ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactII1942 good R KOG3780 General function prediction only Thioredoxin binding protein TBP-2/VDUP1
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactII1942 693510 695621 704
(704 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YGR068c [R] KOG3780 Thioredoxin binding protein TBP-2/VDUP1 328 1e-89
YFR022w [R] KOG3780 Thioredoxin binding protein TBP-2/VDUP1 162 2e-39
YOR018w [R] KOG3780 Thioredoxin binding protein TBP-2/VDUP1 158 3e-38
SPCC584.15c [R] KOG3780 Thioredoxin binding protein TBP-2/VDUP1 119 1e-26
SPAC31A2.12 [R] KOG3780 Thioredoxin binding protein TBP-2/VDUP1 118 3e-26
SPBC2D10.04 [R] KOG3780 Thioredoxin binding protein TBP-2/VDUP1 80 1e-14
YJL084c [R] KOG3780 Thioredoxin binding protein TBP-2/VDUP1 77 9e-14
SPBC839.02 [R] KOG3780 Thioredoxin binding protein TBP-2/VDUP1 55 3e-07
YKR021w [R] KOG3780 Thioredoxin binding protein TBP-2/VDUP1 51 5e-06
>YGR068c [R] KOG3780 Thioredoxin binding protein TBP-2/VDUP1
Length = 586
Score = 328 bits (842), Expect = 1e-89
Identities = 205/513 (39%), Positives = 286/513 (54%), Gaps = 78/513 (15%)
Query: 30 FDIRIASKYGNVKFMSGSALDAEPTVLRGDTVFSLPEALHVKRITLRLVGKFKLEFLQVG 89
FDIRI S Y ++ + GS L+ L G+ V S+ + VK+I+LRLVG+FKLEFLQVG
Sbjct: 25 FDIRINSPYKDIILIQGSPLELSSIPLSGNLVISVKNEIVVKKISLRLVGRFKLEFLQVG 84
Query: 90 QHKNNN--LASIVKEDQTIFEAFWHNLLVDKEGVVLKXXXXXXXXXXXXXXXXXXXXXXX 147
++K N+ LAS+VKE + IFE +W NLLV +G VL
Sbjct: 85 RYKKNSSSLASLVKEKRKIFECYWDNLLVSSKGDVLVGGENAENQHNSSSGRSTSNQDMD 144
Query: 148 XXXXKPILS-RVRSVPIMNNPAKMKLSKTSSPTVLKLPSNGVSGTPYNGT--NAPTGAS- 203
LS R S P+ N + K + +S +L+LP NGV+GTP+ G NA + +S
Sbjct: 145 TSGNAIFLSKRSLSSPVFNKIIRRK-THSSHRKILELPENGVTGTPFEGLRENARSRSSS 203
Query: 204 ----------------------FMLPPGNYELPFQIVFPDDMPETVEGLQSGSVLYTMES 241
F++ GNYELPF + P ++ ET+EGLQSGS+LY+ E+
Sbjct: 204 SNTLNNNSHSYSNRDGSGSSYLFLMKRGNYELPFNTMLPPEVCETIEGLQSGSILYSFEA 263
Query: 242 CIER--------------HG--------------FNKANFTKYEYLRIFRTLKPDNLAIQ 273
I+ HG NK K++YLRI RTL DNLA+Q
Sbjct: 264 IIDGRQLWDTDLSVHTSPHGPIGSTSTSGNGMRTKNKIIIKKFKYLRILRTLSMDNLAMQ 323
