ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactII2215 good K KOG2473 Transcription RNA polymerase III transcription factor (TF)IIIC subunit
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactII2215 779130 780959 610
(610 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YBR123c [K] KOG2473 RNA polymerase III transcription factor (TF)... 650 0.0
SPAC6F12.11c [K] KOG2473 RNA polymerase III transcription factor... 103 6e-22
7298548 [K] KOG2473 RNA polymerase III transcription factor (TF)... 65 3e-10
CE01063 [K] KOG2473 RNA polymerase III transcription factor (TF)... 54 9e-07
Hs6912402 [K] KOG2473 RNA polymerase III transcription factor (T... 51 4e-06
>YBR123c [K] KOG2473 RNA polymerase III transcription factor (TF)IIIC
subunit
Length = 649
Score = 650 bits (1678), Expect = 0.0
Identities = 324/650 (49%), Positives = 438/650 (66%), Gaps = 41/650 (6%)
Query: 1 MPISEGETATASA--GGQDGSKRLVYAREYTLDLPRISSVELPLKVSSAPESVAKAVDMC 58
MP+ E +S D + L+ A E+TLDLPRI S+ELPL VS+ S+ KA+ MC
Sbjct: 1 MPVEEPLATLSSIPDSSADQAPPLI-ADEFTLDLPRIPSLELPLNVSTKHSSIQKAIKMC 59
Query: 59 GGLSSIKNVLQGR----DENGLELHLNPEQDENDTSTFFNEHPIIGRTVPNRDESVLLKI 114
GG+ +K + ++GL+L+LN + D + + ++FNEHP+IG+ VP RDESV+LK+
Sbjct: 60 GGIEKVKEAFKEHGPIESQHGLQLYLNDDTDSDGSKSYFNEHPVIGKRVPFRDESVILKV 119
Query: 115 SLPKGTLAKHNGNLQKAIAAGMEEKKLRVLPVAIINNTIRFREMSDFQVRLDNLPSAKEY 174
++PKGTL+K+N +++ +I + + KLRV PV+I++NTI+FREMSDFQ++LDN+PSA+E+
Sbjct: 120 TMPKGTLSKNNNSVKDSIKSLKDSNKLRVTPVSIVDNTIKFREMSDFQIKLDNVPSAREF 179
Query: 175 NNSFKSLNWDNFKDYVNSIPDYDTKPYENLNTMIVDRSSNIPPFDWQLPPIPRFSMVNIP 234
+SF SL W+NFK +VNS+PD D++P EN+ +I+DRS IP D+QLPP P+ SMV P
Sbjct: 180 KSSFGSLEWNNFKSFVNSVPDNDSQPQENIGNLILDRSVKIPSTDFQLPPPPKLSMVGFP 239
Query: 235 YIYKYRDNPYAKKSDTGESSVKGTYIKNYQQLVYDFNTTTGIPTQPHPDIVKLFEQGKET 294
+YKY+ NP+AKK G + VKGTYIKNYQ V+D + T IP+Q H ++ FE K+T
Sbjct: 240 LLYKYKANPFAKKKKNGVTEVKGTYIKNYQLFVHDLSDKTVIPSQAHEQVLYDFEVAKKT 299
Query: 295 GIYPGTSKDLQFLEKLEQCLDILHALFEKRPIWVKRHIDGIVPLDLHPALKVALSLCSYR 354
+YPGT D +F E LE+CL IL LF +RPIWVKRH+DGIVP +H +K+AL+L SYR
Sbjct: 300 KVYPGTKSDSKFYESLEECLKILRELFARRPIWVKRHLDGIVPKKIHHTMKIALALISYR 359
Query: 355 FTKGPWRNSYIKLGVDPRTSKEYAQYQTEYFKIERKLLQDPVIKKNLPDPPPKDYQSSVP 414
FT GPWRN+YIK G+DPR+S EYAQYQTEYFKIERKLL P++KKN+P PPP ++S P
Sbjct: 360 FTMGPWRNTYIKFGIDPRSSVEYAQYQTEYFKIERKLLSSPIVKKNVPKPPPLVFESDTP 419
Query: 415 GEIDPRFEFDGKRIPWYLMLQINLLIKEPNIAEIYSQTQLLPEVNELTGWFTELDLTKIR 474
