K + ++
Sbjct: 531 IDKELAKIDGTVSRINQKNLDSKHVFNSLFRGNSILTKSIEQYFFRVGNEYLSKALSAIL 590
Query: 611 RQLVEEDESYEIDPNRIKESELTEKEKIIETNFQKLLSLAERTWKLIFETSNDLPQGIKT 670
++++E ++S E+DP R+KE + +K KII N+++L S + WK ++ TSNDLP I+
Sbjct: 591 KEIIESNKSCELDPARVKEKDEVKKRKIIADNYKRLYSWVTKIWKRLYATSNDLPIEIRN 650
Query: 671 QLKCFRKKLEIIEPDEKISSKSLLNCISGFLFLRFFCPVILNPKIFNFVEHHPGENARRS 730
LK FR+KLEII D+ + + +LN ISG LFLRFFCPVILNPK+F +V + E ARR+
Sbjct: 651 VLKIFRQKLEIICIDDTL--QIILNGISGLLFLRFFCPVILNPKLFKYVSQNLNETARRN 708
Query: 731 LTLLAKVVMNLSTLTEFGSKEPWMKRMNSFIDDHKGQLLDYLDKITEKKLDFAPKKLKLS 790
LTL++KV++NLSTLT+F +KEPW+ +MN+FID LLDY+DK+T+KKLDF K L LS
Sbjct: 709 LTLISKVLLNLSTLTQFANKEPWLMKMNNFIDKRHNDLLDYIDKMTQKKLDFNSKILNLS 768
Query: 791 SSLTRPKLELSQDILKNLPANPFLIDKYLRETELINIFATSEESKSSKTVRSVSMEH--- 847
S+++RPKL + Q +L +LP P+L+DK LRETE +N+ + +K + M++
Sbjct: 769 STISRPKLAIEQTMLDDLPQIPYLLDKNLRETEFVNLIVNFSQEDMTKMEKYNHMDNGGK 828
Query: 848 ------------------MFKIVQDKPTEKSEFSIGGLEFEKMSENNTEVFG-----XXX 884
+ K D P E IG LEFEK++ENNTE+FG
Sbjct: 829 GELIEEEGLLSGSSLNLSVDKKDLDSPIEVKP-EIGELEFEKITENNTEIFGDDLMNLLK 887
Query: 885 XXXXXXXXXXXGNKAN----VHSLQSTPSNNGDLLNQLEQESVLLFNKIRQLVKVLDDYE 940
N AN +S+ + +LEQES LL+N+I + K L YE
Sbjct: 888 SDDVGSRSRDLDNGANSGIKFNSIIPKAEEEKHAMKELEQESCLLYNRINHIRKRLSGYE 947
Query: 941 YPNEIILGKSEYASFLANSLYYD---KEKKVYLDFQNLYALKDGYTKLFK---------- 987
+ + +Y+ L++ ++Y+ + K++ L N ++ +L K
Sbjct: 948 CASSTLFEDKKYSISLSHKIFYEEIKEGKEIVLKLLNKPTNENSSARLQKFFTKGVSSKS 1007
Query: 988 SNSTAESF--FVSSEKKDQ--------LIHHNSTDEAV-----------------NRTS- 1019
+N+ +S+ F++ + D+ +H S++ NR S
Sbjct: 1008 NNTVGDSYCKFLTIDVSDENPKSSNKTSVHGTSSENGAKDDYLTLPNSQGKGNLGNRFSP 1067
Query: 1020 -KFSMFGKSP--ADL-KQKSESKLARWFKK 1045
K S + P AD+ K+++ KL RWFKK
Sbjct: 1068 TKLSRIMRKPPNADVPKEQNSRKLTRWFKK 1097
>Hs4758808 [R] KOG3508 GTPase-activating protein
Length = 1139
Score = 141 bits (355), Expect = 6e-33
Identities = 117/436 (26%), Positives = 207/436 (46%), Gaps = 35/436 (8%)
Query: 343 MPDVLSLIGTDKSNELRISNRFKISILEADLRDLEIEKPRLYAEINLWDKAVARTAVVPS 402
M ++ + +K N R N ++ I+EA +DL +K + + E+ L D ART
Sbjct: 150 MENLRRTVQPNKDNCRRAENVLRLWIIEA--KDLAPKK-KYFCELCLDDTLFARTTSKTK 206
Query: 403 STSPFWREEFNFNFSVRTNIIKIIIKCSVEDNSYSNKDSIIGEIQITQEMINDPNLNKET 462
+ + FW E F F + I + I VE +K++ +G + I + E
Sbjct: 207 ADNIFWGEHFEFFSLPPLHSITVHIYKDVEKKKKKDKNNYVGLVNIPTASVTGRQF-VEK 265
Query: 463 RLPVFSYTNKNFQIG--TICIKTISSLNFVLQPVNFTKFEQVLSKVSLPKICDYMHDSKI 520
PV + T + G +I IK+ +L + +F + ++ + +C + + I
Sbjct: 266 WYPVSTPTPNKGKTGGPSIRIKSRFQTITILPMEQYKEFAEFVTS-NYTMLCSVL-EPVI 323
Query: 521 SADLKLEDISLVFLDIFQAINREDDWFQALIDREFQGLDKSITMSNSNHQSSNHIYNTLF 580
S K E+++ + I Q+ R D+ L+ MS + + + +F
Sbjct: 324 SVRNK-EELACALVHILQSTGRAKDFLTDLV------------MSEVDRCGEHDVL--IF 368
Query: 581 RGNSILTKTMETYCYRVGQEYLDKCIGTVIRQLVEEDESYEIDPNRIKESELTEKEKIIE 640
R N+I TK++E Y VGQ+YL +G I+ L E DE+ E+DP++ SEL + +
Sbjct: 369 RENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSKCSSSELIDHQS--- 425
Query: 641 TNFQKLLSLAERTWKLIFETSNDLPQGIKTQLKCFRKKLEIIEPDEKISSKSLLNCISGF 700
L E + I + P+ +K ++++ + + IS + IS
Sbjct: 426 ----NLKMCCELAFCKIINSYCVFPRELKEVFASWKQQC-LNRGKQDISER----LISAS 476
Query: 701 LFLRFFCPVILNPKIFNFVEHHPGENARRSLTLLAKVVMNLSTLTEFGSKEPWMKRMNSF 760
LFLRF CP I++P +FN ++ +P + R+LTL+AKV+ NL+ +FG+KE +M MN F
Sbjct: 477 LFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGNKEEYMAFMNDF 536
Query: 761 IDDHKGQLLDYLDKIT 776
++ G + +L +I+
Sbjct: 537 LEHEWGGMKRFLLEIS 552
>CE23475 [R] KOG3508 GTPase-activating protein
Length = 956
Score = 135 bits (341), Expect = 3e-31
Identities = 115/457 (25%), Positives = 205/457 (44%), Gaps = 60/457 (13%)
Query: 343 MPDVLSLIGTDKSNELRISNRFKISILEADLRDLEIEKPRLYAEINLWDKAVARTAVVPS 402
M ++ + + + R N I ILEA + L ++ + Y E+ L A+T+
Sbjct: 124 MENLRKTMNPRRDQQRRTENSMLIWILEA--KGLPAKR-KYYCEMTLDKTLYAKTSSKAR 180
Query: 403 STSPFWREEFNFNFSVRTNIIKIIIKCSVEDNSYSNKDSIIGEIQITQEMINDPNLNKET 462
+ + FW E NF F + I ++ + E +S KD++IG + I + ++ +
Sbjct: 181 TDNVFWGE--NFEFMMLPKIDEVCVSLFRESDSKKKKDTLIGYVTIGIDQLS-------S 231
Query: 463 RLPV---FSYTNKNFQIGT------------------ICIKTISSLNFVLQPVNFTKFEQ 501
R PV ++ + GT + IK +L + +
Sbjct: 232 RSPVERWYTVNTSHSDSGTSRIASALGGKSSSQESPSLRIKARWQSVHILPLRAYDNLLE 291
Query: 502 VLSKVSLPKICDYMHDSKISADLKLEDISLVFLDIFQAINREDDWFQALIDREFQGLDKS 561
L LP +C+ + D ED++ + + N ++ LI +E + LD
Sbjct: 292 TLCYNYLP-LCEQLEPVLNVRDK--EDLATSLVRVMYKHNLAKEFLCDLIMKEVEKLD-- 346
Query: 562 ITMSNSNHQSSNHIYNTLFRGNSILTKTMETYCYRVGQEYLDKCIGTVIRQLVEEDESYE 621
++H+ +FRGN++ TK ME++ V +YLD + I+ +++ ++S E
Sbjct: 347 ----------NDHL---MFRGNTLATKAMESFMKLVADDYLDSTLSDFIKTVLQCEDSCE 393
Query: 622 IDPNRIKESELTEKEKIIETNFQKLLSLAERTWKLIFETSNDLPQGIKTQLKCFRKKLEI 681
+DP ++ + EK N L+ E W I + LP+ ++ R +LE
