ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactII1885 good TU KOG1786 Intracellular trafficking, secretion, and vesicular transport Lysosomal trafficking regulator LYST and related BEACH and WD40 repeat proteins
r_klactII1885 good TU KOG1786 Signal transduction mechanisms Lysosomal trafficking regulator LYST and related BEACH and WD40 repeat proteins
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactII1885 667863 673859 1999
(1999 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YCR032w [TU] KOG1786 Lysosomal trafficking regulator LYST and re... 639 0.0
Hs22044271 [TU] KOG1786 Lysosomal trafficking regulator LYST and... 382 e-105
CE20122 [TU] KOG1786 Lysosomal trafficking regulator LYST and re... 367 e-101
At4g02660_2 [TU] KOG1786 Lysosomal trafficking regulator LYST an... 345 6e-94
At1g03060_2 [TU] KOG1786 Lysosomal trafficking regulator LYST an... 340 1e-92
7290560 [U] KOG1787 Kinase A-anchor protein Neurobeachin and rel... 327 1e-88
Hs22050699 [TU] KOG1786 Lysosomal trafficking regulator LYST and... 323 1e-87
Hs22051940 [U] KOG1787 Kinase A-anchor protein Neurobeachin and ... 322 5e-87
Hs21536252 [U] KOG1787 Kinase A-anchor protein Neurobeachin and ... 322 5e-87
Hs16904381 [U] KOG1787 Kinase A-anchor protein Neurobeachin and ... 320 1e-86
Hs22042385 [U] KOG1787 Kinase A-anchor protein Neurobeachin and ... 310 2e-83
Hs4502839 [TU] KOG1786 Lysosomal trafficking regulator LYST and ... 307 1e-82
At2g45540 [U] KOG1787 Kinase A-anchor protein Neurobeachin and r... 301 5e-81
CE00946 [U] KOG1787 Kinase A-anchor protein Neurobeachin and rel... 290 2e-77
At1g58240 [U] KOG1787 Kinase A-anchor protein Neurobeachin and r... 284 9e-76
Hs4505465_2 [TU] KOG1786 Lysosomal trafficking regulator LYST an... 266 2e-70
7292187 [TU] KOG1786 Lysosomal trafficking regulator LYST and re... 261 8e-69
7292461 [TU] KOG1786 Lysosomal trafficking regulator LYST and re... 255 4e-67
CE03607 [TU] KOG1786 Lysosomal trafficking regulator LYST and re... 197 1e-49
At3g60920 [U] KOG1787 Kinase A-anchor protein Neurobeachin and r... 146 3e-34
HsM7657363 [U] KOG1787 Kinase A-anchor protein Neurobeachin and ... 123 3e-27
At5g18530 [TU] KOG1786 Lysosomal trafficking regulator LYST and ... 105 6e-22
7297900_1 [TU] KOG1786 Lysosomal trafficking regulator LYST and ... 86 8e-16
>YCR032w [TU] KOG1786 Lysosomal trafficking regulator LYST and related BEACH
and WD40 repeat proteins
Length = 2167
Score = 639 bits (1648), Expect = 0.0
Identities = 500/1715 (29%), Positives = 834/1715 (48%), Gaps = 150/1715 (8%)
Query: 364 GKCSYYQTSDIVGLLLNMNVMETFLHRLIVEKDSSSIRIMTSHIIKYLKNSAMDNHFQSI 423
GKC +Y++S++V ++++ + + + SH++ L+N + N F+
Sbjct: 456 GKCYFYRSSNLVSKFVSIDSIRLAFLNMTESGSIDDLFHHVSHLMNLLRNIDILNWFKKD 515
Query: 424 QGNLVLNYILTLKAEIGNIIDIKVVEDLTELFTLMNTNTIIEE-----NFIAESPL---- 474
G + Y TLK K+ +DL++ + N +E N I++S +
Sbjct: 516 FGFPLFAY--TLKQ--------KITQDLSQPLNIQFFNLFLEFCGWDFNDISKSIILDTD 565
Query: 475 ---KILLNFRL--------------IPLVDVAVFEQLFIGLSSIFNKHSSRNVNSISEGI 517
I+LN L + ++ F+ + +SI++K +S N ++
Sbjct: 566 AYENIVLNLDLWYMNEDQSSLASGGLEIIRFLFFQISSLMEASIYSKFNSNKFNDMN--- 622
Query: 518 TILQRTILFQLHSSFDTNDLNVIISDCAKSLKNLLDILLYCNIRNDGTIVHLQFSYFCLK 577
IL++ L + + N ++ + L ++ LL N L SY+ +K
Sbjct: 623 -ILEKLCL-SYQAVTKRENQNSKFNELSSDLISVFVTLLKSNTDKRHLQWFLHLSYYFIK 680
Query: 578 KGHITLAKVLLESLDSVFTQYQIDDRDFLCKSIPINLYVKVIFILMQSSIQHLEILKVA- 636
+ + +++L+++D +F+ Y D K + + +K+I ++M +++ E +
Sbjct: 681 RKDVRSTEIILQAVDQLFSFYLDQGSDENAKILSEIIPLKLILMIMDQIVENNESNPITC 740
Query: 637 YSILLKLFDKQPGFFAQFTNSNGYKXXXXXX-XXXXXXEAELLTTILNVSASKGTVKRDL 695
+IL K+ F QF ++G K E+++ +L S T ++
Sbjct: 741 LNILFKVVLTNKPLFKQFYKNDGLKLILTMLCKVGKSYREEIISLLLTYSIGNYTTANEI 800
Query: 696 FYKNILSPPDDGISLFSHSVV-----INLLDSFIK-----------RNPFAIQEFLLTFI 739
F S +D I S+ + I L +FI+ + + +L F+
Sbjct: 801 F-----SGAEDMIGGISNDKITAKEIIYLAVNFIEWHVINSNASDSSSVLDLNNHILRFV 855
Query: 740 EYLKKMHQRNPNHILFTSPYPIIQ-SIFGLQMNL-EMLAVEKLLPTVNVCNKSLLADIIV 797
E LK + N +F + S+ L + L E + K + V ++ + +I+
Sbjct: 856 EDLKSLSAVPINESVFDPKKSYVMVSLLDLSIALNESEDISKFKSSSKVISELIKGNIMC 915
Query: 798 QKMKTYDPESFKTLLSYIVSYSENSKR--PKS---SQICQKMGLVFLIVPRILKRLSALS 852
K Y F+ +S +S K PK+ + ++ + ++P IL L +
Sbjct: 916 ALTK-YAAYDFEVYMSTFFCHSTEYKLVYPKTVMNNSSYLELSFIVTLLPEILNDLVDSN 974
Query: 853 FTVEKDHSKLVF-VENILHLVSISSASWKVHDASWEALINTNLVILKARELISKSDFESS 911
+ K + + N+L+ + + ++ +L I KS F
Sbjct: 975 NNLNLMMLKHPYTMSNLLYFLRKFRPDTSQIVMPKDFYFSSYTCLLHCVIQIDKSSFYHF 1034
Query: 912 FQTDILRNLNSVQEEIYNWIVANGIRKDSNIEHDMIEQLLHAMLYYQEVLFIERHKETTL 971
+ L + I N I +N + K E + E +++ +QEVLF
Sbjct: 1035 KNVSKSQLLQDFKICIMNLIYSNTL-KQIIWEKEEYEMFSESLMAHQEVLFAHG----AC 1089
Query: 972 SNEVLANILTFIRRVILMSEPHVQFLGLNVFRTICTLRDASLPSISKTCTNE---SSKCF 1028
NE + +L F + + N + I ++ L ++ C + S+
Sbjct: 1090 DNETVGLLLIFFAN--RLRDCGYNKAVFNCMKVIIKNKERKLKEVA--CFFDPANKSEVL 1145
Query: 1029 EFLAKSVKSDDDTLLQALRDATSNVLFSKSVKRLQTLYKMDGIRMDGHRRVSRSQLTHIL 1088
E L+ + ++ + + + + R + + + +S Q+ + +
Sbjct: 1146 EGLSNILSCNNSETMNLITEQYPFFFNNTQQVRFINIVTNILFKNNNFSPISVRQIKNQV 1205
Query: 1089 FKERTDEYDRSIIDSNSIYALFKKDNVNLTKKMVLIEERRLNDY---LADDRYQKEAGYA 1145
++ + + ++ LF+KDN +L K+ ++ ++ Y L DR + Y
Sbjct: 1206 YEWKNARSEYVTQNNKKCLILFRKDNTSLDFKI----KKSISRYTYNLKTDREENAVFYR 1261
Query: 1146 CALRV-IRKVASTAYLRDF-KSTREWYLAARENVKRQRIQLLPVFEPIDFLPSLKLKLQD 1203
L + I + T ++ S+ +W E+ + +LLP +EP + P + + +
Sbjct: 1262 NNLNLLIFHLKHTLEIQSNPNSSCKWSSDFAEDFDGMKRRLLPAWEP-KYEPLINEEDAN 1320
Query: 1204 IHKHRAALPHSDTASTIISTQDLNVDVESEGSDQFALDKNRAVLQLLRKDERILNIWNAS 1263
+ +I+S + + E L++NR +L+LL+ ++ I IWN S
Sbjct: 1321 QDTITGGNRQRRESGSILSYEFIEHMETLESEPVGDLNENRKILRLLKDNDSIATIWNCS 1380
Query: 1264 HIIGLLAKPGVLVLTTSSLYFISGCYYDSNEKKVLDLDALPEILRDLTIDSLSADLITKS 1323
IIGL K G+L+ ++ LYF+S Y+ +KK+L L + + RD+T+ ++ + +
Sbjct: 1381 LIIGLEIKEGILIHGSNYLYFVSDYYFSLEDKKILKLSEVSQESRDMTVSLINGPDVKR- 1439
