ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactII2248 good TU KOG4504 Intracellular trafficking, secretion, and vesicular transport Cation-independent mannose-6-phosphate receptor CI-MPR r_klactII2248 good TU KOG4504 Signal transduction mechanisms Cation-independent mannose-6-phosphate receptor CI-MPR
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= r_klactII2248 791305 790298 -336 
         (336 letters)

Database: KOG eukaryal database 04/03 
           60,738 sequences; 30,389,216 total letters

Searching..................................................done

Color Key for Alignment Scores:   


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

YPR079w [TU] KOG4504 Cation-independent mannose-6-phosphate rece...   275   7e-74
SPBC530.09c [TU] KOG4504 Cation-independent mannose-6-phosphate ...   114   2e-25
Hs4504611 [TU] KOG4504 Cation-independent mannose-6-phosphate re...    53   7e-07

>YPR079w [TU] KOG4504 Cation-independent mannose-6-phosphate receptor CI-MPR
          Length = 381

 Score =  275 bits (703), Expect = 7e-74
 Identities = 154/313 (49%), Positives = 196/313 (62%), Gaps = 32/313 (10%)

Query: 55  EDPFCSVVNPNTGGFIDLSWLSSTPNEEKHDGNKD---RNRKEQSKTRWLVKGWEYNTNF 111
           ED FC+V NP TG +IDLS LSSTPN+ + +G K     N+ E SKT+W V+GW Y+TNF
Sbjct: 59  EDLFCAVTNPVTGSYIDLSQLSSTPNKLR-EGQKQISGNNKHESSKTKWSVRGWGYDTNF 117

Query: 112 TLGICSSSVGSELKDQLKDTTGAYYVDHANSDKLVSIGDFSSTPKFTG----KKLTMTYE 167
           TLGICSS VG     QL + TGA+YVD  N + LVSIGDFS+ P   G    KKLT+ YE
Sbjct: 118 TLGICSSPVGEAESQQLSNLTGAFYVDQLNENNLVSIGDFSTRPALVGGSTAKKLTLKYE 177

Query: 168 GGDTCPNGVDKKSTLINFVCDKEIATKAQISFIGQLHNCSYFFEVRSIHACPISNIGNDI 227
            G  CPNG DKK+TL+NFVCDKEI +KAQIS+IG LHNCSYFFEVRSIHACP SN  N++
Sbjct: 178 NGSMCPNGKDKKATLLNFVCDKEIQSKAQISYIGNLHNCSYFFEVRSIHACPTSNKKNEV 237

Query: 228 NAVGIFASIIAVFLLIEIA-RRVVYELLVVEKRHNGD----SGGTSEVPRWVNTEQEPLW 282
           N +GIF  I A+F L+E A RR +Y  L    +++ +    S   +E P W   E    W
Sbjct: 238 NVLGIFIGIFAIFFLVEFAGRRWIYAKLNRHLKNDDELHDISPSLNEQPHWDLIEDGSRW 297

Query: 283 -----------RRILRSVPWSGLGRKKSNKNLVRLRTRENTGISI--------DMEQQNE 323
                      RR  +S+  S +  + S +  +RLR+  +   S         DME QNE
Sbjct: 298 SKFFNGIIKTTRRFTKSLMRSLVRGRNSRQGGIRLRSSPSASSSSLANREFFRDMEAQNE 357

Query: 324 LLDSLDIEANSME 336
           ++DSLDI +++ E
Sbjct: 358 IIDSLDINSHTTE 370


>SPBC530.09c [TU] KOG4504 Cation-independent mannose-6-phosphate receptor CI-MPR
          Length = 296

 Score =  114 bits (286), Expect = 2e-25
 Identities = 72/239 (30%), Positives = 117/239 (48%), Gaps = 36/239 (15%)

Query: 55  EDPFCSVVNPNTGGFIDLSWLSSTPNEEKHDGNKDRNRKEQSKTRWLVKGWEYNTNFTLG 114
           E+PFC++ +PNTG + DLS L      EK D              + V G+++ TNF++ 
Sbjct: 40  EEPFCALHHPNTGEYFDLSGLIRDNTSEKGD--------------YSVNGYDFGTNFSIN 85

Query: 115 ICSSSVGS------ELKDQLKDTTGAYYVDHANSDKLVSIGDFSSTPKFTGKKLTMTYEG 168
           +C   V +      E     +D+ G ++      D L SIG  +  P F GKKL M  + 
Sbjct: 86  LCHPVVSNLTNYTVEGDVSSEDSIGGFFT--VEDDDLYSIGQAAYKPYFRGKKLIMQLDN 143

Query: 169 GDTCPNGVD-KKSTLINFVCDKEIATKAQ-ISFIGQLHNCSYFFEVRSIHACPISNIGND 226
           G  CP     + STLI+F C+++  T    I+++G L++C++FFE ++IHACP     + 
Sbjct: 144 GSLCPKSNHIRMSTLISFTCNRDPYTAPSVITYVGNLNDCAFFFEWKTIHACPTVKKDST 203

Query: 227 INAVGIFASIIAVFLLIEIARRVVYELLVVEKRHNGDSGGTSEVPRWVNTEQEPLWRRI 285
           +N V +F    A+  L       VY+ +V+  R      G  ++P +       +WR +
Sbjct: 204 LNPVSVFLLFCAIAFLAYFVGGFVYQRVVLNAR------GLRQIPNY------EMWRSL 250


>Hs4504611 [TU] KOG4504 Cation-independent mannose-6-phosphate receptor CI-MPR
          Length = 2491

 Score = 52.8 bits (125), Expect = 7e-07
 Identities = 27/83 (32%), Positives = 43/83 (51%), Gaps = 1/83 (1%)

Query: 144  KLVSIGDFSSTPKFTGKKLTMTYEGGDTCPNGVDKKSTLINFVCDKEIATKAQISFIGQL 203
            K V++G     P++    + + Y  GD CP+G+ KKST I F C  E    ++  FI  +
Sbjct: 1433 KPVNLGRVRDGPQWRDGIIVLKYVDGDLCPDGIRKKSTTIRFTC-SESQVNSRPMFISAV 1491

Query: 204  HNCSYFFEVRSIHACPISNIGND 226
             +C Y F   +  ACP+ +  +D
Sbjct: 1492 EDCEYTFAWPTATACPMKSNEHD 1514


  Database: KOG eukaryal database 04/03
    Posted date:  Apr 14, 2003  1:07 PM
  Number of letters in database: 30,389,216
  Number of sequences in database:  60,738
  
Lambda     K      H
   0.315    0.133    0.392 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,495,251
Number of Sequences: 60738
Number of extensions: 833563
Number of successful extensions: 2049
Number of sequences better than 1.0e-05: 3
Number of HSP's better than  0.0 without gapping: 2
Number of HSP's successfully gapped in prelim test: 1
Number of HSP's that attempted gapping in prelim test: 2031
Number of HSP's gapped (non-prelim): 11
length of query: 336
length of database: 30,389,216
effective HSP length: 107
effective length of query: 229
effective length of database: 23,890,250
effective search space: 5470867250
effective search space used: 5470867250
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)