Sbjct: 394 VDPQKLGNVSNSSLEK----NRALLMRYVEVAWTKILNNVHQLPKNLRDVFSALRCRLEA 449
Query: 682 IEPDEKISSKSLLNCISGFLFLRFFCPVILNPKIFNFVEHHPGENARRSLTLLAKVVMNL 741
+ + IS +FLRF CP IL+P +FN V +P R+LTL+AK + NL
Sbjct: 450 QNREALADT-----LISSSIFLRFLCPAILSPSLFNLVSEYPSPTNARNLTLIAKTLQNL 504
Query: 742 STLTEFGSKEPWMKRMNSFIDDHKGQLLDYLDKITEK 778
+ ++FG KEP M+ MN F+D ++ D+L +I+ +
Sbjct: 505 ANFSKFGGKEPHMEFMNEFVDREWHRMKDFLLRISSE 541
>CE23474 [R] KOG3508 GTPase-activating protein
Length = 1048
Score = 135 bits (341), Expect = 3e-31
Identities = 115/457 (25%), Positives = 205/457 (44%), Gaps = 60/457 (13%)
Query: 343 MPDVLSLIGTDKSNELRISNRFKISILEADLRDLEIEKPRLYAEINLWDKAVARTAVVPS 402
M ++ + + + R N I ILEA + L ++ + Y E+ L A+T+
Sbjct: 216 MENLRKTMNPRRDQQRRTENSMLIWILEA--KGLPAKR-KYYCEMTLDKTLYAKTSSKAR 272
Query: 403 STSPFWREEFNFNFSVRTNIIKIIIKCSVEDNSYSNKDSIIGEIQITQEMINDPNLNKET 462
+ + FW E NF F + I ++ + E +S KD++IG + I + ++ +
Sbjct: 273 TDNVFWGE--NFEFMMLPKIDEVCVSLFRESDSKKKKDTLIGYVTIGIDQLS-------S 323
Query: 463 RLPV---FSYTNKNFQIGT------------------ICIKTISSLNFVLQPVNFTKFEQ 501
R PV ++ + GT + IK +L + +
Sbjct: 324 RSPVERWYTVNTSHSDSGTSRIASALGGKSSSQESPSLRIKARWQSVHILPLRAYDNLLE 383
Query: 502 VLSKVSLPKICDYMHDSKISADLKLEDISLVFLDIFQAINREDDWFQALIDREFQGLDKS 561
L LP +C+ + D ED++ + + N ++ LI +E + LD
Sbjct: 384 TLCYNYLP-LCEQLEPVLNVRDK--EDLATSLVRVMYKHNLAKEFLCDLIMKEVEKLD-- 438
Query: 562 ITMSNSNHQSSNHIYNTLFRGNSILTKTMETYCYRVGQEYLDKCIGTVIRQLVEEDESYE 621
++H+ +FRGN++ TK ME++ V +YLD + I+ +++ ++S E
Sbjct: 439 ----------NDHL---MFRGNTLATKAMESFMKLVADDYLDSTLSDFIKTVLQCEDSCE 485
Query: 622 IDPNRIKESELTEKEKIIETNFQKLLSLAERTWKLIFETSNDLPQGIKTQLKCFRKKLEI 681
+DP ++ + EK N L+ E W I + LP+ ++ R +LE
Sbjct: 486 VDPQKLGNVSNSSLEK----NRALLMRYVEVAWTKILNNVHQLPKNLRDVFSALRCRLEA 541
Query: 682 IEPDEKISSKSLLNCISGFLFLRFFCPVILNPKIFNFVEHHPGENARRSLTLLAKVVMNL 741
+ + IS +FLRF CP IL+P +FN V +P R+LTL+AK + NL
Sbjct: 542 QNREALADT-----LISSSIFLRFLCPAILSPSLFNLVSEYPSPTNARNLTLIAKTLQNL 596
Query: 742 STLTEFGSKEPWMKRMNSFIDDHKGQLLDYLDKITEK 778
+ ++FG KEP M+ MN F+D ++ D+L +I+ +
Sbjct: 597 ANFSKFGGKEPHMEFMNEFVDREWHRMKDFLLRISSE 633
>CE23473 [R] KOG3508 GTPase-activating protein
Length = 1137
Score = 135 bits (341), Expect = 3e-31
Identities = 115/457 (25%), Positives = 205/457 (44%), Gaps = 60/457 (13%)
Query: 343 MPDVLSLIGTDKSNELRISNRFKISILEADLRDLEIEKPRLYAEINLWDKAVARTAVVPS 402
M ++ + + + R N I ILEA + L ++ + Y E+ L A+T+
Sbjct: 305 MENLRKTMNPRRDQQRRTENSMLIWILEA--KGLPAKR-KYYCEMTLDKTLYAKTSSKAR 361
Query: 403 STSPFWREEFNFNFSVRTNIIKIIIKCSVEDNSYSNKDSIIGEIQITQEMINDPNLNKET 462
+ + FW E NF F + I ++ + E +S KD++IG + I + ++ +
Sbjct: 362 TDNVFWGE--NFEFMMLPKIDEVCVSLFRESDSKKKKDTLIGYVTIGIDQLS-------S 412
Query: 463 RLPV---FSYTNKNFQIGT------------------ICIKTISSLNFVLQPVNFTKFEQ 501
R PV ++ + GT + IK +L + +
Sbjct: 413 RSPVERWYTVNTSHSDSGTSRIASALGGKSSSQESPSLRIKARWQSVHILPLRAYDNLLE 472
Query: 502 VLSKVSLPKICDYMHDSKISADLKLEDISLVFLDIFQAINREDDWFQALIDREFQGLDKS 561
L LP +C+ + D ED++ + + N ++ LI +E + LD
Sbjct: 473 TLCYNYLP-LCEQLEPVLNVRDK--EDLATSLVRVMYKHNLAKEFLCDLIMKEVEKLD-- 527
Query: 562 ITMSNSNHQSSNHIYNTLFRGNSILTKTMETYCYRVGQEYLDKCIGTVIRQLVEEDESYE 621
++H+ +FRGN++ TK ME++ V +YLD + I+ +++ ++S E
Sbjct: 528 ----------NDHL---MFRGNTLATKAMESFMKLVADDYLDSTLSDFIKTVLQCEDSCE 574
Query: 622 IDPNRIKESELTEKEKIIETNFQKLLSLAERTWKLIFETSNDLPQGIKTQLKCFRKKLEI 681
+DP ++ + EK N L+ E W I + LP+ ++ R +LE
Sbjct: 575 VDPQKLGNVSNSSLEK----NRALLMRYVEVAWTKILNNVHQLPKNLRDVFSALRCRLEA 630
Query: 682 IEPDEKISSKSLLNCISGFLFLRFFCPVILNPKIFNFVEHHPGENARRSLTLLAKVVMNL 741
+ + IS +FLRF CP IL+P +FN V +P R+LTL+AK + NL
Sbjct: 631 QNREALADT-----LISSSIFLRFLCPAILSPSLFNLVSEYPSPTNARNLTLIAKTLQNL 685
Query: 742 STLTEFGSKEPWMKRMNSFIDDHKGQLLDYLDKITEK 778
+ ++FG KEP M+ MN F+D ++ D+L +I+ +
Sbjct: 686 ANFSKFGGKEPHMEFMNEFVDREWHRMKDFLLRISSE 722
>CE23472 [R] KOG3508 GTPase-activating protein
Length = 1259
Score = 135 bits (341), Expect = 3e-31
Identities = 115/457 (25%), Positives = 205/457 (44%), Gaps = 60/457 (13%)
Query: 343 MPDVLSLIGTDKSNELRISNRFKISILEADLRDLEIEKPRLYAEINLWDKAVARTAVVPS 402
M ++ + + + R N I ILEA + L ++ + Y E+ L A+T+
Sbjct: 427 MENLRKTMNPRRDQQRRTENSMLIWILEA--KGLPAKR-KYYCEMTLDKTLYAKTSSKAR 483
Query: 403 STSPFWREEFNFNFSVRTNIIKIIIKCSVEDNSYSNKDSIIGEIQITQEMINDPNLNKET 462
+ + FW E NF F + I ++ + E +S KD++IG + I + ++ +
Sbjct: 484 TDNVFWGE--NFEFMMLPKIDEVCVSLFRESDSKKKKDTLIGYVTIGIDQLS-------S 534
Query: 463 RLPV---FSYTNKNFQIGT------------------ICIKTISSLNFVLQPVNFTKFEQ 501
R PV ++ + GT + IK +L + +
Sbjct: 535 RSPVERWYTVNTSHSDSGTSRIASALGGKSSSQESPSLRIKARWQSVHILPLRAYDNLLE 594
Query: 502 VLSKVSLPKICDYMHDSKISADLKLEDISLVFLDIFQAINREDDWFQALIDREFQGLDKS 561
L LP +C+ + D ED++ + + N ++ LI +E + LD
Sbjct: 595 TLCYNYLP-LCEQLEPVLNVRDK--EDLATSLVRVMYKHNLAKEFLCDLIMKEVEKLD-- 649
