ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactII2102 check: MH Q KOG1205 Secondary metabolites biosynthesis, transport and catabolism Predicted dehydrogenase
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactII2102 748323 747520 -268
(268 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YMR226c [Q] KOG1205 Predicted dehydrogenase 375 e-104
SPAC521.03 [Q] KOG1205 Predicted dehydrogenase 229 4e-60
7301818 [Q] KOG1205 Predicted dehydrogenase 112 7e-25
SPAC977.08 [Q] KOG1205 Predicted dehydrogenase 95 9e-20
SPAC1348.09 [Q] KOG1205 Predicted dehydrogenase 95 9e-20
7295621 [Q] KOG1205 Predicted dehydrogenase 94 3e-19
7300831 [Q] KOG1205 Predicted dehydrogenase 92 6e-19
Hs20149619 [Q] KOG1205 Predicted dehydrogenase 92 1e-18
CE21095 [R] KOG0725 Reductases with broad range of substrate spe... 88 1e-17
Hs7706318 [Q] KOG1205 Predicted dehydrogenase 87 2e-17
7297069 [Q] KOG1205 Predicted dehydrogenase 87 2e-17
HsM4506571 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and... 86 7e-17
Hs19743808 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and... 85 1e-16
CE05752 [R] KOG0725 Reductases with broad range of substrate spe... 84 2e-16
Hs13236542 [Q] KOG1205 Predicted dehydrogenase 84 2e-16
CE12990 [R] KOG0725 Reductases with broad range of substrate spe... 84 2e-16
CE03954 [R] KOG0725 Reductases with broad range of substrate spe... 84 2e-16
Hs21361105 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and... 83 5e-16
At1g10310 [R] KOG0725 Reductases with broad range of substrate s... 82 6e-16
7290988 [Q] KOG1205 Predicted dehydrogenase 82 1e-15
At3g03330 [Q] KOG1205 Predicted dehydrogenase 81 2e-15
Hs17455069 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and... 80 2e-15
At5g10050 [Q] KOG1209 1-Acyl dihydroxyacetone phosphate reductas... 79 7e-15
Hs7657478 [Q] KOG1205 Predicted dehydrogenase 78 1e-14
7292613 [Q] KOG1205 Predicted dehydrogenase 77 2e-14
Hs17738292 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and... 77 3e-14
Hs7705905 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 77 3e-14
CE27259 [R] KOG0725 Reductases with broad range of substrate spe... 77 3e-14
CE14538 [R] KOG0725 Reductases with broad range of substrate spe... 76 4e-14
CE28011 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 76 6e-14
CE23899 [R] KOG0725 Reductases with broad range of substrate spe... 76 6e-14
CE12594 [R] KOG0725 Reductases with broad range of substrate spe... 76 6e-14
Hs4504479 [IR] KOG4169 15-hydroxyprostaglandin dehydrogenase and... 75 7e-14
CE21092 [R] KOG0725 Reductases with broad range of substrate spe... 75 7e-14
CE05526 [R] KOG0725 Reductases with broad range of substrate spe... 75 1e-13
CE03951 [R] KOG0725 Reductases with broad range of substrate spe... 75 1e-13
CE21093 [R] KOG0725 Reductases with broad range of substrate spe... 75 1e-13
At5g50700 [Q] KOG1205 Predicted dehydrogenase 75 1e-13
At5g50600 [Q] KOG1205 Predicted dehydrogenase 75 1e-13
7300731 [Q] KOG1205 Predicted dehydrogenase 74 2e-13
Hs20475206 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 74 2e-13
7296705 [R] KOG0725 Reductases with broad range of substrate spe... 74 2e-13
CE27260 [R] KOG0725 Reductases with broad range of substrate spe... 74 3e-13
CE05726 [R] KOG0725 Reductases with broad range of substrate spe... 74 3e-13
CE03132 [R] KOG0725 Reductases with broad range of substrate spe... 74 3e-13
Hs4504501_1 [Q] KOG1205 Predicted dehydrogenase 73 5e-13
CE15574 [R] KOG0725 Reductases with broad range of substrate spe... 72 6e-13
At5g50690 [Q] KOG1205 Predicted dehydrogenase 72 6e-13
At5g50590 [Q] KOG1205 Predicted dehydrogenase 72 6e-13
At3g47360 [Q] KOG1205 Predicted dehydrogenase 72 6e-13
CE20725 [R] KOG0725 Reductases with broad range of substrate spe... 72 8e-13
7296047 [Q] KOG1205 Predicted dehydrogenase 72 8e-13
7294452 [Q] KOG1205 Predicted dehydrogenase 72 1e-12
7292690 [Q] KOG1205 Predicted dehydrogenase 71 1e-12
Hs14735093 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and... 70 2e-12
Hs10047132 [R] KOG0725 Reductases with broad range of substrate ... 70 3e-12
7290108 [R] KOG0725 Reductases with broad range of substrate spe... 70 3e-12
7296706_2 [R] KOG0725 Reductases with broad range of substrate s... 69 5e-12
At3g47350 [Q] KOG1205 Predicted dehydrogenase 69 9e-12
CE26808_2 [R] KOG0725 Reductases with broad range of substrate s... 69 9e-12
At1g07440 [R] KOG0725 Reductases with broad range of substrate s... 68 1e-11
Hs18582884 [Q] KOG1208 Dehydrogenases with different specificiti... 68 2e-11
7293522 [Q] KOG1207 Diacetyl reductase/L-xylulose reductase 67 2e-11
SPCC162.03 [Q] KOG1205 Predicted dehydrogenase 67 3e-11
Hs4506463 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and ... 67 3e-11
CE06649 [R] KOG0725 Reductases with broad range of substrate spe... 67 3e-11
At3g55310 [R] KOG0725 Reductases with broad range of substrate s... 67 3e-11
Hs20070272 [Q] KOG1208 Dehydrogenases with different specificiti... 66 4e-11
7298353 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 ... 66 4e-11
At1g49670_1 [IR] KOG4169 15-hydroxyprostaglandin dehydrogenase a... 66 6e-11
At5g19200 [Q] KOG1210 Predicted 3-ketosphinganine reductase 65 8e-11
At2g29170 [R] KOG0725 Reductases with broad range of substrate s... 65 8e-11
SPAC3G9.02 [R] KOG0725 Reductases with broad range of substrate ... 65 1e-10
CE07544 [Q] KOG1205 Predicted dehydrogenase 65 1e-10
7295487 [R] KOG0725 Reductases with broad range of substrate spe... 65 1e-10
YIL124w [Q] KOG1209 1-Acyl dihydroxyacetone phosphate reductase ... 64 2e-10
Hs19923817 [R] KOG0725 Reductases with broad range of substrate ... 64 2e-10
CE26900 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 64 2e-10
CE09641 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 ... 64 2e-10
At5g50770 [Q] KOG1205 Predicted dehydrogenase 64 2e-10
At2g29150 [R] KOG0725 Reductases with broad range of substrate s... 64 2e-10
7301828 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and re... 64 2e-10
7295622 [Q] KOG1205 Predicted dehydrogenase 64 2e-10
At1g63380 [R] KOG0725 Reductases with broad range of substrate s... 64 3e-10
At1g62610 [R] KOG0725 Reductases with broad range of substrate s... 63 4e-10
7297516 [IR] KOG4169 15-hydroxyprostaglandin dehydrogenase and r... 63 4e-10
Hs7705907 [R] KOG0725 Reductases with broad range of substrate s... 63 5e-10
CE09969 [R] KOG0725 Reductases with broad range of substrate spe... 63 5e-10
CE07539 [Q] KOG1205 Predicted dehydrogenase 63 5e-10
7294126 [IR] KOG4169 15-hydroxyprostaglandin dehydrogenase and r... 63 5e-10
CE26060 [Q] KOG1210 Predicted 3-ketosphinganine reductase 62 6e-10
At5g06060 [R] KOG0725 Reductases with broad range of substrate s... 62 6e-10
At3g06060 [Q] KOG1210 Predicted 3-ketosphinganine reductase 62 6e-10
At3g46170 [R] KOG0725 Reductases with broad range of substrate s... 62 1e-09
Hs14754051 [R] KOG0725 Reductases with broad range of substrate ... 61 1e-09
CE09504 [R] KOG1611 Predicted short chain-type dehydrogenase 61 1e-09
At2g29310 [R] KOG0725 Reductases with broad range of substrate s... 61 1e-09
At5g04900 [R] KOG0725 Reductases with broad range of substrate s... 61 2e-09
7304176 [Q] KOG1208 Dehydrogenases with different specificities ... 61 2e-09
CE19894 [R] KOG0725 Reductases with broad range of substrate spe... 60 3e-09
CE13054 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 60 3e-09
7300947 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 60 3e-09
7293420 [Q] KOG1199 Short-chain alcohol dehydrogenase/3-hydroxya... 60 3e-09
At2g30670 [R] KOG0725 Reductases with broad range of substrate s... 60 4e-09
7298742 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 60 4e-09
Hs4504503 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and ... 59 5e-09
Hs14249446 [I] KOG1200 Mitochondrial/plastidial beta-ketoacyl-AC... 59 5e-09
CE02786 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and re... 59 5e-09
7304181 [Q] KOG1208 Dehydrogenases with different specificities ... 59 5e-09
Hs10337605 [R] KOG0725 Reductases with broad range of substrate ... 59 7e-09
7298167 [IR] KOG4169 15-hydroxyprostaglandin dehydrogenase and r... 59 7e-09
CE08067 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and re... 59 9e-09
CE06423 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 59 9e-09
CE01875 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 ... 59 9e-09
At4g03140 [R] KOG0725 Reductases with broad range of substrate s... 59 9e-09
At2g29350 [R] KOG0725 Reductases with broad range of substrate s... 59 9e-09
7300387 [Q] KOG1208 Dehydrogenases with different specificities ... 59 9e-09
Hs20373187 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 58 1e-08
CE13008 [R] KOG0725 Reductases with broad range of substrate spe... 58 1e-08
7304178 [Q] KOG1208 Dehydrogenases with different specificities ... 58 1e-08
YIR036c [Q] KOG1204 Predicted dehydrogenase 58 2e-08
At2g29370 [R] KOG0725 Reductases with broad range of substrate s... 58 2e-08
At2g29320 [R] KOG0725 Reductases with broad range of substrate s... 58 2e-08
At1g54870 [R] KOG0725 Reductases with broad range of substrate s... 58 2e-08
7304177 [Q] KOG1208 Dehydrogenases with different specificities ... 58 2e-08
At2g29290 [R] KOG0725 Reductases with broad range of substrate s... 57 2e-08
7301303 [Q] KOG1210 Predicted 3-ketosphinganine reductase 57 2e-08
7294121 [IR] KOG4169 15-hydroxyprostaglandin dehydrogenase and r... 57 2e-08
7298168 [IR] KOG4169 15-hydroxyprostaglandin dehydrogenase and r... 57 3e-08
SPAC4H3.08 [R] KOG0725 Reductases with broad range of substrate ... 57 4e-08
SPAC23D3.11 [Q] KOG1209 1-Acyl dihydroxyacetone phosphate reduct... 57 4e-08
Hs5031765 [Q] KOG1205 Predicted dehydrogenase 57 4e-08
At2g29360 [R] KOG0725 Reductases with broad range of substrate s... 57 4e-08
At1g52340 [R] KOG0725 Reductases with broad range of substrate s... 57 4e-08
CE09505 [R] KOG1611 Predicted short chain-type dehydrogenase 56 5e-08
7295674 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 56 5e-08
YLR426w [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 56 6e-08
YDL114w [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 56 6e-08
Hs7705855 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type ... 56 6e-08
At3g51680 [R] KOG0725 Reductases with broad range of substrate s... 56 6e-08
At2g29340 [R] KOG0725 Reductases with broad range of substrate s... 56 6e-08
7304180 [Q] KOG1208 Dehydrogenases with different specificities ... 56 6e-08
Hs4504499 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and ... 55 1e-07
7296704 [R] KOG0725 Reductases with broad range of substrate spe... 55 1e-07
YKR009c [I] KOG1206 Peroxisomal multifunctional beta-oxidation p... 55 1e-07
Hs4758504 [Q] KOG1199 Short-chain alcohol dehydrogenase/3-hydrox... 55 1e-07
CE03127 [Q] KOG1199 Short-chain alcohol dehydrogenase/3-hydroxya... 54 2e-07
Hs4759084 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 54 2e-07
CE07962 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 ... 54 2e-07
At4g13250 [R] KOG0725 Reductases with broad range of substrate s... 54 2e-07
7298352 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 ... 54 2e-07
At2g29330 [R] KOG0725 Reductases with broad range of substrate s... 54 3e-07
At2g29300 [R] KOG0725 Reductases with broad range of substrate s... 54 3e-07
SPCC1739.08c [R] KOG0725 Reductases with broad range of substrat... 53 4e-07
Hs5032035 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and ... 53 4e-07
At5g61830 [Q] KOG1208 Dehydrogenases with different specificitie... 53 4e-07
At5g18210 [R] KOG0725 Reductases with broad range of substrate s... 53 4e-07
At3g26760 [R] KOG0725 Reductases with broad range of substrate s... 53 4e-07
YNL202w [R] KOG0725 Reductases with broad range of substrate spe... 53 5e-07
SPAC922.06 [R] KOG0725 Reductases with broad range of substrate ... 53 5e-07
At3g42960 [R] KOG0725 Reductases with broad range of substrate s... 53 5e-07
At3g03980 [R] KOG0725 Reductases with broad range of substrate s... 53 5e-07
At2g29260 [R] KOG0725 Reductases with broad range of substrate s... 53 5e-07
7290874 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 52 7e-07
7300944 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 52 9e-07
Hs4557649 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type ... 52 1e-06
Hs19923931 [Q] KOG1208 Dehydrogenases with different specificiti... 52 1e-06
CE06316 [Q] KOG1207 Diacetyl reductase/L-xylulose reductase 52 1e-06
CE15790 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 ... 51 1e-06
At1g07450 [R] KOG0725 Reductases with broad range of substrate s... 51 1e-06
7290912 [R] KOG1611 Predicted short chain-type dehydrogenase 51 1e-06
SPCC663.09c [R] KOG1611 Predicted short chain-type dehydrogenase 51 2e-06
At3g29260 [R] KOG0725 Reductases with broad range of substrate s... 50 3e-06
SPCC663.08c [R] KOG1611 Predicted short chain-type dehydrogenase 50 3e-06
Hs22050208 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 50 3e-06
CE07961 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 ... 50 3e-06
7290849 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 ... 50 3e-06
CE19130 [I] KOG1200 Mitochondrial/plastidial beta-ketoacyl-ACP r... 50 4e-06
CE10908 [R] KOG0725 Reductases with broad range of substrate spe... 50 4e-06
CE09002 [R] KOG1611 Predicted short chain-type dehydrogenase 50 4e-06
Hs4502601 [Q] KOG1208 Dehydrogenases with different specificitie... 49 6e-06
CE09001 [R] KOG1611 Predicted short chain-type dehydrogenase 49 6e-06
YIR035c [Q] KOG1204 Predicted dehydrogenase 49 7e-06
At1g24360 [I] KOG1200 Mitochondrial/plastidial beta-ketoacyl-ACP... 49 7e-06
>YMR226c [Q] KOG1205 Predicted dehydrogenase
Length = 267
Score = 375 bits (964), Expect = e-104
Identities = 190/267 (71%), Positives = 221/267 (82%)
Query: 1 MSQGRKAAERLQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXX 60
MSQGRKAAERL KT+ ITGASAGIG+ATALEYL+A+NG++
Sbjct: 1 MSQGRKAAERLAKKTVLITGASAGIGKATALEYLEASNGDMKLILAARRLEKLEELKKTI 60
Query: 61 XXXYPQAKVYIGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDI 120
+P AKV++ QLD+T+ EKI+PFI+NLP+EFKDIDIL+NNAGKALGSD VG I++EDI
Sbjct: 61 DQEFPNAKVHVAQLDITQAEKIKPFIENLPQEFKDIDILVNNAGKALGSDRVGQIATEDI 120
Query: 121 KGMIDTNVVALINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQ 180
+ + DTNV ALIN+TQAVLPIF+AKNSGDIVNLGS+AGRDAYPTGSIYCASK AV AFT
Sbjct: 121 QDVFDTNVTALINITQAVLPIFQAKNSGDIVNLGSIAGRDAYPTGSIYCASKFAVGAFTD 180
Query: 181 SLRKELINTGIRVIEIAPGNVETEFSLVRYKGDADRAKQVYKGTTPLYADDIADLIVYAT 240
SLRKELINT IRVI IAPG VETEFSLVRY+G+ ++AK VYK TTPL ADD+ADLIVYAT
Sbjct: 181 SLRKELINTKIRVILIAPGLVETEFSLVRYRGNEEQAKNVYKDTTPLMADDVADLIVYAT 240
Query: 241 SRKPNTVIADVLVFASNQASPYHIYRG 267
SRK NTVIAD L+F +NQASP+HI+RG
Sbjct: 241 SRKQNTVIADTLIFPTNQASPHHIFRG 267
>SPAC521.03 [Q] KOG1205 Predicted dehydrogenase
Length = 259
Score = 229 bits (583), Expect = 4e-60
Identities = 122/257 (47%), Positives = 171/257 (66%), Gaps = 3/257 (1%)
Query: 10 RLQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKV 69
RL KTI ITGAS+GIG++TA E A V Y + V
Sbjct: 3 RLDGKTILITGASSGIGKSTAFEIAKVAK--VKLILAARRFSTVEEIAKELESKY-EVSV 59
Query: 70 YIGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNVV 129
+LDV++ + I I++LP+EF DID+LINNAG ALG+D V ++ +D MI TNV+
Sbjct: 60 LPLKLDVSDLKSIPGVIESLPKEFADIDVLINNAGLALGTDKVIDLNIDDAVTMITTNVL 119
Query: 130 ALINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKELINT 189
++ +T+AVLPIF +KN GDI+N+GS+AGR++Y GS+YC++K A+ FT +LRKE I+T
Sbjct: 120 GMMAMTRAVLPIFYSKNKGDILNVGSIAGRESYVGGSVYCSTKSALAQFTSALRKETIDT 179
Query: 190 GIRVIEIAPGNVETEFSLVRYKGDADRAKQVYKGTTPLYADDIADLIVYATSRKPNTVIA 249
IR++E+ PG VETEFS+VR+ GD +A VYK + PL +DIA++I++A +R+ N VIA
Sbjct: 180 RIRIMEVDPGLVETEFSVVRFHGDKQKADNVYKNSEPLTPEDIAEVILFALTRRENVVIA 239
Query: 250 DVLVFASNQASPYHIYR 266
D LVF S+Q H+YR
Sbjct: 240 DTLVFPSHQGGANHVYR 256
>7301818 [Q] KOG1205 Predicted dehydrogenase
Length = 326
Score = 112 bits (279), Expect = 7e-25
Identities = 77/251 (30%), Positives = 121/251 (47%), Gaps = 4/251 (1%)
Query: 3 QGRKAAERLQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXX 62
Q +K +L K + ITGAS+G+G++ A + A V
Sbjct: 43 QAQKFRNQLPGKVVLITGASSGLGESLAHVFY-RAGCRVILAARRTQELERVKKDLLALD 101
Query: 63 XYPQAKVYIGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKG 122
P + LD+ E I F+ + + +DILINN G ++ +DV T D+K
Sbjct: 102 VDPAYPPTVLPLDLAELNSIPEFVTRVLAVYNQVDILINNGGISVRADVASTAVDVDLKV 161
Query: 123 MIDTNVVALINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSL 182
M+ N + +T+A+LP + SG I + SV G+ A P + Y ASKHA++AF SL
Sbjct: 162 MV-VNYFGSVALTKALLPSMVKRGSGHICFISSVQGKFAIPQRAAYSASKHAMQAFADSL 220
Query: 183 RKELINTGIRVIEIAPGNVETEFSLVRYKGDADRAKQVYKGTTP-LYADDIADLIVYATS 241
R E+ N I V ++PG + T+ SL G +V + T + D +A+ I+
Sbjct: 221 RAEVANKNINVSCVSPGYIRTQLSLNALTGSGSSYGKVDETTAKGMSPDKLAERILQCIL 280
Query: 242 RK-PNTVIADV 251
RK P+ +++DV
Sbjct: 281 RKEPDIIVSDV 291
>SPAC977.08 [Q] KOG1205 Predicted dehydrogenase
Length = 236
Score = 95.1 bits (235), Expect = 9e-20
Identities = 58/192 (30%), Positives = 103/192 (53%), Gaps = 7/192 (3%)
Query: 69 VYIGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNV 128
V + QLDV I+ ++ F ID+L+NNAG ++ S + T + E I + +TNV
Sbjct: 16 VLVTQLDVNNFSSIKKSVEKAISHFGRIDVLLNNAGYSVYSPLEST-TEEQIHNIFNTNV 74
Query: 129 VALINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKELIN 188
+ V +A+ PIF+++++G I+N+ S+ G+ +P G +Y +K+A+ +++L E+ +
Sbjct: 75 FGALEVIKAITPIFRSQHNGMIINVSSIGGKMTFPLGCLYYGTKYAIEGISEALTWEMQS 134
Query: 189 TGIRVIEIAPGNVETEFSLVRYKGDADRAKQVYKGTTPLYADDIADLIVYATSRKPNTVI 248
G++V I PG TEF R + A + Y +D+ + AT P I
Sbjct: 135 IGVKVKIIEPGFTATEF---RVEEGAGKHYAEYDNLKQKLYEDLLPKLKTAT---PPQKI 188
Query: 249 ADVLVFASNQAS 260
A+V++ A+ S
Sbjct: 189 AEVILQAATDES 200
>SPAC1348.09 [Q] KOG1205 Predicted dehydrogenase
Length = 236
Score = 95.1 bits (235), Expect = 9e-20
Identities = 58/192 (30%), Positives = 103/192 (53%), Gaps = 7/192 (3%)
Query: 69 VYIGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNV 128
V + QLDV I+ ++ F ID+L+NNAG ++ S + T + E I + +TNV
Sbjct: 16 VLVTQLDVNNFSSIKKSVEKAISHFGRIDVLLNNAGYSVYSPLEST-TEEQIHNIFNTNV 74
Query: 129 VALINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKELIN 188
+ V +A+ PIF+++++G I+N+ S+ G+ +P G +Y +K+A+ +++L E+ +
Sbjct: 75 FGALEVIKAITPIFRSQHNGMIINVSSIGGKMTFPLGCLYYGTKYAIEGISEALTWEMQS 134
Query: 189 TGIRVIEIAPGNVETEFSLVRYKGDADRAKQVYKGTTPLYADDIADLIVYATSRKPNTVI 248
G++V I PG TEF R + A + Y +D+ + AT P I
Sbjct: 135 IGVKVKIIEPGFTATEF---RVEEGAGKHYAEYDNLKQKLYEDLLPKLKTAT---PPQKI 188
Query: 249 ADVLVFASNQAS 260
A+V++ A+ S
Sbjct: 189 AEVILQAATDES 200
>7295621 [Q] KOG1205 Predicted dehydrogenase
Length = 247
Score = 93.6 bits (231), Expect = 3e-19
Identities = 71/255 (27%), Positives = 121/255 (46%), Gaps = 26/255 (10%)
Query: 9 ERLQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAK 68
ER N +TGAS+GIG A + + A V +++
Sbjct: 2 ERWHNCVAVVTGASSGIGAAITRKLISAGVMVVALARRMDRLEQLREELPQDR----RSR 57
Query: 69 VYIGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNV 128
+ I Q DV++ + D + + ++DILINNAGK G ++ T+S + ++ M+ TNV
Sbjct: 58 LRIMQCDVSDVSSVNAVFDAVQGDLGNVDILINNAGKLSGGQLL-TMSVDTVQQMLQTNV 116
Query: 129 VALINVTQAVLPIFKAKNS-GDIVNLGSVAGRDAYP--TGS-----IYCASKHAVRAFTQ 180
+ ++ TQ + + S G +V + S+ G + GS +Y A+KHA+ A T+
Sbjct: 117 MGVVYCTQRAFESMRQRQSKGHVVLINSIVGHYIFNPLPGSQQELNMYPATKHAITALTE 176
Query: 181 SLRKEL--INTGIRVIEIAPGNVETEFSLVRYKGDADRAKQVYKGTTPLYADDIADLIVY 238
R+E+ T ++V I+PG V+TE YKG L A+D+A+ I+Y
Sbjct: 177 LFRQEMRDFKTKVKVTSISPGLVDTEL-----------VPLDYKGLPMLQAEDVANAIMY 225
Query: 239 ATSRKPNTVIADVLV 253
S P+ + ++ +
Sbjct: 226 VLSTPPHVQVHELTI 240
>7300831 [Q] KOG1205 Predicted dehydrogenase
Length = 248
Score = 92.4 bits (228), Expect = 6e-19
Identities = 72/249 (28%), Positives = 121/249 (47%), Gaps = 22/249 (8%)
Query: 12 QNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKVYI 71
+NK +TGAS GIG TA+E +A V K++
Sbjct: 8 RNKVAVVTGASVGIGATTAIELANAGMVVVGLARRVELIEALRDQVTGV------GKIFA 61
Query: 72 GQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNVVAL 131
Q D+ + E++ + + E+F+ I +LI NAG L ++ + ++DIK + DTNVVA
Sbjct: 62 RQCDLNDEEQLASAFNWIREKFQAIHVLICNAG-ILKANFLSESPTKDIKELFDTNVVAT 120
Query: 132 IN-VTQAVLPIFKAKNSGDIVNLGSVAGRD----AYPTGSIYCASKHAVRAFTQSLRKEL 186
+ + +A+ + K G IV + SV G P S+Y A+KHA+ A Q++R+E+
Sbjct: 121 ASCLREALKHMAAVKVRGHIVVMNSVLGHRIPEVPVPLFSVYPATKHAITALCQTVRQEI 180
Query: 187 --INTGIRVIEIAPGNVETEFSLVRYKGDADRAKQVYKGTTPLYADDIADLIVYATSRKP 244
+ I++ I PG V+T+F V + A+ K L A D+A ++YA +
Sbjct: 181 HFLKLNIKLTSICPGMVDTDFLSVYSQAVAELPK--------LQARDVAKAVLYALNTPD 232
Query: 245 NTVIADVLV 253
+ D+++
Sbjct: 233 GVQVEDIIL 241
>Hs20149619 [Q] KOG1205 Predicted dehydrogenase
Length = 325
Score = 91.7 bits (226), Expect = 1e-18
Identities = 68/247 (27%), Positives = 114/247 (45%), Gaps = 8/247 (3%)
Query: 11 LQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQA-KV 69
L+N + ITGA++G+G+ A + A V Q K
Sbjct: 50 LRNAVVVITGATSGLGKECAKVFYAAGAKLVLCGRNGGALEELIRELTASHATKVQTHKP 109
Query: 70 YIGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNVV 129
Y+ D+T++ I + + F +DIL+NNAG + ++ T D K +++TN
Sbjct: 110 YLVTFDLTDSGAIVAAAAEILQCFGYVDILVNNAGISYRGTIMDTTVDVD-KRVMETNYF 168
Query: 130 ALINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKELINT 189
+ +T+A+LP + G IV + S+ G+ + P S Y ASKHA +AF LR E+
Sbjct: 169 GPVALTKALLPSMIKRRQGHIVAISSIQGKMSIPFRSAYAASKHATQAFFDCLRAEMEQY 228
Query: 190 GIRVIEIAPGNVETEFSLVRYKGDADR----AKQVYKGTTPLYADDIADLIVYATSRKPN 245
I V I+PG + T S+ D R +G +P+ + D++ +K +
Sbjct: 229 EIEVTVISPGYIHTNLSVNAITADGSRYGVMDTTTAQGRSPV--EVAQDVLAAVGKKKKD 286
Query: 246 TVIADVL 252
++AD+L
Sbjct: 287 VILADLL 293
>CE21095 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 280
Score = 88.2 bits (217), Expect = 1e-17
Identities = 77/260 (29%), Positives = 123/260 (46%), Gaps = 16/260 (6%)
