ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactII1922 check: MH T KOG4305 Signal transduction mechanisms RhoGEF GTPase
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactII1922 686643 682963 -1227
(1227 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YLR371w [T] KOG4305 RhoGEF GTPase 1394 0.0
YGR070w [T] KOG4305 RhoGEF GTPase 941 0.0
SPCC645.07 [T] KOG4305 RhoGEF GTPase 558 e-158
SPAC1006.06 [T] KOG4305 RhoGEF GTPase 538 e-152
SPCC645.06c [T] KOG4305 RhoGEF GTPase 152 2e-36
Hs15011972 [T] KOG3520 Predicted guanine nucleotide exchange factor 88 7e-17
Hs19923327 [T] KOG4305 RhoGEF GTPase 86 4e-16
Hs7662088_2 [T] KOG3520 Predicted guanine nucleotide exchange fa... 86 5e-16
Hs9506401 [T] KOG4305 RhoGEF GTPase 85 8e-16
Hs7662086 [T] KOG3520 Predicted guanine nucleotide exchange factor 80 3e-14
7302841 [T] KOG3520 Predicted guanine nucleotide exchange factor 74 1e-12
Hs4504797_2 [T] KOG4305 RhoGEF GTPase 74 1e-12
Hs21361487 [T] KOG3523 Putative guanine nucleotide exchange fact... 72 7e-12
CE25936 [T] KOG3523 Putative guanine nucleotide exchange factor TIM 70 3e-11
CE19531 [T] KOG3523 Putative guanine nucleotide exchange factor TIM 70 3e-11
7298597 [T] KOG3520 Predicted guanine nucleotide exchange factor 68 8e-11
Hs7662378_2 [T] KOG3523 Putative guanine nucleotide exchange fac... 67 2e-10
CE03899 [T] KOG4424 Predicted Rho/Rac guanine nucleotide exchang... 66 4e-10
Hs4758358 [T] KOG4424 Predicted Rho/Rac guanine nucleotide excha... 65 7e-10
Hs11128045_2 [T] KOG4305 RhoGEF GTPase 65 9e-10
7295262 [T] KOG4424 Predicted Rho/Rac guanine nucleotide exchang... 64 1e-09
Hs14670377 [T] KOG3520 Predicted guanine nucleotide exchange factor 63 3e-09
HsM19923376 [T] KOG3520 Predicted guanine nucleotide exchange fa... 61 1e-08
HsM17933492 [T] KOG3520 Predicted guanine nucleotide exchange fa... 61 1e-08
Hs21493031 [T] KOG3520 Predicted guanine nucleotide exchange factor 61 1e-08
Hs21493029 [T] KOG3520 Predicted guanine nucleotide exchange factor 61 1e-08
Hs21493026 [T] KOG3520 Predicted guanine nucleotide exchange factor 61 1e-08
Hs22046517 [T] KOG3523 Putative guanine nucleotide exchange fact... 60 2e-08
Hs20537850 [T] KOG3523 Putative guanine nucleotide exchange fact... 60 2e-08
Hs15011981 [T] KOG3519 Invasion-inducing protein TIAM1/CDC24 and... 58 8e-08
Hs15011979 [T] KOG3519 Invasion-inducing protein TIAM1/CDC24 and... 58 8e-08
Hs15011974 [T] KOG3520 Predicted guanine nucleotide exchange factor 58 8e-08
CE29438 [T] KOG3522 Predicted guanine nucleotide exchange factor 58 8e-08
CE27826 [T] KOG2996 Rho guanine nucleotide exchange factor VAV3 58 8e-08
YAL041w [T] KOG3519 Invasion-inducing protein TIAM1/CDC24 and re... 57 1e-07
YLR425w [T] KOG4305 RhoGEF GTPase 57 2e-07
Hs4504335 [T] KOG4240 Multidomain protein contains SPEC repeats ... 57 2e-07
Hs5902140_1 [T] KOG0689 Guanine nucleotide exchange factor for R... 57 2e-07
Hs6005922_1 [T] KOG4240 Multidomain protein contains SPEC repeat... 57 2e-07
Hs7657365 [T] KOG3523 Putative guanine nucleotide exchange facto... 56 4e-07
Hs22047180 [T] KOG4424 Predicted Rho/Rac guanine nucleotide exch... 56 4e-07
Hs21245128 [T] KOG4424 Predicted Rho/Rac guanine nucleotide exch... 55 5e-07
Hs4885633 [T] KOG3523 Putative guanine nucleotide exchange facto... 54 1e-06
7292538 [T] KOG4305 RhoGEF GTPase 54 1e-06
Hs20533821 [T] KOG3521 Predicted guanine nucleotide exchange factor 54 2e-06
CE24103 [T] KOG3520 Predicted guanine nucleotide exchange factor 52 4e-06
Hs22054476 [T] KOG3524 Predicted guanine nucleotide exchange fac... 52 6e-06
>YLR371w [T] KOG4305 RhoGEF GTPase
Length = 1356
Score = 1394 bits (3607), Expect = 0.0
Identities = 754/1359 (55%), Positives = 924/1359 (67%), Gaps = 159/1359 (11%)
Query: 13 RRQLFTQIFGIERPL-------SPPPSNVPREL-PDSLD-MMSLKAVLNEDVENDLL--- 60
R +++QIFG+ER S ++ +L P+ ++ + +L +L+ED+ ND++
Sbjct: 12 RNDIYSQIFGVERRPDSFATFDSDSHGDISSQLLPNRIENIQNLNVLLSEDIANDIIIAK 71
Query: 61 -QNRGQI-----------SENKTGTERSVFRSPVHVRQISDVPSMDTEDDIVTPPESTSP 108
+ R + +E K + + +++++ D S+ + D+ TP S
Sbjct: 72 QRRRSGVEAAIDDSDIPNNEMKGKSSNYILSQQTNIKEVPDTQSLSSADN--TPVSSPKK 129
Query: 109 QAYPPEDLSLPKQRPMSH-------------HHHGRPAPPAMDMIHESPRRSKSENF--- 152
+ + MSH H++ P PP M +E +++KS
Sbjct: 130 ARDATSSHPIVHAKSMSHIYSTSNSASRQAKHYNDHPLPP-MSPRNEVYQKNKSTTAFVP 188
Query: 153 NSKPSLPKLSTTGQIXXXXXXXXXXXXXXXXXRGSFSAKKSPLQGFGLFSRSSSKYLQ-- 210
KPSLP+L+ G A+KSPLQGFG FSR SSK L
Sbjct: 189 KRKPSLPQLALAGLKKQSSFSTGSASTTPT------QARKSPLQGFGFFSRPSSKDLHEQ 242
Query: 211 ------------------------ADANLXXXXXXXXXXXDHIFGRTQSISSSTFKNFTS 246
A + I R+ S++SST KN S
Sbjct: 243 HQHHQHIQHNNINNHNNNNTNNNGAHYQVGSSNSNYPQHSHSISSRSMSLNSSTLKNIAS 302
Query: 247 SLHGKTKTVGGRTIPQKYDHSTNPLLD--------------------------------- 273
S KT R QKYD ++NP D
Sbjct: 303 SFQSKTSN--SRKATQKYDITSNPFSDPHHHHHHHHSSNSHSSLNNVHGSGNSSSVMGSS 360
Query: 274 STLGLGIKQRXXXXX------XXXXXXXXRHIRRTSTSSLHTKHIVVSSSIRRPQVYPAM 327
S +GLG+K R RR+S + L V+S+S ++PQVYPA+
Sbjct: 361 SNIGLGLKTRVSSTSLALKRYTSVSGTSLSSPRRSSMTPLSASRPVMSASSKKPQVYPAL 420
Query: 328 LSRVATAFRKSITLCEHKKDGLVYRDAFTGQQAIDVICSIIRTNDRNLALLLGRALDAQK 387
LSRVAT F+ SI L EHKKDGLVYRDAFTGQQA+DVIC+IIRT+DRNLALL GR+LDAQK
Sbjct: 421 LSRVATKFKSSIQLGEHKKDGLVYRDAFTGQQAVDVICAIIRTSDRNLALLFGRSLDAQK 480
Query: 388 LFHDVIYEHRLRDSPNEVYEFTGNSRVIGKG-------IYEIGSTNNFSA---------- 430
LFHDV+YEHRLRDSP+EVYEFT NSR G G + + ++++F++
Sbjct: 481 LFHDVVYEHRLRDSPHEVYEFTDNSRFTGTGSTNAHDPLMLLPNSSSFNSGNHSYPNSGM 540
Query: 431 --SQSSTTIAXXXXXXXXXXXXXXEDLD------SYHQVNGVFTLLAECYSPTCTRNRLC 482
S S++++ L + H VNGVFTLLAECYSPTCTR+ LC
Sbjct: 541 VPSSSTSSLNSDQATLTGSRLHMSSSLSQQKNPAAIHNVNGVFTLLAECYSPTCTRDALC 600
Query: 483 YSISCPKRLEQQARLNLKPNGGLKRNISMAIDDDDEEKSSWTSSVPEELWSSLTKREIKR 542
YSISCP+RLEQQARLNLKPNGGLKRNISMA+DDDDEEK SWTSSV +E W +L K+EIKR
Sbjct: 601 YSISCPRRLEQQARLNLKPNGGLKRNISMALDDDDEEKPSWTSSVSKEDWENLPKKEIKR 660
Query: 543 QEAIYEVYSTEKKFVKSLEILRDTFMKKLAETNIIPADIRKNFIKHVFAHVNDIYSVNRR 602
QEAIYEVY TEK FVKSLEI RDTFMK LAETNII ADIRKNFIKHVFAH+NDIYSVNRR
Sbjct: 661 QEAIYEVYITEKNFVKSLEITRDTFMKTLAETNIISADIRKNFIKHVFAHINDIYSVNRR 720
Query: 603 LLDALSERQKASPIVDGIGDILLRFVPFFEPFVMYVASRPYAKYLIETQRSVNPYFARFD 662
L AL++RQ++SP+V GIGDI+LRF+PFFEPFV YVASRPYAKYLIETQRSVNPYFARFD
Sbjct: 721 FLKALTDRQRSSPVVRGIGDIVLRFIPFFEPFVSYVASRPYAKYLIETQRSVNPYFARFD 780
Query: 663 DDLMNSKLRHGIDSFLSQGVSRPGRYVLLVREIMKSTDPETEKRDLENLTRALEALRAFM 722
DD+M+S LRHGIDSFLSQGVSRPGRY+LLV+EIMKSTDPE +K D E+L++A++ALR FM
Sbjct: 781 DDMMSSSLRHGIDSFLSQGVSRPGRYMLLVKEIMKSTDPEKDKSDYEDLSKAMDALRDFM 840
Query: 723 KRIDKASGAAQDRHDVKLLKQKILFKNEYVNMGLNDDKRKIKHEGLLSRKEITKNENGVT 782
KRID+ASGAAQDRHDVKLLKQKILFKNEYVN+GLND++RKIKHEG+LSRKE++K++ V
Sbjct: 841 KRIDQASGAAQDRHDVKLLKQKILFKNEYVNLGLNDERRKIKHEGILSRKELSKSDGTVV 900
Query: 783 GDLQFYLLDNMLLFLKSKAVNKWNQHKVFQRPIPLPLLFAAPGEEMPSLKRHICGKPDSQ 842
GD+QFYLLDNMLLFLK+KAVNKW+QHKVFQRPIPLPLLFA PGE+MP+L+++I PD
Sbjct: 901 GDIQFYLLDNMLLFLKAKAVNKWHQHKVFQRPIPLPLLFACPGEDMPALRKYIGDHPDCS 960
Query: 843 GMVIYPDAIAGTNPRNAISFTYYGAKNKYQVTLYAAQFAAMQTLLEKIKQEQARIIKEND 902
G VI P+ +NP+NAI+F YYGAK +YQVTLYAAQ+A +QTLLEKIKQ QA II + +
Sbjct: 961 GTVIQPE-YNTSNPKNAITFLYYGAKQRYQVTLYAAQYAGLQTLLEKIKQGQAAIISKTE 1019
Query: 903 IFNVCKISDRYFDYSNKINSVASCDGGRKLIIATSQGLFYSNIRRAEN-------SIIFG 955
+FNV K+SDR+FDY+NKINSV SCDGGRKL+IAT+ GL+ SNI+R +N S F
Sbjct: 1020 MFNVTKMSDRFFDYTNKINSVTSCDGGRKLLIATNSGLYMSNIKRQQNKDHRHKSSAFFS 1079
Query: 956 APTKLLTKSNISQLSVLEEFQSILILADKKLYSCSFDILKITDPQAGNTYFKKHAKELVT 1015
P +L+ ++NI+Q++VLEEF+SI++L DKKLYSC +++ G ++FKKH KEL+
Sbjct: 1080 TPIQLVQRNNITQIAVLEEFKSIILLIDKKLYSCPLSLIEAEG--NGTSFFKKHHKELIN 1137
Query: 1016 HVSFFSDGDCNGKKLIVTAHTSHNSIKY--------XXXXXXXXXXXXXXXXXXXXVEFD 1067
HVSFF++GDCNGK+LIVTAH+S +SIKY V FD
Sbjct: 1138 HVSFFAEGDCNGKRLIVTAHSSSHSIKYFEHEHPLLAEKNGSGSGNKKSLKKKITEVIFD 1197
Query: 1068 SEPVSISFLKANLCIGCKKGFQIVSVSQNAHEPLLDPADTSLDFALKDSLHPQVIYRVGN 1127
SEPVSISFLKANLCIGCKKGFQIVS+SQNAHE LLDPADTSL+FAL+D+L P IYRVGN
Sbjct: 1198 SEPVSISFLKANLCIGCKKGFQIVSISQNAHESLLDPADTSLEFALRDTLKPMAIYRVGN 1257
Query: 1128 MFFLCYTEFAFFVNNQGWRKKEYNVVHWEGEPEKFAIWYPYIIAFDSNFIEIRKVETGEL 1187
MF LCYTEFAFFVNNQGWRKKE +++HWEGEP+KFAIWYPYI+AFDSNFIEIRK+ETGEL
Sbjct: 1258 MFLLCYTEFAFFVNNQGWRKKESHIIHWEGEPQKFAIWYPYILAFDSNFIEIRKIETGEL 1317
Query: 1188 IRCVVGEKIRLLQTSSQEILYVYEDERGYDTIASLDFWG 1226
IRCV+ +KIRLLQTS+QEILY YED RGYDT+ASLDFWG
Sbjct: 1318 IRCVLADKIRLLQTSTQEILYCYEDYRGYDTVASLDFWG 1356
>YGR070w [T] KOG4305 RhoGEF GTPase
Length = 1155
Score = 941 bits (2432), Expect = 0.0
Identities = 490/943 (51%), Positives = 654/943 (68%), Gaps = 40/943 (4%)
Query: 297 RHIRRTSTSSLHTKHIVVSSSIRRPQVYPAMLSRVATAFRKSITLCEHKKDGLVYRDAFT 356
RH R+ +S + I + P VYPA+LS +A F+++I L HKK GL+YRD+FT
Sbjct: 238 RHHSRSKSSPVSLTEISMIKGT--PLVYPALLSLIAIKFKQTIKLSTHKKMGLLYRDSFT 295
Query: 357 GQQAIDVICSIIRTNDRNLALLLGRALDAQKLFHDVIYEHRLRDSPNEVYEFTGNSRVIG 416
G+QAID +C II + DRNL +L+G++L+AQKLFHDV+Y+H +RDS E+YE + S +
