ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactII2458 check: MH I KOG1014 Lipid transport and metabolism 17 beta-hydroxysteroid dehydrogenase type 3, HSD17B3
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactII2458 857839 856802 -346
(346 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YBR159w [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 ... 426 e-119
SPAC4G9.15 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type... 246 5e-65
7290849 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 ... 156 4e-38
Hs7705855 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type ... 150 2e-36
7298352 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 ... 147 2e-35
Hs19923850 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type... 147 3e-35
CE01875 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 ... 140 3e-33
Hs4557649 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type ... 131 2e-30
CE15790 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 ... 121 2e-27
CE09641 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 ... 119 5e-27
CE07962 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 ... 118 1e-26
7298353 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 ... 115 7e-26
CE07961 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 ... 113 4e-25
CE28036 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 ... 85 2e-16
ECU08g1150 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type... 74 3e-13
YMR226c [Q] KOG1205 Predicted dehydrogenase 72 2e-12
At3g03330 [Q] KOG1205 Predicted dehydrogenase 69 8e-12
Hs4503817 [Q] KOG1210 Predicted 3-ketosphinganine reductase 67 5e-11
7293522 [Q] KOG1207 Diacetyl reductase/L-xylulose reductase 67 5e-11
7300944 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 66 9e-11
Hs7706318 [Q] KOG1205 Predicted dehydrogenase 65 1e-10
7290108 [R] KOG0725 Reductases with broad range of substrate spe... 65 1e-10
At3g47360 [Q] KOG1205 Predicted dehydrogenase 64 2e-10
At3g47350 [Q] KOG1205 Predicted dehydrogenase 64 2e-10
CE27259 [R] KOG0725 Reductases with broad range of substrate spe... 64 4e-10
SPAC521.03 [Q] KOG1205 Predicted dehydrogenase 63 6e-10
CE07539 [Q] KOG1205 Predicted dehydrogenase 63 6e-10
At3g06060 [Q] KOG1210 Predicted 3-ketosphinganine reductase 62 9e-10
Hs20149619 [Q] KOG1205 Predicted dehydrogenase 62 1e-09
At4g10020 [Q] KOG1205 Predicted dehydrogenase 62 2e-09
Hs4504499 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and ... 61 2e-09
CE07544 [Q] KOG1205 Predicted dehydrogenase 61 2e-09
At2g37540 [Q] KOG1208 Dehydrogenases with different specificitie... 61 2e-09
At2g29370 [R] KOG0725 Reductases with broad range of substrate s... 61 2e-09
CE27260 [R] KOG0725 Reductases with broad range of substrate spe... 61 3e-09
At5g19200 [Q] KOG1210 Predicted 3-ketosphinganine reductase 61 3e-09
7296705 [R] KOG0725 Reductases with broad range of substrate spe... 61 3e-09
7301818 [Q] KOG1205 Predicted dehydrogenase 60 5e-09
At2g29150 [R] KOG0725 Reductases with broad range of substrate s... 60 6e-09
YIL124w [Q] KOG1209 1-Acyl dihydroxyacetone phosphate reductase ... 59 1e-08
At2g29350 [R] KOG0725 Reductases with broad range of substrate s... 59 1e-08
CE06316 [Q] KOG1207 Diacetyl reductase/L-xylulose reductase 58 2e-08
Hs5031765 [Q] KOG1205 Predicted dehydrogenase 58 2e-08
At5g50690 [Q] KOG1205 Predicted dehydrogenase 58 2e-08
At5g50590 [Q] KOG1205 Predicted dehydrogenase 58 2e-08
Hs4504503 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and ... 57 3e-08
CE03954 [R] KOG0725 Reductases with broad range of substrate spe... 57 3e-08
At5g10050 [Q] KOG1209 1-Acyl dihydroxyacetone phosphate reductas... 57 3e-08
At3g55310 [R] KOG0725 Reductases with broad range of substrate s... 57 3e-08
At3g46170 [R] KOG0725 Reductases with broad range of substrate s... 57 4e-08
At1g10310 [R] KOG0725 Reductases with broad range of substrate s... 57 5e-08
7300947 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 57 5e-08
CE03132 [R] KOG0725 Reductases with broad range of substrate spe... 56 7e-08
SPAC3G9.02 [R] KOG0725 Reductases with broad range of substrate ... 56 9e-08
CE05526 [R] KOG0725 Reductases with broad range of substrate spe... 56 9e-08
At4g24050 [Q] KOG1208 Dehydrogenases with different specificitie... 56 9e-08
At2g29290 [R] KOG0725 Reductases with broad range of substrate s... 56 9e-08
7296047 [Q] KOG1205 Predicted dehydrogenase 56 9e-08
At2g29170 [R] KOG0725 Reductases with broad range of substrate s... 55 2e-07
At5g50700 [Q] KOG1205 Predicted dehydrogenase 55 2e-07
At5g50600 [Q] KOG1205 Predicted dehydrogenase 55 2e-07
At5g50130 [Q] KOG1208 Dehydrogenases with different specificitie... 55 2e-07
At5g06060 [R] KOG0725 Reductases with broad range of substrate s... 54 3e-07
7301303 [Q] KOG1210 Predicted 3-ketosphinganine reductase 54 3e-07
SPAC23D3.11 [Q] KOG1209 1-Acyl dihydroxyacetone phosphate reduct... 54 3e-07
At1g64590 [Q] KOG1208 Dehydrogenases with different specificitie... 54 3e-07
Hs20475206 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 54 4e-07
CE15574 [R] KOG0725 Reductases with broad range of substrate spe... 54 4e-07
CE05752 [R] KOG0725 Reductases with broad range of substrate spe... 54 4e-07
7290936 [Q] KOG1204 Predicted dehydrogenase 54 4e-07
SPCC1450.15_1 [Q] KOG1210 Predicted 3-ketosphinganine reductase 54 4e-07
Hs20070272 [Q] KOG1208 Dehydrogenases with different specificiti... 53 6e-07
At1g63380 [R] KOG0725 Reductases with broad range of substrate s... 53 6e-07
7296704 [R] KOG0725 Reductases with broad range of substrate spe... 53 6e-07
CE03925_2 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type ... 53 6e-07
SPAC977.08 [Q] KOG1205 Predicted dehydrogenase 53 7e-07
SPAC1348.09 [Q] KOG1205 Predicted dehydrogenase 53 7e-07
Hs7705905 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 53 7e-07
Hs21553325 [Q] KOG1208 Dehydrogenases with different specificiti... 53 7e-07
CE21095 [R] KOG0725 Reductases with broad range of substrate spe... 53 7e-07
At2g30670 [R] KOG0725 Reductases with broad range of substrate s... 53 7e-07
At1g62610 [R] KOG0725 Reductases with broad range of substrate s... 52 1e-06
CE26900 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 52 1e-06
CE23899 [R] KOG0725 Reductases with broad range of substrate spe... 52 1e-06
7300387 [Q] KOG1208 Dehydrogenases with different specificities ... 52 1e-06
Hs4504501_1 [Q] KOG1205 Predicted dehydrogenase 52 1e-06
CE02490_1 [R] KOG0725 Reductases with broad range of substrate s... 52 1e-06
HsM4506571 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and... 52 2e-06
Hs17455069 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and... 52 2e-06
Hs14735093 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and... 52 2e-06
At5g50770 [Q] KOG1205 Predicted dehydrogenase 52 2e-06
At1g24360 [I] KOG1200 Mitochondrial/plastidial beta-ketoacyl-ACP... 52 2e-06
At2g29360 [R] KOG0725 Reductases with broad range of substrate s... 51 2e-06
Hs21361105 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and... 51 3e-06
CE08067 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and re... 51 3e-06
At4g11410 [Q] KOG1208 Dehydrogenases with different specificitie... 51 3e-06
At4g09750 [Q] KOG1208 Dehydrogenases with different specificitie... 51 3e-06
At1g49670_1 [IR] KOG4169 15-hydroxyprostaglandin dehydrogenase a... 51 3e-06
SPCC162.03 [Q] KOG1205 Predicted dehydrogenase 50 4e-06
Hs5031737 [R] KOG0725 Reductases with broad range of substrate s... 50 4e-06
CE05427 [R] KOG0725 Reductases with broad range of substrate spe... 50 4e-06
At5g15940 [Q] KOG1208 Dehydrogenases with different specificitie... 50 4e-06
CE03951 [R] KOG0725 Reductases with broad range of substrate spe... 50 5e-06
SPCC736.13 [Q] KOG1208 Dehydrogenases with different specificiti... 49 8e-06
CE28291 [Q] KOG1208 Dehydrogenases with different specificities ... 49 8e-06
CE26060 [Q] KOG1210 Predicted 3-ketosphinganine reductase 49 8e-06
CE09002 [R] KOG1611 Predicted short chain-type dehydrogenase 49 8e-06
7290874 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 49 8e-06
>YBR159w [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 347
Score = 426 bits (1094), Expect = e-119
Identities = 211/331 (63%), Positives = 263/331 (78%), Gaps = 4/331 (1%)
Query: 20 LNVAAWIVFGLGISKMVFLTLNFSKMVLDLFVLPGPDFXXXXXXXXXXXVVTGASDGIGK 79
+N W+VFGLG+ K L+L F ++ DLF+LP +F +TGASDGIGK
Sbjct: 17 INGLLWVVFGLGVLKCTTLSLRFLALIFDLFLLPAVNFDKYGAKTGKYCAITGASDGIGK 76
Query: 80 EYAKQLAKRGFNLILISRTESKLVELKKEIETECKIDVKILAIDVSSDSKENYTLIREVA 139
E+A+Q+AKRGFNL+LISRT+SKL L+KE+E + + VKILAID++ D + NY I+E+
Sbjct: 77 EFARQMAKRGFNLVLISRTQSKLEALQKELEDQHHVVVKILAIDIAEDKESNYESIKELC 136
Query: 140 SGLPVTVLINNVGKSHSIPVPFDQTEESELRDIITINNTATLMITQTLLPQL----KASV 195
+ LP+TVL+NNVG+SHSIPVPF +TEE ELR+IITINNTATL+ITQ + P++ KA
Sbjct: 137 AQLPITVLVNNVGQSHSIPVPFLETEEKELRNIITINNTATLLITQIIAPKIVETVKAEN 196
Query: 196 KTLKCRGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSNALAGELSSDSIDVELVLSYLV 255
K RGLILTMGSFGGL+PTP LATYSGSK+FLQ WSN+LAGELS D+IDVEL++SYLV
Sbjct: 197 KKSGTRGLILTMGSFGGLIPTPLLATYSGSKSFLQGWSNSLAGELSKDAIDVELIISYLV 256
Query: 256 TSAMSKIRRSSALIPSPKAFVRSTLNSIGKRCGAQERFATSTPYWSHALYHFIIENTVGV 315
TS+MSKIRRSS +IP+P+ FV+STL S+G+RCG+QER+AT TPYW+HA+Y F+I T GV
Sbjct: 257 TSSMSKIRRSSLMIPNPQQFVKSTLRSVGRRCGSQERYATMTPYWAHAVYQFVITETFGV 316
Query: 316 YSKIANSINYSFHLSIRKRALKKAERQAKKQ 346
YSKI NSINYSFH SIR RALKKA RQ KK+
Sbjct: 317 YSKIVNSINYSFHKSIRIRALKKAARQVKKE 347
>SPAC4G9.15 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 341
Score = 246 bits (627), Expect = 5e-65
Identities = 151/339 (44%), Positives = 201/339 (58%), Gaps = 6/339 (1%)
Query: 11 VTALRECSSLNVAAWIVFGLGISKMVFLTLNFSKMVLDLFVLPGPDFXXXXXXXXXXXVV 70
V A + C V A+ V G+ + + F + F+ V F G VV
Sbjct: 5 VLANKSCCGAVVTAFSVIGIVFTILKFTS--FASFVYKTFFAKGVKLSVYGAKKGYWAVV 62
Query: 71 TGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIETECKIDVKILAIDVSSDSKE 130
TGA+DGIGKEYA QLA GFN++LISRT+ KL L KE+ET K+ + +AID + + E
Sbjct: 63 TGATDGIGKEYATQLAMSGFNVVLISRTQEKLDALAKELETVAKVKTRTIAIDYTKTTAE 122
Query: 131 NYTLIREVASGLPVTVLINNVGKSHSIPVPFDQTEESELRDIITINNTATLMITQTLLP- 189
+ + + G P+TVLINNVG+SH +P F +T E+ DI+ IN TL T+ +L
Sbjct: 123 TFEKLHQDLVGTPITVLINNVGQSHYMPTSFAETTVKEMDDIMHINCFGTLHTTKAVLSI 182
Query: 190 QLKASVKTLK-CRGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSNALAGELSSDSIDVE 248
L+ K K R LILTMGSF GLLP+P+L+TY+GSKAFL +WS +L E+ IDV
Sbjct: 183 MLRERQKNEKGPRCLILTMGSFAGLLPSPYLSTYAGSKAFLSNWSASLGEEVKKQGIDVW 242
Query: 249 LVLSYLVTSAMSKIRRSSALIPSPKAFVRSTLNSIGKRCGAQERFATSTPYWSHALYHFI 308
SYLV SAMSK+RR + IP+PK FVR+ L+SIG + G + S PY SHA+ +
Sbjct: 243 CFNSYLVVSAMSKVRRPTLTIPTPKKFVRAALSSIGLQRGGTNPY-ISQPYPSHAVMSWS 301
Query: 309 IENTVGVYSKIANSINYSFHLSIRKRALKKAER-QAKKQ 346
+E +G S + HLSIRKRAL+K R QA+ Q
Sbjct: 302 LEQLLGSAKGFVVSQVAAMHLSIRKRALRKEARLQAQNQ 340
>7290849 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 321
Score = 156 bits (395), Expect = 4e-38
Identities = 103/279 (36%), Positives = 159/279 (56%), Gaps = 19/279 (6%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIETECKIDVKILAIDVSSDS 128
VVTG++DGIGK YAK+LA+RG L+LISR+ KL + KEI + ++V+++ +D +
Sbjct: 56 VVTGSTDGIGKAYAKELARRGLKLVLISRSLEKLNVVAKEIGDKYGVEVRVIDVDFTGGD 115
Query: 129 KENYTLIREVASGLPVTVLINNVGKSHSIPVPFDQTEESE---LRDIITINNTATLMITQ 185
E Y IRE +GL V VL+NNVG S+ P F +++ LR+I+ N + +T
Sbjct: 116 -EIYDKIREKTTGLNVGVLVNNVGISYGHPEYFLDCYKADPPFLRNIVAANIHSVTHMTA 174
Query: 186 TLLPQLKASVKTLKCRGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSNALAGELSSDSI 245
LP + + + RG+I+ + S G++P P L+ YS +KAF+ +S+ L E I
Sbjct: 175 LFLPGMIS-----QRRGVIINVSSTAGVIPNPLLSVYSSTKAFVNKFSDDLQTEYKEHGI 229
Query: 246 DVELVLSYLVTSAMSKIRRSSALIPSPKAFVRSTLNSIGKRCGAQERFATSTP-YWSHAL 304
++ V V + MSKIR++S PSP+ +VRS L+++G AT T Y HAL
Sbjct: 230 LIQSVQPGFVATNMSKIRKASVFAPSPETYVRSALSTLG--------IATQTAGYLPHAL 281
Query: 305 YHFIIENTVGVY-SKIANSINYSFHLSIRKRALKKAERQ 342
+I T V+ + A +I L RKRAL++ ++
Sbjct: 282 LQLVIHFTEAVFGEQFARNIVMKNILGTRKRALRRLAKE 320
>Hs7705855 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 312
Score = 150 bits (380), Expect = 2e-36
Identities = 92/272 (33%), Positives = 153/272 (55%), Gaps = 17/272 (6%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIETECKIDVKILAIDVSSDS 128
VVTG++DGIGK YA++LAK G ++LISR++ KL ++ EI+ + K++ + +A+D +S+
Sbjct: 54 VVTGSTDGIGKSYAEELAKHGMKVVLISRSKDKLDQVSSEIKEKFKVETRTIAVDFASE- 112
Query: 129 KENYTLIREVASGLPVTVLINNVGKSHSIPVPFDQTEESE--LRDIITINNTATLMITQT 186
+ Y I+ +GL + +L+NNVG S+ P F + + ++ +I IN + +TQ
Sbjct: 113 -DIYDKIKTGLAGLEIGILVNNVGMSYEYPEYFLDVPDLDNVIKKMININILSVCKMTQL 171
Query: 187 LLPQLKASVKTLKCRGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSNALAGELSSDSID 246
+LP + + +G IL + S G+LP P L YS +K F+ +S L E S +
Sbjct: 172 VLPGMVE-----RSKGAILNISSGSGMLPVPLLTIYSATKTFVDFFSQCLHEEYRSKGVF 226
Query: 247 VELVLSYLVTSAMSKIRRSSALIPSPKAFVRSTLNSIGKRCGAQERFATSTPYWSHALYH 306
