ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactII2572 good I KOG0497 Lipid transport and metabolism Oxidosqualene-lanosterol cyclase and related proteins
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactII2572 889538 891730 731
(731 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YHR072w [I] KOG0497 Oxidosqualene-lanosterol cyclase and related... 1102 0.0
Hs4505027 [I] KOG0497 Oxidosqualene-lanosterol cyclase and relat... 497 e-140
At2g07050 [I] KOG0497 Oxidosqualene-lanosterol cyclase and relat... 447 e-125
At1g78970 [I] KOG0497 Oxidosqualene-lanosterol cyclase and relat... 390 e-108
At1g78960 [I] KOG0497 Oxidosqualene-lanosterol cyclase and relat... 383 e-106
At1g78950 [I] KOG0497 Oxidosqualene-lanosterol cyclase and relat... 383 e-106
At3g45130 [I] KOG0497 Oxidosqualene-lanosterol cyclase and relat... 382 e-105
SPAC4G9.21c [I] KOG0497 Oxidosqualene-lanosterol cyclase and rel... 379 e-104
At1g66960 [I] KOG0497 Oxidosqualene-lanosterol cyclase and relat... 365 e-100
At5g48010 [I] KOG0497 Oxidosqualene-lanosterol cyclase and relat... 341 2e-93
At1g78500 [I] KOG0497 Oxidosqualene-lanosterol cyclase and relat... 340 3e-93
At5g42600 [I] KOG0497 Oxidosqualene-lanosterol cyclase and relat... 332 2e-90
At4g15370 [I] KOG0497 Oxidosqualene-lanosterol cyclase and relat... 327 4e-89
At5g36150 [I] KOG0497 Oxidosqualene-lanosterol cyclase and relat... 318 2e-86
SPAC13G7.01c [I] KOG0497 Oxidosqualene-lanosterol cyclase and re... 276 1e-73
At4g15340 [I] KOG0497 Oxidosqualene-lanosterol cyclase and relat... 263 9e-70
>YHR072w [I] KOG0497 Oxidosqualene-lanosterol cyclase and related proteins
Length = 731
Score = 1102 bits (2851), Expect = 0.0
Identities = 510/726 (70%), Positives = 599/726 (82%)
Query: 1 MPELYSETIGLPRTDPKRWRLITDDLGRQTWEYLSENDSKKVPQSTFARWLLKCEDFPEP 60
M E YS+TIGLP+TDP+ WRL TD+LGR++WEYL+ + P STF +WLL+ FP+P
Sbjct: 1 MTEFYSDTIGLPKTDPRLWRLRTDELGRESWEYLTPQQAANDPPSTFTQWLLQDPKFPQP 60
Query: 61 HPEINSKTSGFTAWNAAHNGAKFFELLQDPDSGTFPCQYKGPMFMTIGYVVTMYIAKIEI 120
HPE N + F+A++A HNGA FF+LLQ+PDSG FPCQYKGPMFMTIGYV YIA IEI
Sbjct: 61 HPERNKHSPDFSAFDACHNGASFFKLLQEPDSGIFPCQYKGPMFMTIGYVAVNYIAGIEI 120
Query: 121 PEHEKAEMIRYVANYAHPVDGGWGLHHVDKSTVLGTVLNYVMMRLLGLPKDHEVCVRARD 180
PEHE+ E+IRY+ N AHPVDGGWGLH VDKSTV GTVLNYV++RLLGLPKDH VC +AR
Sbjct: 121 PEHERIELIRYIVNTAHPVDGGWGLHSVDKSTVFGTVLNYVILRLLGLPKDHPVCAKARS 180
Query: 181 TLLRLGGAIASPHWAKIWLSILNLYKWEGVNPAPPELWMLPYGLNIHPARWWVHTRGIYL 240
TLLRLGGAI SPHW KIWLS LNLYKWEGVNPAPPE W+LPY L +HP RWWVHTRG+Y+
Sbjct: 181 TLLRLGGAIGSPHWGKIWLSALNLYKWEGVNPAPPETWLLPYSLPMHPGRWWVHTRGVYI 240
Query: 241 PVSYLSSTQYSCELDPLLEEIRTEIYTQPFETIDFKKHRNTVCGVDLYYPHTKVLDTMNY 300
PVSYLS ++SC + PLLEE+R EIYT+PF+ I+F K+RNTVCGVDLYYPH+ L+ N
Sbjct: 241 PVSYLSLVKFSCPMTPLLEELRNEIYTKPFDKINFSKNRNTVCGVDLYYPHSTTLNIANS 300
Query: 301 FISKYERYVRPNWLLKKSTNRVYELVKKEIANTDYLCIAPVNNAFCAIVTLIEEGKDSEE 360
+ YE+Y+R ++ S +VY+L+K E+ NTD LCIAPVN AFCA+VTLIEEG DSE
Sbjct: 301 LVVFYEKYLRNRFIYSLSKKKVYDLIKTELQNTDSLCIAPVNQAFCALVTLIEEGVDSEA 360
Query: 361 FGRFLYRFKDVLFHGPQGLTVMGTNGVQVWDCAFYIQYMFMAGLAELPEFHETIVRSFKF 420
F R YRFKD LFHGPQG+T+MGTNGVQ WDCAF IQY F+AGLAE PEF+ TIV ++KF
Sbjct: 361 FQRLQYRFKDALFHGPQGMTIMGTNGVQTWDCAFAIQYFFVAGLAERPEFYNTIVSAYKF 420
Query: 421 LCRSQFTEDCVEGSFRDKRLGAWPFSTKTQGYTVSDCTAEAIKAIIMVLNSDKYRDVWGV 480
LC +QF +CV GS+RDKR GAW FSTKTQGYTV+DCTAEAIKAIIMV NS + +V +
Sbjct: 421 LCHAQFDTECVPGSYRDKRKGAWGFSTKTQGYTVADCTAEAIKAIIMVKNSPVFSEVHHM 480
Query: 481 YDTEKLKNGIDVLLGLQNLSSFEYGSFATYEKIKAPLLMEKLNPAEVFGNIMVEFPYVEC 540
+E+L GIDVLL LQN+ SFEYGSFATYEKIKAPL ME LNPAEVFG+IMVE+PYVEC
Sbjct: 481 ISSERLFEGIDVLLNLQNIGSFEYGSFATYEKIKAPLAMETLNPAEVFGDIMVEYPYVEC 540
