ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactII2286 good T KOG3217 Signal transduction mechanisms Protein tyrosine phosphatase
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactII2286 802641 803111 157
(157 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YPR073c [T] KOG3217 Protein tyrosine phosphatase 207 5e-54
Hs4757714 [T] KOG3217 Protein tyrosine phosphatase 138 3e-33
Hs6005988 [T] KOG3217 Protein tyrosine phosphatase 128 3e-30
At3g44620 [T] KOG3217 Protein tyrosine phosphatase 107 9e-24
7299802 [T] KOG3217 Protein tyrosine phosphatase 98 5e-21
SPAC1071.12c [T] KOG3217 Protein tyrosine phosphatase 88 5e-18
CE27554_1 [T] KOG3217 Protein tyrosine phosphatase 85 4e-17
7300444 [T] KOG3217 Protein tyrosine phosphatase 63 1e-10
>YPR073c [T] KOG3217 Protein tyrosine phosphatase
Length = 161
Score = 207 bits (527), Expect = 5e-54
Identities = 93/154 (60%), Positives = 125/154 (80%), Gaps = 1/154 (0%)
Query: 4 QVSVAFVCLGNICRSPMAEAVFKHVVKEKGLQDKFKRIESFGTAGYHVGESPDSRSASTC 63
++SVAF+CLGN CRSPMAEA+FKH V++ L+++F +I+SFGT+ YHVGESPD R+ S C
Sbjct: 7 KISVAFICLGNFCRSPMAEAIFKHEVEKANLENRFNKIDSFGTSNYHVGESPDHRTVSIC 66
Query: 64 RKNGVPISHSAQQIKSKHFKEFDYIICMDESNLRNLKRIQPKEPKAQLSLFGKWNT-DNK 122
+++GV I+H +QIK+KHF E+DYII MDESN+ NLK+IQP+ KA++ LFG WNT D
Sbjct: 67 KQHGVKINHKGKQIKTKHFDEYDYIIGMDESNINNLKKIQPEGSKAKVCLFGDWNTNDGT 126
Query: 123 FQDIVDDPYYGGNEGFEYNFKQVWYFSEQFLELE 156
Q I++DP+YG + FEYNFKQ+ YFS+QFL+ E
Sbjct: 127 VQTIIEDPWYGDIQDFEYNFKQITYFSKQFLKKE 160
>Hs4757714 [T] KOG3217 Protein tyrosine phosphatase
Length = 158
Score = 138 bits (347), Expect = 3e-33
Identities = 74/158 (46%), Positives = 105/158 (65%), Gaps = 7/158 (4%)
Query: 1 MSEQV--SVAFVCLGNICRSPMAEAVFKHVVKEKGLQDKFKRIESFGTAGYHVGESPDSR 58
M+EQ SV FVCLGNICRSP+AEAVF+ +V ++ + + + R++S T+GY +G PD R
Sbjct: 1 MAEQATKSVLFVCLGNICRSPIAEAVFRKLVTDQNISENW-RVDSAATSGYEIGNPPDYR 59
Query: 59 SASTCRKNGVPISHSAQQIKSKHFKEFDYIICMDESNLRNLKR--IQPKEPKAQLSLFGK 116
S +++G+P+SH A+QI + F FDYI+CMDESNLR+L R Q K KA++ L G
Sbjct: 60 GQSCMKRHGIPMSHVARQITKEDFATFDYILCMDESNLRDLNRKSNQVKTCKAKIELLGS 119
Query: 117 WNTDNKFQDIVDDPYYGGNEGFEYNFKQVWYFSEQFLE 154
+ D + Q I++DPYYG + FE ++Q FLE
Sbjct: 120 Y--DPQKQLIIEDPYYGNDSDFETVYQQCVRCCRAFLE 155
>Hs6005988 [T] KOG3217 Protein tyrosine phosphatase
Length = 158
Score = 128 bits (322), Expect = 3e-30
Identities = 72/158 (45%), Positives = 102/158 (63%), Gaps = 7/158 (4%)
Query: 1 MSEQV--SVAFVCLGNICRSPMAEAVFKHVVKEKGLQDKFKRIESFGTAGYHVGESPDSR 58
M+EQ SV FVCLGNICRSP+AEAVF+ +V ++ + + + I+S + ++VG SPD R