Query: 10 RLQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKV 69
R NKT+ ITG+S GIG+ TA+ L A G + +V
Sbjct: 3 RFSNKTVIITGSSNGIGRTTAI--LFAQEGANVTITGRSSERLEETRQIILKSGVSEKQV 60
Query: 70 YIGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSED----IKGMID 125
DVT + I++ ++F ID+L+NNAG A+ D GT ++ +
Sbjct: 61 NSVVADVTTEDGQDQIINSTLKQFGKIDVLVNNAGAAI-PDAFGTTGTDQGIDIYHKTLK 119
Query: 126 TNVVALINVTQAVLPIFKAKNSGDIVNLGS-VAGRDAYPTGSIYCASKHAVRAFTQSLRK 184
N+ A+I +T+ V P A + G+IVN+ S VAG A P Y +K A+ +T+S
Sbjct: 120 LNLQAVIEMTKKVKPHLVA-SKGEIVNVSSIVAGPQAQPDFLYYAIAKAALDQYTRSTAI 178
Query: 185 ELINTGIRVIEIAPGNVETEFSLVRYKGDADRAKQVYKGTTPLYADDIADLIVYATSRKP 244
+L GIRV ++PG VET F+ G D+A Q + + + I + KP
Sbjct: 179 DLAKFGIRVNSVSPGMVETGFT--NAMGMPDQASQKFYN----FMASHKECIPIGAAGKP 232
Query: 245 NTVIADVLVFASNQASPYHI 264
IA++++F +++ ++I
Sbjct: 233 EH-IANIILFLADRNLSFYI 251
>Hs7706318 [Q] KOG1205 Predicted dehydrogenase
Length = 339
Score = 87.4 bits (215), Expect = 2e-17
Identities = 61/202 (30%), Positives = 98/202 (48%), Gaps = 3/202 (1%)
Query: 3 QGRKAAERLQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXX 62
QGR+ L + +++TGAS+GIG+ A + L ++
Sbjct: 40 QGRRPEWELTDMVVWVTGASSGIGEELAYQ-LSKLGVSLVLSARRVHELERVKRRCLENG 98
Query: 63 XYPQAKVYIGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKG 122
+ + + LD+T+T + + +EF IDIL+NN G + S + T S + +
Sbjct: 99 NLKEKDILVLPLDLTDTGSHEAATKAVLQEFGRIDILVNNGGMSQRSLCMDT-SLDVYRK 157
Query: 123 MIDTNVVALINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSL 182
+I+ N + +++T+ VLP + G IV + S+ G + P YCASKHA+R F L
Sbjct: 158 LIELNYLGTVSLTKCVLPHMIERKQGKIVTVNSILGIISVPLSIGYCASKHALRGFFNGL 217
Query: 183 RKELIN-TGIRVIEIAPGNVET 203
R EL GI V I PG V++
Sbjct: 218 RTELATYPGIIVSNICPGPVQS 239
>7297069 [Q] KOG1205 Predicted dehydrogenase
Length = 246
Score = 87.4 bits (215), Expect = 2e-17
Identities = 71/254 (27%), Positives = 116/254 (44%), Gaps = 20/254 (7%)
Query: 9 ERLQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAK 68
ER QNK +TGAS GIG A A + A V QA
Sbjct: 2 ERWQNKLAVVTGASGGIGAACARAMIGAGLRVVGLARREAKLKELRESLPREL----QAN 57
Query: 69 VYIGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNV 128
+ DV++ +++Q D + E + D+L+NNAG +++V +++ +K +IDTNV
Sbjct: 58 FIPRRCDVSKEDQVQSSFDWIERELEGADVLLNNAGITRETELVTPSNTQKLKEVIDTNV 117
Query: 129 VALINVTQAVLPIFKAK-NSGDIVNLGSVAGR------DAYPTGSIYCASKHAVRAFTQS 181
+ +I T+ K + G ++ + S+AG D P+ +IY A+K A+ A T++
Sbjct: 118 MGVIWCTREAFNNMKRRGGEGHVLIINSIAGHQVLNFIDVLPSFNIYPATKFAITAITET 177
Query: 182 LRKE--LINTGIRVIEIAPGNVETEFSLVRYKGDADRAKQVYKGTTPLYADDIADLIVYA 239
R+E L + IRV I PG V T + K L +IAD ++YA
Sbjct: 178 YRQEFQLHSNKIRVTGICPGAVNTNIF-------PEEIHFYVKDMARLEPANIADAVMYA 230
Query: 240 TSRKPNTVIADVLV 253
P+ ++ + +
Sbjct: 231 LRTPPHVQVSIITI 244
>HsM4506571 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 317
Score = 85.5 bits (210), Expect = 7e-17
Identities = 63/201 (31%), Positives = 102/201 (50%), Gaps = 12/201 (5%)
Query: 5 RKAAERLQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXY 64
R+ L++K +FITG +G G+ A + LDA V
Sbjct: 21 RQVLSHLRDKYVFITGCDSGFGKLLARQ-LDARGLRVLAACLTEKGAEQLRGQTSD---- 75
Query: 65 PQAKVYIGQLDVTETEKIQPFIDNLPEEFKDIDI--LINNAGKALGSDVVGTISSEDIKG 122
++ LDVT+TE + + E +D + L+NNAG +L + ++ +D
Sbjct: 76 ---RLETVTLDVTKTESVAAAAQWVKECVRDKGLWGLVNNAGISLPTAPNELLTKQDFVT 132
Query: 123 MIDTNVVALINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSL 182
++D N++ +I+VT ++LP+ + K G +VN+ SV GR + G YC SK+ V AF+ SL
Sbjct: 133 ILDVNLLGVIDVTLSLLPLVR-KARGRVVNVSSVMGRVSLFGGG-YCISKYGVEAFSDSL 190
Query: 183 RKELINTGIRVIEIAPGNVET 203
R+EL G++V I PG +T
Sbjct: 191 RRELSYFGVKVAMIEPGYFKT 211
>Hs19743808 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 317
Score = 84.7 bits (208), Expect = 1e-16
Identities = 64/220 (29%), Positives = 103/220 (46%), Gaps = 14/220 (6%)
Query: 5 RKAAERLQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXY 64
R+ LQ+K +FITG +G G A + LDA V
Sbjct: 21 RQVVSHLQDKYVFITGCDSGFGNLLARQ-LDARGLRVLAACLTEKGAEQLRGQTSD---- 75
Query: 65 PQAKVYIGQLDVTETEKIQPFIDNLPEEFKDIDI--LINNAGKALGSDVVGTISSEDIKG 122
++ LDVT+ E I + E D + L+NNAG + +++ED
Sbjct: 76 ---RLETVTLDVTKMESIAAATQWVKEHVGDRGLWGLVNNAGILTPITLCEWLNTEDSMN 132
Query: 123 MIDTNVVALINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSL 182
M+ N++ +I VT ++LP+ + + G IVN+ S+ GR A+ G YC SK+ V AF+ L
Sbjct: 133 MLKVNLIGVIQVTLSMLPLVR-RARGRIVNVSSILGRVAFFVGG-YCVSKYGVEAFSDIL 190
Query: 183 RKELINTGIRVIEIAPGNVETEFSLVRYKGDADRAKQVYK 222
R+E+ + G+++ + PG T + +R KQ +K
Sbjct: 191 RREIQHFGVKISIVEPGYFRT--GMTNMTQSLERMKQSWK 228
>CE05752 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 284
Score = 84.3 bits (207), Expect = 2e-16
Identities = 78/269 (28%), Positives = 116/269 (42%), Gaps = 25/269 (9%)
Query: 10 RLQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKV 69
R +K ITG+S GIGQATA L A+ G P+ V
Sbjct: 3 RFTDKVAIITGSSNGIGQATAR--LLASEGAKVTVTGRNAERLEETKNILLGAGVPEGNV 60
Query: 70 YIGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDT--- 126
+ D+T+ + I + ++F IDIL+NNAG + D G + IDT
Sbjct: 61 LVVVGDITQESVQENLIKSTLDKFGKIDILVNNAGAGI-PDAQG---KSGVNQSIDTYHK 116
Query: 127 ----NVVALINVTQAVLPIFKAKNSGDIVNLGSV-AGRDAYPTGSIYCASKHAVRAFTQS 181
NV ++I +TQ P AK G+IVN+ S+ AG A Y +K A+ +T++
Sbjct: 117 TFELNVQSVIEMTQKARPHL-AKTQGEIVNISSIGAGPAAQVASPYYSIAKAALDQYTRT 175
Query: 182 LRKELINTGIRVIEIAPGNVETEFSLVRYKGDADRAKQVY------KGTTP----LYADD 231
+L+ GIRV ++PG V T FS V +++K Y + P +D
Sbjct: 176 AAIDLVPEGIRVNSVSPGAVSTGFSAVSRGLTEEKSKAFYDYLGAQRECIPRGFCAVPED 235
Query: 232 IADLIVYATSRKPNTVIADVLVFASNQAS 260
IA +I + R + I + A S
Sbjct: 236 IAKVIAFLADRNASNYIIGQTIVADGGTS 264
>Hs13236542 [Q] KOG1205 Predicted dehydrogenase
Length = 181
Score = 84.0 bits (206), Expect = 2e-16
Identities = 57/171 (33%), Positives = 90/171 (52%), Gaps = 7/171 (4%)
Query: 96 IDILINNAGKALGSDVVGTISSEDIKGMIDTNVVALINVTQAVLPIFKAKN--SGDIVNL 153
+DI INNAG A D + + S+ K M + NV+AL T+ K +N G I+N+
Sbjct: 12 VDICINNAGLAR-PDTLLSGSTSGWKDMFNVNVLALSICTREAYQSMKERNVDDGHIINI 70
Query: 154 GSVAGRDAYPTG--SIYCASKHAVRAFTQSLRKEL--INTGIRVIEIAPGNVETEFSLVR 209
S++G P Y A+K+AV A T+ LR+EL T IR I+PG VET+F+
Sbjct: 71 NSMSGHRVLPLSVTHFYSATKYAVTALTEGLRQELREAQTHIRATCISPGVVETQFAFKL 130
Query: 210 YKGDADRAKQVYKGTTPLYADDIADLIVYATSRKPNTVIADVLVFASNQAS 260
+ D ++A Y+ L +D+A+ ++Y S + I D+ + + Q +
Sbjct: 131 HDKDPEKAAATYEQMKCLKPEDVAEAVIYVLSTPAHIQIGDIQMRPTEQVT 181
>CE12990 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 279
Score = 84.0 bits (206), Expect = 2e-16
Identities = 73/267 (27%), Positives = 117/267 (43%), Gaps = 24/267 (8%)
Query: 10 RLQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKV 69
R K++ ITG+S+GIG+ATA+ L A NG V
Sbjct: 3 RFAGKSVIITGSSSGIGRATAV--LFAKNGAQVTITGRNAEKLEATKKKLLKVVKTPDSV 60
Query: 70 YIGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDI-KGMIDTNV 128
+ ++T+ + I + ++F IDILINNAG + V T S D+ N
Sbjct: 61 NVVVANLTDAQGQDQIIQSAVKKFGKIDILINNAGANVVDGTVNTDQSIDLYHKTFQINF 120
Query: 129 VALINVTQAVLPIFKAKNSGDIVNLGSVA-GRDAYPTGSIYCASKHAVRAFTQSLRKELI 187
A++ + + + ++ G+IVN+ S+A G A Y A+K A+ +T+ + +LI
Sbjct: 121 QAVVEMVKKTKK-YLIESKGEIVNVSSIAAGPQAVSMSPYYAAAKAALNQYTRCVALDLI 179
Query: 188 NTGIRVIEIAPGNVETEFSLVRYKGDADRAKQVYKGTTPLYA--------------DDIA 233
G+RV ++PG + T F G +Q K L+A +DIA
Sbjct: 180 KQGVRVNSVSPGIIATNF-----MGAMGVPEQAQKKIVNLFASEKGCIPAGVPGKPEDIA 234
Query: 234 DLIVYATSRKPNTVIADVLVFASNQAS 260
+LIV+ + RK + I + A S
Sbjct: 235 ELIVFLSDRKRSFYIVGQSIVADGGTS 261
>CE03954 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 274
Score = 84.0 bits (206), Expect = 2e-16
Identities = 76/265 (28%), Positives = 115/265 (42%), Gaps = 17/265 (6%)
Query: 10 RLQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKV 69
R +K ITG+S GIG+ATA+ L A +G V
Sbjct: 3 RFTDKVAIITGSSNGIGRATAV--LLATDGAKVTITGRDAARLEETRQAILKAGISATNV 60
Query: 70 YIGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGT---ISSEDIKGMIDT 126
DVT E I + ++F I+ILINNAG + T S E++ M
Sbjct: 61 NSVVADVTTAEGQDLLISSTLDKFGKINILINNAGANIPDSQGQTRTKCSIENLTKMFQL 120
Query: 127 NVVALINVTQAVLPIFKAKNSGDIVNLGSV-AGRDAYPTGSIYCASKHAVRAFTQSLRKE 185
N+ +++ + Q V P AK G+IVN+ S+ AG A P Y ++K A+ +++ +
Sbjct: 121 NLQSVVEMVQKVRPHL-AKTRGEIVNISSIGAGPAAQPASPYYSSAKAALDQYSRCAAID 179
Query: 186 LINTGIRVIEIAPGNVETEFSLVRYKGDADRAKQVY--KGTTPL--------YADDIADL 235
LI+ GIR+ + PG V T FS AD + + Y G+ P D +A +
Sbjct: 180 LISEGIRINVVQPGFVSTGFSTAARGLSADESVKFYDLMGSLPHCIPAGYCGQPDHLASV 239
Query: 236 IVYATSRKPNTVIADVLVFASNQAS 260
I + RK + I + A +S
Sbjct: 240 IAFLVDRKVSEYIVGQTIIADGGSS 264
>Hs21361105 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 317
Score = 82.8 bits (203), Expect = 5e-16
Identities = 62/201 (30%), Positives = 102/201 (49%), Gaps = 12/201 (5%)
Query: 5 RKAAERLQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXY 64
R+ L++K +FITG +G G+ A + LDA V
Sbjct: 21 RQVLSHLRDKYVFITGCDSGFGKLLARQ-LDARGLRVLAACLTEKGAEQLRGQTSD---- 75
Query: 65 PQAKVYIGQLDVTETEKIQPFIDNLPEEFKDIDI--LINNAGKALGSDVVGTISSEDIKG 122
++ LDVT+TE + + E +D + L+NNAG +L + ++ +D+
Sbjct: 76 ---RLETVTLDVTKTESVAAAAQWVKECVRDKGLWGLVNNAGISLPTAPNELLTKQDLLT 132
Query: 123 MIDTNVVALINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSL 182
++D N++ +I+VT +LP+ + + G +VN+ SV GR + G YC SK+ V AF+ SL
Sbjct: 133 ILDVNLLGVIDVTLNLLPLVR-RARGRVVNVFSVMGRVSLFGGG-YCISKYGVEAFSDSL 190
Query: 183 RKELINTGIRVIEIAPGNVET 203
R+EL G++V I PG +T
Sbjct: 191 RRELSYFGVKVAMIEPGYFKT 211
>At1g10310 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 242
Score = 82.4 bits (202), Expect = 6e-16
Identities = 51/191 (26%), Positives = 88/191 (45%), Gaps = 7/191 (3%)
Query: 14 KTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKVYIGQ 73
+T+ ITG S G+G+A ALE + + +
Sbjct: 18 RTVLITGVSKGLGRALALELAKRGHTVIGCARSQEKLTALQSELSSSTNHL------LLT 71
Query: 74 LDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNVVALIN 133
DV ++ + E+ DI++NNAG + + +S+ED ++DTNV + N
Sbjct: 72 ADVKSNSSVEEMAHTIVEKKGVPDIIVNNAGTINKNSKIWEVSAEDFDNVMDTNVKGVAN 131
Query: 134 VTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKELINTGIRV 193
V + +P+ + G IVN+ S GR + YCASK A+ ++++ KE++ G+ V
Sbjct: 132 VLRHFIPLMLPRKQGIIVNMSSGWGRSGAALVAPYCASKWAIEGLSRAVAKEVVE-GMAV 190
Query: 194 IEIAPGNVETE 204
+ + PG + TE
Sbjct: 191 VALNPGVINTE 201
>7290988 [Q] KOG1205 Predicted dehydrogenase
Length = 249
Score = 81.6 bits (200), Expect = 1e-15
Identities = 74/256 (28%), Positives = 120/256 (45%), Gaps = 22/256 (8%)
Query: 9 ERLQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAK 68
+R QN+ I+GAS+GIG A A L AA V + +
Sbjct: 2 DRWQNRVAVISGASSGIGAACA-RLLVAAGLQVVGLARRTDRLEQLRQSLPAEQ---RMR 57
Query: 69 VYIGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNV 128
+ + DV++ ++ + + +E ID+LINNAG LG ++ + ++DI ++ TN+
Sbjct: 58 FHQHKCDVSQELQVDTAFEWIEKELGGIDVLINNAGIVLGGQLI-DMPTKDINNILQTNL 116
Query: 129 VALINVTQ-AVLPIFKAKNSGDIVNLGSVAGRDAYPTG------SIYCASKHAVRAFTQS 181
+ I T+ A + + + +G ++ + S AG Y + Y SK A+ A +
Sbjct: 117 MGSIYCTKLAASSMRRRQVAGHLIFVNSTAGVAGYKPDPADESLNAYTPSKFALTAVQEI 176
Query: 182 LRKELINTG--IRVIEIAPGNVETEFSLVRYKGDADRAKQVYKGTTPLYADDIADLIVYA 239
R+ELIN G I+ I PG V TE D +AK G L ADD+A ++YA
Sbjct: 177 CRQELINQGSKIKTTSINPGWVATEI-----VPDETKAK---LGEVILQADDVAQAVLYA 228
Query: 240 TSRKPNTVIADVLVFA 255
S P+T + + + A
Sbjct: 229 LSTPPHTQVEQITLRA 244
>At3g03330 [Q] KOG1205 Predicted dehydrogenase
Length = 345
Score = 80.9 bits (198), Expect = 2e-15
Identities = 56/198 (28%), Positives = 88/198 (44%), Gaps = 6/198 (3%)
Query: 9 ERLQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAK 68
E +Q K ++ITGAS GIG+ A ++ A+ + +
Sbjct: 39 EAIQGKVVWITGASRGIGEILAKQF---ASLDAKLILSARNKAELDRVKSELKGKFAPED 95
Query: 69 VYIGQLDVTETEK-IQPFIDNLPEEFKD--IDILINNAGKALGSDVVGTISSEDIKGMID 125
V + LD+ E+ ++ ++ F +D L++NA S E +K D
Sbjct: 96 VKVLPLDLASGEESLKHVVEQAVSLFPGAGVDYLVHNAAFERPKSKASDASEETLKTTFD 155
Query: 126 TNVVALINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKE 185
NV I++T+ V P + G V + S AG+ P +IY ASKHA+ + SLR E
Sbjct: 156 VNVFGTISLTKLVAPHMLKQGGGHFVVISSAAGKVPSPGQAIYSASKHALHGYFHSLRSE 215
Query: 186 LINTGIRVIEIAPGNVET 203
GI+V + PG +ET
Sbjct: 216 FCQKGIKVTVVCPGPIET 233
>Hs17455069 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 313
Score = 80.5 bits (197), Expect = 2e-15
Identities = 60/195 (30%), Positives = 92/195 (46%), Gaps = 12/195 (6%)
Query: 11 LQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKVY 70
L K +FITG +G G A + +D + ++
Sbjct: 23 LSEKYVFITGCDSGFGNLLAKQLVDRGMQVLAACFTEEGSQKLQRDTSY--------RLQ 74
Query: 71 IGQLDVTETEKIQPFIDNLPEEFKDIDI--LINNAGKALGSDVVGTISSEDIKGMIDTNV 128
LDVT++E I+ + ++ + + L+NNAG L S ++ +D +I+ N+
Sbjct: 75 TTLLDVTKSESIKAAAQWVRDKVGEQGLWALVNNAGVGLPSGPNEWLTKDDFVKVINVNL 134
Query: 129 VALINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKELIN 188
V LI VT +LP+ K + G +VN+ S GR A G YC SK V AF+ S+R+EL
Sbjct: 135 VGLIEVTLHMLPMVK-RARGRVVNMSSSGGRVAVIGGG-YCVSKFGVEAFSDSIRRELYY 192
Query: 189 TGIRVIEIAPGNVET 203
G++V I PGN T
Sbjct: 193 FGVKVCIIEPGNYRT 207
>At5g10050 [Q] KOG1209 1-Acyl dihydroxyacetone phosphate reductase and related
dehydrogenases
Length = 299
Score = 79.0 bits (193), Expect = 7e-15
Identities = 58/219 (26%), Positives = 93/219 (41%), Gaps = 38/219 (17%)
Query: 12 QNKTIFITGAS-AGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKVY 70
++ + ITG S GIG A A E+ + V ++++
Sbjct: 6 ESPVVLITGCSQGGIGHALAREFTEKGCRVVATSRSRSTMTDLEQ----------DSRLF 55
Query: 71 IGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDT---- 126
+ +LDV + + + + ++F ID+L+NNAG VG ++ I M +T
Sbjct: 56 VKELDVQSDQNVSKVLSEVIDKFGKIDVLVNNAGV----QCVGPLAETPISAMENTFNTN 111
Query: 127 -------------------NVVALINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSI 167
N + +TQAV+P +K G IVN+GS+ P +
Sbjct: 112 VFGNKDLIFSFNYYIYWSFNSSGSMRMTQAVVPHMVSKKKGKIVNVGSITVMAPGPWAGV 171
Query: 168 YCASKHAVRAFTQSLRKELINTGIRVIEIAPGNVETEFS 206
Y A+K A+ A T +LR EL GI VI + PG + T +
Sbjct: 172 YTATKAAIHALTDTLRLELRPFGIDVINVVPGGIRTNIA 210
>Hs7657478 [Q] KOG1205 Predicted dehydrogenase
Length = 311
Score = 77.8 bits (190), Expect = 1e-14
Identities = 54/192 (28%), Positives = 85/192 (44%), Gaps = 5/192 (2%)
Query: 14 KTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKVYIGQ 73
+T+ I+G S+GIG A++ Q + + Q
Sbjct: 6 RTVLISGCSSGIGLELAVQLAHDPKKRYQVVATMRDLGKKETLEAAAGEALGQT-LTVAQ 64
Query: 74 LDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNVVALIN 133
LDV E + + + E +D+L+NNAG L + G +S ++ + DTN +
Sbjct: 65 LDVCSDESVAQCLSCIQGE---VDVLVNNAGMGLVGPLEG-LSLAAMQNVFDTNFFGAVR 120
Query: 134 VTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKELINTGIRV 193
+ +AVLP K + G IV + SV G +Y ASK A+ F +SL +L+ I +
Sbjct: 121 LVKAVLPGMKRRRQGHIVVISSVMGLQGVIFNDVYAASKFALEGFFESLAIQLLQFNIFI 180
Query: 194 IEIAPGNVETEF 205
+ PG V TEF
Sbjct: 181 SLVEPGPVVTEF 192
>7292613 [Q] KOG1205 Predicted dehydrogenase
Length = 250
Score = 77.4 bits (189), Expect = 2e-14
Identities = 64/255 (25%), Positives = 118/255 (46%), Gaps = 23/255 (9%)
Query: 9 ERLQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAK 68
ER QN+ +TGAS+GIG A A + + A V + K
Sbjct: 2 ERWQNRVAVVTGASSGIGSAIAKDLVLAGMTVVGLARRVDRVKELQRELPAE----KRGK 57
Query: 69 VYIGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNV 128
++ DV + D + ++ ID+L+NNAG L + ++ ++ ++ TN+
Sbjct: 58 LFALYCDVGNESSVNEAFDWIIQKLGAIDVLVNNAG-TLQPGYLVDMNPAVMQQVLQTNI 116
Query: 129 VALINVTQ-AVLPIFKAKNSGDIVNLGSVAGRDAY-------PTGSIYCASKHAVRAFTQ 180
+ ++ TQ AV + + K G +V + S+ G P ++Y SKHAV A +
Sbjct: 117 MGIVLCTQRAVRSMRERKFDGHVVLINSILGHKTMTATEGVAPDVNVYPPSKHAVTALAE 176
Query: 181 SLRKEL--INTGIRVIEIAPGNVETEFSLVRYKGDADRAKQVYKGTTPLYADDIADLIVY 238
R+E + T I++ ++PG V+TE D ++ K L+++DIA ++Y
Sbjct: 177 GYRQEFFGLGTRIKITSVSPGVVDTEIV-------PDSIREAIKDRM-LHSEDIAQGVLY 228
Query: 239 ATSRKPNTVIADVLV 253
A + P+ + ++++
Sbjct: 229 AIATPPHVQVHELII 243
>Hs17738292 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 343
Score = 77.0 bits (188), Expect = 3e-14
Identities = 58/207 (28%), Positives = 101/207 (48%), Gaps = 16/207 (7%)
Query: 73 QLDVTETEKIQPFIDNLPEEFKDIDI----LINNAGKALGSDVVGTISSEDIKGMIDTNV 128
QL+V +E+++ ++ + KD + L+NNAG + +V T S E K + + N+
Sbjct: 111 QLNVCSSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGISTFGEVEFT-SLETYKQVAEVNL 169
Query: 129 VALINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKELIN 188
+ +T++ LP+ + + G +VN+ S+ GR A P S YC +K V AF+ LR E+
Sbjct: 170 WGTVRMTKSFLPLIR-RAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYP 228
Query: 189 TGIRVIEIAPGNVETEFSLVRYKGDADRAKQVYKGTTPLYADD---------IADLIVYA 239
G++V + PGN SL + AK++++ + D IA + Y
Sbjct: 229 LGVKVSVVEPGNFIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYC 288
Query: 240 TSRKPNT-VIADVLVFASNQASPYHIY 265
+S +T + D + A +PY Y
Sbjct: 289 SSGSTDTSPVIDAVTHALTATTPYTRY 315
>Hs7705905 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 300
Score = 76.6 bits (187), Expect = 3e-14
Identities = 60/203 (29%), Positives = 86/203 (41%), Gaps = 9/203 (4%)
Query: 6 KAAERLQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYP 65
K + + + + ITGA GIG+ TA E+ + V
Sbjct: 29 KRRKSVTGEIVLITGAGHGIGRLTAYEFAKLKSKLVLWDINKHGLEETAAKCKGLG---- 84
Query: 66 QAKVYIGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMID 125
AKV+ +D + E I + E D+ IL+NNAG SD+ T I+ +
Sbjct: 85 -AKVHTFVVDCSNREDIYSSAKKVKAEIGDVSILVNNAGVVYTSDLFAT-QDPQIEKTFE 142
Query: 126 TNVVALINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKE 185
NV+A T+A LP N G IV + S AG + P YC+SK A F ++L E
Sbjct: 143 VNVLAHFWTTKAFLPAMTKNNHGHIVTVASAAGHVSVPFLLAYCSSKFAAVGFHKTLTDE 202
Query: 186 LIN---TGIRVIEIAPGNVETEF 205
L TG++ + P V T F
Sbjct: 203 LAALQITGVKTTCLCPNFVNTGF 225
>CE27259 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 501
Score = 76.6 bits (187), Expect = 3e-14
Identities = 64/230 (27%), Positives = 99/230 (42%), Gaps = 10/230 (4%)
Query: 18 ITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKVYIGQLDVT 77
+TGAS+GIG+A AL L A N + V + +++
Sbjct: 6 VTGASSGIGRAAAL--LLARNNYKLSLTGRNVAALNELAGQIVSAGSDKNDVLVTAVELA 63
Query: 78 ETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNVVALINVTQA 137
E + +D ++F ID LIN+AG V+ + E +++ NV +LI +T+A
Sbjct: 64 SEEAPKTIVDATVQKFGRIDTLINSAGILRAGPVLDS-GIEVYDELMNVNVRSLIRLTRA 122
Query: 138 VLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKELINTGIRVIEIA 197
LP G +VN+ S+ G +P + YC SK AV FT+ L E+ G+RV +
Sbjct: 123 ALPHI-ITTKGTVVNVSSINGPCPFPNVTYYCMSKSAVDQFTKCLALEMAPNGVRVNAVC 181
Query: 198 PGNVETEF------SLVRYKGDADRAKQVYKGTTPLYADDIADLIVYATS 241
PG T Y +R+K + P Y +I A+S
Sbjct: 182 PGVTVTNLHRTSGQDETTYSAFLERSKTTHALGRPEYPKMPVAIITGASS 231
Score = 53.1 bits (126), Expect = 4e-07
Identities = 35/104 (33%), Positives = 54/104 (51%), Gaps = 2/104 (1%)
Query: 100 INNAGKALGSDVVGTISSEDIKGMIDTNVVALINVTQAVLPIFKAKNSGDIVNLGSVAGR 159
IN+AG V+ + E +++ NV +LI +T+A LP G +VN+ S+ G
Sbjct: 381 INSAGILRAGPVLDS-GIEVYDELMNVNVRSLIRLTRAALPHI-ITTKGTVVNVSSINGP 438
Query: 160 DAYPTGSIYCASKHAVRAFTQSLRKELINTGIRVIEIAPGNVET 203
+ + YC SK AV FT+ L E+ G+RV + PG + T
Sbjct: 439 CPFAGVTYYCMSKSAVDQFTKCLALEMAPNGVRVNAVCPGVIVT 482
>CE14538 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 280
Score = 76.3 bits (186), Expect = 4e-14
Identities = 74/263 (28%), Positives = 120/263 (45%), Gaps = 23/263 (8%)
Query: 8 AERLQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQA 67
A+R ++ +TG+S GIG+ATA+ L A+ G P
Sbjct: 2 AQRFTDEVAIVTGSSNGIGRATAI--LLASEGAKVTITGRNAERLEESRQALLKVGVPSG 59
Query: 68 KVYIGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDT- 126
+ DVT ID+ ++F I+ILINNAG + T +S ++ + T
Sbjct: 60 HINSVVADVTTGAGQDVLIDSTLKKFGKINILINNAGALIVDPEGKTNTSTGVETCLKTF 119
Query: 127 --NVVALINVTQAVLPIFKAKNSGDIVNLGSV-AGRDAYPTGSIYCASKHAVRAFTQSLR 183
N +++ +TQ + P A G+IVN+ SV AG A Y A+K A+ ++++
Sbjct: 120 QLNFQSVVEMTQKIRPHL-ANTHGEIVNVSSVGAGPAAENRFPYYSAAKAALDQYSRNTA 178
Query: 184 KELINTGIRVIEIAPGNVETEFSLVRYKGDADRAKQVYKG----TTPLYA------DDIA 233
+LI GIRV + PG V T F+ D + ++Y+G T+ + A + +A
Sbjct: 179 IDLIPDGIRVNIVQPGFVATGFTTAASGMSPDASAKMYEGIGANTSCIPAGYCGRPEHLA 238
Query: 234 DLIVYATSRKPN------TVIAD 250
+I + RK + T+IAD
Sbjct: 239 SVIAFLADRKASEYIVGQTIIAD 261
>CE28011 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 427
Score = 75.9 bits (185), Expect = 6e-14
Identities = 53/185 (28%), Positives = 86/185 (45%), Gaps = 6/185 (3%)
Query: 11 LQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKVY 70
+Q +T+ ITG +G+G+A AL++ A AK +
Sbjct: 39 VQGQTVIITGGGSGLGRAMALDF---AKRKAKVAIIDVNKEGGLETVKTIAAEGNMAKFW 95
Query: 71 IGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNVVA 130
D+++ + ++ + + F D++I+I NA L IS E ++ +D N+
Sbjct: 96 Y--CDISDVDNMKKTAKEIEDTFGDVNIVICNAA-ILSFTSFMEISDELLRKCLDVNIFG 152
Query: 131 LINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKELINTG 190
IN +A LP + KN G IV + S+AG G YC SK AVR +SL+ EL + G
Sbjct: 153 TINTIRAFLPKMETKNDGHIVCVCSIAGWSGETMGLSYCTSKFAVRGAMESLQMELRDRG 212
Query: 191 IRVIE 195
+ I+
Sbjct: 213 LEGIK 217
>CE23899 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 279
Score = 75.9 bits (185), Expect = 6e-14
Identities = 60/201 (29%), Positives = 95/201 (46%), Gaps = 9/201 (4%)
Query: 10 RLQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKV 69
R K +TG+S GIG+ATA+ L A G P+ V
Sbjct: 3 RFSGKVALVTGSSNGIGRATAV--LLAQEGAKVTITGRNADRLEETRQEILKSGVPEDHV 60
Query: 70 YIGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIK---GMIDT 126
D+ + +++ ++F +DIL+NNAG A D +D+ ++
Sbjct: 61 LSIATDLATEKGQDELVNSTIQKFGRLDILVNNAGAAFNDDQGRVGVDQDVSVYDRIMQI 120
Query: 127 NVVALINVTQ-AVLPIFKAKNSGDIVNLGSV-AGRDAYPTGSIYCASKHAVRAFTQSLRK 184
N+ +++ +TQ A + KAK G++VN+ S+ AG A PT Y SK A+ +T+S
Sbjct: 121 NMRSVVTLTQKAKEHLVKAK--GEVVNVSSIGAGPQAQPTFMYYAMSKAALDQYTRSAAI 178
Query: 185 ELINTGIRVIEIAPGNVETEF 205
+LI G+RV ++PG V T F
Sbjct: 179 DLIQYGVRVNSVSPGAVVTGF 199
>CE12594 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 277
Score = 75.9 bits (185), Expect = 6e-14
Identities = 58/198 (29%), Positives = 87/198 (43%), Gaps = 5/198 (2%)
Query: 10 RLQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKV 69
R K+I ITG+S+GIG++ A+ + A G P K+
Sbjct: 3 RFSGKSIIITGSSSGIGRSAAVIF--AKEGAQVTITGRSADRLEETRLQILKAGVPAEKI 60