Query: 541 TDSSVLGLTYFRRYFNYRKKDIDHAIDSAIAYIKKSQQPNGSWYGCWGICYTYAGMFALE 600
TDSSVLGLTYF +YF+YRK++I I AI +IKKSQ P+GSWYG WGIC+TYAGMFALE
Sbjct: 541 TDSSVLGLTYFHKYFDYRKEEIRTRIRIAIEFIKKSQLPDGSWYGSWGICFTYAGMFALE 600
Query: 601 ALNTIGETYENSEVVRKGCDFFVTKQLPDGGWSEKMKSSELHTYVSDKESYVVQTAWVLI 660
AL+T+GETYENS VRKGCDF V+KQ+ DGGW E MKSSELH+YV ++S VVQTAW LI
Sbjct: 601 ALHTVGETYENSSTVRKGCDFLVSKQMKDGGWGESMKSSELHSYVDSEKSLVVQTAWALI 660
Query: 661 GLILAKFPDKSVIDRAINLLKQRQQPSGEWKYEAVEGVFNHSCAIEYPSYRFLFPIKALG 720
L+ A++P+K VIDR I+LLK RQ+ SGEWK+E+VEGVFNHSCAIEYPSYRFLFPIKALG
Sbjct: 661 ALLFAEYPNKEVIDRGIDLLKNRQEESGEWKFESVEGVFNHSCAIEYPSYRFLFPIKALG 720
Query: 721 LYVKEY 726
+Y + Y
Sbjct: 721 MYSRAY 726
>Hs4505027 [I] KOG0497 Oxidosqualene-lanosterol cyclase and related proteins
Length = 732
Score = 497 bits (1280), Expect = e-140
Identities = 271/732 (37%), Positives = 415/732 (56%), Gaps = 33/732 (4%)
Query: 12 PRTDPKRWRLITDDLGRQTWEYLSENDSKKVPQSTFARWLLKCE------DFPEPHPEIN 65
P TD RWRL + GRQTW YL + + + Q+ + L + D P+ H
Sbjct: 18 PATDLGRWRL-NCERGRQTWTYLQDERAGR-EQTGLEAYALGLDTKNYFKDLPKAH---- 71
Query: 66 SKTSGFTAWNAAHNGAKFFELLQDPDSGTFPCQYKGPMFMTIGYVVTMYIAKIEIPEHEK 125
TA+ A NG F+ LQ D G + Y GP+F+ G ++T ++A+I +P +
Sbjct: 72 ------TAFEGALNGMTFYVGLQAED-GHWTGDYGGPLFLLPGLLITCHVARIPLPAGYR 124
Query: 126 AEMIRYVANYAHPVDGGWGLHHVDKSTVLGTVLNYVMMRLLGLPKDHEVCVRARDTLLRL 185
E++RY+ + P DGGWGLH DKSTV GT LNYV +R+LG+ D VRAR+ L +
Sbjct: 125 EEIVRYLRSVQLP-DGGWGLHIEDKSTVFGTALNYVSLRILGVGPDDPDLVRARNILHKK 183
Query: 186 GGAIASPHWAKIWLSILNLYKWEGVNPAPPELWMLPYGLNIHPARWWVHTRGIYLPVSYL 245
GGA+A P W K WL++LN+Y WEG+N PE+W+ P HP+ W H R +YLP+SY
Sbjct: 184 GGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCHCRQVYLPMSYC 243
Query: 246 SSTQYSCELDPLLEEIRTEIYTQPFETIDFKKHRNTVCGVDLYYPHTKVLDTMNYFISKY 305
+ + S DPL++ +R E+Y + F +ID+ RN V +LY PH+ +L + ++ Y
Sbjct: 244 YAVRLSAAEDPLVQSLRQELYVEDFASIDWLAQRNNVAPDELYTPHSWLLRVVYALLNLY 303
Query: 306 ERYVRPNWLLKKSTNRVYELVKKEIANTDYLCIAPVNNAFCAIVTLIEEGKDSEEFGRFL 365
E + + L +++ ++YE + + T + I P++ +V +G S F +
Sbjct: 304 EHHHSAH-LRQRAVQKLYEHIVADDRFTKSISIGPISKTINMLVRWYVDGPASTAFQEHV 362
Query: 366 YRFKDVLFHGPQGLTVMGTNGVQVWDCAFYIQYMFMAGLAELPEFHETIVRSFKFLCRSQ 425
R D L+ G G+ + GTNG Q+WD AF IQ + AG PEF + ++ +FL SQ
Sbjct: 363 SRIPDYLWMGLDGMKMQGTNGSQIWDTAFAIQALLEAGGHHRPEFSSCLQKAHEFLRLSQ 422
Query: 426 FTED--CVEGSFRDKRLGAWPFSTKTQGYTVSDCTAEAIKAIIMVLNSDKYRDVWGVYDT 483
++ + +R R G + FST G+ VSDCTAEA+KA++++ +K V
Sbjct: 423 VPDNPPDYQKYYRQMRKGGFSFSTLDCGWIVSDCTAEALKAVLLL--QEKCPHVTEHIPR 480
Query: 484 EKLKNGIDVLLGLQNLSSFEYGSFATYEKIKAPLLMEKLNPAEVFGNIMVEFPYVECTDS 543
E+L + + VLL ++N G FATYE + L+E LNP+EVFG+IM+++ YVECT +
Sbjct: 481 ERLCDAVAVLLNMRNPD----GGFATYETKRGGHLLELLNPSEVFGDIMIDYTYVECTSA 536
Query: 544 SVLGLTYF-RRYFNYRKKDIDHAIDSAIAYIKKSQQPNGSWYGCWGICYTYAGMFALEAL 602
+ L YF +R+ +R +I + + + ++ Q+ +GSW G WG+C+TY F LEA
Sbjct: 537 VMQALKYFHKRFPEHRAAEIRETLTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAF 596
Query: 603 NTIGETYENSEV---VRKGCDFFVTKQLPDGGWSEKMKSSELHTYVSDKESYVVQTAWVL 659
+G+TY + V + CDF +++Q+ DGGW E +S E Y+ +S + T W +
Sbjct: 597 ACMGQTYRDGTACAEVSRACDFLLSRQMADGGWGEDFESCEERRYLQSAQSQIHNTCWAM 656
Query: 660 IGLILAKFPDKSVIDRAINLLKQRQQPSGEWKYEAVEGVFNHSCAIEYPSYRFLFPIKAL 719
+GL+ + PD +R + L ++Q P+G+W E + GVFN SCAI Y SYR +FPI AL
Sbjct: 657 MGLMAVRHPDIEAQERGVRCLLEKQLPNGDWPQENIAGVFNKSCAISYTSYRNIFPIWAL 716
Query: 720 GLYVKEYGHSAI 731
G + + Y A+
Sbjct: 717 GRFSQLYPERAL 728
>At2g07050 [I] KOG0497 Oxidosqualene-lanosterol cyclase and related proteins
Length = 759
Score = 447 bits (1150), Expect = e-125
Identities = 249/660 (37%), Positives = 370/660 (55%), Gaps = 27/660 (4%)