Query: 1324 IEADAEIESLRYGWKVKTLNRTIKRPFLLRDTAMELFFGLKNTIMFSFKDQSIRDDVFST 1383
++ + WK+ + KRPFLLRD A+EL F + + FSF ++ +RDDV
Sbjct: 1440 --VSTFLKHEVFVWKLLDITFVTKRPFLLRDVAIELLFKERVSAFFSFYNKRVRDDVLRV 1497
Query: 1384 LKKYAKDDKHDSIWSSILEEVNFKSNVLSSKNGISRTSISDKVSAAFTSITKYHASEKIL 1443
L K K D I+SS+L+E+N + N + ++NGI + SI+ K ++ F++ +I
Sbjct: 1498 LNKIPKHLPADPIFSSVLQEINDRGNSIVARNGIGKASIASKFTSVFSANNSLIDGFEIS 1557
Query: 1444 DLWQAGSLSNFDYLMALNTLAGRTFNDLTQYPVFPWVIADYVSDSIDLENPKTYRDLSKP 1503
W G +SNF YL+++N LAGR+FNDLTQYPVFPWVIADY S+ +DLENPKTYRDLSKP
Sbjct: 1558 KKWVRGEISNFYYLLSINILAGRSFNDLTQYPVFPWVIADYESNVLDLENPKTYRDLSKP 1617
Query: 1504 MGAQSEKRMMNFIERFQALKDLDDTSTPPFHYGTHYSSAMIVSSYLVRLQPFADTYKTLQ 1563
MGAQSEKR + FIER++AL L++ + PFHYGTHYSSAMIVSSYL+RL+PF +++ LQ
Sbjct: 1618 MGAQSEKRKLQFIERYEALASLENADSAPFHYGTHYSSAMIVSSYLIRLKPFVESFLLLQ 1677
Query: 1564 GDQWGPPDRLFNSVSRAWTSASSEASTDVRELIPEFYYLPDFLTNKNSYNFGTTQNGKEV 1623
G +GP DRLF+S+ RAW+SASSE +TDVREL PEF++LP+FL N NSY+FGT Q+GK+V
Sbjct: 1678 GGSFGPADRLFSSLERAWSSASSENTTDVRELTPEFFFLPEFLINVNSYDFGTDQSGKKV 1737
Query: 1624 TDVALPPWAKNDPKIFIEINRQALESRYVSEHLNEWIDLVFGFKQRGKEAIKAVNVFNSL 1683
DV LPPWA DPK+FI+ NR+ALES YVS HL+EWIDL+FG+KQ+G A+K+VNVFN L
Sbjct: 1738 DDVVLPPWANGDPKVFIQKNREALESPYVSAHLHEWIDLIFGYKQKGDIAVKSVNVFNRL 1797
Query: 1684 SYSGNVDINGIDNDIERKAITGIIHNFGQTPLQIFQHPHPPRKCKAYLEVEDEDVRKFGD 1743
SY G V+++ ID++ ER+AITGIIHNFGQTPLQIFQ PHP + ++ E RK
Sbjct: 1798 SYPGAVNLDNIDDENERRAITGIIHNFGQTPLQIFQEPHPEKIACNVQQLTTEVWRKV-P 1856
Query: 1744 LKPSI----------NRTAD--------------------------KQSCICLPSISHRD 1767
+KP NR+ D ++S + L +
Sbjct: 1857 MKPIFEKTIFNLNEKNRSVDYVIHDPSYFDSLYWRGFAFPNLFFRTEESLVSLRIVHKNW 1916
Query: 1768 IKLKNGGVKHAHSSKITVLSNFDQSLIATGDSIGLIKLWRTSKD------GLTFLRCFCG 1821
+K+ K H ++IT + + TGD GLIK+W+ KD L + G
Sbjct: 1917 LKIGLDIFKKTHMAQITSFAYWKLGEFITGDKNGLIKVWKYRKDKHSVSGNLENKKTMFG 1976
Query: 1822 HESSIKSIRASLQCDTIISLDTHGTTIVWDLKNGTVINKFSIMAKLVAISPTTGSVSI-A 1880
H +K +R +T+++LD G VWD+ N ++ + + A+ VAIS GS+ +
Sbjct: 1977 HLCELKEMRCYHDYNTLLTLDISGLVYVWDMINFELVRQITNDAQKVAISQHAGSIMVLT 2036
Query: 1881 GEKGISIFDLNGSIYC--LHETAEEISAIAFMDRDV----FWPYKYHEKLDTVLVA-TGN 1933
ISIF+LNG IY E A+ +S+I F D + + Y ++++ +LV
Sbjct: 2037 KNNAISIFNLNGQIYTSKKFEPAKIVSSIDFFDFTKLDAGYRKHIYWKEMEILLVGFEDG 2096
Query: 1934 KITVYD-FKLVQQKWKLLPQQSISNHQVKSIVDIK 1967
I +Y+ F +W + + + + K+I IK
Sbjct: 2097 TIEIYELFLNFHNEWAIKLLKQLCTEKGKAITSIK 2131
Score = 135 bits (339), Expect = 9e-31
Identities = 91/293 (31%), Positives = 152/293 (51%), Gaps = 15/293 (5%)
Query: 32 NSYENTASKD--ELYTYTTFEISQRFNNIEPTELNFVYDDTSKWEKLLSHQSSELSYIIA 89
NS + T D EL YT F +S+ F+ + NF +W +LL + +S+ +
Sbjct: 66 NSKKGTVEDDLCELNNYTCFALSKSFDLCHDSR-NFNIAQPKRWIQLLETLTDSVSFAVI 124
Query: 90 LHIVLCLIENSIVNKQSFAKHPAMKSFVKARLRGNEMDP----LLNATFGELYCHVFAIQ 145
+ I+L L S++NKQ+ K ++ + + N+ D LL E Y + ++
Sbjct: 125 VQIILTLSNISLINKQTLGKLKKLRIRI-FEILSNKNDSWKSTLLQKNLIEWYIFMLSVD 183
Query: 146 ANAEDIRFVY-ENTYPYDWNIVENIASQITDQSMQTHLLFENCYLTFA---NLKIPNSFT 201
+++ +Y + I+ ++ Q++D Q +L FEN Y F + +I NSF
Sbjct: 184 CTPLELQNLYLHKELKFCNGILNSLTLQVSDPRSQNYLQFENTYKLFQIQKSSRINNSFL 243
Query: 202 LQVTLELLNTTSNRVITLGKNTYLEIRDTHICISNDEFITALFDGFEFEIGVIYSMILCF 261
+ E + TSNR++T+ ++ YLEI++ CISND +I LF+ FEFE G +Y + +
Sbjct: 244 FYI--EFNSVTSNRIMTIERHIYLEIKEGQFCISNDNYIIGLFENFEFEAGTLYFIGVLI 301
Query: 262 DAGS-VTLFVDHVFIQTIPLVSDSIEDLSTVELGSMLSFFAVFKFTILDYCIT 313
D + +TL+VD I + L +SI LST ELGSM+ V++F + D +T
Sbjct: 302 DHNNRITLYVDGSMINQLTLFENSICQLSTCELGSMICSIKVYRFYLWDGLLT 354
>Hs22044271 [TU] KOG1786 Lysosomal trafficking regulator LYST and related BEACH
and WD40 repeat proteins
Length = 1513
Score = 382 bits (982), Expect = e-105
Identities = 238/729 (32%), Positives = 390/729 (52%), Gaps = 99/729 (13%)
Query: 1229 DVESEGSDQFALDK--NRAVLQLLRKDERILNIWNASHIIGLLAKPGVLVLTTSSLYFIS 1286
D +EGS +K N +L+LL + E+I +++ + + GL G+L+ Y I
Sbjct: 494 DQIAEGSSIEEEEKTDNATLLRLLEEGEKIQHMYRCARVQGLDTSEGLLLFGKEHFYVID 553
Query: 1287 GCYYDSNEKKVLDLDALPEILRDLTIDSLSADLITKSIEADAEIESLRYGWKVKTLNRTI 1346
G + + +++ D++ LP + + I + + ++++ + + +
Sbjct: 554 G-FTMTATREIRDIETLPPNMHEPIIPRGAR-------QGPSQLKRTCSIFAYEDIKEVH 605
Query: 1347 KRPFLLRDTAMELFFGLKNTIMFSFKDQSIRDDVFSTLKKYAKDDKHDSIWSSILEEVNF 1406
KR +LL+ A+E+F G + +F+ + IR+ V+ + +++ +
Sbjct: 606 KRRYLLQPIAVEVFSGDGRNYLLAFQ-KGIRNKVYQR-------------FLAVVPSLTD 651
Query: 1407 KSNVLSSKNGISRTSISDKVSAAFTSITKYHASEKILDLWQAGSLSNFDYLMALNTLAGR 1466
S +S + TS+ T + + +++ W+ G +SNF YLM LNTLAGR
Sbjct: 652 SSESVSGQR--PNTSVEQGSGLLSTLVGEKSVTQR----WERGEISNFQYLMHLNTLAGR 705
Query: 1467 TFNDLTQYPVFPWVIADYVSDSIDLENPKTYRDLSKPMGAQSEKRMMNFIERFQALKDLD 1526
++NDL QYPVFPW++ADY S+ +DL NPKT+R+L+KPMGAQ+++R+ + +R++ +D
Sbjct: 706 SYNDLMQYPVFPWILADYDSEEVDLTNPKTFRNLAKPMGAQTDERLAQYKKRYKDWED-P 764
Query: 1527 DTSTPPFHYGTHYSSAMIVSSYLVRLQPFADTYKTLQGDQWGPPDRLFNSVSRAWTSASS 1586
+ TP +HYGTHYSSAMIV+SYLVR++PF + LQG + DR+F+SV AW SAS
Sbjct: 765 NGETPAYHYGTHYSSAMIVASYLVRMEPFTQIFLRLQGGHFDLADRMFHSVREAWYSASK 824
Query: 1587 EASTDVRELIPEFYYLPDFLTNKNSYNFGTTQNGKEVTDVALPPWAKNDPKIFIEINRQA 1646
DV+ELIPEF+YLP+FL N N+++ G QNG ++ DV LPPWAK DP+ FI ++R+A
Sbjct: 825 HNMADVKELIPEFFYLPEFLFNSNNFDLGCKQNGTKLGDVILPPWAKGDPREFIRVHREA 884
Query: 1647 LESRYVSEHLNEWIDLVFGFKQRGKEAIKAVNVFNSLSYSGNVDINGIDNDIERKAITGI 1706
LE YVS HL+EWIDL+FG+KQ+G A++AVNVF+ L Y G VDI I++ ++ A G
Sbjct: 885 LECDYVSAHLHEWIDLIFGYKQQGPAAVEAVNVFHHLFYEGQVDIYNINDPLKETATIGF 944
Query: 1707 IHNFGQTPLQIFQHPHPPRKCKAYLEVEDEDV-------------RKFGDLKPSINRT-- 1751
I+NFGQ P Q+F+ PHPP++ ++ L ++ + +L+PS+
Sbjct: 945 INNFGQIPKQLFKKPHPPKRVRSRLNGDNAGISVLPGSTSDKIFFHHLDNLRPSLTPVKE 1004
Query: 1752 ----------------ADKQSCICLP-------SISHRDIKLKNGGVKHAHSSKI-TVLS 1787
A +Q+ + +P + + D+ + G + + + LS
Sbjct: 1005 LKEPVGQIVCTDKGILAVEQNKVLIPPTWNKTFAWGYADLSCRLGTYESDKAMTVYECLS 1064
Query: 1788 NFDQ---------SLIATGDSIGLIKLWR--TSKD---GLTFLRCFCGHESSIKSIRASL 1833