Sbjct: 296 GKQAIDTLCLIIGSLDRNLGMLIGKSLEAQKLFHDVLYDHGVRDSVLEIYELSSESIFMA 355
Query: 417 KGIYEIGSTNNFSASQSSTTIAXXXXXXXXXXXXXXEDLDSYHQVNGVFTLLAECYSPTC 476
SQSST+IA L + ++ GVF L CYS TC
Sbjct: 356 H------------QSQSSTSIANTFSSSSSSV----NSLRTKTEIYGVFVPLTHCYSSTC 399
Query: 477 TRNRLCYSISCPKRLEQQARLNLKPNGGLKRNISMAIDDDDEEKSSWTSSVPEELWSSLT 536
+ +LCYSISCP RL+QQA L+LK GGLKRNIS+A+D +D+E+ SWT+SVP+ +W SL+
Sbjct: 400 SLEKLCYSISCPNRLQQQANLHLKLGGGLKRNISLALDKEDDERISWTNSVPKSVWESLS 459
Query: 537 KREIKRQEAIYEVYSTEKKFVKSLEILRDTFMKKLAETNIIPADIRKNFIKHVFAHVNDI 596
K++IKRQEAIYE+++TEKKFVKSLEI+RDTFMKKL ETNIIP+D+R NF+KHVFAH+N+I
Sbjct: 460 KQQIKRQEAIYELFTTEKKFVKSLEIIRDTFMKKLLETNIIPSDVRINFVKHVFAHINEI 519
Query: 597 YSVNRRLLDALSERQKASPIVDGIGDILLRFVPFFEPFVMYVASRPYAKYLIETQRSVNP 656
YSVNR L AL++RQ SPI GI DI L+++PFF+PF+ Y+ASRPYAKYLIETQRSVNP
Sbjct: 520 YSVNREFLKALAQRQSLSPICPGIADIFLQYLPFFDPFLSYIASRPYAKYLIETQRSVNP 579
Query: 657 YFARFDDDLMNSKLRHGIDSFLSQGVSRPGRYVLLVREIMKSTDPETEKRDLENLTRALE 716
FARFDD++ NS LRHGIDSFLSQGVSRPGRY LLVREI+ +DP T+K DL+ L + +
Sbjct: 580 NFARFDDEVSNSSLRHGIDSFLSQGVSRPGRYSLLVREIIHFSDPVTDKDDLQMLMKVQD 639
Query: 717 ALRAFMKRIDKASGAAQDRHDVKLLKQKILFKNEYVNMGLNDDKRKIKHEGLLSRKEITK 776
L+ MKRID+ASGAAQDR+DVK+LKQKILFKNEYVN+GLN++KRKIKHEGLLSRK++ K
Sbjct: 640 LLKDLMKRIDRASGAAQDRYDVKVLKQKILFKNEYVNLGLNNEKRKIKHEGLLSRKDVNK 699
Query: 777 NENGVTGDLQFYLLDNMLLFLKSKAVNKWNQHKVFQRPIPLPLLFAAPGEEMPSLKRHIC 836
+ +GD+QFYLLDNMLLFLKSKAVNKW+QH VFQRPIPLPLLF P E+MP +KR++
Sbjct: 700 TDASFSGDIQFYLLDNMLLFLKSKAVNKWHQHTVFQRPIPLPLLFICPAEDMPPIKRYVT 759
Query: 837 GKPDSQGMVIYPDAIAGTNPRNAISFTYYGAKNKYQVTLYAAQFAAMQTLLEKIKQEQAR 896
P+ V+ P +NP+NAI F YYG K +YQVTLYA Q A +QTL+EK+KQEQ R
Sbjct: 760 ENPNCSAGVLLPQ-YQTSNPKNAIVFAYYGTKQQYQVTLYAPQPAGLQTLIEKVKQEQKR 818
Query: 897 IIKENDIFNVCKISDRYFD---YSNKINSVASCDGGRKLIIATSQGLFYSNIRRAENSII 953
++ E ++ ++F +N++N V C G+ L++AT+ GLF N + N
Sbjct: 819 LLDETKHITFKQMVGQFFHSYINTNRVNDVLICHAGKILLVATNMGLFVLNYATSINQ-- 876
Query: 954 FGAPTKLLTKSNISQLSVLEEFQSILILADKKLYSCSFDILKITDPQAGNTYFKKHAKEL 1013
P LL K +ISQ+SVLEE++ +++L DKKLY C D+ I D + + F+K++K L
Sbjct: 877 --KPVHLLHKISISQISVLEEYKVMILLIDKKLYGCPLDV--IDDAENADFLFRKNSKVL 932
Query: 1014 VTHVSFFSDGDCNGKKLIVTAHTSHNSIKYXX---XXXXXXXXXXXXXXXXXXVEF--DS 1068
+V+ F DG CNGK++I+ AH ++ + V+F DS
Sbjct: 933 FKYVAMFKDGFCNGKRIIMIAHHFLHAAQLLIVNPLIFDFNSGNFKKNLKAGLVDFSVDS 992
Query: 1069 EPVSISFLKANLCIGCKKGFQIVSVSQNAHE------PLLDPADTS-LDFALKDSLHPQV 1121
EP+S SFL+ +CIGCKK +I++V + + LL+ D L K++
Sbjct: 993 EPLSFSFLENKICIGCKKNIKILNVPEVCDKNGFKMRELLNLHDNKVLANMYKETFKVVS 1052
Query: 1122 IYRVGNMFFLCYTEFAFFVNNQGWRKKEYNVVHWEGEPEKFAIWYPYIIAFDSNFIEIRK 1181
++ + N F C+ E FF+N QG R++ HWEGEPE+FA YPYI+A +SNFIEIR
Sbjct: 1053 MFPIKNSTFACFPELCFFLNKQGKREETKGCFHWEGEPEQFACSYPYIVAINSNFIEIRH 1112
Query: 1182 VETGELIRCVVGEKIRLLQTSSQEILYVYEDERGYDTIASLDF 1224
+E GEL+RCV+G KIR+L++ +++ILY YED +G++ I L+F
Sbjct: 1113 IENGELVRCVLGNKIRMLKSYAKKILYCYEDPQGFEIIELLNF 1155
>SPCC645.07 [T] KOG4305 RhoGEF GTPase
Length = 1334
Score = 558 bits (1437), Expect = e-158
Identities = 356/1014 (35%), Positives = 535/1014 (52%), Gaps = 84/1014 (8%)
Query: 237 SSSTFKNFTSSL-------HGKTKTVGGRTIPQK---YDHST----NPLLDSTLGLGIKQ 282
S+S+ KN S L HG + T+ R + +DHST + LG+
Sbjct: 306 SASSHKNIFSGLDVFSNVFHGPSTTLRDREHDMRNRSFDHSTLAHYEAVKQQRLGVEPTA 365
Query: 283 RXXXXXXXXXXXXXRHI--RRTSTSSLHTKHIVVSSSI----RRPQVYPAMLSRVATAFR 336
R + R+ST++ + SS + RR ++Y A+LSRVA+
Sbjct: 366 RSFTLSSYKSRASGNSLINDRSSTTTPTFVNSEASSPVHKNKRRRRIYAALLSRVASELL 425
Query: 337 KSITLCEHKKDGLVYRDAFTGQQAIDVICSIIRTNDRNLALLLGRALDAQKLFHDVIYEH 396
+ L + KDGL+Y +AFTG A+ V+ II T+DRNLALL+GR+LDAQK HDV Y+H
Sbjct: 426 DRLQLGDITKDGLIYSNAFTGDHAVTVLMGIIHTSDRNLALLVGRSLDAQKFIHDVTYDH 485
Query: 397 RLRDSPNEVYEFTGNSRVIGKGIYEIGSTNNFSASQSSTTIAXXXXXXXXXXXXXXEDLD 456
RLRDS E+Y+ G Y N +AS ++ L
Sbjct: 486 RLRDSHREIYQLQGTG-------YRPFLRANDNASINNKNHHKELEDNESGTRISPSTLG 538
Query: 457 SYHQVNGVFTLLAECYSPTCTRNRLCYSISCPKRLEQQARLNLKPNGGLKRNISMAIDDD 516
NG+FTLL CYSPTC ++ CYSISCP+RLEQQ RL K +++ S+A DD
Sbjct: 539 DTSFPNGIFTLLTHCYSPTCAKDHPCYSISCPRRLEQQHRLFAKMRANTEQSSSLAFDD- 597
Query: 517 DEEKSSWTSSVPEELWSSLTKREIKRQEAIYEVYSTEKKFVKSLEILRDTFMKKLAETNI 576
+E+ W SVP+E+ S++ RE KRQE I EV TE+ FVK LE LRD ++K L ++
Sbjct: 598 -KEQKLWIHSVPQEIAYSVSDRERKRQEVICEVIYTERDFVKDLEYLRDYWIKPLWASSC 656
Query: 577 IPADIRKNFIKHVFAHVNDIYSVNRRLLDALSERQKASPIVDGIGDILLRFVPFFEPFVM 636
IP ++ FI+ VF + ++ +VN +L +AL++RQ PIVD I DI L VP FEPF+
Sbjct: 657 IPERKKEKFIRTVFLNALEVQAVNSKLAEALTKRQNYKPIVDNIADIFLEHVPKFEPFIR 716
Query: 637 YVASRPYAKYLIETQRSVNPYFARFDDDL--MNSKLRHGIDSFLSQGVSRPGRYVLLVRE 694
Y A + Y KY E ++S NP FA+F D+ + + ++ +L++ +R RY LL+
Sbjct: 717 YGAGQLYGKYEFEKEKSSNPAFAKFVSDVERLKESRKLELNGYLTKPTTRLARYPLLLEA 776
Query: 695 IMKSTDPETEKRDLENLTRALEALRAFMKRIDKASGAAQDRHDVKLLKQKILFK-NEYVN 753
++K TD D +++ + + +R F+ R++ SG A+++ ++ L Q+++FK E+ +
Sbjct: 777 VLKYTDEGNP--DKQDIPKVINIVRGFLSRLNVESGKAENKFNLFHLNQQLVFKPGEHYD 834
Query: 754 MGLNDDKRKIKHEGLLSRKEITKNENGVTGDLQFYLLDNMLLFLKSKAVNKWNQHKVFQR 813
+ L D R++ +G L ++ + D+ +L D+ LL +K K +NK KVFQR
Sbjct: 835 LHLLDANRQLIFKGPLKKRSAGSTSSESASDVTLFLFDHALLIVKPKTINKRELLKVFQR 894
Query: 814 PIPLPLLFA------------APGEEMPSLKRHICGKPDSQGMVIYPDAIAGTNPRNAIS 861
PIPL LL + +++ ++ + GKP S+ YP ++ R
Sbjct: 895 PIPLLLLQLFLVDDNGLRIPYSSKQQLAAVSKAANGKPPSR---FYPFSLQLLGRRG--- 948
Query: 862 FTYYGAKNKYQVTLYAAQFAAMQTLLEKIKQEQARIIKENDIFNVCKISDRYFDYSNKIN 921
Y++TLYA + LE I +Q + N F I +F NK+N
Sbjct: 949 ---------YEITLYATTEVSRDKWLEHIDNQQTLLQHRNQWFESVTICSNFFVGDNKVN 999
Query: 922 SVASCDGGRKLIIATSQGLFYSNIRRAENSIIFGAPTKLLTKSNISQLSVLEEFQSILIL 981
++ D GR+L+ T G+ Y ++R+A + + F P + L NISQL V+EE+ +L+L
Sbjct: 1000 AIGVYDSGRRLLYGTDTGV-YVSLRKANSPLQF-KPVRALNIPNISQLEVIEEYSLLLLL 1057
Query: 982 ADKKLYSCSFDILKITDPQAGNTYFKKHAKELVTHVSFFSDGDCNGKKLIVTAH------ 1035
+DK LYS +++ A T K A+++ H +FF G C GK L+
Sbjct: 1058 SDKVLYSYPLEMI-----DADTTQAPKKARKVSGHTTFFRVGICLGKVLVCAVKSSVLSA 1112
Query: 1036 --------TSHNSIKYXXXXXXXXXXXXXXXXXXXXVEFDSEPVSISFLKANLCIGCKKG 1087
T+++ + + +E S+ FLK LC+GC +G
Sbjct: 1113 TIKVFEPVTNYSKTRNMPSLKKFLTVNQDPLRIVKELYIPTESTSVHFLKNKLCVGCTRG 1172
Query: 1088 FQIVSVSQNAHEPLLDPADTSLDFA-LKDSLHPQVIYRV-GNMFFLCYTEFAFFVNNQGW 1145
F++VS+ + LLDPADTSL+F K+++ P IYR+ G F LCY++FAF+VN GW
Sbjct: 1173 FEVVSLDNLETQSLLDPADTSLEFVEKKENVKPIAIYRMNGGEFLLCYSQFAFYVNRDGW 1232
Query: 1146 RKKEYNVVHWEGEPEKFAIWYPYIIAFDSNFIEIRKVETGELIRCVVGEKIRLL 1199
R + V WEG P+ FA+ YPYI+AF+ FIEIR VET ELI + G IRLL
Sbjct: 1233 RSRPTWFVVWEGSPQNFALSYPYILAFEPTFIEIRHVETSELIHVISGRNIRLL 1286
>SPAC1006.06 [T] KOG4305 RhoGEF GTPase
Length = 1158
Score = 538 bits (1386), Expect = e-152
Identities = 329/952 (34%), Positives = 516/952 (53%), Gaps = 67/952 (7%)
Query: 315 SSSIRRPQVYPAMLSRVATAFRKSITLCEHKKDGLVYRDAFTGQQAIDVICSIIRTNDRN 374
S+S RRP ++PA LS+VA FRK + + + KDGL+Y+DAF G +A+DV+ I+RT DRN
Sbjct: 192 STSSRRPYIHPAFLSQVAVEFRKRLNIGDRVKDGLLYKDAFLGSEAVDVLMHIVRTTDRN 251
Query: 375 LALLLGRALDAQKLFHDVIYEHRLRDSPNEVYEF--------------TGNSRVIGKGIY 420
LALLLGRALD+QK+FHDV Y HRLRDS EVY++ + S + +Y
Sbjct: 252 LALLLGRALDSQKMFHDVTYSHRLRDSLKEVYQYRRIISPPPGLSSMDSNGSSIENNFLY 311
Query: 421 ---EIGSTNNFSA--SQSSTTIAXXXXXXXXXXXXXXEDL----------DSYHQVNGVF 465
++++F + S SSTT L ++ + +GVF
Sbjct: 312 TKRRANTSDSFDSVLSDSSTTPTISSSVQVNSLAFITSSLSAITKEPEAPETEYNPHGVF 371
Query: 466 TLLAECYSPTCTRNRLCYSISCPKRLEQQARLNLKPNGGLKRNISMAIDDDDEEKSSWTS 525
TLL ECYS TC+RNRLCYSISCP+RLEQQARL+LK L + D +E+ W+
Sbjct: 372 TLLTECYSSTCSRNRLCYSISCPRRLEQQARLHLKVQPVLSGGSTSITDKQEEDHRLWSE 431
Query: 526 SVPEELWSSLTKREIKRQEAIYEVYSTEKKFVKSLEILRDTFMKKLAETNIIPADIRKNF 585
+VP+++ + RE KRQE I+EV TE+ FV+ LE +RD ++K L+ +N+IP + R+ F
Sbjct: 432 NVPKQVVDQIDVREWKRQEIIFEVIYTERDFVRDLEYIRDFWIKPLSTSNVIPENNRQQF 491
Query: 586 IKHVFAHVNDIYSVNRRLLDALSERQKASPIVDGIGDILLRFVPFFEPFVMYVASRPYAK 645
I+ VF ++ I++VN RL +AL+ Q P+V+ IGD+ L +VP FEPF+ Y A++ AK
Sbjct: 492 IRCVFHNIMQIHAVNSRLSNALNRTQTLQPVVNTIGDLFLDYVPKFEPFIKYGANQAIAK 551
Query: 646 YLIETQRSVNPYFARF--DDDLMNSKLRHGIDSFLSQGVSRPGRYVLLVREIMKSTDPET 703
+ E ++S N FA + + + + + ++ +L++ +R RY LL+ ++K TD +
Sbjct: 552 FEFEREKSTNRNFANYVHEVERLRESRKLELNGYLTKPTTRLARYPLLLSGVLKYTDKDN 611
Query: 704 EKRDLENLTRALEALRAFMKRIDKASGAAQDRHDVKLLKQKI-LFKNEYVNMGLNDDKRK 762
D EN+ R +E +R F+ +++ +G ++R + L +++ + + L D R
Sbjct: 612 P--DTENIPRVIEMIREFLTKLNYETGKTENRLSLLQLNEQLSCSPADRAKLTLFDPSRL 669
Query: 763 IKHEGLLSRKEITKNENGVTGDLQFYLLDNMLLFLKSKAVNKWNQHKVFQRPIPLPLLFA 822
+ +G++ K + + D+ +LLDN LL K K K HK+ RP+PL LL
Sbjct: 670 LIFKGVVKLKASSYSNGDTENDIHMFLLDNFLLLCKIKIQMKRRVHKLHLRPLPLELLSI 729
Query: 823 APGEEMPSLKRHICGKPDSQGMVIYPDAIAGTNP----RNAISFTYYGAKNKYQVTLYAA 878
+ E+ PS R + S ++ P +I +NP + + GA+ + ++LY
Sbjct: 730 SYIEDSPS--RGSLPRRPSSALLTNPISITKSNPPPVKAYGLQLVFIGARG-FSISLYLN 786
Query: 879 QFAAMQTLLEKIKQEQARIIKENDIFNVCKISDRYFDYSNKINSVASCDGGRKLIIATSQ 938
A + I+++Q I K + +F I + + NK+ + D GRKL+ T +
Sbjct: 787 TLIARDQWKQHIEKQQDIIRKRHLVFESRGICCQSWFTGNKLLCAVAYDAGRKLLFGTYK 846