Query: 274 EEVTVGKSWPDKLQYEISIPSKAIPIGGATPLTVKLYPFQKGYKLKKIVVSLLQYYAFKD 333
EE++VG +W DKLQYE SIPS+A+PIG TP+ +K++PF+K +L +I ++L+QYYA KD
Sbjct: 324 EEISVGNTWRDKLQYETSIPSRAVPIGSTTPVKIKIFPFEKNIRLDRIEMALIQYYAMKD 383
Query: 334 SAGEVYDDENVIQK-QMLARFDDLPGCDPTQDNLLIDQIKLNSVLQFPDDLKRATQDCDV 392
S+ ++YDDE + K LA F L D++ ++ PD+LK+ TQDC +
Sbjct: 384 SSAQIYDDEIAVMKITHLADFGP-----------LTDKLDVDCPFTIPDNLKQITQDCCL 432
Query: 393 GADLIKVRHKLQVHITLKRNVIHKDKPDDPPYEQSTEIKVNLPIKLYLMEHVPIQGRMVL 452
+LI+V HKLQV I L+R V D Y ++ EIK LP+ L++ H+P++GR+VL
Sbjct: 433 QDNLIRVMHKLQVRILLQRQV-------DGEY-KNLEIKAQLPMLLFISPHLPMKGRLVL 484
Query: 453 LD-HFGKIHFRPGQFCPLFEQSDESNGGTSPAE 484
D H GKIHFRPG+ PLF + + G T E
Sbjct: 485 FDKHDGKIHFRPGELVPLFLTTYPAQGLTPGVE 517
>YFR022w [R] KOG3780 Thioredoxin binding protein TBP-2/VDUP1
Length = 733
Score = 162 bits (409), Expect = 2e-39
Identities = 124/444 (27%), Positives = 204/444 (45%), Gaps = 76/444 (17%)
Query: 23 SKKTPIIFDIRIASKYGNVKFMSGSALDAEPTVLRGDTVFSLPEALHVKRITLRLVGKFK 82
+KK P++FDIR+ + +V + G +A +L G V S+ E + +K I+LRL GK +
Sbjct: 9 TKKKPLLFDIRLKNVDNDVILLKGPPNEAPSVLLSGCIVLSINEPMQIKSISLRLYGKIQ 68
Query: 83 LEF-LQVGQHKNNNLAS-----IVKEDQTIFEAFWHNLLVDKEGVVLKXXXXXXXXXXXX 136
++ L+ Q +++ S I K ++ + W N+ + + L+
Sbjct: 69 IDVPLERPQDASSSSLSSSPPKIRKYNKVFYNYAWDNVNLKEYLSGLRGQSGLAGSSSSS 128
Query: 137 XXXXXXXXXXXXXXXKPILSRVRSVPIMNNPAKMKLSKTSSPTVLKLPSNGVSGTPYNGT 196
+ + TSS LK G+
Sbjct: 129 NILGT---------------------------RQRAQSTSSLKSLK------------GS 149
Query: 197 NAPTGASFMLPPGNYELPFQIVFPDDMPETVEGLQSGSVLYTMESCIERHGFNKANFTKY 256
++P+ + L GNY+ PF + P +PE+VE L + V Y+MES IER N ++
Sbjct: 150 SSPSSCT--LDKGNYDFPFSAILPGSLPESVESLPNCFVTYSMESVIERSK-NYSDLICR 206
Query: 257 EYLRIFRTLKPDNLAIQEEVTVGKSWPDKLQYEISIPSKAIPIGGATPLTVKLYPFQKGY 316
+ +R+ RT+ P + + E V V SWPDK+ Y IS+P+KA+ IG ATP+ + + P KG
Sbjct: 207 KNIRVLRTISPAAVELSETVCVDNSWPDKVDYSISVPNKAVAIGSATPINISIVPLSKGL 266
Query: 317 KLKKIVVSLLQYYAFKDSAGEVYDDENVIQKQML--------------ARFDDLPGCDPT 362
KL I V L + Y + D V + + + L F + P P
Sbjct: 267 KLGSIKVVLFENYQYCDPFPPVISENRQVTELNLEDPLNESSGEFNGNGCFVNNPFFQP- 325
Query: 363 QDNLLIDQIKLNSVLQFPDDLKRATQDCDVGADLIKVRHKLQVHITLKRNVIHKDKPDDP 422