Query: 70 YIGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDI-KGMIDTNV 128
DV E I +F IDIL+NNAG L T + ++ + N
Sbjct: 61 NAVVADVCEASGQDEVIRTTLAKFGKIDILVNNAGALLTDGTSNTDQAVELYQKTFKLNF 120
Query: 129 VALINVTQAVLPIFKAKNSGDIVNLGS-VAGRDAYPTGSIYCASKHAVRAFTQSLRKELI 187
A++ +TQ + K G+IVN+ S VAG A P Y +K A+ +T+ +LI
Sbjct: 121 QAVVEMTQKTKE-YLIKTKGEIVNVSSIVAGPQAQPASPYYACAKAALDQYTRCTAIDLI 179
Query: 188 NTGIRVIEIAPGNVETEF 205
G+RV ++PG + T F
Sbjct: 180 QHGVRVNSVSPGVIATGF 197
>Hs4504479 [IR] KOG4169 15-hydroxyprostaglandin dehydrogenase and related
dehydrogenases
Length = 266
Score = 75.5 bits (184), Expect = 7e-14
Identities = 66/254 (25%), Positives = 108/254 (41%), Gaps = 24/254 (9%)
Query: 11 LQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKVY 70
+ K +TGA+ GIG+A A L G PQ ++
Sbjct: 3 VNGKVALVTGAAQGIGRAFAEALL--LKGAKVALVDWNLEAGVQCKAALHEQFEPQKTLF 60
Query: 71 IGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNVVA 130
I Q DV + ++++ + + F +DIL+NNAG + ++ + + N+V+
Sbjct: 61 I-QCDVADQQQLRDTFRKVVDHFGRLDILVNNAG---------VNNEKNWEKTLQINLVS 110
Query: 131 LINVTQAVLPIFKAKNSGD---IVNLGSVAGRDAYPTGSIYCASKHAVRAFTQS--LRKE 185
+I+ T L +N G+ I+N+ S+AG +YCASKH + FT+S L
Sbjct: 111 VISGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAAN 170
Query: 186 LINTGIRVIEIAPGNVETEFSLVRYKGDADRAKQVYKGTTPLYADDIADLIVYATSRKPN 245
L+N+G+R+ I PG V T K+ G Y D I D+I Y P
Sbjct: 171 LMNSGVRLNAICPGFVNTAIL-------ESIEKEENMGQYIEYKDHIKDMIKYYGILDPP 223
Query: 246 TVIADVLVFASNQA 259
+ ++ + A
Sbjct: 224 LIANGLITLIEDDA 237
>CE21092 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 278
Score = 75.5 bits (184), Expect = 7e-14
Identities = 75/260 (28%), Positives = 111/260 (41%), Gaps = 15/260 (5%)
Query: 10 RLQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKV 69
R +K ITG+S+GIG++TA+ L A G +
Sbjct: 3 RFSDKVAIITGSSSGIGRSTAV--LLAQEGAKVTVTGRSSEKIQETVNEIHKNGGSSDNI 60
Query: 70 YIGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDT--- 126
I D+ E+E I + F IDILINNAG A +D G I SE G+ D
Sbjct: 61 NIVLGDLNESECQDELIKSTLSRFGKIDILINNAGAAF-ADPSGKIGSEAAIGIFDDMMK 119
Query: 127 -NVVALINVTQAVLPIFKAKNSGDIVNLGSVA-GRDAYPTGSIYCASKHAVRAFTQSLRK 184
N+ +++ + + P A + G+IVN+ S+A G Y + Y K + T+SL
Sbjct: 120 LNLRSVVELVKKCRPHLIA-SKGEIVNVSSIAAGPQPYIYYTYYGICKAGLDQLTRSLAL 178
Query: 185 ELINTGIRVIEIAPGNVETEFSLVRYKGDADRAKQVYKGTTPLYADDIADLIVYATSRKP 244
ELI +RV ++PG + T F G V K T Y+ D I + KP
Sbjct: 179 ELIPFDVRVNSVSPGLISTNF-----LGAVGMGDDVVKKTEEYYSTH-RDCIPAGRTGKP 232
Query: 245 NTVIADVLVFASNQASPYHI 264
+ + + A ++S Y I
Sbjct: 233 EEIASLIAFLADRKSSAYII 252
>CE05526 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 278
Score = 75.1 bits (183), Expect = 1e-13
Identities = 70/253 (27%), Positives = 108/253 (42%), Gaps = 18/253 (7%)
Query: 10 RLQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKV 69
R K ITG+S GIG+ATA+ L A G + V
Sbjct: 3 RFAEKVAIITGSSNGIGRATAV--LFAREGAKVTITGRHAERLEETRQQILAAGVSEQNV 60
Query: 70 YIGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKAL--GSDVVGTISS-EDIKGMIDT 126
DVT + +F +DIL+NNAG A+ GT S E ++
Sbjct: 61 NSVVADVTTDAGQDEILSTTLGKFGKLDILVNNAGAAIPDSQSKTGTAQSIESYDATLNL 120
Query: 127 NVVALINVTQAVLPIFKAKNSGDIVNLGSVA-GRDAYPTGSIYCASKHAVRAFTQSLRKE 185
N+ ++I +T+ +P + G+IVN+ S+A G A P Y +K A+ +T++ +
Sbjct: 121 NLRSVIALTKKAVPHLSS-TKGEIVNISSIASGLHATPDFPYYSIAKAAIDQYTRNTAID 179
Query: 186 LINTGIRVIEIAPGNVETEFSLVRYKGDADRAKQVYKGTTPL----------YADDIADL 235
LI GIRV I+PG V T F + + +K+ Y + DIA++
Sbjct: 180 LIQHGIRVNSISPGLVATGFGSAMGMPE-ETSKKFYSTMATMKECVPAGVMGQPQDIAEV 238
Query: 236 IVYATSRKPNTVI 248
I + RK ++ I
Sbjct: 239 IAFLADRKTSSYI 251
>CE03951 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 277
Score = 75.1 bits (183), Expect = 1e-13
Identities = 62/200 (31%), Positives = 91/200 (45%), Gaps = 7/200 (3%)
Query: 10 RLQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKV 69
R K ITG+S GIG+ATAL L A G +
Sbjct: 4 RFSGKVAIITGSSFGIGRATAL--LFAKEGAKVTVTGRSEERLQGSKQALLDAGISDSNF 61
Query: 70 YIGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDI---KGMIDT 126
I D+T + I E+F I+IL+NNAG ++ + I + ++
Sbjct: 62 LIVPADITTSSGQDALISKTLEKFGQINILVNNAGASIADSQNRAGLDQGIDTYEKVLKL 121
Query: 127 NVVALINVTQAVLPIFKAKNSGDIVNLGSVAG-RDAYPTGSIYCASKHAVRAFTQSLRKE 185
NV ++I +TQ + P AK G+IVN+ SVA + A+ Y +K A+ +T+S +
Sbjct: 122 NVQSVIEMTQKIRPHL-AKTRGEIVNVSSVAALKFAHVRNPYYPLAKAALDQYTRSAAID 180
Query: 186 LINTGIRVIEIAPGNVETEF 205
LI+ GIRV + PG V T F
Sbjct: 181 LISQGIRVNTVNPGVVATGF 200
>CE21093 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 281
Score = 74.7 bits (182), Expect = 1e-13
Identities = 59/201 (29%), Positives = 94/201 (46%), Gaps = 9/201 (4%)
Query: 10 RLQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKV 69
R K +TG+S GIG+A A+ L A +G P++ V
Sbjct: 4 RFSGKVALVTGSSNGIGRAAAV--LFAKDGAKVTVTGRNAERLEETRQEILKSGVPESHV 61
Query: 70 YIGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIK---GMIDT 126
D+ + +++ ++F +DIL+NNAG A D +D+ ++
Sbjct: 62 LSVATDLAAEKGQDELVNSTIQKFGRLDILVNNAGAAFNDDQGRVGVDQDVSVYDKIMQI 121
Query: 127 NVVALINVTQ-AVLPIFKAKNSGDIVNLGSVAGR-DAYPTGSIYCASKHAVRAFTQSLRK 184
N+ +++ +TQ A + KAK G+IVN+ S+AG A P Y SK A+ FT+
Sbjct: 122 NMRSVVTLTQKAKEHLVKAK--GEIVNVSSIAGTAHAQPGVMYYAMSKSALDQFTRCAAI 179
Query: 185 ELINTGIRVIEIAPGNVETEF 205
+LI G+RV ++PG V T F
Sbjct: 180 DLIQYGVRVNSVSPGGVTTGF 200
>At5g50700 [Q] KOG1205 Predicted dehydrogenase
Length = 349
Score = 74.7 bits (182), Expect = 1e-13
Identities = 59/203 (29%), Positives = 89/203 (43%), Gaps = 6/203 (2%)
Query: 8 AERLQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQA 67
+E L K + ITGAS+GIG+ A EY A G P
Sbjct: 42 SENLYGKVVLITGASSGIGEQLAYEY--ACRGACLALTARRKNRLEEVAEIARELGSP-- 97
Query: 68 KVYIGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTN 127
V DV++ + + +D+ F +D L+NNAG S K ++DTN
Sbjct: 98 NVVTVHADVSKPDDCRRIVDDTITHFGRLDHLVNNAGMTQISMFENIEDITRTKAVLDTN 157
Query: 128 VVALINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKELI 187
+ T+A LP + N G IV + S A P S Y ASK A+ +F +++R EL
Sbjct: 158 FWGSVYTTRAALPYLRQSN-GKIVAMSSSAAWLTAPRMSFYNASKAALLSFFETMRIEL- 215
Query: 188 NTGIRVIEIAPGNVETEFSLVRY 210
+ + + PG +E+E + +Y
Sbjct: 216 GGDVHITIVTPGYIESELTQGKY 238
>At5g50600 [Q] KOG1205 Predicted dehydrogenase
Length = 349
Score = 74.7 bits (182), Expect = 1e-13
Identities = 59/203 (29%), Positives = 89/203 (43%), Gaps = 6/203 (2%)
Query: 8 AERLQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQA 67
+E L K + ITGAS+GIG+ A EY A G P
Sbjct: 42 SENLYGKVVLITGASSGIGEQLAYEY--ACRGACLALTARRKNRLEEVAEIARELGSP-- 97
Query: 68 KVYIGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTN 127
V DV++ + + +D+ F +D L+NNAG S K ++DTN
Sbjct: 98 NVVTVHADVSKPDDCRRIVDDTITHFGRLDHLVNNAGMTQISMFENIEDITRTKAVLDTN 157
Query: 128 VVALINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKELI 187
+ T+A LP + N G IV + S A P S Y ASK A+ +F +++R EL
Sbjct: 158 FWGSVYTTRAALPYLRQSN-GKIVAMSSSAAWLTAPRMSFYNASKAALLSFFETMRIEL- 215
Query: 188 NTGIRVIEIAPGNVETEFSLVRY 210
+ + + PG +E+E + +Y
Sbjct: 216 GGDVHITIVTPGYIESELTQGKY 238
>7300731 [Q] KOG1205 Predicted dehydrogenase
Length = 250
Score = 74.3 bits (181), Expect = 2e-13
Identities = 67/252 (26%), Positives = 110/252 (43%), Gaps = 19/252 (7%)
Query: 10 RLQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKV 69
R N+ +TGASAGIG A + + A G V A+
Sbjct: 3 RWLNRVAVVTGASAGIGAACCRDLV--AKGMVVVGLARREKVLQDIKSSLPADQ--AARF 58
Query: 70 YIGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNVV 129
+ DV+ +++ + D+L+NNAG ++ +S D++ ++D NV+
Sbjct: 59 HTRPCDVSNEQQVIDTFAWIDRTLGGADVLVNNAGIIRQMNITDPENSADVRAILDVNVL 118
Query: 130 ALINVT-QAVLPIFKAK-NSGDIVNLGSVAGRDAYPTG----SIYCASKHAVRAFTQSLR 183
+ T Q L + + K N G +V + SV G ++Y SKHA+ A T+ LR
Sbjct: 119 GVTWCTRQWFLSLQRRKVNDGHVVVINSVVGHSVPAVEGFSLNMYAPSKHAITALTEILR 178
Query: 184 KELINTG--IRVIEIAPGNVETEFSLVRYKGDADRAKQVYKGTTPLYADDIADLIVYATS 241
+E I G ++ I+PG V TE +A +Q G L ++DIAD + Y
Sbjct: 179 QEFIKKGTQTKITSISPGVVATEIF------EAGSWEQP-TGMPMLRSEDIADAVTYCIQ 231
Query: 242 RKPNTVIADVLV 253
P I ++++
Sbjct: 232 TPPTVQIKELII 243
>Hs20475206 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 305
Score = 73.9 bits (180), Expect = 2e-13
Identities = 55/194 (28%), Positives = 88/194 (45%), Gaps = 9/194 (4%)
Query: 16 IFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKVYIGQLD 75
+ ITGA GIG+ T E+ + V A Y+ +D
Sbjct: 39 VLITGAGHGIGRQTTYEFAKRQSILVLWDINKRGVEETAAECRKLGVT---AHAYV--VD 93
Query: 76 VTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNVVALINVT 135
+ E+I ++ + +E D+ I++NNAG +D++ T E+I + N++ +T
Sbjct: 94 CSNREEIYRSLNQVKKEVGDVTIVVNNAGTVYPADLLST-KDEEITKTFEVNILGHFWIT 152
Query: 136 QAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKELI---NTGIR 192
+A+LP +N G IV + SV G + P YC+SK A F + L EL TGI+
Sbjct: 153 KALLPSMMERNHGHIVTVASVCGHEGIPYLIPYCSSKFAAVGFHRGLTSELQALGKTGIK 212
Query: 193 VIEIAPGNVETEFS 206
+ P V T F+
Sbjct: 213 TSCLCPVFVNTGFT 226
>7296705 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 257
Score = 73.9 bits (180), Expect = 2e-13
Identities = 60/194 (30%), Positives = 89/194 (44%), Gaps = 8/194 (4%)
Query: 12 QNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKVYI 71
++K I +TGAS+GIG T++ L G + P +V
Sbjct: 5 KDKVIIVTGASSGIGAGTSV-LLAKLGGLLTIVGRNLDKLNETAEQIVAAGGAPALQV-- 61
Query: 72 GQLDVTETEKIQPFIDNLPEEFKDIDILINNAG-KALGSDVVGTISSEDIKGMIDTNVVA 130
D+ +Q + + ID+L+NNAG LGS + S E +++TNV +
Sbjct: 62 -AADINSESDVQGIVSATLAKHGRIDVLVNNAGILELGS--IENTSLEQFDRVMNTNVRS 118
Query: 131 LINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKELINTG 190
L +T V P K G+IVN+ SV G ++P Y SK AV FT+ + EL G
Sbjct: 119 LYQLTHLVTPEL-IKTKGNIVNVSSVNGIRSFPGVLAYNVSKAAVDQFTRCVALELAPKG 177
Query: 191 IRVIEIAPGNVETE 204
+RV + PG + TE
Sbjct: 178 VRVNSVNPGVIITE 191
>CE27260 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 206
Score = 73.6 bits (179), Expect = 3e-13
Identities = 55/186 (29%), Positives = 86/186 (45%), Gaps = 4/186 (2%)
Query: 18 ITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKVYIGQLDVT 77
+TGAS+GIG+A AL L A N + V + +++
Sbjct: 6 VTGASSGIGRAAAL--LLARNNYKLSLTGRNVAALNELAGQIVSAGSDKNDVLVTAVELA 63
Query: 78 ETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNVVALINVTQA 137
E + +D ++F ID LIN+AG V+ + E +++ NV +LI +T+A
Sbjct: 64 SEEAPKTIVDATVQKFGRIDTLINSAGILRAGPVLDS-GIEVYDELMNVNVRSLIRLTRA 122
Query: 138 VLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKELINTGIRVIEIA 197
LP G +VN+ S+ G + + YC SK AV FT+ L E+ G+RV +
Sbjct: 123 ALPHI-ITTKGTVVNVSSINGPCPFAGVTYYCMSKSAVDQFTKCLALEMAPNGVRVNAVC 181
Query: 198 PGNVET 203
PG + T
Sbjct: 182 PGVIVT 187
>CE05726 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 277
Score = 73.6 bits (179), Expect = 3e-13
Identities = 59/198 (29%), Positives = 86/198 (42%), Gaps = 5/198 (2%)
Query: 10 RLQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKV 69
R K++ ITG+S GIG++ A+ + A G P K+
Sbjct: 3 RFSGKSVIITGSSNGIGRSAAVIF--AKEGAQVTITGRNEDRLEETKQQILKAGVPAEKI 60
Query: 70 YIGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDI-KGMIDTNV 128
DVTE I+ +F IDIL+NNAG L T ++ + N
Sbjct: 61 NAVVADVTEASGQDDIINTTLAKFGKIDILVNNAGANLADGTANTDQPVELYQKTFKLNF 120
Query: 129 VALINVTQAVLPIFKAKNSGDIVNLGS-VAGRDAYPTGSIYCASKHAVRAFTQSLRKELI 187
A+I +TQ K G+IVN+ S VAG A+ Y +K A+ +T+ +LI
Sbjct: 121 QAVIEMTQKTKEHL-IKTKGEIVNVSSIVAGPQAHSGYPYYACAKAALDQYTRCTAIDLI 179
Query: 188 NTGIRVIEIAPGNVETEF 205
G+RV ++PG V T F
Sbjct: 180 QHGVRVNSVSPGAVATGF 197
>CE03132 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 278
Score = 73.6 bits (179), Expect = 3e-13
Identities = 65/217 (29%), Positives = 100/217 (45%), Gaps = 7/217 (3%)
Query: 9 ERLQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAK 68
+R K ITG+S+GIG+ TAL L A G ++
Sbjct: 3 KRFSKKVAIITGSSSGIGRETAL--LFAKEGAKVTVTGRSEEKLEETKKALLDAGIKESN 60
Query: 69 VYIGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKG---MID 125
I D+T + I ++F I+IL+NNAG ++ T + I+ ++
Sbjct: 61 FLIVPADITFSTGQDELISQTLKKFGRINILVNNAGASIPDAKKRTGIDQGIETYEQVMK 120
Query: 126 TNVVALINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGS-IYCASKHAVRAFTQSLRK 184
NV ++I +TQ V P AK+ G+IVN+ SV A T + Y +K A+ +T+S
Sbjct: 121 LNVQSVIEMTQKVRPHL-AKSRGEIVNVSSVVALKAGWTRTPYYPLAKAALDQYTRSAAI 179
Query: 185 ELINTGIRVIEIAPGNVETEFSLVRYKGDADRAKQVY 221
LI+ GIRV + PG V+T F +D A++ Y
Sbjct: 180 ALISEGIRVNTVNPGIVQTGFQANASGSSSDDAQKFY 216
>Hs4504501_1 [Q] KOG1205 Predicted dehydrogenase
Length = 244
Score = 72.8 bits (177), Expect = 5e-13
Identities = 56/198 (28%), Positives = 85/198 (42%), Gaps = 18/198 (9%)
Query: 16 IFITGASAGIGQATALEYL-DAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKVYIGQL 74
+ ITG S+GIG A+ D + P + QL
Sbjct: 6 VLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLETLQL 65
Query: 75 DVTETEKIQPFIDNLPEEFKDIDILINNAG-------KALGSDVVGTISSEDIKGMIDTN 127
DV +++ + + + E +D+L+ NAG +ALG D V ++ +D N
Sbjct: 66 DVRDSKSVAAARERVTEG--RVDVLVCNAGLGLLGPLEALGEDAVASV--------LDVN 115
Query: 128 VVALINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKELI 187
VV + + QA LP K + SG ++ GSV G P +YCASK A+ +SL L+
Sbjct: 116 VVGTVRMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLL 175
Query: 188 NTGIRVIEIAPGNVETEF 205
G+ + I G V T F
Sbjct: 176 PFGVHLSLIECGPVHTAF 193
>CE15574 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 279
Score = 72.4 bits (176), Expect = 6e-13
Identities = 75/269 (27%), Positives = 122/269 (44%), Gaps = 26/269 (9%)
Query: 10 RLQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKV 69
R K +TG+S GIG+ATA+ L A G P+ V
Sbjct: 3 RFSGKVALVTGSSNGIGRATAI--LLAREGAKVTITGRNAQRLEETKQEILRSGVPEDHV 60
Query: 70 YIGQLDV-TETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNV 128
D+ TE+ +I+ +++ + F +DIL+NNAG A+ +D+ G I + D +
Sbjct: 61 LSIIADLATESGQIE-LMNSTVDIFGRLDILVNNAGAAI-TDLEGHIGVGTNVSVFDKTM 118
Query: 129 VALINVTQAVLPIFKAKN-----SGDIVNLGSVAG-RDAYPTGSIYCASKHAVRAFTQSL 182
IN+ V KAK G+IVN+ S+AG + A P Y SK A+ +T+S
Sbjct: 119 --RINLRSVVTLTQKAKEHLIKTKGEIVNVSSIAGGQHAQPELIYYAMSKSALDQYTRSA 176
Query: 183 RKELINTGIRVIEIAPGNVETEFSLVRYKG-DADRAKQVYKGT----------TPLYADD 231
+LI G+RV ++PG++ T + G + + + +YK T D
Sbjct: 177 AIDLIQHGVRVNSVSPGDIRT--GIYETMGMNKESVENIYKFMESRKECCPIGTIAQPVD 234
Query: 232 IADLIVYATSRKPNTVIADVLVFASNQAS 260
+A++IV+ RK ++ I + A +S
Sbjct: 235 VANIIVFLADRKLSSYIIGQSIVADGGSS 263
>At5g50690 [Q] KOG1205 Predicted dehydrogenase
Length = 303
Score = 72.4 bits (176), Expect = 6e-13
Identities = 59/200 (29%), Positives = 88/200 (43%), Gaps = 6/200 (3%)
Query: 3 QGRKAAERLQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXX 62
+G K +E++ K + ITG+S+GIG+ A EY A G
Sbjct: 37 RGCKESEKVNGKVVIITGSSSGIGEHLAYEY--ARRGAYLTLVARREDRLQVVADRCRKL 94
Query: 63 XYPQAKVYIGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKG 122
P V G DV+ + + F+ F +D L+NNAG A D+
Sbjct: 95 GSPDVAVVRG--DVSVIKDCKRFVQETISRFGRLDHLVNNAGIAEAKFFEDYSEISDVLP 152
Query: 123 MIDTNVVALINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSL 182
+++TN + T +P K K G I+ + S AG P SIY ASK A+ F ++L
Sbjct: 153 IVNTNFWGPVYATHFAIPHLK-KTKGKIIAVASPAGWSGVPRMSIYAASKAAMINFYETL 211
Query: 183 RKELINTGIRVIEIAPGNVE 202
R EL + + V + PG +E
Sbjct: 212 RIEL-HPEVGVTIVFPGLIE 230
>At5g50590 [Q] KOG1205 Predicted dehydrogenase
Length = 299
Score = 72.4 bits (176), Expect = 6e-13
Identities = 59/200 (29%), Positives = 88/200 (43%), Gaps = 6/200 (3%)
Query: 3 QGRKAAERLQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXX 62
+G K +E++ K + ITG+S+GIG+ A EY A G
Sbjct: 37 RGCKESEKVNGKVVIITGSSSGIGEHLAYEY--ARRGAYLTLVARREDRLQVVADRCRKL 94
Query: 63 XYPQAKVYIGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKG 122
P V G DV+ + + F+ F +D L+NNAG A D+
Sbjct: 95 GSPDVAVVRG--DVSVIKDCKRFVQETISRFGRLDHLVNNAGIAEAKFFEDYSEISDVLP 152
Query: 123 MIDTNVVALINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSL 182
+++TN + T +P K K G I+ + S AG P SIY ASK A+ F ++L
Sbjct: 153 IVNTNFWGPVYATHFAIPHLK-KTKGKIIAVASPAGWSGVPRMSIYAASKAAMINFYETL 211
Query: 183 RKELINTGIRVIEIAPGNVE 202
R EL + + V + PG +E
Sbjct: 212 RIEL-HPEVGVTIVFPGLIE 230
>At3g47360 [Q] KOG1205 Predicted dehydrogenase
Length = 309
Score = 72.4 bits (176), Expect = 6e-13
Identities = 64/204 (31%), Positives = 89/204 (43%), Gaps = 18/204 (8%)
Query: 9 ERLQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAK 68
E + K + ITGAS+GIG+ A EY A G
Sbjct: 43 ENVARKVVLITGASSGIGEHVAYEY--AKKG--AYLALVARRRDRLEIVAETSRQLGSGN 98
Query: 69 VYIGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNV 128
V I DV+ E + FID F +D LINNAG V T+ ED + D N
Sbjct: 99 VIIIPGDVSNVEDCKKFIDETIRHFGKLDHLINNAG------VFQTVLFEDFTQIQDANP 152
Query: 129 VALIN------VTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSL 182
+ IN +T +P + K+ G IV + S + P SIY ASK A+ F ++L
Sbjct: 153 IMDINFWGTTYITYFAIPHLR-KSKGKIVAITSGSANIPLPLASIYAASKAALLRFFETL 211
Query: 183 RKELINTGIRVIEIAPGNVETEFS 206
R EL + I++ + PG V T+ +
Sbjct: 212 RIEL-SPDIKITIVLPGVVSTDMT 234
>CE20725 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 279
Score = 72.0 bits (175), Expect = 8e-13
Identities = 60/202 (29%), Positives = 88/202 (42%), Gaps = 11/202 (5%)
Query: 10 RLQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKV 69
R K ITG+S GIG+A A+ L A G P +
Sbjct: 3 RFSGKVALITGSSNGIGRAAAI--LFAQQGAKVTITGRNAERLKETRHEIKKSGIPAENI 60
Query: 70 YIGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNVV 129
DV E I++ +F +DIL+NNAG AL D G + + + D +
Sbjct: 61 LAIVADVITDEGQMRLINDTVRKFGHLDILVNNAGGAL-MDAQGRVGMDQDISVFDNTMQ 119
Query: 130 ALINVTQAVLPIFKAK-----NSGDIVNLGSVA-GRDAYPTGSIYCASKHAVRAFTQSLR 183
IN+ V + KAK + G+I+N+ ++A G P + Y SK A+ FT+S
Sbjct: 120 --INMRSVVTLVQKAKEHLIKSKGEIINVSAMAAGHHGDPIATFYGMSKAALDQFTRSSA 177
Query: 184 KELINTGIRVIEIAPGNVETEF 205
LI G+RV ++PG +T F
Sbjct: 178 ISLIQHGVRVNSVSPGFTKTGF 199
>7296047 [Q] KOG1205 Predicted dehydrogenase
Length = 321
Score = 72.0 bits (175), Expect = 8e-13
Identities = 51/205 (24%), Positives = 98/205 (46%), Gaps = 6/205 (2%)
Query: 11 LQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAK-V 69
++ + ++ITGAS+GIG+A AL V K V
Sbjct: 44 MRGQVVWITGASSGIGRALALSLARHGVKLVLSARRLEQLEQVQEECLAAARGLLATKDV 103
Query: 70 YIGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNVV 129
+ Q+D+ + ++ + ++ + F +D+L+NNAG++ + + E + + + +V
Sbjct: 104 LVIQMDMLDLDEHKTHLNTVLNHFHRLDVLVNNAGRSQRASWT-EVEIEVDRELFELDVF 162
Query: 130 ALINVTQAVLPIFKAKNSG--DIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKELI 187
A++++++ V+ F +N G I S+AG P YCA+KHA+ A+ SL+ E+
Sbjct: 163 AVVHLSRLVVRYFVEQNGGRGHIAATSSIAGFSPVPFSPTYCAAKHALNAYLLSLKVEMR 222
Query: 188 NTGIRVIEIAPGNVETEFSLVRYKG 212
+ + APG + T+F + G
Sbjct: 223 KLDVSL--FAPGPIATDFLQEAFTG 245
>7294452 [Q] KOG1205 Predicted dehydrogenase
Length = 266
Score = 71.6 bits (174), Expect = 1e-12
Identities = 65/259 (25%), Positives = 119/259 (45%), Gaps = 29/259 (11%)
Query: 9 ERLQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAK 68
ER NK ++GASAGIG A + A V Q++
Sbjct: 16 ERWCNKVAVVSGASAGIGAACTRALIGAGMIVVGLARRHERVEKLRSGLSLEQ----QSR 71
Query: 69 VYIGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSED----IKGMI 124
++ + D+T+ +++ D + +D+L++NAG +G+ G +S D ++ I
Sbjct: 72 LHAIKCDITQEDQVLKAFDWTCRQLGGVDVLVSNAG-IIGT---GELSERDDGPAMRSTI 127
Query: 125 DTNVVALINVTQAVLPIFKAKNS-GDIVNLGSVAGRDA------YPTGSIYCASKHAVRA 177
+TN++ + + K + + G +V + SVAG P+ +IY A+K A+RA
Sbjct: 128 ETNIMGTVYCVRESFRSMKRRGTEGHVVIVNSVAGYQVPNLGPQLPSLNIYPATKFALRA 187
Query: 178 FTQSLRKEL--INTGIRVIEIAPGNVETEFSLVRYKGDADRAKQVYKGTTP-LYADDIAD 234
+ R+E T +RV ++PG V+T + +G + K P L +DD+AD
Sbjct: 188 MNEIYRQEFQRHKTAVRVSTVSPGIVDTVILPEQIQG-------IIKQHMPMLRSDDVAD 240
Query: 235 LIVYATSRKPNTVIADVLV 253
+++A PN + ++ +
Sbjct: 241 AVLWAIGTPPNVQVHNITI 259
>7292690 [Q] KOG1205 Predicted dehydrogenase
Length = 251
Score = 71.2 bits (173), Expect = 1e-12
Identities = 70/256 (27%), Positives = 114/256 (44%), Gaps = 24/256 (9%)
Query: 9 ERLQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAK 68
+R N+ +TGAS+GIG A + + + G V QA
Sbjct: 2 DRWLNRVAVVTGASSGIGAACCKDLV--SKGLVVVGLARREDRLQELKASLPAD---QAS 56
Query: 69 VYIGQ-LDVTETEKIQPFIDNLPEEFKDIDILINNAGKA-LGSDVVGTISSEDIKGMIDT 126
+ G+ DV++ +++ + D+L+NNAG LG + + D++ ++DT
Sbjct: 57 RFHGRKCDVSQEQEVIDAFAWIDATLGGADVLVNNAGIVRLGVGITHEGNGADLRAILDT 116
Query: 127 NVVALINVTQAVLPIFKAKN--SGDIVNLGSVAGRDAYP----TGSIYCASKHAVRAFTQ 180
NV+ + T+ K +N G I+ + SVAG T +Y SK+AV A T+
Sbjct: 117 NVLGVSWCTREAFKSLKRRNVNDGHILIVNSVAGHRVINNPGITMGMYSPSKYAVTALTE 176
Query: 181 SLRKELIN--TGIRVIEIAPGNVETEFSLVRYKGDADRAKQVYKGTTP-LYADDIADLIV 237
LR+E N T ++ I+PG V+TE D+ V P L ++D+AD I
Sbjct: 177 VLRQEFHNNKTQTKITSISPGAVDTEI--------IDKEALVGIPDFPMLRSEDVADAIS 228
Query: 238 YATSRKPNTVIADVLV 253
Y PN I ++ +
Sbjct: 229 YCIQTPPNVQIHELTI 244
>Hs14735093 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 319
Score = 70.5 bits (171), Expect = 2e-12
Identities = 62/207 (29%), Positives = 95/207 (44%), Gaps = 14/207 (6%)
Query: 3 QGRKAAERLQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXX 62
+G+ E + +K IFITG +G G A + D +V
Sbjct: 19 KGKLKIEDITDKYIFITGCDSGFGNLAARTF-DKKGFHVIAACLTESGSTALKAET---- 73
Query: 63 XYPQAKVYIGQLDVTETEKIQ---PFIDNLPEEFKDIDILINNAGKALGSDVVGTISSED 119
++ LDVT+ E ++ ++ N E K + LINNAG ++ ED
Sbjct: 74 ---SERLRTVLLDVTDPENVKRTAQWVKNQVGE-KGLWGLINNAGVPGVLAPTDWLTLED 129
Query: 120 IKGMIDTNVVALINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFT 179
+ I+ N+ LI+VT +LP+ K K G ++N+ SV GR A G Y SK+AV F
Sbjct: 130 YREPIEVNLFGLISVTLNMLPLVK-KAQGRVINVSSVGGRLAI-VGGGYTPSKYAVEGFN 187
Query: 180 QSLRKELINTGIRVIEIAPGNVETEFS 206
SLR+++ G+ V I PG +T +
Sbjct: 188 DSLRRDMKAFGVHVSCIEPGLFKTNLA 214
>Hs10047132 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 245
Score = 70.1 bits (170), Expect = 3e-12
Identities = 68/239 (28%), Positives = 108/239 (44%), Gaps = 22/239 (9%)
Query: 10 RLQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKV 69
RL K I +T A+ GIGQA AL + A G YP +
Sbjct: 3 RLDGKVIILTAAAQGIGQAAALAF--AREG------AKVIATDINESKLQELEKYPGIQT 54
Query: 70 YIGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNVV 129
+ LDVT+ ++I F + E + +D+L N AG V+ +D ++ NV