Query: 80 GAKFFELLQDPDSGTFPCQYKGPMFMTIGYVVTMYIA---KIEIPEHEKAEMIRYVANYA 136
G F+ +Q D G +P Y GPMF+ G ++T+ I + E K EM RY+ N+
Sbjct: 100 GLDFYSTIQAHD-GHWPGDYGGPMFLLPGLIITLSITGALNTVLSEQHKQEMRRYLYNHQ 158
Query: 137 HPVDGGWGLHHVDKSTVLGTVLNYVMMRLLGL-PKDHEVCV-RARDTLLRLGGAIASPHW 194
+ DGGWGLH ST+ G+VLNYV +RLLG P D + + + RD +L GGA W
Sbjct: 159 NE-DGGWGLHIEGPSTMFGSVLNYVTLRLLGEGPNDGDGDMEKGRDWILNHGGATNITSW 217
Query: 195 AKIWLSILNLYKWEGVNPAPPELWMLPYGLNIHPARWWVHTRGIYLPVSYLSSTQYSCEL 254
K+WLS+L ++W G NP PPE+W+LPY L IHP R W H R +YLP+SYL ++ +
Sbjct: 218 GKMWLSVLGAFEWSGNNPLPPEIWLLPYFLPIHPGRMWCHCRMVYLPMSYLYGKRFVGPI 277
Query: 255 DPLLEEIRTEIYTQPFETIDFKKHRNTVCGVDLYYPHTKVLDTMNYFISKYERYVRPNW- 313
+ +R E++T P+ +++ + RN DLYYPH V D + + K V W
Sbjct: 278 TSTVLSLRKELFTVPYHEVNWNEARNLCAKEDLYYPHPLVQDILWASLHKIVEPVLMRWP 337
Query: 314 ---LLKKSTNRVYELVKKEIANTDYLCIAPVNNAFCAIVTLIEEGKDSEEFGRFLYRFKD 370
L +K+ E + E NT Y+CI PVN + +E+ +SE F L R D
Sbjct: 338 GANLREKAIRTAIEHIHYEDENTRYICIGPVNKVLNMLCCWVED-PNSEAFKLHLPRIHD 396
Query: 371 VLFHGPQGLTVMGTNGVQVWDCAFYIQYMFMAGLAELPEFHETIVRSFKFLCRSQFTEDC 430
L+ G+ + G NG Q+WD F IQ + L E E+ + ++ F+ SQ EDC
Sbjct: 397 FLWLAEDGMKMQGYNGSQLWDTGFAIQAILATNLVE--EYGPVLEKAHSFVKNSQVLEDC 454
Query: 431 ---VEGSFRDKRLGAWPFSTKTQGYTVSDCTAEAIKAIIMVLNSDKYRDVWGVYDTEKLK 487
+ +R GAWPFST G+ +SDCTAE +KA +++ K V D ++L
Sbjct: 455 PGDLNYWYRHISKGAWPFSTADHGWPISDCTAEGLKAALLLSKVPK-AIVGEPIDAKRLY 513
Query: 488 NGIDVLLGLQNLSSFEYGSFATYEKIKAPLLMEKLNPAEVFGNIMVEFPYVECTDSSVLG 547
++V++ LQN G ATYE ++ +E +NPAE FG+I++++PYVECT +++
Sbjct: 514 EAVNVIISLQNAD----GGLATYELTRSYPWLELINPAETFGDIVIDYPYVECTSAAIQA 569
Query: 548 LTYFRR-YFNYRKKDIDHAIDSAIAYIKKSQQPNGSWYGCWGICYTYAGMFALEALNTIG 606
L FR+ Y +RKK++D I+ A+ +I+ Q +GSWYG W +C+TY F ++ L +G
Sbjct: 570 LISFRKLYPGHRKKEVDECIEKAVKFIESIQAADGSWYGSWAVCFTYGTWFGVKGLVAVG 629
Query: 607 ETYENSEVVRKGCDFFVTKQLPDGGWSEKMKS--SELHTYVSDKESYVVQTAWVLIGLIL 664
+T +NS V K C+F ++KQ P GGW E S ++++ + S+VV TAW ++ LI
Sbjct: 630 KTLKNSPHVAKACEFLLSKQQPSGGWGESYLSCQDKVYSNLDGNRSHVVNTAWAMLALIG 689
Query: 665 A--KFPDKSVIDRAINLLKQRQQPSGEWKYEAVEGVFNHSCAIEYPSYRFLFPIKALGLY 722
A D+ + RA L Q +G++ + + GVFN +C I Y +YR +FPI ALG Y
Sbjct: 690 AGQAEVDRKPLHRAARYLINAQMENGDFPQQEIMGVFNRNCMITYAAYRNIFPIWALGEY 749
>At1g78970 [I] KOG0497 Oxidosqualene-lanosterol cyclase and related proteins
Length = 757
Score = 390 bits (1001), Expect = e-108
Identities = 238/673 (35%), Positives = 358/673 (52%), Gaps = 35/673 (5%)
Query: 72 TAWNAAHNGAKFFELLQDPDSGTFPCQYKGPMFMTIGYVVTMYIA----KIEIPEHEKAE 127
T NA G ++F LQ D G +P + GP+F + +YI ++ EH K E
Sbjct: 94 TTTNALRRGVRYFTALQASD-GHWPGEITGPLFFLPPLIFCLYITGHLEEVFDAEHRK-E 151
Query: 128 MIRYVANYAHP-VDGGWGLHHVDKSTVLGTVLNYVMMRLLGLPKDHEVCVRARDTLLRLG 186
M+R++ Y H DGGWGLH KS + TVLNY+ +R+LG + + C RAR +L G
Sbjct: 152 MLRHI--YCHQNEDGGWGLHIESKSVMFCTVLNYICLRMLGENPEQDACKRARQWILDRG 209
Query: 187 GAIASPHWAKIWLSILNLYKWEGVNPAPPELWMLPYGLNIHPARWWVHTRGIYLPVSYLS 246
G I P W K WLSIL +Y W G NP PPEL MLP L IHP + ++R + +P+SYL
Sbjct: 210 GVIFIPSWGKFWLSILGVYDWSGTNPTPPELLMLPSFLPIHPGKILCYSRMVSIPMSYLY 269
Query: 247 STQYSCELDPLLEEIRTEIYTQPFETIDFKKHRNTVCGVDLYYPHTKVLDTMNYFISKYE 306
++ + PL+ +R E+Y +P+E I++KK R D+YY H V D ++ + +
Sbjct: 270 GKRFVGPITPLILLLREELYLEPYEEINWKKSRRLYAKEDMYYAHPLVQDLLSDTLQNFV 329
Query: 307 RYVRPNWLLKKST-NRVYELVKKEI----ANTDYLCIAPVNNAFCAIVTLIEEGKDSEEF 361
+ W L K + +L K I N+ Y+ I V C + + E + + F
Sbjct: 330 EPLLTRWPLNKLVREKALQLTMKHIHYEDENSHYITIGCVEKVLCMLACWV-ENPNGDYF 388
Query: 362 GRFLYRFKDVLFHGPQGLTVMGTNGVQVWDCAFYIQYMFMAGLAELPEFHETIVRSFKFL 421
+ L R D ++ G+ M + G Q+WD F IQ + + L + E + + R ++
Sbjct: 389 KKHLARIPDYMWVAEDGMK-MQSFGCQLWDTGFAIQALLASNLPD--ETDDALKRGHNYI 445