Query: 562 ITMSNSNHQSSNHIYNTLFRGNSILTKTMETYCYRVGQEYLDKCIGTVIRQLVEEDESYE 621
++H+ +FRGN++ TK ME++ V +YLD + I+ +++ ++S E
Sbjct: 650 ----------NDHL---MFRGNTLATKAMESFMKLVADDYLDSTLSDFIKTVLQCEDSCE 696
Query: 622 IDPNRIKESELTEKEKIIETNFQKLLSLAERTWKLIFETSNDLPQGIKTQLKCFRKKLEI 681
+DP ++ + EK N L+ E W I + LP+ ++ R +LE
Sbjct: 697 VDPQKLGNVSNSSLEK----NRALLMRYVEVAWTKILNNVHQLPKNLRDVFSALRCRLEA 752
Query: 682 IEPDEKISSKSLLNCISGFLFLRFFCPVILNPKIFNFVEHHPGENARRSLTLLAKVVMNL 741
+ + IS +FLRF CP IL+P +FN V +P R+LTL+AK + NL
Sbjct: 753 QNREALADT-----LISSSIFLRFLCPAILSPSLFNLVSEYPSPTNARNLTLIAKTLQNL 807
Query: 742 STLTEFGSKEPWMKRMNSFIDDHKGQLLDYLDKITEK 778
+ ++FG KEP M+ MN F+D ++ D+L +I+ +
Sbjct: 808 ANFSKFGGKEPHMEFMNEFVDREWHRMKDFLLRISSE 844
>CE23471 [R] KOG3508 GTPase-activating protein
Length = 1170
Score = 135 bits (341), Expect = 3e-31
Identities = 115/457 (25%), Positives = 205/457 (44%), Gaps = 60/457 (13%)
Query: 343 MPDVLSLIGTDKSNELRISNRFKISILEADLRDLEIEKPRLYAEINLWDKAVARTAVVPS 402
M ++ + + + R N I ILEA + L ++ + Y E+ L A+T+
Sbjct: 338 MENLRKTMNPRRDQQRRTENSMLIWILEA--KGLPAKR-KYYCEMTLDKTLYAKTSSKAR 394
Query: 403 STSPFWREEFNFNFSVRTNIIKIIIKCSVEDNSYSNKDSIIGEIQITQEMINDPNLNKET 462
+ + FW E NF F + I ++ + E +S KD++IG + I + ++ +
Sbjct: 395 TDNVFWGE--NFEFMMLPKIDEVCVSLFRESDSKKKKDTLIGYVTIGIDQLS-------S 445
Query: 463 RLPV---FSYTNKNFQIGT------------------ICIKTISSLNFVLQPVNFTKFEQ 501
R PV ++ + GT + IK +L + +
Sbjct: 446 RSPVERWYTVNTSHSDSGTSRIASALGGKSSSQESPSLRIKARWQSVHILPLRAYDNLLE 505
Query: 502 VLSKVSLPKICDYMHDSKISADLKLEDISLVFLDIFQAINREDDWFQALIDREFQGLDKS 561
L LP +C+ + D ED++ + + N ++ LI +E + LD
Sbjct: 506 TLCYNYLP-LCEQLEPVLNVRDK--EDLATSLVRVMYKHNLAKEFLCDLIMKEVEKLD-- 560
Query: 562 ITMSNSNHQSSNHIYNTLFRGNSILTKTMETYCYRVGQEYLDKCIGTVIRQLVEEDESYE 621
++H+ +FRGN++ TK ME++ V +YLD + I+ +++ ++S E
Sbjct: 561 ----------NDHL---MFRGNTLATKAMESFMKLVADDYLDSTLSDFIKTVLQCEDSCE 607
Query: 622 IDPNRIKESELTEKEKIIETNFQKLLSLAERTWKLIFETSNDLPQGIKTQLKCFRKKLEI 681
+DP ++ + EK N L+ E W I + LP+ ++ R +LE
Sbjct: 608 VDPQKLGNVSNSSLEK----NRALLMRYVEVAWTKILNNVHQLPKNLRDVFSALRCRLEA 663
Query: 682 IEPDEKISSKSLLNCISGFLFLRFFCPVILNPKIFNFVEHHPGENARRSLTLLAKVVMNL 741
+ + IS +FLRF CP IL+P +FN V +P R+LTL+AK + NL
Sbjct: 664 QNREALADT-----LISSSIFLRFLCPAILSPSLFNLVSEYPSPTNARNLTLIAKTLQNL 718
Query: 742 STLTEFGSKEPWMKRMNSFIDDHKGQLLDYLDKITEK 778
+ ++FG KEP M+ MN F+D ++ D+L +I+ +
Sbjct: 719 ANFSKFGGKEPHMEFMNEFVDREWHRMKDFLLRISSE 755
>CE23470 [R] KOG3508 GTPase-activating protein
Length = 1207
Score = 135 bits (341), Expect = 3e-31
Identities = 115/457 (25%), Positives = 205/457 (44%), Gaps = 60/457 (13%)
Query: 343 MPDVLSLIGTDKSNELRISNRFKISILEADLRDLEIEKPRLYAEINLWDKAVARTAVVPS 402
M ++ + + + R N I ILEA + L ++ + Y E+ L A+T+
Sbjct: 375 MENLRKTMNPRRDQQRRTENSMLIWILEA--KGLPAKR-KYYCEMTLDKTLYAKTSSKAR 431
Query: 403 STSPFWREEFNFNFSVRTNIIKIIIKCSVEDNSYSNKDSIIGEIQITQEMINDPNLNKET 462
+ + FW E NF F + I ++ + E +S KD++IG + I + ++ +
Sbjct: 432 TDNVFWGE--NFEFMMLPKIDEVCVSLFRESDSKKKKDTLIGYVTIGIDQLS-------S 482
Query: 463 RLPV---FSYTNKNFQIGT------------------ICIKTISSLNFVLQPVNFTKFEQ 501
R PV ++ + GT + IK +L + +
Sbjct: 483 RSPVERWYTVNTSHSDSGTSRIASALGGKSSSQESPSLRIKARWQSVHILPLRAYDNLLE 542
Query: 502 VLSKVSLPKICDYMHDSKISADLKLEDISLVFLDIFQAINREDDWFQALIDREFQGLDKS 561
L LP +C+ + D ED++ + + N ++ LI +E + LD
Sbjct: 543 TLCYNYLP-LCEQLEPVLNVRDK--EDLATSLVRVMYKHNLAKEFLCDLIMKEVEKLD-- 597
Query: 562 ITMSNSNHQSSNHIYNTLFRGNSILTKTMETYCYRVGQEYLDKCIGTVIRQLVEEDESYE 621
++H+ +FRGN++ TK ME++ V +YLD + I+ +++ ++S E
Sbjct: 598 ----------NDHL---MFRGNTLATKAMESFMKLVADDYLDSTLSDFIKTVLQCEDSCE 644
Query: 622 IDPNRIKESELTEKEKIIETNFQKLLSLAERTWKLIFETSNDLPQGIKTQLKCFRKKLEI 681
+DP ++ + EK N L+ E W I + LP+ ++ R +LE
Sbjct: 645 VDPQKLGNVSNSSLEK----NRALLMRYVEVAWTKILNNVHQLPKNLRDVFSALRCRLEA 700
Query: 682 IEPDEKISSKSLLNCISGFLFLRFFCPVILNPKIFNFVEHHPGENARRSLTLLAKVVMNL 741
+ + IS +FLRF CP IL+P +FN V +P R+LTL+AK + NL
Sbjct: 701 QNREALADT-----LISSSIFLRFLCPAILSPSLFNLVSEYPSPTNARNLTLIAKTLQNL 755
Query: 742 STLTEFGSKEPWMKRMNSFIDDHKGQLLDYLDKITEK 778
+ ++FG KEP M+ MN F+D ++ D+L +I+ +
Sbjct: 756 ANFSKFGGKEPHMEFMNEFVDREWHRMKDFLLRISSE 792
>Hs4506431 [R] KOG3508 GTPase-activating protein
Length = 1047
Score = 127 bits (319), Expect = 9e-29
Identities = 99/392 (25%), Positives = 181/392 (45%), Gaps = 32/392 (8%)
Query: 384 YAEINLWDKAVARTAVVPSSTSPFWREEFNFNFSVRTNIIKIIIKCSVEDNSYSNKDSII 443
Y I L VA+T +P W EEF F+ + +I + I S + + D +
Sbjct: 615 YCNIYLNSVQVAKTHA-REGQNPVWSEEFVFD-DLPPDINRFEITLSNKTKKSKDPDILF 672
Query: 444 GEIQITQEMINDPNLNKETRLPVFSYTNKNFQIGTICIKTISSLNFVLQPVNFTKFEQVL 503
Q+++ + + E L K + G++ ++ S+ ++ +++F++++
Sbjct: 673 MRCQLSR--LQKGHATDEWFLLSSHIPLKGIEPGSLRVRARYSMEKIMPEEEYSEFKELI 730