Sbjct: 55 RV--LDVTKKKQIDQFAN----EVERLDVLFNVAGFVHHGTVLDC-EEKDWDFSMNLNVR 107
Query: 130 ALINVTQAVLPIFKAKNSGDIVNLGSVAGR-DAYPTGSIYCASKHAVRAFTQSLRKELIN 188
++ + +A LP A+ SG+I+N+ SVA +Y +K AV T+S+ + I
Sbjct: 108 SMYLMIKAFLPKMLAQKSGNIINMSSVASSVKGVVNRCVYSTTKAAVIGLTKSVAADFIQ 167
Query: 189 TGIRVIEIAPGNVETEF--SLVRYKGDADRAKQVY----KGTTPLYADDIADLIVYATS 241
GIR + PG V+T ++ +G+ + A+ + K A++IA L VY S
Sbjct: 168 QGIRCNCVCPGTVDTPSLQERIQARGNPEEARNDFLKRQKTGRFATAEEIAMLCVYLAS 226
>7290108 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 270
Score = 70.1 bits (170), Expect = 3e-12
Identities = 55/189 (29%), Positives = 87/189 (45%), Gaps = 11/189 (5%)
Query: 11 LQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKVY 70
L NK + +TGAS+GIG A A + A G QA++
Sbjct: 3 LSNKVVIVTGASSGIGAAIA--QVLAREGATLALVGRNVANLEATKKSLKGT---QAEIV 57
Query: 71 IGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNVVA 130
+ + T+ + +F ID+L+NNAG LG + + E+ +++TN+
Sbjct: 58 VADV----TKDADAIVQQTLAKFGRIDVLVNNAG-ILGKGGLIDLDIEEFDAVLNTNLRG 112
Query: 131 LINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKELINTG 190
+I +T+AVLP K G +VN+ S AG + Y SK A+ FT+ + E+ G
Sbjct: 113 VILLTKAVLPHL-LKTKGAVVNVSSCAGIRPFAGALSYGVSKAALDQFTKIVALEMAPQG 171
Query: 191 IRVIEIAPG 199
+RV + PG
Sbjct: 172 VRVNSVNPG 180
>7296706_2 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 233
Score = 69.3 bits (168), Expect = 5e-12
Identities = 45/132 (34%), Positives = 68/132 (51%), Gaps = 2/132 (1%)
Query: 73 QLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNVVALI 132
Q D+T+ ++Q + + ID+L+NNAG L + + S E +++TNV +L
Sbjct: 38 QADMTKEAEVQQIVGATLAKHGRIDVLVNNAG-ILETGSIEATSLEQFDRLMNTNVRSLY 96
Query: 133 NVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKELINTGIR 192
+T P K G+IVN+ SV G A+P Y SK AV FT + EL G+R
Sbjct: 97 QLTMLATPEL-VKTKGNIVNVSSVCGLRAFPGVLAYNVSKAAVDQFTACIALELAPKGVR 155
Query: 193 VIEIAPGNVETE 204
V + PG + T+
Sbjct: 156 VNAVNPGVIVTD 167
>At3g47350 [Q] KOG1205 Predicted dehydrogenase
Length = 308
Score = 68.6 bits (166), Expect = 9e-12
Identities = 62/209 (29%), Positives = 89/209 (41%), Gaps = 18/209 (8%)
Query: 9 ERLQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAK 68
E + K + ITGAS+GIG+ A EY A G
Sbjct: 42 ENVTGKVVLITGASSGIGEHVAYEY--AKKG--AKLALVARRKDRLEIVAETSRQLGSGD 97
Query: 69 VYIGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNV 128
V I DV+ E + FID F +D LINNAG V T+ ED + D N
Sbjct: 98 VIIIPGDVSNVEDCKKFIDETIHHFGKLDHLINNAG------VPQTVIFEDFTQIQDANS 151
Query: 129 VALIN------VTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSL 182
+ IN +T +P + K+ G IV + S S+Y ASK A+ F ++L
Sbjct: 152 IMDINFWGSTYITYFAIPHLR-KSKGKIVVISSATAIIPLQAASVYSASKAALVKFFETL 210
Query: 183 RKELINTGIRVIEIAPGNVETEFSLVRYK 211
R E I+ I++ PG + T+ + ++K
Sbjct: 211 RVE-ISPDIKITIALPGFISTDMTTPQFK 238
>CE26808_2 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 550
Score = 68.6 bits (166), Expect = 9e-12
Identities = 60/202 (29%), Positives = 88/202 (42%), Gaps = 11/202 (5%)
Query: 10 RLQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKV 69
R K +TG+S GIG+A AL L A G P V
Sbjct: 218 RFSGKVALVTGSSNGIGRAAAL--LFAQQGAKVTITGRNAERLEETRQAILKSGVPAENV 275
Query: 70 YIGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNVV 129
D+ + I+ ++F +DIL+NNAG A+ +D G + + + + D +
Sbjct: 276 LAIAADLATDQGQTDLINGTLQKFGRLDILVNNAGAAV-NDPQGRMGID--QQIEDFDKT 332
Query: 130 ALINVTQAVLPIFKAKN-----SGDIVNLGSVAGRD-AYPTGSIYCASKHAVRAFTQSLR 183
IN+ V + KAK G+I+N+ S+ G A P Y SK A+ FT+S
Sbjct: 333 FQINMRSVVTLVQKAKEHLIKTKGEIINVSSIGGGPHAQPDMMYYGMSKAALDQFTRSTA 392
Query: 184 KELINTGIRVIEIAPGNVETEF 205
LI G+RV ++PG V T F
Sbjct: 393 ITLIQHGVRVNSVSPGGVYTGF 414
>At1g07440 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 266
Score = 68.2 bits (165), Expect = 1e-11
Identities = 60/217 (27%), Positives = 94/217 (42%), Gaps = 8/217 (3%)
Query: 11 LQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKVY 70
L+ KT+ +TG + GIG A E+ A G V +
Sbjct: 12 LKAKTVLVTGGTKGIGHAIVEEF--AGFGAVIHTCARNEYELNECLSKWQKKGFQVTGSV 69
Query: 71 IGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNVVA 130
E EK+ + ++ +DILINN G A+ S ++ED I TN+ +
Sbjct: 70 CDASLRPEREKLMQTVSSMFGG--KLDILINNLG-AIRSKPTLDYTAEDFSFHISTNLES 126
Query: 131 LINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKELINTG 190
+++Q P+ KA G+I+ + S+AG + GSIY A+K A+ ++L E + G
Sbjct: 127 AYHLSQLAHPLLKASGCGNIIFMSSIAGVVSASVGSIYSATKGALNQLARNLACEWASDG 186
Query: 191 IRVIEIAPGNVETEFSLVRYKGDADRAKQVYKGTTPL 227
IR +AP + T + Y D K+V PL
Sbjct: 187 IRANAVAPAVIATPLAEAVYD---DEFKKVVISRKPL 220
>Hs18582884 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 316
Score = 67.8 bits (164), Expect = 2e-11
Identities = 58/213 (27%), Positives = 91/213 (42%), Gaps = 20/213 (9%)
Query: 10 RLQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKV 69
+L K + ITGA+ GIG+ TA E A+ ++V
Sbjct: 36 QLPGKVVVITGANTGIGKETAREL---ASRGARVYIACRDVLKGESAASEIRVDTKNSQV 92
Query: 70 YIGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNVV 129
+ +LD+++T+ I+ F + E K + ILINNAG + + +++ + + N +
Sbjct: 93 LVRKLDLSDTKSIRAFAEGFLAEEKQLHILINNAGVMM---CPYSKTADGFETHLGVNHL 149
Query: 130 ALINVTQAVLPIFKAKNSGDIVNLGSVA------------GRDAYPTGSIYCASKHAVRA 177
+T +L K +VN+ SVA Y G YC SK A
Sbjct: 150 GHFLLTYLLLERLKVSAPARVVNVSSVAHHIGKIPFHDLQSEKRYSRGFAYCHSKLANVL 209
Query: 178 FTQSLRKELINTGIRVIEIAPGNVETEFSLVRY 210
FT+ L K L TG+ + PG V +E LVR+
Sbjct: 210 FTRELAKRLQGTGVTTYAVHPGVVRSE--LVRH 240
>7293522 [Q] KOG1207 Diacetyl reductase/L-xylulose reductase
Length = 242
Score = 67.4 bits (163), Expect = 2e-11
Identities = 55/194 (28%), Positives = 89/194 (45%), Gaps = 15/194 (7%)
Query: 11 LQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKVY 70
L K I +TGA AGIGQA + A + +
Sbjct: 5 LAGKVILVTGAGAGIGQALVKQLASAG--------ATVIAVARKPEQLQQLVAFDPVHIQ 56
Query: 71 IGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNVVA 130
QLD++ + ++ + +P +D L+NNAG A+ ++ +D D N+ A
Sbjct: 57 PLQLDLSGWQAVREGLAKVPL----LDGLVNNAGVAIIKPFE-ELTEQDFDTHFDVNIKA 111
Query: 131 LINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKELINTG 190
+ NVTQ++LP + K+ IVN+ S+A ++ + Y A+K A+ + T+SL EL
Sbjct: 112 VFNVTQSLLP--RLKDGASIVNVSSIASSRSFGGHTAYSATKAALDSLTKSLALELGPRK 169
Query: 191 IRVIEIAPGNVETE 204
IRV + P V T+
Sbjct: 170 IRVNSVNPTVVLTK 183
>SPCC162.03 [Q] KOG1205 Predicted dehydrogenase
Length = 292
Score = 67.0 bits (162), Expect = 3e-11
Identities = 57/197 (28%), Positives = 93/197 (46%), Gaps = 21/197 (10%)
Query: 15 TIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKVYIGQL 74
T+ ITG+S G+G A L A NV +K+ +L
Sbjct: 7 TVLITGSSKGLGYALVKVGL-AQGYNVIACSRAPDTITIE-----------HSKLLKLKL 54
Query: 75 DVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGM---IDTNVVAL 131
DVT+ + ++ + F ++DI+INNAG L VG S +I+ M ++ N +
Sbjct: 55 DVTDVKSVETAFKDAKRRFGNVDIVINNAGYGL----VGEFESYNIEEMHRQMNVNFWGV 110
Query: 132 INVTQAVLPIFKAKNSGD-IVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKEL-INT 189
+T+ L + + G I+ + SVAG P S+Y ASK AV +Q++ +EL N
Sbjct: 111 AYITKEALNLMRESGKGGRILQISSVAGYYPSPCLSMYNASKFAVEGLSQTIMRELDPNW 170
Query: 190 GIRVIEIAPGNVETEFS 206
I + + PG ++TE++
Sbjct: 171 NIAITIVQPGGMQTEWA 187
>Hs4506463 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 318
Score = 67.0 bits (162), Expect = 3e-11
Identities = 54/193 (27%), Positives = 87/193 (44%), Gaps = 12/193 (6%)
Query: 13 NKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKVYIG 72
N +FITG +G G+ AL+ LD + V
Sbjct: 28 NAFVFITGCDSGFGRLLALQ-LDQKSFRVLASCLTPSGAEDLQGVASSGFNTTL------ 80
Query: 73 QLDVTETEKIQPFIDNLPEEFKDIDI--LINNAGKALGSDVVGTISSEDIKGMIDTNVVA 130
LD+T+ + Q + K+ + L+NNAG A ++ +D + +++ N +
Sbjct: 81 -LDITDPQSFQQAAKWVEMHVKEAGLFGLVNNAGVAGIIGPTPWLTRDDFQRVLNVNTMG 139
Query: 131 LINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKELINTG 190
I VT A+LP+ + G ++N+ SV GR A G YC SK + AF+ SLR+++ + G
Sbjct: 140 PIGVTLALLPLLQQAR-GRVINITSVLGRLA-ANGGGYCVSKFGLEAFSDSLRRDVAHFG 197
Query: 191 IRVIEIAPGNVET 203
IR + PG T
Sbjct: 198 IRESIVEPGFFRT 210
>CE06649 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 284
Score = 67.0 bits (162), Expect = 3e-11
Identities = 68/256 (26%), Positives = 111/256 (42%), Gaps = 22/256 (8%)
Query: 10 RLQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKV 69
R K + I+G+S GIGQATA+++ AA G +
Sbjct: 5 RFSGKVVLISGSSKGIGQATAVKF--AAEGAKIVLNGRSADDVEKTRKLCMEVGAKPWDL 62
Query: 70 YIGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMID---- 125
D+T + ++ ++ + F +DILINNAG L D+ G E ++D
Sbjct: 63 LPTVGDITNEDFVKMMVNTVIHNFGKLDILINNAG-TLEVDMTGKEGWEMGVDVMDRSWN 121
Query: 126 TNVVALINVTQAVLPIFKAKNSGDIVNLGSV--AGRDAYPTGSIYCASKHAVRAFTQSLR 183
+N +++ +TQA +P K GDIVN+ + +G + Y K A+ ++S+
Sbjct: 122 SNFKSVLMLTQAAMP-HLIKTKGDIVNVSTFLSSGPIGVMSMPYYAVPKAALDQMSRSMA 180
Query: 184 KELINTGIRVIEIAPGNVETEFSLVRYKGDAD---RAKQVYKGTTPLY--------ADDI 232
E + G+R+ + PG V T F R G D R + Y + Y A D+
Sbjct: 181 HEYMLKGVRLNTVNPGLVSTSF-FARLPGVGDDNARKMENYVQSKTEYIPLGRVCQASDV 239
Query: 233 ADLIVYATSRKPNTVI 248
A+ I++ RK + I
Sbjct: 240 AETILFLADRKVSECI 255
>At3g55310 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 298
Score = 66.6 bits (161), Expect = 3e-11
Identities = 63/227 (27%), Positives = 98/227 (42%), Gaps = 7/227 (3%)
Query: 11 LQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKVY 70
L++K + +TGAS+GIG+ L+ A + QA
Sbjct: 36 LKDKVVLVTGASSGIGREICLDLAKAGCQVIAAARRVDRLNSLCSEINSFSSTGIQAAAL 95
Query: 71 IGQLDV-TETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNVV 129
+LDV ++ IQ + + F ID LINNAG + +S ++ + +TN+
Sbjct: 96 --ELDVSSDAATIQKAVREAWDIFGKIDALINNAGIRGNVKLSLDLSEDEWDNVFNTNLK 153
Query: 130 ALINVTQAVLPIFK-AKNSGDIVNLGSVAG-RDAYPTGSIYCASKHAVRAFTQSLRKELI 187
V + V + + AK G ++N+ SVAG R P G Y SK V ++ + EL
Sbjct: 154 GPWLVAKYVCVLMRDAKRGGSVINISSVAGVRSIVPGGLAYSCSKGGVDTMSRMMAIELG 213
Query: 188 NTGIRVIEIAPGNVETEFSLVRYKGDADRAKQVYKGTTPLYADDIAD 234
IRV IAPG ++E + + + K V + T PL D
Sbjct: 214 VHKIRVNSIAPGLFKSEITQALMQ--KEWLKNVTERTVPLKVQQTID 258
>Hs20070272 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 318
Score = 66.2 bits (160), Expect = 4e-11
Identities = 57/213 (26%), Positives = 90/213 (41%), Gaps = 20/213 (9%)
Query: 10 RLQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKV 69
+L K + +TGA+ GIG+ TA E A +V
Sbjct: 38 QLPGKVVVVTGANTGIGKETAKEL---AQRGARVYLACRDVEKGELVAKEIQTTTGNQQV 94
Query: 70 YIGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNVV 129
+ +LD+++T+ I+ F E K + +LINNAG + + +++ + I N +
Sbjct: 95 LVRKLDLSDTKSIRAFAKGFLAEEKHLHVLINNAGVMM---CPYSKTADGFEMHIGVNHL 151
Query: 130 ALINVTQAVLPIFKAKNSGDIVNLGSVA------------GRDAYPTGSIYCASKHAVRA 177
+T +L K IVN+ S+A G Y G YC SK A
Sbjct: 152 GHFLLTHLLLEKLKESAPSRIVNVSSLAHHLGRIHFHNLQGEKFYNAGLAYCHSKLANIL 211
Query: 178 FTQSLRKELINTGIRVIEIAPGNVETEFSLVRY 210
FTQ L + L +G+ + PG V++E LVR+
Sbjct: 212 FTQELARRLKGSGVTTYSVHPGTVQSE--LVRH 242
>7298353 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 308
Score = 66.2 bits (160), Expect = 4e-11
Identities = 61/194 (31%), Positives = 88/194 (44%), Gaps = 14/194 (7%)
Query: 18 ITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKVYIGQLDVT 77
+TGAS GIG+ A E L N NV Q K+ I D T
Sbjct: 54 VTGASDGIGKEYAKE-LARQNINVVLIARTEEKLQAVAKEIADCGAGVQTKIVIA--DFT 110
Query: 78 ETEKIQPFID----NLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNVVALIN 133
+ ++ I+ N+P I IL+NN G A ++ + E+ + +IDTNVVA+
Sbjct: 111 KGSQVYEHIEKETANIP-----ISILVNNVGIATPKSLL-KYNQEETQNIIDTNVVAVSQ 164
Query: 134 VTQAVLPIFKA-KNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKELINTGIR 192
+++ KA K G IVN+GS P G+ Y ASK R+ T +L E GI
Sbjct: 165 LSRIFFQRMKASKLKGAIVNVGSGTELQPLPNGAYYAASKAYTRSLTLALYHEAKPYGIH 224
Query: 193 VIEIAPGNVETEFS 206
V ++P V T+ +
Sbjct: 225 VQMLSPNFVVTKIN 238
>At1g49670_1 [IR] KOG4169 15-hydroxyprostaglandin dehydrogenase and related
dehydrogenases
Length = 305
Score = 65.9 bits (159), Expect = 6e-11
Identities = 57/198 (28%), Positives = 90/198 (44%), Gaps = 12/198 (6%)
Query: 18 ITGASAGIGQATALE------YLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKVYI 71
+TG ++GIG+A L ++ A+ + +P A +++
Sbjct: 11 VTGGASGIGRALCLALAEKGVFVTVADFSEEKGQETTSLVREANAKFHQGLSFPSA-IFV 69
Query: 72 GQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKA--LGSDVVGTISSEDIKGMIDTNVV 129
+ DVT + D F +DI INNAG + L D T S+ K I+ +++
Sbjct: 70 -KCDVTNRGDLLAAFDKHLATFGTLDICINNAGISTPLRFDKDDTDGSKSWKHTINVDLI 128
Query: 130 ALINVTQAVLPIFKAKNS-GDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKELIN 188
A++ TQ + KAK G I+N+GS AG P IY ASK V FT+SL
Sbjct: 129 AVVEGTQLAIKAMKAKQKPGVIINMGSAAGLYPMPVDPIYAASKAGVVLFTRSL-AYYRR 187
Query: 189 TGIRVIEIAPGNVETEFS 206
GIR+ + P ++T+ +
Sbjct: 188 QGIRINVLCPEFIKTDLA 205
>At5g19200 [Q] KOG1210 Predicted 3-ketosphinganine reductase
Length = 331
Score = 65.5 bits (158), Expect = 8e-11
Identities = 55/192 (28%), Positives = 87/192 (44%), Gaps = 14/192 (7%)
Query: 16 IFITGASAGIGQATALEYL-DAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKVYIGQL 74
+FITG S+GIG A A + + A ++ +V
Sbjct: 40 VFITGGSSGIGLALAHRAVSEGAKVSILARSTEKLAEAKRSIQLATG-----VEVATFSA 94
Query: 75 DVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNVVALINV 134
DV + + + ID E ID+LI N G +G ++ S E++K MID N+ NV
Sbjct: 95 DVRDYDAVSKAID----ESGPIDVLIVNQGVFIGKELEKQ-SPEEVKFMIDVNLTGSFNV 149
Query: 135 TQAVLPIFKAKNS---GDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKELINTGI 191
+A LP KA+ I + S AG+ + Y ASK ++ Q+L++E+I+ GI
Sbjct: 150 IKAALPAMKAREGRGPASISLVSSQAGQAGIYGYTAYSASKFGLQGLAQALQQEVISDGI 209
Query: 192 RVIEIAPGNVET 203
V + P + +T
Sbjct: 210 HVTLLFPPDTDT 221
>At2g29170 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 268
Score = 65.5 bits (158), Expect = 8e-11
Identities = 62/246 (25%), Positives = 109/246 (44%), Gaps = 24/246 (9%)
Query: 6 KAAERLQNK--------TIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXX 57
KA E L++K T +TG S G+G+A +E L V
Sbjct: 3 KAEENLRDKCRWSLGGMTALVTGGSKGLGEAV-VEELAMLGARVHTCARNETQLQECVRE 61
Query: 58 XXXXXXYPQAKVYIGQLDVTETEKIQPFIDNLPEEFKD-IDILINNAGKALGSDVVGTIS 116
+V DV+ ++ + ++N+ F+ ++IL+NNAG + +
Sbjct: 62 WQAKGF----EVTTSVCDVSSRDQREKLMENVASIFQGKLNILVNNAGTGITKPTT-EYT 116
Query: 117 SEDIKGMIDTNVVALINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVR 176
++D ++ TN+ + +++Q P+ KA SG IV + S AG GSIY A+K A+
Sbjct: 117 AQDYSFLMATNLDSAFHLSQLAHPLLKASGSGSIVLMSSTAGVVHINVGSIYGATKGAMN 176
Query: 177 AFTQSLRKELINTGIRVIEIAPGNVETEFSLVRYKGDADRAKQVYKGTTPL----YADDI 232
++L E IRV + P + T Y D + K+V + TP+ A+++
Sbjct: 177 QLAKNLACEWARDNIRVNSVCPWFIATPL----YLNDEELKKEVER-KTPMGRVGNANEV 231
Query: 233 ADLIVY 238
+ L+ +
Sbjct: 232 SSLVAF 237
>SPAC3G9.02 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 236
Score = 64.7 bits (156), Expect = 1e-10
Identities = 51/180 (28%), Positives = 89/180 (49%), Gaps = 8/180 (4%)
Query: 72 GQLDVTETEKIQPFIDNLPEEFKDIDI-LINNAGKALGSDVVGTISSEDIKGMIDTNVVA 130
GQ +Q + NL F+ ++I + +A L S + S ++I +I TN+V+
Sbjct: 50 GQQHTLTIADVQSDMKNLKSIFESVEIDTVVHAAGVLQSSLCVRTSEKEIDSIICTNLVS 109
Query: 131 LINVTQ-AVLPIFKAKNSGD---IVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKEL 186
I +++ A+L F+ KNS I+N+ S A P S+Y ASK + +FT+ L E+
Sbjct: 110 AIKLSKMAILEWFRNKNSERDRLILNISSRLSTYALPGTSVYAASKAGLESFTKVLAAEV 169
Query: 187 INTGIRVIEIAPGNVETEFSLVRYKGDADRAKQVYKGTTPLYADDIADLIVYATSRKPNT 246
+ GIRV I+PG V+T + + A++ + + + D+I D + + T
Sbjct: 170 ASKGIRVNAISPGYVDTPMLSSQIRAIAEKKVPIGRLAS---TDEIVDACTFLLDNRYTT 226
>CE07544 [Q] KOG1205 Predicted dehydrogenase
Length = 262
Score = 64.7 bits (156), Expect = 1e-10
Identities = 56/195 (28%), Positives = 90/195 (45%), Gaps = 12/195 (6%)
Query: 11 LQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKVY 70
++NK + ITGAS+G+G++ A E L V Q +
Sbjct: 45 VKNKVVVITGASSGLGKSLAFE-LYKRGAQVILLARSTEKLKEICEELKETFPLNQNEPI 103
Query: 71 IGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNVVA 130
D+T++E+ P+ E +DILINNAG + T + E + ++TN
Sbjct: 104 YYYFDITDSEQA-PWA-----EIPRVDILINNAGMSNRGSCQDT-TMEIHRQAMETNYFG 156
Query: 131 LINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKELINTG 190
++VTQA+L K G IV S+ G+ A P Y ASKHA++ + LR E +
Sbjct: 157 HVHVTQALLS--KLSPDGCIVVTSSIQGKVAIPYRGSYGASKHALQGYFDCLRAE--HKN 212
Query: 191 IRVIEIAPGNVETEF 205
+ ++ ++ G + T F
Sbjct: 213 LHILVVSAGYINTGF 227
>7295487 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 317
Score = 64.7 bits (156), Expect = 1e-10
Identities = 53/209 (25%), Positives = 90/209 (42%), Gaps = 11/209 (5%)
Query: 9 ERLQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAK 68
+RL K +T ++ GIG A A + V K
Sbjct: 67 KRLAGKVAVVTASTDGIGFAIAKRLAEDGAAVVISSRKQKNVDSALAELRKLNLNVHGLK 126
Query: 69 VYIGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIK---GMID 125
+ V+E E + + +F ++IL++NA + VG + D K + D
Sbjct: 127 CH-----VSEPEDRKQLFEETISKFGKLNILVSNAAT---NPAVGGVLECDEKVWDKIFD 178
Query: 126 TNVVALINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKE 185
NV + + + LP+ + + + IV + S+AG DA+ Y SK A+ T++ K+
Sbjct: 179 VNVKSSYLLAKEALPLLRQQKNSSIVFVSSIAGYDAFELLGAYSVSKTALIGLTKAAAKD 238
Query: 186 LINTGIRVIEIAPGNVETEFSLVRYKGDA 214
L GIRV +APG + T+FS Y+ ++
Sbjct: 239 LAPEGIRVNCLAPGVIRTKFSKALYENES 267
>YIL124w [Q] KOG1209 1-Acyl dihydroxyacetone phosphate reductase and related
dehydrogenases
Length = 297
Score = 63.9 bits (154), Expect = 2e-10
Identities = 57/195 (29%), Positives = 83/195 (42%), Gaps = 11/195 (5%)
Query: 14 KTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKVYIGQ 73
K +TGAS GIG E A NG + K
Sbjct: 10 KIAVVTGASGGIGYEVTKEL--ARNGYLVYACARRLEPMAQLAIQFGNDSIKPYK----- 62
Query: 74 LDVTETEKIQPFIDNLPEEFKD--IDILINNAGKALGSDVVGTISSEDIKGMIDTNVVAL 131
LD+++ E+I F L D +D+L NNAG++ + + ++ NV
Sbjct: 63 LDISKPEEIVTFSGFLRANLPDGKLDLLYNNAGQSCTFPALDATDAA-VEQCFKVNVFGH 121
Query: 132 INVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKELINTGI 191
IN+ + L F K G IV GS+AG ++P GSIY ASK A+ + + L E+ +
Sbjct: 122 INMCRE-LSEFLIKAKGTIVFTGSLAGVVSFPFGSIYSASKAAIHQYARGLHLEMKPFNV 180
Query: 192 RVIEIAPGNVETEFS 206
RVI G V T+ +
Sbjct: 181 RVINAITGGVATDIA 195
>Hs19923817 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 303
Score = 63.9 bits (154), Expect = 2e-10
Identities = 49/200 (24%), Positives = 89/200 (44%), Gaps = 2/200 (1%)
Query: 11 LQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKVY 70
LQ + +TG + GIG+A E L+ + V QA+V
Sbjct: 16 LQGQVAIVTGGATGIGKAIVKELLELGSNVVIASRKLERLKSAADELQANLPPTKQARVI 75
Query: 71 IGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNVVA 130
Q ++ E++ + + + F I+ L+NN G S ISS+ +++TN+
Sbjct: 76 PIQCNIRNEEEVNNLVKSTLDTFGKINFLVNNGGGQFLSP-AEHISSKGWHAVLETNLTG 134
Query: 131 LINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKELINTG 190
+ +AV + ++ G IVN+ V + +P A++ V T+SL E +G
Sbjct: 135 TFYMCKAVYSSWMKEHGGSIVNI-IVPTKAGFPLAVHSGAARAGVYNLTKSLALEWACSG 193
Query: 191 IRVIEIAPGNVETEFSLVRY 210
IR+ +APG + ++ ++ Y
Sbjct: 194 IRINCVAPGVIYSQTAVENY 213
>CE26900 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 305
Score = 63.9 bits (154), Expect = 2e-10
Identities = 67/258 (25%), Positives = 106/258 (40%), Gaps = 17/258 (6%)
Query: 11 LQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKVY 70
L K + ITGA G+G+ A ++ AA G Q + +
Sbjct: 38 LYRKKVLITGAGNGLGKLLAQKF--AARGATLILWDINLQSVDELKNEIRGN---QGEAH 92
Query: 71 IGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNVVA 130
++++ + KI + + +DIL+NNAG A ++ + S +I D NV A
Sbjct: 93 SYEVNLCDPGKIAQVGQQVINDIGKVDILVNNAGIATAKMILDS-SENEINRSFDVNVKA 151
Query: 131 LINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKELINT- 189
Q LP N+G IV + S AG+ + Y ++KHA F SL E++ +
Sbjct: 152 HFYTVQQFLPAMLKDNNGHIVTIASAAGKMGSSGLADYSSTKHAAVGFHDSLVAEIMESE 211
Query: 190 --GIRVIEIAPGNVETEFSLVRYKGDADRAKQVYKGTTPLYADDIADLIVYATSRKPNTV 247
G++ + P V T S+ G A R ++ L D + I A + +
Sbjct: 212 KNGVKTTLVCPYYVHT--SMFDATGAATRFPWIF---PILDTDYVVQKIFEAIETEQEFL 266
Query: 248 I---ADVLVFASNQASPY 262
+ A LVFA Q PY
Sbjct: 267 VTPRAFYLVFAGIQILPY 284
>CE09641 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 314
Score = 63.9 bits (154), Expect = 2e-10
Identities = 62/192 (32%), Positives = 83/192 (42%), Gaps = 15/192 (7%)
Query: 18 ITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKVYIGQLDVT 77
+TGA+ GIG++ AL D A Y +V D T
Sbjct: 58 VTGATDGIGRSYAL---DLARRGFNIFLISRTKSKLVKTKKQILNKYSDIEVRYAICDFT 114
Query: 78 ET--EKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDT--NV--VAL 131
E + + +L E DI ILINN G + V ++G IDT NV V +
Sbjct: 115 RVSYEDYKRLLHSLNEV--DIGILINNVGMCFDNPEV----LHRVEGGIDTLTNVINVNI 168
Query: 132 INVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKELINTGI 191
+ +T +LP A+ SG IVN+GS AG S+Y A+K + FT L+KE N GI
Sbjct: 169 LPLTAGILPQMMARKSGIIVNIGSAAGSIHMAKWSVYSATKKYIEWFTSILQKEYENEGI 228
Query: 192 RVIEIAPGNVET 203
I P V T
Sbjct: 229 ICQTITPLLVST 240
>At5g50770 [Q] KOG1205 Predicted dehydrogenase
Length = 342
Score = 63.9 bits (154), Expect = 2e-10
Identities = 60/199 (30%), Positives = 83/199 (41%), Gaps = 6/199 (3%)
Query: 8 AERLQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQA 67
+E + K + ITGA++GIG+A A EY G P+
Sbjct: 42 SENVAGKVVVITGAASGIGEALAYEY--GKRGAYLALVDIRGEPLFHVAALAELYGSPEV 99
Query: 68 KVYIGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTN 127
+ DV++ + + FI F +D L+ NAG A +D N
Sbjct: 100 LPLVA--DVSKLQDCERFIRATVLHFGRLDHLVTNAGVAPLYFFADIEDVSKASPAMDIN 157
Query: 128 VVALINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKELI 187
+ T P K K G IV + S G A P S YCASK AV AF ++LR E
Sbjct: 158 FWGSVYCTFFASPYLK-KFRGRIVVIASGCGYIASPRLSFYCASKAAVIAFYETLRTE-F 215
Query: 188 NTGIRVIEIAPGNVETEFS 206
+ I V +APG V++E S
Sbjct: 216 GSDIGVTIVAPGIVDSEMS 234
>At2g29150 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 268
Score = 63.9 bits (154), Expect = 2e-10
Identities = 59/238 (24%), Positives = 107/238 (44%), Gaps = 14/238 (5%)
Query: 6 KAAERLQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYP 65
K+ L+ T +TG S G+G+A +E L V
Sbjct: 11 KSRWSLEGMTALVTGGSKGLGEAV-VEELAMLGARVHTCARDETQLQERLREWQAKGF-- 67
Query: 66 QAKVYIGQLDVTETEKIQPFIDNLPEEFKD-IDILINNAGKALGSDVVGTISSEDIKGMI 124
+V DV+ E+ + ++ + F+ ++IL+NNAG + ++ED ++
Sbjct: 68 --EVTTSVCDVSSREQREKLMETVSSVFQGKLNILVNNAGTGIIKPST-EYTAEDYSFLM 124