+ Q L+ TG + ++ +W TSK+ +T + GH ++ ASL
Sbjct: 1065 EWGQILCAICPNPKLVITGGTSTVVCVWEMGTSKEKAKTVTLKQALLGHTDTVTCATASL 1124
Query: 1834 QCDTIISLDTHGTTIVWDLKNGTVINKFSIMAKL---------VAISPTTGSVSIAGEKG 1884
I+S T I+WDL NK S + +L + I+ TG +
Sbjct: 1125 AYHIIVSGSRDRTCIIWDL------NKLSFLTQLRGHRAPVSALCINELTGDIVSCAGTY 1178
Query: 1885 ISIFDLNGS 1893
I ++ +NG+
Sbjct: 1179 IHVWSINGN 1187
>CE20122 [TU] KOG1786 Lysosomal trafficking regulator LYST and related BEACH
and WD40 repeat proteins
Length = 931
Score = 367 bits (943), Expect = e-101
Identities = 236/697 (33%), Positives = 347/697 (48%), Gaps = 73/697 (10%)
Query: 1259 IWNASHIIGLLAKPGVLVLTTSSLYFISGCYYDSNEKKVLDLDALPEILRDLTIDSLSAD 1318
++ + I GL G+L+ Y + G + K++ DLD L + + D I A
Sbjct: 1 MFRCARIQGLETAEGLLLFGRDHFYVVDG-FTLLKTKEIRDLDFLSQEMHD-PIVPYPAT 58
Query: 1319 LITKSIEADAEIESLRYGWKVKTLNRTIKRPFLLRDTAMELFFGLKNTIMFSFKDQSIRD 1378
T+ ++ Y + KR +LL+ A+E+F + +F + IRD
Sbjct: 59 GATQPPKSSRLCSKFSYNM----IREVHKRRYLLQPIALEVFSSDGRNYLLAFP-KKIRD 113
Query: 1379 DVFSTLKKYAKDDKHDSIWSSILEEVNFKSNVLSSKNGISRTSISDKVSAAFTSITKYHA 1438
VF L A +N S S G + + ++
Sbjct: 114 RVFDKLTSMA---------------INLSSGGSDSLGGQKANVAIETTGRGASLLSSLIG 158
Query: 1439 SEKILDLWQAGSLSNFDYLMALNTLAGRTFNDLTQYPVFPWVIADYVSDSIDLENPKTYR 1498
+ + W +G++SNF YLM LNTLAGR +NDL+QYP+FPWV+ADY S +D N T+R
Sbjct: 159 QQSVTQRWLSGNISNFQYLMHLNTLAGRCYNDLSQYPIFPWVLADYTSSQLDFNNISTFR 218
Query: 1499 DLSKPMGAQSEKRMMNFIERFQALKDLDDTS--TPPFHYGTHYSSAMIVSSYLVRLQPFA 1556
D SKPMGAQS R+ F++RF ++ DD S TPP+ YGTHYSSAMIV SYLVRL+PF
Sbjct: 219 DFSKPMGAQSPDRLEQFLKRF---REWDDPSGETPPYMYGTHYSSAMIVVSYLVRLEPFT 275
Query: 1557 DTYKTLQGDQWGPPDRLFNSVSRAWTSASSEASTDVRELIPEFYYLPDFLTNKNSYNFGT 1616
+ +LQG + DR+F+SV AWTSAS DV+ELIPEF+ LP+ TN N ++ G
Sbjct: 276 QQFLSLQGGHFDLADRMFHSVGDAWTSASRNNMADVKELIPEFFTLPEMFTNTNHFDLGV 335
Query: 1617 TQNGKEVTDVALPPWAKNDPKIFIEINRQALESRYVSEHLNEWIDLVFGFKQRGKEAIKA 1676
QNG V DV LP W DP+ FI ++RQALES YVS HL+EWIDL+FG+KQ G+EA+K
Sbjct: 336 KQNGIHVNDVLLPAWCHGDPREFIRLHRQALESDYVSSHLHEWIDLIFGYKQNGEEAVKN 395
Query: 1677 VNVFNSLSYSGNVDINGIDNDIERKAITGIIHNFGQTPLQIFQHPHPPRKCKA------- 1729
N+F+ L Y G+VD ID+ + R A G ++NFGQ P Q+F+ PHP +K
Sbjct: 396 SNLFHHLFYEGSVDFERIDDPLTRNATIGFVNNFGQIPTQLFKKPHPQKKVNILEGFSNT 455
Query: 1730 ---------YLEVEDEDVRK--FGDLKPSIN--RTADKQSCIC----------------- 1759
Y + + + F +L+ +I DK +
Sbjct: 456 PGVTTSRLFYHAIHNMSAPQTPFKELRSAIGSIHQNDKIGVVALEQNKVFIGTNRYITWG 515
Query: 1760 LPSISHRDIKLKNGGVKHAHS----SKITVLSNFDQSLIATGDSIGLIKLWRTSKDGLTF 1815
LP S R ++ N H ++T + D++ + G++ G I +W+ + L+
Sbjct: 516 LPDRSVRMGQIDNDKSVCVHEMCEVDEMTCAAAGDETTLFCGNTSGCITVWKVNNKPLSM 575
Query: 1816 --LRCFCGHESSIKSIRASLQCDTIISLDTHGTTIVWDLKNGTVIN---KFSIMAKLVAI 1870
L GH +I + + ++S T +VW L +I K VA+
Sbjct: 576 KKLSVLNGHSDAITCLVSCQSHAVLVSASRDLTVLVWHLSEMFLIRQLPKHPHAVLAVAV 635
Query: 1871 SPTTGSVSIAGEKGISIFDLNGSIYCLHETAEEISAI 1907
+ TG ++ A + ++ LNG + + T + AI
Sbjct: 636 NDATGDIATACSTLLHVWTLNGELLAVLNTCDVAPAI 672
>At4g02660_2 [TU] KOG1786 Lysosomal trafficking regulator LYST and related BEACH
and WD40 repeat proteins
Length = 643
Score = 345 bits (884), Expect = 6e-94
Identities = 217/605 (35%), Positives = 320/605 (52%), Gaps = 71/605 (11%)
Query: 1342 LNRTIKRPFLLRDTAMELFF--GLKNTIMFSFKDQSIRDDVFSTLKKYAKDDKHDSIWSS 1399
++ +KR + LR A+E+F G + ++F K+ R++VF L +S
Sbjct: 1 VHEILKRDYELRRVAVEIFSMDGCNDLLVFHKKE---REEVFRNLLAMNLPR------NS 51
Query: 1400 ILEEVNFKSNVLSSKNGISRTSISDKVSAAFTSITKYHASEKILDLWQAGSLSNFDYLMA 1459
+L+ S SK G + K S TK WQ G +SNF YLM
Sbjct: 52 MLDTTISGSAKQESKEGSRLFKLMAK------SFTKR---------WQNGEISNFQYLMH 96
Query: 1460 LNTLAGRTFNDLTQYPVFPWVIADYVSDSIDLENPKTYRDLSKPMGAQSEKRMMNFIERF 1519
LNTLAGR ++DLTQYPVFPW++ADY +S+DL +P +R L KPMG Q+ + F +R+
Sbjct: 97 LNTLAGRGYSDLTQYPVFPWILADYDGESLDLSDPNNFRKLDKPMGCQTPEGEEEFRKRY 156
Query: 1520 QALKDLDDTSTPPFHYGTHYSSAMIVSSYLVRLQPFADTYKTLQGDQWGPPDRLFNSVSR 1579
++ DD P FHYG+HYSSA IV YL+RL PF+ + LQG Q+ DRLFNS+
Sbjct: 157 ESW---DDPEVPQFHYGSHYSSAGIVLFYLIRLPPFSAENQKLQGGQFDHADRLFNSIRE 213
Query: 1580 AWTSASSEAST-DVRELIPEFYYLPDFLTNKNSYNFGTTQNGKEVTDVALPPWAKNDPKI 1638
W SA+ + +T DV+ELIPEF+Y+P+FL N+ + + G Q+G +V DV LPPWA+ +
Sbjct: 214 TWLSAAGKGNTSDVKELIPEFFYMPEFLENRFNLDLGEKQSGDKVGDVILPPWARGSVRE 273
Query: 1639 FIEINRQALESRYVSEHLNEWIDLVFGFKQRGKEAIKAVNVFNSLSYSGNVDINGIDNDI 1698
FI +R+ALES YVSE+L+ WIDL+FG KQRGK A AVNVF +Y GNVD++ + +
Sbjct: 274 FIRKHREALESDYVSENLHHWIDLIFGHKQRGKAAENAVNVFYHYTYEGNVDVDAVTDPA 333
Query: 1699 ERKAITGIIHNFGQTPLQIFQHPH---------PPRKCKAYLEVEDEDVRKFGDLKPSIN 1749
+ +I I++FGQTP Q+FQ PH PP K + + ++RK I
Sbjct: 334 MKASILAQINHFGQTPKQLFQKPHVKRRTDRKVPPHPLKHSMHLVPRNIRKCSSSINQII 393
Query: 1750 RTADK-----QSCICLPS-----------------ISHRDIKLKNGGVKHAHSSKITVLS 1787
DK +C+ P +S+ KL + ++I
Sbjct: 394 TFNDKLLLTGANCLLKPRGYKKYIRWGFPDRTLRFMSYDQDKLLSTHENLHEGNQIQCAG 453
Query: 1788 -NFDQSLIATGDSIGLIKLWRTSKDG------LTFLRCFCGHESSIKSIRASLQCDTIIS 1840
+ D ++ TG GL+ +WR SKDG L + C H + + +R S I S
Sbjct: 454 VSHDGRIVVTGAEDGLVSVWRVSKDGPRGSRRLRLEKSLCAHTAKVICLRVSQPYMMIAS 513
Query: 1841 LDTHGTTIVWDLKNGTVINK---FSIMAKLVAISPTTGSVSIAGEKGISIFDLNGSIYCL 1897
T I+WDL + + + + FS+ +V I+ TG + A ++++ +NG +
Sbjct: 514 SSDDCTVIIWDLSSLSFVRQLPNFSVPVTVVYINDLTGEIVTAAGSVLAVWSINGDCLSV 573
Query: 1898 HETAE 1902
T++
Sbjct: 574 VNTSQ 578
>At1g03060_2 [TU] KOG1786 Lysosomal trafficking regulator LYST and related BEACH
and WD40 repeat proteins
Length = 717
Score = 340 bits (873), Expect = 1e-92
Identities = 213/605 (35%), Positives = 321/605 (52%), Gaps = 71/605 (11%)
Query: 1342 LNRTIKRPFLLRDTAMELFF--GLKNTIMFSFKDQSIRDDVFSTLKKYAKDDKHDSIWSS 1399
++ +KR + LR A+E+F G + ++F K+ R++VF L
Sbjct: 1 VHEILKRDYQLRPVAIEIFSMDGCNDLLVFHKKE---REEVFKNLVAMNLP--------- 48
Query: 1400 ILEEVNFKSNVLSSKNGISRTSISDKVSAAFTSITKYHASEKILDLWQAGSLSNFDYLMA 1459
++++L + S S++ F + K + WQ G +SNF YLM
Sbjct: 49 -------RNSMLDTTISGSAKQESNEGGRLFKLMAKSFSKR-----WQNGEISNFQYLMH 96