Sbjct: 1 MAEQATKSVLFVCLGNICRSPIAEAVFRKLVTDQNISENWV-IDSGAVSDWNVGRSPDPR 59
Query: 59 SASTCRKNGVPISHSAQQIKSKHFKEFDYIICMDESNLRNLKR--IQPKEPKAQLSLFGK 116
+ S R +G+ +H A+QI + F FDYI+CMDESNLR+L R Q K KA++ L G
Sbjct: 60 AVSCLRNHGIHTAHKARQITKEDFATFDYILCMDESNLRDLNRKSNQVKTCKAKIELLGS 119
Query: 117 WNTDNKFQDIVDDPYYGGNEGFEYNFKQVWYFSEQFLE 154
+ D + Q I++DPYYG + FE ++Q FLE
Sbjct: 120 Y--DPQKQLIIEDPYYGNDSDFETVYQQCVRCCRAFLE 155
>At3g44620 [T] KOG3217 Protein tyrosine phosphatase
Length = 177
Score = 107 bits (266), Expect = 9e-24
Identities = 62/147 (42%), Positives = 83/147 (56%), Gaps = 19/147 (12%)
Query: 6 SVAFVCLGNICRSPMAEAVFKHVVKEKGLQDKFKRIESFGTAGYHVGESPDSRSASTCRK 65
SV FVCLGNICRSP AE VF+ +VK++GL KF I+S GT YH G D R S ++
Sbjct: 16 SVLFVCLGNICRSPAAEGVFRDIVKKRGLDSKF-NIDSAGTIDYHEGNMADPRMRSAAKR 74
Query: 66 NGVPISHSAQQIKSKHFKEFDYIICMDESNLRNLKRI-------------QPKEPKAQLS 112
G+ I+ ++ IK+ F+EFD I+ MD+ N ++ + K+ K S
Sbjct: 75 RGIEITSLSRPIKASDFREFDLILAMDDQNKEDILKAYNVWKARGNFPPDADKKVKLMCS 134
Query: 113 LFGKWNTDNKFQDIVDDPYYGGNEGFE 139
K N +KF V DPYYGG +GFE
Sbjct: 135 YCKKHN--DKF---VPDPYYGGAQGFE 156
>7299802 [T] KOG3217 Protein tyrosine phosphatase
Length = 424
Score = 97.8 bits (242), Expect = 5e-21
Identities = 48/132 (36%), Positives = 79/132 (59%), Gaps = 6/132 (4%)
Query: 4 QVSVAFVCLGNICRSPMAEAVFKHVVKEKGLQDKFKRIESFGTAGYHVGESPDSRSASTC 63
++ V FVC+GN CRSPMAEA+ KH+V ++ LQD + ++S G ++VG P +R
Sbjct: 294 KMKVLFVCIGNTCRSPMAEAILKHLVVKRNLQDWY--VDSAGLRSWNVGLEPQARGQQLL 351
Query: 64 RKNGVPISHSAQQIKSKHFKEFDYIICMDESNLRNLKRIQPK---EPKAQLSLFGKWNTD 120
+++G+ +H + I ++ F +FDYI MD SNL L+ + P ++ L G +
Sbjct: 352 KQHGLKTNHLGRMISAQDFYDFDYIFAMDNSNLLELEHMAASLTPSPTCKIQLLGSY-IG 410
Query: 121 NKFQDIVDDPYY 132
K +I++DPY+
Sbjct: 411 RKEDEIIEDPYF 422
Score = 89.7 bits (221), Expect = 1e-18
Identities = 46/111 (41%), Positives = 68/111 (60%), Gaps = 2/111 (1%)
Query: 41 IESFGTAGYHVGESPDSRSASTCRKNGVPISHSAQQIKSKHFKEFDYIICMDESNLRNLK 100
++S G+HVG D R+ ST +K+G+ +H +QI+ + F EFDYI MDE N+ L+
Sbjct: 178 VDSAAIGGWHVGNRADPRAISTLQKHGLKCTHIVRQIRKQDFSEFDYIFGMDEDNMSELR 237
Query: 101 RIQPKEPKAQLSLFGKWNTDNKFQDIVDDPYY-GGNEGFEYNFKQVWYFSE 150
R+ PK KA+L + G + + K I++DPYY G EGFE ++Q SE
Sbjct: 238 RLAPKGSKAELLMLGDFGLEKK-NRIIEDPYYERGAEGFETAYQQCRCSSE 287
Score = 89.4 bits (220), Expect = 2e-18
Identities = 46/120 (38%), Positives = 71/120 (58%), Gaps = 2/120 (1%)
Query: 13 GNICRSPMAEAVFKHVVKEKGLQDKFKRIESFGTAGYHVGESPDSRSASTCRKNGVPISH 72
GN+CRSP+AEAV + +V GLQ ++ +ES G +H G PD R+ + ++ + +
Sbjct: 44 GNLCRSPIAEAVMRDLVARAGLQGEW-HVESAGIEDWHSGHQPDERALNVLARHNIEYNG 102
Query: 73 SAQQIKSKHFKEFDYIICMDESNLRNLKRIQPKEPKAQLSLFGKWNTDNKFQDIVDDPYY 132