Query: 939 GLFYSNIRRAENSIIFGAPTKLLTKSNISQLSVLEEFQSILILADKKLYSCSFDILKITD 998
GL+ S+ + S + P L NISQL V+EE +L+LA+K LY D L +
Sbjct: 847 GLYISSRKSNNGSCL--EPIFKLQLPNISQLDVIEEHNVLLLLAEKILYELPLDALDSVE 904
Query: 999 PQAGNTYFKKHAKELVTHVSFFSDGDCNGKKLI-----------VTAHTSHNSIKYXXXX 1047
K + + HVSF G C + L+ + + + ++K
Sbjct: 905 -----QINSKSLRRVTGHVSFVKTGFCMQRILVCAVKSTVLNTTLRIYEADRALKNKKTQ 959
Query: 1048 XXXX-XXXXXXXXXXXXVEFDSEPVSISFLKANLCIGCKKGFQIVSVSQNAHEPLLDPAD 1106
V+ E +S+ FLK LC+G KGF I+S+ + LL+PAD
Sbjct: 960 SLKKPFGNQATLKIFTEVQMPMEALSVHFLKTKLCVGSFKGFDIISLENAVFQSLLNPAD 1019
Query: 1107 TSLDFALK-DSLHPQVIYRVGNMFFLCYTEFAFFVNNQGWRKKEYNVVHWEGEPEKFAIW 1165
TS F K + + P ++R+ F LCY++FAFFVN GW+ ++ +++WEG+P+ A+
Sbjct: 1020 TSFRFLEKREDIRPIAMFRLRGEFLLCYSDFAFFVNTNGWKSRQSWMINWEGQPQGCALC 1079
Query: 1166 YPYIIAFDSNFIEIRKVETGELIRCVVGEKIRLLQ------TSSQEILYVYE 1211
YPYI+AF+ +FIEIR ET EL++ ++G+ I+LL + EILY E
Sbjct: 1080 YPYILAFEPDFIEIRNAETAELVQIIMGQNIKLLTDGRGLISEGGEILYSTE 1131
>SPCC645.06c [T] KOG4305 RhoGEF GTPase
Length = 1275
Score = 152 bits (385), Expect = 2e-36
Identities = 206/861 (23%), Positives = 340/861 (38%), Gaps = 160/861 (18%)
Query: 471 CYSPTCTRNRLCYSISCPKRLEQQARLNLKPNGGLKRNISMAIDDDDEEKSSWTSSVPEE 530
C S +C CYS C + N L+ S+ D W S
Sbjct: 408 CRSRSCPSKYQCYSCRCAR------------NSSLEFT-SLPGQSSDTWSIFWNISSLNS 454
Query: 531 LWSSLTKREIKRQEAIYEVYSTEKKFVKSLEILRDTFMKKLAETN--IIPADIRKNFIKH 588
L SSL+KREI RQ I+E+ E +V L L + F + + I+P++ +FI+
Sbjct: 455 LPSSLSKREIARQNNIHELICKESDYVADLNTLAELFRDGIVQQQDAIVPSNRVADFIQS 514
Query: 589 VFAHVNDIYSVNRRL-LDALSERQK-ASPIVDGIGDILLRFVPFFE-PFVMYVASRPYA- 644
VF +V I ++ RL L L R++ P+V IGDILL ++ + ++ Y P A
Sbjct: 515 VFGNVESIRQLHSRLFLPQLIMRERLQGPVVSIIGDILLEWIHAAKSSYINYAKQFPLAD 574
Query: 645 -KYLIETQRSVNPYFARFDDDLMNSKLRHGID--SFLSQGVSRPGRYVLLVREIMKSTDP 701
Y +E QR N YFAR+ + +D FL + R RY L + I+K T
Sbjct: 575 ETYKLECQR--NTYFARWLAACRSDPRCRRLDFQHFLQRPTQRLQRYTLELDTILKHT-- 630
Query: 702 ETEKRDLENLTRALEALRAFMKRIDKASGAAQDRHDVKLLKQKILFKN-EYVNMGLNDDK 760
E D + +T+A++ LRA + D + + ++ L ++LFKN E VN+ L D +
Sbjct: 631 EQSSWDFQLITQAVKELRATCEECDAVIATVLEANRIRDLSYQLLFKNHESVNLELRDPE 690
Query: 761 RKIKHEGLLSRKEITKNENGVTGDLQFYLLDNMLLFLKSKAVNKWN--QHKVFQRPIPLP 818
R+ EG++ R+ ++ + D+ +LLDN L+ K++ + N ++ V +RPIPL
Sbjct: 691 REFFFEGIVQRRSDSRLD---WLDIHLFLLDNYLIMAKARKDKRTNASRYVVSKRPIPLD 747
Query: 819 LLFAAPGEEMPSLKRH-------ICGKPDSQGMV------------IYPDAIAGTNPRNA 859
LL +P + LK + + G + + + DA A N N+
Sbjct: 748 LLVLSPKMDDFQLKSNTNKFLGSLAGNLPQESLTTKSKRKSKVNLELMFDATAEKNNENS 807
Query: 860 ISFTYYGAKNKY------------QVTLYAAQFAAMQTLLEKI---KQEQARIIKENDIF 904
++ + Y TLY + +EKI K+ ++ I + F
Sbjct: 808 MNSAVFEKSQLYPFTIRHLGAYTASYTLYVESLQLRKLWVEKINVAKKRHSQKINIKNPF 867
Query: 905 NVCKISDRYFDY--------------------------SNKINSVA-------------- 924
+ +SD F Y +N VA
Sbjct: 868 ALKVVSDVAFQYPPSDLVNGNEPLNSFNEITLVEGSSIDRALNEVAWKHPIVSEELLPEP 927
Query: 925 ------SC-------DGGRKLIIATSQGLFYSNIRRAENSIIFGAPTKLLTKSNISQLSV 971
SC +G ++IATS G+F + + + K+ ++ ++QL V
Sbjct: 928 IAYGDISCIAQFNDYEGHVSVLIATSTGIFLGAFGDSSDIRDW---KKISSQRRVTQLGV 984
Query: 972 LEEFQSILILADKKLYSCSFD-----------ILKITDPQAGNTYFK----------KHA 1010
+EEF +L L DK LY+ I + ++FK K
Sbjct: 985 VEEFDILLELRDKTLYAHKLSRIIEMGLIESKIAVVIGTPHAVSFFKIGKLSEGASVKRE 1044
Query: 1011 KELVTHVSFFSDGDCNGKKLIV---TAHTSHNSIKYXXXXXXXXXXXXXXXXXXXXVEFD 1067
+ LV F+ +G N +I HN K
Sbjct: 1045 RTLV----FYKEGLGNTTTIICCEPVIGLGHNYQK----TYAFKRKDVTSFRTLDDFHVT 1096
Query: 1068 SEPVSISFLKANLCIGCKKGFQIVSVSQNAHEPLLDPA---DTSLDFALKDSLHPQVIYR 1124
+ SI K ++ + KG ++ + P+ DT + +S P ++R
Sbjct: 1097 ANCHSIDCFKYSIALCHNKGIDVLRLDPKLAVGFPSPSVLNDTLFRNRINNS-KPLGVFR 1155
Query: 1125 V--GNMFFLCYTEFAFFVNNQGWRKKEYNVVHWEGEPEKFAIWYPYIIAFDSNFIEIRKV 1182
+ ++F CY A FVN +G + W G+P + Y+IAF+ F+EI
Sbjct: 1156 IHDPSLFACCYQFGAVFVNGEGSMVNKECWFDWIGKPNSVTSCHGYLIAFNDEFVEIWNT 1215
Query: 1183 ETGELIRCVVGEKIRLLQTSS 1203
T +L + + G I+ ++S
Sbjct: 1216 RTRKLNQIIQGNDIKYYPSNS 1236
>Hs15011972 [T] KOG3520 Predicted guanine nucleotide exchange factor
Length = 912
Score = 88.2 bits (217), Expect = 7e-17
Identities = 84/334 (25%), Positives = 159/334 (47%), Gaps = 32/334 (9%)
Query: 484 SISCPKRLEQQARLNLKPNGGLKRNISMAIDDDDEEKSSWTSSVPEELWSSLTKREIKRQ 543
S++ P+ ++ A G ++ + EE W VP + SL K ++KRQ
Sbjct: 359 SLAPPESTDEGAETESPEPGDEGEPGRSGLELEPEEPPGWRELVPPDTLHSLPKSQVKRQ 418
Query: 544 EAIYEVYSTEKKFVKSLEILRDTFMKKLAETNIIPADIRKNFIKHVFAHVNDIYSVNRRL 603
E I E+ TE V+ L +L D F + +AE P + +N +F ++++ V+
Sbjct: 419 EVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEELQN----IFPSLDELIEVHSLF 474
Query: 604 LDAL-SERQKASPIVDGIGDILL-RFVPFFEPFVMYVASR-----PYAKYLIETQRSVNP 656
LD L RQ++ +++ IGD+LL RF + ++SR +A ++ ++ +P
Sbjct: 475 LDRLMKRRQESGYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAKQRKDP 534
Query: 657 YFARFDDDLMNSK--LRHGIDSFLSQGVSRPGRYVLLVREIMKSTDPETEKRDLENLTRA 714
F F + + R + + + R +Y LL++ I ++T+ TE+ E + A
Sbjct: 535 RFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEEPTER---EKVELA 591
Query: 715 LEALRAFMKRIDKASGAAQD---------RHDVKLLKQKI-LFKNEYVNMGLNDDKRKIK 764
E R + +++A +D R D+ L+Q +E+ N+ + K+K+
Sbjct: 592 AECCREILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSDPMLSEFKNLDIT--KKKLV 649
Query: 765 HEGLLSRKEITKNENGVTGDLQFYLLDNMLLFLK 798
HEG L+ + +TK++ ++ LLD++LL L+
Sbjct: 650 HEGPLTWR-VTKDK---AVEVHVLLLDDLLLLLQ 679
>Hs19923327 [T] KOG4305 RhoGEF GTPase
Length = 542
Score = 85.9 bits (211), Expect = 4e-16
Identities = 73/297 (24%), Positives = 149/297 (49%), Gaps = 21/297 (7%)
Query: 523 WTSSVPEELWSSLTKREIKRQEAIYEVYSTEKKFVKSLEILRDTFMKKLAETNIIPADIR 582
W+ + + SLT REI+RQEAIYE+ E+ ++ L++ R + + + +I +
Sbjct: 102 WSEMLDITMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKLSI----MS 157
Query: 583 KNFIKHVFAHVNDIYSVNRRLLDALSERQKASPIVDGIGDILLRFVPFFEPFVMYVASRP 642
+ + H+F ++ ++ LL + E K V+ IG IL+ ++P + Y +++
Sbjct: 158 EEELTHIFGDLDSYIPLHEDLLTRIGEATKPDGTVEQIGHILVSWLPRLNAYRGYCSNQL 217
Query: 643 YAKYLIETQRSVNPYFARFDDDLMNSKLRHGID--SFLSQGVSRPGRYVLLVREIMKSTD 700
AK L++ Q+ +P F + S +D SFL SR +Y LL++EI+K T
Sbjct: 218 AAKALLD-QKKQDPRVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPLLLKEILKHT- 275
Query: 701 PETEKRDLENLTRALEALRAFMKRIDKASGAAQDRHDVKLLKQKILFKNEYVNMGLNDDK 760
E D++ L A+ ++ + I+ G ++ ++ + K EY++ D +
Sbjct: 276 -PKEHPDVQLLEDAILIIQGVLSDINLKKGESECQYYID--------KLEYLDEKQRDPR 326
Query: 761 RKIKHEGLLSRKEITKNENGVTGDLQFYLLDNMLLFLKSKAVNKWNQHKVFQRPIPL 817
+ + LL E+ ++++G L +L ++L+ + N+ + ++V+++PIP+
Sbjct: 327 IEAS-KVLLCHGEL-RSKSG--HKLYIFLFQDILVLTRPVTRNERHSYQVYRQPIPV 379
>Hs7662088_2 [T] KOG3520 Predicted guanine nucleotide exchange factor
Length = 1399
Score = 85.5 bits (210), Expect = 5e-16
Identities = 79/307 (25%), Positives = 160/307 (51%), Gaps = 33/307 (10%)
Query: 514 DDDDEEKSSWTSSVPEELWSSLTKREIKRQEAIYEVYSTEKKFVKSLEILRDTFMKKLAE 573
+D + + +W V E+ L EIKRQE I E++ TE+ V++L++L F ++++
Sbjct: 615 NDLETDPPNWQQLVSREVLLGLKPCEIKRQEVINELFYTERAHVRTLKVLDQVFYQRVSR 674
Query: 574 TNII-PADIRKNFIKHVFAHVNDIYSVNRRL---LDALSERQKASPIVDGIGDILLRFV- 628
I+ P+++RK +F+++ DI ++ L + A+ +R + S ++D IG+ LL +
Sbjct: 675 EGILSPSELRK-----IFSNLEDILQLHIGLNEQMKAVRKRNETS-VIDQIGEDLLTWFS 728
Query: 629 -PFFEPF----VMYVASRPYAKYLIETQRSVNPYFARFDDDLMNSKL--RHGIDSFLSQG 681
P E + +++P+A +I++++ + F F D ++ L R + +
Sbjct: 729 GPGEEKLKHAAATFCSNQPFALEMIKSRQKKDSRFQTFVQDAESNPLCRRLQLKDIIPTQ 788
Query: 682 VSRPGRYVLLVREIMKSTDPETEKRDLENLTRALEALRAFMKRIDKASGAAQDRHDVKLL 741
+ R +Y LL+ I K T+ TE+ E + +A + R + +++A A+++ ++
Sbjct: 789 MQRLTKYPLLLDNIAKYTEWPTER---EKVKKAADHCRQILNYVNQAVKEAENKQRLEDY 845
Query: 742 KQKI----LFKNEYVNM----GLNDDKRKIKHEGLLSRKEITKNENGVTGDLQFYLLDNM 793
++++ L +EY N+ L+ KRK+ HEG L + K T DL LL+++
Sbjct: 846 QRRLDTSSLKLSEYPNVEELRNLDLTKRKMIHEGPL----VWKVNRDKTIDLYTLLLEDI 901
Query: 794 LLFLKSK 800
L+ L+ +
Sbjct: 902 LVLLQKQ 908
>Hs9506401 [T] KOG4305 RhoGEF GTPase
Length = 526
Score = 84.7 bits (208), Expect = 8e-16
Identities = 68/298 (22%), Positives = 147/298 (48%), Gaps = 23/298 (7%)
Query: 523 WTSSVPEELWSSLTKREIKRQEAIYEVYSTEKKFVKSLEILRDTFMKKLAETNIIPADIR 582
W+ + + LT +EIKRQEAI+E+ E+ ++ L++ + + + + +I +
Sbjct: 104 WSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSI----MT 159
Query: 583 KNFIKHVFAHVNDIYSVNRRLLDALSERQKASPIVDGIGDILLRFVPFFEPFVMYVASRP 642
+ + +F ++ + ++ LL L + +K + +G IL+ ++P + Y +++
Sbjct: 160 EQELNQIFGTLDSLIPLHEELLSQLRDVRKPDGSTEHVGPILVGWLPCLSSYDSYCSNQV 219
Query: 643 YAKYLIETQRS---VNPYFARFDDDLMNSKLRHGIDSFLSQGVSRPGRYVLLVREIMKST 699
AK L++ ++ V + R + + KL + +FL SR +Y LL+REI++ T
Sbjct: 220 AAKALLDHKKQDHRVQDFLQRCLESPFSRKL--DLWNFLDIPRSRLVKYPLLLREILRHT 277
Query: 700 DPETEKRDLENLTRALEALRAFMKRIDKASGAAQDRHDVKLLKQKILFKNEYVNMGLNDD 759
+ D ++L A+ ++ + I+ +G ++ R+ K+++L+ E L D
Sbjct: 278 --PNDNPDQQHLEEAINIIQGIVAEINTKTGESECRY----YKERLLYLEEGQKDSLIDS 331
Query: 760 KRKIKHEGLLSRKEITKNENGVTGDLQFYLLDNMLLFLKSKAVNKWNQHKVFQRPIPL 817
R + G L KN GV L +L +L+ ++ N+ ++++++PIP+
Sbjct: 332 SRVLCCHGEL------KNNRGV--KLHVFLFQEVLVITRAVTHNEQLCYQLYRQPIPV 381