V+ VL Y V + ++KIR+ + PSP+ FV+S + ++G + + + Y HAL
Sbjct: 227 VQSVLPYFVATKLAKIRKPTLDKPSPETFVKSAIKTVGLQ-------SRTNGYLIHALMG 279
Query: 307 FIIENTVG-VYSKIANSINYSFHLSIRKRALK 337
II N +Y KI ++N S K+ K
Sbjct: 280 SIISNLPSWIYLKIVMNMNKSTRAHYLKKTKK 311
>7298352 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 339
Score = 147 bits (372), Expect = 2e-35
Identities = 88/280 (31%), Positives = 156/280 (55%), Gaps = 20/280 (7%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIETECKIDVKILAIDVSSDS 128
VVTGA+DGIGKEYA++LA++G NL+LISRT+ KL+ + EIE++ K+ K +A D +
Sbjct: 74 VVTGATDGIGKEYARELARQGINLVLISRTKEKLIAVTNEIESQYKVKTKWIAADFAK-G 132
Query: 129 KENYTLIREVASGLPVTVLINNVGKSHSIPVPFDQTEESELRDIITINNTATLMITQTLL 188
+E Y I + +G+ V +L+NNVG + P D E L +++T+N + M+T+ +L
Sbjct: 133 REVYDQIEKELAGIDVGILVNNVGMMYEHPESLDLVSEDLLWNLLTVNMGSVTMLTRKIL 192
Query: 189 PQLKASVKTLKCRGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSNALAGELSSDSIDVE 248
PQ+ + +G I+ +GS L P P + Y+ SK F+ +S AL E++ +I V+
Sbjct: 193 PQMIG-----RRKGAIVNLGSSSELQPLPNMTVYAASKKFVTYFSKALELEVAEHNIHVQ 247
Query: 249 LVLSYLVTSAMS----KIRRSSALIPSPKAFVRSTLNSIGKRCGAQERFATSTPYWSHAL 304
LV+ V + M+ ++ + P+ F RS + ++GK + + +W+H +
Sbjct: 248 LVMPNFVVTKMNAYTDRVMQGGLFFPNAYTFARSAVFTLGKT-------SETNGFWTHGI 300
Query: 305 YHFIIENTVGVYSKIANSINYSFHLSIRKRALKKAERQAK 344
+ I++ I + + +R AL++ +++ K
Sbjct: 301 QYAIMKLAP---LPIRTYLGHQLFKRLRIEALEQKQKKLK 337
>Hs19923850 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 309
Score = 147 bits (370), Expect = 3e-35
Identities = 93/242 (38%), Positives = 136/242 (55%), Gaps = 21/242 (8%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIETECKIDVKILAIDVSSDS 128
VV+GA+DGIGK YA++LA RG N+ILISR E KL + K+I K++ I+ D SS
Sbjct: 50 VVSGATDGIGKAYAEELASRGLNIILISRNEEKLQVVAKDIADTYKVETDIIVADFSS-G 108
Query: 129 KENYTLIREVASGLPVTVLINNVGKSHSIPVPFDQTEESELRDIITINNTATLMITQTLL 188
+E Y IRE V +L+NNVG + P F Q E +L DII +N A ++ +L
Sbjct: 109 REIYLPIREALKDKDVGILVNNVGVFYPYPQYFTQLSEDKLWDIINVNIAAASLMVHVVL 168
Query: 189 PQLKASVKTLKCRGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSNALAGELSSDSIDVE 248
P + K G I+T+ S PTP LA +S SKA+L +S AL E +S I V+
Sbjct: 169 PGMVERKK-----GAIVTISSGSCCKPTPQLAAFSASKAYLDHFSRALQYEYASKGIFVQ 223
Query: 249 LVLSYLVTSAMSK----IRRSSALIPSPKAFVRSTLNSIG--KRCGAQERFATSTPYWSH 302
++ + V ++M+ + R S L+PSPK + ++++G KR +T YWSH
Sbjct: 224 SLIPFYVAASMTAPSNFLHRCSWLVPSPKVYAHHAVSTLGISKR---------TTGYWSH 274
Query: 303 AL 304
++
Sbjct: 275 SI 276
>CE01875 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 333
Score = 140 bits (353), Expect = 3e-33
Identities = 107/348 (30%), Positives = 170/348 (48%), Gaps = 26/348 (7%)
Query: 6 DQLYNVTALRE----CSSLNVAAWIVFGLGISKMVFLTLNFSKMVLDLFVLPGPDFXXXX 61
D L+++ L C V A V ++ + + L +L +VL P
Sbjct: 5 DNLHDIDNLENGNMACQCFLVGAGYV---ALAAVAYRLLTIFSNILGPYVLLSP-IDLKK 60
Query: 62 XXXXXXXVVTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEI-ETECKIDVKIL 120
VVTGA+DGIGK YA +LA+RGFN++L+SRT+SKL E KKEI E I+V+
Sbjct: 61 RAGASWAVVTGATDGIGKAYAFELARRGFNVLLVSRTQSKLDETKKEILEKYSSIEVRTA 120
Query: 121 AIDVSSDSKENYTLIREVASGLPVTVLINNVGKSHSIPVPFDQTEE--SELRDIITINNT 178
A D ++ + Y + + + + VLINNVG S+ P + + L +I TIN
Sbjct: 121 AFDFTNAAPSAYKDLLATLNQVEIGVLINNVGMSYEYPDVLHKVDGGIERLANITTINTL 180
Query: 179 ATLMITQTLLPQLKASVKTLKCRGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSNALAG 238
+++ +LPQ+ A + G+I+ +GS G A YS +K ++ + L
Sbjct: 181 PPTLLSAGILPQMVA-----RKAGVIVNVGSSAGANQMALWAVYSATKKYVSWLTAILRK 235
Query: 239 ELSSDSIDVELVLSYLVTSAMSKIRRSSALIPSPKAFVRSTLNSIGKRCGAQERFATSTP 298
E I V+ + +V + MSK++R+S P F +S LN++G + +T
Sbjct: 236 EYEHQGITVQTIAPMMVATKMSKVKRTSFFTPDGAVFAKSALNTVGNT-------SDTTG 288
Query: 299 YWSHALYHFIIENTVGVYSKIANSINYSFHLSIRKRALKKAERQAKKQ 346
Y +H L +E + + I + I + + R AL+K ER+AK Q
Sbjct: 289 YITHQLQ---LELMDLIPTFIRDKILTNMSVGTRAAALRKKEREAKSQ 333
>Hs4557649 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 310
Score = 131 bits (329), Expect = 2e-30
Identities = 82/241 (34%), Positives = 132/241 (54%), Gaps = 15/241 (6%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIETECKIDVKILAIDVSSDS 128
V+TGA DGIGK Y+ +LAKRG N++LISRT KL + EIE VKI+ D + D
Sbjct: 52 VITGAGDGIGKAYSFELAKRGLNVVLISRTLEKLEAIATEIERTTGRSVKIIQADFTKD- 110
Query: 129 KENYTLIREVASGLPVTVLINNVGKSHSIPVPFDQTEESELRDIITINNTATLMITQTLL 188
+ Y I+E +GL + +L+NNVG ++ E++ +I N T+ + +TQ +L
Sbjct: 111 -DIYEHIKEKLAGLEIGILVNNVGMLPNLLPSHFLNAPDEIQSLIHCNITSVVKMTQLIL 169
Query: 189 PQLKASVKTLKCRGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSNALAGELSSDSIDVE 248
+++ K GLIL + S L P P + YS SKAF+ ++S AL E + + ++
Sbjct: 170 KHMESRQK-----GLILNISSGIALFPWPLYSMYSASKAFVCAFSKALQEEYKAKEVIIQ 224
Query: 249 LVLSYLVTSAMSKIRRSSALIPSPKAFVRSTLNSI---GKRCGAQER-----FATSTPYW 300
++ Y V++AM+K ++ + + FV+ +LN + G+ CG F + P W
Sbjct: 225 VLTPYAVSTAMTKYLNTNVITKTADEFVKESLNYVTIGGETCGCLAHEILAGFLSLIPAW 284
Query: 301 S 301
+
Sbjct: 285 A 285
>CE15790 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 315
Score = 121 bits (303), Expect = 2e-27
Identities = 76/265 (28%), Positives = 137/265 (51%), Gaps = 10/265 (3%)
Query: 25 WIVFGLGISKMVFLTLNFSKMVLDLFVLPG--PDFXXXXXXXXXXXVVTGASDGIGKEYA 82
W G+G + ++++ +F +++L++ V VVTGA+DGIGK Y+
Sbjct: 5 WFATGVGAAVVLYIFYHFIRIILNILVPYAFCQPIDLKKKAGASWAVVTGATDGIGKSYS 64
Query: 83 KQLAKRGFNLILISRTESKLVELKKEI-ETECKIDVKILAIDVSSDSKENYTLIREVASG 141
+LA+RGFN+ ++SRT+SKL + KK+I E + I+V+ D ++ S +Y + +
Sbjct: 65 FELARRGFNVYIVSRTQSKLEQTKKDILEKQPDIEVRFATYDFTNPSVTDYEKLLSKLNE 124
Query: 142 LPVTVLINNVGKSHSIPVPFDQTEE--SELRDIITINNTATLMITQTLLPQLKASVKTLK 199
+ V +LINNVG P + + ++I IN +++ +LPQ+ + +
Sbjct: 125 VSVGILINNVGMFFDYPEMLHKINGGIDSIANVIIINTLPATLLSAGILPQMVS-----R 179
Query: 200 CRGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSNALAGELSSDSIDVELVLSYLVTSAM 259
G+I+ +GSF G++ + YS +K +++ + L E S I + + +V + M
Sbjct: 180 KAGIIVNIGSFAGVVKLAEWSIYSATKKYVEWLTGCLRKEYSHHGIIFQAITPAMVATKM 239
Query: 260 SKIRRSSALIPSPKAFVRSTLNSIG 284
+ +S P F RS LN+IG
Sbjct: 240 AGNPNTSFFCPDSDTFARSALNTIG 264
>CE09641 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 314
Score = 119 bits (299), Expect = 5e-27
Identities = 83/270 (30%), Positives = 143/270 (52%), Gaps = 18/270 (6%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIETE-CKIDVKILAIDVSSD 127
VVTGA+DGIG+ YA LA+RGFN+ LISRT+SKLV+ KK+I + I+V+ D +
Sbjct: 57 VVTGATDGIGRSYALDLARRGFNIFLISRTKSKLVKTKKQILNKYSDIEVRYAICDFTRV 116
Query: 128 SKENYTLIREVASGLPVTVLINNVGKSHSIPVPFDQTEESELRDIITINNTATLMITQTL 187
S E+Y + + + + +LINNVG P + E + + + N L +T +
Sbjct: 117 SYEDYKRLLHSLNEVDIGILINNVGMCFDNPEVLHRV-EGGIDTLTNVINVNILPLTAGI 175
Query: 188 LPQLKASVKTLKCRGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSNALAGELSSDSIDV 247
LPQ+ A + G+I+ +GS G + + YS +K +++ +++ L E ++ I
Sbjct: 176 LPQMMA-----RKSGIIVNIGSAAGSIHMAKWSVYSATKKYIEWFTSILQKEYENEGIIC 230
Query: 248 ELVLSYLVTSAMSKIRRSSALIPSPKAFVRSTLNSIGKRCGAQERFATSTPYWSH----A 303
+ + LV++ M K SS P+ +F +S+LN+IG +++T Y +H
Sbjct: 231 QTITPLLVSTNMIKNPLSSIFCPNSDSFAKSSLNTIGNS-------SSTTGYITHQIQFE 283
Query: 304 LYHFIIENTVGVYSKIANSINYSFHLSIRK 333
L F+ E + ++ K N+ + L ++
Sbjct: 284 LIKFVPEIIIDLFVKNLNNQLLDYQLDKKR 313
>CE07962 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 349
Score = 118 bits (295), Expect = 1e-26
Identities = 77/266 (28%), Positives = 133/266 (49%), Gaps = 12/266 (4%)
Query: 25 WIVFGLGISKMVFLTLNFSKMV---LDLFVLPGPDFXXXXXXXXXXXVVTGASDGIGKEY 81
W G+G ++++ +F KM+ L L+V P V+TG +DGIGK +
Sbjct: 5 WFAIGVGAIVVLYILYHFIKMIWSILGLYVFYQP-IDLKKKAGASWAVITGGTDGIGKSF 63
Query: 82 AKQLAKRGFNLILISRTESKLVELKKEI-ETECKIDVKILAIDVSSDSKENYTLIREVAS 140
+ +LAKRGFN+ ++SRT+SKL + KKEI E ++V+ D ++ S +Y + +
Sbjct: 64 SFELAKRGFNIYIVSRTQSKLEQTKKEIMEKYSNVEVRFATFDFTNPSISDYKKLLSQLN 123
Query: 141 GLPVTVLINNVGKSHSIPVPFDQTEE--SELRDIITINNTATLMITQTLLPQLKASVKTL 198
+ + +LINNVG P +T + ++ +N +++ +LPQ+ S KT
Sbjct: 124 EVSIGMLINNVGMLFEYPENLHKTVGGIDVVANVTILNTLPVTLLSAGILPQM-VSRKT- 181
Query: 199 KCRGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSNALAGELSSDSIDVELVLSYLVTSA 258
G+I+ +GS G + YS SK +++ + L E I ++ + LV +
Sbjct: 182 ---GIIVNIGSVAGAAKMAEWSVYSASKKYVEWLTGCLRKEYEHQGIIIQAITPALVATK 238
Query: 259 MSKIRRSSALIPSPKAFVRSTLNSIG 284
+S +S P F +S LN++G
Sbjct: 239 LSGHTETSLFCPDSATFAKSALNTVG 264
>7298353 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 308
Score = 115 bits (289), Expect = 7e-26
Identities = 78/219 (35%), Positives = 126/219 (56%), Gaps = 12/219 (5%)
Query: 70 VTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEI-ETECKIDVKILAIDVSSDS 128
VTGASDGIGKEYAK+LA++ N++LI+RTE KL + KEI + + KI+ D + S
Sbjct: 54 VTGASDGIGKEYAKELARQNINVVLIARTEEKLQAVAKEIADCGAGVQTKIVIADFTKGS 113
Query: 129 KENYTLIREVASGLPVTVLINNVGKSHSIPVPFDQTEESELRDIITINNTATLMITQTLL 188
+ Y I + + +P+++L+NNVG + P + + E ++II N A +++
Sbjct: 114 -QVYEHIEKETANIPISILVNNVG--IATPKSLLKYNQEETQNIIDTNVVAVSQLSRIFF 170
Query: 189 PQLKASVKTLKCRGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSNALAGELSSDSIDVE 248
++KAS K +G I+ +GS L P P A Y+ SKA+ +S + AL E I V+
Sbjct: 171 QRMKAS----KLKGAIVNVGSGTELQPLPNGAYYAASKAYTRSLTLALYHEAKPYGIHVQ 226
Query: 249 LVL-SYLVTSAMS---KIRRSSALIPSPKAFVRSTLNSI 283
++ +++VT S +I + LIPS A+ +S +N +
Sbjct: 227 MLSPNFVVTKINSYSRQIMKGGLLIPSASAYAKSAVNQL 265
>CE07961 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 314
Score = 113 bits (283), Expect = 4e-25
Identities = 75/266 (28%), Positives = 130/266 (48%), Gaps = 12/266 (4%)
Query: 25 WIVFGLGISKMVFLTLNFSKMVLDL---FVLPGPDFXXXXXXXXXXXVVTGASDGIGKEY 81
W G+G ++++ +F ++ L++ +V P VVTGA+DGIGK Y
Sbjct: 5 WFATGVGAVVVLYILYHFIRITLNILGPYVFCQP-IDLKKKAGASWAVVTGATDGIGKSY 63
Query: 82 AKQLAKRGFNLILISRTESKLVELKKEI-ETECKIDVKILAIDVSSDSKENYTLIREVAS 140
+ +LAKRGFN+ ++SRT+SKL KKEI E I+V+ D ++ S +Y + +
Sbjct: 64 SFELAKRGFNVYIVSRTQSKLEHTKKEILEVHPDIEVRFATFDFTNPSVSDYEKLLSKLN 123
Query: 141 GLPVTVLINNVGKSHSIPVPFDQTEE--SELRDIITINNTATLMITQTLLPQLKASVKTL 198
+ + +LINNVG P + + ++ IN +++ +LPQ+
Sbjct: 124 EVSIGILINNVGMFFDYPEMLHKINGGIDSIANVTIINTLPATLLSAGILPQM-----VP 178
Query: 199 KCRGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSNALAGELSSDSIDVELVLSYLVTSA 258
+ G+I+ +GS GL + YS +K +++ + L E I + + +V +
Sbjct: 179 RKAGIIVNIGSVAGLATMAEWSVYSATKKYVEWITGCLQKEYGHQGIIFQAITPAMVATK 238
Query: 259 MSKIRRSSALIPSPKAFVRSTLNSIG 284
M+ +S P F +S LN+IG
Sbjct: 239 MAGNPNTSFFTPDSDTFAKSALNTIG 264
>CE28036 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 378
Score = 84.7 bits (208), Expect = 2e-16
Identities = 61/218 (27%), Positives = 105/218 (47%), Gaps = 13/218 (5%)
Query: 69 VVTGASDGIGKEYAKQLAKRGF-NLILISRTESKLVELKKEIETE-CKIDVKILAIDVSS 126
VV+G +DGIGK Y +LAKRG +LI R KL +K EIE + +K D S
Sbjct: 92 VVSGGTDGIGKAYTLELAKRGLRKFVLIGRNPKKLDSVKSEIEEKHSDAQIKTFVFDFGS 151
Query: 127 DSKENYTLIREVASGLPVTVLINNVGKSHSIPVPFDQTEESELRDIITINNTATLMITQT 186
+++ +R+ S + V ++N+VG + + + + I+ +N
Sbjct: 152 G---DFSSLRDYISDIDVGFVVNSVGTGRDNLERYGDNPDEDTQ-ILRVNGMGAAEFLSC 207
Query: 187 LLPQLKASVKTLKCRGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSNALAGELSSDSID 246
+LP ++ S G I+ + S G+ P P LA Y +KA + ++ E S +I+
Sbjct: 208 VLPPMEKS-----GGGQIVVLSSSQGVRPIPMLAAYCATKALMTFLCESIDREYS--TIN 260
Query: 247 VELVLSYLVTSAMSKIRRSSALIPSPKAFVRSTLNSIG 284
V+ ++ LV + M+ + S + +P+ F + SIG
Sbjct: 261 VQTLIPALVATKMTYYTKGSTFVVTPENFCHQAVGSIG 298
>ECU08g1150 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 296
Score = 73.9 bits (180), Expect = 3e-13
Identities = 67/247 (27%), Positives = 110/247 (44%), Gaps = 36/247 (14%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIE--TECKIDVKILAIDVSS 126
V+ GA+ IG+ AK+ A++G ++L+ R+ES+L+ L IE TEC + + V
Sbjct: 44 VINGATGKIGRGLAKKFAEKGMKVLLVGRSESRLIRLHAAIERMTECHMHI------VDY 97
Query: 127 DSKENYTLIREVASGLPVTVLINNVGKSHSIPVPFDQTEESELRDIITINNTATLMITQT 186
N + I G +LIN P F E + +I+ +N + +T+
Sbjct: 98 KRSNNLSFIDRYDVG----ILINCASTMEDSPAYF---VEQSIEEIMNVNLVGVMSLTRY 150
Query: 187 LLPQLKASVKTLKC-RGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSNALAGELSSDSI 245
+L V + C G ++ +GS G TP + + SK L++ S++L EL ++
Sbjct: 151 VL------VNMMDCGYGYVINIGSLMGEASTPLYSAFGCSKQALKALSDSLYYELEGYNV 204
Query: 246 DVELVLSYLVTSAMSKI---RRSSALIPSPKAFVRSTLNSIGKRCGAQERFATSTPYWSH 302
+VE Y+ MS + S L PS S L++ G S PY H
Sbjct: 205 NVE----YMGVGDMSSEGCGEKPSLLRPSSDTLAESILSTFGSA-------KMSIPYLPH 253
Query: 303 ALYHFII 309
L + +I
Sbjct: 254 FLMYLLI 260
>YMR226c [Q] KOG1205 Predicted dehydrogenase
Length = 267
Score = 71.6 bits (174), Expect = 2e-12
Identities = 63/204 (30%), Positives = 98/204 (47%), Gaps = 20/204 (9%)
Query: 69 VVTGASDGIGKEYAKQLAKRG---FNLILISRTESKLVELKKEIETEC-KIDVKILAIDV 124
++TGAS GIGK A + + LIL +R KL ELKK I+ E V + +D+
Sbjct: 17 LITGASAGIGKATALEYLEASNGDMKLILAARRLEKLEELKKTIDQEFPNAKVHVAQLDI 76
Query: 125 SSDSKENYTLIREVASGLP-----VTVLINNVGKSHSIPVPFDQTEESELRDIITINNTA 179
+ K I+ LP + +L+NN GK+ Q +++D+ N TA
Sbjct: 77 TQAEK-----IKPFIENLPQEFKDIDILVNNAGKALGSD-RVGQIATEDIQDVFDTNVTA 130
Query: 180 TLMITQTLLPQLKASVKTLKCRGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSNALAGE 239
+ ITQ +LP +A K G I+ +GS G P + Y SK + +++++L E