Query: 1460 LNTLAGRTFNDLTQYPVFPWVIADYVSDSIDLENPKTYRDLSKPMGAQSEKRMMNFIERF 1519
LNTLAGR ++DLTQYPVFPWV+ADY S+S+D +PKT+R L KPMG Q+ + F +R+
Sbjct: 97 LNTLAGRGYSDLTQYPVFPWVLADYDSESLDFSDPKTFRKLHKPMGCQTPEGEEEFRKRY 156
Query: 1520 QALKDLDDTSTPPFHYGTHYSSAMIVSSYLVRLQPFADTYKTLQGDQWGPPDRLFNSVSR 1579
++ DD P FHYG+HYSSA IV YL+RL PF+ + LQG Q+ DRLFNS+
Sbjct: 157 ESW---DDPEVPKFHYGSHYSSAGIVLFYLIRLPPFSSENQKLQGGQFDHADRLFNSIKD 213
Query: 1580 AWTSASSEAST-DVRELIPEFYYLPDFLTNKNSYNFGTTQNGKEVTDVALPPWAKNDPKI 1638
W SA+ + +T DV+ELIPEF+Y+P+FL N+ S + G Q+G++V DV LPPWA+ +
Sbjct: 214 TWLSAAGKGNTSDVKELIPEFFYMPEFLENRFSLDLGEKQSGEKVGDVFLPPWARGSVRE 273
Query: 1639 FIEINRQALESRYVSEHLNEWIDLVFGFKQRGKEAIKAVNVFNSLSYSGNVDINGIDNDI 1698
FI +R+ALES YVSE+L+ WIDL+FG+KQRGK A +AVNVF +Y GNVDI+ + +
Sbjct: 274 FILKHREALESDYVSENLHHWIDLIFGYKQRGKAAEEAVNVFYHYTYEGNVDIDAVTDPA 333
Query: 1699 ERKAITGIIHNFGQTPLQIFQHPHPPRK---------CKAYLEVEDEDVRKFGDLKPSIN 1749
+ +I I++FGQTP Q+F H R+ K + + ++RK I
Sbjct: 334 MKASILAQINHFGQTPKQLFPKAHVKRRTDRKIPLHPLKHSMHLVPHEIRKCSSSISQII 393
Query: 1750 RTADK-----QSCICLPS-----------------ISHRDIKLKNGGVKHAHSSKITVLS 1787
DK +C P +S+ KL + S++I
Sbjct: 394 TFHDKVLVAGANCFLKPRGYTKYITWGFPDRSLRFMSYDQDKLLSTHENLHESNQIQCAG 453
Query: 1788 -NFDQSLIATGDSIGLIKLWRTSKDG------LTFLRCFCGHESSIKSIRASLQCDTIIS 1840
+ D ++ TG GL+ +WR SKDG L + C H + + +R S I S
Sbjct: 454 VSHDGRIVVTGAEDGLVCVWRVSKDGPRGSRRLRLEKALCAHTAKVTCLRVSQPYMMIAS 513
Query: 1841 LDTHGTTIVWDLKNGTVINK---FSIMAKLVAISPTTGSVSIAGEKGISIFDLNGSIYCL 1897
T I+WDL + + + + F + + I+ TG + A ++++ +NG +
Sbjct: 514 GSDDCTVIIWDLSSLSFVRQLPDFPVPISAIYINDLTGEIVTAAGTVLAVWSINGDCLAV 573
Query: 1898 HETAE 1902
T++
Sbjct: 574 ANTSQ 578
>7290560 [U] KOG1787 Kinase A-anchor protein Neurobeachin and related BEACH
and WD40 repeat proteins
Length = 3614
Score = 327 bits (838), Expect = 1e-88
Identities = 180/435 (41%), Positives = 257/435 (58%), Gaps = 40/435 (9%)
Query: 1337 WKVKTLNRTIKRPFLLRDTAMELFFGLKNTIMFSFKDQSIRDDVFSTLKKYAKDDKHDSI 1396
W + R +LL++ A+E+F + +I+F+F DQ T+KK K
Sbjct: 2874 WYFSEVRAIFSRRYLLQNVALEIFLASRTSILFAFPDQH-------TVKKVIK------- 2919
Query: 1397 WSSILEEVNFKSNVLSSKNGISRTSISDKVSAAFTSITKYHASEKILDLWQAGSLSNFDY 1456
L V + K GI +T A+ S + + + WQ +SNF+Y
Sbjct: 2920 ---ALPRVG-----VGIKYGIPQTR-----RASMMSPRQLMRNSNMTQKWQRREISNFEY 2966
Query: 1457 LMALNTLAGRTFNDLTQYPVFPWVIADYVSDSIDLENPKTYRDLSKPMGAQSEKRMMNFI 1516
LM LNT+AGRT+NDL QYP+FPWV+ +Y S +DL P YRDLSKP+GA + R F
Sbjct: 2967 LMFLNTIAGRTYNDLNQYPIFPWVLTNYESKDLDLSLPSNYRDLSKPIGALNPSRRAYFE 3026
Query: 1517 ERFQALKDLDDTSTPPFHYGTHYSSAMIVSSYLVRLQPFADTYKTLQGDQWGPPDRLFNS 1576
ER+++ D + PPFHYGTHYS+A ++LVR++PF + LQG ++ PDRLF+S
Sbjct: 3027 ERYESW---DSDTIPPFHYGTHYSTAAFTLNWLVRVEPFTTMFLALQGGKFDYPDRLFSS 3083
Query: 1577 VSRAWTSASSEASTDVRELIPEFYYLPDFLTNKNSYNFGTTQNGKEVTDVALPPWAKNDP 1636
VS +W + + S DV+ELIPE+Y+LP+ N + Y G ++G V D+ LPPWAK+ P
Sbjct: 3084 VSLSWKNCQRDTS-DVKELIPEWYFLPEMFYNSSGYRLGHREDGALVDDIELPPWAKS-P 3141
Query: 1637 KIFIEINRQALESRYVSEHLNEWIDLVFGFKQRGKEAIKAVNVFNSLSYSGNVDINGIDN 1696
+ F+ INR ALES +VS L++WIDL+FG+KQRG EAI+A NVF L+Y G+VD++G+ +
Sbjct: 3142 EEFVRINRMALESEFVSCQLHQWIDLIFGYKQRGPEAIRATNVFYYLTYEGSVDLDGVLD 3201
Query: 1697 DIERKAITGIIHNFGQTPLQIFQHPHPPRKCKAYL-----EVEDED---VRKFGDLKPSI 1748
+ R+A+ I NFGQTP Q+ PHPPR +L ED + KF P I
Sbjct: 3202 PVMREAVENQIRNFGQTPSQLLMEPHPPRSSAMHLSPMMFSAMPEDLCQMLKFYQNSPVI 3261
Query: 1749 NRTADKQSCICLPSI 1763
+ +A+ + LPS+
Sbjct: 3262 HISANTYPQLSLPSV 3276
>Hs22050699 [TU] KOG1786 Lysosomal trafficking regulator LYST and related BEACH
and WD40 repeat proteins
Length = 1606
Score = 323 bits (829), Expect = 1e-87
Identities = 168/380 (44%), Positives = 234/380 (61%), Gaps = 38/380 (10%)
Query: 1350 FLLRDTAMELFF--GLKNTIMFSFKDQSIRDDVFSTLKKYAKDDKHDSIWSSILEEVNFK 1407
FLL+D A+E+FF G ++F D+S F + +
Sbjct: 1158 FLLQDIALEIFFHNGYSKFLVFYNNDRSKAFKSFCSFQP--------------------- 1196
Query: 1408 SNVLSSKNGISRTSISDKVSAAFT-SITKYHASEKI-LDLWQAGSLSNFDYLMALNTLAG 1465
S+ K ++ T ++ +Y S++I L WQ +SNF+YLM LNT AG
Sbjct: 1197 -------------SLKGKATSEDTLNLRRYPGSDRIMLQKWQKRDISNFEYLMYLNTAAG 1243
Query: 1466 RTFNDLTQYPVFPWVIADYVSDSIDLENPKTYRDLSKPMGAQSEKRMMNFIERFQALKDL 1525
RT ND QYPVFPWV+ADY S++++L NPK +RDLSKPMGAQ+++R + FI+RF+ ++
Sbjct: 1244 RTCNDYMQYPVFPWVLADYTSETLNLANPKIFRDLSKPMGAQTKERKLKFIQRFKEVEKT 1303
Query: 1526 DDTSTPPFHYGTHYSSAMIVSSYLVRLQPFADTYKTLQGDQWGPPDRLFNSVSRAWTSAS 1585
+ T HY THYSSA+IV+SYLVR+ PF + LQG + DR+F+SV W SAS
Sbjct: 1304 EGDMTVQCHYYTHYSSAIIVASYLVRMPPFTQAFCALQGGSFDVADRMFHSVKSTWESAS 1363
Query: 1586 SEASTDVRELIPEFYYLPDFLTNKNSYNFGTTQNGKEVTDVALPPWAKNDPKIFIEINRQ 1645
E +DVREL PEF+YLP+FLTN N FG Q+G + DV LPPWA DP+ FI ++R+
Sbjct: 1364 RENMSDVRELTPEFFYLPEFLTNCNGVEFGCMQDGTVLGDVQLPPWADGDPRKFISLHRK 1423
Query: 1646 ALESRYVSEHLNEWIDLVFGFKQRGKEAIKAVNVFNSLSYSGNVDINGIDNDIERKAITG 1705
ALES +VS +L+ WIDL+FG+KQ+G A+ AVN+F+ Y +D++ I + + + I G
Sbjct: 1424 ALESDFVSANLHHWIDLIFGYKQQGPAAVDAVNIFHPYFYGDRMDLSSITDPLIKSTILG 1483
Query: 1706 IIHNFGQTPLQIFQHPHPPR 1725
+ NFGQ P Q+F PHP R
Sbjct: 1484 FVSNFGQVPKQLFTKPHPAR 1503
>Hs22051940 [U] KOG1787 Kinase A-anchor protein Neurobeachin and related BEACH
and WD40 repeat proteins
Length = 1017
Score = 322 bits (824), Expect = 5e-87
Identities = 179/470 (38%), Positives = 267/470 (56%), Gaps = 58/470 (12%)
Query: 1262 ASHIIGLLAKPGVLVLTTSSLYFISGCYYDSNEKKVLDLDALPEILRDLTIDSLSADLIT 1321
A I ++ G L +TT+ +YF E+ D DS + T
Sbjct: 229 AQLIAPVVVAKGTLSITTTEIYF--------------------EVDED---DSAFKKIDT 265
Query: 1322 KSIEADAEIESLRYGWKVKTLNRTIKRPFLLRDTAMELFFGLKNTIMFSFKDQSIRDDVF 1381
K + A E L W + R +LL++TA+E+F + ++MF+F DQ+ V
Sbjct: 266 KVL---AYTEGLHGKWMFSEIRAVFSRRYLLQNTALEVFMANRTSVMFNFPDQATVKKVV 322
Query: 1382 STLKKYAKDDKHDSIWSSILEEVNFKSNVLSSKNGISRTSISDKVSAAFTSITKYHASEK 1441
+L + + + G+ + ++S A + + + S
Sbjct: 323 YSLPRVG----------------------VGTSYGLPQAR---RISLA--TPRQLYKSSN 355