>Hs7662086 [T] KOG3520 Predicted guanine nucleotide exchange factor
Length = 1522
Score = 79.7 bits (195), Expect = 3e-14
Identities = 71/304 (23%), Positives = 154/304 (50%), Gaps = 30/304 (9%)
Query: 515 DDDEEKSSWTSSVPEELWSSLTKREIKRQEAIYEVYSTEKKFVKSLEILRDTFMKKLAET 574
+ + + +W +V +++ + LT+REI RQE I E++ TE +++L +L F +++ +
Sbjct: 708 EPEPDAQNWQHTVGKDVVAGLTQREIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKE 767
Query: 575 NIIPADIRKNFIKHVFAHVNDIYSVNRRLLDALSERQKASPIVDGIGDILL-RFVPFFEP 633
N++P + + +F ++ ++ ++ +A+ + ++ PI+ I D++L RF
Sbjct: 768 NLMP----REELARLFPNLPELIEIHNSWCEAMKKLREEGPIIKEISDLMLARFDGPARE 823
Query: 634 FVMYVAS-----RPYAKYLIETQRSVNPYFARFDDDLMNSK--LRHGIDSFLSQGVSRPG 686
+ VA+ + A LI+T++ F F + + R + + + R
Sbjct: 824 ELQQVAAQFCSYQSIALELIKTKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLT 883
Query: 687 RYVLLVREIMKSTDPETEKRDLENLTRALEALRAFMKRIDKASGAAQDRHDVKLLKQKI- 745
+Y LL+ I+K T+ T + E L RA + R +K +++A ++RH ++ ++++
Sbjct: 884 KYPLLLESIIKHTEGGTSEH--EKLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLD 941
Query: 746 ---------LFKNEYVNMGLNDDKRKIKHEGLLSRKEITKNENGVTGDLQFYLLDNMLLF 796
E+ ++ L RK+ HEG L+ + I+K++ T DL LL+++L+
Sbjct: 942 ATALERASNPLAAEFKSLDLT--TRKMIHEGPLTWR-ISKDK---TLDLHVLLLEDLLVL 995
Query: 797 LKSK 800
L+ +
Sbjct: 996 LQKQ 999
>7302841 [T] KOG3520 Predicted guanine nucleotide exchange factor
Length = 2559
Score = 73.9 bits (180), Expect = 1e-12
Identities = 93/401 (23%), Positives = 165/401 (40%), Gaps = 52/401 (12%)
Query: 514 DDDDEEKSSWTSSVPEELWSSLTKREIKRQEAIYEVYSTEKKFVKSLEILRDTFMKKLAE 573
D+DD ++ W+S V E+ ++LT E KRQE I E+Y TE+ V++L++L F L E
Sbjct: 1511 DEDDVNEADWSSMVAAEVLAALTDAEKKRQEIINEIYQTERNHVRTLKLLDRLFFLPLYE 1570
Query: 574 TNIIPADIRKNFIKHVFAHVNDIYSVNRRLLDALSERQKASPIVDGIGDILLRFVPFFEP 633
+ ++ D + +I+ + L R + + +V+ IGD+L F+
Sbjct: 1571 SGLLSQDHLLLLFPPALLSLREIHGAFEQSLK--QRRIEHNHVVNTIGDLL---ADMFDG 1625
Query: 634 FVMYVASRPYAKYLIETQRSVNPYFARFDDDLMNSKL-----------RHGIDSFLSQGV 682
V A++ Q ++ + + D M KL R + L +
Sbjct: 1626 QSGVVLCEFAAQFCARQQIALEALKEKRNKDEMLQKLLKKSESHKACRRLELKDLLPTVL 1685
Query: 683 SRPGRYVLLVREIMKSTD---PETEKRDLENLTRALEALRAFMKRIDKASGAAQDRHDVK 739
R +Y LL + K T PE + E + RA+E+ + + +++A A+D H ++
Sbjct: 1686 QRLTKYPLLFENLYKVTVRLLPE-NTTEAEAIQRAVESSKRILVEVNQAVKTAEDAHKLQ 1744
Query: 740 LLKQKI----LFKNEYVNMGLNDDKRKIKHEGLLSRKEITKNENGVTGDLQFYLLDNMLL 795
+++K+ K E+ + L + + H+G L+ I KN + L L +NM++
Sbjct: 1745 NIQRKLDRSSYDKEEFKKLDLT--QHHLIHDGNLT---IKKNP---SVQLHGLLFENMIV 1796
Query: 796 FLKSKAVNKWNQHKVFQRPIPLPLLFAAPGEEMPSLKRHICGKPDSQGMVIYPDAIAGTN 855
L + K + + + PL I KP S M I D +
Sbjct: 1797 LLTKQ------DDKYYLKNLHTPL--------------SITNKPVSPIMSIDADTLIRQE 1836
Query: 856 PRNAISFTYYGAKNKYQVTLYAAQFAAMQTLLEKIKQEQAR 896
+ SF K + L A + +T + AR
Sbjct: 1837 AADKNSFFLIKMKTSQMLELRAPSSSECKTWFKHFSDVAAR 1877
>Hs4504797_2 [T] KOG4305 RhoGEF GTPase
Length = 500
Score = 73.9 bits (180), Expect = 1e-12
Identities = 72/291 (24%), Positives = 129/291 (43%), Gaps = 22/291 (7%)
Query: 531 LWSSLTKREIKRQEAIYEVYSTEKKFVKSLEILRDTFMKKLAETNIIPADIRKNFIKHVF 590
L LT E KRQ I+E+ TE+ +V L+++ + F K L E+ + + + + +F
Sbjct: 6 LLDMLTPTERKRQGYIHELIVTEENYVNDLQLVTEIFQKPLMESEL----LTEKEVAMIF 61
Query: 591 AHVNDIYSVNRRLLDALSERQKAS---PIVDGIGDILLRFVPFFEPFVMYVASRPYAKYL 647
+ ++ N +LL AL R+K S V IGDIL +P +P++ + + + L
Sbjct: 62 VNWKELIMCNIKLLKALRVRKKMSGEKMPVKMIGDILSAQLPHMQPYIRFCSRQLNGAAL 121
Query: 648 IETQRSVNPYFARFDDDLMNSKLRHG--IDSFLSQGVSRPGRYVLLVREIMKSTDPETEK 705
I+ + P F F L G + SF+ + + R RY L+++ I+++T PE
Sbjct: 122 IQQKTDEAPDFKEFVKRLEMDPRCKGMPLSSFILKPMQRVTRYPLIIKNILENT-PENHP 180
Query: 706 RDLENLTRALEALRAFMKRIDKASGAAQDRHDVKLLKQKILFKNEYVNMGLND-----DK 760
D +L ALE ++++ ++ ++ ++ + + + N
Sbjct: 181 -DHSHLKHALEKAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLSEQLVFNSVTNCLGP 239
Query: 761 RKIKHEGLLSRKEITKNENGVTGDLQFYLLDNMLLFLKSKAVNKWNQHKVF 811
RK H G L + + K G F D +LL +K + KVF
Sbjct: 240 RKFLHSGKLYKAKNNKELYG------FLFNDFLLLTQITKPLGSSGTDKVF 284
>Hs21361487 [T] KOG3523 Putative guanine nucleotide exchange factor TIM
Length = 871
Score = 71.6 bits (174), Expect = 7e-12
Identities = 71/297 (23%), Positives = 144/297 (47%), Gaps = 19/297 (6%)
Query: 520 KSSWT--SSVPEE-LWSSLTKREIKRQEAIYEVYSTEKKFVKSLEILRDTF--MKKLAET 574
+S+W+ S+V + L ++++ E KRQEAI+EV S+E ++ SLEIL F K+L++T
Sbjct: 415 RSTWSQLSAVKRKGLSQTVSQEERKRQEAIFEVISSEHSYLLSLEILIRMFKNSKELSDT 474
Query: 575 NIIPADIRKNFIKHVFAHVNDIYSVNRRLLDALSERQKASPIVDGIGDILLRF-VPFFEP 633
+ K H+F+++ D+ +++ L R + + +D I DI+ + F+P
Sbjct: 475 ------MTKTERHHLFSNITDVCEASKKFFIELEARHQNNIFIDDISDIVEKHTASTFDP 528
Query: 634 FVMYVASRPYAKYLIETQRSVNPYFARFDDDLMNSKLRHGID--SFLSQGVSRPGRYVLL 691
+V Y + Y + ++ + NP F + + + + SFL + R R LL
Sbjct: 529 YVKYCTNEVYQQRTLQKLLATNPSFKEVLSRIESHEDCRNLPMISFLILPMQRVTRLPLL 588
Query: 692 VREIMKSTDPETEKRDLENLTRALEALRAFMKRIDKASGAAQDRHDVKLLKQKILFKNEY 751
+ I + T ++ K E RAL+ + ++ ++ + + + + ++ FK +
Sbjct: 589 MDTICQKTPKDSPK--YEVCKRALKEVSKLVRLCNEGARKMERTEMMYTINSQLEFKIKP 646
Query: 752 VNMGLNDDKRKIKHEGLLSRKEITKNENGVTGDLQ--FYLLDNMLLFLKSKAVNKWN 806
+ ++ + +K L + E T + T Q F+L +++L+ K K+ +N
Sbjct: 647 FPL-VSSSRWLVKRGELTAYVEDTVLFSRRTSKQQVYFFLFNDVLIITKKKSEESYN 702
>CE25936 [T] KOG3523 Putative guanine nucleotide exchange factor TIM
Length = 1136
Score = 69.7 bits (169), Expect = 3e-11
Identities = 78/321 (24%), Positives = 152/321 (47%), Gaps = 26/321 (8%)
Query: 499 LKPNGGLKRNISMAIDDDDEEKSSWTSSVPEELWSSLTKR---EIK-RQEAIYEVYSTEK 554
L N ++R+ + + ++S W +PE + L ++ E K RQEA +EV ++E
Sbjct: 613 LTSNTSMRRDRLVGTSNFGSQRSLWCE-LPEVRAAGLLEKLDDECKLRQEAYFEVITSEA 671
Query: 555 KFVKSLEILRDTFM--KKLAETNIIPADIRKNFIKHVFAHVNDIYSVNRRLLDALSERQK 612
+++SL +L FM ++ + + + + KH+F+++ + + RLL L R +
Sbjct: 672 SYLRSLNVLITHFMASPQMLGSKSALSVLSDSDRKHLFSNIFAVRDCSERLLCDLETRLE 731
Query: 613 ASPIVDGIGDILL-RFVPFFEPFVMYVASRPYAKYLIETQRSVNPYFARFDDDLMNSKLR 671
+ I+D I DIL F FE ++ Y +++ Y + ++ NP F L +K
Sbjct: 732 ENLILDDICDILSDHFDKHFEVYIKYCSNQVYQDRTLRRLKTENPGFLSAVQRLEENKQC 791
Query: 672 HGID--SFLSQGVSRPGRYVLLVREIMK--STDPETEKRDLENLTRALEALRAFMKRIDK 727
G+D SFL + R RY LL+ I+ +T + K + LT + +R D
Sbjct: 792 QGLDMRSFLMLPMQRVTRYPLLLYAILDRITTTDDRYKTATDALTSSNRVVR------DC 845
Query: 728 ASGAAQDRHDVKLL--KQKILFKN-EYVNMGLNDDKRKIKHEGLLSRKEITKNENGVTG- 783
GA + +LL +++++K+ + + L + R + +G+L++ ++ N +
Sbjct: 846 NEGARRMERTEQLLDIDRRLIYKDADLKRIPLVSNSRYLVKKGVLTQLVERRSSNILQSR 905
Query: 784 ----DLQFYLLDNMLLFLKSK 800
L +L +M++ K K
Sbjct: 906 QKARTLHVFLFSDMIMITKKK 926
>CE19531 [T] KOG3523 Putative guanine nucleotide exchange factor TIM
Length = 648
Score = 69.7 bits (169), Expect = 3e-11
Identities = 78/321 (24%), Positives = 152/321 (47%), Gaps = 26/321 (8%)
Query: 499 LKPNGGLKRNISMAIDDDDEEKSSWTSSVPEELWSSLTKR---EIK-RQEAIYEVYSTEK 554
L N ++R+ + + ++S W +PE + L ++ E K RQEA +EV ++E
Sbjct: 125 LTSNTSMRRDRLVGTSNFGSQRSLWCE-LPEVRAAGLLEKLDDECKLRQEAYFEVITSEA 183
Query: 555 KFVKSLEILRDTFM--KKLAETNIIPADIRKNFIKHVFAHVNDIYSVNRRLLDALSERQK 612
+++SL +L FM ++ + + + + KH+F+++ + + RLL L R +
Sbjct: 184 SYLRSLNVLITHFMASPQMLGSKSALSVLSDSDRKHLFSNIFAVRDCSERLLCDLETRLE 243
Query: 613 ASPIVDGIGDILL-RFVPFFEPFVMYVASRPYAKYLIETQRSVNPYFARFDDDLMNSKLR 671
+ I+D I DIL F FE ++ Y +++ Y + ++ NP F L +K
Sbjct: 244 ENLILDDICDILSDHFDKHFEVYIKYCSNQVYQDRTLRRLKTENPGFLSAVQRLEENKQC 303
Query: 672 HGID--SFLSQGVSRPGRYVLLVREIMK--STDPETEKRDLENLTRALEALRAFMKRIDK 727
G+D SFL + R RY LL+ I+ +T + K + LT + +R D
Sbjct: 304 QGLDMRSFLMLPMQRVTRYPLLLYAILDRITTTDDRYKTATDALTSSNRVVR------DC 357
Query: 728 ASGAAQDRHDVKLL--KQKILFKN-EYVNMGLNDDKRKIKHEGLLSRKEITKNENGVTG- 783
GA + +LL +++++K+ + + L + R + +G+L++ ++ N +
Sbjct: 358 NEGARRMERTEQLLDIDRRLIYKDADLKRIPLVSNSRYLVKKGVLTQLVERRSSNILQSR 417
Query: 784 ----DLQFYLLDNMLLFLKSK 800
L +L +M++ K K
Sbjct: 418 QKARTLHVFLFSDMIMITKKK 438
>7298597 [T] KOG3520 Predicted guanine nucleotide exchange factor
Length = 1309
Score = 68.2 bits (165), Expect = 8e-11
Identities = 78/334 (23%), Positives = 149/334 (44%), Gaps = 40/334 (11%)
Query: 518 EEKSSWTSSVPEELWSSLTKREIKRQEAIYEVYSTEKKFVKSLEILRDTFMKKLAETNII 577
+E SWT +VP EL +L +IKRQE IYE TEK ++L +++ F++ L E +
Sbjct: 419 KEHDSWTPNVPRELLKTLKDLQIKRQEHIYEFIMTEKHHCQTLIVMQKVFVESL-ERHFP 477
Query: 578 PADIRKNFIKHVFAHVNDIYSVNRRLLDALSERQKASPIVDGIGDILLRFVPFFEPFVMY 637
++ +F + + ++ L L +Q+ +VD I DILL F + +
Sbjct: 478 SLNLNS-----MFPRLQQLTDLHTCFLRQLRLKQREQHMVDSIADILLDFFSLEQAQCLR 532
Query: 638 VASRPYAKYLIETQRSVN--------PYFARFDDDLMNSKL--RHGIDSFLSQGVSRPGR 687
+A Y ++ + +++ P FA + + + L + GI + R +
Sbjct: 533 LA---YGEFCANHRSALDQFKLCLTEPSFAEWYKHCLQNPLLKKKGIPECILFVTQRLTK 589
Query: 688 YVLLVREIMKSTDPETEKRDLENLTRALEALRAFMKRIDKASGAAQDRHDVKL------- 740
Y LL+ ++KS K + + L AL +++ + +D A A ++ + +L
Sbjct: 590 YPLLIEPLLKSA--RDNKLETDKLQHALNLVKSLLVDVD-ACVAEKELRERQLEIYGRVD 646
Query: 741 LKQKILFKNE---YVNMGLNDDKRKIKHEGLLSRKEITKNENGVTGDLQFYLLDNMLLFL 797
K ++KN+ +G+ + +R++K +GL + + V L L D +