D+ D+ +++++LQ P+ L QDCDV ++ IKVRHKL+ I L HK
Sbjct: 326 -DHSFQDKWEIDTILQIPNSLSNCVQDCDVRSN-IKVRHKLKFFIILINPDGHK------ 377
Query: 423 PYEQSTEIKVNLPIKLYLMEHVPI 446
+E++ +LPI+L++ V +
Sbjct: 378 -----SELRASLPIQLFISPFVAL 396
>YOR018w [R] KOG3780 Thioredoxin binding protein TBP-2/VDUP1
Length = 837
Score = 158 bits (399), Expect = 3e-38
Identities = 123/444 (27%), Positives = 202/444 (44%), Gaps = 77/444 (17%)
Query: 25 KTPIIFDIRIASKYGNVKFMSGSALDAEPTVLRGDTVFSLPEALHVKRITLRLVGKFKLE 84
K P++FDIR+ + +V + G +A +L G V S+ E + +K + LRL G+ +L
Sbjct: 10 KEPLLFDIRLRNLDNDVLLIKGPPDEASSVLLSGTIVLSITEPIQIKSLALRLFGRLRLN 69
Query: 85 FLQVGQHKNNNLASIVKEDQTIFEAFWHNLLVDKEGVVLKXXXXXXXXXXXXXXXXXXXX 144
V Q + K ++ I+ FW +
Sbjct: 70 IPTVLQTVHGPHKRYSKFERNIYSHFWDDF------------------------------ 99
Query: 145 XXXXXXXKPILSRVRSVPIMNNPAKMKLSKTSSPTVLKLPSN--GVSGTPYNGTNAPTGA 202
I S +++ +N K+ +S SS + LP +S +N T A
Sbjct: 100 --------NIKSYFQNLYDNHNNGKITISSKSSTNLAALPKRKRALSTASLISSNGQTSA 151
Query: 203 S---FMLPPGNYELPFQIVFPDDMPETVEGLQSGSVLYTMESCIERHGFNKANFTKYEYL 259
S L GNYE PF + P + E+VEGL + +V Y +E+ IER + + ++L
Sbjct: 152 SKNYHTLVKGNYEFPFSAIIPGSLVESVEGLPNAAVTYALEATIERP--KQPDLICKKHL 209
Query: 260 RIFRTLKPDNLAIQEEVTVGKSWPDKLQYEISIPSKAIPIGGATPLTVKLYPFQKGYKLK 319
R+ RTL D + + E V+V SWP+K+ Y ISIP+KAI IG +T + + + P KG KL
Sbjct: 210 RVIRTLAIDAVELSETVSVDNSWPEKVDYTISIPTKAIAIGSSTMINILIVPILKGLKLG 269
Query: 320 KIVVSLLQYYAFKDSAGEVYDDENVIQKQMLARFDDL-----------------PGCDPT 362
+ +SL++ + S G V + E ++ K L D L G D T
Sbjct: 270 PVRISLVENSQYCGSYGGVINQERMVAKLKLK--DPLKHVAQIKKKRSLNEAADEGVD-T 326
Query: 363 QDNLLIDQIKLNSVLQFPDDLKRATQDCDVGADLIKVRHKLQVHITLKRNVIHKDKPDDP 422
D+ ++ ++L P L + +QDC + ++ IKVRHK++ I+L
Sbjct: 327 DTGEFQDKWEVRALLNIPASLTKCSQDCRILSN-IKVRHKIKFTISLLN----------- 374
Query: 423 PYEQSTEIKVNLPIKLYLMEHVPI 446
P +E++ LP++L++ VP+
Sbjct: 375 PDGHISELRAALPVQLFISPFVPV 398
>SPCC584.15c [R] KOG3780 Thioredoxin binding protein TBP-2/VDUP1
Length = 594
Score = 119 bits (299), Expect = 1e-26
Identities = 75/243 (30%), Positives = 123/243 (49%), Gaps = 19/243 (7%)