Query: 125 DTNVVALINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRK 184
TN+ + +++Q P+ KA SG IV + SVAG + SIY ASK A+ +SL
Sbjct: 125 ATNLESAFHLSQIAHPLLKASGSGSIVFMSSVAGL-VHTGASIYGASKGAMNQLGRSLAC 183
Query: 185 ELINTGIRVIEIAPGNVETEFSLVRYKGDADRAKQVYKGTTPL----YADDIADLIVY 238
E + IRV + P + T L + ++ ++ + TP+ A++++ L+ +
Sbjct: 184 EWASDNIRVNSVCPWVITT--PLTSFIFSDEKLRKAVEDKTPMGRVGEANEVSSLVAF 239
>7301828 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 335
Score = 63.9 bits (154), Expect = 2e-10
Identities = 54/224 (24%), Positives = 102/224 (45%), Gaps = 8/224 (3%)
Query: 4 GRKAAERLQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXX 63
GR+ + + ITG +G+G + A+ ++ + V
Sbjct: 17 GRQQLKVDSRHVVLITGCDSGLGHSMAVYCHESLHMTVISCCHNIKSEGAKLLQGLASAK 76
Query: 64 YPQAKVYIGQLDVTETEKIQPFIDNLPEEF-KD----IDILINNAGKALGSDVVGTISSE 118
++++ +LD+ E + I+ L + KD + LINNAG + ++ E
Sbjct: 77 DGLSRMHTLELDLLEPDSIRLVHRQLRDILAKDPSYRLTALINNAGVMCFGEFEWQLT-E 135
Query: 119 DIKGMIDTNVVALINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAF 178
I+ I+ N++ + +T +LP+ + + G I+N+ S G A P Y ASK A+R +
Sbjct: 136 QIEAQINCNLLGTMRLTHELLPLLR-QQQGRIINVTSHCGLQALPALGPYAASKAALRFW 194
Query: 179 TQSLRKELINTGIRVIEIAPGNVETEFSL-VRYKGDADRAKQVY 221
T SLR EL G+ V+ PG+ + ++ R + A + ++ +
Sbjct: 195 TDSLRVELQQYGMEVVNFIPGSFVLDSNIAARQQQHAQKMREAF 238
>7295622 [Q] KOG1205 Predicted dehydrogenase
Length = 247
Score = 63.9 bits (154), Expect = 2e-10
Identities = 63/256 (24%), Positives = 109/256 (41%), Gaps = 28/256 (10%)
Query: 9 ERLQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAK 68
ER ++ +TGAS+GIG A A + A V Q +
Sbjct: 2 ERWHDRVAVVTGASSGIGAAVARHLVSAGVIVVGLARRVDRMKAIKEQLPPEL----QGR 57
Query: 69 VYIGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNV 128
++ DV + + + D + E+ DIL+NNAG L + T+ E ++ +++ N+
Sbjct: 58 LHAIHCDVEDLDSVTAAFDWIEEQLGGCDILVNNAG-CLNPGQLLTLELEQLQQVLNVNL 116
Query: 129 VALINVTQAVLPIFKAKN-SGDIVNLGSVAGRDAY-PTG------SIYCASKHAVRAFTQ 180
+ ++ T+ + + G ++ + S+ GR+ P G ++Y +KH V A +
Sbjct: 117 MGVVICTRRAFRSMQQREVDGHVILINSLTGRNIINPPGDELQVLNMYPLTKHGVTAMLE 176
Query: 181 SLRKEL--INTGIRVIEIAPGNVETEFSLVRYKGDADRAKQVYKGTTP-LYADDIADLIV 237
LR+EL T I+V I PG +TE Y G P L DDIA I+
Sbjct: 177 VLRQELRGFKTKIKVTSITPGVTDTEILPSGY------------GILPMLKPDDIAAGIM 224
Query: 238 YATSRKPNTVIADVLV 253
Y + + ++ +
Sbjct: 225 YVLGTPAHVQVHELTI 240
>At1g63380 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 287
Score = 63.5 bits (153), Expect = 3e-10
Identities = 61/228 (26%), Positives = 98/228 (42%), Gaps = 8/228 (3%)
Query: 11 LQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKVY 70
L++K + +TGAS+GIG+ L+ A V QA
Sbjct: 22 LKDKVVLVTGASSGIGREICLDLCKAGCKIVAAARRVDRLNSLCSEINSFGAIGVQAVAL 81
Query: 71 IGQLDV-TETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNVV 129
+LDV +E + I+ + E F ID+LINNAG +S E+ + TN+
Sbjct: 82 --ELDVSSEADTIRKAVKEAWETFGKIDVLINNAGIRGNVKSSLDLSEEEWDKVFRTNLT 139
Query: 130 ALINVTQAVLPIFK-AKNSGDIVNLGSVAG--RDAYPTGSIYCASKHAVRAFTQSLRKEL 186
+++ V + + A+ G ++N+ S++G R G Y SK V T+ + EL
Sbjct: 140 GSWLISKYVCLLMRDAERGGSVINVSSISGLHRGLLRGGLAYACSKGGVDTMTRMMAIEL 199
Query: 187 INTGIRVIEIAPGNVETEFSLVRYKGDADRAKQVYKGTTPLYADDIAD 234
IRV IAPG +E + ++ + K+V + PL D
Sbjct: 200 AVYKIRVNSIAPGIFRSEITQGLFQ--KEWLKKVTEKVVPLKMQQTVD 245
>At1g62610 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 307
Score = 63.2 bits (152), Expect = 4e-10
Identities = 56/200 (28%), Positives = 88/200 (44%), Gaps = 6/200 (3%)
Query: 11 LQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKVY 70
L++K + +TGAS+GIG+ L+ A V QA
Sbjct: 44 LKDKVVLVTGASSGIGREICLDLCKAGCKIVAAARRVDRLNSLCSEINSFGAIGVQAAAL 103
Query: 71 IGQLDV-TETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNVV 129
+LDV ++ + I+ + E F ID+LINNAG +S E+ + TN+
Sbjct: 104 --ELDVSSDADTIRKAVKEAWEIFGTIDVLINNAGIRGNVKSSLDLSKEEWDKVFRTNLT 161
Query: 130 ALINVTQAVLPIFK-AKNSGDIVNLGSVAG--RDAYPTGSIYCASKHAVRAFTQSLRKEL 186
+++ V + + AK G ++N+ S++G R G Y SK V T+ + EL
Sbjct: 162 GSWLISKYVCLLMRDAKRGGSVINVSSISGLHRGLLRGGLAYACSKGGVDTMTRMMAIEL 221
Query: 187 INTGIRVIEIAPGNVETEFS 206
IRV IAPG +E +
Sbjct: 222 AVYKIRVNSIAPGIFRSEIT 241
>7297516 [IR] KOG4169 15-hydroxyprostaglandin dehydrogenase and related
dehydrogenases
Length = 256
Score = 63.2 bits (152), Expect = 4e-10
Identities = 39/142 (27%), Positives = 73/142 (50%), Gaps = 8/142 (5%)
Query: 65 PQAKVYIGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMI 124
P KV Q+++ E I+ + + + ID++IN G L DV T+ ++ GMI
Sbjct: 54 PSVKVVFMQMNLMEKMSIEQAMKKMGQMMGHIDVMINGEGVLLDKDVETTMGM-NLTGMI 112
Query: 125 DTNVVALINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRK 184
+ ++A+ + + + + G +VN+ SV G + P S+Y A+ H + FT+S+
Sbjct: 113 QSTMMAMPYMDKTQMGM-----GGMVVNMSSVYGLEPAPAFSVYAAAMHGILGFTRSMGD 167
Query: 185 ELI--NTGIRVIEIAPGNVETE 204
++I TG+ + + PG +E
Sbjct: 168 KMIYQKTGVMFMAMCPGLTNSE 189
>Hs7705907 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 270
Score = 62.8 bits (151), Expect = 5e-10
Identities = 35/129 (27%), Positives = 67/129 (51%), Gaps = 1/129 (0%)
Query: 75 DVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNVVALINV 134
DVT+ + ++ + F +D ++NNAG S++ + +++ N++ +
Sbjct: 62 DVTQEDDVKTLVSETIRRFGRLDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYTL 121
Query: 135 TQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKELINTGIRVI 194
T+ LP + K+ G+++N+ S+ G Y A+K AV A T++L + G+RV
Sbjct: 122 TKLALPYLR-KSQGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVN 180
Query: 195 EIAPGNVET 203
I+PGN+ T
Sbjct: 181 CISPGNIWT 189
>CE09969 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 257
Score = 62.8 bits (151), Expect = 5e-10
Identities = 40/169 (23%), Positives = 80/169 (46%), Gaps = 2/169 (1%)
Query: 86 IDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNVVALINVTQAVLPIFKAK 145
ID + F +DIL++NA + ++ ++D NV + +T+ +P +A
Sbjct: 79 IDFTLDRFTKLDILVSNAAVNPHYGDLMKVTDSQWDKLLDLNVKSAFELTKEAVPHLEAS 138
Query: 146 NSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKELINTGIRVIEIAPGNVETEF 205
G++V + SVAG Y K + ++SL L IRV IAPG ++T+F
Sbjct: 139 GRGNVVFVSSVAGYSPMNEIGAYSVMKTTLTGLSKSLALNLARRNIRVNSIAPGIIQTDF 198
Query: 206 SLVRYKGDADRAKQVYKGTTPLYA--DDIADLIVYATSRKPNTVIADVL 252
S V + ++++ K + + + D+ A+ + + S + + + + +
Sbjct: 199 SQVLFSDESEKQKWLSQIAQRRFGDPDECAEAVAFLVSDEASYISGETI 247
>CE07539 [Q] KOG1205 Predicted dehydrogenase
Length = 537
Score = 62.8 bits (151), Expect = 5e-10
Identities = 54/195 (27%), Positives = 87/195 (43%), Gaps = 12/195 (6%)
Query: 11 LQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKVY 70
++NK + ITGAS+G+G++ A E L V + K
Sbjct: 76 VKNKIVVITGASSGLGKSLAFE-LYKRGAQVILLARSTEKLKEICAELTKTFPLNKNKPT 134
Query: 71 IGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNVVA 130
D+T +K P+ + +D+LINNAG + T + K M +TN+
Sbjct: 135 YYFFDITNPDKA-PWA-----QIPKVDVLINNAGMSNRGSCQDTTMAIHRKAM-ETNLFG 187
Query: 131 LINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKELINTG 190
+ VTQ++L K G IV S+ G+ A P Y ASKHA++ + LR E +
Sbjct: 188 HVQVTQSLLS--KLSPDGCIVVTSSIQGKVAIPYRGSYSASKHALQGYFDCLRAE--HKN 243
Query: 191 IRVIEIAPGNVETEF 205
+ ++ ++ G + T F
Sbjct: 244 LHILVVSAGYINTGF 258
>7294126 [IR] KOG4169 15-hydroxyprostaglandin dehydrogenase and related
dehydrogenases
Length = 278
Score = 62.8 bits (151), Expect = 5e-10
Identities = 48/198 (24%), Positives = 84/198 (42%), Gaps = 18/198 (9%)
Query: 12 QNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKVYI 71
+ K +TG + GIG + + L A V +P V I
Sbjct: 21 RGKNAVVTGGAGGIGLQVSKQLLAAGAAKVAIIDLQDNLEEFVKLRAA----HPTQSVMI 76
Query: 72 GQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNVVAL 131
++DV + ++ + + + F +IDI++N V G + +D++ + N+ +
Sbjct: 77 IKMDVANKKGVEATYEEIAKTFGNIDIVVN---------VAGIFNDKDVQRTLLVNLGGI 127
Query: 132 INVTQAVLPIFKAKNSGD---IVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKELI- 187
IN T + LP N G +VN+ SV G D +Y A+K + FT+ L E
Sbjct: 128 INSTLSALPYMGKDNGGKGGIVVNMSSVVGLDPMFIIPVYGATKAGIINFTRCLANEKYY 187
Query: 188 -NTGIRVIEIAPGNVETE 204
+GI+ + + PG T+
Sbjct: 188 QRSGIKFVTVCPGATMTD 205
>CE26060 [Q] KOG1210 Predicted 3-ketosphinganine reductase
Length = 347
Score = 62.4 bits (150), Expect = 6e-10
Identities = 46/168 (27%), Positives = 82/168 (48%), Gaps = 2/168 (1%)
Query: 68 KVYIGQLDVTET-EKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDT 126
KV+ +D+T + I+ D+ E IDILINNAG ++ + + D + +
Sbjct: 94 KVHWKSIDMTGGYDVIKSAFDDAARELGPIDILINNAGHSVQAPFC-ELPITDFEKQMAV 152
Query: 127 NVVALINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKEL 186
N ++ ++ T+AV+ K + +G I + S AG+ A S Y +K A+R F +L EL
Sbjct: 153 NYLSAVHATRAVVDDMKTRKTGHISFVSSAAGQFAIFGYSAYSPTKFALRGFADTLHMEL 212
Query: 187 INTGIRVIEIAPGNVETEFSLVRYKGDADRAKQVYKGTTPLYADDIAD 234
+ + V + P N +TE V + + K++ + D+A+
Sbjct: 213 LPYKVNVGVLYPPNTDTEGFKVELETMPEETKKMSEAAGLFTPKDVAE 260
>At5g06060 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 264
Score = 62.4 bits (150), Expect = 6e-10
Identities = 60/218 (27%), Positives = 92/218 (41%), Gaps = 9/218 (4%)
Query: 11 LQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKVY 70
L KT +TG + GIG+A +E L V V
Sbjct: 9 LAGKTALVTGGTRGIGRAV-VEELAKFGAKVHTCSRNQEELNACLNDWKANGLVVSGSV- 66
Query: 71 IGQLDVTETEKIQPFIDNLPEEFKD-IDILINNAGKALGSDVVGTISSEDIKGMIDTNVV 129
D + ++ + I F ++ILINN G + V SSE+ ++ TN+
Sbjct: 67 ---CDASVRDQREKLIQEASSAFSGKLNILINNVGTNVRKPTV-EYSSEEYAKIMSTNLE 122
Query: 130 ALINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKELINT 189
+ +++Q P+ KA G IV + SVAG +GSIY A+K A+ T++L E +
Sbjct: 123 SAFHLSQIAHPLLKASGVGSIVFISSVAGLVHLSSGSIYGATKGALNQLTRNLACEWASD 182
Query: 190 GIRVIEIAPGNVETEFSLVRYKGDADRAKQVYKGTTPL 227
IR +AP ++T SLV + + TPL
Sbjct: 183 NIRTNCVAPWYIKT--SLVETLLEKKEFVEAVVSRTPL 218
>At3g06060 [Q] KOG1210 Predicted 3-ketosphinganine reductase
Length = 327
Score = 62.4 bits (150), Expect = 6e-10
Identities = 56/196 (28%), Positives = 86/196 (43%), Gaps = 12/196 (6%)
Query: 11 LQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKVY 70
++++ FITG S+GIG AL + A+ G + +
Sbjct: 37 IKSRHAFITGGSSGIG--LALAHRAASEGARVSILARSGSKLEEAKKSIQLATGVEVATF 94
Query: 71 IGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNVVA 130
DV + + + ID E ID+LI N G ++V S ED+K ID N+V
Sbjct: 95 --SADVRDYDAVSKAID----ESGPIDVLIVNQGVFTAKELVKH-SPEDVKFTIDVNLVG 147
Query: 131 LINVTQAVLPIFKAKNS---GDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKELI 187
NV +A LP KA+ I + S AG+ + Y ASK ++ Q+L++E+I
Sbjct: 148 SFNVIKAALPAMKARKDRGPASISLVSSQAGQVGVYGYAAYSASKFGLQGLAQALQQEVI 207
Query: 188 NTGIRVIEIAPGNVET 203
+ I V I P + T
Sbjct: 208 SDDIHVTLIFPPDTNT 223
>At3g46170 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 288
Score = 61.6 bits (148), Expect = 1e-09
Identities = 63/227 (27%), Positives = 95/227 (41%), Gaps = 7/227 (3%)
Query: 11 LQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKVY 70
L++K + +TGAS+GIG+ L+ A + QA
Sbjct: 26 LKDKVVLVTGASSGIGREICLDLGKAGCKIIAVARRVDRLNSLCSEINSSSSTGIQAAAL 85
Query: 71 IGQLDVT-ETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNVV 129
+LDVT + IQ + F ID LINNAG +S E+ + TN+
Sbjct: 86 --KLDVTSDAATIQKVVQGAWGIFGKIDALINNAGIRGNVKSSLDLSKEEWDNVFKTNLT 143
Query: 130 ALINVTQAVLPIFK-AKNSGDIVNLGSVAG-RDAYPTGSIYCASKHAVRAFTQSLRKELI 187
V++ V + + AK G ++N+ S+AG R P Y SK V ++ + EL
Sbjct: 144 GPWLVSKYVCVLMRDAKLGGSVINISSIAGIRGILPGALAYACSKIGVDTMSKMMAVELG 203
Query: 188 NTGIRVIEIAPGNVETEFSLVRYKGDADRAKQVYKGTTPLYADDIAD 234
IRV IAPG ++E + + + K V + T PL D
Sbjct: 204 VHKIRVNSIAPGIFKSE--ITQGLMQKEWFKNVTERTVPLKLQQTVD 248
>Hs14754051 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 245
Score = 61.2 bits (147), Expect = 1e-09
Identities = 62/243 (25%), Positives = 105/243 (42%), Gaps = 30/243 (12%)
Query: 10 RLQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKV 69
+L K I +T A+ GIGQA AL ++ + +
Sbjct: 3 QLDGKVIILTAAAQGIGQAAALAFVREG--------------AKVIATDINVSKLQELEK 48
Query: 70 YIG----QLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMID 125
Y+G LDVT+ ++I F + E + +D+L N AG V+ +D ++
Sbjct: 49 YLGIQTRVLDVTKKKQIDQFAN----EVERLDVLFNVAGFVHHGTVLDC-EEKDWDFSMN 103
Query: 126 TNVVALINVTQAVLPIFKAKNSGDIVNLGSVAGR-DAYPTGSIYCASKHAVRAFTQSLRK 184
NV + + +A LP A+ SG+I+ + SV +Y +K AV T+S+
Sbjct: 104 LNVRSTYLMIKAFLPKMLAQKSGNIITMFSVVSSIKGVVNRCVYSTTKAAVIGLTKSVAA 163
Query: 185 ELINTGIRVIEIAPGNVETEF--SLVRYKGDADRAKQVYKGTTPL----YADDIADLIVY 238
+ I GIR + PG V+T ++ +G+ + A+ + + A++IA L VY
Sbjct: 164 DFIQQGIRCNCVCPGTVDTPSLQERIQARGNPEEARNDFLKRQKMGRFATAEEIAMLCVY 223
Query: 239 ATS 241
S
Sbjct: 224 VAS 226
>CE09504 [R] KOG1611 Predicted short chain-type dehydrogenase
Length = 249
Score = 61.2 bits (147), Expect = 1e-09
Identities = 60/237 (25%), Positives = 99/237 (41%), Gaps = 27/237 (11%)
Query: 14 KTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKVYIGQ 73
K+I ITGA+ GIG +++ + + +V+I Q
Sbjct: 4 KSILITGANRGIGLGLLKQFIKNKDVQIIIGTCRDPSNATELNSIK------DTRVHILQ 57
Query: 74 LDVTETEKIQPF---IDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNVVA 130
LD+ + I+ ++ L E + +LINNAG + D+ G S + ++TN ++
Sbjct: 58 LDIDCDDSIRKLGAEVEKLVGE-DGLTVLINNAGIFVPYDIDGEKSRSTLIRQLETNTIS 116
Query: 131 LINVTQAVLPIFK---AKNSGD--------IVNLGSVAGRDAYPTGS------IYCASKH 173
+ +TQ +LP+ K AKN G+ I+N+ S AG S Y SK
Sbjct: 117 TVLITQELLPLLKRAAAKNRGEGYSINRSAIINISSTAGSITKIDASYNIPLVAYRMSKS 176
Query: 174 AVRAFTQSLRKELINTGIRVIEIAPGNVETEFSLVRYKGDADRAKQVYKGTTPLYAD 230
A+ +F +S +L I V PG V+T+ K + D A + + D
Sbjct: 177 ALNSFGKSCSVDLAKYHILVTTFCPGWVKTDMGGANGKLEIDDATKTLSDNILILGD 233
>At2g29310 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 262
Score = 61.2 bits (147), Expect = 1e-09
Identities = 61/232 (26%), Positives = 96/232 (41%), Gaps = 11/232 (4%)
Query: 11 LQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKVY 70
LQ T +TGA++GIG A E A+ G + + +
Sbjct: 7 LQGMTALVTGAASGIGYAIVEEL--ASFGAIIHICDISETLLSQSLSEWEKKGFQVSGSI 64
Query: 71 IGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNVVA 130
+ EK+ + +L + ++IL+NN G G ++ ED I TN+
Sbjct: 65 CDVASRPDREKLMQTVSSLFDG--KLNILVNNVGVIRGKPTTEYVA-EDFSYHISTNLEP 121
Query: 131 LINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKELINTG 190
+ +Q + KA G IV + S G + GSIY +K A+ T++L E G
Sbjct: 122 AFHFSQLSHLLLKASGFGSIVFMSSATGVVSVQCGSIYSLTKGALNQLTRNLACEWAKDG 181
Query: 191 IRVIEIAPGNVETEFSLVRYKGDADRAKQVYKGTTPL----YADDIADLIVY 238
IR +AP V+T S Y D K+ TPL +++A L+V+
Sbjct: 182 IRANAVAPNVVKTPLS-QSYLEDVG-FKEALFSRTPLGRAGEPNEVASLVVF 231
>At5g04900 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 341
Score = 60.8 bits (146), Expect = 2e-09
Identities = 57/196 (29%), Positives = 89/196 (45%), Gaps = 12/196 (6%)
Query: 16 IFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKVYIGQLD 75
I ITG++ GIG A A E+L A + V + V+ + D
Sbjct: 82 ILITGSTKGIGYALAREFLKAGDNVVICSRSAERVETAVQSLKEEFGEH----VWGTKCD 137
Query: 76 VTETEKIQPFIDNLPEEFKDIDILINNAG-KALGSDVVGTISSEDIKGMIDTNVVAL-IN 133
VTE + ++ + + K IDI INNAG A + S ED+ ++ TN + L +
Sbjct: 138 VTEGKDVRELVAYSQKNLKYIDIWINNAGSNAYSFKPLAEASDEDLIEVVKTNTLGLMLC 197
Query: 134 VTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTG--SIYCASKHAVRAFTQSLRKELINTGI 191
+A+ + G I N+ AG D PT + Y A+K +V T+SL+ EL +
Sbjct: 198 CREAMNMMLTQSRGGHIFNIDG-AGSDGRPTPRFAAYGATKRSVVHLTKSLQAELQMQDV 256
Query: 192 R---VIEIAPGNVETE 204
+ V ++PG V T+
Sbjct: 257 KNVVVHNLSPGMVTTD 272
>7304176 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 280
Score = 60.8 bits (146), Expect = 2e-09
Identities = 50/193 (25%), Positives = 82/193 (41%), Gaps = 15/193 (7%)
Query: 14 KTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKVYIGQ 73
K +TGA+ GIG+ TALE A G Q ++ +
Sbjct: 15 KVFIVTGANTGIGKETALEI--ARRGGTVYLACRDMNRCEKARKDIIKETNNQ-NIFSRE 71
Query: 74 LDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNVVALIN 133
LD++ + I+ F+D +E + +LINNAG T++ + + + N +
Sbjct: 72 LDLSSLDSIRKFVDGFKKEQPKLHVLINNAGVMRCPK---TLTKDGYELQLGVNHIGHFL 128
Query: 134 VTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKELINTGIRV 193
+T +L + KA + + +Y G Y SK A FT+ L K L +G+ V
Sbjct: 129 LTNLLLDVLKATD---------LNSEKSYDEGLAYSQSKLANVLFTRELAKRLEGSGVTV 179
Query: 194 IEIAPGNVETEFS 206
+ PG V+TE +
Sbjct: 180 NALHPGVVDTELA 192
>CE19894 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 260
Score = 60.1 bits (144), Expect = 3e-09
Identities = 59/252 (23%), Positives = 101/252 (39%), Gaps = 11/252 (4%)
Query: 10 RLQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKV 69
R + K +T A+ GIG A A LD G +
Sbjct: 7 RFEGKVAIVTAATKGIGLAIAERLLD--EGASVVIGSRNQKNVDEAIEYLKNKGLTKVAG 64
Query: 70 YIGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNVV 129
G + T+ +K +D ++F I+IL+NN G + +S + + + NV
Sbjct: 65 IAGHIASTDDQK--KLVDFTLQKFGKINILVNNHGINPAFGHILEVSDQVWDKLFEVNVK 122
Query: 130 ALINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKELINT 189
A +T+ V P + G I+ S + + P + Y +K + T++L L
Sbjct: 123 AGFQMTKLVHPHIAKEGGGAIIFNASYSAYKSPPGIAAYGVTKTTLVGLTRALAMGLAKD 182
Query: 190 GIRVIEIAPGNVETEFSLVRYKGDADRAK------QVYKGTTPLYADDIADLIVYATSRK 243
IRV IAPG ++T+ S V + G D K ++ G + DD A + Y S
Sbjct: 183 NIRVNGIAPGVIKTKMSQVLWDGGEDAEKELTDIQEIALGRLGV-PDDCAGTVAYLASDD 241
Query: 244 PNTVIADVLVFA 255
+ + ++++ A
Sbjct: 242 SSYITGEMIIIA 253
>CE13054 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 240
Score = 60.1 bits (144), Expect = 3e-09
Identities = 43/139 (30%), Positives = 64/139 (45%), Gaps = 5/139 (3%)
Query: 67 AKVYIGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDT 126
AK Y +D++E ++I D + E +DIL+NNAG G ++ +K +
Sbjct: 23 AKAYT--VDLSEYKEINRTADLVKSEVGKVDILVNNAGIVTGKKLLQCPDELMVK-TVSV 79
Query: 127 NVVALINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKEL 186
N AL T+ LP N G IV + S+AG+ YCASKH F SL EL
Sbjct: 80 NTNALFFTTKNFLPGMLESNKGHIVTIASMAGKCGVAGLVDYCASKHGAVGFNDSLASEL 139
Query: 187 --INTGIRVIEIAPGNVET 203
+ ++ + P + T
Sbjct: 140 YALKKDVKTTVVCPIYINT 158
>7300947 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 361
Score = 60.1 bits (144), Expect = 3e-09
Identities = 45/176 (25%), Positives = 77/176 (43%), Gaps = 5/176 (2%)
Query: 11 LQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKVY 70
+ K +TG +G+G+ LE A G AK Y
Sbjct: 90 VSGKVALVTGGGSGLGREICLEL--ARRGCKLAVVDVNSKGCYETVELLSKIPRCVAKAY 147
Query: 71 IGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNVVA 130
+ DV+ ++Q + +E +DIL+NNA + ++ S++I ++ N+ +
Sbjct: 148 --KNDVSSPRELQLMAAKVEKELGPVDILVNNAS-LMPMTSTPSLKSDEIDTILQLNLGS 204
Query: 131 LINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKEL 186
I T+ LP + SG +V + ++AG P IY A+K+ + F +SLR EL
Sbjct: 205 YIMTTKEFLPKMINRKSGHLVAVNALAGLVPLPGAGIYTATKYGIEGFMESLRAEL 260
>7293420 [Q] KOG1199 Short-chain alcohol dehydrogenase/3-hydroxyacyl-CoA
dehydrogenase
Length = 255
Score = 60.1 bits (144), Expect = 3e-09
Identities = 54/204 (26%), Positives = 82/204 (39%), Gaps = 19/204 (9%)
Query: 11 LQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKVY 70
++N +TG ++G+G+ATA E L +V KV
Sbjct: 2 IKNAVSLVTGGASGLGRATA-ERLAKQGASVILADLPSSKGNEVAKELGD-------KVV 53
Query: 71 IGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISS-----EDIKGMID 125
+DVT + + + ++F +D+ +N AG A + ED + +I+
Sbjct: 54 FVPVDVTSEKDVSAALQTAKDKFGRLDLTVNCAGTATAVKTFNFNKNVAHRLEDFQRVIN 113
Query: 126 TNVVALINVTQAVLPIFKAKNS------GDIVNLGSVAGRDAYPTGSIYCASKHAVRAFT 179
N V NV + + A G IVN SVA D + Y ASK AV T
Sbjct: 114 INTVGTFNVIRLSAGLMGANEPNQDGQRGVIVNTASVAAFDGQIGQAAYSASKAAVVGMT 173
Query: 180 QSLRKELINTGIRVIEIAPGNVET 203
+ ++L GIR+ IAPG T
Sbjct: 174 LPIARDLSTQGIRICTIAPGLFNT 197
>At2g30670 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 262
Score = 59.7 bits (143), Expect = 4e-09
Identities = 52/215 (24%), Positives = 89/215 (41%), Gaps = 8/215 (3%)
Query: 11 LQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKVY 70
LQ T +TG ++GIG A +E L + +
Sbjct: 7 LQGMTALVTGGASGIGHAI-VEELAGLGARIYVCDISETLLNQSLSEWEKKGFQVSGSI- 64
Query: 71 IGQLDVTETEKIQPFIDNLPEEFKD-IDILINNAGKALGSDVVGTISSEDIKGMIDTNVV 129
DV+ + + + + + F ++IL+NN G + +++ D I TN+
Sbjct: 65 ---CDVSSHSERETLMQTVSKMFDGKLNILVNNVGVVNPKPTIEYVAA-DFSFSISTNLE 120
Query: 130 ALINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKELINT 189
+ +++Q P+ KA G I+ + SV G + GSIY +K A+ ++L E
Sbjct: 121 SAYHLSQLSHPLLKASEFGSIIFISSVGGVVSMECGSIYSLTKGALNQLAKTLACEWARD 180
Query: 190 GIRVIEIAPGNVETEFSLVRYKGDADRAKQVYKGT 224
GIR +AP + T + +K DAD K + T
Sbjct: 181 GIRANSVAPNFIYTAMAQPFFK-DADYEKSLVSRT 214
>7298742 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 399
Score = 59.7 bits (143), Expect = 4e-09
Identities = 43/128 (33%), Positives = 64/128 (49%), Gaps = 4/128 (3%)
Query: 74 LDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNVVALIN 133
+D+++ E++ D + +E DI +LINNAG G ++ T I+ + NV+A
Sbjct: 142 VDISKKEEVYKAADVIRDEVGDITLLINNAGVVSGLHLLDT-PDHLIERSFNVNVMAHFW 200
Query: 134 VTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKELI---NTG 190
T+A LP + G I + S+AG YCASK A F ++LR EL +T
Sbjct: 201 TTKAFLPKMIENDRGHIATIASLAGHVGISKLVDYCASKFAAVGFDEALRLELEVLGHTN 260
Query: 191 IRVIEIAP 198
IR I P
Sbjct: 261 IRTTCICP 268
>Hs4504503 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 387
Score = 59.3 bits (142), Expect = 5e-09
Identities = 55/215 (25%), Positives = 93/215 (42%), Gaps = 16/215 (7%)
Query: 11 LQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKVY 70
+ K + +TG G+G A +YLD V ++
Sbjct: 80 VDQKAVLVTGGDCGLGHALC-KYLDELGFTVFAGVLNENGPGAEELRRTCS-----PRLS 133
Query: 71 IGQLDVTETEKIQPFIDNLPEEFKDIDI--LINNAGKALGSDVVGTIS-SEDIKGMIDTN 127
+ Q+D+T+ +I+ + +D + +INNAG LG G + D K + N
Sbjct: 134 VLQMDITKPVQIKDAYSKVAAMLQDRGLWAVINNAG-VLGFPTDGELLLMTDYKQCMAVN 192
Query: 128 VVALINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKELI 187
+ VT+ LP+ + K+ G +VN+ S+ G + Y +SK AV F+ +R EL
Sbjct: 193 FFGTVEVTKTFLPLLR-KSKGRLVNVSSMGGGAPMERLASYGSSKAAVTMFSSVMRLELS 251
Query: 188 NTGIRVIEIAPGNVETEFSLVRYKGDADRAKQVYK 222
GI+V I PG T + G +D+ +++ K
Sbjct: 252 KWGIKVASIQPGGFLTNIA-----GTSDKWEKLEK 281
>Hs14249446 [I] KOG1200 Mitochondrial/plastidial beta-ketoacyl-ACP reductase
Length = 179
Score = 59.3 bits (142), Expect = 5e-09
Identities = 36/125 (28%), Positives = 63/125 (49%), Gaps = 1/125 (0%)