Sbjct: 131 LINITQAVLPIFQA-----KNSGDIVNLGSIAGRDAYPTGSIYCASKFAVGAFTDSLRKE 185
Query: 240 LSSDSIDVELVLSYLVTSAMSKIR 263
L + I V L+ LV + S +R
Sbjct: 186 LINTKIRVILIAPGLVETEFSLVR 209
>At3g03330 [Q] KOG1205 Predicted dehydrogenase
Length = 345
Score = 69.3 bits (168), Expect = 8e-12
Identities = 53/185 (28%), Positives = 91/185 (48%), Gaps = 10/185 (5%)
Query: 70 VTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIETE-CKIDVKILAIDVSSDS 128
+TGAS GIG+ AKQ A LIL +R +++L +K E++ + DVK+L +D++S
Sbjct: 48 ITGASRGIGEILAKQFASLDAKLILSARNKAELDRVKSELKGKFAPEDVKVLPLDLASGE 107
Query: 129 KENYTLIREVAS---GLPVTVLINNVGKSHSIPVPFDQTEESELRDIITINNTATLMITQ 185
+ ++ + S G V L++N D +EE+ L+ +N T+ +T+
Sbjct: 108 ESLKHVVEQAVSLFPGAGVDYLVHNAAFERPKSKASDASEET-LKTTFDVNVFGTISLTK 166
Query: 186 TLLPQLKASVKTLKCRGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSNALAGELSSDSI 245
+ P + + G + + S G +P+P A YS SK L + ++L E I
Sbjct: 167 LVAPHM-----LKQGGGHFVVISSAAGKVPSPGQAIYSASKHALHGYFHSLRSEFCQKGI 221
Query: 246 DVELV 250
V +V
Sbjct: 222 KVTVV 226
>Hs4503817 [Q] KOG1210 Predicted 3-ketosphinganine reductase
Length = 332
Score = 66.6 bits (161), Expect = 5e-11
Identities = 52/176 (29%), Positives = 90/176 (50%), Gaps = 11/176 (6%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIETECKIDVKI---LAIDVS 125
VVTG S GIGK A + K+G + L++R E KL++ KKEIE D ++ +++DVS
Sbjct: 36 VVTGGSSGIGKCIAIECYKQGAFITLVARNEDKLLQAKKEIEMHSINDKQVVLCISVDVS 95
Query: 126 SDSKENYTLIREVASGL-PVTVLINNVGKSHSIPVPFDQTEESELRDIITINNTATLMIT 184
D + +I++ L PV +L+N G ++ F+ E S +++IN ++ +
Sbjct: 96 QDYNQVENVIKQAQEKLGPVDMLVNCAGM--AVSGKFEDLEVSTFERLMSINYLGSVYPS 153
Query: 185 QTLLPQLKASVKTLKCRGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSNALAGEL 240
+ ++ +K + G I+ + S G L YS SK ++ + AL E+
Sbjct: 154 RAVITTMKE-----RRVGRIVFVSSQAGQLGLFGFTAYSASKFAIRGLAEALQMEV 204
>7293522 [Q] KOG1207 Diacetyl reductase/L-xylulose reductase
Length = 242
Score = 66.6 bits (161), Expect = 5e-11
Identities = 58/192 (30%), Positives = 93/192 (48%), Gaps = 19/192 (9%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIETECKIDVKILAIDVSSDS 128
+VTGA GIG+ KQLA G +I ++R +L +++ + ++ L +D+S
Sbjct: 11 LVTGAGAGIGQALVKQLASAGATVIAVARKPEQL----QQLVAFDPVHIQPLQLDLS--- 63
Query: 129 KENYTLIREVASGLP-VTVLINNVGKSHSIPVPFDQTEESELRDIITINNTATLMITQTL 187
+ +RE + +P + L+NN G +I PF++ E + +N A +TQ+L
Sbjct: 64 --GWQAVREGLAKVPLLDGLVNNAGV--AIIKPFEELTEQDFDTHFDVNIKAVFNVTQSL 119
Query: 188 LPQLKASVKTLKCRGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSNALAGELSSDSIDV 247
LP+LK + I + SFGG YS +KA L S + +LA EL I V
Sbjct: 120 LPRLKDGASIVNVSS-IASSRSFGG------HTAYSATKAALDSLTKSLALELGPRKIRV 172
Query: 248 ELVLSYLVTSAM 259
V +V + M
Sbjct: 173 NSVNPTVVLTKM 184
>7300944 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 321
Score = 65.9 bits (159), Expect = 9e-11
Identities = 60/201 (29%), Positives = 102/201 (49%), Gaps = 25/201 (12%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIETECKIDVKILAIDVSS-- 126
VVTGA G+G+ + +LAK+G ++ ++ S + K+I+ K+ K +V++
Sbjct: 56 VVTGAGHGLGRAISLELAKKGCHIAVVDINVSGAEDTVKQIQDIYKVRAKAYKANVTNYD 115
Query: 127 DSKE-NYTLIREVASGLPVTVLINNVG----KSHSIPVPFDQTEESELRDIITINNTATL 181
D E N ++ E+ PVTVL+NN G ++ P P D ++ +I +N T+
Sbjct: 116 DLVELNSKVVEEMG---PVTVLVNNAGVMMHRNMFNPDPAD------VQLMINVNLTSHF 166
Query: 182 MITQTLLPQLKASVKTLKCRGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSNALAGELS 241
LP++K K G I+T+ S G+ P P+ ATY+ +K+ + L EL
Sbjct: 167 WTKLVFLPKMKELRK-----GFIVTISSLAGVFPLPYSATYTTTKSGALAHMRTLRMELD 221
Query: 242 SDS---IDVELVL-SYLVTSA 258
++ I V VL S+L T++
Sbjct: 222 LENQKDIHVTTVLPSFLRTNS 242
>Hs7706318 [Q] KOG1205 Predicted dehydrogenase
Length = 339
Score = 65.1 bits (157), Expect = 1e-10
Identities = 50/177 (28%), Positives = 87/177 (48%), Gaps = 12/177 (6%)
Query: 70 VTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIETECKI---DVKILAIDVSS 126
VTGAS GIG+E A QL+K G +L+L +R +L +K+ + D+ +L +D++
Sbjct: 55 VTGASSGIGEELAYQLSKLGVSLVLSARRVHELERVKRRCLENGNLKEKDILVLPLDLTD 114
Query: 127 DSKENYTLIREVASGLPVTVLINNVGKS-HSIPVPFDQTEESELRDIITINNTATLMITQ 185
+ + +L+NN G S S+ + T R +I +N T+ +T+
Sbjct: 115 TGSHEAATKAVLQEFGRIDILVNNGGMSQRSLCM---DTSLDVYRKLIELNYLGTVSLTK 171
Query: 186 TLLPQLKASVKTLKCRGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSNALAGELSS 242
+LP + + +G I+T+ S G++ P Y SK L+ + N L EL++
Sbjct: 172 CVLPHM-----IERKQGKIVTVNSILGIISVPLSIGYCASKHALRGFFNGLRTELAT 223
>7290108 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 270
Score = 65.1 bits (157), Expect = 1e-10
Identities = 51/185 (27%), Positives = 90/185 (48%), Gaps = 19/185 (10%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIETECKIDVKILAIDVSSDS 128
+VTGAS GIG A+ LA+ G L L+ R + L KK ++ +I+ DV+ D+
Sbjct: 9 IVTGASSGIGAAIAQVLAREGATLALVGRNVANLEATKKSLK---GTQAEIVVADVTKDA 65
Query: 129 KENYTLIREVASGLPVTVLINN---VGKSHSIPVPFDQTEESELRDIITINNTATLMITQ 185
+ + + +A + VL+NN +GK I + + E ++ N +++T+
Sbjct: 66 --DAIVQQTLAKFGRIDVLVNNAGILGKGGLIDLDIE-----EFDAVLNTNLRGVILLTK 118
Query: 186 TLLPQLKASVKTLKCRGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSNALAGELSSDSI 245
+LP L LK +G ++ + S G+ P +Y SKA L ++ +A E++ +
Sbjct: 119 AVLPHL------LKTKGAVVNVSSCAGIRPFAGALSYGVSKAALDQFTKIVALEMAPQGV 172
Query: 246 DVELV 250
V V
Sbjct: 173 RVNSV 177
>At3g47360 [Q] KOG1205 Predicted dehydrogenase
Length = 309
Score = 64.3 bits (155), Expect = 2e-10
Identities = 56/192 (29%), Positives = 92/192 (47%), Gaps = 8/192 (4%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIETECKIDVKILAIDVSSDS 128
++TGAS GIG+ A + AK+G L L++R +L + + +V I+ DVS+
Sbjct: 51 LITGASSGIGEHVAYEYAKKGAYLALVARRRDRLEIVAETSRQLGSGNVIIIPGDVSNVE 110
Query: 129 KENYTLIREVASGLPVTVLINNVGKSHSIPVPFDQTEESELRDIITINNTATLMITQTLL 188
+ + + LINN G ++ D T+ + I+ IN T IT +
Sbjct: 111 DCKKFIDETIRHFGKLDHLINNAGVFQTVLFE-DFTQIQDANPIMDINFWGTTYITYFAI 169
Query: 189 PQLKASVKTLKCRGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSNALAGELSSDSIDVE 248
P L+ K +G I+ + S +P P + Y+ SKA L + L ELS D I +
Sbjct: 170 PHLR------KSKGKIVAITSGSANIPLPLASIYAASKAALLRFFETLRIELSPD-IKIT 222
Query: 249 LVLSYLVTSAMS 260
+VL +V++ M+
Sbjct: 223 IVLPGVVSTDMT 234
>At3g47350 [Q] KOG1205 Predicted dehydrogenase
Length = 308
Score = 64.3 bits (155), Expect = 2e-10
Identities = 53/192 (27%), Positives = 92/192 (47%), Gaps = 8/192 (4%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIETECKIDVKILAIDVSSDS 128
++TGAS GIG+ A + AK+G L L++R + +L + + DV I+ DVS+
Sbjct: 50 LITGASSGIGEHVAYEYAKKGAKLALVARRKDRLEIVAETSRQLGSGDVIIIPGDVSNVE 109
Query: 129 KENYTLIREVASGLPVTVLINNVGKSHSIPVPFDQTEESELRDIITINNTATLMITQTLL 188
+ + + LINN G ++ + D T+ + I+ IN + IT +
Sbjct: 110 DCKKFIDETIHHFGKLDHLINNAGVPQTV-IFEDFTQIQDANSIMDINFWGSTYITYFAI 168
Query: 189 PQLKASVKTLKCRGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSNALAGELSSDSIDVE 248
P L+ K +G I+ + S ++P + YS SKA L + L E+S D I +
Sbjct: 169 PHLR------KSKGKIVVISSATAIIPLQAASVYSASKAALVKFFETLRVEISPD-IKIT 221
Query: 249 LVLSYLVTSAMS 260
+ L +++ M+
Sbjct: 222 IALPGFISTDMT 233
>CE27259 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 501
Score = 63.5 bits (153), Expect = 4e-10
Identities = 48/184 (26%), Positives = 89/184 (48%), Gaps = 10/184 (5%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIET--ECKIDVKILAIDVSS 126
+VTGAS GIG+ A LA+ + L L R + L EL +I + K DV + A++++S
Sbjct: 5 IVTGASSGIGRAAALLLARNNYKLSLTGRNVAALNELAGQIVSAGSDKNDVLVTAVELAS 64
Query: 127 DSKENYTLIREVASGLPVTVLINNVGKSHSIPVPFDQTEESELRDIITINNTATLMITQT 186
+ + V + LIN+ G + PV E + +++ +N + + +T+
Sbjct: 65 EEAPKTIVDATVQKFGRIDTLINSAGILRAGPVLDSGIEVYD--ELMNVNVRSLIRLTRA 122
Query: 187 LLPQLKASVKTLKCRGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSNALAGELSSDSID 246
LP + + +G ++ + S G P P + Y SK+ + ++ LA E++ + +
Sbjct: 123 ALPHI------ITTKGTVVNVSSINGPCPFPNVTYYCMSKSAVDQFTKCLALEMAPNGVR 176
Query: 247 VELV 250
V V
Sbjct: 177 VNAV 180
>SPAC521.03 [Q] KOG1205 Predicted dehydrogenase
Length = 259
Score = 63.2 bits (152), Expect = 6e-10
Identities = 63/201 (31%), Positives = 97/201 (47%), Gaps = 17/201 (8%)
Query: 69 VVTGASDGIGKEYAKQLAKRG-FNLILISRTESKLVELKKEIETECKIDVKILAIDVSSD 127
++TGAS GIGK A ++AK LIL +R S + E+ KE+E++ ++ V L +DV SD
Sbjct: 10 LITGASSGIGKSTAFEIAKVAKVKLILAARRFSTVEEIAKELESKYEVSVLPLKLDV-SD 68
Query: 128 SKENYTLIREVASGLP-----VTVLINNVGKSHSIPVPFDQTEESELRDIITINNTATLM 182
K I V LP + VLINN G + D + + +IT N +
Sbjct: 69 LKS----IPGVIESLPKEFADIDVLINNAGLALGTDKVIDLNIDDAV-TMITTNVLGMMA 123
Query: 183 ITQTLLPQLKASVKTLKCRGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSNALAGELSS 242
+T+ +LP + K +G IL +GS G + Y +K+ L +++AL E
Sbjct: 124 MTRAVLP-----IFYSKNKGDILNVGSIAGRESYVGGSVYCSTKSALAQFTSALRKETID 178
Query: 243 DSIDVELVLSYLVTSAMSKIR 263
I + V LV + S +R
Sbjct: 179 TRIRIMEVDPGLVETEFSVVR 199
>CE07539 [Q] KOG1205 Predicted dehydrogenase
Length = 537
Score = 63.2 bits (152), Expect = 6e-10
Identities = 52/174 (29%), Positives = 81/174 (45%), Gaps = 18/174 (10%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIETECKIDVK---ILAIDVS 125
V+TGAS G+GK A +L KRG +IL++R+ KL E+ E+ ++ D++
Sbjct: 82 VITGASSGLGKSLAFELYKRGAQVILLARSTEKLKEICAELTKTFPLNKNKPTYYFFDIT 141
Query: 126 SDSKENYTLIREVASGLPVTVLINNVGKSHSIPVPFDQTEESELRDIITINNTATLMITQ 185
+ K + I + V VLINN G S+ T + R + N + +TQ
Sbjct: 142 NPDKAPWAQIPK------VDVLINNAGMSNR--GSCQDTTMAIHRKAMETNLFGHVQVTQ 193
Query: 186 TLLPQLKASVKTLKCRGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSNALAGE 239
+LL +L G I+ S G + P+ +YS SK LQ + + L E
Sbjct: 194 SLLSKLSPD-------GCIVVTSSIQGKVAIPYRGSYSASKHALQGYFDCLRAE 240
>At3g06060 [Q] KOG1210 Predicted 3-ketosphinganine reductase
Length = 327
Score = 62.4 bits (150), Expect = 9e-10
Identities = 54/183 (29%), Positives = 86/183 (46%), Gaps = 12/183 (6%)
Query: 70 VTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIETECKIDVKILAIDVSSDSK 129
+TG S GIG A + A G + +++R+ SKL E KK I+ ++V + DV +
Sbjct: 44 ITGGSSGIGLALAHRAASEGARVSILARSGSKLEEAKKSIQLATGVEVATFSADV----R 99
Query: 130 ENYTLIREVASGLPVTVLINNVGKSHSIPVPFDQTEESELRDIITINNTATLMITQTLLP 189
+ + + + P+ VLI N G + + E +++ I +N + + + LP
Sbjct: 100 DYDAVSKAIDESGPIDVLIVNQGVFTAKELVKHSPE--DVKFTIDVNLVGSFNVIKAALP 157
Query: 190 QLKASVKTLKCRG--LILTMGSFGGLLPTPFLATYSGSKAFLQSWSNALAGELSSDSIDV 247
+KA K RG I + S G + A YS SK LQ + AL E+ SD I V
Sbjct: 158 AMKAR----KDRGPASISLVSSQAGQVGVYGYAAYSASKFGLQGLAQALQQEVISDDIHV 213
Query: 248 ELV 250
L+
Sbjct: 214 TLI 216
>Hs20149619 [Q] KOG1205 Predicted dehydrogenase
Length = 325
Score = 62.0 bits (149), Expect = 1e-09
Identities = 51/187 (27%), Positives = 89/187 (47%), Gaps = 12/187 (6%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIETECKIDVKI-LAIDVSSD 127
V+TGA+ G+GKE AK G L+L R L EL +E+ V+ V+ D
Sbjct: 56 VITGATSGLGKECAKVFYAAGAKLVLCGRNGGALEELIRELTASHATKVQTHKPYLVTFD 115
Query: 128 SKENYTLIREVASGLP----VTVLINNVGKSHSIPVPFDQTEESELRDIITINNTATLMI 183
++ ++ A L V +L+NN G S+ + D T + + R ++ N + +
Sbjct: 116 LTDSGAIVAAAAEILQCFGYVDILVNNAGISYRGTI-MDTTVDVDKR-VMETNYFGPVAL 173
Query: 184 TQTLLPQLKASVKTLKCRGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSNALAGELSSD 243
T+ LLP + + +G I+ + S G + PF + Y+ SK Q++ + L E+
Sbjct: 174 TKALLPSM-----IKRRQGHIVAISSIQGKMSIPFRSAYAASKHATQAFFDCLRAEMEQY 228
Query: 244 SIDVELV 250
I+V ++
Sbjct: 229 EIEVTVI 235
>At4g10020 [Q] KOG1205 Predicted dehydrogenase
Length = 389
Score = 61.6 bits (148), Expect = 2e-09
Identities = 50/176 (28%), Positives = 83/176 (46%), Gaps = 9/176 (5%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIETECKIDVKILAIDVSSDS 128
V+TGAS IG++ A + AKRG NL+L++R E +L + + + V I+A DV +
Sbjct: 53 VITGASSAIGEQIAYEYAKRGANLVLVARREQRLRVVSNKAKQIGANHVIIIAADVIKED 112
Query: 129 KENYTLIREVASGLPVTVLINNVGKSHSIPVPFDQTEESEL-RDIITINNTATLMITQTL 187
+ + V V L+N H+ F++ ++ + ++ IN + T
Sbjct: 113 DCRRFITQAVNYYGRVDHLVNTASLGHTF--YFEEVSDTTVFPHLLDINFWGNVYPTYVA 170
Query: 188 LPQLKASVKTLKCRGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSNALAGELSSD 243
LP L + G I+ S LP P ++ YS +KA L ++ L EL+ D
Sbjct: 171 LPYLH------QTNGRIVVNASVENWLPLPRMSLYSAAKAALVNFYETLRFELNGD 220
>Hs4504499 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 405
Score = 61.2 bits (147), Expect = 2e-09
Identities = 51/190 (26%), Positives = 91/190 (47%), Gaps = 23/190 (12%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKK----EIETECKIDVKILAIDV 124
++TG G GKE AK+L GF ++ + ++EL E+ T C +++L +D+
Sbjct: 86 LITGCDSGFGKETAKKLDSMGFTVL------ATVLELNSPGAIELRTCCSPRLRLLQMDL 139
Query: 125 SSDSKEN----YTLIREVASGLPVTVLINNVGKSHSIPVPFDQTEESELRDIITINNTAT 180
+ + +T ++GL L+NN G + + + + + R + +N
Sbjct: 140 TKPGDISRLLEFTKAHTTSTGL--WGLVNNAGHNEVV-ADAELSPVATFRSCMEVNFFGA 196
Query: 181 LMITQTLLPQLKASVKTLKCRGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSNALAGEL 240
L +T+ LLP L++S RG I+T+GS G +P P L Y SKA + + + EL
Sbjct: 197 LELTKGLLPLLRSS------RGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCEL 250
Query: 241 SSDSIDVELV 250
+ V ++
Sbjct: 251 LPWGVKVSII 260
>CE07544 [Q] KOG1205 Predicted dehydrogenase
Length = 262
Score = 61.2 bits (147), Expect = 2e-09
Identities = 53/192 (27%), Positives = 84/192 (43%), Gaps = 18/192 (9%)