Query: 422 CRSQFTEDCVEGSFRDK----RLGAWPFSTKTQGYTVSDCTAEAIKAIIMVLNSDKYRDV 477
SQ E+ G FR GAW FS + G+ VSDCTAEA+K +++ S D+
Sbjct: 446 KASQVREN-PSGDFRSMYRHISKGAWTFSDRDHGWQVSDCTAEALKCCLLL--SMMSADI 502
Query: 478 WG-VYDTEKLKNGIDVLLGLQNLSSFEYGSFATYEKIKAPLLMEKLNPAEVFGNIMVEFP 536
G D E+L + +++LL LQ+ + G +E +A +E LNP E N MVE
Sbjct: 503 VGQKIDDEQLYDSVNLLLSLQSGN----GGVNAWEPSRAYKWLELLNPTEFMANTMVERE 558
Query: 537 YVECTDSSVLGLTYFRR-YFNYRKKDIDHAIDSAIAYIKKSQQPNGSWYGCWGICYTYAG 595
+VECT S + L FR+ Y ++RKK+I+ +I+ A+ +I+ +Q P+GSWYG WG+C+ YA
Sbjct: 559 FVECTSSVIQALDLFRKLYPDHRKKEINRSIEKAVQFIQDNQTPDGSWYGNWGVCFIYAT 618
Query: 596 MFALEALNTIGETYENSEVVRKGCDFFVTKQLPDGGWSEKMKSSELHTYV--SDKESYVV 653
FAL L GETY + +R G F +T Q DGGW E S Y+ + S +V
Sbjct: 619 WFALGGLAAAGETYNDCLAMRNGVHFLLTTQRDDGGWGESYLSCSEQRYIPSEGERSNLV 678
Query: 654 QTAWVLIGLILAKFPDKSVI--DRAINLLKQRQQPSGEWKYEAVEGVFNHSCAIEYPSYR 711
QT+W ++ LI ++ +I RA L+ Q +G++ + + G F ++C + Y +YR
Sbjct: 679 QTSWAMMALIHTGQAERDLIPLHRAAKLIINSQLENGDFPQQEIVGAFMNTCMLHYATYR 738
Query: 712 FLFPIKALGLYVK 724
FP+ AL Y K
Sbjct: 739 NTFPLWALAEYRK 751
>At1g78960 [I] KOG0497 Oxidosqualene-lanosterol cyclase and related proteins
Length = 759
Score = 383 bits (984), Expect = e-106
Identities = 236/673 (35%), Positives = 353/673 (52%), Gaps = 34/673 (5%)
Query: 73 AWNAAHNGAKFFELLQDPDSGTFPCQYKGPMF----MTIGYVVTMYIAKIEIPEHEKAEM 128
A +A F+ LQ D G +P + G +F + + +T ++ KI EH K EM
Sbjct: 91 ATDALRRAVSFYSALQSSD-GHWPAEITGTLFFLPPLVFCFYITGHLEKIFDAEHRK-EM 148
Query: 129 IRYVANYAHP-VDGGWGLHHVDKSTVLGTVLNYVMMRLLGLPKD---HEVCVRARDTLLR 184
+R++ Y H DGGWGLH KS + TVLNY+ +R+LG + + C RAR +L
Sbjct: 149 LRHI--YCHQNEDGGWGLHIEGKSVMFCTVLNYICLRMLGEGPNGGRNNACKRARQWILD 206
Query: 185 LGGAIASPHWAKIWLSILNLYKWEGVNPAPPELWMLPYGLNIHPARWWVHTRGIYLPVSY 244
GG P W KIWLSIL +Y W G NP PPE+W+LP IH + +TR +Y+P+SY
Sbjct: 207 HGGVTYIPSWGKIWLSILGIYDWSGTNPMPPEIWLLPSFFPIHLGKTLCYTRMVYMPMSY 266
Query: 245 LSSTQYSCELDPLLEEIRTEIYTQPFETIDFKKHRNTVCGVDLYYPHTKVLDTMNYFISK 304
L ++ L PL+ +R E++ QP+E I++ K R D+ YPH V D + +
Sbjct: 267 LYGKRFVGPLTPLIMLLRKELHLQPYEEINWNKARRLCAKEDMIYPHPLVQDLLWDTLHN 326
Query: 305 YERYVRPNWLLKKSTNR-----VYELVKKEIANTDYLCIAPVNNAFCAIVTLIEEGKDSE 359
+ + NW LKK E + E N+ Y+ I V C + I E + +
Sbjct: 327 FVEPILTNWPLKKLVREKALRVAMEHIHYEDENSHYITIGCVEKVLCMLACWI-ENPNGD 385
Query: 360 EFGRFLYRFKDVLFHGPQGLTVMGTNGVQVWDCAFYIQYMFMAGLAELPEFHETIVRSFK 419
F + L R D ++ GL M + G Q+WD F IQ + L++ E + + +
Sbjct: 386 HFKKHLARIPDFMWVAEDGLK-MQSFGSQLWDTVFAIQALLACDLSD--ETDDVLRKGHS 442
Query: 420 FLCRSQFTED---CVEGSFRDKRLGAWPFSTKTQGYTVSDCTAEAIKAIIMVLNSDKYRD 476
F+ +SQ E+ + +R GAW S + G+ VSDCTAEA+K M+L+
Sbjct: 443 FIKKSQVRENPSGDFKSMYRHISKGAWTLSDRDHGWQVSDCTAEALKC-CMLLSMMPAEV 501
Query: 477 VWGVYDTEKLKNGIDVLLGLQNLSSFEYGSFATYEKIKAPLLMEKLNPAEVFGNIMVEFP 536
V D E+L + +++LL LQ E G +E ++A +E LNP + F +M E
Sbjct: 502 VGQKIDPEQLYDSVNLLLSLQG----EKGGLTAWEPVRAQEWLELLNPTDFFTCVMAERE 557
Query: 537 YVECTDSSVLGLTYFRR-YFNYRKKDIDHAIDSAIAYIKKSQQPNGSWYGCWGICYTYAG 595
YVECT + + L F++ Y ++R K+I +I+ + +I+ Q P+GSW+G WGIC+ YA
Sbjct: 558 YVECTSAVIQALVLFKQLYPDHRTKEIIKSIEKGVQFIESKQTPDGSWHGNWGICFIYAT 617
Query: 596 MFALEALNTIGETYENSEVVRKGCDFFVTKQLPDGGWSEKMKSSELHTYV--SDKESYVV 653
FAL L G+TY++ VRKG DF + Q DGGW E S Y+ S +V
Sbjct: 618 WFALSGLAAAGKTYKSCLAVRKGVDFLLAIQEEDGGWGESHLSCPEQRYIPLEGNRSNLV 677
Query: 654 QTAWVLIGLILA--KFPDKSVIDRAINLLKQRQQPSGEWKYEAVEGVFNHSCAIEYPSYR 711
QTAW ++GLI A D + + RA L+ Q +G++ + + GVF ++C + Y +YR
Sbjct: 678 QTAWAMMGLIHAGQAERDPTPLHRAAKLIITSQLENGDFPQQEILGVFMNTCMLHYATYR 737
Query: 712 FLFPIKALGLYVK 724
+FP+ AL Y K
Sbjct: 738 NIFPLWALAEYRK 750
>At1g78950 [I] KOG0497 Oxidosqualene-lanosterol cyclase and related proteins