Sbjct: 647 AKSFAIYKNKPFRKTELGV-ESRRRLKFDGLATLMQGRAKTQLV---LVVVLTDCLCFLS 702
Query: 798 KSKAVNKWN----QHKVFQRPIPLPLLFAAPGEE 827
++ NK++ +HK P+ L+ G E
Sbjct: 703 ENSGHNKYSFFTPEHKAGVVPLQKLLIREKAGTE 736
>Hs7662378_2 [T] KOG3523 Putative guanine nucleotide exchange factor TIM
Length = 490
Score = 66.6 bits (161), Expect = 2e-10
Identities = 60/247 (24%), Positives = 121/247 (48%), Gaps = 18/247 (7%)
Query: 531 LWSSLTKREIKRQEAIYEVYSTEKKFVKSLEILRDTF-MKKLAETNIIPADIRKNFIKHV 589
L +L+ +E + QE+++EV ++E +++SL +L DTF + + + P D +
Sbjct: 56 LLDTLSPQERRMQESLFEVVTSEASYLRSLRLLTDTFVLSQALRDTLTPRDHHT-----L 110
Query: 590 FAHVNDIYSVNRRLLDALSERQKASPIVDGIGDIL-LRFVPFFEPFVMYVASRPYAKYLI 648
F++V + V+ R L L R ++SP + + D++ V F +V YV ++ Y +
Sbjct: 111 FSNVQRVQGVSERFLATLLSRVRSSPHISDLCDVVHAHAVGPFSVYVDYVRNQQYQE--- 167
Query: 649 ETQRSVNPYFARFDDDLMNSKL-----RHGIDSFLSQGVSRPGRYVLLVREIMKSTDPET 703
ET + RF +L + R + SFL R R +L++ I++ T+ +
Sbjct: 168 ETYSRLMDTNVRFSAELRRLQSLPKCERLPLPSFLLLPFQRITRLRMLLQNILRQTEEGS 227
Query: 704 EKRDLENLTRALEALRAFMKRIDKASGAAQDRHDVKLLKQKILFKNEYVNMGLNDDKRKI 763
++ EN +AL A+ ++R G + ++ L Q++ F ++ + L R++
Sbjct: 228 SRQ--ENAQKALGAVSKIIERCSAEVGRMKQTEELIRLTQRLRF-HKVKALPLVSWSRRL 284
Query: 764 KHEGLLS 770
+ +G L+
Sbjct: 285 EFQGELT 291
>CE03899 [T] KOG4424 Predicted Rho/Rac guanine nucleotide exchange
factor/faciogenital dysplasia protein 3
Length = 665
Score = 65.9 bits (159), Expect = 4e-10
Identities = 61/280 (21%), Positives = 137/280 (48%), Gaps = 37/280 (13%)
Query: 525 SSVPEELWSSLTKREIKRQEAIYEVYSTEKKFVKSLEILRDTFMKKLAETNIIPADIRKN 584
S +P ++ + + ++ + + E+Y TE+ +VK+L I+ + F+++L N+ +K
Sbjct: 38 SYLPFDMSTLYANQPTEKIQILQEIYDTERTYVKALTIVDEIFIQQL---NLWCPKSKKC 94
Query: 585 FIKHVFAHVNDIYSVNRRLLDALSERQKASPIVDGIGDILLRFVPFFEPFVMYVASRPYA 644
F + +F ++ I ++ LL++L + I ++ +FVPF + + Y + P +
Sbjct: 95 F-RSMFGEISAICKTHQILLESLQCKP--------IAEVFTKFVPFLKLYTSYASHYPNS 145
Query: 645 KYLIETQRSVNPYFARF----DDDLMNSKLRHGIDSFLSQGVSRPGRYVLLVREIMKSTD 700
+ S N + +D ++ K + ++L + R RY++L++ +M +
Sbjct: 146 LKIFAKLMSRNDFRKALTKIEEDPRVDGK---KLQTYLIMPIQRIPRYIMLIQNLMNYS- 201
Query: 701 PETEKRDLENLTRALEALRAFMKRIDKASGAAQDRHDVKLLKQKILFKNEYVNMGLN--- 757
TEK D+ NL +AL ++ +I A ++ +LL+ ++ N GL+
Sbjct: 202 --TEKDDMTNLYKALSGMQGLSDQIQSCMTAYENGE--RLLQIQL-------NFGLDGHI 250
Query: 758 -DDKRKIKHEGLLSRKEITKNENGVTGDLQFYLLDNMLLF 796
+ R + EG+L ++E+ + N + +L +++LL+
Sbjct: 251 LEPGRVLLKEGMLYKRELNGSAN--YQETVVFLFNDILLY 288
>Hs4758358 [T] KOG4424 Predicted Rho/Rac guanine nucleotide exchange
factor/faciogenital dysplasia protein 3
Length = 961
Score = 65.1 bits (157), Expect = 7e-10
Identities = 76/303 (25%), Positives = 131/303 (43%), Gaps = 43/303 (14%)
Query: 514 DDDDEEKSSWTSSVPEELWSSLTKREIKRQEAIY----EVYSTEKKFVKSLEILRDTFMK 569
+DD+EE+ +P L E+ Q+ ++ E+ TEK +V L +L F
Sbjct: 342 EDDEEEEEEKDREIPVPLMERQESVELTVQQKVFHIANELLQTEKAYVSRLHLLDQVFCA 401
Query: 570 KLAET----NIIPADIRKNFIKHVFAHVNDIYSVNRR-LLDALSERQKASPIVDGIGDIL 624
+L E + PAD+ + +F+++ IY +++ LL L +R + IGDIL
Sbjct: 402 RLLEEARNRSSFPADV----VHGIFSNICSIYCFHQQFLLPELEKRMEEWDRYPRIGDIL 457
Query: 625 LRFVPFFEPFVMYVASRPYAKYLI------ETQRSVNPYFARFDDDLMNSKLRHGIDSFL 678
+ PF + + YV + A L+ TQ V + + ++ N L+H +
Sbjct: 458 QKLAPFLKMYGEYVKNFDRAVELVNTWTERSTQFKVIIHEVQKEEACGNLTLQH----HM 513
Query: 679 SQGVSRPGRYVLLVREIM-----KSTDPETEKRDLENLTRALEALRAFMKRIDKASGAAQ 733
+ V R RY LL+++ + S D + ++ LE + A E A ++++++
Sbjct: 514 LEPVQRIPRYELLLKDYLLKLPHGSPDSKDAQKSLELIATAAEHSNAAIRKMERMH---- 569
Query: 734 DRHDVKLLKQKILFKNEYVNMGLNDDKRKIKHEGLLSRKEITKNENGVTGDLQFYLLDNM 793
KLLK L E + + K H LS K NG T D L ++
Sbjct: 570 -----KLLKVYELLGGEEDIVSPTKELIKEGHILKLSAK------NGTTQDRYLILFNDR 618
Query: 794 LLF 796
LL+
Sbjct: 619 LLY 621
>Hs11128045_2 [T] KOG4305 RhoGEF GTPase
Length = 355
Score = 64.7 bits (156), Expect = 9e-10
Identities = 58/252 (23%), Positives = 118/252 (46%), Gaps = 16/252 (6%)
Query: 539 EIKRQEAIYEVYSTEKKFVKSLEILRDTFMKKLAETNIIPADIRKNFIKHVFAHVNDIYS 598
E KRQ I+E+ TE++++ L+++ + F K++AE+ + + + +F + ++
Sbjct: 14 ERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGF----LTEGEMALIFVNWKELIM 69
Query: 599 VNRRLLDALSERQKA---SPIVDGIGDILLRFVPFFEPFVMYVASRPYAKYLIETQRSVN 655
N +LL AL R+K V IGDIL + + ++ + + + L++ + +
Sbjct: 70 SNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQAYIRFCSCQLNGAALLQQKTDED 129
Query: 656 PYFARFDDDLMNSKLRHG--IDSFLSQGVSRPGRYVLLVREIMKSTDPETEKRDLENLTR 713
F F L + G + SFL + + R RY LL+R I+++T PE+ D +L
Sbjct: 130 TDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENT-PESH-ADHSSLKL 187
Query: 714 ALEALRAFMKRIDKASGAAQDRHDVKLLKQKILFKNEYVNMGLND-----DKRKIKHEGL 768
ALE ++++ ++ ++ ++ + + + N RK+ H G
Sbjct: 188 ALERAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLAEQLIFNSLTNCLGPRKLLHSGK 247
Query: 769 LSRKEITKNENG 780
L + + K +G
Sbjct: 248 LYKTKSNKELHG 259
>7295262 [T] KOG4424 Predicted Rho/Rac guanine nucleotide exchange
factor/faciogenital dysplasia protein 3
Length = 647
Score = 64.3 bits (155), Expect = 1e-09
Identities = 55/233 (23%), Positives = 111/233 (47%), Gaps = 21/233 (9%)
Query: 542 RQEAIYEVYSTEKKFVKSLEILRDTFMKKLAETNIIPADIRKNFIKHVFAHVNDIYSVNR 601
R++AI E+ S+EK +++ LE+L + F++ L E II D + + +F + I+++N
Sbjct: 71 RRQAIQEIISSEKSYLEQLELLMNFFVRPLKEQAII--DCSNHTL--LFGQIEMIHNLNG 126
Query: 602 RLLDALSERQKASPIVDGIGDILLRFVPFFEPFVMYVASRPYAKYLIETQRSVNPYFARF 661
L L ++ + L+ PFF+ + +Y A ++I+ S NP F +F
Sbjct: 127 EFLRELEAN------MENVAHAFLKMAPFFKLYSVYAFDYRGALFIIQDLISKNPVFRKF 180
Query: 662 -DDDLMNSKLRHGIDSFLSQGVSRPGRYVLLVREIMKSTDPETEKRDLENLTRALEALRA 720
+ +++ ++S + + R RY LL+ +++ T P D + L +++ + A
Sbjct: 181 LEQTESRPEVQRKLNSLMIVPIQRVPRYKLLLEQVLLYTSP--ADADYKLLKESVKEIEA 238
Query: 721 FMKRIDKASGAAQDRHDVKLLKQKILFKNEYVNMGLNDDK--RKIKHEGLLSR 771
I+ + ++ + I +N VN N K R++ EG+L +
Sbjct: 239 TASHINTCV------EEQEITQYLIHLQNSLVNRTPNIVKPSRRVIKEGVLQK 285
>Hs14670377 [T] KOG3520 Predicted guanine nucleotide exchange factor
Length = 1015
Score = 62.8 bits (151), Expect = 3e-09
Identities = 73/310 (23%), Positives = 137/310 (43%), Gaps = 34/310 (10%)
Query: 514 DDDDEEKSSWTSSVPEELWSSLTKREI-KRQEAIYEVYSTEKKFVKSLEILRDTFMKKLA 572
D + E SW+ +V + ++ KRE+ KRQ+ +YE+ TE V++L+I+ + + L
Sbjct: 74 DGHEFEAESWSLAV-DAAYAKKQKREVVKRQDVLYELMQTEVHHVRTLKIMLKVYSRALQ 132
Query: 573 ETNIIPADIRKNFIKHVFAHVNDIYSVNRRLLDALSERQKAS--------PIVDGIGDIL 624
E I +F +D+ + L L ER++ S ++ IGD+L
Sbjct: 133 E----ELQFSSKAIGRLFPCADDLLETHSHFLARLKERRQESLEEGSDRNYVIQKIGDLL 188
Query: 625 LRFVP------FFEPFVMYVASRPYAKYLIETQRSVNPYFARFDDDLMNSKL--RHGIDS 676
++ E + ++ + A + N F + N + R G+
Sbjct: 189 VQQFSGENGERMKEKYGVFCSGHNEAVSHYKLLLQQNKKFQNLIKKIGNFSIVRRLGVQE 248
Query: 677 FLSQGVSRPGRYVLLVREIMKSTDPETEKRDLENLTRALEALRAFMKRID-KASGAAQDR 735
+ R +Y +LV I+++T+ TE D E+LT+AL ++ + ++D K S + +
Sbjct: 249 CILLVTQRITKYPVLVERIIQNTEAGTE--DYEDLTQALNLIKDIISQVDAKVSECEKGQ 306
Query: 736 HDVKLLKQKILFKNEYVNMGLNDDK-----RKIKHEGLLSRKEITKNENGVTGDLQFYLL 790
++ + L + + GL K R++ EG+L K +G D+ LL
Sbjct: 307 RLREIAGKMDLKSSSKLKNGLTFRKEDMLQRQLHLEGML----CWKTTSGRLKDILAILL 362
Query: 791 DNMLLFLKSK 800
++LL L+ K
Sbjct: 363 TDVLLLLQEK 372
>HsM19923376 [T] KOG3520 Predicted guanine nucleotide exchange factor
Length = 2817
Score = 61.2 bits (147), Expect = 1e-08
Identities = 68/311 (21%), Positives = 135/311 (42%), Gaps = 34/311 (10%)
Query: 513 IDDDDEEKSSWTSSVPEELWSSLTKREIKRQEAIYEVYSTEKKFVKSLEILRDTFMKKLA 572
I+ E SW+ + + K +KRQE IYE+ TE V++L+I+ + + +
Sbjct: 1970 IESKQLEAESWSRIIDSKFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMM 2029
Query: 573 ETNIIPADIRKNFIKHVFAHVNDIYSVNRRLLDALSERQKASPI--------VDGIGDIL 624
+ + ++ +F ++++ S++ + + ER+K S + + IGD+L
Sbjct: 2030 ADLL----FEQQMVEKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVL 2085
Query: 625 LRFVPFFEPFVMYVASRPYAKYLIETQRSVNPY---------FARFDDDLMNSKL--RHG 673
V F + Y K+ + +SVN + F F M+S + R G
Sbjct: 2086 ---VNQFSGENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLG 2142
Query: 674 IDSFLSQGVSRPGRYVLLVREIMKST-DPETEKRDL-ENLTRALEALRAFMKRIDKASGA 731
I + R +Y +L + I++ T D E E+ DL ++L+ + + A ++
Sbjct: 2143 IPECILLVTQRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKK 2202
Query: 732 AQDRHDVKLLKQKILFKNEYVNMGLNDD--KRKIKHEGLLSRKEITKNENGVTGDLQFYL 789
+ K + + + M +D ++K+ +G + KN G ++Q L
Sbjct: 2203 VRLNEIYTKTDSKSIMRMKSGQMFAKEDLKRKKLVRDGSV----FLKNAAGRLKEVQAVL 2258
Query: 790 LDNMLLFLKSK 800
L ++L+FL+ K
Sbjct: 2259 LTDILVFLQEK 2269
>HsM17933492 [T] KOG3520 Predicted guanine nucleotide exchange factor
Length = 2813
Score = 61.2 bits (147), Expect = 1e-08
Identities = 68/311 (21%), Positives = 135/311 (42%), Gaps = 34/311 (10%)
Query: 513 IDDDDEEKSSWTSSVPEELWSSLTKREIKRQEAIYEVYSTEKKFVKSLEILRDTFMKKLA 572
I+ E SW+ + + K +KRQE IYE+ TE V++L+I+ + + +
Sbjct: 1966 IESKQLEAESWSRIIDSKFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMM 2025
Query: 573 ETNIIPADIRKNFIKHVFAHVNDIYSVNRRLLDALSERQKASPI--------VDGIGDIL 624
+ + ++ +F ++++ S++ + + ER+K S + + IGD+L