Query: 75 DVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNVVALINV 134
DV + +Q + + + ++ L+N AG +V T +ED+ + TN++ +
Sbjct: 56 DVAKEHDVQNTFEEMEKHLGRVNFLVNAAGINRDGLLVRT-KTEDMVSQLHTNLLGSMLT 114
Query: 135 TQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKELINTGIRVI 194
+A + + G IVN+GS+ G S+Y ASK + F+++L KE+ IRV
Sbjct: 115 CKAAMRTMIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEVARKKIRVN 174
Query: 195 EIAPG 199
+APG
Sbjct: 175 VVAPG 179
>CE02786 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 305
Score = 59.3 bits (142), Expect = 5e-09
Identities = 39/137 (28%), Positives = 66/137 (47%), Gaps = 3/137 (2%)
Query: 72 GQLDVTETEKIQPFIDNLPEEFKDIDI--LINNAGKALGSDVVGTISSEDIKGMIDTNVV 129
G L+V E ++ F+ + + ++ + ++ NAG S +S++D + N
Sbjct: 63 GILNVANDESVKEFVKLVEKTVENRGLWGVVANAGILGNSGPDDWLSAQDYINTMQVNTF 122
Query: 130 ALINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKELINT 189
++ Q L F K G +V + S++GR PT YC SKHAV A+ +R ELI+
Sbjct: 123 GVMRFIQG-LKKFVKKQEGRVVIISSISGRTPRPTVGPYCVSKHAVEAYADVIRHELIDF 181
Query: 190 GIRVIEIAPGNVETEFS 206
+ V + PG T +
Sbjct: 182 NVSVHLLEPGFFTTNIT 198
>7304181 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 331
Score = 59.3 bits (142), Expect = 5e-09
Identities = 55/211 (26%), Positives = 86/211 (40%), Gaps = 20/211 (9%)
Query: 14 KTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKVYIGQ 73
K +TGA+ GIG+ T E + G V VY Q
Sbjct: 46 KVFIVTGANTGIGKETVRE-IAKRGGTVYMACRNLKKCEEAREEIVLETK--NKYVYCRQ 102
Query: 74 LDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNVVALIN 133
D+ E I+ F+ E + + +LINNAG +++S+ I+ + N +
Sbjct: 103 CDLASQESIRHFVAAFKREQEHLHVLINNAGVMR---CPRSLTSDGIELQLGVNHMGHFL 159
Query: 134 VTQAVLPIFKAKNSGDIVNLGSVA------------GRDAYPTGSIYCASKHAVRAFTQS 181
+T +L + K + IVN+ S+A +Y G Y SK A FT+
Sbjct: 160 LTNLLLDLLKKSSPSRIVNVSSLAHTRGEINTGDLNSDKSYDEGKAYSQSKLANVLFTRE 219
Query: 182 LRKELINTGIRVIEIAPGNVETEFSLVRYKG 212
L K L T + + PG V+TE ++R+ G
Sbjct: 220 LAKRLEGTNVTANALHPGVVDTE--IIRHMG 248
>Hs10337605 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 260
Score = 58.9 bits (141), Expect = 7e-09
Identities = 60/261 (22%), Positives = 104/261 (38%), Gaps = 7/261 (2%)
Query: 2 SQGRKAAERLQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXX 61
S G + L NK +T ++ GIG A A V
Sbjct: 3 SSGMTRRDPLANKVALVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNVDQAVATLQGEG 62
Query: 62 XXYPQAKVYIGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIK 121
++G+ + + E++ L IDIL++NA + ++ E
Sbjct: 63 LSVTGTVCHVGKAE--DRERLVAMAVKL---HGGIDILVSNAAVNPFFGSLMDVTEEVWD 117
Query: 122 GMIDTNVVALINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQS 181
+D NV A +T+AV+P + + G +V + S+A P S Y SK A+ T++
Sbjct: 118 KTLDINVKAPALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLTKT 177
Query: 182 LRKELINTGIRVIEIAPGNVETEFSLVRY--KGDADRAKQVYKGTTPLYADDIADLIVYA 239
L EL IRV +APG ++T FS + + K + K+ + +D A ++ +
Sbjct: 178 LAIELAPRNIRVNCLAPGLIKTSFSRMLWMDKEKEESMKETLRIRRLGEPEDCAGIVSFL 237
Query: 240 TSRKPNTVIADVLVFASNQAS 260
S + + + +V S
Sbjct: 238 CSEDASYITGETVVVGGGTPS 258
>7298167 [IR] KOG4169 15-hydroxyprostaglandin dehydrogenase and related
dehydrogenases
Length = 256
Score = 58.9 bits (141), Expect = 7e-09
Identities = 55/200 (27%), Positives = 77/200 (38%), Gaps = 23/200 (11%)
Query: 11 LQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKVY 70
L NK + GIG T+ E L N+ P+ V
Sbjct: 5 LTNKNVIFVAGLGGIGLDTSKELLKRDLKNLVILDRIENPAAIAELKAIN----PKVTVT 60
Query: 71 IGQLDVT----ETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDT 126
DVT ET K+ + + + K +D+LIN AG + I+ I
Sbjct: 61 FYPYDVTVPIAETTKL---LKTIFAQLKTVDVLINGAG---------ILDDHQIERTIAV 108
Query: 127 NVVALINVTQAVLPIFKAKNSGD---IVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLR 183
N L+N T A+L + + G I N+GSV G +A +Y +K AV FT SL
Sbjct: 109 NYTGLVNTTTAILDFWDKRKGGPGGIICNIGSVTGFNAIYQVPVYSGTKAAVVNFTSSLA 168
Query: 184 KELINTGIRVIEIAPGNVET 203
K TG+ + PG T
Sbjct: 169 KLAPITGVTAYTVNPGITRT 188
>CE08067 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 388
Score = 58.5 bits (140), Expect = 9e-09
Identities = 54/195 (27%), Positives = 85/195 (42%), Gaps = 7/195 (3%)
Query: 14 KTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKVYIGQ 73
K + ITG +G G+ A LD + NV P+ ++Y Q
Sbjct: 33 KYVMITGCDSGFGRLLATSLLDK-HVNVFAACFTQQGMASLHSEWKLKKG-PKGQLYTLQ 90
Query: 74 LDVTETEKI---QPFIDN-LPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNVV 129
LDVT + + F+ L E+ + L+NNAG S ++ ++ N +
Sbjct: 91 LDVTSQASVDSAKSFVTKILKEQNSKLWGLVNNAGIFSIHGPDDWCSVDEYASSLNVNTL 150
Query: 130 ALINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKELINT 189
+ + A +P+ K K+ G IV +GS AGR + Y +K AV A+ LR E+
Sbjct: 151 GAVRMCHAFVPLIK-KSRGRIVTMGSTAGRLHGLYVAPYVTAKFAVEAYMDCLRLEMRPF 209
Query: 190 GIRVIEIAPGNVETE 204
G+ V + PG +TE
Sbjct: 210 GVSVHILEPGCFKTE 224
>CE06423 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 307
Score = 58.5 bits (140), Expect = 9e-09
Identities = 49/196 (25%), Positives = 82/196 (41%), Gaps = 9/196 (4%)
Query: 11 LQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKVY 70
++ K + ITG+ +GIG+ ALE+ V +A +
Sbjct: 37 VEGKKVLITGSGSGIGRLMALEFAKLGAEVVIWDVNKDGAEETKNQVVKAGG---KASTF 93
Query: 71 IGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNVVA 130
+ +D+++ + I E DIDILINNAG G + E ++ + N A
Sbjct: 94 V--VDLSQYKDIHKVAKETKEAVGDIDILINNAGIVTGKKLF-DCPDELMEKTMAVNTNA 150
Query: 131 LINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKELI--- 187
L + LP K++G +V + S+AG+ YCASKH S+ E++
Sbjct: 151 LFYTAKNFLPSMLEKDNGHLVTIASMAGKTGCVGLVDYCASKHGAIGCHDSIAMEILAQK 210
Query: 188 NTGIRVIEIAPGNVET 203
G+ + P ++T
Sbjct: 211 KYGVNTTLVCPFFIDT 226
>CE01875 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 333
Score = 58.5 bits (140), Expect = 9e-09
Identities = 57/204 (27%), Positives = 82/204 (39%), Gaps = 24/204 (11%)
Query: 18 ITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKVYIGQLDVT 77
+TGA+ GIG+A A E A Y +V D T
Sbjct: 69 VTGATDGIGKAYAFEL---ARRGFNVLLVSRTQSKLDETKKEILEKYSSIEVRTAAFDFT 125
Query: 78 ETEKIQPFIDNLPEEFKD---------IDILINNAGKALG-SDVVGTISS--EDIKGMID 125
P +KD I +LINN G + DV+ + E + +
Sbjct: 126 NAA---------PSAYKDLLATLNQVEIGVLINNVGMSYEYPDVLHKVDGGIERLANITT 176
Query: 126 TNVVALINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKE 185
N + ++ +LP A+ +G IVN+GS AG + ++Y A+K V T LRKE
Sbjct: 177 INTLPPTLLSAGILPQMVARKAGVIVNVGSSAGANQMALWAVYSATKKYVSWLTAILRKE 236
Query: 186 LINTGIRVIEIAPGNVETEFSLVR 209
+ GI V IAP V T+ S V+
Sbjct: 237 YEHQGITVQTIAPMMVATKMSKVK 260
>At4g03140 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 283
Score = 58.5 bits (140), Expect = 9e-09
Identities = 64/245 (26%), Positives = 98/245 (39%), Gaps = 23/245 (9%)
Query: 10 RLQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKV 69
+L+ K ITG ++GIG+ATA +++ + +P
Sbjct: 17 KLEGKVALITGGASGIGKATAGKFISHGAKVIIADIQPQIGRETEQELGPSCAYFP---- 72
Query: 70 YIGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIK---GMIDT 126
DVT+ I +D +DI+ NNAG + +I D+ +I+T
Sbjct: 73 ----CDVTKESDIANAVDFAVSLHTKLDIMYNNAG--IPCKTPPSIVDLDLNVFDKVINT 126
Query: 127 NVVALINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKEL 186
NV ++ + + +NSG I+ GSV G Y SK AV +S EL
Sbjct: 127 NVRGVMAGIKHAARVMIPRNSGSIICAGSVTGMMGGLAQHTYSVSKSAVIGIVRSTASEL 186
Query: 187 INTGIRVIEIAPGNVETEFSLVR----YKG-DADRAKQVYKGTTPLYAD-----DIADLI 236
IRV I+P + T F + Y G D R Q+ + T L + D+A+
Sbjct: 187 CKHRIRVNCISPFAITTSFVMDEMRQIYPGVDDSRLIQIVQSTGVLNGEVCEPTDVANAA 246
Query: 237 VYATS 241
VY S
Sbjct: 247 VYLAS 251
>At2g29350 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 269
Score = 58.5 bits (140), Expect = 9e-09
Identities = 57/240 (23%), Positives = 103/240 (42%), Gaps = 14/240 (5%)
Query: 4 GRKAAERLQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXX 63
G + L T +TG S GIG+A +E L V
Sbjct: 8 GENSRWSLGGMTALVTGGSKGIGEAV-VEELAMLGAKVHTCARDETQLQERLREWQAKGF 66
Query: 64 YPQAKVYIGQLDVTETEKIQPFIDNLPEEFKD-IDILINNAGKALGSDVVGTISSEDIKG 122
V DV+ ++ ++ + ++ ++IL+NN G ++ ++ED
Sbjct: 67 QVTTSV----CDVSSRDQRVKLMETVSSLYQGKLNILVNNVGTSIFKPTT-EYTAEDFSF 121
Query: 123 MIDTNVVALINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSL 182
++ TN+ + +++Q P+ KA SG IV + S AG GSIY A+K A+ ++L
Sbjct: 122 VMATNLESAFHLSQLAHPLLKASGSGSIVLISSAAGVVHVNVGSIYGATKGAMNQLARNL 181
Query: 183 RKELINTGIRVIEIAPGNVETEFSLVRYKGDADRAKQVYKGTTPL----YADDIADLIVY 238
E + IR + P + T S + D + K+ + TTP+ A++++ L+ +
Sbjct: 182 ACEWASDNIRTNSVCPWYITTPLSNDFF--DEEFKKEAVR-TTPMGRVGEANEVSPLVAF 238
>7300387 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 317
Score = 58.5 bits (140), Expect = 9e-09
Identities = 49/206 (23%), Positives = 85/206 (40%), Gaps = 17/206 (8%)
Query: 10 RLQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKV 69
+++ KT+ ITGA++GIG+ TA D A K+
Sbjct: 30 KMEGKTVIITGANSGIGKETA---KDLAGRGARIIMACRNLETANAVKDEIVKETKNNKI 86
Query: 70 YIGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNVV 129
+ +LD+ + ++ F ++ + ID+LI+NAG AL G S + ++ + TN
Sbjct: 87 LVKKLDLGSQKSVREFAADIVKTEPKIDVLIHNAGMALA--FRGQTSEDGVELTMATNHY 144
Query: 130 ALINVTQAVLPIFKAKNSGDI------------VNLGSVAGRDAYPTGSIYCASKHAVRA 177
+T ++ + K I VNL + +P +Y SK A
Sbjct: 145 GPFLLTHLLIDVLKKSAPARIVIVASELYRLSSVNLAKLNPIGTFPAAYLYYVSKFANIY 204
Query: 178 FTQSLRKELINTGIRVIEIAPGNVET 203
F + L K L T + V + PG +++
Sbjct: 205 FARELAKRLEGTKVTVNFLHPGMIDS 230
>Hs20373187 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 231
Score = 58.2 bits (139), Expect = 1e-08
Identities = 51/196 (26%), Positives = 81/196 (41%), Gaps = 8/196 (4%)
Query: 6 KAAERLQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYP 65
K + + + + ITGA +G+G+ AL++ A G+V
Sbjct: 33 KPRKNVAGEIVLITGAGSGLGRLLALQF--ARLGSVLVLWDINKEGNEETCKMAREAGAT 90
Query: 66 QAKVYIGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMID 125
+ Y D ++ E + D + +E D+ ILINNAG G + E ++ D
Sbjct: 91 RVHAYT--CDCSQKEGVYRVADQVKKEVGDVSILINNAGIVTGKKFLDC-PDELMEKSFD 147
Query: 126 TNVVALINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKE 185
N A + +A LP A + G +V + S AG + YCASK A F +S+ E
Sbjct: 148 VNFKAHLWTYKAFLPAMIANDHGHLVCISSSAGLSGVNGLADYCASKFAAFGFAESVFVE 207
Query: 186 LI---NTGIRVIEIAP 198
GI+ + P
Sbjct: 208 TFVQKQKGIKTTIVCP 223
>CE13008 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 247
Score = 58.2 bits (139), Expect = 1e-08
Identities = 64/257 (24%), Positives = 104/257 (39%), Gaps = 32/257 (12%)
Query: 10 RLQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKV 69
R K++ +TG+S+GIG+ATA+ L A G V
Sbjct: 3 RFSGKSVIVTGSSSGIGRATAV--LFAKYGAQVTITGRDAGKLEATKKKMLKVMKNPENV 60
Query: 70 YIGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNVV 129
+ ++T+++ + + + F ID+L+NNAG + T S ++ +
Sbjct: 61 CVVVANLTDSDGQDEIVQSALDAFGRIDVLVNNAGANVVDGTFNTDQSTEL-----YHKT 115
Query: 130 ALINVTQAVLPIFKAKN-----SGDIVNLGSV-AGRDAYPTGSIYCASKHAVRAFTQSLR 183
IN + + K KN G+IVN+ SV AG A Y ASK A+ +T+ +
Sbjct: 116 FQINFEAVIEMVKKTKNHLIESKGEIVNVSSVAAGPQALAPSPYYAASKAALDQYTRCVA 175
Query: 184 KELINTGIRVIEIAPGNVETEFSLVRYKGDADRAKQVYKGTTPLYADDIADLIVYATSRK 243
+LI GI E F+ R A + +DIA+LI++ RK
Sbjct: 176 LDLILQGI----------EENFTSNRACIPAGVCGK---------PEDIAELIIFLADRK 216
Query: 244 PNTVIADVLVFASNQAS 260
++ I + A S
Sbjct: 217 RSSYIIGQSIVADGGTS 233
>7304178 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 296
Score = 58.2 bits (139), Expect = 1e-08
Identities = 52/203 (25%), Positives = 77/203 (37%), Gaps = 18/203 (8%)
Query: 14 KTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKVYIGQ 73
+ +TG + GIG+ T LE A ++ Q
Sbjct: 15 RVAIVTGCNQGIGKETVLEL---ARRGATVYMACRDMKKCENARREIIKATNNQNIFARQ 71
Query: 74 LDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNVVALIN 133
LD+ + I+ F E + ILINNAG D ++ + + I N +
Sbjct: 72 LDLCSMKSIRNFAAGFKREQNKLHILINNAGIM---DCPKMLTEDGFEMQIGVNHMGHFL 128
Query: 134 VTQAVLPIFKAKNSGDIVNLGSVAGR------------DAYPTGSIYCASKHAVRAFTQS 181
+T +L + K+ +V L S+A R +Y YC SK A FT+
Sbjct: 129 LTLLLLDVLKSSAPSRVVVLSSIAHRFGRIKRDDLNSEKSYDRKMAYCQSKLANVLFTRE 188
Query: 182 LRKELINTGIRVIEIAPGNVETE 204
L K L TG+ V + PG V TE
Sbjct: 189 LAKRLSGTGVTVNALHPGVVNTE 211
>YIR036c [Q] KOG1204 Predicted dehydrogenase
Length = 263
Score = 57.8 bits (138), Expect = 2e-08
Identities = 49/196 (25%), Positives = 85/196 (43%), Gaps = 10/196 (5%)
Query: 14 KTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKVYIGQ 73
K I ITGAS GIG ++ + + Y K
Sbjct: 3 KVILITGASRGIGLQLVKTVIEEDDECIVYGVARTEAGLQSLQRE-----YGADKFVYRV 57
Query: 74 LDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSE-DIKG---MIDTNVV 129
LD+T+ +++ ++ + ++ +D ++ NAG + +SE DIK + D N
Sbjct: 58 LDITDRSRMEALVEEIRQKHGKLDGIVANAGMLEPVKSISQSNSEHDIKQWERLFDVNFF 117
Query: 130 ALINVTQAVLPIFKAKNS-GDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKELIN 188
+++++ LP+ K+ G+IV + S A Y S Y SK A+ F + E +
Sbjct: 118 SIVSLVALCLPLLKSSPFVGNIVFVSSGASVKPYNGWSAYGCSKAALNHFAMDIASEEPS 177
Query: 189 TGIRVIEIAPGNVETE 204
+R + IAPG V+T+
Sbjct: 178 DKVRAVCIAPGVVDTQ 193
>At2g29370 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 268
Score = 57.8 bits (138), Expect = 2e-08
Identities = 57/233 (24%), Positives = 100/233 (42%), Gaps = 13/233 (5%)
Query: 11 LQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKVY 70
L+ T +TG S G+G+A +E L V V
Sbjct: 16 LEGMTALVTGGSKGLGKAV-VEELAMLGARVHTCARDETQLQESLREWQAKGLQVTTSV- 73
Query: 71 IGQLDVTETEKIQPFIDNLPEEFKD-IDILINNAGKALGSDVVGTISSEDIKGMIDTNVV 129
DV+ ++ + ++ + F+ + IL+ N G + ++E+ +I TN+
Sbjct: 74 ---CDVSSRDQREKLMETVSSLFQGKLSILVPNVGIGVLKPTT-ECTAEEFSFIIATNLE 129
Query: 130 ALINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKELINT 189
+ + +Q P+ KA SG+IV + SVAG SIY A+K A+ ++L E +
Sbjct: 130 STFHFSQLAHPLLKASGSGNIVLMSSVAGVVNLGNTSIYGATKGAMNQLARNLACEWASD 189
Query: 190 GIRVIEIAPGNVETEFSLVRYKGDADRAKQVYKGTTPL----YADDIADLIVY 238
IR + P + T S + GD D K+ + TPL A++++ L+ +
Sbjct: 190 NIRANSVCPWFITTP-STKDFLGDKD-VKEKVESVTPLRRVGEANEVSSLVAF 240
>At2g29320 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 269
Score = 57.8 bits (138), Expect = 2e-08
Identities = 57/197 (28%), Positives = 82/197 (40%), Gaps = 12/197 (6%)
Query: 11 LQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKVY 70
LQ T +TGA++GIG A +E L + V
Sbjct: 13 LQGMTALVTGAASGIGYAI-VEELAGFGAKIHICDISKTLLNQSLSEWENKGFQVSGSV- 70
Query: 71 IGQLDVT---ETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTN 127
DVT E EK+ + ++ + ++IL+NN G G ++ +D I TN
Sbjct: 71 ---CDVTSHPEREKLMQTVSSIFDG--KLNILVNNVGVLRGKPTTEYVA-DDFTFHISTN 124
Query: 128 VVALINVTQAVLPIFKAKNSGDIVNLGSVAG-RDAYPTGSIYCASKHAVRAFTQSLRKEL 186
+ A + Q P+ KA G IV L SVAG GSIY +K A+ ++L E
Sbjct: 125 LEAAYHFCQLSHPLLKASGYGSIVFLSSVAGVVSLIDCGSIYGLTKGALNQLARNLACEW 184
Query: 187 INTGIRVIEIAPGNVET 203
GIR +AP V+T
Sbjct: 185 AKDGIRANAVAPNVVKT 201
>At1g54870 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 286
Score = 57.8 bits (138), Expect = 2e-08
Identities = 40/129 (31%), Positives = 63/129 (48%), Gaps = 2/129 (1%)
Query: 75 DVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNVVALINV 134
D+ E + +D + F ID+LINNA + S + I ++ + TN+ + +
Sbjct: 99 DLGFDENCKRVVDEVVNAFGRIDVLINNAAEQYESSTIEEIDEPRLERVFRTNIFSYFFL 158
Query: 135 TQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKELINTGIRVI 194
T+ L K +S I+N SV + Y A+K A+ AFT+ L +L GIRV
Sbjct: 159 TRHALKHMKEGSS--IINTTSVNAYKGNASLLDYTATKGAIVAFTRGLALQLAEKGIRVN 216
Query: 195 EIAPGNVET 203
+APG + T
Sbjct: 217 GVAPGPIWT 225
>7304177 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 300
Score = 57.8 bits (138), Expect = 2e-08
Identities = 52/205 (25%), Positives = 80/205 (38%), Gaps = 18/205 (8%)
Query: 14 KTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKVYIGQ 73
K +TGA+ GIG+ T LE A G Q ++ +
Sbjct: 15 KVFIVTGANTGIGKETVLEI--AKRGGTVYMACRDMNRCEKARQDIIRETNNQ-NIFSRE 71
Query: 74 LDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNVVALIN 133
LD++ E I+ F +E + +LINNAG T++ + + + N +
Sbjct: 72 LDLSSLESIRKFAAGFKKEQDKLHVLINNAGVM---HCPRTLTKDGFEMQLGVNHMGHFL 128
Query: 134 VTQAVLPIFKAKNSGDIVNLGSVA------------GRDAYPTGSIYCASKHAVRAFTQS 181
+T +L + K IVN+ S+ +Y Y SK A FT+
Sbjct: 129 LTHLLLDVLKKTAPSRIVNVSSLVHTQGFIKTADLNSEKSYSRIGAYSQSKLANVLFTRE 188
Query: 182 LRKELINTGIRVIEIAPGNVETEFS 206
L K L TG+ + PG V+TE S
Sbjct: 189 LAKRLEGTGVTTNSLHPGAVDTELS 213
>At2g29290 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 262
Score = 57.4 bits (137), Expect = 2e-08
Identities = 54/233 (23%), Positives = 100/233 (42%), Gaps = 13/233 (5%)
Query: 11 LQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKVY 70
LQ +TG + GIG+A +E L V +
Sbjct: 7 LQGMNALVTGGTKGIGEAV-VEELSILGARVHTCARDETQLQERLREWQEKGFQVTTSI- 64
Query: 71 IGQLDVTETEKIQPFIDNLPEEFKD-IDILINNAGKALGSDVVGTISSEDIKGMIDTNVV 129
DV+ E+ + ++ + F+ ++IL+NN G + ++E+ ++ TN+
Sbjct: 65 ---CDVSLREQREKLMETVSSLFQGKLNILVNNVGTLMLKPTT-EYTAEEFSFLMATNLD 120
Query: 130 ALINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKELINT 189
+ +++Q P+ KA SG IV + S+AG GSIY A+K A+ ++L E +
Sbjct: 121 SAFHISQLAHPLLKASGSGSIVLMSSIAGVVHVGVGSIYGATKGAMNQLARNLACEWASD 180
Query: 190 GIRVIEIAPGNVETEFSLVRYKGDADRAKQVYKGTTPL----YADDIADLIVY 238
IR I P + T L+ + K+ + TP+ A++++ L+ +
Sbjct: 181 NIRTNAICPWLITT--PLISDLLSVEEMKKEAEERTPMGRVGEANEVSPLVAF 231
>7301303 [Q] KOG1210 Predicted 3-ketosphinganine reductase
Length = 336
Score = 57.4 bits (137), Expect = 2e-08
Identities = 49/199 (24%), Positives = 79/199 (39%), Gaps = 3/199 (1%)
Query: 6 KAAERLQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYP 65
K + + + +TG S GIG A+E NV P
Sbjct: 28 KKPRSIVGRHVVVTGGSKGIGLCLAVECA-MKGANVTVIARDEKMLSGAVALMEVIRQRP 86
Query: 66 QAKVYIGQLDVT-ETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMI 124
K LD++ + +++ + + + F I LIN AG A+ V +S +D+ ++
Sbjct: 87 DQKFQYRSLDISGDYDQVAKVLGEIEDSFGPIYTLINCAGMAI-CGVFEEVSVQDVHKLM 145
Query: 125 DTNVVALINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRK 184
+ N N T+ VLP K G IV S A Y A+K+A+RA +++
Sbjct: 146 NVNFFGTYNCTRYVLPKMKKAGDGIIVITASQAAMFGIYGYGPYSATKYALRAMAETIAM 205
Query: 185 ELINTGIRVIEIAPGNVET 203
E G+ V P + T
Sbjct: 206 ESREHGVSVTLAMPCDTNT 224
>7294121 [IR] KOG4169 15-hydroxyprostaglandin dehydrogenase and related
dehydrogenases
Length = 482
Score = 57.4 bits (137), Expect = 2e-08
Identities = 39/145 (26%), Positives = 65/145 (43%), Gaps = 14/145 (9%)
Query: 64 YPQAKVYIGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGM 123
+P +++ ++D+T+ I E+ D+++N +G + I+
Sbjct: 267 HPDTEIFYQKMDITQKSDIDAAYKATAEKLGHFDVVVNGSG---------LLDDRRIELT 317
Query: 124 IDTNVVALINVTQAVLPIF---KAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQ 180
I N+V +IN T L K G IVN+ SVAG P +IY SK V FT+
Sbjct: 318 IQINLVGVINSTLTALEYMDKSKGGRGGLIVNISSVAGLQPTPLMAIYSTSKTGVTTFTR 377
Query: 181 SLRKEL--INTGIRVIEIAPGNVET 203
++ + ++G+ I I PG T
Sbjct: 378 AMASPIHYAHSGVGFITICPGYTNT 402
Score = 55.5 bits (132), Expect = 8e-08
Identities = 47/195 (24%), Positives = 78/195 (39%), Gaps = 12/195 (6%)
Query: 11 LQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKVY 70
L K + G GIGQ E L +P V+
Sbjct: 3 LAGKNVVYLGGFGGIGQKCVQELLQRP----IKALAIFDLNANEQLLAKWKSQHPDTDVF 58
Query: 71 IGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNVVA 130
+LD+T+ I E F D+++N +G + +V ++ G+I++ + A
Sbjct: 59 YHKLDITQKSDIDAAYKATAERFGHFDVVVNGSG-LMNDRLVELTIQINLLGVINSTLTA 117
Query: 131 LINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKELI--N 188
L + +A K G IVN+ SVAG +IY A+K V FT+++ +
Sbjct: 118 LEYMDKA-----KGGKGGLIVNISSVAGLQPTAIMAIYSAAKTGVTTFTRAMANPYFYAH 172
Query: 189 TGIRVIEIAPGNVET 203
+G+ + I PG +T
Sbjct: 173 SGVGFLTICPGFTDT 187
>7298168 [IR] KOG4169 15-hydroxyprostaglandin dehydrogenase and related
dehydrogenases
Length = 272
Score = 57.0 bits (136), Expect = 3e-08
Identities = 45/142 (31%), Positives = 65/142 (45%), Gaps = 17/142 (11%)
Query: 65 PQAKVYIGQLDVTET-EKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSED-IKG 122
P +++ DVT E ++ + D + + ID+LIN A T+ E+ I
Sbjct: 54 PSTQIFFWTYDVTMAREDMKKYFDEVMVQMDYIDVLINGA----------TLCDENNIDA 103
Query: 123 MIDTNVVALINVTQAVLPIFKAKNSGD---IVNLGSVAGRDAYPTGSIYCASKHAVRAFT 179
I+TN+ ++N VLP K G IVN+ SV G D P Y ASK V FT
Sbjct: 104 TINTNLTGMMNTVATVLPYMDRKMGGTGGLIVNVTSVIGLDPSPVFCAYSASKFGVIGFT 163
Query: 180 QSLRKELI--NTGIRVIEIAPG 199
+SL L G+ V+ + G
Sbjct: 164 RSLADPLYYSQNGVAVMAVCCG 185
>SPAC4H3.08 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 286
Score = 56.6 bits (135), Expect = 4e-08
Identities = 48/194 (24%), Positives = 83/194 (42%), Gaps = 5/194 (2%)
Query: 10 RLQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKV 69
+L K +TG +GIG+A A+ + + V +
Sbjct: 39 KLAEKKTLLTGGDSGIGKAAAVMFAREGSDLVISCLPEERDDAEVTRDLIEREGR-NCWI 97
Query: 70 YIGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNVV 129
+ G+LD +++ + +D ++ ID+L+NN + + I E TN+
Sbjct: 98 WEGKLD--KSDNCRDLVDFALKKLGWIDVLVNNIAYQQVAQSIEDIDDEQWDLTFKTNIF 155
Query: 130 ALINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKELINT 189
+ VT+A + K+ +S IVN S+ P Y ++K A+ AFT+ L +
Sbjct: 156 SFFWVTKAAISHMKSGSS--IVNCSSINAYVGRPDLLDYTSTKGAITAFTRGLSNQYAQH 213
Query: 190 GIRVIEIAPGNVET 203
GIRV +APG + T
Sbjct: 214 GIRVNAVAPGPIYT 227
>SPAC23D3.11 [Q] KOG1209 1-Acyl dihydroxyacetone phosphate reductase and related
dehydrogenases
Length = 296
Score = 56.6 bits (135), Expect = 4e-08
Identities = 52/195 (26%), Positives = 90/195 (45%), Gaps = 19/195 (9%)
Query: 14 KTIFITGAS-AGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKVYIG 72
K + ITG S GIG A AL++ +A +
Sbjct: 5 KFVLITGCSEGGIGNALALKFHQEG-----------FQVLATARQVERMDNLTKAGLQTL 53
Query: 73 QLDVTETEKIQPFIDNLPEEFKD--IDILINNAGKALGSDVVGTISSEDIKGMIDTNVVA 130
+LDVT+ + ++ ++ +F + + LINNAG + + + ED+ ++D N
Sbjct: 54 KLDVTDEDSVRE-VEQEVRKFTNGSLHYLINNAGAPCSAPAID-LDIEDVSKVMDVNFYG 111
Query: 131 LINVTQAVL-PIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKELINT 189
+I + +A + +AK G IVN+ S+ + + Y ASK A+ A++ +LR EL
Sbjct: 112 VIRMNKAFQHQLIRAK--GTIVNVNSLVSYVPFAFNAAYNASKAALLAYSNTLRIELAPF 169
Query: 190 GIRVIEIAPGNVETE 204
G++V I G V+T+
Sbjct: 170 GVQVTSIMTGGVQTK 184
>Hs5031765 [Q] KOG1205 Predicted dehydrogenase
Length = 292