Query: 51 VLPGPDFXXXXXXXXXXXVVTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIE 110
++PG V+TGAS G+GK A +L KRG +IL++R+ KL E+ +E++
Sbjct: 33 IIPGAHNLPKLDVKNKVVVITGASSGLGKSLAFELYKRGAQVILLARSTEKLKEICEELK 92
Query: 111 TECKIDVK---ILAIDVSSDSKENYTLIREVASGLPVTVLINNVGKSHSIPVPFDQTEES 167
++ D++ + + I V +LINN G S+ D T E
Sbjct: 93 ETFPLNQNEPIYYYFDITDSEQAPWAEIPR------VDILINNAGMSNRGSCQ-DTTMEI 145
Query: 168 ELRDIITINNTATLMITQTLLPQLKASVKTLKCRGLILTMGSFGGLLPTPFLATYSGSKA 227
R + N + +TQ LL +L G I+ S G + P+ +Y SK
Sbjct: 146 H-RQAMETNYFGHVHVTQALLSKLSPD-------GCIVVTSSIQGKVAIPYRGSYGASKH 197
Query: 228 FLQSWSNALAGE 239
LQ + + L E
Sbjct: 198 ALQGYFDCLRAE 209
>At2g37540 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 321
Score = 61.2 bits (147), Expect = 2e-09
Identities = 55/200 (27%), Positives = 93/200 (46%), Gaps = 26/200 (13%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEI-ETECKIDVKILAIDVSSD 127
++TG + GIG E A+ LA RG ++I+ +R E K+ I + V L IDVSS
Sbjct: 37 IITGGTSGIGLEAARVLAMRGAHVIIAARNPKAANESKEMILQMNPNARVDYLQIDVSSI 96
Query: 128 SKENYTLIREVASGLPVTVLINNVGKSHSIPVPFDQTEESELRDIITINNTATLMITQTL 187
+ + +A +P+ +LINN G PF TE+ + N+ ++T L
Sbjct: 97 KSVRSFVDQFLALNVPLNILINNAGVMF---CPFKLTEDG-IESQFATNHIGHFLLTNLL 152
Query: 188 LPQLKASVKTLKCRGLILTMGS------------FGGLLPTPFLATYSGSKAFLQS---- 231
L ++K++ + +G I+ + S F G+ A YS +A+ QS
Sbjct: 153 LDKMKSTARESGVQGRIVNLSSIAHTYTYSEGIKFQGINDP---AGYSERRAYGQSKLSN 209
Query: 232 --WSNALAGELSSDSIDVEL 249
SNAL+ L + +++ +
Sbjct: 210 LLHSNALSRRLQEEGVNITI 229
>At2g29370 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 268
Score = 61.2 bits (147), Expect = 2e-09
Identities = 57/197 (28%), Positives = 92/197 (45%), Gaps = 15/197 (7%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIETECKIDVKILAIDVSS-D 127
+VTG S G+GK ++LA G + +R E++L E +E + + + V DVSS D
Sbjct: 22 LVTGGSKGLGKAVVEELAMLGARVHTCARDETQLQESLREWQAK-GLQVTTSVCDVSSRD 80
Query: 128 SKENYTLIREVASGL---PVTVLINNVGKSHSIPVPFDQTEESELRDIITINNTATLMIT 184
+E + E S L +++L+ NVG + P + E II N +T +
Sbjct: 81 QREK---LMETVSSLFQGKLSILVPNVG--IGVLKPTTECTAEEFSFIIATNLESTFHFS 135
Query: 185 QTLLPQLKASVKTLKCRGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSNALAGELSSDS 244
Q P LKAS G I+ M S G++ + Y +K + + LA E +SD+
Sbjct: 136 QLAHPLLKASGS-----GNIVLMSSVAGVVNLGNTSIYGATKGAMNQLARNLACEWASDN 190
Query: 245 IDVELVLSYLVTSAMSK 261
I V + +T+ +K
Sbjct: 191 IRANSVCPWFITTPSTK 207
>CE27260 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 206
Score = 60.8 bits (146), Expect = 3e-09
Identities = 50/200 (25%), Positives = 96/200 (48%), Gaps = 13/200 (6%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIET--ECKIDVKILAIDVSS 126
+VTGAS GIG+ A LA+ + L L R + L EL +I + K DV + A++++S
Sbjct: 5 IVTGASSGIGRAAALLLARNNYKLSLTGRNVAALNELAGQIVSAGSDKNDVLVTAVELAS 64
Query: 127 DSKENYTLIREVASGLPVTVLINNVGKSHSIPVPFDQTEESELRDIITINNTATLMITQT 186
+ + V + LIN+ G + PV E + +++ +N + + +T+
Sbjct: 65 EEAPKTIVDATVQKFGRIDTLINSAGILRAGPVLDSGIEVYD--ELMNVNVRSLIRLTRA 122
Query: 187 LLPQLKASVKTLKCRGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSNALAGELSSDSID 246
LP + + +G ++ + S G P + Y SK+ + ++ LA E++ + +
Sbjct: 123 ALPHI------ITTKGTVVNVSSINGPCPFAGVTYYCMSKSAVDQFTKCLALEMAPNGVR 176
Query: 247 VELVLSYLVTSAMSKIRRSS 266
V V ++ ++ I R+S
Sbjct: 177 VNAVCPGVI---VTNIHRAS 193
>At5g19200 [Q] KOG1210 Predicted 3-ketosphinganine reductase
Length = 331
Score = 60.8 bits (146), Expect = 3e-09
Identities = 49/181 (27%), Positives = 83/181 (45%), Gaps = 8/181 (4%)
Query: 70 VTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIETECKIDVKILAIDVSSDSK 129
+TG S GIG A + G + +++R+ KL E K+ I+ ++V + DV +
Sbjct: 42 ITGGSSGIGLALAHRAVSEGAKVSILARSTEKLAEAKRSIQLATGVEVATFSADV----R 97
Query: 130 ENYTLIREVASGLPVTVLINNVGKSHSIPVPFDQTEESELRDIITINNTATLMITQTLLP 189
+ + + + P+ VLI N G I ++ E++ +I +N T + + + LP
Sbjct: 98 DYDAVSKAIDESGPIDVLIVNQGV--FIGKELEKQSPEEVKFMIDVNLTGSFNVIKAALP 155
Query: 190 QLKASVKTLKCRGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSNALAGELSSDSIDVEL 249
+KA + + I + S G YS SK LQ + AL E+ SD I V L
Sbjct: 156 AMKA--REGRGPASISLVSSQAGQAGIYGYTAYSASKFGLQGLAQALQQEVISDGIHVTL 213
Query: 250 V 250
+
Sbjct: 214 L 214
>7296705 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 257
Score = 60.8 bits (146), Expect = 3e-09
Identities = 48/182 (26%), Positives = 84/182 (45%), Gaps = 8/182 (4%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIETECKIDVKILAIDVSSDS 128
+VTGAS GIG + LAK G L ++ R KL E ++I +A D++S+S
Sbjct: 10 IVTGASSGIGAGTSVLLAKLGGLLTIVGRNLDKLNETAEQIVAAGGAPALQVAADINSES 69
Query: 129 KENYTLIREVASGLPVTVLINNVGKSHSIPVPFDQTEESELRDIITINNTATLMITQTLL 188
+ +A + VL+NN G + + T + ++ N + +T +
Sbjct: 70 DVQGIVSATLAKHGRIDVLVNNAGILELGSI--ENTSLEQFDRVMNTNVRSLYQLTHLVT 127
Query: 189 PQLKASVKTLKCRGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSNALAGELSSDSIDVE 248
P+L +K +G I+ + S G+ P + Y+ SKA + ++ +A EL+ + V
Sbjct: 128 PEL------IKTKGNIVNVSSVNGIRSFPGVLAYNVSKAAVDQFTRCVALELAPKGVRVN 181
Query: 249 LV 250
V
Sbjct: 182 SV 183
>7301818 [Q] KOG1205 Predicted dehydrogenase
Length = 326
Score = 60.1 bits (144), Expect = 5e-09
Identities = 49/195 (25%), Positives = 97/195 (49%), Gaps = 10/195 (5%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKE---IETECKIDVKILAIDVS 125
++TGAS G+G+ A + G +IL +R +L +KK+ ++ + +L +D++
Sbjct: 57 LITGASSGLGESLAHVFYRAGCRVILAARRTQELERVKKDLLALDVDPAYPPTVLPLDLA 116
Query: 126 SDSKENYTLIREVASGLPVTVLINNVGKSHSIPVPFDQTEESELRDIITINNTATLMITQ 185
+ + R +A V +LINN G S V + +L+ ++ +N ++ +T+
Sbjct: 117 ELNSIPEFVTRVLAVYNQVDILINNGGISVRADVA-STAVDVDLK-VMVVNYFGSVALTK 174
Query: 186 TLLPQLKASVKTLKCRGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSNALAGELSSDSI 245
LLP + + G I + S G P A YS SK +Q+++++L E+++ +I
Sbjct: 175 ALLPSM-----VKRGSGHICFISSVQGKFAIPQRAAYSASKHAMQAFADSLRAEVANKNI 229
Query: 246 DVELVLSYLVTSAMS 260
+V V + + +S
Sbjct: 230 NVSCVSPGYIRTQLS 244
>At2g29150 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 268
Score = 59.7 bits (143), Expect = 6e-09
Identities = 54/195 (27%), Positives = 93/195 (47%), Gaps = 14/195 (7%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIETECKIDVKILAIDVSSDS 128
+VTG S G+G+ ++LA G + +R E++L E +E + + +V DVS S
Sbjct: 22 LVTGGSKGLGEAVVEELAMLGARVHTCARDETQLQERLREWQAK-GFEVTTSVCDVS--S 78
Query: 129 KENYTLIREVASGL---PVTVLINNVGKSHSIPVPFDQTEESELRDIITINNTATLMITQ 185
+E + E S + + +L+NN G I P + + ++ N + ++Q
Sbjct: 79 REQREKLMETVSSVFQGKLNILVNNAGT--GIIKPSTEYTAEDYSFLMATNLESAFHLSQ 136
Query: 186 TLLPQLKASVKTLKCRGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSNALAGELSSDSI 245
P LKAS G I+ M S GL+ T + Y SK + +LA E +SD+I
Sbjct: 137 IAHPLLKASGS-----GSIVFMSSVAGLVHTG-ASIYGASKGAMNQLGRSLACEWASDNI 190
Query: 246 DVELVLSYLVTSAMS 260
V V +++T+ ++
Sbjct: 191 RVNSVCPWVITTPLT 205
>YIL124w [Q] KOG1209 1-Acyl dihydroxyacetone phosphate reductase and related
dehydrogenases
Length = 297
Score = 58.9 bits (141), Expect = 1e-08
Identities = 50/182 (27%), Positives = 88/182 (47%), Gaps = 15/182 (8%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIETECKIDVKILAIDVSSDS 128
VVTGAS GIG E K+LA+ G+ + +R + +L + + +K +D+S
Sbjct: 13 VVTGASGGIGYEVTKELARNGYLVYACARRLEPMAQLAIQFGND---SIKPYKLDISK-P 68
Query: 129 KENYTLIREVASGLP---VTVLINNVGKSHSIPVPFDQTEESELRDIITINNTATLMITQ 185
+E T + + LP + +L NN G+S + P D T ++ + +N + + +
Sbjct: 69 EEIVTFSGFLRANLPDGKLDLLYNNAGQSCTFPA-LDAT-DAAVEQCFKVNVFGHINMCR 126
Query: 186 TLLPQLKASVKTLKCRGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSNALAGELSSDSI 245
L S +K +G I+ GS G++ PF + YS SKA + ++ L E+ ++
Sbjct: 127 EL------SEFLIKAKGTIVFTGSLAGVVSFPFGSIYSASKAAIHQYARGLHLEMKPFNV 180
Query: 246 DV 247
V
Sbjct: 181 RV 182
>At2g29350 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 269
Score = 58.9 bits (141), Expect = 1e-08
Identities = 53/195 (27%), Positives = 91/195 (46%), Gaps = 13/195 (6%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIETECKIDVKILAIDVSSDS 128
+VTG S GIG+ ++LA G + +R E++L E +E + + V DVS S
Sbjct: 21 LVTGGSKGIGEAVVEELAMLGAKVHTCARDETQLQERLREWQAK-GFQVTTSVCDVS--S 77
Query: 129 KENYTLIREVASGL---PVTVLINNVGKSHSIPVPFDQTEESELRDIITINNTATLMITQ 185
++ + E S L + +L+NNVG SI P + + ++ N + ++Q
Sbjct: 78 RDQRVKLMETVSSLYQGKLNILVNNVGT--SIFKPTTEYTAEDFSFVMATNLESAFHLSQ 135
Query: 186 TLLPQLKASVKTLKCRGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSNALAGELSSDSI 245
P LKAS G I+ + S G++ + Y +K + + LA E +SD+I
Sbjct: 136 LAHPLLKASGS-----GSIVLISSAAGVVHVNVGSIYGATKGAMNQLARNLACEWASDNI 190
Query: 246 DVELVLSYLVTSAMS 260
V + +T+ +S
Sbjct: 191 RTNSVCPWYITTPLS 205
>CE06316 [Q] KOG1207 Diacetyl reductase/L-xylulose reductase
Length = 251
Score = 58.2 bits (139), Expect = 2e-08
Identities = 51/188 (27%), Positives = 84/188 (44%), Gaps = 14/188 (7%)
Query: 76 GIGKEYAKQLAKRGFNLILISRTESKLVELKKEIETECKIDVKILAIDVSSDSKENYTLI 135
GIGKE LAK G +I +R E+ L+ L KE T + + + DVS++ + L
Sbjct: 20 GIGKEICLSLAKAGAQVIAFARNEANLLSLVKE-TTSLRYTIIPIVGDVSANEE---VLF 75
Query: 136 REVASGLPVTVLINNVG--KSHSIPVPFDQTEESELRDIITINNTATLMITQTLLPQLKA 193
+ + P+ L+NN G +H+I Q + + +N ++I Q +
Sbjct: 76 KLIVPHFPIHGLVNNAGIATNHAI----GQITQQSIDRTFAVNVRGPILIAQL----VAR 127
Query: 194 SVKTLKCRGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSNALAGELSSDSIDVELVLSY 253
+ + +G I+ + S + P Y SKA L + LA EL S +I V V
Sbjct: 128 NFVDRQIKGSIVNISSQAAIRPLDNHTVYCASKAALDMVTRCLANELGSQNIRVNSVNPT 187
Query: 254 LVTSAMSK 261
+V + M +
Sbjct: 188 VVMTDMGR 195
>Hs5031765 [Q] KOG1205 Predicted dehydrogenase
Length = 292
Score = 57.8 bits (138), Expect = 2e-08
Identities = 47/193 (24%), Positives = 93/193 (47%), Gaps = 22/193 (11%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIETECKIDVKILAIDVSSDS 128
+VTGAS GIG+E A LAK G ++++ +R++ L +++ + C +++ + + +
Sbjct: 38 IVTGASKGIGREMAYHLAKMGAHVVVTARSKETL----QKVVSHC-LELGAASAHYIAGT 92
Query: 129 KENYTLIRE-------VASGLPVTVLINNVGKSHSIPVPFDQTEESELRDIITINNTATL 181
E+ T + + GL + +L + S ++ + +R + +N + +
Sbjct: 93 MEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNL----FHDDIHHVRKSMEVNFLSYV 148
Query: 182 MITQTLLPQLKASVKTLKCRGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSNALAGELS 241
++T LP LK S G I+ + S G + P +A YS SK L + +++ E S
Sbjct: 149 VLTVAALPMLKQS------NGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYS 202
Query: 242 SDSIDVELVLSYL 254
++V + L L
Sbjct: 203 VSRVNVSITLCVL 215
>At5g50690 [Q] KOG1205 Predicted dehydrogenase
Length = 303
Score = 57.8 bits (138), Expect = 2e-08
Identities = 52/188 (27%), Positives = 90/188 (47%), Gaps = 10/188 (5%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIETECKIDVKILAIDVSSDS 128
++TG+S GIG+ A + A+RG L L++R E +L + DV ++ DVS
Sbjct: 51 IITGSSSGIGEHLAYEYARRGAYLTLVARREDRLQVVADRCRKLGSPDVAVVRGDVSV-I 109
Query: 129 KENYTLIREVASGL-PVTVLINNVGKSHSIPVPFDQTEESELRDIITINNTATLMITQTL 187
K+ ++E S + L+NN G + + D +E S++ I+ N + T
Sbjct: 110 KDCKRFVQETISRFGRLDHLVNNAGIAEA-KFFEDYSEISDVLPIVNTNFWGPVYATHFA 168
Query: 188 LPQLKASVKTLKCRGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSNALAGELSSDSIDV 247
+P LK K +G I+ + S G P ++ Y+ SKA + ++ L EL + + V
Sbjct: 169 IPHLK------KTKGKIIAVASPAGWSGVPRMSIYAASKAAMINFYETLRIELHPE-VGV 221
Query: 248 ELVLSYLV 255
+V L+
Sbjct: 222 TIVFPGLI 229
>At5g50590 [Q] KOG1205 Predicted dehydrogenase
Length = 299
Score = 57.8 bits (138), Expect = 2e-08
Identities = 52/188 (27%), Positives = 90/188 (47%), Gaps = 10/188 (5%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIETECKIDVKILAIDVSSDS 128
++TG+S GIG+ A + A+RG L L++R E +L + DV ++ DVS
Sbjct: 51 IITGSSSGIGEHLAYEYARRGAYLTLVARREDRLQVVADRCRKLGSPDVAVVRGDVSV-I 109
Query: 129 KENYTLIREVASGL-PVTVLINNVGKSHSIPVPFDQTEESELRDIITINNTATLMITQTL 187
K+ ++E S + L+NN G + + D +E S++ I+ N + T
Sbjct: 110 KDCKRFVQETISRFGRLDHLVNNAGIAEA-KFFEDYSEISDVLPIVNTNFWGPVYATHFA 168
Query: 188 LPQLKASVKTLKCRGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSNALAGELSSDSIDV 247
+P LK K +G I+ + S G P ++ Y+ SKA + ++ L EL + + V
Sbjct: 169 IPHLK------KTKGKIIAVASPAGWSGVPRMSIYAASKAAMINFYETLRIELHPE-VGV 221
Query: 248 ELVLSYLV 255
+V L+
Sbjct: 222 TIVFPGLI 229
>Hs4504503 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 387
Score = 57.4 bits (137), Expect = 3e-08
Identities = 46/181 (25%), Positives = 83/181 (45%), Gaps = 11/181 (6%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIETECKIDVKILAIDVSS-- 126
+VTG G+G K L + GF + E+ +E+ C + +L +D++
Sbjct: 86 LVTGGDCGLGHALCKYLDELGFTVFAGVLNENG--PGAEELRRTCSPRLSVLQMDITKPV 143
Query: 127 DSKENYTLIREVASGLPVTVLINNVGKSHSIPVPFDQTEESELRDIITINNTATLMITQT 186
K+ Y+ + + + +INN G P + ++ + + +N T+ +T+T
Sbjct: 144 QIKDAYSKVAAMLQDRGLWAVINNAGVL-GFPTDGELLLMTDYKQCMAVNFFGTVEVTKT 202
Query: 187 LLPQLKASVKTLKCRGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSNALAGELSSDSID 246
LP L+ K +G ++ + S GG P LA+Y SKA + +S+ + ELS I
Sbjct: 203 FLPLLR------KSKGRLVNVSSMGGGAPMERLASYGSSKAAVTMFSSVMRLELSKWGIK 256
Query: 247 V 247
V
Sbjct: 257 V 257
>CE03954 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 274
Score = 57.4 bits (137), Expect = 3e-08