Query: 504 SKVSLPKICDYMHDSKISADLKLEDISLVFLDIFQAINREDDWFQALIDREFQGLDKSIT 563
+ L + H L ++ + L IF E L DRE D++
Sbjct: 731 LQKELHVVYALSHVCGQDRTL----LASILLRIFLHEKLESLLLCTLNDREISMEDEA-- 784
Query: 564 MSNSNHQSSNHIYNTLFRGNSILTKTMETYCYRVGQEYLDKCIGTVIRQLVEEDESYEID 623
TLFR ++ + ME Y +++ + I +++E +S E+
Sbjct: 785 -------------TTLFRATTLASTLMEQYMKATATQFVHHALKDSILKIMESKQSCELS 831
Query: 624 PNRIKESELTEKEKIIETNFQKLLSLAERTWKLIFETSNDLPQGIKTQLKCFRKKLEIIE 683
P+++ EK + + TN LL++ + IF S LP ++ C +K ++
Sbjct: 832 PSKL------EKNEDVNTNLTHLLNILSELVEKIFMASEILPPTLRYIYGCLQKSVQHKW 885
Query: 684 PDEKISSKSLLNCISGFLFLRFFCPVILNPKIFNFVEHHPGENARRSLTLLAKVVMNLST 743
P ++ +SGF+FLR CP ILNP++FN + P A R+L L+AK V NL+
Sbjct: 886 PT---NTTMRTRVVSGFVFLRLICPAILNPRMFNIISDSPSPIAARTLILVAKSVQNLAN 942
Query: 744 LTEFGSKEPWMKRMNSFIDDHKGQLLDYLDKI 775
L EFG+KEP+M+ +N FI +K +++ +LD++
Sbjct: 943 LVEFGAKEPYMEGVNPFIKSNKHRMIMFLDEL 974
>Hs12545406 [R] KOG3508 GTPase-activating protein
Length = 870
Score = 127 bits (319), Expect = 9e-29
Identities = 99/392 (25%), Positives = 181/392 (45%), Gaps = 32/392 (8%)
Query: 384 YAEINLWDKAVARTAVVPSSTSPFWREEFNFNFSVRTNIIKIIIKCSVEDNSYSNKDSII 443
Y I L VA+T +P W EEF F+ + +I + I S + + D +
Sbjct: 438 YCNIYLNSVQVAKTHA-REGQNPVWSEEFVFD-DLPPDINRFEITLSNKTKKSKDPDILF 495
Query: 444 GEIQITQEMINDPNLNKETRLPVFSYTNKNFQIGTICIKTISSLNFVLQPVNFTKFEQVL 503
Q+++ + + E L K + G++ ++ S+ ++ +++F++++
Sbjct: 496 MRCQLSR--LQKGHATDEWFLLSSHIPLKGIEPGSLRVRARYSMEKIMPEEEYSEFKELI 553
Query: 504 SKVSLPKICDYMHDSKISADLKLEDISLVFLDIFQAINREDDWFQALIDREFQGLDKSIT 563
+ L + H L ++ + L IF E L DRE D++
Sbjct: 554 LQKELHVVYALSHVCGQDRTL----LASILLRIFLHEKLESLLLCTLNDREISMEDEA-- 607
Query: 564 MSNSNHQSSNHIYNTLFRGNSILTKTMETYCYRVGQEYLDKCIGTVIRQLVEEDESYEID 623
TLFR ++ + ME Y +++ + I +++E +S E+
Sbjct: 608 -------------TTLFRATTLASTLMEQYMKATATQFVHHALKDSILKIMESKQSCELS 654
Query: 624 PNRIKESELTEKEKIIETNFQKLLSLAERTWKLIFETSNDLPQGIKTQLKCFRKKLEIIE 683
P+++ EK + + TN LL++ + IF S LP ++ C +K ++
Sbjct: 655 PSKL------EKNEDVNTNLTHLLNILSELVEKIFMASEILPPTLRYIYGCLQKSVQHKW 708
Query: 684 PDEKISSKSLLNCISGFLFLRFFCPVILNPKIFNFVEHHPGENARRSLTLLAKVVMNLST 743
P ++ +SGF+FLR CP ILNP++FN + P A R+L L+AK V NL+
Sbjct: 709 PT---NTTMRTRVVSGFVFLRLICPAILNPRMFNIISDSPSPIAARTLILVAKSVQNLAN 765
Query: 744 LTEFGSKEPWMKRMNSFIDDHKGQLLDYLDKI 775
L EFG+KEP+M+ +N FI +K +++ +LD++
Sbjct: 766 LVEFGAKEPYMEGVNPFIKSNKHRMIMFLDEL 797
>CE28277 [R] KOG3508 GTPase-activating protein
Length = 787
Score = 125 bits (313), Expect = 5e-28
Identities = 99/399 (24%), Positives = 181/399 (44%), Gaps = 36/399 (9%)
Query: 386 EINLWDKAVARTAVVPSSTSPFWR------EEFNFNFSVRTNIIKIIIKCSVEDNSYSNK 439
E + WD + ++++P S + + EEF+ + N++K I +Y
Sbjct: 4 EYDPWDPSFHNSSMIPYSLASIYPSIENLPEEFSNENNKIKNVLKNFIWSFKLKKNYVRV 63
Query: 440 DSIIGEIQITQEMINDPNLNKETRLPVFSYTNKNFQIGTICIKTISSLNFVLQPVNFTKF 499
S+ GE + + + L S + ++ ++ IK +L +
Sbjct: 64 SSLFGEYTVNTSHSDSGTSRIASALGGKSSSQES---PSLRIKARWQSVHILPLRAYDNL 120
Query: 500 EQVLSKVSLPKICDYMHDSKISADLKLEDISLVFLDIFQAINREDDWFQALIDREFQGLD 559
+ L LP +C+ + D ED++ + + N ++ LI +E + LD
Sbjct: 121 LETLCYNYLP-LCEQLEPVLNVRDK--EDLATSLVRVMYKHNLAKEFLCDLIMKEVEKLD 177
Query: 560 KSITMSNSNHQSSNHIYNTLFRGNSILTKTMETYCYRVGQEYLDKCIGTVIRQLVEEDES 619
++H+ +FRGN++ TK ME++ V +YLD + I+ +++ ++S
Sbjct: 178 ------------NDHL---MFRGNTLATKAMESFMKLVADDYLDSTLSDFIKTVLQCEDS 222
Query: 620 YEIDPNRIKESELTEKEKIIETNFQKLLSLAERTWKLIFETSNDLPQGIKTQLKCFRKKL 679
E+DP ++ + EK N L+ E W I + LP+ ++ R +L
Sbjct: 223 CEVDPQKLGNVSNSSLEK----NRALLMRYVEVAWTKILNNVHQLPKNLRDVFSALRCRL 278
Query: 680 EIIEPDEKISSKSLLNCISGFLFLRFFCPVILNPKIFNFVEHHPGENARRSLTLLAKVVM 739
E + + IS +FLRF CP IL+P +FN V +P R+LTL+AK +
Sbjct: 279 EAQNREALADT-----LISSSIFLRFLCPAILSPSLFNLVSEYPSPTNARNLTLIAKTLQ 333
Query: 740 NLSTLTEFGSKEPWMKRMNSFIDDHKGQLLDYLDKITEK 778
NL+ ++FG KEP M+ MN F+D ++ D+L +I+ +
Sbjct: 334 NLANFSKFGGKEPHMEFMNEFVDREWHRMKDFLLRISSE 372
>Hs20070109 [R] KOG3508 GTPase-activating protein
Length = 967
Score = 124 bits (312), Expect = 6e-28
Identities = 125/490 (25%), Positives = 218/490 (43%), Gaps = 54/490 (11%)
Query: 343 MPDVLSLIGTDKSNELRISNRFKISILEADLRDLEIEKPRLYAEINLWDKAVARTAVVPS 402
M ++ + +K N R+ + K+ ++EA +DL +K L E+ L D ART
Sbjct: 1 MENLRRAVHPNKDNSRRVEHILKLWVIEA--KDLPAKKKYL-CELCLDDVLYARTTGKLK 57
Query: 403 STSPFWREEFNFNFSVRTNIIKIIIKCSVEDNSYSNKDSIIGEIQITQEMINDPNLNKET 462
+ + FW E F F+ + + + + ++S +G + + + E
Sbjct: 58 TDNVFWGEHFEFHNLPPLRTVTVHLYRETDKKKKKERNSYLGLVSLPAASVAGRQF-VEK 116
Query: 463 RLPVFSYTNKNFQIG--TICIKTISSLNFVLQPVNFTKFEQVLSKVSLPKICDYMHDSKI 520
PV + K + I IK +L + +F + ++ L +C + + +
Sbjct: 117 WYPVVTPNPKGGKGPGPMIRIKARYQTITILPMEMYKEFAEHITNHYLG-LCAAL-EPIL 174
Query: 521 SADLKLEDISLVFLDIFQAINREDDWFQALIDREFQGLDKSITMSNSNHQSSNHIYNTLF 580
SA K E+++ + I Q+ + D+ L+ MS + N + +F