Score = 56.6 bits (135), Expect = 4e-08
Identities = 57/211 (27%), Positives = 90/211 (42%), Gaps = 18/211 (8%)
Query: 9 ERLQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAK 68
E LQ K + +TGAS GIG+ A Y A G A
Sbjct: 30 EMLQGKKVIVTGASKGIGREMA--YHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAH 87
Query: 69 VYIGQL-DVTETEKIQPFIDNLPEEFKDIDILI----NNAGKALGSDVVGTISSEDIKGM 123
G + D+T E+ F+ + +D+LI N L D + ++
Sbjct: 88 YIAGTMEDMTFAEQ---FVAQAGKLMGGLDMLILNHITNTSLNLFHDDI-----HHVRKS 139
Query: 124 IDTNVVALINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLR 183
++ N ++ + +T A LP+ K N G IV + S+AG+ AYP + Y ASK A+ F S+R
Sbjct: 140 MEVNFLSYVVLTVAALPMLKQSN-GSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIR 198
Query: 184 KE--LINTGIRVIEIAPGNVETEFSLVRYKG 212
KE + + + G ++TE ++ G
Sbjct: 199 KEYSVSRVNVSITLCVLGLIDTETAMKAVSG 229
>At2g29360 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 271
Score = 56.6 bits (135), Expect = 4e-08
Identities = 49/194 (25%), Positives = 82/194 (42%), Gaps = 7/194 (3%)
Query: 11 LQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKVY 70
L T +TG S GIG+A +E L + V
Sbjct: 16 LVGMTALVTGGSKGIGEAV-VEELATLGARIHTCARDETQLQESLRKWQAKGFQVTTSV- 73
Query: 71 IGQLDVTETEKIQPFIDNLPEEFKD-IDILINNAGKALGSDVVGTISSEDIKGMIDTNVV 129
DV+ +K + ++ + F+ ++IL+NN G + + ++ED + TN+
Sbjct: 74 ---CDVSSRDKREKLMETVSTIFEGKLNILVNNVGTCIVKPTLQH-TAEDFSFTMATNLE 129
Query: 130 ALINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKELINT 189
+ +++Q P+ KA SG IV + SV+G SIY SK A+ ++L E +
Sbjct: 130 SAFHLSQLAHPLLKASGSGSIVLISSVSGVVHVNGASIYGVSKGAMNQLGRNLACEWASD 189
Query: 190 GIRVIEIAPGNVET 203
IR + P +ET
Sbjct: 190 NIRTNSVCPWFIET 203
>At1g52340 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 285
Score = 56.6 bits (135), Expect = 4e-08
Identities = 53/206 (25%), Positives = 85/206 (40%), Gaps = 16/206 (7%)
Query: 75 DVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDV--VGTISSEDIKGMIDTNVVALI 132
DV + I +D + F +DILINNAG G+ + S + + D NV
Sbjct: 79 DVRVEDDISNAVDFAVKNFGTLDILINNAGLC-GAPCPDIRNYSLSEFEMTFDVNVKGAF 137
Query: 133 NVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKELINTGIR 192
+ + + G IV+L SV G Y SKHAV T+S+ EL GIR
Sbjct: 138 LSMKHAARVMIPEKKGSIVSLCSVGGVVGGVGPHSYVGSKHAVLGLTRSVAAELGQHGIR 197
Query: 193 VIEIAPGNVETEFSLVRYKGDADRAKQVYKG------------TTPLYADDIADLIVYAT 240
V ++P V T+ +L + + +R + + G L DD+A+ +++
Sbjct: 198 VNCVSPYAVATKLALA-HLPEEERTEDAFVGFRNFAAANANLKGVELTVDDVANAVLFLA 256
Query: 241 SRKPNTVIADVLVFASNQASPYHIYR 266
S + D L+ H ++
Sbjct: 257 SDDSRYISGDNLMIDGGFTCTNHSFK 282
>CE09505 [R] KOG1611 Predicted short chain-type dehydrogenase
Length = 249
Score = 56.2 bits (134), Expect = 5e-08
Identities = 57/210 (27%), Positives = 89/210 (42%), Gaps = 27/210 (12%)
Query: 14 KTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKVYIGQ 73
K++ ITGA+ GIG ++L + + ++++I
Sbjct: 4 KSLLITGANRGIGLGLLKQFLKHKDIQIIIATCRDPSKAEELSNLK------DSRLHILP 57
Query: 74 LDVTETEKIQPF---IDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNVVA 130
LD+ E I ++ L E + +L+NNAG L DV G + + + ++TN V+
Sbjct: 58 LDIDCDESISKLYAEVEKLVGE-DGLTVLLNNAGILLPYDVEGEKNRKTLIRQLETNSVS 116
Query: 131 LINVTQAVLPIFK---AKNSGD--------IVNLGSVAGRDAYPTGSI------YCASKH 173
+TQ LP+ K AKN GD IVN+ S A G+ Y SK
Sbjct: 117 TALITQEFLPLLKKAAAKNGGDGYSINRAAIVNISSTAASVEKIDGTFNGPLVAYRMSKS 176
Query: 174 AVRAFTQSLRKELINTGIRVIEIAPGNVET 203
A+ +F +S +L I V PG V+T
Sbjct: 177 ALNSFAKSCSIDLAKYHILVTSFCPGWVKT 206
>7295674 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 325
Score = 56.2 bits (134), Expect = 5e-08
Identities = 48/187 (25%), Positives = 78/187 (41%), Gaps = 5/187 (2%)
Query: 11 LQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKVY 70
+ + + ITG G+G+ AL + V Y K Y
Sbjct: 54 ISGQVVLITGGGGGVGRLIALNFARLQARIVIWDINQEAIKTTVDLLAKHG--YDNCKGY 111
Query: 71 IGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNVVA 130
+ +D+++ E+I + EE +DILINNAG + + I+ + N+++
Sbjct: 112 V--VDISDREQIYQRASQVTEEVGPVDILINNAG-IVCCKPFWELHDRVIQNTYNINIIS 168
Query: 131 LINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKELINTG 190
+A LP N G IV +GSV G S Y A+K+A F +SL +L G
Sbjct: 169 HYWTVKAFLPHMMRNNRGHIVTVGSVTGMLGTYGCSDYAATKYACIGFHESLLTDLKAHG 228
Query: 191 IRVIEIA 197
I+++
Sbjct: 229 YDQIQMS 235
>YLR426w [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 326
Score = 55.8 bits (133), Expect = 6e-08
Identities = 51/204 (25%), Positives = 88/204 (43%), Gaps = 18/204 (8%)
Query: 6 KAAERLQNKTIFITGASAGIGQATALEYL-DAANGNVXXXXXXXXXXXXXXXXXXXXXXY 64
K+ +N + ITG S G+G+A + L D +N +
Sbjct: 63 KSLREFKNGIVLITGGSKGLGRAIVSQLLQDYSNLTILNVDICPSSVRNT---------- 112
Query: 65 PQAKVYIGQLDVTETEKIQPFIDNLPEEFK-DIDILINNAGKALGSDVVGTISSEDIKGM 123
+ K I D+++ E++ ++ L ++K +I +++NNAG + +++ +
Sbjct: 113 -RVKDLI--CDLSDDEEVAALLNLLKRKYKNEIRLIVNNAGVRANFTGFNGMERDNLDKI 169
Query: 124 IDTNVVALINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLR 183
N A + Q + P + IVN+ S+ G + Y ASK A+ AF QS
Sbjct: 170 FKINTFAPLQFIQELAPSRHSTRQCYIVNIASILGILTPAKVAAYAASKAALIAFHQSYS 229
Query: 184 KELINTGIRVIE---IAPGNVETE 204
EL N G+R I + PG + TE
Sbjct: 230 FELQNEGVRNIRTLLVTPGQLNTE 253
>YDL114w [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 308
Score = 55.8 bits (133), Expect = 6e-08
Identities = 47/199 (23%), Positives = 84/199 (41%), Gaps = 18/199 (9%)
Query: 12 QNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKVYI 71
+N T ITG S+G+G A E N + ++
Sbjct: 37 KNATALITGGSSGLGFELAKELSRRINKVIVADIQSFPTFAQVEYN----------NIFY 86
Query: 72 GQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNVVAL 131
Q D+T ++I+ + + +I+I+INNAG A + +++++++ +ID N++
Sbjct: 87 YQCDITSLDEIKNLKKAIERDHGNINIIINNAGVA-HIKKLEHMTNKEVEQLIDINLIGA 145
Query: 132 INVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAF-------TQSLRK 184
+ G I+N+ SV G + Y ASK A+ F +SL
Sbjct: 146 YRIISTFAEDMIDNREGFIINIASVLGELTPARLTSYGASKGAMIGFHKCMSRHFRSLST 205
Query: 185 ELINTGIRVIEIAPGNVET 203
E TGI+ + + PG ++T
Sbjct: 206 ECNKTGIKTLLVCPGKIKT 224
>Hs7705855 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 312
Score = 55.8 bits (133), Expect = 6e-08
Identities = 38/118 (32%), Positives = 64/118 (54%), Gaps = 3/118 (2%)
Query: 95 DIDILINNAGKALG-SDVVGTISSED--IKGMIDTNVVALINVTQAVLPIFKAKNSGDIV 151
+I IL+NN G + + + D IK MI+ N++++ +TQ VLP ++ G I+
Sbjct: 126 EIGILVNNVGMSYEYPEYFLDVPDLDNVIKKMININILSVCKMTQLVLPGMVERSKGAIL 185
Query: 152 NLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKELINTGIRVIEIAPGNVETEFSLVR 209
N+ S +G P +IY A+K V F+Q L +E + G+ V + P V T+ + +R
Sbjct: 186 NISSGSGMLPVPLLTIYSATKTFVDFFSQCLHEEYRSKGVFVQSVLPYFVATKLAKIR 243
>At3g51680 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 303
Score = 55.8 bits (133), Expect = 6e-08
Identities = 68/265 (25%), Positives = 107/265 (39%), Gaps = 25/265 (9%)
Query: 9 ERLQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAK 68
+RL+ K ITG + GIG+AT + L A +G
Sbjct: 30 KRLEGKVAIITGGAHGIGKATVM--LFARHGATVVIADVDNVAGSSLAKSLSSHKTSPMV 87
Query: 69 VYIGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDV----VGTISSEDIKGMI 124
+I DV+ ++ ++ + +DIL NNAG LG + +++ ++
Sbjct: 88 AFIS-CDVSVEADVENLVNVTVARYGRLDILFNNAG-VLGDQKKHKSILDFDADEFDHVM 145
Query: 125 DTNVVAL-INVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLR 183
NV + + + + K G I++ SVAG Y ASKHA+ T++
Sbjct: 146 RVNVRGVGLGMKHGARAMIKRGFKGCIISTASVAGVMGGMGPHAYTASKHAIVGLTKNAA 205
Query: 184 KELINTGIRVIEIAPGNVETEFSLVRYK----GDAD-----------RAKQVYKGTTPLY 228
EL GIRV I+P V T + ++ GD + R+ KG T L
Sbjct: 206 CELGKYGIRVNCISPFGVATSMLVNAWRKTSGGDVEDDDVEEMEEFVRSLANLKGET-LR 264
Query: 229 ADDIADLIVYATSRKPNTVIADVLV 253
A+DIA+ +Y S + V LV
Sbjct: 265 ANDIAEAALYLASDESKYVNGHNLV 289
>At2g29340 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 262
Score = 55.8 bits (133), Expect = 6e-08
Identities = 48/197 (24%), Positives = 81/197 (40%), Gaps = 7/197 (3%)
Query: 11 LQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKVY 70
L+ T +TG ++GIG A +E L + V
Sbjct: 7 LKGMTALVTGGASGIGYAI-VEELAGFGARIHVCDISEAKLNQSLSEWEKKGFQVSGSV- 64
Query: 71 IGQLDVTETEKIQPFIDNLPEEFKD-IDILINNAGKALGSDVVGTISSEDIKGMIDTNVV 129
DV + + + + +F ++IL++N G + S + +D I +NV
Sbjct: 65 ---CDVASRPEREELMQTVSSQFDGKLNILVSNVG-VIRSKPTTEYTEDDFAFHISSNVE 120
Query: 130 ALINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKELINT 189
A + +Q P+ KA G I+ + S+AG ++ GSIY +K A+ ++L E
Sbjct: 121 AAYHFSQLSHPLLKASGYGSIIFVSSIAGVISFDAGSIYGLTKGALIQLAKNLACEWAKD 180
Query: 190 GIRVIEIAPGNVETEFS 206
GIR +AP + T S
Sbjct: 181 GIRANAVAPNVINTPLS 197
>7304180 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 327
Score = 55.8 bits (133), Expect = 6e-08
Identities = 48/205 (23%), Positives = 80/205 (38%), Gaps = 18/205 (8%)
Query: 14 KTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKVYIGQ 73
K +TG + G+G+ T +E A + V+ +
Sbjct: 46 KVAIVTGGNTGLGKETVMEL---ARRGATVYMACRNKEKVERARREIVKETGNSNVFSRE 102
Query: 74 LDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNVVALIN 133
D++ + I+ F +N +E + + ILINNAG ++ E + + N +
Sbjct: 103 CDLSSLDSIRKFAENFKKEQRVLHILINNAGVFWEPH---RLTKEGFEMHLGVNHIGHFL 159
Query: 134 VTQAVLPIFKAKNSGDIVNLGSVA------------GRDAYPTGSIYCASKHAVRAFTQS 181
+T +L + + +V + S A D Y G YC SK A FT+
Sbjct: 160 LTNLLLGVLERSAPSRVVVVASRAHERGQIKVDDINSSDFYDEGVAYCQSKLANILFTRE 219
Query: 182 LRKELINTGIRVIEIAPGNVETEFS 206
L K L TG+ V + PG +TE +
Sbjct: 220 LAKRLEGTGVTVNALNPGIADTEIA 244
>Hs4504499 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 405
Score = 55.1 bits (131), Expect = 1e-07
Identities = 54/218 (24%), Positives = 92/218 (41%), Gaps = 17/218 (7%)
Query: 14 KTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKVYIGQ 73
+ + ITG +G G+ TA + LD+ V ++ + Q
Sbjct: 83 RAVLITGCDSGFGKETAKK-LDSMGFTVLATVLELNSPGAIELRTCCS-----PRLRLLQ 136
Query: 74 LDVTETEKIQPFIDNLPEEFKDIDI--LINNAGKALGSDVVGTISSEDI---KGMIDTNV 128
+D+T+ I ++ + L+NNAG ++VV + + ++ N
Sbjct: 137 MDLTKPGDISRLLEFTKAHTTSTGLWGLVNNAGH---NEVVADAELSPVATFRSCMEVNF 193
Query: 129 VALINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKELIN 188
+ +T+ +LP+ ++ G IV +GS AG YP Y SK AV + EL+
Sbjct: 194 FGALELTKGLLPLLRSSR-GRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLP 252
Query: 189 TGIRVIEIAPGNVETEFSLVRYKGDADRAKQVYKGTTP 226
G++V I PG +TE VR G ++ KQ+ P
Sbjct: 253 WGVKVSIIQPGCFKTE--SVRNVGQWEKRKQLLLANLP 288
>7296704 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 264
Score = 55.1 bits (131), Expect = 1e-07
Identities = 58/208 (27%), Positives = 90/208 (42%), Gaps = 16/208 (7%)
Query: 1 MSQGRKAAERLQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXX 60
M KA K + ITGA++GIG A A E +
Sbjct: 1 MGSKGKAGLDFSGKVVLITGAASGIGAAAA-EMFSKLGACLALVDREEEGLICVMKRCMK 59
Query: 61 XXXYPQAKVYIGQLDVTETEKIQPFIDNLPEEFKD-IDILINNAGKALGSDVVGTISSED 119
P Y D+ + +I+ E ++ +D+L+N AG GT+ S +
Sbjct: 60 MGHEP----YGIAGDLLKPPEIECIARKTTERYEGKLDVLVNGAGIM----PTGTLQSTE 111
Query: 120 IK---GMIDTNVVALINVTQAVLP-IFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAV 175
+ +++ NV + +T+ +LP + + K G IVN+ SV G A+P Y SK AV
Sbjct: 112 LACFTHVMEANVRSGFYLTKLLLPQLLQCK--GSIVNVSSVCGLRAFPNLVAYNMSKAAV 169
Query: 176 RAFTQSLRKELINTGIRVIEIAPGNVET 203
FT+SL +L G+RV + PG + T
Sbjct: 170 DQFTRSLALDLGPQGVRVNAVNPGVIRT 197
>YKR009c [I] KOG1206 Peroxisomal multifunctional beta-oxidation protein and
related enzymes
Length = 900
Score = 54.7 bits (130), Expect = 1e-07
Identities = 47/196 (23%), Positives = 83/196 (41%), Gaps = 8/196 (4%)
Query: 3 QGRKAAERLQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXX 62
QG + L NK + +TGA G+G++ A+ +
Sbjct: 312 QGSVKIKSLCNKVVVVTGAGGGLGKSHAIWF-----ARYGAKVVVNDIKDPFSVVEEINK 366
Query: 63 XYPQAKVYIGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKG 122
Y + DV + I +F+ +DIL+NNAG + + E+
Sbjct: 367 LYGEGTAIPDSHDVVTEAPL--IIQTAISKFQRVDILVNNAGILRDKSFL-KMKDEEWFA 423
Query: 123 MIDTNVVALINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSL 182
++ ++ + ++++AV PIF + SG I+N S +G + Y A+K A+ F++++
Sbjct: 424 VLKVHLFSTFSLSKAVWPIFTKQKSGFIINTTSTSGIYGNFGQANYAAAKAAILGFSKTI 483
Query: 183 RKELINTGIRVIEIAP 198
E GI V IAP
Sbjct: 484 ALEGAKRGIIVNVIAP 499
>Hs4758504 [Q] KOG1199 Short-chain alcohol dehydrogenase/3-hydroxyacyl-CoA
dehydrogenase
Length = 261
Score = 54.7 bits (130), Expect = 1e-07
Identities = 50/204 (24%), Positives = 80/204 (38%), Gaps = 19/204 (9%)
Query: 7 AAERLQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQ 66
A ++ ITG ++G+G ATA + V P
Sbjct: 4 ACRSVKGLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVFAPA 63
Query: 67 AKVYIGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVG-----TISSEDIK 121
DVT + +Q + +F +D+ +N AG A+ S T + ED +
Sbjct: 64 --------DVTSEKDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQ 115
Query: 122 GMIDTNVVALINVTQAVLPIF------KAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAV 175
++D N++ NV + V + G I+N SVA + + Y ASK +
Sbjct: 116 RVLDVNLMGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGI 175
Query: 176 RAFTQSLRKELINTGIRVIEIAPG 199
T + ++L GIRV+ IAPG
Sbjct: 176 VGMTLPIARDLAPIGIRVMTIAPG 199
>CE03127 [Q] KOG1199 Short-chain alcohol dehydrogenase/3-hydroxyacyl-CoA
dehydrogenase
Length = 258
Score = 54.3 bits (129), Expect = 2e-07
Identities = 42/139 (30%), Positives = 63/139 (45%), Gaps = 11/139 (7%)
Query: 76 VTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGT-----ISSEDIKGMIDTNVVA 130
VT E+++ + E+ +D L+N AG A + + E I+ ID NV+
Sbjct: 62 VTSEEEVRAAFAKVQAEYGRLDALVNCAGIAYAFKLYSVQKKKHVDFEKIRQTIDVNVLG 121
Query: 131 LINVTQAVLPIF----KAKNS--GDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRK 184
NV + + + K N G ++N SVA D S Y ASK A+ T L +
Sbjct: 122 TFNVIRHGVALMGEHEKDANGQRGVVINTASVAAFDGQTGQSAYSASKGAIVGMTLPLAR 181
Query: 185 ELINTGIRVIEIAPGNVET 203
+ GIR IAPG ++T
Sbjct: 182 DFAGDGIRFNTIAPGLMDT 200
>Hs4759084 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 302
Score = 53.9 bits (128), Expect = 2e-07
Identities = 49/195 (25%), Positives = 76/195 (38%), Gaps = 6/195 (3%)
Query: 11 LQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKVY 70
L + + ITG GIG+ A E+ + + + +
Sbjct: 36 LSRENVLITGGGRGIGRQLAREFAERGARKIVLWGRTEKCLKETTEEIRQMGT--ECHYF 93
Query: 71 IGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNVVA 130
I DV E++ + E+ DI IL+NNA G ++ + +K N +
Sbjct: 94 I--CDVGNREEVYQTAKAVREKVGDITILVNNAAVVHGKSLMDSDDDALLKSQ-HINTLG 150
Query: 131 LINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKELIN-T 189
T+A LP +G IV L SV A P YC SK + AF +SL L++
Sbjct: 151 QFWTTKAFLPRMLELQNGHIVCLNSVLALSAIPGAIDYCTSKASAFAFMESLTLGLLDCP 210
Query: 190 GIRVIEIAPGNVETE 204
G+ + P + TE
Sbjct: 211 GVSATTVLPFHTSTE 225
>CE07962 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 349
Score = 53.9 bits (128), Expect = 2e-07
Identities = 38/114 (33%), Positives = 57/114 (49%), Gaps = 3/114 (2%)
Query: 96 IDILINNAGKALG--SDVVGTISSEDIKGMIDT-NVVALINVTQAVLPIFKAKNSGDIVN 152
I +LINN G ++ T+ D+ + N + + ++ +LP ++ +G IVN
Sbjct: 127 IGMLINNVGMLFEYPENLHKTVGGIDVVANVTILNTLPVTLLSAGILPQMVSRKTGIIVN 186
Query: 153 LGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKELINTGIRVIEIAPGNVETEFS 206
+GSVAG S+Y ASK V T LRKE + GI + I P V T+ S
Sbjct: 187 IGSVAGAAKMAEWSVYSASKKYVEWLTGCLRKEYEHQGIIIQAITPALVATKLS 240
>At4g13250 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 447
Score = 53.9 bits (128), Expect = 2e-07
Identities = 46/166 (27%), Positives = 80/166 (47%), Gaps = 14/166 (8%)
Query: 67 AKVYIGQLDVTETEKIQPFIDNLPEEFKDIDI---------LINNAGKALGSDVVGTISS 117
AKV DV + E ++ + +E I+I INNAG G + +
Sbjct: 169 AKVVGIACDVCKPEDVEKLSNFAVKELGSINIWVKKHISFCTINNAGTNKGFRPLLEFTE 228
Query: 118 EDIKGMIDTNVVALINVTQAVLPIFKAKNS-GDIVNL-GSVAGRDAYPTGSIYCASKHAV 175
EDI ++ TN++ I T+ + + ++S G I N+ G+ +G + P ++Y ++K +
Sbjct: 229 EDITQIVSTNLIGSILCTRGAMDVMSRQHSGGHIFNMDGAGSGGSSTPLTAVYGSTKCGL 288
Query: 176 RAFTQSLRKELINTGIRVIEIAPGNVETEFSLVRYKGDADRAKQVY 221
R F S+ KE T + + +PG V TE L G + + KQ++
Sbjct: 289 RQFHGSIVKESQKTNVGLHTASPGMVLTELLL---SGSSIKNKQMF 331
>7298352 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 339
Score = 53.9 bits (128), Expect = 2e-07
Identities = 34/113 (30%), Positives = 57/113 (50%), Gaps = 1/113 (0%)
Query: 95 DIDILINNAGKALGSDVVGTISSEDIK-GMIDTNVVALINVTQAVLPIFKAKNSGDIVNL 153
D+ IL+NN G + SED+ ++ N+ ++ +T+ +LP + G IVNL
Sbjct: 147 DVGILVNNVGMMYEHPESLDLVSEDLLWNLLTVNMGSVTMLTRKILPQMIGRRKGAIVNL 206
Query: 154 GSVAGRDAYPTGSIYCASKHAVRAFTQSLRKELINTGIRVIEIAPGNVETEFS 206
GS + P ++Y ASK V F+++L E+ I V + P V T+ +
Sbjct: 207 GSSSELQPLPNMTVYAASKKFVTYFSKALELEVAEHNIHVQLVMPNFVVTKMN 259
>At2g29330 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 260
Score = 53.5 bits (127), Expect = 3e-07
Identities = 32/108 (29%), Positives = 54/108 (49%), Gaps = 1/108 (0%)
Query: 96 IDILINNAGKALGSDVVGTISSEDIKGMIDTNVVALINVTQAVLPIFKAKNSGDIVNLGS 155
++IL+NN G + +ED +I TN+ + +++Q P+ KA +G I + S
Sbjct: 88 LNILVNNVGTIRTKPTI-EYEAEDFSFLISTNLESAYHLSQLSHPLLKASGNGIITFISS 146
Query: 156 VAGRDAYPTGSIYCASKHAVRAFTQSLRKELINTGIRVIEIAPGNVET 203
AG ++ SIY +K A+ ++L E GIR +AP + T
Sbjct: 147 AAGIVSFDAASIYGLTKGALNQLARNLACEWAKDGIRANAVAPNFITT 194
>At2g29300 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 263
Score = 53.5 bits (127), Expect = 3e-07
Identities = 63/236 (26%), Positives = 99/236 (41%), Gaps = 18/236 (7%)
Query: 11 LQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKVY 70
LQ T +TGA++GIG A +E L + V
Sbjct: 7 LQGMTALVTGAASGIGYAI-VEELAGFGARIHVCDISETLLNQSLREWEKKGFQVSGSV- 64
Query: 71 IGQLDVT---ETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTN 127
DVT E EK+ + +L + ++IL+NN G L + ++D I TN
Sbjct: 65 ---CDVTSRPEREKLMQTVSSLFDG--KLNILVNNVG-VLRAKPTTEYVADDFTFHISTN 118
Query: 128 VVALINVTQAVLPIFKAKNSGDIVNLGSVAG-RDAYPTGSIYCASKHAVRAFTQSLRKEL 186
+ A + Q P+ K G IV L SV+G GS+Y +K A+ ++L E
Sbjct: 119 LEAAYHFCQLSHPLLKTSGYGSIVFLSSVSGVVSITDCGSLYGLTKGALNQLARNLACEW 178
Query: 187 INTGIRVIEIAPGNVETEFSLVRYKGDADRAKQVYKGTTPL----YADDIADLIVY 238
GIR +AP V+T S + D + + ++ TPL +++A L+V+
Sbjct: 179 AKDGIRANAVAPNVVKTAQSQF-FLQDVSKKEGLF-SRTPLGRSGEPNEVASLVVF 232
>SPCC1739.08c [R] KOG0725 Reductases with broad range of substrate specificities
Length = 261
Score = 53.1 bits (126), Expect = 4e-07
Identities = 43/196 (21%), Positives = 90/196 (44%), Gaps = 9/196 (4%)
Query: 11 LQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKVY 70
L+ K + GA+ GIG + A + A GNV +V+
Sbjct: 19 LKGKNCVVFGAAKGIGFSIATAFAQAG-GNVIITYLTTDPTEKAKKLAEETG----VQVH 73
Query: 71 IGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNVVA 130
++D++ ++ ++ ++ + + FK+I +++ NAG V+ + + + +++ N +
Sbjct: 74 TLKIDISRSDTVEAGVEEIQKIFKEIHVVVANAGMPFRRSVLDS-PPHEFEKVMNINTNS 132
Query: 131 LINVTQAVLPIFKAKNSGDIVNLGSVAGR--DAYPTGSIYCASKHAVRAFTQSLRKELIN 188
+ V + IFK + G+++ S++ +A + YCASK AVR ++L E
Sbjct: 133 VYRVAYYMGKIFKKQGFGNLIATASMSATIVNAPQHIAAYCASKAAVRQLCKALAVEWAE 192
Query: 189 TGIRVIEIAPGNVETE 204
R+ ++PG T+
Sbjct: 193 FA-RINSVSPGYFATD 207
>Hs5032035 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 323
Score = 53.1 bits (126), Expect = 4e-07
Identities = 57/209 (27%), Positives = 88/209 (41%), Gaps = 14/209 (6%)
Query: 3 QGRKAAERLQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXX 62
+G+ E + +K IFITG +G G A + D +V
Sbjct: 19 KGKLKIEDITDKYIFITGCDSGFGNLAARTF-DKKGFHVIAACLTESGSTALKAET---- 73
Query: 63 XYPQAKVYIGQLDVTETEKIQ---PFIDNLPEEFKDIDILINNAGKALGSDVVGTISSED 119
++ LDVT+ E ++ ++ N E K + LINNAG ++ ED
Sbjct: 74 ---SERLRTVLLDVTDPENVKRTAQWVKNQVGE-KGLWGLINNAGVPGVLAPTDWLTLED 129
Query: 120 IKGMIDTNVVALINVTQAVLPIFKAKNSGD-IVNLGSVAGRDAYPT-GSIYCASKHAVRA 177
+ I+ N+ LI+VT +LP + G L S P+ G Y SK+AV
Sbjct: 130 YREPIEVNLFGLISVTLNMLPRPQEDQPGQGGTTLPSPCTAGKLPSVGGGYTPSKYAVEG 189
Query: 178 FTQSLRKELINTGIRVIEIAPGNVETEFS 206
F SLR+++ G+ V I PG +T +
Sbjct: 190 FNDSLRRDMKAFGVHVSCIEPGLFKTNLA 218
>At5g61830 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 316
Score = 53.1 bits (126), Expect = 4e-07
Identities = 38/95 (40%), Positives = 55/95 (57%), Gaps = 7/95 (7%)
Query: 68 KVYIGQLDVTETEKIQPFIDNLPEEFKDIDILINNAG--KALGSDVVGTISSEDIKGMID 125
KVY QLDVT++ I+ F L + F +DIL+NNAG LGSD T+ E + +I
Sbjct: 88 KVYFHQLDVTDSSSIREFGCWLKQTFGGLDILVNNAGVNYNLGSD--NTV--EFAETVIS 143
Query: 126 TNVVALINVTQAVLPIFKAKNSG-DIVNLGSVAGR 159
TN N+T+A++P+ + G +VN+ S GR
Sbjct: 144 TNYQGTKNMTKAMIPLMRPSPHGARVVNVSSRLGR 178
>At5g18210 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 261
Score = 53.1 bits (126), Expect = 4e-07
Identities = 48/197 (24%), Positives = 73/197 (36%), Gaps = 3/197 (1%)
Query: 11 LQNKTIFITGASAGIGQATALEYLD-AANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKV 69
L + +TG+S GIG+A A+ + A + PQ
Sbjct: 8 LAGRVAIVTGSSRGIGRAIAIHLAELGAKIVINYTTRSTEADQVAAEINSSAGTVPQPIA 67
Query: 70 YIGQLDVTETEKIQPFIDNLPEEFKD-IDILINNAGKALGS-DVVGTISSEDIKGMIDTN 127
+ D++E +I+ D + F + IL+N+AG + + E+ + N
Sbjct: 68 VVFLADISEPSQIKSLFDAAEKAFNSPVHILVNSAGILNPNYPTIANTPIEEFDRIFKVN 127
Query: 128 VVALINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKELI 187
+ K G I+ L S P Y ASK AV A + L KEL
Sbjct: 128 TRGSFLCCKEAAKRLKRGGGGRIILLTSSLTEALIPGQGAYTASKAAVEAMVKILAKELK 187
Query: 188 NTGIRVIEIAPGNVETE 204
GI ++PG V TE
Sbjct: 188 GLGITANCVSPGPVATE 204
>At3g26760 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 269
Score = 53.1 bits (126), Expect = 4e-07
Identities = 45/212 (21%), Positives = 89/212 (41%), Gaps = 26/212 (12%)
Query: 10 RLQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKV 69
+L+ K ITG ++GIG+ATA E++ + +
Sbjct: 4 KLEGKVAVITGGASGIGKATAEEFVSQGAQVIIVDIDEEAGHMVATELG--------SAA 55
Query: 70 YIGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKA----------LGSDVVGTISSED 119
+ + DVTE E+I ++ +D+++N+AG + L D + +
Sbjct: 56 HFLRCDVTEEEQIAKAVETAVTRHGKLDVMLNSAGISCSISPPSIADLDMDTYDKVMRLN 115
Query: 120 IKGMIDTNVVALINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFT 179
++G V+ + + +A++P SG I+ L S++G Y SK +
Sbjct: 116 VRG----TVLGIKHAARAMIP----AGSGSILCLSSISGLMGGLGPHAYSISKFTIPGVV 167
Query: 180 QSLRKELINTGIRVIEIAPGNVETEFSLVRYK 211
+++ EL G+R+ I+P + T +L ++
Sbjct: 168 KTVASELCKHGLRINCISPAGIPTPLTLRMFR 199
>YNL202w [R] KOG0725 Reductases with broad range of substrate specificities