Identities = 55/214 (25%), Positives = 95/214 (43%), Gaps = 15/214 (7%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIETE--CKIDVKILAIDVSS 126
++TG+S+GIG+ A LA G + + R ++L E ++ I +V + DV++
Sbjct: 10 IITGSSNGIGRATAVLLATDGAKVTITGRDAARLEETRQAILKAGISATNVNSVVADVTT 69
Query: 127 DSKENYTLIREVASGLPVTVLINNVGKSHSIPVPFDQTEE----SELRDIITINNTATLM 182
++ + + + +LINN G +IP QT L + +N + +
Sbjct: 70 AEGQDLLISSTLDKFGKINILINNAGA--NIPDSQGQTRTKCSIENLTKMFQLNLQSVVE 127
Query: 183 ITQTLLPQLKASVKTLKCRGLILTMGSFG-GLLPTPFLATYSGSKAFLQSWSNALAGELS 241
+ Q + P L K RG I+ + S G G P YS +KA L +S A +L
Sbjct: 128 MVQKVRPHL------AKTRGEIVNISSIGAGPAAQPASPYYSSAKAALDQYSRCAAIDLI 181
Query: 242 SDSIDVELVLSYLVTSAMSKIRRSSALIPSPKAF 275
S+ I + +V V++ S R + S K +
Sbjct: 182 SEGIRINVVQPGFVSTGFSTAARGLSADESVKFY 215
>At5g10050 [Q] KOG1209 1-Acyl dihydroxyacetone phosphate reductase and related
dehydrogenases
Length = 299
Score = 57.4 bits (137), Expect = 3e-08
Identities = 51/198 (25%), Positives = 94/198 (46%), Gaps = 30/198 (15%)
Query: 69 VVTGASDG-IGKEYAKQLAKRGFNLILISRTESKLVELKKEIETECKIDVKILAIDVSSD 127
++TG S G IG A++ ++G ++ SR+ S + +L E + ++ VK L DV SD
Sbjct: 11 LITGCSQGGIGHALAREFTEKGCRVVATSRSRSTMTDL----EQDSRLFVKEL--DVQSD 64
Query: 128 SKENYTLIREVASGLPVTVLINNVGKSHSIPV---PFDQTEES------ELRDII----- 173
+ L + + VL+NN G P+ P E + +D+I
Sbjct: 65 QNVSKVLSEVIDKFGKIDVLVNNAGVQCVGPLAETPISAMENTFNTNVFGNKDLIFSFNY 124
Query: 174 ----TINNTATLMITQTLLPQLKASVKTLKCRGLILTMGSFGGLLPTPFLATYSGSKAFL 229
+ N++ ++ +TQ ++P + + K +G I+ +GS + P P+ Y+ +KA +
Sbjct: 125 YIYWSFNSSGSMRMTQAVVPHMVS-----KKKGKIVNVGSITVMAPGPWAGVYTATKAAI 179
Query: 230 QSWSNALAGELSSDSIDV 247
+ ++ L EL IDV
Sbjct: 180 HALTDTLRLELRPFGIDV 197
>At3g55310 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 298
Score = 57.4 bits (137), Expect = 3e-08
Identities = 54/197 (27%), Positives = 88/197 (44%), Gaps = 9/197 (4%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIE--TECKIDVKILAIDVSS 126
+VTGAS GIG+E LAK G +I +R +L L EI + I L +DVSS
Sbjct: 42 LVTGASSGIGREICLDLAKAGCQVIAAARRVDRLNSLCSEINSFSSTGIQAAALELDVSS 101
Query: 127 DSKENYTLIREVASGL-PVTVLINNVGKSHSIPVPFDQTEESELRDIITINNTATLMITQ 185
D+ +RE + LINN G ++ + D +E+ E ++ N ++ +
Sbjct: 102 DAATIQKAVREAWDIFGKIDALINNAGIRGNVKLSLDLSED-EWDNVFNTNLKGPWLVAK 160
Query: 186 TLLPQLKASVKTLKCRGLILTMGSFGGLLP-TPFLATYSGSKAFLQSWSNALAGELSSDS 244
+ ++ K G ++ + S G+ P YS SK + + S +A EL
Sbjct: 161 YVC----VLMRDAKRGGSVINISSVAGVRSIVPGGLAYSCSKGGVDTMSRMMAIELGVHK 216
Query: 245 IDVELVLSYLVTSAMSK 261
I V + L S +++
Sbjct: 217 IRVNSIAPGLFKSEITQ 233
>At3g46170 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 288
Score = 57.0 bits (136), Expect = 4e-08
Identities = 52/201 (25%), Positives = 91/201 (44%), Gaps = 17/201 (8%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIETECK--IDVKILAIDVSS 126
+VTGAS GIG+E L K G +I ++R +L L EI + I L +DV+S
Sbjct: 32 LVTGASSGIGREICLDLGKAGCKIIAVARRVDRLNSLCSEINSSSSTGIQAAALKLDVTS 91
Query: 127 DSKENYTLIREVASGL-----PVTVLINNVGKSHSIPVPFDQTEESELRDIITINNTATL 181
D+ I++V G + LINN G ++ D ++E E ++ N T
Sbjct: 92 DA----ATIQKVVQGAWGIFGKIDALINNAGIRGNVKSSLDLSKE-EWDNVFKTNLTGPW 146
Query: 182 MITQTLLPQLKASVKTLKCRGLILTMGSFGGLLP-TPFLATYSGSKAFLQSWSNALAGEL 240
++++ + ++ K G ++ + S G+ P Y+ SK + + S +A EL
Sbjct: 147 LVSKYVC----VLMRDAKLGGSVINISSIAGIRGILPGALAYACSKIGVDTMSKMMAVEL 202
Query: 241 SSDSIDVELVLSYLVTSAMSK 261
I V + + S +++
Sbjct: 203 GVHKIRVNSIAPGIFKSEITQ 223
>At1g10310 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 242
Score = 56.6 bits (135), Expect = 5e-08
Identities = 52/211 (24%), Positives = 102/211 (47%), Gaps = 15/211 (7%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIETECKIDVKILAIDVSSDS 128
++TG S G+G+ A +LAKRG +I +R++ KL L+ E+ + + +L DV S+S
Sbjct: 21 LITGVSKGLGRALALELAKRGHTVIGCARSQEKLTALQSELSS--STNHLLLTADVKSNS 78
Query: 129 KEN---YTLIREVASGLPVTVLINNVGKSHSIPVPFDQTEESELRDIITINNTATLMITQ 185
+T++ + G+P +++NN G + ++ + E + +++ N + +
Sbjct: 79 SVEEMAHTIVEK--KGVP-DIIVNNAGTINKNSKIWEVSAE-DFDNVMDTNVKGVANVLR 134
Query: 186 TLLPQLKASVKTLKCRGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSNALAGELSSDSI 245
+P + + +G+I+ M S G +A Y SK ++ S A+A E+
Sbjct: 135 HFIPLMLP-----RKQGIIVNMSSGWGRSGAALVAPYCASKWAIEGLSRAVAKEVVEGMA 189
Query: 246 DVELVLSYLVTSAM-SKIRRSSALIPSPKAF 275
V L + T + S S++L +P A+
Sbjct: 190 VVALNPGVINTELLTSCFGNSASLYQAPDAW 220
>7300947 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 361
Score = 56.6 bits (135), Expect = 5e-08
Identities = 44/179 (24%), Positives = 80/179 (44%), Gaps = 9/179 (5%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIETECKIDVKILAIDVSSDS 128
+VTG G+G+E +LA+RG L ++ E + + + K DVSS
Sbjct: 96 LVTGGGSGLGREICLELARRGCKLAVVDVNSKGCYETVELLSKIPRCVAKAYKNDVSS-P 154
Query: 129 KENYTLIREVASGL-PVTVLINNVGKSHSIPVPFDQTEESELRDIITINNTATLMITQTL 187
+E + +V L PV +L+NN P + E+ I+ +N + +M T+
Sbjct: 155 RELQLMAAKVEKELGPVDILVNNASLMPMTSTP--SLKSDEIDTILQLNLGSYIMTTKEF 212
Query: 188 LPQLKASVKTLKCRGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSNALAGELSSDSID 246
LP++ + G ++ + + GL+P P Y+ +K ++ + +L EL D
Sbjct: 213 LPKM-----INRKSGHLVAVNALAGLVPLPGAGIYTATKYGIEGFMESLRAELRLSDCD 266
>CE03132 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 278
Score = 56.2 bits (134), Expect = 7e-08
Identities = 59/231 (25%), Positives = 103/231 (44%), Gaps = 23/231 (9%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIETE--CKIDVKILAIDVSS 126
++TG+S GIG+E A AK G + + R+E KL E KK + + + I+ D++
Sbjct: 11 IITGSSSGIGRETALLFAKEGAKVTVTGRSEEKLEETKKALLDAGIKESNFLIVPADITF 70
Query: 127 DSKENYTLIREVASGLPVTVLINNVGKSHSIP-----VPFDQTEESELRDIITINNTATL 181
+ ++ + + + + +L+NN G SIP DQ E+ ++ +N + +
Sbjct: 71 STGQDELISQTLKKFGRINILVNNAGA--SIPDAKKRTGIDQGIET-YEQVMKLNVQSVI 127
Query: 182 MITQTLLPQLKASVKTLKCRGLILTMGSF----GGLLPTPFLATYSGSKAFLQSWSNALA 237
+TQ + P L K RG I+ + S G TP+ Y +KA L ++ + A
Sbjct: 128 EMTQKVRPHL------AKSRGEIVNVSSVVALKAGWTRTPY---YPLAKAALDQYTRSAA 178
Query: 238 GELSSDSIDVELVLSYLVTSAMSKIRRSSALIPSPKAFVRSTLNSIGKRCG 288
L S+ I V V +V + S+ + K + N+ CG
Sbjct: 179 IALISEGIRVNTVNPGIVQTGFQANASGSSSDDAQKFYDDMGSNTTAIPCG 229
>SPAC3G9.02 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 236
Score = 55.8 bits (133), Expect = 9e-08
Identities = 51/212 (24%), Positives = 96/212 (45%), Gaps = 8/212 (3%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIETECKIDVKILAIDVSSDS 128
++TG S G+GK A+ +++G ++ R E L E + + + DV SD
Sbjct: 5 LITGGSSGLGKRIAQIWSQKGHQCHIVGRNEFHLKETLQSLSVAKGQQHTLTIADVQSDM 64
Query: 129 KENYTLIREVASGLPVTVLINNVGKSHSIPVPFDQTEESELRDIITINNTATLMITQTLL 188
K ++ + + + +++ G S +T E E+ II N + + +++ +
Sbjct: 65 KN----LKSIFESVEIDTVVHAAGVLQSSLCV--RTSEKEIDSIICTNLVSAIKLSKMAI 118
Query: 189 PQLKASVKTLKCRGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSNALAGELSSDSIDVE 248
+ + + + R LIL + S P + Y+ SKA L+S++ LA E++S I V
Sbjct: 119 LEWFRNKNSERDR-LILNISSRLSTYALPGTSVYAASKAGLESFTKVLAAEVASKGIRVN 177
Query: 249 LVL-SYLVTSAMSKIRRSSALIPSPKAFVRST 279
+ Y+ T +S R+ A P + ST
Sbjct: 178 AISPGYVDTPMLSSQIRAIAEKKVPIGRLAST 209
>CE05526 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 278
Score = 55.8 bits (133), Expect = 9e-08
Identities = 46/192 (23%), Positives = 89/192 (45%), Gaps = 7/192 (3%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIETE--CKIDVKILAIDVSS 126
++TG+S+GIG+ A A+ G + + R +L E +++I + +V + DV++
Sbjct: 10 IITGSSNGIGRATAVLFAREGAKVTITGRHAERLEETRQQILAAGVSEQNVNSVVADVTT 69
Query: 127 DSKENYTLIREVASGLPVTVLINNVGKSHSIPVPFDQTEESELRDIITINNTATLMITQT 186
D+ ++ L + + +L+NN G + +P Q++ + I + + T L +
Sbjct: 70 DAGQDEILSTTLGKFGKLDILVNNAGAA----IPDSQSKTGTAQSIESYDATLNLNLRSV 125
Query: 187 LLPQLKASVKTLKCRGLILTMGSF-GGLLPTPFLATYSGSKAFLQSWSNALAGELSSDSI 245
+ KA +G I+ + S GL TP YS +KA + ++ A +L I
Sbjct: 126 IALTKKAVPHLSSTKGEIVNISSIASGLHATPDFPYYSIAKAAIDQYTRNTAIDLIQHGI 185
Query: 246 DVELVLSYLVTS 257
V + LV +
Sbjct: 186 RVNSISPGLVAT 197
>At4g24050 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 332
Score = 55.8 bits (133), Expect = 9e-08
Identities = 42/143 (29%), Positives = 72/143 (49%), Gaps = 7/143 (4%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIETEC-KIDVKILAIDVSSD 127
V+TGA+ GIG E A+ LAKRG LI +R E K+ I +E + ++ ++ +D+SS
Sbjct: 38 VITGATSGIGAETARVLAKRGARLIFPARNVKAAEEAKERIVSEFPETEIVVMKLDLSSI 97
Query: 128 SKENYTLIREVASGLPVTVLINNVGK-SHSIPVPFDQTEESELRDIITINNTATLMITQT 186
+ + + LP+ +LINN GK +H + D E + N ++T
Sbjct: 98 ASVRNFVADFESLDLPLNLLINNAGKLAHEHAISEDGIEMT-----FATNYLGHFLLTNL 152
Query: 187 LLPQLKASVKTLKCRGLILTMGS 209
LL ++ + + +G I+ + S
Sbjct: 153 LLNKMIQTAEETGVQGRIVNVTS 175
>At2g29290 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 262
Score = 55.8 bits (133), Expect = 9e-08
Identities = 53/194 (27%), Positives = 88/194 (45%), Gaps = 13/194 (6%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIETECKIDVKILAIDVSSDS 128
+VTG + GIG+ ++L+ G + +R E++L E +E + E V DVS
Sbjct: 13 LVTGGTKGIGEAVVEELSILGARVHTCARDETQLQERLREWQ-EKGFQVTTSICDVSL-- 69
Query: 129 KENYTLIREVASGL---PVTVLINNVGKSHSIPVPFDQTEESELRDIITINNTATLMITQ 185
+E + E S L + +L+NNVG P EE ++ N + I+Q
Sbjct: 70 REQREKLMETVSSLFQGKLNILVNNVGTLMLKPTTEYTAEEFSF--LMATNLDSAFHISQ 127
Query: 186 TLLPQLKASVKTLKCRGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSNALAGELSSDSI 245
P LKAS G I+ M S G++ + Y +K + + LA E +SD+I
Sbjct: 128 LAHPLLKASGS-----GSIVLMSSIAGVVHVGVGSIYGATKGAMNQLARNLACEWASDNI 182
Query: 246 DVELVLSYLVTSAM 259
+ +L+T+ +
Sbjct: 183 RTNAICPWLITTPL 196
>7296047 [Q] KOG1205 Predicted dehydrogenase
Length = 321
Score = 55.8 bits (133), Expect = 9e-08
Identities = 50/186 (26%), Positives = 91/186 (48%), Gaps = 14/186 (7%)
Query: 70 VTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIETECK-----IDVKILAIDV 124
+TGAS GIG+ A LA+ G L+L +R +L ++++E + DV ++ +D+
Sbjct: 51 ITGASSGIGRALALSLARHGVKLVLSARRLEQLEQVQEECLAAARGLLATKDVLVIQMDM 110
Query: 125 SSDSKENYTLIREVASGL-PVTVLINNVGKSHSIPVPFDQTEESELRDIITINNTATLMI 183
D E+ T + V + + VL+NN G+S + + E R++ ++ A + +
Sbjct: 111 -LDLDEHKTHLNTVLNHFHRLDVLVNNAGRSQR--ASWTEVEIEVDRELFELDVFAVVHL 167
Query: 184 TQTLLPQLKASVKTLKCRGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSNALAGELSSD 243
++ + ++ V+ RG I S G P PF TY +K L ++ +L E+
Sbjct: 168 SRLV---VRYFVEQNGGRGHIAATSSIAGFSPVPFSPTYCAAKHALNAYLLSLKVEMR-- 222
Query: 244 SIDVEL 249
+DV L
Sbjct: 223 KLDVSL 228
>At2g29170 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 268
Score = 55.1 bits (131), Expect = 2e-07
Identities = 52/194 (26%), Positives = 90/194 (45%), Gaps = 13/194 (6%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIETECKIDVKILAIDVSS-D 127
+VTG S G+G+ ++LA G + +R E++L E +E + + +V DVSS D
Sbjct: 22 LVTGGSKGLGEAVVEELAMLGARVHTCARNETQLQECVREWQAK-GFEVTTSVCDVSSRD 80
Query: 128 SKENYTLIREVASGL--PVTVLINNVGKSHSIPVPFDQTEESELRDIITINNTATLMITQ 185
+E L+ VAS + +L+NN G I P + + ++ N + ++Q
Sbjct: 81 QREK--LMENVASIFQGKLNILVNNAGT--GITKPTTEYTAQDYSFLMATNLDSAFHLSQ 136
Query: 186 TLLPQLKASVKTLKCRGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSNALAGELSSDSI 245
P LKAS G I+ M S G++ + Y +K + + LA E + D+I
Sbjct: 137 LAHPLLKASGS-----GSIVLMSSTAGVVHINVGSIYGATKGAMNQLAKNLACEWARDNI 191
Query: 246 DVELVLSYLVTSAM 259
V V + + + +
Sbjct: 192 RVNSVCPWFIATPL 205
>At5g50700 [Q] KOG1205 Predicted dehydrogenase
Length = 349
Score = 54.7 bits (130), Expect = 2e-07
Identities = 60/252 (23%), Positives = 106/252 (41%), Gaps = 25/252 (9%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIETECKIDVKILAIDVSSDS 128
++TGAS GIG++ A + A RG L L +R +++L E+ + +V + DVS
Sbjct: 51 LITGASSGIGEQLAYEYACRGACLALTARRKNRLEEVAEIARELGSPNVVTVHADVSKPD 110
Query: 129 KENYTLIREVASGLPVTVLINNVGKSHSIPVPFDQTEE-SELRDIITINNTATLMITQTL 187
+ + + L+NN G + F+ E+ + + ++ N ++ T+
Sbjct: 111 DCRRIVDDTITHFGRLDHLVNNAGMTQI--SMFENIEDITRTKAVLDTNFWGSVYTTRAA 168
Query: 188 LPQLKASVKTLKCRGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSNALAGELSSDSIDV 247
LP L+ S G I+ M S L P ++ Y+ SKA L S+ + EL D + +
Sbjct: 169 LPYLRQS------NGKIVAMSSSAAWLTAPRMSFYNASKAALLSFFETMRIELGGD-VHI 221
Query: 248 ELVLSYLVTSAMSKIR--------------RSSALIPSPKAFVRSTLNSIGKRCGAQERF 293
+V + S +++ + R + P P A SI ++R+
Sbjct: 222 TIVTPGYIESELTQGKYFSGEGELIVNQDMRDVQVGPFPVASASGCAKSIVNGVCRKQRY 281
Query: 294 ATSTPYWSHALY 305
T P W Y
Sbjct: 282 VTE-PSWFKVTY 292
>At5g50600 [Q] KOG1205 Predicted dehydrogenase
Length = 349
Score = 54.7 bits (130), Expect = 2e-07
Identities = 60/252 (23%), Positives = 106/252 (41%), Gaps = 25/252 (9%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIETECKIDVKILAIDVSSDS 128
++TGAS GIG++ A + A RG L L +R +++L E+ + +V + DVS
Sbjct: 51 LITGASSGIGEQLAYEYACRGACLALTARRKNRLEEVAEIARELGSPNVVTVHADVSKPD 110
Query: 129 KENYTLIREVASGLPVTVLINNVGKSHSIPVPFDQTEE-SELRDIITINNTATLMITQTL 187
+ + + L+NN G + F+ E+ + + ++ N ++ T+
Sbjct: 111 DCRRIVDDTITHFGRLDHLVNNAGMTQI--SMFENIEDITRTKAVLDTNFWGSVYTTRAA 168
Query: 188 LPQLKASVKTLKCRGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSNALAGELSSDSIDV 247
LP L+ S G I+ M S L P ++ Y+ SKA L S+ + EL D + +
Sbjct: 169 LPYLRQS------NGKIVAMSSSAAWLTAPRMSFYNASKAALLSFFETMRIELGGD-VHI 221
Query: 248 ELVLSYLVTSAMSKIR--------------RSSALIPSPKAFVRSTLNSIGKRCGAQERF 293
+V + S +++ + R + P P A SI ++R+