Sbjct: 175 SAKTK-EEMASALVHILQSTGKVKDFLTDLM------------MSEVDRCGDNE--HLIF 219
Query: 581 RGNSILTKTMETYCYRVGQEYLDKCIGTVIRQLVEEDESYEIDPNRIKESELTEKEKIIE 640
R N++ TK +E Y VGQ+YL +G I+ L E DE+ E+DP++ ++L E +
Sbjct: 220 RENTLATKAIEEYLKLVGQKYLQDALGEFIKALYESDENCEVDPSKCSAADLPEHQG--- 276
Query: 641 TNFQKLLSLAERTWKLIFETSND---LPQGIKTQLKCFRKKLEII-EPDEKISSKSLLNC 696
N + LA +T N P+ +K +R++ PD IS +
Sbjct: 277 -NLKMCCELA------FCKTINSYCVFPRELKEVFASWRQECSSRGRPD--ISER----L 323
Query: 697 ISGFLFLRFFCPVILNPKIFNFVEHHPGENARRSLTLLAKVVMNLSTLTEFGSKEPWMKR 756
IS LFLRF CP I++P +FN ++ +P + R+LTL+AKV NL+ +FGSKE +M
Sbjct: 324 ISASLFLRFLCPAIMSPSLFNLLQEYPDDRTARTLTLIAKVTQNLANFAKFGSKEEYMSF 383
Query: 757 MNSFIDDHKGQLLDYLDKIT-----------EKKLDFAPKKLKLSSSLTRPKLELSQDIL 805
MN F++ + +L +I+ E +D + L S L +L Q I+
Sbjct: 384 MNQFLEHEWTNMQRFLLEISNPETLSNTAGFEGYIDLGRELSSLHSLLWEAVSQLEQSIV 443
Query: 806 KNLPANPFLI 815
L P ++
Sbjct: 444 SKLGPLPRIL 453
>7293383 [R] KOG3508 GTPase-activating protein
Length = 1436
Score = 123 bits (308), Expect = 2e-27
Identities = 107/455 (23%), Positives = 191/455 (41%), Gaps = 49/455 (10%)
Query: 350 IGTDKSNELRISNRFKISILEADLRDLEIEKPRLYAEINLWDKAVARTAVVPSSTSPFWR 409
I + + R N K+ + EA ++L +K R + E+ L RT+V + FW
Sbjct: 146 IAPNAEHTRRTDNSLKMWVYEA--KNLPPKK-RYFCELQLDKTLYGRTSVKLQTDLLFWG 202
Query: 410 EEFNFNFSVRTNIIKIIIKCSVEDNSYSNKDSIIGEIQITQEMINDPNLNKETRLPVFSY 469
E F+F N+I + + V+ +K +G ++I + L E P+ S
Sbjct: 203 EHFDFPDIPEINVITVNVFREVDKKKKRDKYQFVGSVKIPVHDVTS-RLPCEQWYPILSD 261
Query: 470 ----------------TNKNFQIGTICIKTISSLNFVLQPVNFTKFEQVLSKVSLPKICD 513
+ Q+ T+ IK +L P+N K + ++C+
Sbjct: 262 KAGDSLGRTSGGGGSGSKDKEQLPTLRIKCRFQSTDIL-PINVYGNFLTYLKENYKRVCE 320
Query: 514 YMHDSKISADLKLEDISLVFLDIFQAINREDDWFQALIDREFQGL-DKSITMSNSNHQSS 572
+ + I K EDI + + A + ++ + + D+ +T
Sbjct: 321 TL-EPVIGVKAK-EDIGQALVLLMHAQGLAGAFLTDVVALDLLRVGDQRLT--------- 369
Query: 573 NHIYNTLFRGNSILTKTMETYCYRVGQEYLDKCIGTVIRQLVEEDESYEIDPNRIKESEL 632
FRGNS+ TK+ME + G++YL + I +L++ + E+DP + S
Sbjct: 370 -------FRGNSLATKSMEAFLKLTGEQYLQDTLSAPINELIQSERDCEVDPTKTSGSSA 422
Query: 633 TEKEKIIETNFQKLLSLAERTWKLIFETSNDLPQGIKTQLKCFRKKLEIIEPDEKISSKS 692
++ L W+ IFE+ P ++ FR++L+ + +
Sbjct: 423 GS----LQRQQAALRGAVRGAWQCIFESHKHFPAQLRNCFATFRERLQQLGRQDMAD--- 475
Query: 693 LLNCISGFLFLRFFCPVILNPKIFNFVEHHPGENARRSLTLLAKVVMNLSTLTEFGSKEP 752
N IS +FLRF CP IL+P +FN P A R+LTL+AK + L+ T F KE
Sbjct: 476 --NLISASIFLRFLCPAILSPSLFNITSELPSARATRNLTLVAKTLQTLANFTRFQGKEN 533
Query: 753 WMKRMNSFIDDHKGQLLDYLDKITEKKLDFAPKKL 787
+M+ +N F++ ++ +L+ I+ + AP +
Sbjct: 534 FMEFLNDFLEQEAARMQQFLEIISTRPEHPAPDSI 568
>7293174 [R] KOG3508 GTPase-activating protein
Length = 925
Score = 119 bits (297), Expect = 3e-26
Identities = 108/463 (23%), Positives = 206/463 (44%), Gaps = 43/463 (9%)
Query: 317 LSQYLYLRLPLRIDLEDWFVALNSFAMPDVLSLIGTDKSNELRISNRFKISILEADLRDL 376
L+ YL P + +W +L A D K + LR + +LEA
Sbjct: 430 LATVTYLCAPSQESYVEWINSLK--AQCDSQLSRAQKKVSRLRELRCLNLHVLEAHRLPF 487
Query: 377 EIEKPRLYAEINLWDKAVARTAVVPSSTSPFWREEFNFNFSVRTNIIKIIIKCSVEDNSY 436
++ P Y I+L V +T V + P W EEF + V +++ + I ++
Sbjct: 488 KLV-PHPYCSISLNQVKVGKTRV-KIAPEPVWEEEFVLD-DVPPDVVSLTI--TLISRGK 542
Query: 437 SNKDSIIGEIQITQEMINDPNLNKETRLPVFSYTNKNFQIGTICIKTISSLNFVLQPVNF 496
KDS + E+ I + + E + T + G++ ++ + ++ +
Sbjct: 543 RGKDSEVAELTIDLSSLKNGQ-ETEGWYQLTGMTPMG-EWGSLRLRMRYLDDLIMPCEEY 600
Query: 497 TKFEQVLSKVSL---PKICDYMHDSKISADLKLEDISLVFLDIFQAINREDDWFQALIDR 553
+ +Q+L + L + + H+ ++ ++ L +F+ RE + + L
Sbjct: 601 SPLQQLLLESELYAVKALAELCHNDRVP-------LATALLRVFRQEKRETELIRMLCQA 653
Query: 554 EFQGLDKSITMSNSNHQSSNHIYNTLFRGNSILTKTMETYCYRVGQEYLDKCIGTVIRQL 613
E +T N TLFRG S+ T M+ Y +L + ++++
Sbjct: 654 E-------VTRENET--------TTLFRGASLATTLMDLYMRTECSGFLQSAVSETVQRI 698
Query: 614 VEEDESYEIDPNRIKESELTEKEKIIETNFQKLLSLAERTWKLIFETSNDLPQGIKTQLK 673
+E +S E++P ++ ++ TN + LL + + + IF + + P+ ++
Sbjct: 699 LESKQSAELNPTKMDVNDDAC------TNAEFLLQILDLVTQSIFTSPDACPRNVRFICS 752
Query: 674 CFRKKLEIIEPDEKISSKSLLNCISGFLFLRFFCPVILNPKIFNFVEHHPGENARRSLTL 733
C +K + P E++ + +SGF+FLR CP +LNP+ F V P A RSL +
Sbjct: 753 CLQKAVMAKWPTERLVRTRV---VSGFIFLRLLCPALLNPRQFGLVSETPPMAATRSLVM 809
Query: 734 LAKVVMNLSTLTEFGSKEPWMKRMNSFIDDHKGQLLDYLDKIT 776
+AK + NL+ L EFG KE +M+ +N FI +K +++ +LD+++
Sbjct: 810 VAKCLQNLANLIEFGGKEQYMEVVNPFILKNKERMIVFLDQLS 852
>Hs20546119 [R] KOG3508 GTPase-activating protein
Length = 478
Score = 115 bits (288), Expect = 4e-25
Identities = 70/215 (32%), Positives = 111/215 (51%), Gaps = 12/215 (5%)
Query: 579 LFRGNSILTKTMETYCYRVGQEYLDKCIGTVIRQLVEEDESYEIDPNRIKESELTEKEKI 638
LFR N++ TK ++ Y V Q+YL + +G V+R+L E E+DP++ SEL E +
Sbjct: 33 LFRENTLATKAIDEYMKLVAQDYLQETLGQVVRRLCASTEDCEVDPSKCPASELPEHQA- 91