Length = 295
Score = 52.8 bits (125), Expect = 5e-07
Identities = 53/191 (27%), Positives = 82/191 (42%), Gaps = 8/191 (4%)
Query: 67 AKVYIGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDT 126
A + I +DV E+++ + E+F ID +I A D +S K ++D
Sbjct: 80 AVLAIANVDVRNFEQVENAVKKTVEKFGKIDFVIAGAAGNFVCDFAN-LSPNAFKSVVDI 138
Query: 127 NVVALINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKEL 186
+++ N +A L K K+ G I+ + + P A+K + A ++L EL
Sbjct: 139 DLLGSFNTAKACLKELK-KSKGSILFVSATFHYYGVPFQGHVGAAKAGIDALAKNLAVEL 197
Query: 187 INTGIRVIEIAPGNVETEFSLVRYKGDADRAKQVYKGTTPLY----ADDIADLIVYATSR 242
GIR IAPG ++ L R G + K + K PL DIA+ VY S
Sbjct: 198 GPLGIRSNCIAPGAIDNTEGLKRLAGKKYKEKALAK--IPLQRLGSTRDIAESTVYIFSP 255
Query: 243 KPNTVIADVLV 253
+ V VLV
Sbjct: 256 AASYVTGTVLV 266
>SPAC922.06 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 258
Score = 52.8 bits (125), Expect = 5e-07
Identities = 58/246 (23%), Positives = 98/246 (39%), Gaps = 20/246 (8%)
Query: 11 LQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKVY 70
++ + + ITGA+ GIG+ + + + Q
Sbjct: 3 VEGRVVLITGAAGGIGKVLCKMFTELGD--------------RVAGIDIVDPSKVQDAAL 48
Query: 71 IGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNVVA 130
Q DV++ ++I+ I+ + + ID+LINNAG A +S E + +
Sbjct: 49 ALQADVSKADQIETAIEKVIQTLGPIDVLINNAGLA-DDTPFEQLSHESWDHDVSLVLRG 107
Query: 131 LINVTQAVLP-IFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKELINT 189
+ V+P + K G IVN+GSV G Y Y A+K + T++L
Sbjct: 108 NYLTQRYVIPHMAKQGKGGSIVNIGSVNGH-IYLGSPAYSAAKAGLENLTKALAVRYGPL 166
Query: 190 GIRVIEIAPGNVETEFSLVRYKGD---ADRAKQVYKGTTPLYADDIADLIVYATSRKPNT 246
GIRV APG + + R+K DR K+ Y +D+A +++ K +
Sbjct: 167 GIRVNVCAPGTIWSPAWDERFKKHPDVGDRMKRWYPVGRLGTPEDVARAVIFLADSKNSF 226
Query: 247 VIADVL 252
+ L
Sbjct: 227 ITGTTL 232
>At3g42960 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 272
Score = 52.8 bits (125), Expect = 5e-07
Identities = 47/204 (23%), Positives = 83/204 (40%), Gaps = 11/204 (5%)
Query: 9 ERLQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAK 68
+RL K ITG + GIG ATA + + NG
Sbjct: 6 KRLFEKVAIITGGARGIGAATARLFTE--NGAYVIVADILENEGILVAESIGG------- 56
Query: 69 VYIGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNV 128
Y+ DV++ ++ ++ +D++ NNAG +L + + + + ++ NV
Sbjct: 57 CYV-HCDVSKEADVEAAVELAMRRKGRLDVMFNNAGMSLNEGSIMGMDVDMVNKLVSVNV 115
Query: 129 VALIN-VTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKELI 187
+++ + A + K G I+ S +G G Y SK A+ ++ EL
Sbjct: 116 NGVLHGIKHAAKAMIKGGRGGSIICTSSSSGLMGGLGGHAYTLSKGAINGVVRTTACELG 175
Query: 188 NTGIRVIEIAPGNVETEFSLVRYK 211
+ GIRV I+P V T+ + Y+
Sbjct: 176 SHGIRVNSISPHGVPTDILVNAYR 199
>At3g03980 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 270
Score = 52.8 bits (125), Expect = 5e-07
Identities = 49/201 (24%), Positives = 74/201 (36%), Gaps = 7/201 (3%)
Query: 11 LQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQA--- 67
L + +TG+S GIG+A A+ + V +
Sbjct: 14 LAGRVAIVTGSSRGIGRAIAIHLAELGARIVINYTSKAADAERVASEINDFPVREEITGK 73
Query: 68 --KVYIGQLDVTETEKIQPFIDNLPEEFK-DIDILINNAGKALGS-DVVGTISSEDIKGM 123
+ + Q +V+E +++ D F+ + IL+N+AG + S ED
Sbjct: 74 GPRAIVVQANVSEPSQVKSMFDAAESAFEAPVHILVNSAGILDPKYPTIADTSVEDFDHT 133
Query: 124 IDTNVVALINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLR 183
N ++ K G I+ L S R P Y ASK AV + L
Sbjct: 134 FSVNTKGAFLCSKEAANRLKQGGGGRIILLTSSQTRSLKPGFGAYAASKAAVETMVKILA 193
Query: 184 KELINTGIRVIEIAPGNVETE 204
KEL TGI +APG + TE
Sbjct: 194 KELKGTGITANCVAPGPIATE 214
>At2g29260 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 322
Score = 52.8 bits (125), Expect = 5e-07
Identities = 36/154 (23%), Positives = 77/154 (49%), Gaps = 4/154 (2%)
Query: 75 DVTETEKIQPFIDNLPEEFKD-IDILINNAGKALGSDVVGTISSEDIKGMIDTNVVALIN 133
DV++ + + ++ + F+ + IL+NN G + +V + E ++ TN ++ +
Sbjct: 127 DVSDRSQREALMETVSSVFEGKLHILVNNVGTNIRKPMVEFTAGE-FSTLMSTNFESVFH 185
Query: 134 VTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKELINTGIRV 193
+ Q P+ + +G +V + SV+G + S+ ++K A+ T+SL E IR+
Sbjct: 186 LCQLAYPLLRESKAGSVVFISSVSGFVSLKNMSVQSSTKGAINQLTRSLACEWAKDNIRI 245
Query: 194 IEIAPGNVETEFSLVRYKGDADRAKQVYKGTTPL 227
+AP ++T + + + + ++VY TPL
Sbjct: 246 NAVAPWYIKTSM-VEQVLSNKEYLEEVY-SVTPL 277
>7290874 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 320
Score = 52.4 bits (124), Expect = 7e-07
Identities = 48/197 (24%), Positives = 82/197 (41%), Gaps = 10/197 (5%)
Query: 11 LQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKVY 70
+ K + ITG G+G+ AL+Y + K +
Sbjct: 56 VNGKVVLITGTGHGMGKEMALQY-----AKLGATILCWDVNEQTNNQTVKEIKNNGGKAF 110
Query: 71 IGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNVVA 130
+VT+ E++ + +E I +++NNAG ++ +E I+ M + NV++
Sbjct: 111 GYVCNVTKREELIELAQKVRKEHGFIHVVVNNAGIMPCHPLLEHTENE-IRLMYEINVLS 169
Query: 131 LINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVR----AFTQSLRKEL 186
+ QA LP +N G IV L S AG YC +K AVR A + LR++
Sbjct: 170 HFWIIQAFLPDMIERNEGSIVALSSCAGLFGLINLVPYCGTKFAVRGYMAALVEELRQKN 229
Query: 187 INTGIRVIEIAPGNVET 203
+++ I P ++T
Sbjct: 230 PQNNVKLTTIYPYMIDT 246
>7300944 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 321
Score = 52.0 bits (123), Expect = 9e-07
Identities = 44/180 (24%), Positives = 74/180 (40%), Gaps = 5/180 (2%)
Query: 7 AAERLQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQ 66
A + + + +TGA G+G+A +LE A G +
Sbjct: 46 APKSIAGEVAVVTGAGHGLGRAISLEL--AKKGCHIAVVDINVSGAEDTVKQIQDIYKVR 103
Query: 67 AKVYIGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDT 126
AK Y + +VT + + + EE + +L+NNAG + ++ D++ MI+
Sbjct: 104 AKAY--KANVTNYDDLVELNSKVVEEMGPVTVLVNNAGVMMHRNMFNP-DPADVQLMINV 160
Query: 127 NVVALINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKEL 186
N+ + LP K G IV + S+AG P + Y +K A ++LR EL
Sbjct: 161 NLTSHFWTKLVFLPKMKELRKGFIVTISSLAGVFPLPYSATYTTTKSGALAHMRTLRMEL 220
>Hs4557649 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 310
Score = 51.6 bits (122), Expect = 1e-06
Identities = 50/201 (24%), Positives = 87/201 (42%), Gaps = 11/201 (5%)
Query: 6 KAAERLQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYP 65
K+ R + ITGA GIG+A + E V
Sbjct: 41 KSFLRSMGQWAVITGAGDGIGKAYSFELAKRGLNVVLISRTLEKLEAIATEIERTTGR-- 98
Query: 66 QAKVYIGQLDVTETEKIQPFIDNLPEEFKDIDILINNAG---KALGSDVVGTISSEDIKG 122
V I Q D T+ + + + L +I IL+NN G L S + + ++I+
Sbjct: 99 --SVKIIQADFTKDDIYEHIKEKLAG--LEIGILVNNVGMLPNLLPSHFLN--APDEIQS 152
Query: 123 MIDTNVVALINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSL 182
+I N+ +++ +TQ +L +++ G I+N+ S +P S+Y ASK V AF+++L
Sbjct: 153 LIHCNITSVVKMTQLILKHMESRQKGLILNISSGIALFPWPLYSMYSASKAFVCAFSKAL 212
Query: 183 RKELINTGIRVIEIAPGNVET 203
++E + + + P V T
Sbjct: 213 QEEYKAKEVIIQVLTPYAVST 233
>Hs19923931 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 260
Score = 51.6 bits (122), Expect = 1e-06
Identities = 43/144 (29%), Positives = 63/144 (42%), Gaps = 16/144 (11%)
Query: 74 LDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNVVALIN 133
LD+ + I+ F + EE + +DILINNAG + + + N +
Sbjct: 25 LDLASLKSIREFAAKIIEEEERVDILINNAGVMRCPHWT---TEDGFEMQFGVNHLGHFL 81
Query: 134 VTQAVLPIFKAKNSGDIVNLGS---VAGR----------DAYPTGSIYCASKHAVRAFTQ 180
+T +L KA I+NL S VAG Y T + YC SK A+ FT+
Sbjct: 82 LTNLLLDKLKASAPSRIINLSSLAHVAGHIDFDDLNWQTRKYNTKAAYCQSKLAIVLFTK 141
Query: 181 SLRKELINTGIRVIEIAPGNVETE 204
L + L +G+ V + PG TE
Sbjct: 142 ELSRRLQGSGVTVNALHPGVARTE 165
>CE06316 [Q] KOG1207 Diacetyl reductase/L-xylulose reductase
Length = 251
Score = 51.6 bits (122), Expect = 1e-06
Identities = 44/151 (29%), Positives = 68/151 (44%), Gaps = 8/151 (5%)
Query: 71 IGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNVVA 130
+G + E + + + P I L+NNAG A + +G I+ + I NV
Sbjct: 64 VGDVSANEEVLFKLIVPHFP-----IHGLVNNAGIAT-NHAIGQITQQSIDRTFAVNVRG 117
Query: 131 LINVTQAVLPIFKAKN-SGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKELINT 189
I + Q V F + G IVN+ S A ++YCASK A+ T+ L EL +
Sbjct: 118 PILIAQLVARNFVDRQIKGSIVNISSQAAIRPLDNHTVYCASKAALDMVTRCLANELGSQ 177
Query: 190 GIRVIEIAPGNVETEFSLVRYKGDADRAKQV 220
IRV + P V T+ + D D+ K++
Sbjct: 178 NIRVNSVNPTVVMTDMGRDNW-SDPDKKKKM 207
>CE15790 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 315
Score = 51.2 bits (121), Expect = 1e-06
Identities = 52/197 (26%), Positives = 82/197 (41%), Gaps = 16/197 (8%)
Query: 18 ITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKVYIGQLD-- 75
+TGA+ GIG++ + E A P +V D
Sbjct: 52 VTGATDGIGKSYSFEL---ARRGFNVYIVSRTQSKLEQTKKDILEKQPDIEVRFATYDFT 108
Query: 76 ---VTETEKIQPFIDNLPEEFKDIDILINNAGKALG-SDVVGTISS--EDIKGMIDTNVV 129
VT+ EK+ ++ + + ILINN G +++ I+ + I +I N +
Sbjct: 109 NPSVTDYEKLLSKLNEV-----SVGILINNVGMFFDYPEMLHKINGGIDSIANVIIINTL 163
Query: 130 ALINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKELINT 189
++ +LP ++ +G IVN+GS AG SIY A+K V T LRKE +
Sbjct: 164 PATLLSAGILPQMVSRKAGIIVNIGSFAGVVKLAEWSIYSATKKYVEWLTGCLRKEYSHH 223
Query: 190 GIRVIEIAPGNVETEFS 206
GI I P V T+ +
Sbjct: 224 GIIFQAITPAMVATKMA 240
>At1g07450 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 260
Score = 51.2 bits (121), Expect = 1e-06
Identities = 37/129 (28%), Positives = 65/129 (49%), Gaps = 3/129 (2%)
Query: 96 IDILINNAGKALGSDVVGTISSEDIKGMIDTNVVALINVTQAVLPIFKAKNSGDIVNLGS 155
++ILINN GK + + + ++ED ++ TN+ + ++Q P+ KA +G+IV + S
Sbjct: 89 LNILINNVGKYILKPTLES-TAEDFSSLMATNLESAYYISQLAHPLLKASGNGNIVFISS 147
Query: 156 VAGRDAYPTGSIYCASKHAVRAFTQSLRKELINTGIRVIEIAPGNVETEFSLVRYKGDAD 215
V G T +IY +K A+ + L E + IR +AP T + +Y D
Sbjct: 148 VTG-VVSGTSTIYGVTKGALNQLARDLACEWASDNIRANSVAPWVTATSL-VQKYLEDEI 205
Query: 216 RAKQVYKGT 224
A+ ++ T
Sbjct: 206 FAEAMFSRT 214
>7290912 [R] KOG1611 Predicted short chain-type dehydrogenase
Length = 247
Score = 51.2 bits (121), Expect = 1e-06
Identities = 39/154 (25%), Positives = 73/154 (47%), Gaps = 16/154 (10%)
Query: 67 AKVYIGQLDVTETEKIQPFIDNLPEEFKD--IDILINNAGKALGSDVVGTISSEDIKGMI 124
+ ++I ++D+ + + ++ KD +++L NNAG A S + + S+++ +
Sbjct: 52 SNIHILEIDLRNFDAYDKLVADIEGVTKDQGLNVLFNNAGIAPKSARITAVRSQELLDTL 111
Query: 125 DTNVVALINVTQAVLPIFKAKNSGD-----------IVNLGSVAGR-DAYPTGSIYC--A 170
TN V I + +A LP+ K + I+N+ S+ G G +Y
Sbjct: 112 QTNTVVPIMLAKACLPLLKKAAKANESQPMGVGRAAIINMSSILGSIQGNTDGGMYAYRT 171
Query: 171 SKHAVRAFTQSLRKELINTGIRVIEIAPGNVETE 204
SK A+ A T+SL +L I + + PG V+T+
Sbjct: 172 SKSALNAATKSLSVDLYPQRIMCVSLHPGWVKTD 205
>SPCC663.09c [R] KOG1611 Predicted short chain-type dehydrogenase
Length = 253
Score = 50.8 bits (120), Expect = 2e-06
Identities = 56/238 (23%), Positives = 91/238 (37%), Gaps = 11/238 (4%)
Query: 13 NKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKVYIG 72
NK FI G + GIG + E L + G +P K
Sbjct: 5 NKVYFIAGGNRGIGLSLVKE-LSSREG--TTVFASARKPEAATELQEWSKSHPNVKTV-- 59
Query: 73 QLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNVVALI 132
+LDVT + ++ + ID+L N+G V E TNV+ I
Sbjct: 60 ELDVTSQQSANEAAQSVAKAVDGIDVLWLNSGICQSYYTVMEAPEEVWNAHYQTNVLGPI 119
Query: 133 NVTQAVLPIFKAKNSGDIVNLGSVAGR--DAYPTG-SIYCASKHAVRAFTQSLRKELINT 189
+V +A P+ K + ++ S G D TG S Y SK A+ + L EL +
Sbjct: 120 HVFKAFYPLLTKKKTRQVIFTSSECGSMGDFRATGFSAYGQSKAAINFTMKELSVELADE 179
Query: 190 GIRVIEIAPGNVETEFSLVRYKGDADRAKQV---YKGTTPLYADDIADLIVYATSRKP 244
I I PG V+T+ + K + + ++ K T + + ++ ++ + KP
Sbjct: 180 HFTFISIHPGVVKTDMNADAIKKFTETSPEMLTYLKKVTIIPEESVSSMLKVVDNLKP 237
>At3g29260 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 259
Score = 50.4 bits (119), Expect = 3e-06
Identities = 60/244 (24%), Positives = 93/244 (37%), Gaps = 20/244 (8%)
Query: 7 AAERLQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQ 66
+ +RL K + ITG ++GIG A + D V
Sbjct: 2 SGQRLDGKIVIITGGASGIGAEAARLFTDHGAKVVIVDLQEELGQNVAVSIGLD------ 55
Query: 67 AKVYIGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDT 126
K + D+T+ +++ + E+ +D+L +NAG + G+I D++ T
Sbjct: 56 -KASFYRCDITDETEVENAVKFTVEKHGKLDVLFSNAGV---MEPHGSILDLDLEAFDRT 111
Query: 127 NVV----ALINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSL 182
V A + A + + G IV SV P Y ASKHA+ +S
Sbjct: 112 MAVNVRGAAAFIKHAARSMVASGTRGSIVCTTSVTAEIGGPGPHSYTASKHALLGLVRSA 171
Query: 183 RKELINTGIRVIEIAPGNVETEFS-----LVRYKGDADRAKQVYKGTTPLYADDIADLIV 237
L GIRV +AP V T + V+ D A + KG L A +AD +
Sbjct: 172 CGGLGKYGIRVNGVAPYGVATGLTSYNEETVKMVEDYCSATAILKGVV-LKARHVADAAL 230
Query: 238 YATS 241
+ S
Sbjct: 231 FLAS 234
>SPCC663.08c [R] KOG1611 Predicted short chain-type dehydrogenase
Length = 253
Score = 50.1 bits (118), Expect = 3e-06
Identities = 57/197 (28%), Positives = 82/197 (40%), Gaps = 12/197 (6%)
Query: 13 NKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKVYIG 72
NK FI G + GIG + E L G V + V+I
Sbjct: 5 NKIYFIAGGNRGIGLSLVKE-LSNRKGTVVFASARKPGAATKLQEWSKS----HSNVHII 59
Query: 73 QLDVTETEKIQPFIDNLPEEFKDIDIL-INNAGKALGSDVVGTISSEDI-KGMIDTNVVA 130
+LDV+ E + + +D+L +N+A VV T +D+ TNV+
Sbjct: 60 KLDVSSLESANEAAQEVTKVVDAVDVLWVNSAVFHSFGPVVNT--PDDVWNSHYKTNVLG 117
Query: 131 LINVTQAVLPIFKAKNSGDIVNLGSVAGRDA--YPTG-SIYCASKHAVRAFTQSLRKELI 187
I+V QA P+ K S IV S+AG +P+ S Y SK A+ + + EL
Sbjct: 118 PIHVYQAFYPLIKKGRSKIIVFTSSLAGSMGAFFPSSQSAYGQSKAALNYTMKEISFELQ 177
Query: 188 NTGIRVIEIAPGNVETE 204
+ G VI I PG V T+
Sbjct: 178 DEGFIVISIHPGAVRTD 194
>Hs22050208 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 341
Score = 50.1 bits (118), Expect = 3e-06
Identities = 41/139 (29%), Positives = 63/139 (44%), Gaps = 4/139 (2%)
Query: 68 KVYIGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTN 127
+V+ DV + E + + + +E ++ +L+NNAG G ++ E I+ + N
Sbjct: 111 QVFTYTCDVGKRENVYLTAERVRKEVGEVSVLVNNAGVVSGHHLL-ECPDELIERTMMVN 169
Query: 128 VVALINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKEL- 186
A T+A LP N G IV + S G + YCASK V F +SL EL
Sbjct: 170 CHAHFWTTKAFLPTMLEINHGHIVTVASSLGLFSTAGVEDYCASKFGVVGFHESLSHELK 229
Query: 187 --INTGIRVIEIAPGNVET 203
GI+ + P V+T
Sbjct: 230 AAEKDGIKTTLVCPYLVDT 248
>CE07961 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 314
Score = 50.1 bits (118), Expect = 3e-06
Identities = 50/194 (25%), Positives = 78/194 (39%), Gaps = 10/194 (5%)
Query: 18 ITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKVYIGQLDVT 77
+TGA+ GIG++ + E A +P +V D T
Sbjct: 52 VTGATDGIGKSYSFEL---AKRGFNVYIVSRTQSKLEHTKKEILEVHPDIEVRFATFDFT 108
Query: 78 E--TEKIQPFIDNLPEEFKDIDILINNAGKALG-SDVVGTISS--EDIKGMIDTNVVALI 132
+ + L E I ILINN G +++ I+ + I + N +
Sbjct: 109 NPSVSDYEKLLSKLNEV--SIGILINNVGMFFDYPEMLHKINGGIDSIANVTIINTLPAT 166
Query: 133 NVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKELINTGIR 192
++ +LP + +G IVN+GSVAG S+Y A+K V T L+KE + GI
Sbjct: 167 LLSAGILPQMVPRKAGIIVNIGSVAGLATMAEWSVYSATKKYVEWITGCLQKEYGHQGII 226
Query: 193 VIEIAPGNVETEFS 206
I P V T+ +
Sbjct: 227 FQAITPAMVATKMA 240
>7290849 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 321
Score = 50.1 bits (118), Expect = 3e-06
Identities = 31/119 (26%), Positives = 60/119 (50%), Gaps = 4/119 (3%)
Query: 95 DIDILINNAGKALGSD--VVGTISSED--IKGMIDTNVVALINVTQAVLPIFKAKNSGDI 150
++ +L+NN G + G + ++ ++ ++ N+ ++ ++T LP ++ G I
Sbjct: 129 NVGVLVNNVGISYGHPEYFLDCYKADPPFLRNIVAANIHSVTHMTALFLPGMISQRRGVI 188
Query: 151 VNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKELINTGIRVIEIAPGNVETEFSLVR 209
+N+ S AG P S+Y ++K V F+ L+ E GI + + PG V T S +R
Sbjct: 189 INVSSTAGVIPNPLLSVYSSTKAFVNKFSDDLQTEYKEHGILIQSVQPGFVATNMSKIR 247
>CE19130 [I] KOG1200 Mitochondrial/plastidial beta-ketoacyl-ACP reductase
Length = 296
Score = 49.7 bits (117), Expect = 4e-06
Identities = 45/194 (23%), Positives = 84/194 (43%), Gaps = 9/194 (4%)
Query: 11 LQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKVY 70
L +K +TG +GIGQA ++ AA+G P
Sbjct: 54 LSSKLAIVTGGGSGIGQAICKKF--AASG-----ARLIVADLKKSAAEATAGNLPGNGHS 106
Query: 71 IGQLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNVVA 130
++DV++ E + + + + +L+N AG + ++ +S + +++ N+ +
Sbjct: 107 AFEIDVSDPEHVARLQEFIKSSGESPSVLVNCAGITKDATLL-KMSQNQWQDVMNVNLNS 165
Query: 131 LINVTQAVLPIFKAKNSG-DIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKELINT 189
+ ++Q + A S IVN+ S+ G+ + Y A+K V FT+S +EL
Sbjct: 166 VFLMSQMIARESVAAGSPLSIVNVSSIVGKIGNFGQTNYAATKSGVIGFTKSAARELATK 225
Query: 190 GIRVIEIAPGNVET 203
IRV + PG + T
Sbjct: 226 NIRVNAVLPGFIRT 239
>CE10908 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 313
Score = 49.7 bits (117), Expect = 4e-06
Identities = 58/268 (21%), Positives = 102/268 (37%), Gaps = 28/268 (10%)
Query: 11 LQNKTIFITGASAGIGQA--TALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAK 68
L K +TG G+G+A T +L A+ P
Sbjct: 24 LNGKVALVTGGGTGLGKAIATTFAHLGASVAIAARRLDVLEKTADEIRSSTGGVCEPF-- 81
Query: 69 VYIGQLDVTETEKIQPFIDNLPEEFKDI-DILINNAG-------KALGSDVVGTISSEDI 120
Q+DV + K+ D + ++ DILINNA + L + GTI +
Sbjct: 82 ----QMDVKDPAKVAKAFDAVEKKLGHTPDILINNAAGNFIMATERLSPNAYGTIIDIVL 137
Query: 121 KGMIDTNVVALINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQ 180
KG + T+ + K ++++ ++ + P SK V T+
Sbjct: 138 KGTLHVT-------TELGRRCIQQKRGASVLSITTLYAQSGAPFVVPSAVSKAGVENMTK 190
Query: 181 SLRKELINTGIRVIEIAPGNVETEFSLVR-YKGDADRAKQVYKGTTPL----YADDIADL 235
SL E G+R IAPG + TE + R + G+ + K + P+ + ++IA+L
Sbjct: 191 SLASEWAKHGLRFNAIAPGPIPTEGAFGRLFAGELKDSGDAMKASVPVGRLGHPEEIANL 250
Query: 236 IVYATSRKPNTVIADVLVFASNQASPYH 263
+ +S + + ++ F Q +H
Sbjct: 251 AAFMSSDFMSWMNGAIIDFDGGQQHIHH 278
>CE09002 [R] KOG1611 Predicted short chain-type dehydrogenase
Length = 250
Score = 49.7 bits (117), Expect = 4e-06
Identities = 49/210 (23%), Positives = 88/210 (41%), Gaps = 28/210 (13%)
Query: 15 TIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKVYIGQL 74
++ +TGA+ GIG + + N ++V++ L
Sbjct: 5 SVVVTGANRGIGLGLVQQLVKDKN------IRHIIATARDVEKATELKSIKDSRVHVLPL 58
Query: 75 DVTETEKIQPFIDNLPEEFKD--IDILINNAGKALGSDVVGTISSEDIKGMIDTNVVALI 132
VT + + F+ + E + +LINNAG L + I +D N +++
Sbjct: 59 TVTCDKSLDTFVSKVGEIVGSDGLSLLINNAGVLLSYGTNTEPNRAVIAEQLDVNTTSVV 118
Query: 133 NVTQAVLPIFK---AKNSGDIVN------------LGSV----AGRDAYPTGSIYCASKH 173
+TQ +LP+ K +K SGD ++ LGS+ +G +P + Y SK
Sbjct: 119 LLTQKLLPLLKNAASKESGDQLSVSRAAVITISSGLGSITDNTSGSAQFPVLA-YRMSKA 177
Query: 174 AVRAFTQSLRKELINTGIRVIEIAPGNVET 203
A+ F ++L +L + + V+ PG V+T
Sbjct: 178 AINMFGRTLAVDLKDDNVLVVNFCPGWVQT 207
>Hs4502601 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 277
Score = 49.3 bits (116), Expect = 6e-06
Identities = 41/146 (28%), Positives = 64/146 (43%), Gaps = 11/146 (7%)
Query: 13 NKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKVYIG 72
++ +TGA+ GIG A A E +G+V P+
Sbjct: 5 SRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPR----FH 60
Query: 73 QLDVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKG--MIDTNVVA 130
QLD+ + + I+ D L +E+ +++L+NNA A SD DIK + TN A
Sbjct: 61 QLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSD---DPMPFDIKAEMTLKTNFFA 117
Query: 131 LINVTQAVLPIFKAKNSGDIVNLGSV 156
N+ +LPI K G +VN+ S+
Sbjct: 118 TRNMCNELLPIMKP--HGRVVNISSL 141
>CE09001 [R] KOG1611 Predicted short chain-type dehydrogenase
Length = 250
Score = 49.3 bits (116), Expect = 6e-06
Identities = 49/211 (23%), Positives = 88/211 (41%), Gaps = 26/211 (12%)
Query: 14 KTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYPQAKVYIGQ 73
K++ ITGA+ GIG E++ N +V Q
Sbjct: 4 KSVVITGANRGIGLGLVQEFVKDKN------IRHIIATARDVEKATDLKAISDPRVTALQ 57
Query: 74 LDVTETEKIQPFIDNLPE--EFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNVVAL 131
L+VT + + F+ + E +++L+NNAG A+ + ++ N ++
Sbjct: 58 LEVTCDKSMDTFVSKVEEIVGSDGLNLLVNNAGNAVDYPCKAKPNRALFAEQLNVNTTSV 117
Query: 132 INVTQAVLPIF---KAKNSGD--------IVNLGS-VAGRDAYPTGS------IYCASKH 173
+ +TQ ++P+ +K SGD +V + S +A + TG Y SK
Sbjct: 118 VILTQKLMPLLIKASSKVSGDQLSASRAAVVTISSGLASMTDFATGGHAPNAFAYRISKA 177
Query: 174 AVRAFTQSLRKELINTGIRVIEIAPGNVETE 204
A+ F ++L ++ + I V I PG V+T+
Sbjct: 178 AINMFGRALANDMKDDHILVASIGPGWVKTD 208
>YIR035c [Q] KOG1204 Predicted dehydrogenase
Length = 254
Score = 48.9 bits (115), Expect = 7e-06
Identities = 35/133 (26%), Positives = 63/133 (47%), Gaps = 3/133 (2%)
Query: 75 DVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDIKGMIDTNVVALINV 134
D+TE ++ ++ + ID L+ NAG V I K + D N +++++
Sbjct: 58 DITEDSVLKQLVNAAVKGHGKIDSLVANAGVLEPVQNVNEIDVNAWKKLYDINFFSIVSL 117
Query: 135 TQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQSLRKELINTGIRVI 194
LP K K +G++V + S A + + Y +SK A+ F +L E ++ I
Sbjct: 118 VGIALPELK-KTNGNVVFVSSDACNMYFSSWGAYGSSKAALNHFAMTLANE--ERQVKAI 174
Query: 195 EIAPGNVETEFSL 207
+APG V+T+ +
Sbjct: 175 AVAPGIVDTDMQV 187
>At1g24360 [I] KOG1200 Mitochondrial/plastidial beta-ketoacyl-ACP reductase
Length = 308
Score = 48.9 bits (115), Expect = 7e-06
Identities = 56/242 (23%), Positives = 105/242 (43%), Gaps = 34/242 (14%)
Query: 6 KAAERLQNKTIFITGASAGIGQATALEYLDAANGNVXXXXXXXXXXXXXXXXXXXXXXYP 65
+ +++++ + ITGAS GIG+A AL L A V
Sbjct: 69 EVVQKVESPVVVITGASRGIGKAIALA-LGKAGCKVLVNYARSAKEAEEVA--------K 119
Query: 66 QAKVYIGQL-----DVTETEKIQPFIDNLPEEFKDIDILINNAGKALGSDVVGTISSEDI 120
Q + Y GQ DV++ + + +++ ID+++NNAG + ++ S+
Sbjct: 120 QIEEYGGQAITFGGDVSKATDVDAMMKTALDKWGTIDVVVNNAGITRDTLLIRMKQSQ-- 177
Query: 121 KGMIDTNVVALINVTQAVLPIFKAKNSGDIVNLGSVAGRDAYPTGSIYCASKHAVRAFTQ 180
+ V +N+T L G I+N+ SV G + Y A+K V +F++
Sbjct: 178 -----WDEVIALNLTGVFL-----CTQGRIINISSVVGLIGNIGQANYAAAKGGVISFSK 227
Query: 181 SLRKELINTGIRVIEIAPGNVETEFSLVRYKGDADRAKQVYKGTTPL----YADDIADLI 236
+ +E + I V + PG + ++ + + D K++ GT PL A+++A L+
Sbjct: 228 TAAREGASRNINVNVVCPGFIASDMTA---ELGEDMEKKIL-GTIPLGRYGKAEEVAGLV 283
Query: 237 VY 238
+
Sbjct: 284 EF 285
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.316 0.134 0.368
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,943,973
Number of Sequences: 60738
Number of extensions: 484613
Number of successful extensions: 1970
Number of sequences better than 1.0e-05: 184
Number of HSP's better than 0.0 without gapping: 29
Number of HSP's successfully gapped in prelim test: 155
Number of HSP's that attempted gapping in prelim test: 1640
Number of HSP's gapped (non-prelim): 240
length of query: 268
length of database: 30,389,216
effective HSP length: 105
effective length of query: 163
effective length of database: 24,011,726
effective search space: 3913911338
effective search space used: 3913911338
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)