G ID RF+FDGKRIPWYLMLQI+LLI EPNIAE++ + L + NELTGWF ELDL KIR
Sbjct: 420 GGIDSRFKFDGKRIPWYLMLQIDLLIGEPNIAEVFHNVEYLDKANELTGWFKELDLVKIR 479
Query: 475 KIVKYELGCMVQGNYEFNEHKLTFFKRMIYVKESMMKD-------------KDAXXXXXX 521
+IVKYELGCMVQGNYE+N++KL +FK M++VKESM+ + KDA
Sbjct: 480 RIVKYELGCMVQGNYEYNKYKLKYFKTMLFVKESMVPENKNSEEGMGVNTNKDADGDINM 539
Query: 522 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX---XXSTIRSELADDEQN------------ 566
+ + +E D +QN
Sbjct: 540 DAGSQMSSNAIEEDKGIAAGDDFDDNGAITEEPDDAALENEEMDTDQNLKVPASIDDDVD 599
Query: 567 ------TEPDTFDIKTASFKEVIDKIAKHDSESAEFLKDHIKGLVNENNL 610
E ++FD+KTASF+++I+KIAK D ++AE +K +KG V+E +L
Sbjct: 600 DVDADEEEQESFDVKTASFQDIINKIAKLDPKTAETMKSELKGFVDEVDL 649
>SPAC6F12.11c [K] KOG2473 RNA polymerase III transcription factor (TF)IIIC
subunit
Length = 456
Score = 103 bits (258), Expect = 6e-22
Identities = 103/434 (23%), Positives = 172/434 (38%), Gaps = 96/434 (22%)
Query: 59 GGLSSIKNVLQGRDENG----LELHLNPEQDENDTSTFFNEHPIIGRTVPNRDESVLLKI 114
GG+ SI+ Q +N LEL+L P+ + HP+ R D V +K
Sbjct: 31 GGVQSIQKACQTSFQNPKQALLELNLRPKDKYH--------HPVQARVQSRNDLLVTIK- 81
Query: 115 SLPKGTLAKHNGNLQKAIAAGMEEKKLRVLPVAIINNTIRFREMSDFQVRLDNLPSAKEY 174
K + ++Q V+ I FR+M+DFQ N P ++
Sbjct: 82 --------KMDNSVQN---------------VSRIRQVFLFRDMADFQYSTQNSPFVQKL 118
Query: 175 NNSFKSLNWDNFKDYVNSIPDYDTKPYENLNTMIVDRSSNIPPFDWQLPPIPRFSMVNIP 234
+++ + L+++ + D P + + +PP P FS ++P
Sbjct: 119 DSTLRVLDYNAINKF-----SIDLTPVQRKHV--------------DMPPPPVFSQTSLP 159
Query: 235 YIYKYRDNPYAKKSDTGESSVKGTYIKNYQQLVYDFNTTTGIPTQPHPDIVKLFEQGKET 294
Y + NP + +K Q V+ T G+ + P KL E K
Sbjct: 160 MSYNFLQNPLVGRVRLPNGKTTIVNLKG-QCRVWIITTNMGVESVPTCRHSKLGEPSKT- 217
Query: 295 GIYPGTSKDLQFLEKLEQCLDILHALFEKRPIWVKRHIDGIVPLDLHPALKVALSLCSYR 354
+++ ++ L LFEKRP+W +R + + LK AL SY
Sbjct: 218 ---------------IQEVIEALKPLFEKRPVWTRRALLNHLDPSYTHYLKFALPYLSYL 262
Query: 355 FTKGPWRNSYIKLGVDPRTSKEYAQYQTEYFKIERKLLQDPVIKKNLPDPPPKDYQSSVP 414
+T GP+R++Y + G DPR A YQ +FK +K N K +
Sbjct: 263 WTSGPFRDTYTRFGYDPRKDSNAAAYQALFFK----------LKLNGKHKGTKTH----- 307
Query: 415 GEIDPRFEFDGKRI-PWYLMLQINLLIKEPNIAEIYSQTQLLPEVNELTGWFTELDLTKI 473
FDGK + P + Q+ ++ +P IA + TQL E + TGW+ K+
Sbjct: 308 -------VFDGKTLFPTNRVYQVCDIV-DPTIAPLLKDTQLRSECHRDTGWYRSGRYYKV 359
Query: 474 RKIVKYELGCMVQG 487
R +++ +L +++G
Sbjct: 360 RDLMREKLFALIEG 373