Sbjct: 2026 ADLL----FEQQMVEKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVL 2081
Query: 625 LRFVPFFEPFVMYVASRPYAKYLIETQRSVNPY---------FARFDDDLMNSKL--RHG 673
V F + Y K+ + +SVN + F F M+S + R G
Sbjct: 2082 ---VNQFSGENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLG 2138
Query: 674 IDSFLSQGVSRPGRYVLLVREIMKST-DPETEKRDL-ENLTRALEALRAFMKRIDKASGA 731
I + R +Y +L + I++ T D E E+ DL ++L+ + + A ++
Sbjct: 2139 IPECILLVTQRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKK 2198
Query: 732 AQDRHDVKLLKQKILFKNEYVNMGLNDD--KRKIKHEGLLSRKEITKNENGVTGDLQFYL 789
+ K + + + M +D ++K+ +G + KN G ++Q L
Sbjct: 2199 VRLNEIYTKTDSKSIMRMKSGQMFAKEDLKRKKLVRDGSV----FLKNAAGRLKEVQAVL 2254
Query: 790 LDNMLLFLKSK 800
L ++L+FL+ K
Sbjct: 2255 LTDILVFLQEK 2265
>Hs21493031 [T] KOG3520 Predicted guanine nucleotide exchange factor
Length = 1058
Score = 61.2 bits (147), Expect = 1e-08
Identities = 68/311 (21%), Positives = 135/311 (42%), Gaps = 34/311 (10%)
Query: 513 IDDDDEEKSSWTSSVPEELWSSLTKREIKRQEAIYEVYSTEKKFVKSLEILRDTFMKKLA 572
I+ E SW+ + + K +KRQE IYE+ TE V++L+I+ + + +
Sbjct: 211 IESKQLEAESWSRIIDSKFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMM 270
Query: 573 ETNIIPADIRKNFIKHVFAHVNDIYSVNRRLLDALSERQKASPI--------VDGIGDIL 624
+ + ++ +F ++++ S++ + + ER+K S + + IGD+L
Sbjct: 271 ADLL----FEQQMVEKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVL 326
Query: 625 LRFVPFFEPFVMYVASRPYAKYLIETQRSVNPY---------FARFDDDLMNSKL--RHG 673
V F + Y K+ + +SVN + F F M+S + R G
Sbjct: 327 ---VNQFSGENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLG 383
Query: 674 IDSFLSQGVSRPGRYVLLVREIMKST-DPETEKRDL-ENLTRALEALRAFMKRIDKASGA 731
I + R +Y +L + I++ T D E E+ DL ++L+ + + A ++
Sbjct: 384 IPECILLVTQRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKK 443
Query: 732 AQDRHDVKLLKQKILFKNEYVNMGLNDD--KRKIKHEGLLSRKEITKNENGVTGDLQFYL 789
+ K + + + M +D ++K+ +G + KN G ++Q L
Sbjct: 444 VRLNEIYTKTDSKSIMRMKSGQMFAKEDLKRKKLVRDGSV----FLKNAAGRLKEVQAVL 499
Query: 790 LDNMLLFLKSK 800
L ++L+FL+ K
Sbjct: 500 LTDILVFLQEK 510
>Hs21493029 [T] KOG3520 Predicted guanine nucleotide exchange factor
Length = 2813
Score = 61.2 bits (147), Expect = 1e-08
Identities = 68/311 (21%), Positives = 135/311 (42%), Gaps = 34/311 (10%)
Query: 513 IDDDDEEKSSWTSSVPEELWSSLTKREIKRQEAIYEVYSTEKKFVKSLEILRDTFMKKLA 572
I+ E SW+ + + K +KRQE IYE+ TE V++L+I+ + + +
Sbjct: 1966 IESKQLEAESWSRIIDSKFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMM 2025
Query: 573 ETNIIPADIRKNFIKHVFAHVNDIYSVNRRLLDALSERQKASPI--------VDGIGDIL 624
+ + ++ +F ++++ S++ + + ER+K S + + IGD+L
Sbjct: 2026 ADLL----FEQQMVEKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVL 2081
Query: 625 LRFVPFFEPFVMYVASRPYAKYLIETQRSVNPY---------FARFDDDLMNSKL--RHG 673
V F + Y K+ + +SVN + F F M+S + R G
Sbjct: 2082 ---VNQFSGENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLG 2138
Query: 674 IDSFLSQGVSRPGRYVLLVREIMKST-DPETEKRDL-ENLTRALEALRAFMKRIDKASGA 731
I + R +Y +L + I++ T D E E+ DL ++L+ + + A ++
Sbjct: 2139 IPECILLVTQRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKK 2198
Query: 732 AQDRHDVKLLKQKILFKNEYVNMGLNDD--KRKIKHEGLLSRKEITKNENGVTGDLQFYL 789
+ K + + + M +D ++K+ +G + KN G ++Q L
Sbjct: 2199 VRLNEIYTKTDSKSIMRMKSGQMFAKEDLKRKKLVRDGSV----FLKNAAGRLKEVQAVL 2254
Query: 790 LDNMLLFLKSK 800
L ++L+FL+ K
Sbjct: 2255 LTDILVFLQEK 2265
>Hs21493026 [T] KOG3520 Predicted guanine nucleotide exchange factor
Length = 2817
Score = 61.2 bits (147), Expect = 1e-08
Identities = 68/311 (21%), Positives = 135/311 (42%), Gaps = 34/311 (10%)
Query: 513 IDDDDEEKSSWTSSVPEELWSSLTKREIKRQEAIYEVYSTEKKFVKSLEILRDTFMKKLA 572
I+ E SW+ + + K +KRQE IYE+ TE V++L+I+ + + +
Sbjct: 1970 IESKQLEAESWSRIIDSKFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMM 2029
Query: 573 ETNIIPADIRKNFIKHVFAHVNDIYSVNRRLLDALSERQKASPI--------VDGIGDIL 624
+ + ++ +F ++++ S++ + + ER+K S + + IGD+L
Sbjct: 2030 ADLL----FEQQMVEKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVL 2085
Query: 625 LRFVPFFEPFVMYVASRPYAKYLIETQRSVNPY---------FARFDDDLMNSKL--RHG 673
V F + Y K+ + +SVN + F F M+S + R G
Sbjct: 2086 ---VNQFSGENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLG 2142
Query: 674 IDSFLSQGVSRPGRYVLLVREIMKST-DPETEKRDL-ENLTRALEALRAFMKRIDKASGA 731
I + R +Y +L + I++ T D E E+ DL ++L+ + + A ++
Sbjct: 2143 IPECILLVTQRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKK 2202
Query: 732 AQDRHDVKLLKQKILFKNEYVNMGLNDD--KRKIKHEGLLSRKEITKNENGVTGDLQFYL 789
+ K + + + M +D ++K+ +G + KN G ++Q L
Sbjct: 2203 VRLNEIYTKTDSKSIMRMKSGQMFAKEDLKRKKLVRDGSV----FLKNAAGRLKEVQAVL 2258
Query: 790 LDNMLLFLKSK 800
L ++L+FL+ K
Sbjct: 2259 LTDILVFLQEK 2269
>Hs22046517 [T] KOG3523 Putative guanine nucleotide exchange factor TIM
Length = 802
Score = 60.1 bits (144), Expect = 2e-08
Identities = 52/223 (23%), Positives = 108/223 (48%), Gaps = 13/223 (5%)
Query: 533 SSLTKREIKRQEAIYEVYSTEKKFVKSLEILRDTFMKKLAETNIIPADIRKNFIKHVFAH 592
++L+ R+ K QEA +E+ ++E ++ SL + F+ + + A ++ +F+
Sbjct: 368 ATLSLRDCKLQEAKFELITSEASYIHSLSVAVGHFLGSAELSECLGAQDKQ----WLFSK 423
Query: 593 VNDIYSVNRRLLDALSERQKASPIVDGIGDILLRFVPFFEP-FVMYVASRPYAKYLIETQ 651
+ ++ S + R L L +R +A + + D++L P F ++ YV ++ Y + +
Sbjct: 424 LPEVKSTSERFLQDLEQRLEADVLRFSVCDVVLDHCPAFRRVYLPYVTNQAYQERTYQRL 483
Query: 652 RSVNPYF----ARFDDDLMNSKLRHGIDSFLSQGVSRPGRYVLLVREIMKSTDPETEKRD 707
NP F AR ++ + +L + SFL R R +LV I+K T +E D
Sbjct: 484 LLENPRFPGILARLEESPVCQRLP--LTSFLILPFQRITRLKMLVENILKRTAQGSEDED 541
Query: 708 LENLTRALEALRAFMKRIDKASGAAQDRHDVKLLKQKILFKNE 750
+ T+A AL+ ++ + + + + ++ L +KI F+ +
Sbjct: 542 M--ATKAFNALKELVQECNASVQSMKRTEELIHLSKKIHFEGK 582
>Hs20537850 [T] KOG3523 Putative guanine nucleotide exchange factor TIM
Length = 710
Score = 60.1 bits (144), Expect = 2e-08
Identities = 48/176 (27%), Positives = 86/176 (48%), Gaps = 11/176 (6%)
Query: 535 LTKREIKRQEAIYEVYSTEKKFVKSLEILRDTFMKKLAETNIIPADIRKNFIKHVFAHVN 594
L EIK QEA++E+ ++E + KSL +L FM E I + + +F++V
Sbjct: 267 LQPEEIKLQEAMFELVTSEASYYKSLNLLVSHFM----ENERIRKILHPSEAHILFSNVL 322
Query: 595 DIYSVNRRLLDALSERQKASPIVDGIGDILLRF-VPFFEPFVMYVASRPYA----KYLIE 649
D+ +V+ R L L R + + ++ + DI+ R+ F ++ YV+++ Y K L++
Sbjct: 323 DVLAVSERFLLELEHRMEENIVISDVCDIVYRYAADHFSVYITYVSNQTYQERTYKQLLQ 382
Query: 650 TQRSVNPYFARFDDDLMNSKLRHGIDSFLSQGVSRPGRYVLLVREIMKSTDPETEK 705
+ + A+ + D L SFL R R LLV+ I+K + +E+
Sbjct: 383 EKAAFRELIAQLELDPKCRGL--PFSSFLILPFQRITRLKLLVQNILKRVEERSER 436
>Hs15011981 [T] KOG3519 Invasion-inducing protein TIAM1/CDC24 and related
RhoGEF GTPases
Length = 670
Score = 58.2 bits (139), Expect = 8e-08
Identities = 56/292 (19%), Positives = 128/292 (43%), Gaps = 15/292 (5%)
Query: 516 DDEEKSSWTSSVPEELWSSLTKREIKRQEAIYEVYSTEKKFVKSLEILRDTFMKKLAETN 575
DD+ + S + + + ++ R I E+ STE+ ++K L + + ++++ +
Sbjct: 259 DDDAPLAGNSGAEDGGAEAQSSKDQMRTNVINEILSTERDYIKHLRDICEGYVRQCRKR- 317
Query: 576 IIPADI-RKNFIKHVFAHVNDIYSVNRRLLDALSER-QKASPIVDGIGDILLRFVPFFEP 633
AD+ + ++ +F ++ DIY + + AL +R + P + +G L F+
Sbjct: 318 ---ADMFSEEQLRTIFGNIEDIYRCQKAFVKALEQRFNRERPHLSELGACFLEHQADFQI 374
Query: 634 FVMYVASRPYAKYLIETQRSVNPYFARFDD-DLMNSKLRHGIDSFLSQGVSRPGRYVLLV 692
+ Y + P A + ++ Y F+ L+ + +D FL V + +Y L +
Sbjct: 375 YSEYCNNHPNACVELSRLTKLSKYVYFFEACRLLQKMIDISLDGFLLTPVQKICKYPLQL 434
Query: 693 REIMKSTDPETEKRDLENLTRALEALRAFMKRIDKASGAAQDRHDVKLLKQKILFKNEYV 752
E++K T P + RD +++ AL A++ + I++ ++ + + I ++
Sbjct: 435 AELLKYTHP--QHRDFKDVEAALHAMKNVAQLINERKRRLENIDKIAQWQSSI---EDWE 489
Query: 753 NMGLNDDKRKIKHEGLLSRKEITKNENGVTGDLQFYLLDNMLLFLKSKAVNK 804
L ++ + G L+R + F+L D+ L++ K + +
Sbjct: 490 GEDLLVRSSELIYSGELTR---VTQPQAKSQQRMFFLFDHQLIYCKKDLLRR 538
>Hs15011979 [T] KOG3519 Invasion-inducing protein TIAM1/CDC24 and related
RhoGEF GTPases
Length = 690
Score = 58.2 bits (139), Expect = 8e-08
Identities = 56/292 (19%), Positives = 128/292 (43%), Gaps = 15/292 (5%)
Query: 516 DDEEKSSWTSSVPEELWSSLTKREIKRQEAIYEVYSTEKKFVKSLEILRDTFMKKLAETN 575
DD+ + S + + + ++ R I E+ STE+ ++K L + + ++++ +
Sbjct: 259 DDDAPLAGNSGAEDGGAEAQSSKDQMRTNVINEILSTERDYIKHLRDICEGYVRQCRKR- 317
Query: 576 IIPADI-RKNFIKHVFAHVNDIYSVNRRLLDALSER-QKASPIVDGIGDILLRFVPFFEP 633
AD+ + ++ +F ++ DIY + + AL +R + P + +G L F+
Sbjct: 318 ---ADMFSEEQLRTIFGNIEDIYRCQKAFVKALEQRFNRERPHLSELGACFLEHQADFQI 374
Query: 634 FVMYVASRPYAKYLIETQRSVNPYFARFDD-DLMNSKLRHGIDSFLSQGVSRPGRYVLLV 692
+ Y + P A + ++ Y F+ L+ + +D FL V + +Y L +
Sbjct: 375 YSEYCNNHPNACVELSRLTKLSKYVYFFEACRLLQKMIDISLDGFLLTPVQKICKYPLQL 434
Query: 693 REIMKSTDPETEKRDLENLTRALEALRAFMKRIDKASGAAQDRHDVKLLKQKILFKNEYV 752
E++K T P + RD +++ AL A++ + I++ ++ + + I ++
Sbjct: 435 AELLKYTHP--QHRDFKDVEAALHAMKNVAQLINERKRRLENIDKIAQWQSSI---EDWE 489
Query: 753 NMGLNDDKRKIKHEGLLSRKEITKNENGVTGDLQFYLLDNMLLFLKSKAVNK 804
L ++ + G L+R + F+L D+ L++ K + +
Sbjct: 490 GEDLLVRSSELIYSGELTR---VTQPQAKSQQRMFFLFDHQLIYCKKDLLRR 538
>Hs15011974 [T] KOG3520 Predicted guanine nucleotide exchange factor
Length = 958
Score = 58.2 bits (139), Expect = 8e-08
Identities = 68/313 (21%), Positives = 133/313 (41%), Gaps = 38/313 (12%)