Length = 1494
Score = 383 bits (983), Expect = e-106
Identities = 250/745 (33%), Positives = 377/745 (50%), Gaps = 63/745 (8%)
Query: 26 LGRQTWEYLSE------------------NDSKKVPQSTFARW---LLKCEDFPEPHP-- 62
LGRQTWE+ + +D +V S+ W LK + F + P
Sbjct: 23 LGRQTWEFDPDAGTVEELAAVEEARRKFYDDRFRVKASSDLIWRMQFLKEKKFEQVIPPA 82
Query: 63 ---EINSKTSGFTAWNAAHNGAKFFELLQDPDSGTFPCQYKGPMFMTIGYVVTMYIA--- 116
+ N+ TS A NA G F LQ D G +P + GP+F V +Y+
Sbjct: 83 KVEDANNITSEI-ATNALRKGVNFLSALQASD-GHWPAENAGPLFFLPPLVFCLYVTGHL 140
Query: 117 -KIEIPEHEKAEMIRYVANYAHP-VDGGWGLHHVDKSTVLGTVLNYVMMRLLGLPKDH-- 172
+I +H + E++RY+ Y H DGGWGLH ST+ T LNY+ MR+LG +
Sbjct: 141 HEIFTQDHRR-EVLRYI--YCHQNEDGGWGLHIEGNSTMFCTTLNYICMRILGEGPNGGP 197
Query: 173 -EVCVRARDTLLRLGGAIASPHWAKIWLSILNLYKWEGVNPAPPELWMLPYGLNIHPARW 231
C RARD +L GGA P W K WLSIL ++ W G NP PPE W+LP L IHPA+
Sbjct: 198 GNACKRARDWILDHGGATYIPSWGKTWLSILGVFDWSGSNPMPPEFWILPSFLPIHPAKM 257
Query: 232 WVHTRGIYLPVSYLSSTQYSCELDPLLEEIRTEIYTQPFETIDFKKHRNTVCGVDLYYPH 291
W + R +Y+P+SYL ++ + PL+ ++R EIY QP+ I++ + R+ D Y PH
Sbjct: 258 WCYCRLVYMPMSYLYGKRFVGPISPLILQLREEIYLQPYAKINWNRARHLCAKEDAYCPH 317
Query: 292 TKVLDTMNYFISKYERYVRPNW-----LLKKSTNRVYELVKKEIANTDYLCIAPVNNAFC 346
++ D + + + W L +K+ + + E N+ Y+ I V A C
Sbjct: 318 PQIQDVIWNCLYIFTEPFLACWPFNKLLREKALGVAMKHIHYEDENSRYITIGCVEKALC 377
Query: 347 AIVTLIEEGKDSEEFGRFLYRFKDVLFHGPQGLTVMGTNGVQVWDCAFYIQYMFMAGLAE 406
+ +E+ + F + L R D L+ G+ M + G Q+WD F +Q + + L
Sbjct: 378 MLACWVED-PNGIHFKKHLLRISDYLWIAEDGMK-MQSFGSQLWDSGFALQALVASNLVN 435
Query: 407 LPEFHETIVRSFKFLCRSQFTED---CVEGSFRDKRLGAWPFSTKTQGYTVSDCTAEAIK 463
E + + R + FL SQ E+ +R G+W FS + G+ SDCTAE+ K
Sbjct: 436 --EIPDVLRRGYDFLKNSQVRENPSGDFTNMYRHISKGSWTFSDRDHGWQASDCTAESFK 493
Query: 464 AIIMVLNSDKYRDVWG-VYDTEKLKNGIDVLLGLQNLSSFEYGSFATYEKIKAPLLMEKL 522
+++ S D+ G D E+L + +LL LQ+ + G +E + +E L
Sbjct: 494 CCLLL--SMIPPDIVGPKMDPEQLYEAVTILLSLQS----KNGGVTAWEPARGQEWLELL 547
Query: 523 NPAEVFGNIMVEFPYVECTDSSVLGLTYFRR-YFNYRKKDIDHAIDSAIAYIKKSQQPNG 581
NP EVF +I+VE Y ECT S++ L F++ Y N+R ++I+ +I A+ YI+ Q +G
Sbjct: 548 NPTEVFADIVVEHEYNECTSSAIQALILFKQLYPNHRTEEINTSIKKAVQYIESIQMLDG 607
Query: 582 SWYGCWGICYTYAGMFALEALNTIGETYENSEVVRKGCDFFVTKQLPDGGWSEKMKSSEL 641
SWYG WG+C+TY+ F L L G+TY N +RKG F +T Q +GGW E S
Sbjct: 608 SWYGSWGVCFTYSTWFGLGGLAAAGKTYNNCLAMRKGVHFLLTTQKDNGGWGESYLSCPK 667
Query: 642 HTYV--SDKESYVVQTAWVLIGLILA--KFPDKSVIDRAINLLKQRQQPSGEWKYEAVEG 697
Y+ + S +VQT+W ++GL+ A D S + RA LL Q +G++ + + G
Sbjct: 668 KRYIPSEGERSNLVQTSWAMMGLLHAGQAERDPSPLHRAAKLLINSQLENGDFPQQEITG 727
Query: 698 VFNHSCAIEYPSYRFLFPIKALGLY 722
F +C + Y +YR +FP+ AL Y
Sbjct: 728 AFMKNCLLHYAAYRNIFPVWALAEY 752
Score = 372 bits (954), Expect = e-102
Identities = 244/728 (33%), Positives = 365/728 (49%), Gaps = 52/728 (7%)
Query: 27 GRQTWEYLSENDSKKVPQSTF-ARWLLKCEDFPEPHPEINSKTSGFTAWNAAHNGAKFFE 85
GRQTWE+ + S + S AR + F + K S W K FE
Sbjct: 780 GRQTWEFDPDGGSPEERHSVVEARRIFYDNRF-------HVKASSDLLWRMQFLREKKFE 832
Query: 86 LLQDP---------DSGTFPCQYKGPMFMTIGYVVTMYIA----KIEIPEHEKAEMIRYV 132
P G +P + GP+F V +YI ++ EH K E++RY+
Sbjct: 833 QRIAPVKVEDSEKASDGHWPAENAGPLFFLPPLVFCLYITGHLDEVFTSEHRK-EILRYI 891
Query: 133 ANYAHPV-DGGWGLHHVDKSTVLGTVLNYVMMRLLGLPKD---HEVCVRARDTLLRLGGA 188
Y H DGGWGLH ST+ T LNY+ MR+LG D C RAR+ +L GG
Sbjct: 892 --YCHQKEDGGWGLHIEGHSTMFCTTLNYICMRILGESPDGGHDNACGRAREWILSHGGV 949
Query: 189 IASPHWAKIWLSILNLYKWEGVNPAPPELWMLPYGLNIHPARWWVHTRGIYLPVSYLSST 248
P W K WLSIL ++ W G NP PPE W+LP +HPA+ W + R +YLP+SYL
Sbjct: 950 TYIPSWGKTWLSILGVFDWSGSNPMPPEFWILPSFFPVHPAKMWSYCRMVYLPMSYLYGK 1009
Query: 249 QYSCELDPLLEEIRTEIYTQPFETIDFKKHRNTVCGVDLYYP----HTKVLDTMNYFISK 304