>7298548 [K] KOG2473 RNA polymerase III transcription factor (TF)IIIC
subunit
Length = 480
Score = 65.1 bits (157), Expect = 3e-10
Identities = 112/480 (23%), Positives = 184/480 (38%), Gaps = 104/480 (21%)
Query: 38 VELPLKVSSAPESVAKAVDMCGGLSSIKNVLQGRDENGLELHLNPEQDENDTSTFFNEHP 97
+E P +V + +A GG+ ++ VL G + L LH +PE N P
Sbjct: 16 IEYPGRVVNPDRMIATL----GGIINVSKVL-GDEVKRLALHFHPENPYNK--------P 62
Query: 98 IIGRTVPNRDESVLLKISLPKGTLAKHNGNLQKAIAAGMEEKKLRVLPVAIINNTIRFRE 157
G VLL I T+ +H + Q+ E +RVL + + F
Sbjct: 63 TFGDCTDKT--GVLLSI-----TVRRHKKDKQRP-----PEYFVRVL--GHCSRSFTFET 108
Query: 158 MSDFQV-------RLDNLPSAKEYNNSFKSLNWDNFKDYVNSIPDYDTKPYENLNTMIVD 210
+ DFQ + DN +A+E + L N D DY + + L
Sbjct: 109 LCDFQYLPLWSTPKSDNANAAQELTYALDQLKPKNTTDL-----DYFKRRHSQLLA---- 159
Query: 211 RSSNIPPFDWQLPPIPRFSMVNIPYIYKYRDNPYAKKSDTGESSVKGTYIKNY--QQLVY 268
LP + F+ V+ Y YR +P S+ G+ V G K+ Q V
Sbjct: 160 -----------LPEL--FTHVDTVYAGTYRIDP----SEDGQHEVLGVQSKSSYDNQGVV 202
Query: 269 DFNTTTGIPTQPHPDIVKLFEQGKETGIYPGTSKDLQFLEKLEQCLDILHALFEKRPIWV 328
FN PTQ +K + ++++ ++ L ++ LF+ PIW
Sbjct: 203 SFNMVDSFPTQADSQNLKRLK--------------VKYVS--DEQLALVKKLFDDCPIWT 246
Query: 329 K---RHIDGIVPLDLHPALKVALSLCSYRFTKGPWRNSYIKLGVDPRTSKEYAQYQTEYF 385
+ ++ G+ + LK ++ F+ GPWR Y++ G DPR YQT F
Sbjct: 247 RIALQYESGLT----NDKLKCITPSLAFYFSNGPWRTLYVRFGYDPRKDFNSRYYQTFDF 302
Query: 386 KIERKL-LQDPVIKK---------NLPDPPPKDYQSSVPGEIDPRFEFDGKRIPWYLMLQ 435
++ L + V K N P P +D S + +ID + FD ++P Q
Sbjct: 303 RLRFSTGLSEFVYAKKFVKQRRAANAPFAPIEDRVSDLVQDIDYPY-FDEHKLP--RSRQ 359
Query: 436 INLLIKEPNIAEIYSQTQLLPE------VNELTGWFTELDLTKIRKIVKYELGCMVQGNY 489
L + + I + +P NE TGW ++R+IV + +++ +Y
Sbjct: 360 CMLRYCDVRMTRIQEMLEKIPTPLTGAVCNERTGWLPPGFDAQVRQIVCASISELLRNHY 419
>CE01063 [K] KOG2473 RNA polymerase III transcription factor (TF)IIIC
subunit
Length = 433
Score = 53.5 bits (127), Expect = 9e-07
Identities = 87/412 (21%), Positives = 153/412 (37%), Gaps = 62/412 (15%)
Query: 89 TSTFFNEHPI-IGRTVPNRDESVLLKISLPKGTLAKHNGNL-QKAIAAGMEEKKLRVLPV 146
+ + FN H + + T N S ++ P+ ++ +L K ++ K++ +
Sbjct: 44 SQSHFNNHSLELSHTPDNPYTSRIMAERKPQDNVSSGTLHLVMKVRRKKIDPTKIKTSFL 103
Query: 147 AIINNTIRFREMSDFQVRLDNLPSAKEYNNSFKSLNWDNFKDYVNSIPDYDTKPYENLNT 206
++N F M DFQ LP K + D F+D + + D L+
Sbjct: 104 GLVNTVYTFDVMCDFQY----LPLKKR-------VGCDTFEDLIPKLIPTDIA--SALSW 150
Query: 207 MIVDRSSNIPPFDWQLPPIPRFSMVNIPYIYKY-RDNPYAKKSDTGESSVKGTYIK-NYQ 264
S P F LPP +FS P R+ + +K+ + G ++ +