Query: 639 IETNFQKLLSLAERTWKLIFETSNDLPQGIKTQLKCFRKKLEIIEPDEKISSKSLLNCIS 698
+L + E ++ I + + P + +R+ + E ++ L+ C S
Sbjct: 92 ------RLRNSCEEVFETIIHSYDWFPAELGIVFSSWREACK--ERGSEVLGPRLV-CAS 142
Query: 699 GFLFLRFFCPVILNPKIFNFVEHHPGENARRSLTLLAKVVMNLSTLTEFGSKEPWMKRMN 758
LFLR CP IL P +F HP R+LTL+AKV+ NL+ FG KE +M MN
Sbjct: 143 --LFLRLLCPAILAPSLFGLAPDHPAPGPARTLTLIAKVIQNLANRAPFGEKEAYMGFMN 200
Query: 759 SFIDDHKGQLLDYLDKITEKKLDFAPKKLKLSSSL 793
SF+++H + +LD++ +D AP + S L
Sbjct: 201 SFLEEHGPAMQCFLDQVAMVDVDAAPSGYQGSGDL 235
>Hs22060041 [R] KOG3508 GTPase-activating protein
Length = 877
Score = 106 bits (265), Expect = 2e-22
Identities = 81/274 (29%), Positives = 130/274 (46%), Gaps = 25/274 (9%)
Query: 579 LFRGNSILTKTMETYCYRVGQEYLDKCIGTVIRQLVEEDESYEIDPNRIKESELTEKEKI 638
+FR N++ TK +E Y +GQ+YL IG IR L E +E+ E+DP + S L E +
Sbjct: 75 IFRENTLATKAIEEYMRLIGQKYLKDAIGEFIRALYESEENCEVDPIKCTASSLAEHQA- 133
Query: 639 IETNFQKLLSLAERTWKLIFETSNDLPQGIKTQLKCFRKKLEIIEPDEKISSKSLLNCIS 698
L E + + P+ +K +R L E + + L IS
Sbjct: 134 ------NLRMCCELALCKVVNSHCVFPRELKEVFASWR--LRCAERGREDIADRL---IS 182
Query: 699 GFLFLRFFCPVILNPKIFNFVEHHPGENARRSLTLLAKVVMNLSTLTEFGSKEPWMKRMN 758
LFLRF CP I++P +F ++ +P E R+LTL+AKV+ NL+ ++F SKE ++ MN
Sbjct: 183 ASLFLRFLCPAIMSPSLFGLMQEYPDEQTSRTLTLIAKVIQNLANFSKFTSKEDFLGFMN 242
Query: 759 SFIDDHKGQLLDYLDKIT-----------EKKLDFAPKKLKLSSSLTRPKLELSQDILKN 807
F++ G + +L +I+ E +D + L + L +LS++ L
Sbjct: 243 EFLELEWGSMQQFLYEISNLDTLTNSSSFEGYIDLGRELSTLHALLWEVLPQLSKEALLK 302
Query: 808 LPANPFLIDKYLRETELINIFATSEESKSSKTVR 841
L P L++ T L N + S+ S+ R
Sbjct: 303 LGPLPRLLNDI--STALRNPNIQRQPSRQSERPR 334
>Hs4759026 [T] KOG2059 Ras GTPase-activating protein
Length = 804
Score = 100 bits (249), Expect = 1e-20
Identities = 68/211 (32%), Positives = 104/211 (49%), Gaps = 11/211 (5%)
Query: 577 NTLFRGNSILTKTMETYCYRVGQEYLDKCIGTVIRQLVEEDESYEIDP--------NRIK 628
NTLFR NS+ +K+ME + VG YL + + VI ++ EE + E+DP RI
Sbjct: 338 NTLFRSNSLASKSMEQFMKLVGMPYLHEVLKPVISRVFEEKKYMELDPCKMDLGRTRRIS 397
Query: 629 ESELTEKEKIIETNFQKLLSLAERTWKLIFETSNDLPQGIKTQLKCFRKKLEIIEPDEKI 688
+E++ ET+ L I + P ++ K +++E P +
Sbjct: 398 FKGALSEEQMRETSLGLLTGYLGPIVDAIVGSVGRCPPAMRLAFKQLHRRVEERFPQAEH 457
Query: 689 SSKSLLNCISGFLFLRFFCPVILNPKIFNFVEHHPGENARRSLTLLAKVVMNLSTL-TEF 747
L ISGFLFLRFF P IL PK+F+ + H RSL LLAK V ++ L +
Sbjct: 458 QDVKYL-AISGFLFLRFFAPAILTPKLFDLRDQHADPQTSRSLLLLAKAVQSIGNLGQQL 516
Query: 748 G-SKEPWMKRMNSFIDDHKGQLLDYLDKITE 777
G KE WM ++ F+ ++ D+LD++ +
Sbjct: 517 GQGKELWMAPLHPFLLQCVSRVRDFLDRLVD 547
>Hs5901958 [T] KOG2059 Ras GTPase-activating protein
Length = 826
Score = 94.0 bits (232), Expect = 1e-18
Identities = 58/212 (27%), Positives = 107/212 (50%), Gaps = 13/212 (6%)
Query: 577 NTLFRGNSILTKTMETYCYRVGQEYLDKCIGTVIRQLVEEDESYEIDPNRIKESEL---- 632
NTLFR NS+ +K+ME++ G +YL +G +I ++ EE + E+DP++++ ++
Sbjct: 362 NTLFRSNSLASKSMESFLKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSG 421
Query: 633 -----TEKEKIIETNFQKLLSLAERTWKLIFETSNDLPQGIKTQLKCFRKKLEIIEPDEK 687
TE E ++E + Q L + + + P ++ + +++ P +
Sbjct: 422 LHRPQTEAE-VLEQSAQTLRAHLGALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQ 480
Query: 688 ISSKSLLNCISGFLFLRFFCPVILNPKIFNFVEHHPGENARRSLTLLAKVVMNLSTLTEF 747
+ + ++ FL LRFF P I++PK+F+ E H R+L LLAK V N+ +
Sbjct: 481 HENVPFI-AVTSFLCLRFFSPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNVGNMDTP 539
Query: 748 GS--KEPWMKRMNSFIDDHKGQLLDYLDKITE 777
S KE WM+ + + QL D++ K+ +
Sbjct: 540 ASRAKEAWMEPLQPTVRQGVAQLKDFITKLVD 571
>Hs12545410 [T] KOG2059 Ras GTPase-activating protein
Length = 834
Score = 89.4 bits (220), Expect = 3e-17
Identities = 61/208 (29%), Positives = 101/208 (48%), Gaps = 20/208 (9%)
Query: 577 NTLFRGNSILTKTMETYCYRVGQEYLDKCIGTVIRQLVEEDESYEIDPNRIKESELTEKE 636
NT+FRGNS+ +K ++ G YL + I ++ + + EIDP ++K+ E
Sbjct: 367 NTIFRGNSLASKCIDETMKLAGMHYLHVTLKPAIEEICQSHKPCEIDPVKLKDGEN---- 422
Query: 637 KIIETNFQKLLSLAERTWKLIFETSNDLPQ---GIKTQLKCFRKKLEIIEPDEKISSKSL 693
+E N + L +R + I E+ P I L+ K +PD + ++
Sbjct: 423 --LENNMENLRQYVDRVFHAITESGVSCPTVMCDIFFSLREAAAKRFQDDPDVRYTA--- 477
Query: 694 LNCISGFLFLRFFCPVILNPKIFNFVEHHPGENARRSLTLLAKVVMNLSTLTEFGS---K 750
+S F+FLRFF P IL+P +F HH R+LTL++K V L +L++ S K
Sbjct: 478 ---VSSFIFLRFFAPAILSPNLFQLTPHHTDPQTSRTLTLISKTVQTLGSLSKSKSASFK 534
Query: 751 EPWMKRMNSFIDDHK--GQLLDYLDKIT 776
E +M F ++ K + ++LD I+
Sbjct: 535 ESYMATFYEFFNEQKYADAVKNFLDLIS 562
>7301417 [V] KOG1826 Ras GTPase activating protein RasGAP/neurofibromin
Length = 2802
Score = 89.4 bits (220), Expect = 3e-17
Identities = 56/190 (29%), Positives = 103/190 (53%), Gaps = 14/190 (7%)
Query: 578 TLFRGNSILTKTMETYCYRV-GQEYLDKCIGTVIRQLVEEDES--YEIDPNRIKESELTE 634
TLFRGNS+ +K M +C+++ G YL + +IR L++E+E +E+DP R+ +E E
Sbjct: 1317 TLFRGNSLGSKIM-AFCFKIYGASYLQMLLEPLIRPLLDEEEETCFEVDPARLDPTEDIE 1375