Query: 198 APTGASFMLPPGNYELPFQIVFPDDMPETVEGLQSGSVLYTMESCIERHGFNKANFTKYE 257
AP ++ ++ GNYE PF P D+P+++EG+ ++YT+ + +ER N
Sbjct: 99 APNESAKVIDQGNYEYPFYYELPPDIPDSIEGIPGCHIIYTLTASLERATQPPTNLETAL 158
Query: 258 YLRIFRTLKPDNLAIQEEVTVGKSWPDKLQYEISIPSKAIPIGGATPLTVKLYPFQKGYK 317
R+ RT+ P++L + V+V WP K+ YE SIPSK IG P+ + LYP KG
Sbjct: 159 QFRVIRTIPPNSLDLMHSVSVSDIWPLKVNYETSIPSKVYAIGSEIPVNITLYPLLKGLD 218
Query: 318 LKKIVVSLLQYYAFKDSAGEVYDDENVIQKQMLARFDDLPGCDPTQDNLLIDQIKLNSVL 377
+ K+ + L +Y ++ K+ L + +PG P D+ DQI ++
Sbjct: 219 VGKVTLVLKEYCTLFITSKAYSSTCRKEFKRALVK-KTIPGL-PMVDDYWQDQI----MV 272
Query: 378 QFPDDLKRATQDCDVGADLIKVRHKLQVHITLKRNVIHKDKPDDPPYEQSTEIKVNLPIK 437
+ PD L TQDCD+ + I+V HKL++ I+L P +E++ +LP+
Sbjct: 273 KIPDSLGECTQDCDL--NCIRVHHKLRLSISLLN-----------PDGHVSELRNSLPLS 319
Query: 438 LYL 440
L +
Sbjct: 320 LVI 322
>SPAC31A2.12 [R] KOG3780 Thioredoxin binding protein TBP-2/VDUP1
Length = 596
Score = 118 bits (296), Expect = 3e-26
Identities = 73/246 (29%), Positives = 122/246 (48%), Gaps = 30/246 (12%)
Query: 200 TGASFMLPPGNYELPFQIVFPDDMPETVEGLQSGSVLYTMESCIERHGFNKANFTKYEYL 259
TGA+ L GNYE PF ++ P D+ E+VEGLQS V+Y +++ I+R G + K +++
Sbjct: 99 TGANRTLRAGNYEYPFHVMLPGDIAESVEGLQSCYVVYRLKASIDRTGL-ASKMVKKKHI 157
Query: 260 RIFRTLKPDNLAIQEEVTVGKSWPDKLQYEISIPSKAIPIGGATPLTVKLYPFQKGYKLK 319
R+ R L D + + ++V +WP+K++Y IS+P+KA IG P+ L P K +
Sbjct: 158 RLIRALPADAIEYTQTISVDNTWPNKIEYTISVPTKAYAIGSYIPIHFVLVPLLKRLTIG 217
Query: 320 KIVVSLLQYYAFKDSAG-----EVYDDENVIQKQMLARFDDLPGCDPTQDNLLIDQIKLN 374
KI ++L +Y + G D+ ++ ++ D +L
Sbjct: 218 KISITLKEYITLHVAHGYNGLPASKDEVRTVRSLQTEELEEFS-----------DHYELT 266
Query: 375 SVLQFPDDLKRATQDCDVGADLIKVRHKLQVHITLKRNVIHKDKPDDPPYEQSTEIKVNL 434
L+ P L QDCD+ D IK+RHKL+ ++L+ P +E++ L
Sbjct: 267 KNLELPSSLVECLQDCDL--DGIKIRHKLKFSVSLRN-----------PDGHISELRAAL 313
Query: 435 PIKLYL 440
P+ L +
Sbjct: 314 PVVLMI 319
>SPBC2D10.04 [R] KOG3780 Thioredoxin binding protein TBP-2/VDUP1
Length = 658
Score = 79.7 bits (195), Expect = 1e-14
Identities = 60/236 (25%), Positives = 103/236 (43%), Gaps = 11/236 (4%)
Query: 208 PGNYELPFQIVFPDDMPETVEGLQSGSVLYTMESCIERHGFNKANFTKYEYLRIFRTLKP 267