Sbjct: 151 WDASESVATPLF---LPPY-QFSRYLTPSTKILGRETDHTEKTKNAQKKGYGQNLRVERK 206
Query: 265 QLVYDFNTTTGIPTQPHPDIVKLFEQGKETGIYPGTSKDLQFLEKLEQCLDILHALFEKR 324
L N P +P + V + F K ++ +L LF++R
Sbjct: 207 ALSVTVNAKEEFPLEPSQEAVD----------------EAMFRCKHDEPHRLLRELFDER 250
Query: 325 PIWVKRHIDGIVPLDLHPALKVALSLCSYRFTKGPWRNSYIKLGVDPRTSKEYAQYQT-- 382
P+W + + +D L+ L ++ GPW + K G DPRT + YQT
Sbjct: 251 PMWTRMGLLYRTRID-DSLLRSILQKYAFYILSGPWGRLWCKFGYDPRTDRNGGLYQTIM 309
Query: 383 ------------EYFKIERKLLQDPVIKKNLPDPPPKDYQSSVPGEIDPRFEFDGKRIPW 430
+ K+ Q ++ +P Y+ PG++ PR R W
Sbjct: 310 VSFRQHGSIPERQRLKVSSDRAQTINHTADVSEPVTYMYE---PGKL-PRI-----RQMW 360
Query: 431 YLMLQINL-LIKEPNIAEIYSQTQLLPEVNELTGWFTELDLTKIRKIVKYEL 481
Y ++ + L +A + + T PE GW L KIR ++K ++
Sbjct: 361 YCVMDVRLPQAMNELVAVVENNTPPTPEEVRDKGWLPNTLLEKIRDLIKEDV 412
>Hs6912402 [K] KOG2473 RNA polymerase III transcription factor (TF)IIIC
subunit
Length = 519
Score = 51.2 bits (121), Expect = 4e-06
Identities = 48/179 (26%), Positives = 76/179 (41%), Gaps = 24/179 (13%)
Query: 218 FDWQLP---PIPRFSMVNIPYIYKYRDNP-----YAKKSDTGESSVKGTYIKNYQQLVYD 269
F +LP P P FS ++ P Y YR Y +GE+ + + + ++
Sbjct: 160 FHQELPLYIPPPIFSRLDAPVDYFYRPETQHREGYNNPPISGENLIGLSRARRPHNAIFV 219
Query: 270 FNTTTGIPTQPHPDIVKLFEQGKETGIYPGTSKDLQFLEKLEQCLDILHALFEKRPIWVK 329
+P QP E +T T+ + +E + L LF+ RPIW +
Sbjct: 220 NFEDEEVPKQP-------LEAAAQTWRRVCTNPVDRKVE------EELRKLFDIRPIWSR 266
Query: 330 RHIDGIVPLDLHP-ALKVALSLCSYRFTKGPWRNSYIKLGVDPRTSKEYAQYQTEYFKI 387
+ + +HP LKV L +Y GPWR+ +I+ G DPR + + YQ F+I
Sbjct: 267 NAVKANI--SVHPDKLKVLLPFIAYYMITGPWRSLWIRFGYDPRKNPDAKIYQVLDFRI 323
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.316 0.136 0.397
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,157,044
Number of Sequences: 60738
Number of extensions: 1689220
Number of successful extensions: 4441
Number of sequences better than 1.0e-05: 5
Number of HSP's better than 0.0 without gapping: 1
Number of HSP's successfully gapped in prelim test: 4
Number of HSP's that attempted gapping in prelim test: 4432
Number of HSP's gapped (non-prelim): 7
length of query: 610
length of database: 30,389,216
effective HSP length: 112
effective length of query: 498
effective length of database: 23,586,560
effective search space: 11746106880
effective search space used: 11746106880
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.5 bits)