Query: 513 IDDDDEEKSSWTSSVPEELWSSLTKREIKRQEAIYEVYSTEKKFVKSLEILRDTFMKKLA 572
+D+ D SW+ +V K +K+Q+ IYE+ TE V++L+I+ F +
Sbjct: 179 MDEKDFAADSWSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTGML 238
Query: 573 ETNIIPADIRKNFIKHVFAHVNDIYSVNRRLLDALSERQKASP--------IVDGIGDIL 624
E + ++ +F V+++ ++ R L L ER++ + ++ +GD+L
Sbjct: 239 E----ELHLEPGVVQGLFPCVDELSDIHTRFLSQLLERRRQALCPGSTRNFVIHRLGDLL 294
Query: 625 LRFVPFFEPFVMYVASRPYAKYLIETQRSVNPYFARFDDDLMNSKL-----------RHG 673
+ F P + + Y+++ +++ Y + D + RHG
Sbjct: 295 IS--QFSGPSAEQMC-KTYSEFCSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHG 351
Query: 674 IDSFLSQGVSRPGRYVLLVREIMKSTDPETEKRDLENLTRALEALRAFMKRIDKASGAAQ 733
+ + R +Y LL+ I++ + E+R ++LT AL ++ + +D+ G Q
Sbjct: 352 VQECILLVTQRITKYPLLISRILQHSHGIEEER--QDLTTALGLVKELLSNVDE--GIYQ 407
Query: 734 DRHDVKLLKQKILFKNEYVNMGLNDDKRKIKHEGLLSRKEI------TKNENGVTGDLQF 787
+L Q+I + + K E LL RK I K G D+
Sbjct: 408 LEKGARL--QEIYNRMDPRAQTPVPGKGPFGREELLRRKLIHDGCLLWKTATGRFKDVLV 465
Query: 788 YLLDNMLLFLKSK 800
L+ ++L+FL+ K
Sbjct: 466 LLMTDVLVFLQEK 478
>CE29438 [T] KOG3522 Predicted guanine nucleotide exchange factor
Length = 826
Score = 58.2 bits (139), Expect = 8e-08
Identities = 59/257 (22%), Positives = 112/257 (42%), Gaps = 30/257 (11%)
Query: 531 LWSSLTKREIKRQEAIY-----EVYSTEKKFVKSLEILRDTFMKKLA---ETNIIPADIR 582
LW ++ ++R ++ E+ TEK FV+ LE L +M+ L E +I A +
Sbjct: 96 LWKKRSRASLRRHYSVRHLAARELLDTEKSFVEGLEFLVTKYMRPLRQPLECTLIEASL- 154
Query: 583 KNFIKHVFAHVNDIYSVNRRLLDALSERQKASPIVDGIGDILLRFVP---FFEPFVMYVA 639
+ +F + +I + ++ LL LS+R +GD+LL E ++ +V
Sbjct: 155 ---VDKIFYRIPEILAHHQVLLTTLSQRIDQWHKDAILGDVLLAHFSKQSMIETYISFVD 211
Query: 640 SRPYAKYLIETQRSVNPYFARFDDDLMNSKLRHGIDSFLSQGVSRPGRYVLLVREIMKST 699
+ +AK I R + + ++ + + +DS L + R RY L+V++++K T
Sbjct: 212 NFKFAKASIIQARQKHAFEKYYNRCCRDHPNKLDLDSLLISPIQRVPRYELIVKQMLKHT 271
Query: 700 DPETEKRDLENLTRALEALRAFMKRIDKASGAAQ-------------DRHDVKLLKQKIL 746
E E D E L RA + I++ ++ D D + K + L
Sbjct: 272 PVEHE--DRERLLRAQRHIHCLAVAINQHKDGSEQMEQRLREIEAIVDGLDDLVTKDRTL 329
Query: 747 FKNEYVNMGLNDDKRKI 763
+++ + + D +R I
Sbjct: 330 LRHDIITLKGTDRERCI 346
>CE27826 [T] KOG2996 Rho guanine nucleotide exchange factor VAV3
Length = 935
Score = 58.2 bits (139), Expect = 8e-08
Identities = 73/327 (22%), Positives = 140/327 (42%), Gaps = 28/327 (8%)
Query: 498 NLKPNGGLKRNISMAIDDDDEEKSSWTSSVPEELWSSLTKREI------KRQEAIYEVYS 551
N+ PN + I+ A D ++++ + S+ + ++ KR I E+Y
Sbjct: 160 NVDPNRTIYGPITSA-DPEEQQSEQLYDRIVTNRKPSMNENDLQNTPTLKRNRCIRELYD 218
Query: 552 TEKKFV-KSLEILRDTFMKKL------AETNIIPADIRKNFIKHVFAHVNDIYSVNRRLL 604
TEK +V ++L + TF + L ++ NII +I + + H + Y V L
Sbjct: 219 TEKNYVAQALVTIIKTFYEPLKGIIPTSDYNIIFGNIEEINVLHTALLADLEYPVKVAL- 277
Query: 605 DALSERQKASPI------VDGIGDILLRFVPFFEPFVMYVASRPYAKYLIETQRSVNPYF 658
LS+ PI IG++ +++ F + Y ++ P ++ L N +
Sbjct: 278 -GLSDATPPRPISLNECVPQTIGEVFIKYRDQFLAYGKYCSNLPDSRKLSNELLKTNEFI 336
Query: 659 ARFDDDL-MNSKLRHGIDSFLSQGVSRPGRYVLLVREIMKSTDPETEKRDLENLTRALEA 717
+R ++L + G++ L R +Y LL++E+ K TD D ++L A+E
Sbjct: 337 SRNINELTAQGNCKFGMNDLLCVPFQRLTKYPLLLKELQKKTD--LASPDRKSLEEAVEV 394
Query: 718 LRAFMKRIDKASGAAQDRHDVKLLKQKILFKNEYVNMGLNDDKRKIKHEGLLSRKEITKN 777
+ I++ S + ++Q I + +N+ L+D R + +G + E T
Sbjct: 395 MEDVCNYINEESRDTNAIKVIDEIEQSITDLSMPLNVKLHDYGR-VNLDGEVKMAESTLT 453
Query: 778 ENGVTGDLQFYLLDNMLLFLKSKAVNK 804
+ G +L D +++ KA NK
Sbjct: 454 QAGKPKQRYIFLFDKVIVV--CKAANK 478
>YAL041w [T] KOG3519 Invasion-inducing protein TIAM1/CDC24 and related
RhoGEF GTPases
Length = 854
Score = 57.4 bits (137), Expect = 1e-07
Identities = 52/215 (24%), Positives = 104/215 (48%), Gaps = 19/215 (8%)
Query: 536 TKREIKRQEAIYEVYSTEKKFVKSLEILRDTFMKKLAETNIIPADIRKNFIKHVFAHVND 595
+K+ + + I E +TE+K+V LEIL D + ++L ++N+I ++ + +F ++ D
Sbjct: 273 SKKHNEYVKIIKEFVATERKYVHDLEIL-DKYRQQLLDSNLITSEE----LYMLFPNLGD 327
Query: 596 IYSVNRRLLDALSERQKASPIVDGIGDILLRFVPFFEPFVMY-VASRPYAKYLIETQRSV 654
RR L +L P IG + + FF+ + + + ++L T +
Sbjct: 328 AIDFQRRFLISLEINALVEPSKQRIGALFMHSKHFFKLYEPWSIGQNAAIEFLSSTLHKM 387
Query: 655 NPYFARFDDD---LMNSKLRHGIDSFLSQGVSRPGRYVLLVREIMKSTDPETEKRDLENL 711
R D+ ++N+KL + SFL + V R RY LLV+E++ + + ++LE
Sbjct: 388 -----RVDESQRFIINNKLE--LQSFLYKPVQRLCRYPLLVKELLAESSDDNNTKELE-- 438
Query: 712 TRALEALRAFMKRIDKASGAAQDRHDVKLLKQKIL 746
AL+ + + I++ ++ VK L +++
Sbjct: 439 -AALDISKNIARSINENQRRTENHQVVKKLYGRVV 472
>YLR425w [T] KOG4305 RhoGEF GTPase
Length = 1307
Score = 57.0 bits (136), Expect = 2e-07
Identities = 88/400 (22%), Positives = 164/400 (41%), Gaps = 60/400 (15%)
Query: 461 VNGVFTLLAECYSPT-----CTRNRLCYSISCPKRLEQQARLNLKPNGGLKRNISMAIDD 515
+ GVFT L CYS T + +CYS C R +K + + +++ +
Sbjct: 391 ITGVFTELLPCYSFIDNTYGSTNSLICYSNVCTHGQSSGFRKEIKLSEIINKSVGL---- 446
Query: 516 DDEEKSSWTSS---VPEELWSSLTKREIKRQEAIYEVYSTEKKFVKSLEILRDTFMKKLA 572
WT P++L + + RE++RQ I+++ E++ + + + K+
Sbjct: 447 -------WTEYWHLTPDDL-AEINPREVQRQSFIFDLIILEERSLNMATAAVEIYGKRFD 498
Query: 573 ETNIIPADIRKNFIKHVFAHVNDIYSVNRRLLDALSERQKA-SPIVDGIGDILLRFVPFF 631
++ + K +F + +++ LL + + K +DG+G I ++
Sbjct: 499 KSLLPDEPEFKALAFDIFEPLIQLHT--EFLLTPIFWKLKTRGKFIDGVGKIYSKWCGEA 556
Query: 632 EP-FVMYVASRPYAKYLIETQRSVNPYFARFDDDLMNS------KLRHGIDSFLSQGVSR 684
+ ++ Y + +I ++ F + ++ NS K+ H + F S
Sbjct: 557 KNIYLNYAKAMATVHEIIMWEKKNKTKFVTWLKEIDNSVEITRSKMYHDVIFFGGFFKSL 616
Query: 685 PGRYVLLVREIMKSTDPETEKRDLENLTRALEALRAFMKRIDKASGAAQD-RHDVKLLKQ 743
V L R I+K+TDP E D E L ++ + +++ G A D R V+ KQ
Sbjct: 617 QNMPVTL-RSILKNTDPSME--DYEYLKIVIKEVEKLNFEVNQVHGLAIDHRKLVRFSKQ 673
Query: 744 KILFKNE-----YVNMG----LNDD--------------KRKIKHEGLLSRKEITKNENG 780
+L N YVN+G NDD +RK+ G + +K +
Sbjct: 674 LVLSTNSSNATSYVNVGGSTNANDDDAIQDKLALGLTYPERKLVLSGTVYKKRDLWLD-- 731
Query: 781 VTGDLQFYLLDNMLLFLKSKAVNKWNQHKVFQRPIPLPLL 820
+ LLDN LL + + + ++K+ +RPIP+ L
Sbjct: 732 -PTPVYIALLDNCLLITEEISKGETQKYKLIERPIPIDYL 770
>Hs4504335 [T] KOG4240 Multidomain protein contains SPEC repeats PH SH3 and
separate rac-specific and rho-specific guanine nucleotide
exchange factor domains
Length = 1663
Score = 57.0 bits (136), Expect = 2e-07
Identities = 60/241 (24%), Positives = 109/241 (44%), Gaps = 21/241 (8%)
Query: 491 LEQQARLNLKPNGGLKRNISMAIDDDDEEK-SSWTSSVPEELWSSLTKREIKRQEAIYEV 549
LE+ +N + N L+ +I A D E K V EE S K+E + E+
Sbjct: 1234 LEKALGVNTEDNKDLELDIIPASLSDREVKLRDANHEVNEEKRKSARKKEF----IMAEL 1289
Query: 550 YSTEKKFVKSLEILRDTFMKKLAE--TNIIPADIRKNFIKHVFAHVNDIYSVNRRLLDAL 607
TEK +V+ L +T++ ++ I P + K I +F ++ +IY + + L
Sbjct: 1290 LQTEKAYVRDLHECLETYLWEMTSGVEEIPPGILNKEHI--IFGNIQEIYDFHNNIF--L 1345
Query: 608 SERQKASPIVDGIGDILLRFVPFFEPFVMYVASRPYAKYLIETQRSVNPYFARFDDDLMN 667
E +K + + +G + + F+ +V Y ++P + LI FD+
Sbjct: 1346 KELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSNQLILEHAGTF-----FDEIQQR 1400
Query: 668 SKLRHGIDSFLSQGVSRPGRYVLLVREIMKSTDPETEKRDLENLTRALEALRAFMKRIDK 727
L + I S+L + V R +Y LL++E++ T E K +L++ LE + + K+ +
Sbjct: 1401 HGLANSISSYLIKPVQRITKYQLLLKELL--TCCEEGKGELKD---GLEVMLSVPKKAND 1455
Query: 728 A 728
A
Sbjct: 1456 A 1456
>Hs5902140_1 [T] KOG0689 Guanine nucleotide exchange factor for Rho and Rac
GTPases
Length = 985
Score = 57.0 bits (136), Expect = 2e-07
Identities = 48/185 (25%), Positives = 91/185 (48%), Gaps = 16/185 (8%)
Query: 542 RQEAIYEVYSTEKKFVKSLEILRDTFMKKLAETNIIPADIRKNFIKHVFAHVNDIYSVNR 601
R + E+ TEK +VK L I+ + FMK++ E +P D+R K VF +++ IY ++
Sbjct: 233 RMFVLNELVQTEKDYVKDLGIVVEGFMKRIEEKG-VPEDMRGK-DKIVFGNIHQIYDWHK 290
Query: 602 RLLDALSERQKASPIVDGIGDILLRFVPFFEPFVMYVASRPYAKYLIETQRSVNPYFARF 661
L+E +K D + + ++ +V Y ++P ++Y+ V Y A F
Sbjct: 291 DFF--LAELEKCIQEQDRLAQLFIKHERKLHIYVWYCQNKPRSEYI------VAEYDAYF 342
Query: 662 DDDLMNSKLRHGIDSFLSQGVSRPGRYVLLVREIMKSTDPETEKRDLE--NLTRALEALR 719
++ R + FL + + R +Y LL+++ ++ +EK LE ++ +A+E +
Sbjct: 343 EEVKQEINQRLTLSDFLIKPIQRITKYQLLLKDFLR----YSEKAGLECSDIEKAVELMC 398
Query: 720 AFMKR 724
KR
Sbjct: 399 LVPKR 403
>Hs6005922_1 [T] KOG4240 Multidomain protein contains SPEC repeats PH SH3 and
separate rac-specific and rho-specific guanine nucleotide
exchange factor domains
Length = 2559
Score = 56.6 bits (135), Expect = 2e-07
Identities = 56/240 (23%), Positives = 108/240 (44%), Gaps = 30/240 (12%)
Query: 505 LKRNISMAIDDDDEEKSSWTSSVPEELWSSLTK--------REIKRQEA------IYEVY 550
L++ + ++ D + KS +P + S K E KR+ A + E+
Sbjct: 1183 LEKALGISSDSNKSSKSLQLDIIPASIPGSEVKLRDAAHELNEEKRKSARRKEFIMAELI 1242
Query: 551 STEKKFVKSLEILRDTFMKKLAE--TNIIPADIRKNFIKHVFAHVNDIYSVNRRLLDALS 608
TEK +V+ L DT++ ++ I P + K I +F ++ +IY + + L
Sbjct: 1243 QTEKAYVRDLRECMDTYLWEMTSGVEEIPPGIVNKELI--IFGNMQEIYEFHNNIF--LK 1298
Query: 609 ERQKASPIVDGIGDILLRFVPFFEPFVMYVASRPYAKYLIETQRSVNPYFARFDDDLMNS 668
E +K + + +G + + F+ +V Y ++P + LI + FD+
Sbjct: 1299 ELEKYEQLPEDVGHCFVTWADKFQMYVTYCKNKPDSTQLILEHAG-----SYFDEIQQRH 1353
Query: 669 KLRHGIDSFLSQGVSRPGRYVLLVREIMKSTDPETEKRDLENLTRALEALRAFMKRIDKA 728
L + I S+L + V R +Y LL++E++ T E K ++++ LE + + KR + A
Sbjct: 1354 GLANSISSYLIKPVQRITKYQLLLKELL--TCCEEGKGEIKD---GLEVMLSVPKRANDA 1408