Query: 1442 ILDLWQAGSLSNFDYLMALNTLAGRTFNDLTQYPVFPWVIADYVSDSIDLENPKTYRDLS 1501
+ WQ +SNF+YLM LNT+AGRT+NDL QYPVFPWV+ +Y S+ +DL P +RDLS
Sbjct: 356 MTQRWQRREISNFEYLMFLNTIAGRTYNDLNQYPVFPWVLTNYESEELDLTLPGNFRDLS 415
Query: 1502 KPMGAQSEKRMMNFIERFQALKDLDDTSTPPFHYGTHYSSAMIVSSYLVRLQPFADTYKT 1561
KP+GA + KR + + ER++ +D +PP+HY THYS+A S+LVR++PF +
Sbjct: 416 KPIGALNPKRAVFYAERYETW---EDDQSPPYHYNTHYSTATSTLSWLVRIEPFTTFFLN 472
Query: 1562 LQGDQWGPPDRLFNSVSRAWTSASSEASTDVRELIPEFYYLPDFLTNKNSYNFGTTQNGK 1621
++ PDR F+SV+R+W ++ + S DV+ELIPEFYYLP+ N N YN G ++
Sbjct: 473 ANDGKFDHPDRTFSSVARSWRTSQRDTS-DVKELIPEFYYLPEMFVNSNGYNLGVREDEV 531
Query: 1622 EVTDVALPPWAKNDPKIFIEINRQALESRYVSEHLNEWIDLVFGFKQRGKEAIKAVNVFN 1681
V DV LPPWAK P+ F+ INR ALES +VS L++WIDL+FG+KQRG EA++A+NVF+
Sbjct: 532 VVNDVDLPPWAKK-PEDFVRINRMALESEFVSCQLHQWIDLIFGYKQRGPEAVRALNVFH 590
Query: 1682 SLSYSGNVDINGIDNDIERKAITGIIHNFGQTPLQIFQHPHPPRKCKAYL 1731
L+Y G+V+++ I + + R+A+ I NFGQTP Q+ PHPPR +L
Sbjct: 591 YLTYEGSVNLDSITDPVLREAMEAQIQNFGQTPSQLLIEPHPPRSSAMHL 640
>Hs21536252 [U] KOG1787 Kinase A-anchor protein Neurobeachin and related BEACH
and WD40 repeat proteins
Length = 2946
Score = 322 bits (824), Expect = 5e-87
Identities = 179/470 (38%), Positives = 267/470 (56%), Gaps = 58/470 (12%)
Query: 1262 ASHIIGLLAKPGVLVLTTSSLYFISGCYYDSNEKKVLDLDALPEILRDLTIDSLSADLIT 1321
A I ++ G L +TT+ +YF E+ D DS + T
Sbjct: 2158 AQLIAPVVVAKGTLSITTTEIYF--------------------EVDED---DSAFKKIDT 2194
Query: 1322 KSIEADAEIESLRYGWKVKTLNRTIKRPFLLRDTAMELFFGLKNTIMFSFKDQSIRDDVF 1381
K + A E L W + R +LL++TA+E+F + ++MF+F DQ+ V
Sbjct: 2195 KVL---AYTEGLHGKWMFSEIRAVFSRRYLLQNTALEVFMANRTSVMFNFPDQATVKKVV 2251
Query: 1382 STLKKYAKDDKHDSIWSSILEEVNFKSNVLSSKNGISRTSISDKVSAAFTSITKYHASEK 1441
+L + + + G+ + ++S A + + + S
Sbjct: 2252 YSLPRVG----------------------VGTSYGLPQAR---RISLA--TPRQLYKSSN 2284
Query: 1442 ILDLWQAGSLSNFDYLMALNTLAGRTFNDLTQYPVFPWVIADYVSDSIDLENPKTYRDLS 1501
+ WQ +SNF+YLM LNT+AGRT+NDL QYPVFPWV+ +Y S+ +DL P +RDLS
Sbjct: 2285 MTQRWQRREISNFEYLMFLNTIAGRTYNDLNQYPVFPWVLTNYESEELDLTLPGNFRDLS 2344
Query: 1502 KPMGAQSEKRMMNFIERFQALKDLDDTSTPPFHYGTHYSSAMIVSSYLVRLQPFADTYKT 1561
KP+GA + KR + + ER++ +D +PP+HY THYS+A S+LVR++PF +
Sbjct: 2345 KPIGALNPKRAVFYAERYETW---EDDQSPPYHYNTHYSTATSTLSWLVRIEPFTTFFLN 2401
Query: 1562 LQGDQWGPPDRLFNSVSRAWTSASSEASTDVRELIPEFYYLPDFLTNKNSYNFGTTQNGK 1621
++ PDR F+SV+R+W ++ + S DV+ELIPEFYYLP+ N N YN G ++
Sbjct: 2402 ANDGKFDHPDRTFSSVARSWRTSQRDTS-DVKELIPEFYYLPEMFVNSNGYNLGVREDEV 2460
Query: 1622 EVTDVALPPWAKNDPKIFIEINRQALESRYVSEHLNEWIDLVFGFKQRGKEAIKAVNVFN 1681
V DV LPPWAK P+ F+ INR ALES +VS L++WIDL+FG+KQRG EA++A+NVF+
Sbjct: 2461 VVNDVDLPPWAKK-PEDFVRINRMALESEFVSCQLHQWIDLIFGYKQRGPEAVRALNVFH 2519
Query: 1682 SLSYSGNVDINGIDNDIERKAITGIIHNFGQTPLQIFQHPHPPRKCKAYL 1731
L+Y G+V+++ I + + R+A+ I NFGQTP Q+ PHPPR +L
Sbjct: 2520 YLTYEGSVNLDSITDPVLREAMEAQIQNFGQTPSQLLIEPHPPRSSAMHL 2569
>Hs16904381 [U] KOG1787 Kinase A-anchor protein Neurobeachin and related BEACH
and WD40 repeat proteins
Length = 2863
Score = 320 bits (821), Expect = 1e-86
Identities = 183/454 (40%), Positives = 263/454 (57%), Gaps = 60/454 (13%)
Query: 1273 GVLVLTTSSLYFISGCYYDSNEKKVLDLDALPEILRDLTIDSLSADLITKSIEADAEIES 1332
G L +T+S LYF D + +D P+IL A E
Sbjct: 2095 GTLSVTSSELYF----EVDEEDPNFKKID--PKIL--------------------AYTEG 2128
Query: 1333 LRYGWKVKTLNRTIKRPFLLRDTAMELFFGLKNTIMFSFKDQSIRDDVFSTLKKYAKDDK 1392
L W + R +LL++TA+E+F + +MF+F D + T+KK
Sbjct: 2129 LHGKWLFTEIRSIFSRRYLLQNTALEIFMANRVAVMFNFPDPA-------TVKKV----- 2176
Query: 1393 HDSIWSSILEEVNFKSNV-LSSKNGISRTSISDKVSAAFTSITKYHASEKILDLWQAGSL 1451
VNF V + + G+ +T ++S A S + + + WQ +
Sbjct: 2177 -----------VNFLPRVGVGTSFGLPQTR---RISLA--SPRQLFKASNMTQRWQHREI 2220
Query: 1452 SNFDYLMALNTLAGRTFNDLTQYPVFPWVIADYVSDSIDLENPKTYRDLSKPMGAQSEKR 1511
SNF+YLM LNT+AGR++NDL QYPVFPWVI +Y S+ +DL P +RDLSKP+GA + KR
Sbjct: 2221 SNFEYLMFLNTIAGRSYNDLNQYPVFPWVITNYESEELDLTLPTNFRDLSKPIGALNPKR 2280
Query: 1512 MMNFIERFQALKDLDDTSTPPFHYGTHYSSAMIVSSYLVRLQPFADTYKTLQGDQWGPPD 1571
F ER+++ +D P FHYGTHYS+A V ++L+R++PF + LQG ++ D
Sbjct: 2281 AAFFAERYESW---EDDQVPKFHYGTHYSTASFVLAWLLRIEPFTTYFLNLQGGKFDHAD 2337
Query: 1572 RLFNSVSRAWTSASSEASTDVRELIPEFYYLPDFLTNKNSYNFGTTQNGKEVTDVALPPW 1631
R F+S+SRAW ++ + S D++ELIPEFYYLP+ N N+YN G +G V+DV LPPW
Sbjct: 2338 RTFSSISRAWRNSQRDTS-DIKELIPEFYYLPEMFVNFNNYNLGVMDDGTVVSDVELPPW 2396
Query: 1632 AKNDPKIFIEINRQALESRYVSEHLNEWIDLVFGFKQRGKEAIKAVNVFNSLSYSGNVDI 1691
AK + F+ INR ALES +VS L++WIDL+FG+KQ+G EA++A+NVF L+Y G V++
Sbjct: 2397 AKTSEE-FVHINRLALESEFVSCQLHQWIDLIFGYKQQGPEAVRALNVFYYLTYEGAVNL 2455
Query: 1692 NGIDNDIERKAITGIIHNFGQTPLQIFQHPHPPR 1725
N I + + R+A+ I +FGQTP Q+ PHPPR
Sbjct: 2456 NSITDPVLREAVEAQIRSFGQTPSQLLIEPHPPR 2489
>Hs22042385 [U] KOG1787 Kinase A-anchor protein Neurobeachin and related BEACH
and WD40 repeat proteins
Length = 2040
Score = 310 bits (793), Expect = 2e-83
Identities = 204/575 (35%), Positives = 304/575 (52%), Gaps = 57/575 (9%)
Query: 1160 LRDFKSTREWYLAARENVKRQRIQLLPV--FEPIDFLPSLKLKLQDIH---KHRAALPHS 1214
LRD R W L++ E R R++L+P F+P +L+ L ++ A+LP +
Sbjct: 1105 LRDTPIPR-WKLSSAETYSRMRLKLVPNHHFDPHLEASALRDNLGEVPLTPTEEASLPLA 1163
Query: 1215 DTASTIISTQDLNVDVESEGSDQFA-LDKNRAVLQLLRKDERILNIWNASHIIGLLAKPG 1273
T +ST + + G D+ A L+ +L + E+++ + + PG
Sbjct: 1164 VTKEAKVSTPPELLQEDQLGEDELAELETPMEAAELDEQREKLVLSAECQLVTVVAVVPG 1223
Query: 1274 VLVLTTSSLYFISGCYYDSNEKKVLDLDALPEILRDLTIDSLSADLITKSIEADAEIESL 1333
+L +TT ++YF G T+ +E + E +
Sbjct: 1224 LLEVTTQNVYFYDGS--------------------------------TERVETE---EGI 1248
Query: 1334 RYGWK--VKTLNRTIKRPFLLRDTAMELFFGLKNTIMFSFKDQSIRDDVFSTLKKYAKDD 1391
Y ++ + L R F LR +A+ELFF + +F + V S +
Sbjct: 1249 GYDFRRPLAQLREVHLRRFNLRRSALELFFIDQANYFLNFPCKVGTTPVSSPSQTPRPQP 1308
Query: 1392 KHDSIWSSILEEVNFKSNVLSSKNGISRTSISDKVSAAFTSITKYHASEKILDLWQAGSL 1451
I ++ V S + R + + S + + + W +
Sbjct: 1309 ------GPIPPHTQVRNQVYS---WLLRLRPPSQGYLSSRSPQEMLRASGLTQKWVQREI 1359