PG Y F + P+ PE+VE + G V Y +E+ +ER G K+N +++ RT P
Sbjct: 272 PGEYTYNFDLAIPNCFPESVEA-KMGWVRYFLEATVERFGTFKSNLNGRTPVQLVRTPSP 330
Query: 268 DNLAIQEEVTVGKSWPDKLQYEISIPSKAIPIGGATPLTVKLYPFQKG--YKLKKIVVSL 325
+L+ E + + + W ++L YE+ + K+ +G P+T + K YKL VV
Sbjct: 331 ASLSSSELINISRDWDERLHYELQVSGKSFRLGEVVPITFRFLLLDKVRLYKLSISVVES 390
Query: 326 LQYYAFKDSAGEVYDDENVIQKQMLARF---DDLPGCDPTQDNLLIDQIKLNSVLQFPDD 382
+Y+ V V+ + A+ D+L D L N L
Sbjct: 391 SEYWCRSRKFHRVDPKRRVLLAERSAKHQNTDNLFETPDEGDGLSSAVFNFNVALPTCLV 450
Query: 383 LKRATQDCDVGADLIKVRHKLQVHITLKRNVIHKDKPDDPPYEQSTEIKVNLPIKL 438
+R D IKVRH+L+ + V+ + ++P + EI + P+++
Sbjct: 451 KERDRLTFDTTYKYIKVRHRLKALL-----VLSIENTENPEKRKYFEINIETPVRI 501
>YJL084c [R] KOG3780 Thioredoxin binding protein TBP-2/VDUP1
Length = 1046
Score = 77.0 bits (188), Expect = 9e-14
Identities = 66/259 (25%), Positives = 118/259 (45%), Gaps = 24/259 (9%)
Query: 185 SNGVSGTPYNGTNAPTGASFMLPPGNYELPFQIVFPDDMPETVEGLQSGSVLYTMESCIE 244
SN ++ T N T+ G F+ PG+Y F+ + P PE+++ G V Y + + IE
Sbjct: 264 SNHLAMTSNNFTSGSGGEFFVFQPGDYIYAFEELIPQAYPESIKA-DFGFVEYFLFASIE 322
Query: 245 RHGFNKANFTKYEYLRIFRTLKPDNLAIQEEVTVGKSWPDKLQYEISIPSKAIPIGGATP 304
R G K+N + + + I RT +++ E + + + W ++L Y+I I SK I + P
Sbjct: 323 RPGAFKSNISARQVVNIVRTQAHNSVEESEPIIISRDWENQLYYDIVIASKDIILDAFLP 382
Query: 305 LTVKLYPFQKG--YKLKKIVVSLLQYYAFKDSAGEVYDDEN-VIQKQMLARFDDLPGCDP 361
+T K P K ++++ V ++YY + + + ++ +Q + +LP
Sbjct: 383 ITFKFAPLDKVTLHRIRIYVTETMEYYCREKKVHRMEPTKKFLLTEQKGPKLPNLP---- 438
Query: 362 TQDNLLIDQIKLNSVLQFPDDLKRATQDCDVGADLIKVRHKLQVHITLKRNVIHKDKPDD 421
D L + ++LQ P + DL+ ++ Q+ I + N H+ D
Sbjct: 439 -NDANLSKAKNMGNLLQDPKN-----------GDLVNKEYEYQIFIPSRFN-NHQQLHPD 485
Query: 422 PPYEQSTEIKVNLPIKLYL 440
YE IK N IK+ L
Sbjct: 486 TSYE---NIKANHWIKICL 501
>SPBC839.02 [R] KOG3780 Thioredoxin binding protein TBP-2/VDUP1
Length = 530
Score = 55.5 bits (132), Expect = 3e-07
Identities = 33/124 (26%), Positives = 58/124 (46%), Gaps = 3/124 (2%)
Query: 208 PGNYELPFQIVFPDDMPETVEGLQSGSVLYTMESCIERHGFNKANFTKYEYLRIFRTLKP 267
PG Y F++ PE+++ G V Y +E+ ++R T + + R+
Sbjct: 190 PGEYVYNFELPISCTYPESIQ-TDMGRVYYFLETLVDRSSTFSGKSTGRIPIELIRSPCS 248