++ + L+ ++R E+Y QP+E I++ K R+ D YYP V D++ F
Sbjct: 1010 RFVGPITSLILQLRKELYLQPYEEINWMKVRHLCAKEDTYYPRPLVQELVWDSLYIFAEP 1069
Query: 305 Y-ERYVRPNWLLKKSTNRVYELVKKEIANTDYLCIAPVNNAFCAIVTLIEEGKDSEEFGR 363
+ R+ L +K+ + + E N+ Y+ I V C + +E+ + + F +
Sbjct: 1070 FLARWPFNKLLREKALQLAMKHIHYEDENSRYITIGCVEKVLCMLACWVED-PNGDYFKK 1128
Query: 364 FLYRFKDVLFHGPQGLTVMGTNGVQVWDCAFYIQYMFMAGLAELPEFHETIVRSFKFLCR 423
L R D L+ G+ M + G Q+WD F +Q + + L+ E + + R +F+
Sbjct: 1129 HLSRISDYLWMAEDGMK-MQSFGSQLWDTGFAMQALLASNLSS--EISDVLRRGHEFIKN 1185
Query: 424 SQFTED---CVEGSFRDKRLGAWPFSTKTQGYTVSDCTAEAIKAIIMVLNSDKYRDVWG- 479
SQ E+ + +R GAW FS + G+ VSDCTA +K + L S D+ G
Sbjct: 1186 SQVGENPSGDYKSMYRHISKGAWTFSDRDHGWQVSDCTAHGLKCCL--LFSMLAPDIVGP 1243
Query: 480 VYDTEKLKNGIDVLLGLQNLSSFEYGSFATYEKIKAPLLMEKLNPAEVFGNIMVEFPYVE 539
D E+L + +++LL LQ+ + G +E AP +E LNP E+F +I++E Y E
Sbjct: 1244 KQDPERLHDSVNILLSLQS----KNGGMTAWEPAGAPKWLELLNPTEMFSDIVIEHEYSE 1299
Query: 540 CTDSSVLGLTYFRR-YFNYRKKDIDHAIDSAIAYIKKSQQPNGSWYGCWGICYTYAGMFA 598
CT S++ L+ F++ Y ++R +I I A Y++ Q +GSWYG WGIC+TY FA
Sbjct: 1300 CTSSAIQALSLFKQLYPDHRTTEITAFIKKAAEYLENMQTRDGSWYGNWGICFTYGTWFA 1359
Query: 599 LEALNTIGETYENSEVVRKGCDFFVTKQLPDGGWSEKMKSSELHTYVSD--KESYVVQTA 656
L L G+T+ + E +RKG F + Q +GGW E S Y++ + S VVQTA
Sbjct: 1360 LAGLAAAGKTFNDCEAIRKGVQFLLAAQKDNGGWGESYLSCSKKIYIAQVGEISNVVQTA 1419
Query: 657 WVLIGLILAKFPDKSVI--DRAINLLKQRQQPSGEWKYEAVEGVFNHSCAIEYPSYRFLF 714
W L+GLI + ++ I RA L+ Q SG++ + GVF +C + Y +YR +
Sbjct: 1420 WALMGLIHSGQAERDPIPLHRAAKLIINSQLESGDFPQQQATGVFLKNCTLHYAAYRNIH 1479
Query: 715 PIKALGLY 722
P+ AL Y
Sbjct: 1480 PLWALAEY 1487
>At3g45130 [I] KOG0497 Oxidosqualene-lanosterol cyclase and related proteins
Length = 742
Score = 382 bits (980), Expect = e-105
Identities = 219/640 (34%), Positives = 341/640 (53%), Gaps = 41/640 (6%)
Query: 82 KFFELLQDPDSGTFPCQYKGPMFMTIGYVVTMYIAKI---EIPEHEKAEMIRYVANYAHP 138
+F+ +LQ D G +P Y GP+F+ V+ +Y+ ++ + + E+ RY+ N+ +
Sbjct: 102 RFYSILQSQD-GFWPGDYGGPLFLLPALVIGLYVTEVLDGTLTAQHQIEIRRYLYNHQNK 160
Query: 139 VDGGWGLHHVDKSTVLGTVLNYVMMRLLGLPKD--HEVCVRARDTLLRLGGAIASPHWAK 196
DGGWGLH ST+ TVL+YV +RL+G D AR + GGA P W K
Sbjct: 161 -DGGWGLHVEGNSTMFCTVLSYVALRLMGEELDGGDGAMESARSWIHHHGGATFIPSWGK 219
Query: 197 IWLSILNLYKWEGVNPAPPELWMLPYGLNIHPARWWVHTRGIYLPVSYLSSTQYSCELDP 256
WLS+L Y+W G NP PPELW+LPY L HP R W H R +YLP+SYL ++ C +
Sbjct: 220 FWLSVLGAYEWSGNNPLPPELWLLPYSLPFHPGRMWCHCRMVYLPMSYLYGRRFVCRTNG 279
Query: 257 LLEEIRTEIYTQPFETIDFKKHRNTVCGVDLYYPHTKVLDTMNYFISKYERYVRPNWLLK 316
+ +R E+YT P+ ID+ RN DLYYPH K+ D + ++K+ + W L
Sbjct: 280 TILSLRRELYTIPYHHIDWDTARNQCAKEDLYYPHPKIQDVLWSCLNKFGEPLLERWPLN 339
Query: 317 KSTNRVYELVKKEI----ANTDYLCIAPVN---NAFCAIVTLIEEGKDSEEFGRFLYRFK 369
N + V + I N+ Y+CI PVN N C V E +SE F L R K
Sbjct: 340 NLRNHALQTVMQHIHYEDQNSHYICIGPVNKVLNMLCCWV----ESSNSEAFKSHLSRIK 395
Query: 370 DVLFHGPQGLTVMGTNGVQVWDCAFYIQYMFMAGLAELPEFHETIVRSFKFLCRSQFTED 429
D L+ G+ + G NG Q+WD +Q + L + ++ + ++ ++ +Q +D
Sbjct: 396 DYLWVAEDGMKMQGYNGSQLWDVTLAVQAILATNLVD--DYGLMLKKAHNYIKNTQIRKD 453
Query: 430 CVEGS---FRDKRLGAWPFSTKTQGYTVSDCTAEAIKAIIMVLNSDKYRDVWGVYDTEKL 486
+R G W FST + VSDCTAEA+KA ++ L+ V E L
Sbjct: 454 TSGDPGLWYRHPCKGGWGFSTGDNPWPVSDCTAEALKAALL-LSQMPVNLVGEPMPEEHL 512
Query: 487 KNGIDVLLGLQNLSSFEYGSFATYEKIKAPLLMEKLNPAEVFGNIMVEFPYVECTDSSVL 546
+ + + G FA+YE ++ +E +NP+E FG+I++++ YVECT +++
Sbjct: 513 ------------VDANKNGGFASYELTRSYPELEVINPSETFGDIIIDYQYVECTSAAIQ 560
Query: 547 GLTYFRRY-FNYRKKDIDHAIDSAIAYIKKSQQPNGSWYGCWGICYTYAGMFALEALNTI 605
GL F +Y++K+I +I+ A+ +I+K+Q P+GSWYG WG+C+TYA F ++ +
Sbjct: 561 GLVLFTTLNSSYKRKEIVGSINKAVEFIEKTQLPDGSWYGSWGVCFTYATWFGIKGMLAS 620