Query: 1452 SNFDYLMALNTLAGRTFNDLTQYPVFPWVIADYVSDSIDLENPKTYRDLSKPMGAQSEKR 1511
SNF+YLM LNT+AGRT+NDL+QYPVFPWV+ DYVS ++DL NP +RDLSKP+G + K
Sbjct: 1360 SNFEYLMQLNTIAGRTYNDLSQYPVFPWVLQDYVSPTLDLSNPAVFRDLSKPIGVVNPKH 1419
Query: 1512 MMNFIERFQALKDLDDTSTPPFHYGTHYSSAMIVSSYLVRLQPFADTYKTLQGDQWGPPD 1571
E++++ +D T FHYGTHYS+A V YL+R++PF + LQ ++ D
Sbjct: 1420 AQLVREKYESFEDPAGT-IDKFHYGTHYSNAAGVMHYLIRVEPFTSLHVQLQSGRFDCSD 1478
Query: 1572 RLFNSVSRAWTSASSEASTDVRELIPEFYYLPDFLTNKNSYNFGTTQ-NGKEVTDVALPP 1630
R F+SV+ AW A E+ DV+ELIPEF+Y PDFL N+N ++ G Q ++V DV LPP
Sbjct: 1479 RQFHSVAAAW-QARLESPADVKELIPEFFYFPDFLENQNGFDLGCLQLTNEKVGDVVLPP 1537
Query: 1631 WAKNDPKIFIEINRQALESRYVSEHLNEWIDLVFGFKQRGKEAIKAVNVFNSLSYSGNVD 1690
WA + P+ FI+ +RQALES YVS HL+EWIDL+FG+KQRG A +A+NVF +Y G VD
Sbjct: 1538 WASS-PEDFIQQHRQALESEYVSAHLHEWIDLIFGYKQRGPAAEEALNVFYYCTYEGAVD 1596
Query: 1691 INGIDNDIERKAITGIIHNFGQTPLQIFQHPHPPR 1725
++ + ++ ERKA+ GII NFGQTP Q+ + PHP R
Sbjct: 1597 LDHVTDERERKALEGIISNFGQTPCQLLKEPHPTR 1631
>Hs4502839 [TU] KOG1786 Lysosomal trafficking regulator LYST and related BEACH
and WD40 repeat proteins
Length = 3801
Score = 307 bits (787), Expect = 1e-82
Identities = 158/424 (37%), Positives = 252/424 (59%), Gaps = 52/424 (12%)
Query: 1322 KSIEADAEIESLRYGWKVKTLNRTIKRPFLLRDTAMELFFGLKNTIMFSFKDQSIRDDVF 1381
+S E+E + W + + KR + LRD A+E+F T++ +F + +RDDV+
Sbjct: 3052 ESSSLQGELEPASFSWTYEEIKEVHKRWWQLRDNAVEIFLTNGRTLLLAFDNTKVRDDVY 3111
Query: 1382 STLKKYAKDDKHDSIWSSILEEVNFKSNVLSSKNGISRTSISDKVSAAFTSITKYHASEK 1441
N+L++ ++ +Y
Sbjct: 3112 H--------------------------NILTNN---------------LPNLLEYGNITA 3130
Query: 1442 ILDLWQAGSLSNFDYLMALNTLAGRTFNDLTQYPVFPWVIADYVSDSIDLENPKTYRDLS 1501
+ +LW G ++NF+YL LN AGR+FNDL QYPVFP+++ADYVS+++DL + YR+LS
Sbjct: 3131 LTNLWYTGQITNFEYLTHLNKHAGRSFNDLMQYPVFPFILADYVSETLDLNDLLIYRNLS 3190
Query: 1502 KPMGAQSEKRMMNFIERFQALKDL-------DDTSTP--PFHYGTHYSSAMIVSSYLVRL 1552
KP+ Q +++ +++ ++ L++ DD P P+HYG+HYS++ V +LVR+
Sbjct: 3191 KPIAVQYKEKEDRYVDTYKYLEEEYRKGAREDDPMPPVQPYHYGSHYSNSGTVLHFLVRM 3250
Query: 1553 QPFADTYKTLQGDQWGPPDRLFNSVSRAWTSASSEASTDVRELIPEFYYLPDFLTNKNSY 1612
PF + Q + PDR F+S + W +S E+ TDV+ELIPEF+YLP+FL N+ +
Sbjct: 3251 PPFTKMFLAYQDQSFDIPDRTFHSTNTTWRLSSFESMTDVKELIPEFFYLPEFLVNREGF 3310
Query: 1613 NFGTTQNGKEVTDVALPPWAKNDPKIFIEINRQALESRYVSEHLNEWIDLVFGFKQRGKE 1672
+FG QNG+ V V LPPWA+NDP++FI I+RQALES YVS+++ +WIDLVFG+KQ+GK
Sbjct: 3311 DFGVRQNGERVNHVNLPPWARNDPRLFILIHRQALESDYVSQNICQWIDLVFGYKQKGKA 3370
Query: 1673 AIKAVNVFNSLSYSGNVDINGIDNDIERKAITGIIHNFGQTPLQIFQHPHPPRKCKAYLE 1732
+++A+NVF+ +Y G +D++ +++ ++R+A+ +I +GQTP Q+F H R A L
Sbjct: 3371 SVQAINVFHPATYFG-MDVSAVEDPVQRRALETMIKTYGQTPRQLFHMAHVSRP-GAKLN 3428
Query: 1733 VEDE 1736
+E E
Sbjct: 3429 IEGE 3432
>At2g45540 [U] KOG1787 Kinase A-anchor protein Neurobeachin and related BEACH
and WD40 repeat proteins
Length = 2946
Score = 301 bits (772), Expect = 5e-81
Identities = 180/473 (38%), Positives = 258/473 (54%), Gaps = 61/473 (12%)
Query: 1253 DERILNIWNASHIIGLLAKPGVLVLTTSSLYFISGCYYDSNEKKVLDLDALPEILRDLTI 1312
DERIL S + L G +TT + FI D+ E + L
Sbjct: 2098 DERILLELPTSMVRPLRVVKGTFQITTRRINFI----VDNRESQNL-------------- 2139
Query: 1313 DSLSADLITKSIEADAEIESLRYGWKVKTLNRTIKRPFLLRDTAMELFFGLKNTIMFSFK 1372
AD +S D E + W + +L++ R +LLR +A+ELF ++ F F
Sbjct: 2140 ----ADHSDESQSGDQEKDR---SWPMSSLHQIYSRRYLLRRSALELFMVDRSNFFFDFG 2192
Query: 1373 DQSIRDDVFSTLKKYAKDDKHDSIWSSILEEVNFKSNVLSSKNGISRTSISDKVSAAFTS 1432
+ R + + + + +R + + A
Sbjct: 2193 NTEGRRNAYRAIVQ-------------------------------ARPPHLNNIYLATQR 2221
Query: 1433 ITKYHASEKILDLWQAGSLSNFDYLMALNTLAGRTFNDLTQYPVFPWVIADYVSDSIDLE 1492
+ ++++ W +SNF+YLM LNTLAGR++ND+TQYPVFPW+I+D S+S+DL
Sbjct: 2222 PEQLLRRTQLMERWARWEISNFEYLMQLNTLAGRSYNDITQYPVFPWIISDNSSESLDLS 2281
Query: 1493 NPKTYRDLSKPMGAQSEKRMMNFIERFQALKDLDDTSTPPFHYGTHYSSAMIVSSYLVRL 1552
NP T+RDLSKP+GA + +R+ F ER+ + +D P FHYG+HYSSA V YL R+
Sbjct: 2282 NPSTFRDLSKPIGALNPERLKKFQERYSS---FEDPVIPKFHYGSHYSSAGAVLYYLARV 2338
Query: 1553 QPFADTYKTLQGDQWGPPDRLFNSVSRAWTSASSEASTDVRELIPEFYYLPDFLTNKNSY 1612
+PF LQG ++ DR+F+ W + S DV+EL+PE +YLP+ LTN+NS
Sbjct: 2339 EPFTTLSIQLQGGKFDHADRMFSDFPGTWNGVLEDMS-DVKELVPELFYLPEVLTNENSI 2397
Query: 1613 NFGTTQNGKEVTDVALPPWAKNDPKIFIEINRQALESRYVSEHLNEWIDLVFGFKQRGKE 1672
+FGTTQ G+++ V LPPWAKN P F+ R+ALES +VS HL+EWIDL+FG+KQRGKE
Sbjct: 2398 DFGTTQLGEKLDAVKLPPWAKN-PVDFVHKQRRALESEHVSAHLHEWIDLIFGYKQRGKE 2456
Query: 1673 AIKAVNVFNSLSYSGNVDINGIDNDIERKAITGIIHNFGQTPLQIFQHPHPPR 1725
AI A NVF ++Y G VDI+ I + ++++A I FGQTP Q+ PH R
Sbjct: 2457 AIMANNVFFYITYEGTVDIDKITDPVQQRATQDQIAYFGQTPSQLLTVPHMKR 2509
>CE00946 [U] KOG1787 Kinase A-anchor protein Neurobeachin and related BEACH
and WD40 repeat proteins
Length = 2528
Score = 290 bits (742), Expect = 2e-77
Identities = 173/497 (34%), Positives = 257/497 (50%), Gaps = 71/497 (14%)
Query: 1272 PGVLVLTTSSLYFISGCYYDSNEKKVLDLDALPEILRDLTIDSLSADLITKSIEADAEIE 1331
PG L +T + L+F D+NE ++LR E
Sbjct: 1732 PGTLSVTANDLFF------DANESDPNYKKQCAQVLR--------------------YCE 1765
Query: 1332 SLRYGWKVKTLNRTIKRPFLLRDTAMELFFGLKNTIMFSFKDQSIRDDVFSTLKKYAKDD 1391
+L W ++ + R +LL++TA+ELF + IMF+F + V L +
Sbjct: 1766 ALHARWNLQEIRAIFLRRYLLQNTALELFLASRTAIMFAFDSEDAVKKVVYQLPRVGVGV 1825
Query: 1392 KHDSIWSSILEEVNFKSNVLSSKNGISRTSISDKVSAAFTSITKYHASEKILDLWQAGSL 1451
K+ S K+++++ + + + K WQ +
Sbjct: 1826 KYGLPQSR-------KTSLMTPRQLFKHSDMCAK--------------------WQKREI 1858
Query: 1452 SNFDYLMALNTLAGRTFNDLTQYPVFPWVIADYVSDSIDLENPKTYRDLSKPMGAQSEKR 1511
SNFDYLM LNT+AGRTFNDL+QYPVFPW++ +Y SD++DL +RDLSKP+GA SE R
Sbjct: 1859 SNFDYLMFLNTVAGRTFNDLSQYPVFPWILTNYTSDTLDLSVASNFRDLSKPIGALSEAR 1918
Query: 1512 MMNFIERFQALKDLDDTSTPPFHYGTHYSSAMIVSSYLVRLQPFADTYKTLQGDQWGPPD 1571
F +R+ + DD P FHYGTHYS+ ++L+R++PFA + L ++ PD
Sbjct: 1919 RKFFNDRYTS---WDDDQVPAFHYGTHYSTPAFTLNWLLRVEPFASMFINLHDGKFDHPD 1975
Query: 1572 RLFNSVSRAWTSASSEASTDVRELIPEFYYLPDFLTNKNSYNFGTTQNGKEVTDVALPPW 1631