Sbjct: 222 TIVTPGYIESELTQGKYFSGEGELIVNQDMRDVQVGPFPVASASGCAKSIVNGVCRKQRY 281
Query: 294 ATSTPYWSHALY 305
T P W Y
Sbjct: 282 VTE-PSWFKVTY 292
>At5g50130 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 332
Score = 54.7 bits (130), Expect = 2e-07
Identities = 46/174 (26%), Positives = 83/174 (47%), Gaps = 16/174 (9%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKE--IETECKIDVKILAIDVSS 126
++TG + GIG E A+ LAKRG +++ R + K E+ KE I + D+ + ID+SS
Sbjct: 40 IITGGTSGIGAETARVLAKRGVRVVMAVR-DMKKAEMVKERIIRENPEADIILFEIDLSS 98
Query: 127 DSKENYTLIREVASGLPVTVLINNVGKSHSIPVPFDQTEESELRDIITINNTATLMITQT 186
S + ++ LP+ +LINN G + P + E ++ N ++T+
Sbjct: 99 LSSVARFCSQFLSQDLPLNILINNAG----VFSPNLEFSEEKIELTFATNFLGHYLLTEM 154
Query: 187 LLPQLKASVKTLKCRGLILTMGS--FGGLLPTPFL-------ATYSGSKAFLQS 231
L+ ++ + + G I+ + S + P F Y+G++A+ QS
Sbjct: 155 LIEKMIDTAEKSGIEGRIINLSSVIHNWVKPDCFSFPKLLHPIRYNGTRAYAQS 208
>At5g06060 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 264
Score = 54.3 bits (129), Expect = 3e-07
Identities = 54/199 (27%), Positives = 89/199 (44%), Gaps = 23/199 (11%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIETECKIDVKILAIDVS--- 125
+VTG + GIG+ ++LAK G + SR + +L C D K + VS
Sbjct: 15 LVTGGTRGIGRAVVEELAKFGAKVHTCSRNQEEL--------NACLNDWKANGLVVSGSV 66
Query: 126 ---SDSKENYTLIREVASGL--PVTVLINNVGKSHSIPVPFDQTEESELRDIITINNTAT 180
S + LI+E +S + +LINNVG ++ P + E I++ N +
Sbjct: 67 CDASVRDQREKLIQEASSAFSGKLNILINNVGT--NVRKPTVEYSSEEYAKIMSTNLESA 124
Query: 181 LMITQTLLPQLKASVKTLKCRGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSNALAGEL 240
++Q P LKAS G I+ + S GL+ + Y +K L + LA E
Sbjct: 125 FHLSQIAHPLLKASGV-----GSIVFISSVAGLVHLSSGSIYGATKGALNQLTRNLACEW 179
Query: 241 SSDSIDVELVLSYLVTSAM 259
+SD+I V + + +++
Sbjct: 180 ASDNIRTNCVAPWYIKTSL 198
>7301303 [Q] KOG1210 Predicted 3-ketosphinganine reductase
Length = 336
Score = 54.3 bits (129), Expect = 3e-07
Identities = 47/187 (25%), Positives = 85/187 (45%), Gaps = 11/187 (5%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLILISRTESKL---VELKKEIETECKIDVKILAIDVS 125
VVTG S GIG A + A +G N+ +I+R E L V L + I + ++D+S
Sbjct: 39 VVTGGSKGIGLCLAVECAMKGANVTVIARDEKMLSGAVALMEVIRQRPDQKFQYRSLDIS 98
Query: 126 SDSKENYTLIREVASGL-PVTVLINNVGKSHSIPVPFDQTEESELRDIITINNTATLMIT 184
D + ++ E+ P+ LIN G +I F++ ++ ++ +N T T
Sbjct: 99 GDYDQVAKVLGEIEDSFGPIYTLINCAGM--AICGVFEEVSVQDVHKLMNVNFFGTYNCT 156
Query: 185 QTLLPQLKASVKTLKCRGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSNALAGELSSDS 244
+ +LP++K + G+I+ S + YS +K L++ + +A E
Sbjct: 157 RYVLPKMKKAGD-----GIIVITASQAAMFGIYGYGPYSATKYALRAMAETIAMESREHG 211
Query: 245 IDVELVL 251
+ V L +
Sbjct: 212 VSVTLAM 218
>SPAC23D3.11 [Q] KOG1209 1-Acyl dihydroxyacetone phosphate reductase and related
dehydrogenases
Length = 296
Score = 53.9 bits (128), Expect = 3e-07
Identities = 50/187 (26%), Positives = 88/187 (46%), Gaps = 19/187 (10%)
Query: 69 VVTGASDG-IGKEYAKQLAKRGFNLILISRTESKLVELKKEIETECKIDVKILAIDVSSD 127
++TG S+G IG A + + GF ++ +R ++ L K K+DV D
Sbjct: 8 LITGCSEGGIGNALALKFHQEGFQVLATARQVERMDNLTKAGLQTLKLDV------TDED 61
Query: 128 S-KENYTLIREVASGLPVTVLINNVGKSHSIP-VPFDQTEESELRDIITINNTATLMITQ 185
S +E +R+ +G + LINN G S P + D + S++ D+ N + + +
Sbjct: 62 SVREVEQEVRKFTNG-SLHYLINNAGAPCSAPAIDLDIEDVSKVMDV---NFYGVIRMNK 117
Query: 186 TLLPQLKASVKTLKCRGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSNALAGELSSDSI 245
QL ++ +G I+ + S +P F A Y+ SKA L ++SN L EL+ +
Sbjct: 118 AFQHQL------IRAKGTIVNVNSLVSYVPFAFNAAYNASKAALLAYSNTLRIELAPFGV 171
Query: 246 DVELVLS 252
V +++
Sbjct: 172 QVTSIMT 178
>At1g64590 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 334
Score = 53.9 bits (128), Expect = 3e-07
Identities = 41/143 (28%), Positives = 72/143 (49%), Gaps = 7/143 (4%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIETEC-KIDVKILAIDVSSD 127
++TGA+ GIG E A+ LAKRG L+L +R+ E K I +E ++ ++ +D+SS
Sbjct: 38 IITGATSGIGAETARVLAKRGARLVLPARSVKTAEETKARILSEFPDAEIIVMHLDLSSL 97
Query: 128 SKENYTLIREVASGLPVTVLINNVGK-SHSIPVPFDQTEESELRDIITINNTATLMITQT 186
+ + + LP+ +LINN GK +H + D E + N ++T+
Sbjct: 98 TSVRRFVDDFESLNLPLNILINNAGKYAHKHALSEDGVEMT-----FATNYLGHFLLTKL 152
Query: 187 LLPQLKASVKTLKCRGLILTMGS 209
LL ++ + +G I+ + S
Sbjct: 153 LLKKMIETAAQTGVQGRIVNVTS 175
>Hs20475206 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 305
Score = 53.5 bits (127), Expect = 4e-07
Identities = 49/177 (27%), Positives = 80/177 (44%), Gaps = 14/177 (7%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIETEC-KIDVKILAIDVS-S 126
++TGA GIG++ + AKR L+L + + +E EC K+ V A V S
Sbjct: 40 LITGAGHGIGRQTTYEFAKRQSILVLWDINKRGV----EETAAECRKLGVTAHAYVVDCS 95
Query: 127 DSKENYTLIREVASGL-PVTVLINNVGKSHSIPVPFDQTEESELRDIITINNTATLMITQ 185
+ +E Y + +V + VT+++NN G + P T++ E+ +N IT+
Sbjct: 96 NREEIYRSLNQVKKEVGDVTIVVNNAGTVY--PADLLSTKDEEITKTFEVNILGHFWITK 153
Query: 186 TLLPQLKASVKTLKCRGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSNALAGELSS 242
LLP + + G I+T+ S G P+L Y SK + L EL +
Sbjct: 154 ALLPSMME-----RNHGHIVTVASVCGHEGIPYLIPYCSSKFAAVGFHRGLTSELQA 205
>CE15574 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 279
Score = 53.5 bits (127), Expect = 4e-07
Identities = 53/196 (27%), Positives = 92/196 (46%), Gaps = 29/196 (14%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIETECKIDVKILAI--DVSS 126
+VTG+S+GIG+ A LA+ G + + R +L E K+EI + +L+I D+++
Sbjct: 10 LVTGSSNGIGRATAILLAREGAKVTITGRNAQRLEETKQEILRSGVPEDHVLSIIADLAT 69
Query: 127 DSKE----NYTL-------IREVASGLPVTVLINNVGKSHSIPVPFDQTEESELRDIITI 175
+S + N T+ I +G +T L ++G ++ V FD+T LR ++T+
Sbjct: 70 ESGQIELMNSTVDIFGRLDILVNNAGAAITDLEGHIGVGTNVSV-FDKTMRINLRSVVTL 128
Query: 176 NNTATLMITQTLLPQLKASVKTLKCRGLILTMGSF-GGLLPTPFLATYSGSKAFLQSWSN 234
KA +K +G I+ + S GG P L Y+ SK+ L ++
Sbjct: 129 TQ--------------KAKEHLIKTKGEIVNVSSIAGGQHAQPELIYYAMSKSALDQYTR 174
Query: 235 ALAGELSSDSIDVELV 250
+ A +L + V V
Sbjct: 175 SAAIDLIQHGVRVNSV 190
>CE05752 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 284
Score = 53.5 bits (127), Expect = 4e-07
Identities = 48/202 (23%), Positives = 90/202 (43%), Gaps = 13/202 (6%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIETECKIDVKILAI--DVSS 126
++TG+S+GIG+ A+ LA G + + R +L E K + + +L + D++
Sbjct: 10 IITGSSNGIGQATARLLASEGAKVTVTGRNAERLEETKNILLGAGVPEGNVLVVVGDITQ 69
Query: 127 DSKENYTLIREVASGLPVTVLINNVGKSHSIPVPFDQTEESELRDIITINNTATLMITQT 186
+S + + + + +L+NN G +P Q + + I T + T L +
Sbjct: 70 ESVQENLIKSTLDKFGKIDILVNNAGAG----IPDAQGKSGVNQSIDTYHKTFELNVQSV 125
Query: 187 LLPQLKASVKTLKCRGLILTMGSFG----GLLPTPFLATYSGSKAFLQSWSNALAGELSS 242
+ KA K +G I+ + S G + +P+ YS +KA L ++ A +L
Sbjct: 126 IEMTQKARPHLAKTQGEIVNISSIGAGPAAQVASPY---YSIAKAALDQYTRTAAIDLVP 182
Query: 243 DSIDVELVLSYLVTSAMSKIRR 264
+ I V V V++ S + R
Sbjct: 183 EGIRVNSVSPGAVSTGFSAVSR 204
>7290936 [Q] KOG1204 Predicted dehydrogenase
Length = 261
Score = 53.5 bits (127), Expect = 4e-07
Identities = 51/194 (26%), Positives = 92/194 (47%), Gaps = 18/194 (9%)
Query: 69 VVTGASDGIGKEYAKQLAKR----GFNLILISRTESKLVELKKEI-ETECKIDVKILAID 123
+VTGAS GIG+E+A+QLAKR G + L+ R ++ L E K EI T + V+ +++
Sbjct: 10 LVTGASRGIGREFAQQLAKRIKAEGSMVTLLGRNQTLLQESKAEIVATVPDLSVQTYSLE 69
Query: 124 VSSDSKENYTLIREVASG---LPVTVLINNVGKSHSIPVPFDQTEESE-LRDIITINNTA 179
+ + E++T I E + G ++I+N G + +++ L+ N +
Sbjct: 70 LETAKTEDFTKILEASGGKNNFERAIVIHNAGTVGDTSKRAKEIGDTDFLQRYYHSNVFS 129
Query: 180 TLMITQTLLPQLKASVKTLKCRGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSNALAGE 239
+ + + K K L++ + + + P +A Y KA + + LA E
Sbjct: 130 AISLNCEFMRVFKGIPK------LVVNLSTLAAIAPISSMAHYCTVKAAREMYFRVLATE 183
Query: 240 LSSDSIDVELVLSY 253
+S + LVL+Y
Sbjct: 184 ---ESAEDTLVLNY 194
>SPCC1450.15_1 [Q] KOG1210 Predicted 3-ketosphinganine reductase
Length = 373
Score = 53.5 bits (127), Expect = 4e-07
Identities = 52/195 (26%), Positives = 93/195 (47%), Gaps = 16/195 (8%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIETECKI----DVKILAIDV 124
+VTG S G+GK AK+L RG N+ +++RT +KL E E+ ++ KI V ++D+
Sbjct: 26 LVTGGSQGLGKAIAKELVLRGANVTIVARTVTKLQEAVAEL-SDSKIHEDQQVSFESVDL 84
Query: 125 SSDSKENYTLIREVASGLPVTV--LINNVGKSHSIPVPFDQTEESELRDIITINNTATLM 182
+S Y + + LP +++ G IP F + + S + N A++
Sbjct: 85 TS-----YESVHSMIERLPFCPDHVVHCAGS--CIPGFFTELDPSVFEKQMRQNYLASVY 137
Query: 183 ITQTLLPQLKASVKTLKCRGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSNALAGELSS 242
+ + ++K + R IL +GS LP + YS KA +++ +++L E
Sbjct: 138 VCHAAIRRMKEISPSYSRR--ILLVGSLLSSLPIIGYSAYSPVKAAVRNLADSLRQECIL 195
Query: 243 DSIDVELVLSYLVTS 257
I+V + L + S
Sbjct: 196 YDIEVSVYLPSTILS 210
>Hs20070272 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 318
Score = 53.1 bits (126), Expect = 6e-07
Identities = 48/132 (36%), Positives = 68/132 (51%), Gaps = 15/132 (11%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIETEC-KIDVKILAIDVSSD 127
VVTGA+ GIGKE AK+LA+RG + L R K + KEI+T V + +D+ SD
Sbjct: 45 VVTGANTGIGKETAKELAQRGARVYLACRDVEKGELVAKEIQTTTGNQQVLVRKLDL-SD 103
Query: 128 SKENYTLIREVASGL-----PVTVLINNVGKSHSIPVPFDQTEESELRDIITINNTATLM 182
+K IR A G + VLINN G + P+ +T + I +N+ +
Sbjct: 104 TKS----IRAFAKGFLAEEKHLHVLINNAG---VMMCPYSKTADG-FEMHIGVNHLGHFL 155
Query: 183 ITQTLLPQLKAS 194
+T LL +LK S
Sbjct: 156 LTHLLLEKLKES 167
>At1g63380 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 287
Score = 53.1 bits (126), Expect = 6e-07
Identities = 54/199 (27%), Positives = 96/199 (48%), Gaps = 12/199 (6%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIETECKIDVKILA--IDVSS 126
+VTGAS GIG+E L K G ++ +R +L L EI + I V+ +A +DVSS
Sbjct: 28 LVTGASSGIGREICLDLCKAGCKIVAAARRVDRLNSLCSEINSFGAIGVQAVALELDVSS 87
Query: 127 DSKENYTLIREVASGL-PVTVLINNVGKSHSIPVPFDQTEESELRDIITINNTATLMITQ 185
++ ++E + VLINN G ++ D +EE E + N T + +I++
Sbjct: 88 EADTIRKAVKEAWETFGKIDVLINNAGIRGNVKSSLDLSEE-EWDKVFRTNLTGSWLISK 146
Query: 186 TLLPQLKASVKTLKCRGLILTMGSFGGL---LPTPFLATYSGSKAFLQSWSNALAGELSS 242
+ ++ + + G ++ + S GL L LA Y+ SK + + + +A EL+
Sbjct: 147 YVCLLMRDAER----GGSVINVSSISGLHRGLLRGGLA-YACSKGGVDTMTRMMAIELAV 201
Query: 243 DSIDVELVLSYLVTSAMSK 261
I V + + S +++
Sbjct: 202 YKIRVNSIAPGIFRSEITQ 220
>7296704 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 264
Score = 53.1 bits (126), Expect = 6e-07
Identities = 54/212 (25%), Positives = 89/212 (41%), Gaps = 46/212 (21%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLILISRTESKLV------------------ELKKEIE 110
++TGA+ GIG A+ +K G L L+ R E L+ +L K E
Sbjct: 17 LITGAASGIGAAAAEMFSKLGACLALVDREEEGLICVMKRCMKMGHEPYGIAGDLLKPPE 76
Query: 111 TECKIDVKILAIDVSSDSKENYTLIREVASGLPVTVLINNVGKSHSIPV-PFDQTEESEL 169
EC ++ + E Y + VL+N G +P TE +
Sbjct: 77 IEC----------IARKTTERYEG--------KLDVLVNGAG---IMPTGTLQSTELACF 115
Query: 170 RDIITINNTATLMITQTLLPQLKASVKTLKCRGLILTMGSFGGLLPTPFLATYSGSKAFL 229
++ N + +T+ LLPQL L+C+G I+ + S GL P L Y+ SKA +
Sbjct: 116 THVMEANVRSGFYLTKLLLPQL------LQCKGSIVNVSSVCGLRAFPNLVAYNMSKAAV 169
Query: 230 QSWSNALAGELSSDSIDVELVLSYLVTSAMSK 261
++ +LA +L + V V ++ + + K
Sbjct: 170 DQFTRSLALDLGPQGVRVNAVNPGVIRTNLQK 201
>CE03925_2 [I] KOG1014 17 beta-hydroxysteroid dehydrogenase type 3 HSD17B3
Length = 321
Score = 53.1 bits (126), Expect = 6e-07
Identities = 49/171 (28%), Positives = 76/171 (43%), Gaps = 13/171 (7%)
Query: 44 KMVLDLFVLPGPDFXXXXXXXXXXXVVTGASDGIGKEYAKQLAK-RGF-NLILISRTESK 101
K VL F+ P D V+TG +DGIGK Y ++L K RG LI R K
Sbjct: 30 KSVLVHFITPKHDLDYLKDTWT---VITGGTDGIGKAYIEELCKTRGLKKFYLIGRNIDK 86
Query: 102 LVELKKEIETECKIDVKILAIDVSSDSKENYTLIREVASGLPVTVLINNVGKSHSIPVPF 161
L KKE+ + +V V K++ + + + L V +LIN G + I
Sbjct: 87 LNNTKKELVEQHGCEV---MCHVHDFEKDDLSALPKDLETLDVGILINCAGIAPHIIGTL 143
Query: 162 DQTEESELRDIITINNTATLMITQTLLPQLKASVKTLKCRGLILTMGSFGG 212
+ E I+ +N + + +T+ +LP + K RG+I+ + S G
Sbjct: 144 TELPEGLASKILRVNLMSAVKMTEMILPNM-----VKKKRGIIVNISSMTG 189
>SPAC977.08 [Q] KOG1205 Predicted dehydrogenase
Length = 236
Score = 52.8 bits (125), Expect = 7e-07
Identities = 32/135 (23%), Positives = 68/135 (49%), Gaps = 7/135 (5%)
Query: 116 DVKILAIDVSSDSKENYTLIREVASGLPVTVLINNVGKSHSIPVPFDQTEESELRDIITI 175
+V + +DV++ S ++ + ++ + VL+NN G +S+ P + T E ++ +I
Sbjct: 15 NVLVTQLDVNNFSSIKKSVEKAISHFGRIDVLLNNAG--YSVYSPLESTTEEQIHNIFNT 72
Query: 176 NNTATLMITQTLLPQLKASVKTLKCRGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSNA 235
N L + + + P ++ + G+I+ + S GG + P Y G+K ++ S A
Sbjct: 73 NVFGALEVIKAITPIFRS-----QHNGMIINVSSIGGKMTFPLGCLYYGTKYAIEGISEA 127
Query: 236 LAGELSSDSIDVELV 250
L E+ S + V+++
Sbjct: 128 LTWEMQSIGVKVKII 142
>SPAC1348.09 [Q] KOG1205 Predicted dehydrogenase
Length = 236
Score = 52.8 bits (125), Expect = 7e-07
Identities = 32/135 (23%), Positives = 68/135 (49%), Gaps = 7/135 (5%)
Query: 116 DVKILAIDVSSDSKENYTLIREVASGLPVTVLINNVGKSHSIPVPFDQTEESELRDIITI 175
+V + +DV++ S ++ + ++ + VL+NN G +S+ P + T E ++ +I
Sbjct: 15 NVLVTQLDVNNFSSIKKSVEKAISHFGRIDVLLNNAG--YSVYSPLESTTEEQIHNIFNT 72
Query: 176 NNTATLMITQTLLPQLKASVKTLKCRGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSNA 235
N L + + + P ++ + G+I+ + S GG + P Y G+K ++ S A
Sbjct: 73 NVFGALEVIKAITPIFRS-----QHNGMIINVSSIGGKMTFPLGCLYYGTKYAIEGISEA 127
Query: 236 LAGELSSDSIDVELV 250
L E+ S + V+++