Query: 268 DNLAIQEEVTVGKSWPDKLQYEISIPSKAIPIGGATPLTVK--LYPFQKGYKLKKIVVSL 325
++A E + V KSW D+L YE+ + K + +G P+ K L K +KL+ ++
Sbjct: 249 TSVATSEPILVSKSWEDRLHYEVQVGEKCVVMGQVVPVNFKFTLLGEVKFHKLRLFLMER 308
Query: 326 LQYY 329
YY
Sbjct: 309 RYYY 312
>YKR021w [R] KOG3780 Thioredoxin binding protein TBP-2/VDUP1
Length = 915
Score = 51.2 bits (121), Expect = 5e-06
Identities = 66/285 (23%), Positives = 114/285 (39%), Gaps = 27/285 (9%)
Query: 153 PILSRVRSVPIMNNPAKMKLSKTSSPTVLKLPSN-GVSGTPYNGTNAPTGAS-----FML 206
P SR SVP + + S K SN G + +P N T + F+
Sbjct: 213 PSSSRRGSVPANFHGNSLSPHTFISDLFTKTFSNSGATPSPEQEDNYLTPSKDSKEVFIF 272
Query: 207 PPGNYELPFQIVFPDDMPETVEGLQSGSVLYTMESCIERHGFNKANFTKYEYLRIFRTLK 266
PG+Y F+ PE+++ GSV Y + IER G K+ +++ R
Sbjct: 273 RPGDYIYTFEQPISQSYPESIKA-NFGSVEYKLSIDIERFGAFKSTIHTQLPIKVVRLPS 331
Query: 267 PDNLAIQEEVTVGKSWPDKLQYEISIPSKAIPIGGATPLTVKLYPFQKG--YKLKKIVVS 324
++ E + + K W D L Y++ I SK I + P+ P K ++++ +
Sbjct: 332 DGSVEETEAIAISKDWKDLLHYDVVIFSKEIVLNAFLPIDFHFAPLDKVTLHRIRIYLTE 391
Query: 325 LLQYYAFKDSAGEVYDDENVIQKQMLARFD--DLP----GCDP----TQDNLLIDQIK-- 372
++Y + E +K +LA + LP G +P + N+L+D+
Sbjct: 392 SMEYTCNSNGNHEKARRLEPTKKFLLAEHNGPKLPHIPAGSNPLKAKNRGNILLDEKSGD 451
Query: 373 -LNSVLQF----PDDLKRATQ-DCDVGADLIKVRHKLQVHITLKR 411
+N QF P + + D D IK H +++ + L +
Sbjct: 452 LVNKDFQFEVFVPSKFTNSIRLHPDTNYDKIKAHHWIKICLRLSK 496
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.316 0.136 0.400
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 39,753,609
Number of Sequences: 60738
Number of extensions: 1758283
Number of successful extensions: 4343
Number of sequences better than 1.0e-05: 9
Number of HSP's better than 0.0 without gapping: 6
Number of HSP's successfully gapped in prelim test: 3
Number of HSP's that attempted gapping in prelim test: 4315
Number of HSP's gapped (non-prelim): 14
length of query: 704
length of database: 30,389,216
effective HSP length: 113
effective length of query: 591
effective length of database: 23,525,822
effective search space: 13903760802
effective search space used: 13903760802
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)