R+ +S+ +W + S DV+ELIPE +YLP+ N + +N G +G V DV LPPW
Sbjct: 1976 RITHSIKDSWDRCQRD-SHDVKELIPELFYLPEMFRNSSKFNLGRRADGTPVDDVVLPPW 2034
Query: 1632 AKNDPKIFIEINRQALESRYVSEHLNEWIDLVFGFKQRGKEAIKAVNVFNSLSYSGNVDI 1691
A++ P+ F+ ++RQALES VS LN+WIDL+FG+KQRG EA++A NVF L+Y G V
Sbjct: 2035 AES-PEHFVLMHRQALESDLVSCQLNQWIDLIFGYKQRGAEAVRATNVFYHLTYEGTVTP 2093
Query: 1692 NGIDNDIERKAITGIIHNFGQTPLQIFQHPHPPRKCKAYLEVEDEDVRKFGDLKPSINRT 1751
+ + AI I +FGQTP Q+ HPPR + P++ R
Sbjct: 2094 KMAETPGQVAAIEQQILSFGQTPSQLLTEAHPPR-------------HSIMSMAPTMFRR 2140
Query: 1752 ADKQSCICLPSISHRDI 1768
D+ C+ + IS+ +
Sbjct: 2141 HDEDLCMMMKYISNSPV 2157
>At1g58240 [U] KOG1787 Kinase A-anchor protein Neurobeachin and related BEACH
and WD40 repeat proteins
Length = 1071
Score = 284 bits (727), Expect = 9e-76
Identities = 135/265 (50%), Positives = 187/265 (69%), Gaps = 4/265 (1%)
Query: 1461 NTLAGRTFNDLTQYPVFPWVIADYVSDSIDLENPKTYRDLSKPMGAQSEKRMMNFIERFQ 1520
+T GR++NDLTQYPVFPWV+ADY S+++D T+RDLSKP+GA +R F +R+
Sbjct: 462 STSKGRSYNDLTQYPVFPWVVADYSSETLDFSKASTFRDLSKPVGALDTRRFEIFEDRYH 521
Query: 1521 ALKDLDDTSTPPFHYGTHYSSAMIVSSYLVRLQPFADTYKTLQGDQWGPPDRLFNSVSRA 1580
+ D D P F+YG+HYSS V YL+RL+PF +++LQG ++ DRLF SV +
Sbjct: 522 SFSDPD---IPSFYYGSHYSSMGSVLYYLLRLEPFTSLHRSLQGGKFDHADRLFQSVEGS 578
Query: 1581 WTSASSEASTDVRELIPEFYYLPDFLTNKNSYNFGTTQNGKEVTDVALPPWAKNDPKIFI 1640
+ + S S DV+ELIPEF+Y+P+FL N NSY+ G Q+G+ + +V LPPWAK P++FI
Sbjct: 579 FRNCLSNTS-DVKELIPEFFYMPEFLVNSNSYHLGVKQDGEPLGEVCLPPWAKGSPEMFI 637
Query: 1641 EINRQALESRYVSEHLNEWIDLVFGFKQRGKEAIKAVNVFNSLSYSGNVDINGIDNDIER 1700
NR+ALES YVS HL++WIDL+FG KQRGK A++A N+F L+Y G VD+ +++ ++
Sbjct: 638 ARNREALESEYVSSHLHDWIDLIFGHKQRGKPAVEAANIFYYLTYEGAVDVENMEDQLQI 697
Query: 1701 KAITGIIHNFGQTPLQIFQHPHPPR 1725
AI I NFGQTP+QIF+ HP R
Sbjct: 698 SAIEDQIANFGQTPIQIFRKKHPRR 722
>Hs4505465_2 [TU] KOG1786 Lysosomal trafficking regulator LYST and related BEACH
and WD40 repeat proteins
Length = 631
Score = 266 bits (681), Expect = 2e-70
Identities = 138/290 (47%), Positives = 189/290 (64%), Gaps = 11/290 (3%)
Query: 1437 HASEKILDLWQAGSLSNFDYLMALNTLAGRTFNDLTQYPVFPWVIADYVSDSIDLENPKT 1496
H +E + WQ G LSN+ YL+ LN LA R+ NDL+QYPVFPW+I DY S +DL NP T
Sbjct: 10 HTAESYMLQWQRGHLSNYQYLLHLNNLADRSCNDLSQYPVFPWIIHDYSSSELDLSNPGT 69
Query: 1497 YRDLSKPMGAQSEKRMMNFIERFQALKDLDDTSTPPFHYGTHYSSAMIVSSYLVRLQPFA 1556
+RDLSKP+GA +++R+ + R+Q + + P F YG+HYSS V YLVR+ P
Sbjct: 70 FRDLSKPVGALNKERLERLLTRYQEMPE------PKFMYGSHYSSPGYVLFYLVRIAP-- 121
Query: 1557 DTYKTLQGDQWGPPDRLFNSVSRAWTSASSEASTDVRELIPEFYYLP-DFLTNKNSYNFG 1615
+ LQ ++ DR+FNS++ W + + +TD +ELIPEFY FL N + G
Sbjct: 122 EYMLCLQNGRFDNADRMFNSIAETWKNCL-DGATDFKELIPEFYGDDVSFLVNSLKLDLG 180
Query: 1616 TTQNGKEVTDVALPPWAKNDPKIFIEINRQALESRYVSEHLNEWIDLVFGFKQRGKEAIK 1675
Q G+ V DV LPPWA + P+ F++ ++ ALES YVSEHL+EWIDL+FG+KQ+G +A+
Sbjct: 181 KRQGGQMVDDVELPPWASS-PEDFLQKSKDALESNYVSEHLHEWIDLIFGYKQKGSDAVG 239
Query: 1676 AVNVFNSLSYSGNVDINGIDNDIERKAITGIIHNFGQTPLQIFQHPHPPR 1725
A NVF+ L+Y G VD+N I + E+ A+ I FGQTP Q+F PHP R
Sbjct: 240 AHNVFHPLTYEGGVDLNSIQDPDEKVAMLTQILEFGQTPKQLFVTPHPRR 289
>7292187 [TU] KOG1786 Lysosomal trafficking regulator LYST and related BEACH
and WD40 repeat proteins
Length = 2517
Score = 261 bits (667), Expect = 8e-69
Identities = 137/360 (38%), Positives = 216/360 (59%), Gaps = 14/360 (3%)
Query: 1375 SIRDDVFSTLKKYAKDDKHDSIWSSILEEVNFKSNVLSSKNG----ISRTSISDKVSAAF 1430
++ D+ + + + K +H IL + N KS S +N I R DK+ A
Sbjct: 1711 NVNCDIANITEIWLKRYQHQETAFEILLDTN-KSLFFSLQNADDWKIMREVFCDKIVAT- 1768
Query: 1431 TSITKYHASEKILDLWQAGSLSNFDYLMALNTLAGRTFNDLTQYPVFPWVIADYVSDSID 1490
+K A I W+ G L+N++YLM LN ++GRT+NDL QYPVFPWV+A+Y S+ +D
Sbjct: 1769 PDQSKVIA---ITQQWREGLLTNWEYLMTLNQISGRTYNDLMQYPVFPWVLANYNSEVLD 1825
Query: 1491 LENPKTYRDLSKPMGAQSEKRMMNFIERFQALKDLDDTS----TPPFHYGTHYSSAMIVS 1546
L +R L +P+ Q E+ ++I + + + T P+HY +HYS++ V
Sbjct: 1826 LREGHNFRRLGRPIAVQVEENEKHYISNYTYIDSTNTTMGSLILKPYHYSSHYSNSGTVL 1885
Query: 1547 SYLVRLQPFADTYKTLQGDQWGPPDRLFNSVSRAWTSASSEASTDVRELIPEFYYLPDFL 1606
+LVR+ PF + Q + + PDR F++++ W AS ++ TDV+ELIPEF+ LP+
Sbjct: 1886 HFLVRVPPFTSYFLRYQDNDFDLPDRTFHALNTTWLLASRDSPTDVKELIPEFFCLPEMF 1945
Query: 1607 TNKNSYNFGTTQNGKEVTDVALPPWAKNDPKIFIEINRQALESRYVSEHLNEWIDLVFGF 1666
N + FG QNG+ V DV+LPPW++ D ++F+ I+RQALES V ++ WIDL+FG+
Sbjct: 1946 ENFERFKFGCRQNGERVEDVSLPPWSQRDSRLFVLIHRQALESELVRNQIHNWIDLIFGY 2005
Query: 1667 KQRGKEAIKAVNVFNSLSYSGNVDINGIDNDIERKAITGIIHNFGQTPLQIFQHPHPPRK 1726
KQ G+ A++A+NVF+ +Y+ +D + I + IER+A+ ++ +GQ P Q+F+ PHP K
Sbjct: 2006 KQSGESAVEAINVFHPATYAVFLD-SEISDPIEREAVKTMVKTYGQMPRQLFKSPHPASK 2064
>7292461 [TU] KOG1786 Lysosomal trafficking regulator LYST and related BEACH
and WD40 repeat proteins
Length = 511
Score = 255 bits (652), Expect = 4e-67
Identities = 126/259 (48%), Positives = 178/259 (68%), Gaps = 4/259 (1%)
Query: 1446 WQAGSLSNFDYLMALNTLAGRTFNDLTQYPVFPWVIADYVSDSIDLENPKTYRDLSKPMG 1505
W +SNF+YLM LNT+AGR++NDL+QYPVFPW++ADY SD +DL +PK++RDLSKP+G
Sbjct: 198 WINREISNFEYLMYLNTIAGRSYNDLSQYPVFPWILADYTSDVLDLTDPKSFRDLSKPIG 257
Query: 1506 AQSEKRMMNFIERFQALKDLDDTSTPPFHYGTHYSSAMIVSSYLVRLQPFADTYKTLQGD 1565
+ K ++ + +D + P FHYGTHYS++ V YL+R++PF + LQ
Sbjct: 258 CINPKNEAEVRGKYDSFED-PSGAIPKFHYGTHYSNSAGVLHYLLRVEPFTSLHIDLQSG 316
Query: 1566 QWGPPDRLFNSVSRAWTSASSEASTDVRELIPEFYYLPDFLTNKNSYNFGTTQNGKE-VT 1624
++ DR F+S+ + W + DV+ELIPEF+Y P+FL N N ++ G Q KE V
Sbjct: 317 RFDVADRQFHSIPQTWKLLMDNPN-DVKELIPEFFYFPEFLKNMNKFDLGHLQITKEKVD 375
Query: 1625 DVALPPWAKNDPKIFIEINRQALESRYVSEHLNEWIDLVFGFKQRGKEAIKAVNVFNSLS 1684
DV LP WA P+ FI I+R+ALES YVS+HL+ WIDL+FG+KQ+G +A +A+NVF S
Sbjct: 376 DVILPAWATT-PEEFIAIHRRALESEYVSQHLHHWIDLIFGYKQKGPKAAEALNVFYYCS 434
Query: 1685 YSGNVDINGIDNDIERKAI 1703
Y G VD++ I N +ER+A+
Sbjct: 435 YEGAVDLDKITNPVEREAV 453
>CE03607 [TU] KOG1786 Lysosomal trafficking regulator LYST and related BEACH
and WD40 repeat proteins
Length = 2692