Sbjct: 128 LTWEMQSIGVKVKII 142
>Hs7705905 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 300
Score = 52.8 bits (125), Expect = 7e-07
Identities = 46/177 (25%), Positives = 83/177 (45%), Gaps = 14/177 (7%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIETECK-IDVKILAIDVSSD 127
++TGA GIG+ A + AK L+L + L +E +CK + K+ V
Sbjct: 40 LITGAGHGIGRLTAYEFAKLKSKLVLWDINKHGL----EETAAKCKGLGAKVHTFVVDCS 95
Query: 128 SKEN-YTLIREVASGL-PVTVLINNVGKSHSIPVPFDQTEESELRDIITINNTATLMITQ 185
++E+ Y+ ++V + + V++L+NN G ++ + T++ ++ +N A T+
Sbjct: 96 NREDIYSSAKKVKAEIGDVSILVNNAGVVYTSDL--FATQDPQIEKTFEVNVLAHFWTTK 153
Query: 186 TLLPQLKASVKTLKCRGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSNALAGELSS 242
LP + T G I+T+ S G + PFL Y SK + L EL++
Sbjct: 154 AFLPAM-----TKNNHGHIVTVASAAGHVSVPFLLAYCSSKFAAVGFHKTLTDELAA 205
>Hs21553325 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 330
Score = 52.8 bits (125), Expect = 7e-07
Identities = 39/127 (30%), Positives = 65/127 (50%), Gaps = 5/127 (3%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIETECKID-VKILAIDVSSD 127
+VTG +DGIG AK LA+ G ++I+ +SK ++ +I+ E D V+ L D++S
Sbjct: 47 IVTGGTDGIGYSTAKHLARLGMHVIIAGNNDSKAKQVVSKIKEETLNDKVEFLYCDLASM 106
Query: 128 SKENYTLIREVASGLPVTVLINNVGKSHSIPVPFDQTEESELRDIITINNTATLMITQTL 187
+ + + +P+ VLINN G + VP +T + + +N ++T L
Sbjct: 107 TSIRQFVQKFKMKKIPLHVLINNAG---VMMVPQRKTRDG-FEEHFGLNYLGHFLLTNLL 162
Query: 188 LPQLKAS 194
L LK S
Sbjct: 163 LDTLKES 169
>CE21095 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 280
Score = 52.8 bits (125), Expect = 7e-07
Identities = 50/199 (25%), Positives = 94/199 (47%), Gaps = 15/199 (7%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEI--ETECKIDVKILAIDVSS 126
++TG+S+GIG+ A A+ G N+ + R+ +L E ++ I + V + DV++
Sbjct: 10 IITGSSNGIGRTTAILFAQEGANVTITGRSSERLEETRQIILKSGVSEKQVNSVVADVTT 69
Query: 127 DSKENYTLIREVASGLPVTVLINNVGKSHSIPVPFDQTEESELRDI----ITINNTATLM 182
+ ++ + + + VL+NN G +IP F T + DI + +N A +
Sbjct: 70 EDGQDQIINSTLKQFGKIDVLVNNAGA--AIPDAFGTTGTDQGIDIYHKTLKLNLQAVIE 127
Query: 183 ITQTLLPQLKASVKTLKCRGLILTMGSF-GGLLPTPFLATYSGSKAFLQSWSNALAGELS 241
+T+ + P L AS +G I+ + S G P Y+ +KA L ++ + A +L+
Sbjct: 128 MTKKVKPHLVAS------KGEIVNVSSIVAGPQAQPDFLYYAIAKAALDQYTRSTAIDLA 181
Query: 242 SDSIDVELVLSYLVTSAMS 260
I V V +V + +
Sbjct: 182 KFGIRVNSVSPGMVETGFT 200
>At2g30670 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 262
Score = 52.8 bits (125), Expect = 7e-07
Identities = 55/195 (28%), Positives = 91/195 (46%), Gaps = 11/195 (5%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIETECKIDVKILAIDVSSDS 128
+VTG + GIG ++LA G + + +E+ L + E E + V DVSS S
Sbjct: 13 LVTGGASGIGHAIVEELAGLGARIYVCDISETLLNQSLSEWEKK-GFQVSGSICDVSSHS 71
Query: 129 KENYTLIREVASGL--PVTVLINNVGKSHSIPVPFDQTEESELRDIITINNTATLMITQT 186
E TL++ V+ + +L+NNVG + P P + ++ I+ N + ++Q
Sbjct: 72 -ERETLMQTVSKMFDGKLNILVNNVGVVN--PKPTIEYVAADFSFSISTNLESAYHLSQL 128
Query: 187 LLPQLKASVKTLKCRGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSNALAGELSSDSID 246
P LKAS G I+ + S GG++ + YS +K L + LA E + D I
Sbjct: 129 SHPLLKASE-----FGSIIFISSVGGVVSMECGSIYSLTKGALNQLAKTLACEWARDGIR 183
Query: 247 VELVLSYLVTSAMSK 261
V + +AM++
Sbjct: 184 ANSVAPNFIYTAMAQ 198
>At1g62610 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 307
Score = 52.4 bits (124), Expect = 1e-06
Identities = 55/199 (27%), Positives = 94/199 (46%), Gaps = 12/199 (6%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIETECKIDVK--ILAIDVSS 126
+VTGAS GIG+E L K G ++ +R +L L EI + I V+ L +DVSS
Sbjct: 50 LVTGASSGIGREICLDLCKAGCKIVAAARRVDRLNSLCSEINSFGAIGVQAAALELDVSS 109
Query: 127 DSKENYTLIREVASGL-PVTVLINNVGKSHSIPVPFDQTEESELRDIITINNTATLMITQ 185
D+ ++E + VLINN G ++ D ++E E + N T + +I++
Sbjct: 110 DADTIRKAVKEAWEIFGTIDVLINNAGIRGNVKSSLDLSKE-EWDKVFRTNLTGSWLISK 168
Query: 186 TLLPQLKASVKTLKCRGLILTMGSFGGL---LPTPFLATYSGSKAFLQSWSNALAGELSS 242
+ ++ K G ++ + S GL L LA Y+ SK + + + +A EL+
Sbjct: 169 YVC----LLMRDAKRGGSVINVSSISGLHRGLLRGGLA-YACSKGGVDTMTRMMAIELAV 223
Query: 243 DSIDVELVLSYLVTSAMSK 261
I V + + S +++
Sbjct: 224 YKIRVNSIAPGIFRSEITQ 242
>CE26900 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 305
Score = 52.0 bits (123), Expect = 1e-06
Identities = 58/239 (24%), Positives = 100/239 (41%), Gaps = 25/239 (10%)
Query: 26 IVFGLGISKMVFLTLNFSKMVLDLFVLPGPDFXXXXXXXXXXXVVTGASDGIGKEYAKQL 85
++F L I ++ L K L +LP D ++TGA +G+GK A++
Sbjct: 11 LLFNLLIQNLISLI----KYALPYSLLPKKDLYRKKV------LITGAGNGLGKLLAQKF 60
Query: 86 AKRGFNLILISRTESKLVELKKEIETEC--KIDVKILAIDVSSDSKENYTLIREVASGLP 143
A RG LIL + ELK EI ++ D ++ +I ++
Sbjct: 61 AARGATLILWDINLQSVDELKNEIRGNQGEAHSYEVNLCDPGKIAQVGQQVINDIGK--- 117
Query: 144 VTVLINNVGKSHSIPVPFDQTEESELRDIITINNTATLMITQTLLPQLKASVKTLKCRGL 203
V +L+NN G + + + + E+E+ +N A Q LP + G
Sbjct: 118 VDILVNNAGIATAKMIL--DSSENEINRSFDVNVKAHFYTVQQFLPAMLKD-----NNGH 170
Query: 204 ILTMGSFGGLLPTPFLATYSGSKAFLQSWSNALAGEL---SSDSIDVELVLSYLVTSAM 259
I+T+ S G + + LA YS +K + ++L E+ + + LV Y V ++M
Sbjct: 171 IVTIASAAGKMGSSGLADYSSTKHAAVGFHDSLVAEIMESEKNGVKTTLVCPYYVHTSM 229
>CE23899 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 279
Score = 52.0 bits (123), Expect = 1e-06
Identities = 49/188 (26%), Positives = 91/188 (48%), Gaps = 13/188 (6%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIETECKIDVKILAI--DVSS 126
+VTG+S+GIG+ A LA+ G + + R +L E ++EI + +L+I D+++
Sbjct: 10 LVTGSSNGIGRATAVLLAQEGAKVTITGRNADRLEETRQEILKSGVPEDHVLSIATDLAT 69
Query: 127 DSKENYTLIREVASGLPVTVLINNVGKSHSIP---VPFDQTEESELRDIITINNTATLMI 183
+ ++ + + + +L+NN G + + V DQ + S I+ IN + + +
Sbjct: 70 EKGQDELVNSTIQKFGRLDILVNNAGAAFNDDQGRVGVDQ-DVSVYDRIMQINMRSVVTL 128
Query: 184 TQTLLPQLKASVKTLKCRGLILTMGSFG-GLLPTPFLATYSGSKAFLQSWSNALAGELSS 242
TQ KA +K +G ++ + S G G P Y+ SKA L ++ + A +L
Sbjct: 129 TQ------KAKEHLVKAKGEVVNVSSIGAGPQAQPTFMYYAMSKAALDQYTRSAAIDLIQ 182
Query: 243 DSIDVELV 250
+ V V
Sbjct: 183 YGVRVNSV 190
>7300387 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 317
Score = 52.0 bits (123), Expect = 1e-06
Identities = 42/131 (32%), Positives = 66/131 (50%), Gaps = 12/131 (9%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIETECKIDVKILAIDVSSDS 128
++TGA+ GIGKE AK LA RG +I+ R +K EI E K + KIL + S
Sbjct: 37 IITGANSGIGKETAKDLAGRGARIIMACRNLETANAVKDEIVKETK-NNKILVKKLDLGS 95
Query: 129 KENYTLIREVASGL-----PVTVLINNVGKSHSIPVPFDQTEESELRDIITINNTATLMI 183
+++ +RE A+ + + VLI+N G + + QT E + + N+ ++
Sbjct: 96 QKS---VREFAADIVKTEPKIDVLIHNAGMALAFR---GQTSEDGVELTMATNHYGPFLL 149
Query: 184 TQTLLPQLKAS 194
T L+ LK S
Sbjct: 150 THLLIDVLKKS 160
>Hs4504501_1 [Q] KOG1205 Predicted dehydrogenase
Length = 244
Score = 52.0 bits (123), Expect = 1e-06
Identities = 52/188 (27%), Positives = 82/188 (42%), Gaps = 16/188 (8%)
Query: 69 VVTGASDGIGKEYAKQLAK---RGFNLILISR---TESKLVELKKEIETECKIDVKILAI 122
++TG S GIG A +LA + F + R T+ +L E + + ++ L +
Sbjct: 7 LITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPG-SLETLQL 65
Query: 123 DVSSDSKENYTLIREVASGLPVTVLINNVGKSHSIPVPFDQTEESELRDIITINNTATLM 182
DV DSK V G V VL+ N G + P + E + ++ +N T+
Sbjct: 66 DVR-DSKSVAAARERVTEGR-VDVLVCNAGLG--LLGPLEALGEDAVASVLDVNVVGTVR 121
Query: 183 ITQTLLPQLKASVKTLKCRGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSNALAGELSS 242
+ Q LP +K + G +L GS GGL+ PF Y SK L+ +LA L
Sbjct: 122 MLQAFLPDMKR-----RGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLP 176
Query: 243 DSIDVELV 250
+ + L+
Sbjct: 177 FGVHLSLI 184
>CE02490_1 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 302
Score = 52.0 bits (123), Expect = 1e-06
Identities = 41/134 (30%), Positives = 70/134 (51%), Gaps = 14/134 (10%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIETEC----KIDVKIL--AI 122
++TGAS GIGKE A +LAK G N+++ ++T + +L I + K K L +
Sbjct: 13 LITGASRGIGKEIALKLAKDGANIVVAAKTATAHPKLPGTIYSAAEEIEKAGGKALPCIV 72
Query: 123 DVSSDSKENYTLIREVASGLPVTVLINNVGKSHSIPVPFDQTEESELR--DII-TINNTA 179
DV ++ ++ V + +LINN + TE +E++ D++ +IN
Sbjct: 73 DVRDEASVKASVEEAVKKFGGIDILINNAS-----AISLTDTENTEMKRYDLMHSINTRG 127
Query: 180 TLMITQTLLPQLKA 193
T ++T+T LP LK+
Sbjct: 128 TFLMTKTCLPYLKS 141
>HsM4506571 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 317
Score = 51.6 bits (122), Expect = 2e-06
Identities = 49/196 (25%), Positives = 91/196 (46%), Gaps = 13/196 (6%)
Query: 70 VTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIETECKIDVKILAIDVSSDSK 129
+TG G GK A+QL RG ++ TE +L+ +T +++ L + +
Sbjct: 34 ITGCDSGFGKLLARQLDARGLRVLAACLTEKGAEQLRG--QTSDRLETVTLDVTKTESVA 91
Query: 130 ENYTLIREVASGLPVTVLINNVGKSHSIP-VPFDQTEESELRDIITINNTATLMITQTLL 188
++E + L+NN G S+P P + + + I+ +N + +T +LL
Sbjct: 92 AAAQWVKECVRDKGLWGLVNNAG--ISLPTAPNELLTKQDFVTILDVNLLGVIDVTLSLL 149
Query: 189 PQLKASVKTLKCRGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSNALAGELSSDSIDVE 248
P ++ K RG ++ + S G + + F Y SK ++++S++L ELS + V
Sbjct: 150 PLVR------KARGRVVNVSSVMGRV-SLFGGGYCISKYGVEAFSDSLRRELSYFGVKVA 202
Query: 249 LV-LSYLVTSAMSKIR 263
++ Y T+ SK R
Sbjct: 203 MIEPGYFKTAVTSKER 218
>Hs17455069 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 313
Score = 51.6 bits (122), Expect = 2e-06
Identities = 42/172 (24%), Positives = 78/172 (44%), Gaps = 12/172 (6%)
Query: 70 VTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIETECKIDVKILAIDVSSDSK 129
+TG G G AKQL RG ++ TE +L++ +T ++ +L + S K
Sbjct: 30 ITGCDSGFGNLLAKQLVDRGMQVLAACFTEEGSQKLQR--DTSYRLQTTLLDVTKSESIK 87
Query: 130 ENYTLIREVASGLPVTVLINNVGKSHSIPV-PFDQTEESELRDIITINNTATLMITQTLL 188
+R+ + L+NN G +P P + + + +I +N + +T +L
Sbjct: 88 AAAQWVRDKVGEQGLWALVNNAGV--GLPSGPNEWLTKDDFVKVINVNLVGLIEVTLHML 145
Query: 189 PQLKASVKTLKCRGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSNALAGEL 240
P +K + RG ++ M S GG + Y SK ++++S+++ EL
Sbjct: 146 PMVK------RARGRVVNMSSSGGRVAV-IGGGYCVSKFGVEAFSDSIRREL 190
>Hs14735093 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 319
Score = 51.6 bits (122), Expect = 2e-06
Identities = 43/181 (23%), Positives = 80/181 (43%), Gaps = 10/181 (5%)
Query: 70 VTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIETECKIDVKILAIDVSSDSK 129
+TG G G A+ K+GF++I TES LK ET ++ +L + + K
Sbjct: 34 ITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALK--AETSERLRTVLLDVTDPENVK 91
Query: 130 ENYTLIREVASGLPVTVLINNVGKSHSIPVPFDQTEESELRDIITINNTATLMITQTLLP 189
++ + LINN G + P D + R+ I +N + +T +LP
Sbjct: 92 RTAQWVKNQVGEKGLWGLINNAGVP-GVLAPTDWLTLEDYREPIEVNLFGLISVTLNMLP 150
Query: 190 QLKASVKTLKCRGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSNALAGELSSDSIDVEL 249
+K K +G ++ + S GG L Y+ SK ++ ++++L ++ + + V
Sbjct: 151 LVK------KAQGRVINVSSVGGRLAI-VGGGYTPSKYAVEGFNDSLRRDMKAFGVHVSC 203
Query: 250 V 250
+
Sbjct: 204 I 204
>At5g50770 [Q] KOG1205 Predicted dehydrogenase
Length = 342
Score = 51.6 bits (122), Expect = 2e-06
Identities = 57/195 (29%), Positives = 85/195 (43%), Gaps = 12/195 (6%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIETECKIDVKILAIDVSSDS 128
V+TGA+ GIG+ A + KRG L L+ L + E +V L DVS
Sbjct: 51 VITGAASGIGEALAYEYGKRGAYLALVDIRGEPLFHVAALAELYGSPEVLPLVADVSKLQ 110
Query: 129 KENYTLIREVASGLPVTVLINNVGKSHSIPVPF--DQTEESELRDIITINNTATLMITQT 186
+ V + L+ N G + P+ F D + S+ + IN ++ T
Sbjct: 111 DCERFIRATVLHFGRLDHLVTNAGVA---PLYFFADIEDVSKASPAMDINFWGSVYCTFF 167
Query: 187 LLPQLKASVKTLKCRGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSNALAGELSSDSID 246
P LK K RG I+ + S G + +P L+ Y SKA + ++ L E SD I
Sbjct: 168 ASPYLK------KFRGRIVVIASGCGYIASPRLSFYCASKAAVIAFYETLRTEFGSD-IG 220
Query: 247 VELVLSYLVTSAMSK 261
V +V +V S MS+
Sbjct: 221 VTIVAPGIVDSEMSR 235
>At1g24360 [I] KOG1200 Mitochondrial/plastidial beta-ketoacyl-ACP reductase
Length = 308
Score = 51.6 bits (122), Expect = 2e-06
Identities = 50/193 (25%), Positives = 89/193 (45%), Gaps = 20/193 (10%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLIL-ISRTESKLVELKKEIETECKIDVKILAIDVSSD 127
V+TGAS GIGK A L K G +++ +R+ + E+ K+IE E DVS
Sbjct: 80 VITGASRGIGKAIALALGKAGCKVLVNYARSAKEAEEVAKQIE-EYGGQAITFGGDVSKA 138
Query: 128 SKENYTLIREVASGLPVTVLINNVGKSHSIPVPFDQTEESELRDIITINNTATLMITQTL 187
+ + + + + V++NN G + + + ++S+ ++I +N T + TQ
Sbjct: 139 TDVDAMMKTALDKWGTIDVVVNNAGITRDTLLI--RMKQSQWDEVIALNLTGVFLCTQ-- 194
Query: 188 LPQLKASVKTLKCRGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSNALAGELSSDSIDV 247
G I+ + S GL+ A Y+ +K + S+S A E +S +I+V
Sbjct: 195 --------------GRIINISSVVGLIGNIGQANYAAAKGGVISFSKTAAREGASRNINV 240
Query: 248 ELVLSYLVTSAMS 260
+V + S M+
Sbjct: 241 NVVCPGFIASDMT 253
>At2g29360 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 271
Score = 51.2 bits (121), Expect = 2e-06
Identities = 50/193 (25%), Positives = 85/193 (43%), Gaps = 11/193 (5%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIETECKIDVKILAIDVSSDS 128
+VTG S GIG+ ++LA G + +R E++L E ++ + + V DVSS
Sbjct: 22 LVTGGSKGIGEAVVEELATLGARIHTCARDETQLQESLRKWQAK-GFQVTTSVCDVSSRD 80
Query: 129 KENYTL--IREVASGLPVTVLINNVGKSHSIPVPFDQTEESELRDIITINNTATLMITQT 186
K + + + G + +L+NNVG I P Q + + N + ++Q
Sbjct: 81 KREKLMETVSTIFEG-KLNILVNNVGT--CIVKPTLQHTAEDFSFTMATNLESAFHLSQL 137
Query: 187 LLPQLKASVKTLKCRGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSNALAGELSSDSID 246