Query: 606 GETYENSEVVRKGCDFFVTKQLPDGGWSEKMKS--SELHTYVSDKESYVVQTAWVLIGLI 663
G+TYE+S +RK C F ++KQL GGW E S ++++T + +S++V T+W L+ LI
Sbjct: 621 GKTYESSLCIRKACGFLLSKQLCCGGWGESYLSCQNKVYTNLPGNKSHIVNTSWALLALI 680
Query: 664 LA--KFPDKSVIDRAINLLKQRQQPSGEWKYEAVEGVFNH 701
A D + R L Q G++ + + + H
Sbjct: 681 EAGQASRDPMPLHRGAKSLINSQMEDGDYPQQVSKMFYIH 720
>SPAC4G9.21c [I] KOG0497 Oxidosqualene-lanosterol cyclase and related proteins
Length = 431
Score = 379 bits (972), Expect = e-104
Identities = 187/434 (43%), Positives = 266/434 (61%), Gaps = 8/434 (1%)
Query: 296 DTMNYFISKYERYVRPNWLLKKSTNRVYELVKKEIANTDYLCIAPVNNAFCAIVTLIEEG 355
D +N+ + KY Y+RP+WL K T R YEL+K E NTDY CI PVN A + EG
Sbjct: 1 DRLNWILEKYFTYLRPSWLKKLGTRRAYELIKIEDQNTDYSCIGPVNAAMNTVCVYFHEG 60
Query: 356 KDSEEFGRFLYRFKDVLFHGPQGLTVMGTNGVQVWDCAFYIQYMFMAGLAELPEFHETIV 415
S+ F + + R D ++ P+G+ + GTNG+QVW+ +F +Q + +GL E F I
Sbjct: 61 PSSKAFQKHIQRLHDFMWVQPEGMLMRGTNGLQVWETSFTLQALVESGLYEKEAFKPDIA 120
Query: 416 RSFKFLCRSQFTEDCVEGSFRDKRLGAWPFSTKTQGYTVSDCTAEAIKAIIMVLNSDKYR 475
++ +FL R Q +R LGAWPFS TQGYTVSD T+EA++A+++V + +
Sbjct: 121 KALEFLDRQQIRTQYEGSGYRYNSLGAWPFSNITQGYTVSDTTSEALRAVLLVQSLPDFE 180
Query: 476 DVWGVYDTEKLKNGIDVLLGLQNLSSFEYGSFATYEKIKAPLLMEKLNPAEVFGNIMVEF 535
+ D +L+ +DV+LG+QN E FA+YE + ME LNPAEVFGNIMVE+
Sbjct: 181 KL---VDIPRLRLSVDVILGMQN----ENLGFASYEPARTGEWMELLNPAEVFGNIMVEY 233
Query: 536 PYVECTDSSVLGLTYFRRYF-NYRKKDIDHAIDSAIAYIKKSQQPNGSWYGCWGICYTYA 594
Y ECT S +L L F +Y YR+ +I++ I++A+ Y+ K Q+P+GSWYG W IC+TYA
Sbjct: 234 SYPECTTSVILALRAFTKYDPGYRRDEIENTIENALEYVVKMQRPDGSWYGSWAICFTYA 293
Query: 595 GMFALEALNTIGETYENSEVVRKGCDFFVTKQLPDGGWSEKMKSSELHTYVSDKESYVVQ 654
MFA +L + G YEN V +K C+F ++KQ PDGGWSE + Y + S V Q
Sbjct: 294 AMFATGSLASAGRYYENCPVQKKACEFLLSKQRPDGGWSESYMACVTGVYTETESSLVTQ 353
Query: 655 TAWVLIGLILAKFPDKSVIDRAINLLKQRQQPSGEWKYEAVEGVFNHSCAIEYPSYRFLF 714
T W L LI AK+PD+ I++ I L Q+ G W+ +++EG+FN + AI YP+Y+ F
Sbjct: 354 TGWALDALINAKYPDRKPIEKGIKFLMASQKSDGSWQQKSMEGIFNKNVAIAYPNYKLYF 413
Query: 715 PIKALGLYVKEYGH 728
I LG + K+YG+
Sbjct: 414 SIYTLGKFAKQYGN 427
>At1g66960 [I] KOG0497 Oxidosqualene-lanosterol cyclase and related proteins
Length = 763
Score = 365 bits (938), Expect = e-100
Identities = 239/746 (32%), Positives = 372/746 (49%), Gaps = 61/746 (8%)
Query: 26 LGRQTWEY-------------------LSENDSKKVPQS--TFARWLLKCEDFPEPHPEI 64
+GRQTWE+ +N S+ P S + LK F + P +
Sbjct: 23 VGRQTWEFDPKAGTREERTAVEEARRSFFDNRSRVKPSSDLLWKMQFLKEAKFEQVIPPV 82
Query: 65 ----NSKTSGFTAWNAAHNGAKFFELLQDPDSGTFPCQYKGPMFMTIGYVVTMYIA---- 116
+ A NA G F LQ D G +P ++ GP+ M V +YI
Sbjct: 83 KIDGGEAITYEKATNALRRGVAFLSALQASD-GHWPGEFTGPLCMLPPLVFCLYITGHLE 141
Query: 117 KIEIPEHEKAEMIRYVANYAHP-VDGGWGLHHVDKSTVLGTVLNYVMMRLLGLPKD---H 172
++ EH K EM+RY+ Y H DGGWG H KS + T LNY+ +R+LG+ D
Sbjct: 142 EVFDAEHRK-EMLRYI--YCHQNEDGGWGFHIESKSIMFTTTLNYICLRILGVGPDGGLE 198
Query: 173 EVCVRARDTLLRLGGAIASPHWAKIWLSILNLYKWEGVNPAPPELWMLPYGLNIHPARWW 232
C RAR +L GG I P W K+WLS+L +Y W GVNP PPE+W+LPY L IH + +
Sbjct: 199 NACKRARQWILSHGGVIYIPCWGKVWLSVLGIYDWSGVNPMPPEIWLLPYFLPIHLGKAF 258
Query: 233 VHTRGIYLPVSYLSSTQYSCELDPLLEEIRTEIYTQPFETIDFKKHRNTVCGVDLYYPHT 292
+TR Y+P+SYL ++ ++ PL+ ++R E++ QP+E I++ K R+ D YYPH
Sbjct: 259 SYTRITYMPISYLYGKKFVGQITPLIMQLREELHLQPYEEINWNKARHLCAKEDKYYPHP 318
Query: 293 KVLDTMNYFISKYERYVRPNW-----LLKKSTNRVYELVKKEIANTDYLCIAPVNNAFCA 347
V D + + + + +W + KK+ + + E N+ Y+ I + C
Sbjct: 319 LVQDLIWDALHTFVEPLLASWPINKLVRKKALQVAMKHIHYEDENSHYITIGCIEKNLCM 378
Query: 348 IVTLIEEGKDSEEFGRFLYRFKDVLFHGPQGLTVMGTNGVQVWDCAFYIQYMFMAGLAEL 407
+ I + D F + L R D+++ G+ M G Q+W F +Q + + +
Sbjct: 379 LACWI-DNPDGNHFKKHLSRIPDMMWVAEDGMK-MQCFGSQLWMTGFAVQALLASDPRD- 435