A+ + + F EFDYI MD SNL L+R+ PK A+L + G + + I++DPYY
Sbjct: 103 KARVLAPEDFLEFDYIFAMDLSNLAALRRMAPKGTTAKLLILGNFGL-KPDERIIEDPYY 161
>SPAC1071.12c [T] KOG3217 Protein tyrosine phosphatase
Length = 99
Score = 87.8 bits (216), Expect = 5e-18
Identities = 41/97 (42%), Positives = 64/97 (65%), Gaps = 1/97 (1%)
Query: 58 RSASTCRKNGVPISHSAQQIKSKHFKEFDYIICMDESNLRNLKRIQPKEPKAQLSLFGKW 117
R+ +KNG+ H A+++ + FK FDYI MD SNLRN+ R++P+ +A++ LFG++
Sbjct: 1 RTLEVLKKNGIHTKHLARKLSTSDFKNFDYIFAMDSSNLRNINRVKPQGSRAKVMLFGEY 60
Query: 118 NTDNKFQDIVDDPYYGGNEGFEYNFKQVWYFSEQFLE 154
+ IVDDPYYGG++GF + Q+ FS+ FL+
Sbjct: 61 ASPG-VSKIVDDPYYGGSDGFGDCYIQLVDFSQNFLK 96
>CE27554_1 [T] KOG3217 Protein tyrosine phosphatase
Length = 185
Score = 85.1 bits (209), Expect = 4e-17
Identities = 46/132 (34%), Positives = 77/132 (57%), Gaps = 6/132 (4%)
Query: 13 GNICRSPMAEAVFKHVVKEKGLQDKFKRIESFGTAGYHVGESPDSRSASTCRKNGVP-IS 71
GNICRSP+AEAVF +K++G ++++ ++S GYH G+ PDSR+ +K G+
Sbjct: 40 GNICRSPIAEAVFIDCLKKRGKREEW-HVDSSAIIGYHTGKGPDSRAMGALKKYGIKDYQ 98
Query: 72 HSAQQIKSKHFKEFDYIICMDESNLRNLKRIQPKEP----KAQLSLFGKWNTDNKFQDIV 127
H A+ F++FDYI MD+ N+ +L+ I K P KA++ + G + +++
Sbjct: 99 HRARVTSPDDFRKFDYIFGMDDQNIEDLQEIARKVPKTERKAEILMLGVQDVMAGKREVP 158
Query: 128 DDPYYGGNEGFE 139
D Y G++ F+
Sbjct: 159 DPYYESGSKQFD 170
>7300444 [T] KOG3217 Protein tyrosine phosphatase
Length = 250
Score = 63.2 bits (152), Expect = 1e-10
Identities = 29/93 (31%), Positives = 51/93 (54%), Gaps = 3/93 (3%)
Query: 7 VAFVCLGNICRSPMAEAVFKHVVKEKGLQDKFKRIESFGTAGYHVGESPDSRSASTCRKN 66
+ FVC+GN C SPMAE + ++++ + L + ++S G ++ G P+ R R++
Sbjct: 6 ILFVCMGNSCSSPMAEVIMQNLMVKTSL---YWEVDSAGLRTWNTGRRPNKRCLQILREH 62
Query: 67 GVPISHSAQQIKSKHFKEFDYIICMDESNLRNL 99
G+ H +Q F FDY++ MDE+ + L
Sbjct: 63 GLRSDHFCRQFTVNDFLYFDYVVAMDEAVFKEL 95
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.318 0.135 0.405
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,346,318
Number of Sequences: 60738
Number of extensions: 437434
Number of successful extensions: 1013
Number of sequences better than 1.0e-05: 8
Number of HSP's better than 0.0 without gapping: 6
Number of HSP's successfully gapped in prelim test: 2
Number of HSP's that attempted gapping in prelim test: 992
Number of HSP's gapped (non-prelim): 10
length of query: 157
length of database: 30,389,216
effective HSP length: 97
effective length of query: 60
effective length of database: 24,497,630
effective search space: 1469857800
effective search space used: 1469857800
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)