Score = 197 bits (501), Expect = 1e-49
Identities = 106/286 (37%), Positives = 156/286 (54%), Gaps = 6/286 (2%)
Query: 1446 WQAGSLSNFDYLMALNTLAGRTFNDLTQYPVFPWVIADYVSDSIDLENPKTYRDLSKPMG 1505
W+ G +SNF+YL LN AGRT +D + P+FP ++A + S+DL++ YR L +P+
Sbjct: 2022 WEEGKMSNFEYLTMLNLFAGRTIHDSSSSPIFPRILAKFGDKSVDLQDKTIYRKLDRPVA 2081
Query: 1506 AQSEKRMMNFIERFQALKDLDDTS-TPPFHYGTHYSSAMIVSSYLVRLQPFADTYKTLQG 1564
AQ + E + LK+ ++ S P+H+G+ S+ +VS + +RL PF + LQ
Sbjct: 2082 AQDPVSVEKHKEHYNELKENEEISHLTPYHFGSMCSNRGVVSFFNIRLLPFGEEAIELQD 2141
Query: 1565 DQWGPPDRLFNSVSRAWTSASSEASTDVRELIPEFYYLPDFLTNKNSYNFGTTQNGKEVT 1624
++ PDRLF+++ E+S D +EL+PE + + L N N FG QNG+ V
Sbjct: 2142 GRFDFPDRLFHNIESGLGLGKIESSNDYKELVPELFTTVEVLRNDNGNQFGEKQNGETVN 2201
Query: 1625 DVALPPWAKNDPKI----FIEINRQALESRYVSEHLNEWIDLVFGFKQRGKEAIKAVNVF 1680
DV +P W D K FI ++R ALES V L+ WIDLVFG+K RGK A A+NV+
Sbjct: 2202 DVDVPQWCYMDEKAVHENFIYLHRHALESEIVQSMLHHWIDLVFGYKSRGKSAHDAINVY 2261
Query: 1681 NSLSYSGNVDINGIDNDIERKAITGIIHNFGQTPLQIFQHPHPPRK 1726
+ Y GN D + A G P+Q+F HP R+
Sbjct: 2262 HPAVYPGNSPPPSFDR-VMTNAYEANQKTLGTAPIQLFTQSHPKRE 2306
>At3g60920 [U] KOG1787 Kinase A-anchor protein Neurobeachin and related BEACH
and WD40 repeat proteins
Length = 1857
Score = 146 bits (369), Expect = 3e-34
Identities = 69/156 (44%), Positives = 104/156 (66%), Gaps = 5/156 (3%)
Query: 1441 KILDLWQAGSLSNFDYLMALNTLAGRTFNDLTQYPVFPWVIADYVSDSIDLENPKTYRDL 1500
++++ W +SNF+YLM LNTLAGR++ND+TQYP+FPW++ DYVS+ +DL NP YRDL
Sbjct: 1593 QLMERWARWEISNFEYLMQLNTLAGRSYNDITQYPIFPWILCDYVSEILDLSNPSNYRDL 1652
Query: 1501 SK-PMGAQSEKRMMNFIERFQALKDLDDTSTPPFHYGTHYSSAMIVSSYLVRLQPFADTY 1559
SK P+GA + +R+ F E+ + +D P FHYG+HYSSA V YL R++PF
Sbjct: 1653 SKVPIGALNPERLKKFQEKHSS---FEDPVIPKFHYGSHYSSAGAVLHYLARVEPFTTLS 1709
Query: 1560 KTLQGDQWGPPDRLFNSVSRAWTSASSEASTDVREL 1595
LQG ++ D++F+ ++ W + + +V+EL
Sbjct: 1710 IQLQGRKFDRADQIFSDIAATWKGVLQDMN-NVKEL 1744
>HsM7657363 [U] KOG1787 Kinase A-anchor protein Neurobeachin and related BEACH
and WD40 repeat proteins
Length = 524
Score = 123 bits (309), Expect = 3e-27
Identities = 64/145 (44%), Positives = 87/145 (59%), Gaps = 22/145 (15%)
Query: 1608 NKNSYNFGTTQNGKEVTDVALPPWAKNDPKIFIEINRQALESRYVSEHLNEWIDLVFGFK 1667
N N YN G ++ V DV LPPWAK P+ F+ INR ALES +VS L++WIDL+FG+K
Sbjct: 4 NSNGYNLGVREDEVVVNDVDLPPWAKK-PEDFVRINRMALESEFVSCQLHQWIDLIFGYK 62
Query: 1668 QRGKEAIKAVNVFNSLSYSGNVDINGIDNDIER---------------------KAITGI 1706
QRG EA++A+NVF+ L+Y G+V+++ I + + R KA+
Sbjct: 63 QRGPEAVRALNVFHYLTYEGSVNLDSITDPVLREIPEAYFIRDPHTFLLTKDFIKAMEAQ 122
Query: 1707 IHNFGQTPLQIFQHPHPPRKCKAYL 1731
I NFGQTP Q+ PHPPR +L
Sbjct: 123 IQNFGQTPSQLLIEPHPPRSSAMHL 147
>At5g18530 [TU] KOG1786 Lysosomal trafficking regulator LYST and related BEACH
and WD40 repeat proteins
Length = 1598
Score = 105 bits (263), Expect = 6e-22
Identities = 101/320 (31%), Positives = 143/320 (44%), Gaps = 61/320 (19%)
Query: 1444 DLWQAGSLSNFDYLMALNTLAGRTFNDLTQYPVFPWVIADYVSDSIDLENPKTYRDLSKP 1503
D W G LSNF+YL+ LN LAGR + D T +PV PWVI D+ S + ++ +RDL K
Sbjct: 349 DKWWKGELSNFEYLLVLNKLAGRRWGDHTFHPVMPWVI-DF-SKKPENDSDSGWRDLRK- 405
Query: 1504 MGAQSEKRMMNFIERFQALKDLDDTSTPPFHYGTHYSSAMIVSSYLVRLQPFADTYKTLQ 1563
S+ R+ E+ L T P H S + V SY R P + K ++
Sbjct: 406 ----SKWRLAKGDEQ---LDFTYSTFEFPHHVSDECLSELAVCSYKARRLPLSVLRKAVR 458
Query: 1564 GDQWGPPDRLFNSVSRA--WTSASSEASTDVRELIPEFYYLPDFLTNKNSYNFGTTQNGK 1621
P+ + + R WT E IPEFY P + +
Sbjct: 459 SVY--EPNEYPSDMQRLYDWTP---------DECIPEFYCDPRIFCSLH----------P 497
Query: 1622 EVTDVALPPWAKNDPKIFIEINRQALESRYVSEHLNEWIDLVFGFKQRGKEAIKAVNVFN 1681
++D+A+PPWA + P FI ++R ALES +VS ++ WID+ FG+K G AI A NV
Sbjct: 498 SMSDLAVPPWA-SSPDEFIRLHRDALESPHVSSLIHHWIDITFGYKMSGHAAITAKNVML 556
Query: 1682 SLSYSGNVDINGIDNDIERKAITGIIHNFGQTPLQIFQHPHPPR------KCKAYLEVED 1735
S S + + R+ Q+F PHP R K ++ E+E
Sbjct: 557 SSSEP------TVPRSVGRR--------------QLFFRPHPVRLGFSREKEQSRNELEM 596
Query: 1736 EDVRKFG-DLKPSINRTADK 1754
FG D K S+ AD+
Sbjct: 597 HTFHGFGVDNKRSVILLADE 616
>7297900_1 [TU] KOG1786 Lysosomal trafficking regulator LYST and related BEACH
and WD40 repeat proteins
Length = 917
Score = 85.5 bits (210), Expect = 8e-16
Identities = 84/296 (28%), Positives = 124/296 (41%), Gaps = 65/296 (21%)
Query: 1444 DLWQAGSLSNFDYLMALNTLAGRTFNDLTQYPVFPWVI----------ADYVSDSIDLEN 1493
++W G LSNFDYL LN GR+ + + + PWV D L
Sbjct: 346 EMWCNGQLSNFDYLTILNNACGRSLTNAAYHHIMPWVTDFSGRGGGAWRDLTKSKYRLNK 405
Query: 1494 PKTYRDLSKPMGAQSEKRMMNFIERFQALKDLDDTSTPPFHYGTHYSSAMIVSSYLVRLQ 1553
+ DL +Q ++ QA+ D P H+ + + S + Y+ R
Sbjct: 406 GDVHLDLMYAHASQHGSADGSY----QAIGD----QAP--HHVSDFLSEITYFVYMARRT 455
Query: 1554 PFADTYKTLQGDQWGPPDRLFNSVSRA--WTSASSEASTDVRELIPEFYYLPDFLTNKNS 1611
P + ++ W P + S+ R WT E IPEFY P + +
Sbjct: 456 PQSILCAHVR-PIWVPAEYPV-SIQRLQEWTPD---------ECIPEFYSDPMIFKSIH- 503
Query: 1612 YNFGTTQNGKEVTDVALPPWAKNDPKIFIEINRQALESRYVSEHLNEWIDLVFGFKQRGK 1671
+++ D+ LP WA P+ FI +R+ALES+YVSE L+ WIDL FG+K GK
Sbjct: 504 ---------EDLPDLELPAWA-TCPEDFICKHREALESQYVSERLHHWIDLNFGYKLSGK 553
Query: 1672 EAIKAVNVFNSL-SYSGNVDINGIDNDIERKAITGIIHNFGQTPLQIFQHPHPPRK 1726
A+K+ NV +L N+ GI +Q+F HPPR+
Sbjct: 554 AAVKSKNVCLTLVDQHRNLSQRGI--------------------VQLFASAHPPRR 589
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.321 0.136 0.390
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 111,976,817
Number of Sequences: 60738
Number of extensions: 4701970
Number of successful extensions: 13228
Number of sequences better than 1.0e-05: 23
Number of HSP's better than 0.0 without gapping: 23
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 13104
Number of HSP's gapped (non-prelim): 61
length of query: 1999
length of database: 30,389,216
effective HSP length: 122
effective length of query: 1877
effective length of database: 22,979,180
effective search space: 43131920860
effective search space used: 43131920860
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)