Query: 635 KEKIIETNFQKLLSLAERTWKLIFETSNDLPQGIKTQLKCFRKKLEIIEPDEKISSKSLL 694
+ + L++L ++ + I +S+ P +++ C + L P+ ++ +
Sbjct: 1376 QHR------NNLIALTQKVFDAIINSSDRFPPQLRSMCHCLYQVLSKRFPN---LLQNNI 1426
Query: 695 NCISGFLFLRFFCPVILNPKIFNFVEHHPGENARRSLTLLAKVVMNLSTLTEFGSKEPWM 754
+ +FLRF P I++P+ V+ +A+R L L++K++ N++ EF SKE M
Sbjct: 1427 GAVGTVIFLRFINPAIVSPQELGIVDKQVHSSAKRGLMLMSKILQNIANHVEF-SKEQHM 1485
Query: 755 KRMNSFIDDH 764
N F+ DH
Sbjct: 1486 LCFNDFLRDH 1495
>7294865 [T] KOG2059 Ras GTPase-activating protein
Length = 1163
Score = 89.0 bits (219), Expect = 4e-17
Identities = 53/178 (29%), Positives = 89/178 (49%), Gaps = 9/178 (5%)
Query: 578 TLFRGNSILTKTMETYCYRVGQEYLDKCIGTVIRQLVEEDESYEIDPNRIKESELTEKEK 637
T+FRGN++++K M+ G YL + + V+ Q+V E + EIDP++IK+
Sbjct: 542 TIFRGNTLVSKMMDEAMRLSGLHYLHQTLRPVLSQIVAEKKPCEIDPSKIKD------RS 595
Query: 638 IIETNFQKLLSLAERTWKLIFETSNDLPQGIKTQLKCFRKKLEIIEPDEKISSKSLLNCI 697
++TN L ER ++ I ++++ P K + F E + + + +
Sbjct: 596 AVDTNLHNLQDYVERVFEAITKSADRCP---KVLCQIFHDLRECAGEHFPSNREVRYSVV 652
Query: 698 SGFLFLRFFCPVILNPKIFNFVEHHPGENARRSLTLLAKVVMNLSTLTEFGSKEPWMK 755
SGF+FLRFF P IL PK+F+ R+LTL++K + +L L S + K
Sbjct: 653 SGFIFLRFFAPAILGPKLFDLTTERLDAQTSRTLTLISKTIQSLGNLVSSRSSQQTCK 710
>Hs4557793 [V] KOG1826 Ras GTPase activating protein RasGAP/neurofibromin
Length = 2818
Score = 83.2 bits (204), Expect = 2e-15
Identities = 53/189 (28%), Positives = 98/189 (51%), Gaps = 19/189 (10%)
Query: 578 TLFRGNSILTKTMETYCYRV-GQEYLDKCIGTVIRQLVEEDE----SYEIDPNRIKESEL 632
TLFRGNS+ +K M T+C++V G YL K + ++R ++ + S+E+DP R++ SE
Sbjct: 1273 TLFRGNSLASKIM-TFCFKVYGATYLQKLLDPLLRIVITSSDWQHVSFEVDPTRLEPSES 1331
Query: 633 TEKEKIIETNFQKLLSLAERTWKLIFETSNDLPQGIKTQLKCFRKKLEIIEPDEKISSKS 692
+E N + LL + E+ + I +S++ P +++ C + + P I +
Sbjct: 1332 ------LEENQRNLLQMTEKFFHAIISSSSEFPPQLRSVCHCLYQVVSQRFPQNSIGA-- 1383
Query: 693 LLNCISGFLFLRFFCPVILNPKIFNFVEHHPGENARRSLTLLAKVVMNLSTLTEFGSKEP 752
+ +FLRF P I++P ++ P R L L++K++ +++ F +KE
Sbjct: 1384 ----VGSAMFLRFINPAIVSPYEAGILDKKPPPRIERGLKLMSKILQSIANHVLF-TKEE 1438
Query: 753 WMKRMNSFI 761
M+ N F+
Sbjct: 1439 HMRPFNDFV 1447
>Hs12545408 [T] KOG2059 Ras GTPase-activating protein
Length = 849
Score = 77.4 bits (189), Expect = 1e-13
Identities = 46/167 (27%), Positives = 83/167 (49%), Gaps = 9/167 (5%)
Query: 577 NTLFRGNSILTKTMETYCYRVGQEYLDKCIGTVIRQLVEEDESYEIDPNRIKESELTEKE 636
NT+FRGNS+ T+ ++ VG YL + ++ ++ + +S EIDP ++KE +
Sbjct: 393 NTIFRGNSLATRCLDEMMKIVGGHYLKVTLKPILDEICDSSKSCEIDPIKLKEGD----- 447
Query: 637 KIIETNFQKLLSLAERTWKLIFETSNDLPQGIKTQLKCFRKKLEIIEPDEKISSKSLLNC 696
+E N + L ++ + I ++S P + R+ P++ S
Sbjct: 448 -NVENNKENLRYYVDKLFNTIVKSSMSCPTVMCDIFYSLRQMATQRFPNDPHVQYS---A 503
Query: 697 ISGFLFLRFFCPVILNPKIFNFVEHHPGENARRSLTLLAKVVMNLST 743
+S F+FLRFF +++P F+ HHP R+LTL++K + L +
Sbjct: 504 VSSFVFLRFFAVAVVSPHTFHLRPHHPDAQTIRTLTLISKTIQTLGS 550
>CE05002 [T] KOG2059 Ras GTPase-activating protein
Length = 629
Score = 75.5 bits (184), Expect = 4e-13
Identities = 58/206 (28%), Positives = 94/206 (45%), Gaps = 16/206 (7%)
Query: 577 NTLFRGNSILTKTMETYCYRVGQEYLDKCIGTVIRQLVEEDESYEIDPNRIKESELTEKE 636
NTLFRG S+ K + G+ YL + V+ ++ +E ++ E+DP R+ EK
Sbjct: 204 NTLFRGQSLSGKMLFEILTTYGKMYLITTLKPVVDKIYKERKNCEVDPARVAVGASLEK- 262
Query: 637 KIIETNFQKLLSLAERTWKLIFETSNDLPQGIKTQLKCFRKKLEIIEPDEKISSKSLLNC 696
N LL + ++ + +S + P IK L R ++ S L
Sbjct: 263 -----NRNNLLVYFQMLFERVTTSSTNCPHLIKQLLYDLRN---VVGTHSSRSGVQRL-A 313
Query: 697 ISGFLFLRFFCPVILNPKIFNFVEHHPGENARRSLTLLAKVVMNLSTLT----EFGSKEP 752
+S F+ +RFF ILNPK F + P R+L LL+K++ LS + SKE
Sbjct: 314 VSSFVIMRFFAAAILNPKAFEIRKDQPDLRVSRTLLLLSKLLQRLSNCSVSEGPLSSKEI 373
Query: 753 WMKRMNSFI--DDHKGQLLDYLDKIT 776
W+ + + + HK + +LD I+
Sbjct: 374 WLNGVFETVTSEQHKSVMASFLDNIS 399
>Hs22062818 [T] KOG2059 Ras GTPase-activating protein
Length = 451
Score = 72.0 bits (175), Expect = 5e-12
Identities = 50/199 (25%), Positives = 96/199 (48%), Gaps = 14/199 (7%)
Query: 590 METYCYRVGQEYLDKCIGTVIRQLVEEDESYEIDPNRIKESEL---------TEKEKIIE 640
ME++ G +YL +G +I ++ EE + E+DP++++ ++ TE E ++E
Sbjct: 1 MESFLKVAGMQYLHGVLGPIINKVFEE-KYVELDPSKVEVKDVGCSGLHRPQTEAE-VLE 58
Query: 641 TNFQKLLSLAERTWKLIFETSNDLPQGIKTQLKCFRKKLEIIEPDEKISSKSLLNCISGF 700
+ Q L + + + P ++ + +++ P + + + ++ F
Sbjct: 59 QSAQTLRAHLGALLSALSRSVPACPAVVRATFRQLFRRVRERFPGAQHENVPFI-AVTSF 117
Query: 701 LFLRFFCPVILNPKIFNFVEHHPGENARRSLTLLAKVVMNLSTLTEFGS--KEPWMKRMN 758
L LRFF P I++PK+F+ E H R+L LLAK V N+ + S KE WM+ +
Sbjct: 118 LCLRFFSPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQ 177
Query: 759 SFIDDHKGQLLDYLDKITE 777
+ QL D++ K+ +
Sbjct: 178 PTVRQGVAQLKDFITKLVD 196
>SPBC646.12c [T] KOG2128 Ras GTPase-activating protein family - IQGAP
Length = 766
Score = 66.2 bits (160), Expect = 2e-10