>Hs7657365 [T] KOG3523 Putative guanine nucleotide exchange factor TIM
Length = 421
Score = 55.8 bits (133), Expect = 4e-07
Identities = 42/187 (22%), Positives = 92/187 (48%), Gaps = 9/187 (4%)
Query: 546 IYEVYSTEKKFVKSLEILRDTFMKKLAETNIIPADIRKNFIKHVFAHVNDIYSVNRRLLD 605
++E+ ++E + SL IL + F+ ++ + A + + H+F+++ D+ ++R +
Sbjct: 1 MFEILTSEFSYQHSLSILVEEFL----QSKELRATVTQMEHHHLFSNILDVLGASQRFFE 56
Query: 606 ALSERQKASPIVDGIGDILLRFV-PFFEPFVMYVASRPYAKYLIETQRSVNPYFARFDDD 664
L +R KA +V+ I DIL +F P++ Y ++ Y + ++ S N F +
Sbjct: 57 DLEQRHKAQVLVEDISDILEEHAEKYFHPYIAYCSNEVYQQRTLQKLISSNAAFREALRE 116
Query: 665 LMNSKLRHGID--SFLSQGVSRPGRYVLLVREIMKSTDPETEKRDLENLTRALEALRAFM 722
+ G+ SFL + R R LL+ + T +E+ + +RAL+A+ +
Sbjct: 117 IERRPACGGLPMLSFLILPMQRVTRLPLLMDTLCLKTQGHSER--YKAASRALKAISKLV 174
Query: 723 KRIDKAS 729
++ ++ +
Sbjct: 175 RQCNEGA 181
>Hs22047180 [T] KOG4424 Predicted Rho/Rac guanine nucleotide exchange
factor/faciogenital dysplasia protein 3
Length = 725
Score = 55.8 bits (133), Expect = 4e-07
Identities = 61/267 (22%), Positives = 117/267 (42%), Gaps = 39/267 (14%)
Query: 548 EVYSTEKKFVKSLEILRDTFMKKLAETNIIPADIRKNFIKHVFAHVNDIYSVNRRLL--- 604
E+ TE+ +VK L +L F +L + I P I +F++++ I+ + + L
Sbjct: 164 ELLHTEETYVKRLHLLDQVFCTRLTDAGIPP-----EVIMGIFSNISSIHRFHGQFLLPE 218
Query: 605 --DALSERQKASPIVDGIGDILLRFVPFFEPFVMYVASRPYAKYLIETQRSVNPYFARFD 662
++E +P +GDIL + PF + + YV + A L+ T +P F
Sbjct: 219 LKTRITEEWDTNP---RLGDILQKLAPFLKMYGEYVKNFDRAVGLVSTWTQRSPLFKDVV 275
Query: 663 DDLMNSKL--RHGIDSFLSQGVSRPGRYVLLVREIMK-----STDPETEKRDLENLTRAL 715
+ ++ + + + V R RY LL+++ +K + D + +R LE ++ A
Sbjct: 276 HSIQKQEVCGNLTLQHHMLEPVQRVPRYELLLKDYLKRLPQDAPDRKDAERSLELISTAA 335
Query: 716 EALRAFMKRIDKASGAAQDRHDVKLLKQKILFKNEYVNMGLNDDKRKIKHEGLLSRKEIT 775
A +++++K KLL+ Y +G +D +E L+ +I
Sbjct: 336 NHSNAAIRKVEKMH---------KLLE-------VYEQLGGEEDIVNPANE-LIKEGQIQ 378
Query: 776 K--NENGVTGDLQFYLLDNMLLFLKSK 800
K +NG D +L ++M+L+ K
Sbjct: 379 KLSAKNGTPQDRHLFLFNSMILYCVPK 405
>Hs21245128 [T] KOG4424 Predicted Rho/Rac guanine nucleotide exchange
factor/faciogenital dysplasia protein 3
Length = 766
Score = 55.5 bits (132), Expect = 5e-07
Identities = 58/270 (21%), Positives = 117/270 (42%), Gaps = 24/270 (8%)
Query: 539 EIKRQEAIYEVYSTEKKFVKSLEILRDTFMKKLAET---NIIPADIRKNFIKHVFAHVND 595
E K + E+ TE+ +V L++L F KL E PA++ + +F++++
Sbjct: 204 EQKLHKIANELLLTERAYVNRLDLLDQVFYCKLLEEANRGSFPAEM----VNKIFSNISS 259
Query: 596 IYSVNRR-LLDALSERQKASPIVDGIGDILLRFVPFFEPFVMYVASRPYAKYLIETQRSV 654
I + + + LL L +R + IGDIL + PF + + YV A L++
Sbjct: 260 INAFHSKFLLPELEKRMQEWETTPRIGDILQKLAPFLKMYGEYVKGFDNAMELVKNMTER 319
Query: 655 NPYFARFDDDLMNSKLRHG--IDSFLSQGVSRPGRYVLLVREIMKSTDPETEKRDLENLT 712
P F +++ K+ + + + V R RY +L+++ ++ P++ D +
Sbjct: 320 IPQFKSVVEEIQKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDS--LDWNDAK 377
Query: 713 RALEALRAFMKRIDKASGAAQDRHDVKLLKQKILFKNEYVNMGLNDDKRKIKHEGLLSRK 772
++LE + ++ A+ ++ ++ Y +G +D +E L+
Sbjct: 378 KSLEII---------STAASHSNSAIRKMENLKKLLEIYEMLGEEEDIVNPSNE-LIKEG 427
Query: 773 EITK--NENGVTGDLQFYLLDNMLLFLKSK 800
+I K N + +L +NMLL+ K
Sbjct: 428 QILKLAARNTSAQERYLFLFNNMLLYCVPK 457
>Hs4885633 [T] KOG3523 Putative guanine nucleotide exchange factor TIM
Length = 519
Score = 54.3 bits (129), Expect = 1e-06
Identities = 50/218 (22%), Positives = 98/218 (44%), Gaps = 9/218 (4%)
Query: 534 SLTKREIKRQEAIYEVYSTEKKFVKSLEILRDTFMKKLAETNIIPADIRKNFIKHVFAHV 593
S+T + K QE +E+ +E +++SL I D F + + A + + +F+ +
Sbjct: 89 SMTHEDQKLQEVKFELIVSEASYLRSLNIAVDHFQLSTS----LRATLSNQEHQWLFSRL 144
Query: 594 NDIYSVNRRLLDALSERQKASPIVDGIGDILLRFVPFFEP-FVMYVASRPYAKYLIETQR 652
D+ V+ L L E + + + D++L P F ++ YV ++ Y + ++
Sbjct: 145 QDVRDVSATFLSDLEENFENNIFSFQVCDVVLNHAPDFRRVYLPYVTNQTYQERTFQSLM 204
Query: 653 SVNPYFARFDDDLMNSKL--RHGIDSFLSQGVSRPGRYVLLVREIMKSTDPETEKRDLEN 710
+ N F + L + + R + SFL R R LL++ I+K T P + +
Sbjct: 205 NSNSNFREVLEKLESDPVCQRLSLKSFLILPFQRITRLKLLLQNILKRTQPGSSEE--AE 262
Query: 711 LTRALEALRAFMKRIDKASGAAQDRHDVKLLKQKILFK 748
T+A AL ++ + + + ++ L QKI F+
Sbjct: 263 ATKAHHALEQLIRDCNNNVQSMRRTEELIYLSQKIEFE 300
>7292538 [T] KOG4305 RhoGEF GTPase
Length = 1234
Score = 54.3 bits (129), Expect = 1e-06
Identities = 49/202 (24%), Positives = 91/202 (44%), Gaps = 18/202 (8%)
Query: 537 KREIKRQEAIYEVYSTEKKFVKSLEILRDTFMKKLAETNIIPADIRKNFIKHVFAHVNDI 596
K+ ++R+E I E+ TE+K+ + L+I+ + F + ++ + + + +F + D+
Sbjct: 929 KKRVERKEIITEIVETEEKYGRDLQIILEEFCHPM----LVAGLLTQEQLSAIFLNTEDL 984
Query: 597 YSVNRRL-------LDALSERQKASPIVDGIGDILLRFVPFFEPFVMYVASRPYAKYL-- 647
N+ L LD E+ + IG I L F F Y + A L
Sbjct: 985 LENNQTLAERMRDALDMSLEQGDDDLLTVNIGRIFLDFTQMLHAFESYCVRQAGASLLLA 1044
Query: 648 -IETQRSVNPYFARFDDDLMNSKLRH-GIDSFLSQGVSRPGRYVLLVREIMKSTDPETEK 705
+E ++ + F + + N+ LR ++SFL V R +Y LL+ + K T E
Sbjct: 1045 NLEKEKELLRIFLKV-SQMENAVLRRMNLNSFLMVPVQRVTKYPLLLARLYKVTPSHLEG 1103
Query: 706 RDLENLTRALEALRAFMKRIDK 727
R+L L +A E + + I++
Sbjct: 1104 REL--LKQAQEKIELHLNHINQ 1123
>Hs20533821 [T] KOG3521 Predicted guanine nucleotide exchange factor
Length = 930
Score = 53.9 bits (128), Expect = 2e-06
Identities = 67/344 (19%), Positives = 147/344 (42%), Gaps = 59/344 (17%)
Query: 514 DDDDEEKS------SWTSSVPEELWSSLTKREIKRQEAIYEVYSTEKKFVKSLEILRDTF 567
+D+DE+ + SW + LT+R+ +QEA++E+ TE +++ L ++ + F
Sbjct: 305 EDEDEDNACLRLEDSWRELIDGH--EKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLF 362
Query: 568 ---MKKLAETNIIPADIRKNFIKHVFAHVNDIYSVNRRL----LDALSERQKASPIVDGI 620
+ L E+ ++ ++ + +F+++ +I ++RRL + + E+ + + +
Sbjct: 363 LCCLLNLQESGLL-CEVE---AERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALLQP 418
Query: 621 GDILLRFVPF---FEPFVMYVASR----PYAKYLIETQRSVNPYFARFDDDLMNSKLRHG 673
GD L F F F+P++ Y Y + L+ Y + +L+
Sbjct: 419 GDFLKGFKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLK-- 476
Query: 674 IDSFLSQGVSRPGRYVLLVREIMKSTDPETEKRDLENLTRALEALRAFMKRIDKASGAAQ 733
+ L++ R +Y LL++ +++ T+ E R E + + ++ F+ ++ Q
Sbjct: 477 LSDMLAKPHQRLTKYPLLLKSVLRKTE---EPRAKEAVVAMIGSVERFIHHVNACMRQRQ 533
Query: 734 DRHDVKLLKQKI--------------LFKNEYVNMGLN--------DDKRKIKHEGLLSR 771
+R + + +I E++++ L ++ R++ EG L
Sbjct: 534 ERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRM 593
Query: 772 KEITKNENGVTGDLQFYLLDNMLLFLKSKAVNKWNQHKVFQRPI 815
KE G + Y L L +KAV K + +V + P+
Sbjct: 594 KE------GKDSKMDVYCFLFTDLLLVTKAVKKAERTRVIRPPL 631
>CE24103 [T] KOG3520 Predicted guanine nucleotide exchange factor
Length = 1235
Score = 52.4 bits (124), Expect = 4e-06
Identities = 49/222 (22%), Positives = 96/222 (43%), Gaps = 20/222 (9%)
Query: 517 DEEKSSWTSSVPEELWSSLTKREIKRQEAIYEVYSTEKKFVKSLEILRDTFMKKLAETNI 576
++E SW ++L+ +++K+Q+AI+E+Y EK+ ++ L + +++ + NI
Sbjct: 340 NDEYQSWHEKYRH---NTLSTKQVKKQDAIFELYLMEKRHCANIAFLLHGYRRRMLDENI 396
Query: 577 IPADIRKNFIKHVFAHVNDIYSVNRRLLDALSERQKASPIVDGIGDILLRFVPFFEPFVM 636
I I V + + + +L+ ++ R K + V I DI+ +
Sbjct: 397 ITKQDMDVLIPDV---LEPLLIFHLNVLERITARMKENYEVGTISDIISEELAIDGGQHT 453
Query: 637 YVASRPYAKYLIETQRS---------VNPYFARFDDDLMNSKL---RHGIDSFLSQGVSR 684
+ Y + + +RS N FA F + + + +++ + R
Sbjct: 454 KLCCDAYTDFGVAKERSDVLYHHLMNKNAKFAEFFKKTYSEETFYKHYDFRPLITKIIGR 513
Query: 685 PGRYVLLVREIMKSTDPETEKRDLENLTRALEALRAFMKRID 726
+Y LL+ I+K+ P +E DL ALE R F +ID
Sbjct: 514 ATKYSLLLETILKNEQPFSEYHDLTK--TALETARKFAHKID 553
>Hs22054476 [T] KOG3524 Predicted guanine nucleotide exchange factor (PEBBLE)
Length = 762
Score = 52.0 bits (123), Expect = 6e-06
Identities = 48/192 (25%), Positives = 87/192 (45%), Gaps = 9/192 (4%)
Query: 541 KRQEAIYEVYSTEKKFVKSLEILRDTFMKKL-AETNIIPADIRKNFIKHVFAHVNDIYSV 599
KR + E+ +E+K+V+ LEI+RD ++ L A + A + I+ +F + I S+
Sbjct: 446 KRARVVRELLQSERKYVQILEIVRDVYVAPLKAALSSNRAILSAANIQIIFCDILQILSL 505
Query: 600 NRRLLDALSERQKASPIVDGIGDILLRFVPFFEPFVMYVASRPYAKYLIETQRSVNPYFA 659
NR+ LD L +R + +G+I+ +F + + + P IE R + P F
Sbjct: 506 NRQFLDNLRDRLQEWGPAHCVGEIVTKFGSQLNTYTNFFNNYPVILKTIEKCREMIPAFR 565
Query: 660 RF----DDDLMNSKLRHGIDSFLSQGVSRPGRYVLLVREIMKSTDPETEKRDLENLTRAL 715
F D ++ L + L R Y+ L+ + T E D +LT A+
Sbjct: 566 TFLKRHDKTIVTKML--SLPELLLYPSRRFEEYLNLLYAVRLHT--PAEHVDRGDLTTAI 621
Query: 716 EALRAFMKRIDK 727
+ ++ + ID+
Sbjct: 622 DQIKKYKGYIDQ 633
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.318 0.135 0.389
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 69,608,740
Number of Sequences: 60738
Number of extensions: 2976177
Number of successful extensions: 9308
Number of sequences better than 1.0e-05: 47
Number of HSP's better than 0.0 without gapping: 5
Number of HSP's successfully gapped in prelim test: 42
Number of HSP's that attempted gapping in prelim test: 9221
Number of HSP's gapped (non-prelim): 65
length of query: 1227
length of database: 30,389,216
effective HSP length: 118
effective length of query: 1109
effective length of database: 23,222,132
effective search space: 25753344388
effective search space used: 25753344388
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)