P LKAS G I+ + S G++ + Y SK + LA E +SD+I
Sbjct: 138 AHPLLKASGS-----GSIVLISSVSGVVHVNGASIYGVSKGAMNQLGRNLACEWASDNIR 192
Query: 247 VELVLSYLVTSAM 259
V + + + +
Sbjct: 193 TNSVCPWFIETPL 205
>Hs21361105 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 317
Score = 50.8 bits (120), Expect = 3e-06
Identities = 49/196 (25%), Positives = 91/196 (46%), Gaps = 13/196 (6%)
Query: 70 VTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIETECKIDVKILAIDVSSDSK 129
+TG G GK A+QL RG ++ TE +L+ +T +++ L + +
Sbjct: 34 ITGCDSGFGKLLARQLDARGLRVLAACLTEKGAEQLRG--QTSDRLETVTLDVTKTESVA 91
Query: 130 ENYTLIREVASGLPVTVLINNVGKSHSIP-VPFDQTEESELRDIITINNTATLMITQTLL 188
++E + L+NN G S+P P + + +L I+ +N + +T LL
Sbjct: 92 AAAQWVKECVRDKGLWGLVNNAG--ISLPTAPNELLTKQDLLTILDVNLLGVIDVTLNLL 149
Query: 189 PQLKASVKTLKCRGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSNALAGELSSDSIDVE 248
P ++ + RG ++ + S G + + F Y SK ++++S++L ELS + V
Sbjct: 150 PLVR------RARGRVVNVFSVMGRV-SLFGGGYCISKYGVEAFSDSLRRELSYFGVKVA 202
Query: 249 LV-LSYLVTSAMSKIR 263
++ Y T+ SK R
Sbjct: 203 MIEPGYFKTAVTSKER 218
>CE08067 [QR] KOG1610 Corticosteroid 11-beta-dehydrogenase and related short
chain-type dehydrogenases
Length = 388
Score = 50.8 bits (120), Expect = 3e-06
Identities = 48/190 (25%), Positives = 86/190 (45%), Gaps = 17/190 (8%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKE--IETECKIDVKILAIDVSS 126
++TG G G+ A L + N+ T+ + L E ++ K + L +DV+S
Sbjct: 36 MITGCDSGFGRLLATSLLDKHVNVFAACFTQQGMASLHSEWKLKKGPKGQLYTLQLDVTS 95
Query: 127 ----DSKENYT--LIREVASGLPVTVLINNVGKSHSIPVPFDQTEESELRDIITINNTAT 180
DS +++ +++E S L L+NN G SI P D E + +N
Sbjct: 96 QASVDSAKSFVTKILKEQNSKL--WGLVNNAG-IFSIHGPDDWCSVDEYASSLNVNTLGA 152
Query: 181 LMITQTLLPQLKASVKTLKCRGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSNALAGEL 240
+ + +P +K K RG I+TMGS G L ++A Y +K ++++ + L E+
Sbjct: 153 VRMCHAFVPLIK------KSRGRIVTMGSTAGRLHGLYVAPYVTAKFAVEAYMDCLRLEM 206
Query: 241 SSDSIDVELV 250
+ V ++
Sbjct: 207 RPFGVSVHIL 216
>At4g11410 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 317
Score = 50.8 bits (120), Expect = 3e-06
Identities = 43/147 (29%), Positives = 74/147 (50%), Gaps = 11/147 (7%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIETE---CKIDVKILAIDVS 125
+VTGAS GIG+E + LA RG ++++ R +++ +I E KIDV + +D+S
Sbjct: 33 IVTGASSGIGEETTRVLALRGVHVVMAVRNTDSGNQVRDKILKEIPQAKIDV--MKLDLS 90
Query: 126 SDSKENYTLIREVASGLPVTVLINNVGKSHSIPVPFDQTEES-ELRDIITINNTATLMIT 184
S + + LP+ +LINN G + PF + ++ EL+ N+ ++T
Sbjct: 91 SMASVRSFASEYQSLDLPLNLLINNAG---IMACPFLLSSDNIELQ--FATNHLGHFLLT 145
Query: 185 QTLLPQLKASVKTLKCRGLILTMGSFG 211
LL ++K + G I+ + S G
Sbjct: 146 NLLLERMKKTASESNREGRIVIVSSEG 172
>At4g09750 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 322
Score = 50.8 bits (120), Expect = 3e-06
Identities = 46/165 (27%), Positives = 78/165 (46%), Gaps = 20/165 (12%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIETEC-KIDVKILAIDVSSD 127
VVTGA+ GIG A+ LA RG + ++ R + + E +I+T +V + D+SS
Sbjct: 47 VVTGANSGIGFAAAEGLASRGATVYMVCRNKERGQEALSKIQTSTGNQNVYLEVCDLSSV 106
Query: 128 SKENYTLIREVASGLPVTVLINNVG----KSHSIPVPFDQTEESELRDIITINNTATLMI 183
++ + +PV VL+NN G K + P F+ + +N T +
Sbjct: 107 NEIKSFASSFASKDVPVHVLVNNAGLLENKRTTTPEGFELS--------FAVNVLGTYTM 158
Query: 184 TQTLLPQLKASVKTLKCRGLILTMGSFGGLLPTPFLA--TYSGSK 226
T+ +LP L+ + K ++T+ S GG+ +P +SG K
Sbjct: 159 TELMLPLLEKATPDAK----VITVAS-GGMYTSPLTTDLQFSGEK 198
>At1g49670_1 [IR] KOG4169 15-hydroxyprostaglandin dehydrogenase and related
dehydrogenases
Length = 305
Score = 50.8 bits (120), Expect = 3e-06
Identities = 50/178 (28%), Positives = 82/178 (45%), Gaps = 13/178 (7%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEI-ETECKIDVKIL---AIDV 124
+VTG + GIG+ LA++G + + +E K E + E K + AI V
Sbjct: 10 LVTGGASGIGRALCLALAEKGVFVTVADFSEEKGQETTSLVREANAKFHQGLSFPSAIFV 69
Query: 125 SSDSKENYTLI----REVASGLPVTVLINNVGKSHSIPVPFDQTEESEL-RDIITINNTA 179
D L+ + +A+ + + INN G S + D T+ S+ + I ++ A
Sbjct: 70 KCDVTNRGDLLAAFDKHLATFGTLDICINNAGISTPLRFDKDDTDGSKSWKHTINVDLIA 129
Query: 180 TLMITQTLLPQLKASVKTLKCRGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSNALA 237
+ TQ + +KA K G+I+ MGS GL P P Y+ SKA + ++ +LA
Sbjct: 130 VVEGTQLAIKAMKAKQKP----GVIINMGSAAGLYPMPVDPIYAASKAGVVLFTRSLA 183
>SPCC162.03 [Q] KOG1205 Predicted dehydrogenase
Length = 292
Score = 50.4 bits (119), Expect = 4e-06
Identities = 48/179 (26%), Positives = 80/179 (43%), Gaps = 28/179 (15%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLILISRT-------ESKLVELKKEIETECKIDVKILA 121
++TG+S G+G K +G+N+I SR SKL++LK ++ DVK +
Sbjct: 9 LITGSSKGLGYALVKVGLAQGYNVIACSRAPDTITIEHSKLLKLKLDV-----TDVKSVE 63
Query: 122 IDVSSDSKENYTLIREVASGLPVTVLINNVGKSHSIPVPFDQTEESELRDIITINNTATL 181
D+K + V ++INN G + + F+ E+ + +N
Sbjct: 64 -TAFKDAKRRFG---------NVDIVINNAG--YGLVGEFESYNIEEMHRQMNVNFWGVA 111
Query: 182 MITQTLLPQLKASVKTLKCRGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSNALAGEL 240
IT+ L ++ S K G IL + S G P+P L+ Y+ SK ++ S + EL
Sbjct: 112 YITKEALNLMRESGK----GGRILQISSVAGYYPSPCLSMYNASKFAVEGLSQTIMREL 166
>Hs5031737 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 280
Score = 50.4 bits (119), Expect = 4e-06
Identities = 44/194 (22%), Positives = 86/194 (43%), Gaps = 8/194 (4%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIETECKIDVKILAIDVSSDS 128
VVTG++ GIG A++LA+ G ++++ SR + + +++ E + V + V
Sbjct: 40 VVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQGE-GLSVAGIVCHVGKAE 98
Query: 129 KENYTLIREVASGLPVTVLINNVGKSHSIPVPFDQTEESELRDIITINNTATLMITQTLL 188
+ + + V L+ + G + + T E I+++N + ++ LL
Sbjct: 99 DREQLVAKALEHCGGVDFLVCSAGVNPLVGSTLG-TSEQIWDKILSVNVKSPALLLSQLL 157
Query: 189 PQLKASVKTLKCRGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSNALAGELSSDSIDVE 248
P ++ RG ++ + S P L Y+ SK L + LA EL+ I V
Sbjct: 158 PYME------NRRGAVILVSSIAAYNPVVALGVYNVSKTALLGLTRTLALELAPKDIRVN 211
Query: 249 LVLSYLVTSAMSKI 262
V+ ++ + SK+
Sbjct: 212 CVVPGIIKTDFSKV 225
>CE05427 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 293
Score = 50.4 bits (119), Expect = 4e-06
Identities = 39/132 (29%), Positives = 66/132 (49%), Gaps = 14/132 (10%)
Query: 70 VTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIETECKIDVKI------LAID 123
+TGAS GIGKE A +LAK G N+++ ++T + +L I T K +D
Sbjct: 18 ITGASRGIGKEIALKLAKDGANIVVAAKTATAHPKLPGTIYTAAAEIEKAGGHALPCVVD 77
Query: 124 VSSDSKENYTLIREVASGLPVTVLINNVGKSHSIPVPFDQTEESELR--DII-TINNTAT 180
V ++ + V + +LINN + TE+++++ D++ +IN T
Sbjct: 78 VRDEAAVKAAVDAAVKKFGGIDILINNAS-----AISLTNTEDTDMKRYDLMHSINTRGT 132
Query: 181 LMITQTLLPQLK 192
++T+T LP LK
Sbjct: 133 YLLTKTCLPYLK 144
>At5g15940 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 346
Score = 50.4 bits (119), Expect = 4e-06
Identities = 43/134 (32%), Positives = 67/134 (49%), Gaps = 13/134 (9%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIETECKIDVKILAIDVSSDS 128
V+TGA+ G+GK A LA++GF ++L+ R+ L E KEI+ + K D ++ + + S
Sbjct: 45 VITGATSGLGKATAFALAEKGFYVVLVGRSSQLLSETLKEIKNKNK-DAQLKSFEADMSS 103
Query: 129 KEN-YTLIREVASGL-------PVTVLINNVGKSHSIPVPFDQTEESELRDIITINNTAT 180
E+ +T + L + VL+NN G + P T + R I T N
Sbjct: 104 FESIFTFKNSLEQWLSDSALHPSIQVLVNNAGILATSSRP---TIDGYDRMIAT-NYVGP 159
Query: 181 LMITQTLLPQLKAS 194
+T+ LLP LK S
Sbjct: 160 FFLTKLLLPLLKNS 173
>CE03951 [R] KOG0725 Reductases with broad range of substrate specificities
Length = 277
Score = 50.1 bits (118), Expect = 5e-06
Identities = 54/233 (23%), Positives = 100/233 (42%), Gaps = 19/233 (8%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIETECKIDVKILAI--DVSS 126
++TG+S GIG+ A AK G + + R+E +L K+ + D L + D+++
Sbjct: 11 IITGSSFGIGRATALLFAKEGAKVTVTGRSEERLQGSKQALLDAGISDSNFLIVPADITT 70
Query: 127 DSKENYTLIREVASGLPVTVLINNVGKS---HSIPVPFDQTEESELRDIITINNTATLMI 183
S ++ + + + + +L+NN G S DQ ++ ++ +N + + +
Sbjct: 71 SSGQDALISKTLEKFGQINILVNNAGASIADSQNRAGLDQGIDT-YEKVLKLNVQSVIEM 129
Query: 184 TQTLLPQLKASVKTLKCRGLILTMGSFGGL----LPTPFLATYSGSKAFLQSWSNALAGE 239
TQ + P L K RG I+ + S L + P+ Y +KA L ++ + A +
Sbjct: 130 TQKIRPHL------AKTRGEIVNVSSVAALKFAHVRNPY---YPLAKAALDQYTRSAAID 180
Query: 240 LSSDSIDVELVLSYLVTSAMSKIRRSSALIPSPKAFVRSTLNSIGKRCGAQER 292
L S I V V +V + + + S K + + N CG R
Sbjct: 181 LISQGIRVNTVNPGVVATGFHESCTGLSTEESQKFYDKVGANKSAIPCGFSGR 233
>SPCC736.13 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 339
Score = 49.3 bits (116), Expect = 8e-06
Identities = 39/135 (28%), Positives = 69/135 (50%), Gaps = 9/135 (6%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIETECK-IDVKILAIDVSSD 127
+VTG+S GIG A +LA++G + L R E K ++ K+I E + ++ L +D+
Sbjct: 46 LVTGSSGGIGYVTALELARKGAKVYLAGRNEEKYQKVMKQIHDEVRHSKIRFLRLDLLDF 105
Query: 128 SKENYTLIREVASGLPVTVLINNVGKSHSIPVPFDQTEES-ELRDIITINNTATLMITQT 186
+A + +L+NN G + PF+ T++ EL+ I N + + T+
Sbjct: 106 ESVYQAAESFIAKEEKLHILVNNAGIMNP---PFELTKDGYELQ--IQTNYLSHYLFTEL 160
Query: 187 LLPQLKASVKTLKCR 201
LLP L+ + + +CR
Sbjct: 161 LLPTLRRTAE--ECR 173
>CE28291 [Q] KOG1208 Dehydrogenases with different specificities (related to
short-chain alcohol dehydrogenases)
Length = 357
Score = 49.3 bits (116), Expect = 8e-06
Identities = 39/128 (30%), Positives = 66/128 (51%), Gaps = 9/128 (7%)
Query: 70 VTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIETECKIDVKI--LAIDVSSD 127
+TG + GIG E A+ LA +G ++++ +R + +LKK IE E K DVKI ++ D++S
Sbjct: 41 ITGTTSGIGIETARALALKGAHVVMFNRNIVESEKLKKRIEEE-KPDVKIDFISCDLNSL 99
Query: 128 SKENYTLIREVASGLPVTVLINNVGK-SHSIPVPFDQTEESELRDIITINNTATLMITQT 186
++ P+ LI N G + ++ FD E +N+ A ++ +
Sbjct: 100 QSAKAAADEFLSKHWPLHGLILNAGVFAPTVKFTFDNFESH-----FGVNHLAQFLLAKE 154
Query: 187 LLPQLKAS 194
LLP L+ S
Sbjct: 155 LLPALRQS 162
>CE26060 [Q] KOG1210 Predicted 3-ketosphinganine reductase
Length = 347
Score = 49.3 bits (116), Expect = 8e-06
Identities = 47/193 (24%), Positives = 86/193 (44%), Gaps = 29/193 (15%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIETECKIDVKILAID----- 123
+VTG S GIG + A L +RG ++ +++R K++E C D+++LA
Sbjct: 42 IVTGGSKGIGFQLAVGLIERGCHVTIVARN-------VKDLEKAC-ADLQVLADQRGQRQ 93
Query: 124 ----VSSDSKENYTLIREVASGL-----PVTVLINNVGKSHSIPVPFDQTEESELRDIIT 174
S D Y +I+ P+ +LINN G HS+ PF + ++ +
Sbjct: 94 KVHWKSIDMTGGYDVIKSAFDDAARELGPIDILINNAG--HSVQAPFCELPITDFEKQMA 151
Query: 175 INNTATLMITQTLLPQLKASVKTLKCRGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSN 234
+N + + T+ ++ +K + G I + S G + YS +K L+ +++
Sbjct: 152 VNYLSAVHATRAVVDDMKT-----RKTGHISFVSSAAGQFAIFGYSAYSPTKFALRGFAD 206
Query: 235 ALAGELSSDSIDV 247
L EL ++V
Sbjct: 207 TLHMELLPYKVNV 219
>CE09002 [R] KOG1611 Predicted short chain-type dehydrogenase
Length = 250
Score = 49.3 bits (116), Expect = 8e-06
Identities = 52/195 (26%), Positives = 89/195 (44%), Gaps = 24/195 (12%)
Query: 69 VVTGASDGIGKEYAKQLAKRGF--NLILISRTESKLVELKKEIETECKIDVKILAIDVSS 126
VVTGA+ GIG +QL K ++I +R K ELK ++ V +L + V+
Sbjct: 7 VVTGANRGIGLGLVQQLVKDKNIRHIIATARDVEKATELKSIKDSR----VHVLPLTVTC 62
Query: 127 DSKEN--YTLIREVASGLPVTVLINNVGKSHSIPVPFDQTEESELRDIITINNTATLMIT 184
D + + + E+ +++LINN G S + + + + + +N T+ +++T
Sbjct: 63 DKSLDTFVSKVGEIVGSDGLSLLINNAGVLLSYGTN-TEPNRAVIAEQLDVNTTSVVLLT 121
Query: 185 QTLLPQLKASV------KTLKCRGLILTMGS--------FGGLLPTPFLATYSGSKAFLQ 230
Q LLP LK + + R ++T+ S G P LA Y SKA +
Sbjct: 122 QKLLPLLKNAASKESGDQLSVSRAAVITISSGLGSITDNTSGSAQFPVLA-YRMSKAAIN 180
Query: 231 SWSNALAGELSSDSI 245
+ LA +L D++
Sbjct: 181 MFGRTLAVDLKDDNV 195
>7290874 [Q] KOG1201 Hydroxysteroid 17-beta dehydrogenase 11
Length = 320
Score = 49.3 bits (116), Expect = 8e-06
Identities = 48/206 (23%), Positives = 88/206 (42%), Gaps = 30/206 (14%)
Query: 69 VVTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIETE--------CKIDVKIL 120
++TG G+GKE A Q AK G ++ E + KEI+ C + +
Sbjct: 62 LITGTGHGMGKEMALQYAKLGATILCWDVNEQTNNQTVKEIKNNGGKAFGYVCNVTKREE 121
Query: 121 AIDVSSDSKENYTLIREVASGLPVTVLINNVGKSHSIPV-PFDQTEESELRDIITINNTA 179
I+++ ++ + I V++NN G +P P + E+E+R + IN +
Sbjct: 122 LIELAQKVRKEHGFIH---------VVVNNAG---IMPCHPLLEHTENEIRLMYEINVLS 169
Query: 180 TLMITQTLLPQLKASVKTLKCRGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSNALAGE 239
I Q LP + + G I+ + S GL L Y G+K ++ + AL E
Sbjct: 170 HFWIIQAFLPDM-----IERNEGSIVALSSCAGLFGLINLVPYCGTKFAVRGYMAALVEE 224
Query: 240 L----SSDSIDVELVLSYLVTSAMSK 261
L +++ + + Y++ + + K
Sbjct: 225 LRQKNPQNNVKLTTIYPYMIDTGLCK 250
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.319 0.134 0.371
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,610,105
Number of Sequences: 60738
Number of extensions: 661284
Number of successful extensions: 2200
Number of sequences better than 1.0e-05: 108
Number of HSP's better than 0.0 without gapping: 13
Number of HSP's successfully gapped in prelim test: 95
Number of HSP's that attempted gapping in prelim test: 2113
Number of HSP's gapped (non-prelim): 110
length of query: 346
length of database: 30,389,216
effective HSP length: 107
effective length of query: 239
effective length of database: 23,890,250
effective search space: 5709769750
effective search space used: 5709769750
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)