Identities = 69/264 (26%), Positives = 122/264 (46%), Gaps = 35/264 (13%)
Query: 578 TLFRGNSILTKTMETYCYR-VGQEYLD----KCIG---------------TVIRQLVEED 617
+L R N+ +++ + TY R GQ YL +CI +V R LV
Sbjct: 192 SLLRANTPVSRMLTTYTRRGPGQAYLRSILYQCINDVAIHPDLQLDIHPLSVYRYLVNTG 251
Query: 618 E-SYEIDPNRIKESELTEKEKI---IETNFQKLLSLAERTWKLIFETSNDLPQGIKTQLK 673
+ S D N + E++E + I+ +LL L +R + + +++P GI+ K
Sbjct: 252 QLSPSEDDNLLTNEEVSEFPAVKNAIQERSAQLLLLTKRFLDAVLNSIDEIPYGIRWVCK 311
Query: 674 CFRKKLEIIEPDEKISSKSLLNCISGFLFLRFFCPVILNPKIFNFVEHHPGENARRSLTL 733
R + P IS ++ + I GF FLRF P I++P+ ++ P +N R++L
Sbjct: 312 LIRNLTNRLFPS--ISDSTICSLIGGFFFLRFVNPAIISPQTSMLLDSCPSDNVRKTLAT 369
Query: 734 LAKVVMNL-----STLTEFG-SKEPWMKRMNSFIDDHKGQLLDYLDKITEKKLD--FAPK 785
+AK++ ++ ST T S +P +K + + +L + D +LD A
Sbjct: 370 IAKIIQSVANGTSSTKTHLDVSFQPMLKEYEEKVHNLLRKLGNVGDFFEALELDQYIALS 429
Query: 786 KLKLSSSLTRPKLELSQD-ILKNL 808
K L+ +T ++ L+ + IL+NL
Sbjct: 430 KKSLALEMTVNEIYLTHEIILENL 453
>YOL081w [V] KOG1826 Ras GTPase activating protein RasGAP/neurofibromin
Length = 3079
Score = 61.6 bits (148), Expect = 6e-09
Identities = 48/212 (22%), Positives = 101/212 (47%), Gaps = 30/212 (14%)
Query: 579 LFRGNSILTKTMETYCYRVGQEYLDKCIGTVIRQLVEEDESYEIDPNRIKESELTEKEKI 638
+ R NS T+++ G EYL + + +++++++ + +EI+ + ++S+
Sbjct: 1740 ILRRNSCATRSLSMLARSKGNEYLIRTLQPLLKKIIQNRDFFEIEKLKPEDSD------- 1792
Query: 639 IETNFQKLLSLAERTWKLIFETSNDLPQGIKTQLKCFRKKLEIIEPD------EKISSKS 692
AER +L + N+L + I + F L I + EK +
Sbjct: 1793 -----------AERQIELFVKYMNELLESISNSVSYFPPPLFYICQNIYKVACEKFPDHA 1841
Query: 693 LLNCISGFLFLRFFCPVILNPKIFNFVE-HHPGENARRSLTLLAKVVMNLSTLTEFGSKE 751
++ F+FLRFFCP +++P N ++ H E +R+ LAKV+ N++ +E S+
Sbjct: 1842 II-AAGSFVFLRFFCPALVSPDSENIIDISHLSE--KRTFISLAKVIQNIANGSENFSRW 1898
Query: 752 PWMKRMNSFIDDHKGQLLDYLDKI--TEKKLD 781
P + F+ + ++ +L ++ T++ +D
Sbjct: 1899 PALCSQKDFLKECSDRIFRFLAELCRTDRTID 1930
>YBR140c [V] KOG1826 Ras GTPase activating protein RasGAP/neurofibromin
Length = 3092
Score = 60.5 bits (145), Expect = 1e-08
Identities = 116/555 (20%), Positives = 222/555 (39%), Gaps = 109/555 (19%)
Query: 255 LIYSIDVTKFLRSEIHIVDSSIFQSDKYLFMGILPQLRKQLQISSNESCFADNSRSSTKS 314
L++S D+ + I IV+ +S KY + GI+ Q+ K + + S K+
Sbjct: 1451 LLFSTDLLDAVDKLIEIVEKISIKSSKY-YKGII-QMSKMFRAFEH----------SEKN 1498
Query: 315 RKLSQYLYLRLPLRIDLEDWFVALNSFAMPDVLSLIGTDKSNELRISNRFKISILEADLR 374
+S + +L+ + WF +L I+ + L LR
Sbjct: 1499 LGISNHFHLKNKWLKLVIGWF---------------------KLSINKDYDFENLSRPLR 1537
Query: 375 DLEIEKPR---LYAEINLWD-KAVARTA------VVPSSTSPFWREEFNFNFSVRTNIIK 424
+++++K LY + ++ KA+A + PSS+ W +F I+
Sbjct: 1538 EMDLQKRDEDFLYIDTSIESAKALAYLTHNVPLEIPPSSSKEDWNRSSTVSFGNHFTILL 1597
Query: 425 IIIKCSVEDNSYS----NKDSIIGE---IQITQEMINDPNLNKETRLPVFSYTNKNFQIG 477
++ S + N + +K SI+ E I +T + N++ + LP+ NK+ +I
Sbjct: 1598 KGLEKSADLNQFPVSLRHKISILNENVIIALTNLSNANVNVSLKFTLPMGYSPNKDIRIA 1657
Query: 478 TICIKTISSLNFVLQPVNFTKFEQVLSKVSLPKICDYMHDSKI-----SADLKLEDISLV 532
+ + N+ PVN K E +++ Y+ + I S D+ L
Sbjct: 1658 FLRVFIDIVTNY---PVNPEKHEMD-KMLAIDDFLKYIIKNPILAFFGSLACSPADVDLY 1713
Query: 533 ---FLDIFQAINREDDWFQALIDREFQGLDKSITMSNSNHQSSNHIYNTLFRGNSILTKT 589
FL+ F N L+ +E + +S + + R NS T+
Sbjct: 1714 AGGFLNAFDTRNASHILVTELLKQEIKRAARS---------------DDILRRNSCATRA 1758
Query: 590 METYCYRVGQEYLDKCIGTVIRQLVEEDESYEIDPNRIKESELTEKEKIIETNFQKLLSL 649
+ Y G +YL K + V++ +V+ ES+EID K K N +K+L L
Sbjct: 1759 LSLYTRSRGNKYLIKTLRPVLQGIVDNKESFEID-----------KMKPGSENSEKMLDL 1807
Query: 650 AERTWKLIFETSNDLPQGIKTQLKCFRKKLEIIEPDEKISSKSLLN-------CISGFLF 702
E+ + + I + + F +E+++ + I + + +N + F+F
Sbjct: 1808 FEKYMTRLID-------AITSSIDDF--PIELVDICKTIYNAASVNFPEYAYIAVGSFVF 1858
Query: 703 LRFFCPVILNPKIFN--FVEHHPGENARRSLTLLAKVVMNLSTLTEFGSKEPWMKRMNSF 760
LRF P +++P N V H + R+ LAKV+ +L+ E K+ + F
Sbjct: 1859 LRFIGPALVSPDSENIIIVTH---AHDRKPFITLAKVIQSLANGRENIFKKDILVSKEEF 1915
Query: 761 IDDHKGQLLDYLDKI 775
+ ++ ++L ++
Sbjct: 1916 LKTCSDKIFNFLSEL 1930
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.317 0.134 0.381
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 60,587,368
Number of Sequences: 60738
Number of extensions: 2647611
Number of successful extensions: 7885
Number of sequences better than 1.0e-05: 28
Number of HSP's better than 0.0 without gapping: 18
Number of HSP's successfully gapped in prelim test: 10
Number of HSP's that attempted gapping in prelim test: 7786
Number of HSP's gapped (non-prelim): 51
length of query: 1046
length of database: 30,389,216
effective HSP length: 117
effective length of query: 929
effective length of database: 23,282,870
effective search space: 21629786230
effective search space used: 21629786230
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)