Query: 408 PEFHETIVRSFKFLCRSQFTED---CVEGSFRDKRLGAWPFSTKTQGYTVSDCTAEAIKA 464
E ++ + R+ ++ +SQ ++ + +R G W S + G+ VSDCTAEA K
Sbjct: 436 -ETYDVLRRAHDYIKKSQVRDNPSGDFKSMYRHISKGGWTLSDRDHGWQVSDCTAEAAKC 494
Query: 465 IIMVLNSDKYRDVWG-VYDTEKLKNGIDVLLGLQNLSSFEYGSFATYEKIKAPLLMEKLN 523
+++ S D+ G + E+L + ++++L LQ+ E G F +E ++A ME +N
Sbjct: 495 CMLL--STMPTDITGEKINLEQLYDSVNLMLSLQS----ENGGFTAWEPVRAYKWMELMN 548
Query: 524 PAEVFGNIMVEFPYVECTDSSVLGLTYFRR-YFNYRKKDIDHAIDSAIAYIKKSQQPNGS 582
P ++F N M E Y ECT + + L F + Y ++R K+I +I+ A+ +I+ Q +GS
Sbjct: 549 PTDLFANAMTEREYTECTSAVLQALVIFNQLYPDHRTKEITKSIEKAVQFIESKQLRDGS 608
Query: 583 WYGCWGICYTYAGMFALEALNTIGETYENSEVVRKGCDFFVTKQLPDGGWSEKMKSSELH 642
WYG WGIC+TY FAL L IG+TY N +R G F + Q DGGW E S
Sbjct: 609 WYGSWGICFTYGTWFALCGLAAIGKTYNNCLSMRDGVHFLLNIQNEDGGWGESYMSCPEQ 668
Query: 643 TYV--SDKESYVVQTAWVLIGLILAKFPDKSVI--DRAINLLKQRQQPSGEWKYEAVEGV 698
Y+ S VVQTAW ++ LI A + +I A + Q +G++ + + G
Sbjct: 669 RYIPLEGNRSNVVQTAWAMMALIHAGQAKRDLIPLHSAAKFIITSQLENGDFPQQELLGA 728
Query: 699 FNHSCAIEYPSYRFLFPIKALGLYVK 724
+C + Y +Y+ +FP AL Y K
Sbjct: 729 SMSTCMLHYSTYKDIFPPWALAEYRK 754
>At5g48010 [I] KOG0497 Oxidosqualene-lanosterol cyclase and related proteins
Length = 769
Score = 341 bits (875), Expect = 2e-93
Identities = 217/678 (32%), Positives = 347/678 (51%), Gaps = 40/678 (5%)
Query: 73 AWNAAHNGAKFFELLQDPDSGTFPCQYKGPMFMTIGYVVTMYIA----KIEIPEHEKAEM 128
A A G +F LQ D G +P + GP F T +++ +YI KI PEH K E+
Sbjct: 95 AKTALKRGLLYFTALQ-ADDGHWPAENSGPNFYTPPFLICLYITGHLEKIFTPEHVK-EL 152
Query: 129 IRYVANYAHPVDGGWGLHHVDKSTVLGTVLNYVMMRLLGLPKDHEV----CVRARDTLLR 184
+R++ N + DGGWGLH S + TV+NYV +R++G H+ C +A ++
Sbjct: 153 LRHIYNMQNE-DGGWGLHVESHSVMFCTVINYVCLRIVGEEVGHDDQRNGCAKAHKWIMD 211
Query: 185 LGGAIASPHWAKIWLSILNLYKWEGVNPAPPELWMLPYGLNIHPARWWVHTRGIYLPVSY 244
GGA +P K LS+L +Y W G NP PPE W+LP ++ W++ R ++ +SY
Sbjct: 212 HGGATYTPLIGKALLSVLGVYDWSGCNPIPPEFWLLPSSFPVNGGTLWIYLRDTFMGLSY 271
Query: 245 LSSTQYSCELDPLLEEIRTEIYTQPFETIDFKKHRNTVCGVDLYYPHTKVLDTMNYFISK 304
L ++ PL+ ++R E+Y +P+ I++ + RN DLYYP + + D +
Sbjct: 272 LYGKKFVAPPTPLILQLREELYPEPYAKINWTQTRNRCGKEDLYYPRSFLQDLFWKSVHM 331
Query: 305 YERYVRPNWLLKK-----STNRVYELVKKEIANTDYL---CIAPVNNAFCAIVTLIEEGK 356
+ + W L K + L+ +T Y+ C+ V AF + IE+ K
Sbjct: 332 FSESILDRWPLNKLIRQRALQSTMALIHYHDESTRYITGGCLPKVVVAFHMLACWIEDPK 391
Query: 357 DSEEFGRFLYRFKDVLFHGPQGLTVMGTNGVQVWDCAFYIQYMFMAGLAEL---PEFHET 413
S+ F + L R ++ ++ G GL + + G Q+WD A + + + G+ + E T
Sbjct: 392 -SDYFKKHLARVREYIWIGEDGLKIQ-SFGSQLWDTALSL-HALLDGIDDHDVDDEIKTT 448
Query: 414 IVRSFKFLCRSQFTEDCVEGS----FRDKRLGAWPFSTKTQGYTVSDCTAEAIKAIIMVL 469
+V+ + +L +SQ TE+ G FR K G W FS + QG+ VSDCTAE+++ +
Sbjct: 449 LVKGYDYLKKSQITEN-PRGDHFKMFRHKTKGGWTFSDQDQGWPVSDCTAESLECCLF-F 506
Query: 470 NSDKYRDVWGVYDTEKLKNGIDVLLGLQNLSSFEYGSFATYEKIKAPLLMEKLNPAEVFG 529
S + D EKL + +D LL LQ+ + G A ++ ++ +E L+P E
Sbjct: 507 ESMPSELIGKKMDVEKLYDAVDYLLYLQS----DNGGIAAWQPVEGKAWLEWLSPVEFLE 562
Query: 530 NIMVEFPYVECTDSSVLGLTYFRRYF-NYRKKDIDHAIDSAIAYIKKSQQPNGSWYGCWG 588
+ +VE+ YVECT S++ LT F + F Y+ ++ I A YI+ Q +GSWYG WG
Sbjct: 563 DTIVEYEYVECTGSAIAALTQFNKQFPGYKNVEVKRFITKAAKYIEDMQTVDGSWYGNWG 622
Query: 589 ICYTYAGMFALEALNTIGETYENSEVVRKGCDFFVTKQLPDGGWSEKMKS--SELHTYVS 646
+C+ Y FA+ L G+TY N E +RK F + Q P+GGW E S S+ +T +
Sbjct: 623 VCFIYGTFFAVRGLVAAGKTYSNCEAIRKAVRFLLDTQNPEGGWGESFLSCPSKKYTPLK 682
Query: 647 DKESYVVQTAWVLIGLILAKFPDKS--VIDRAINLLKQRQQPSGEWKYEAVEGVFNHSCA 704
+ VVQTA L+ LI+ ++ + RA +L Q +G++ + + G F +
Sbjct: 683 GNSTNVVQTAQALMVLIMGDQMERDPLPVHRAAQVLINSQLDNGDFPQQEIMGTFMRTVM 742
Query: 705 IEYPSYRFLFPIKALGLY 722
+ +P+YR F + AL Y
Sbjct: 743 LHFPTYRNTFSLWALTHY 760
>At1g78500 [I] KOG0497 Oxidosqualene-lanosterol cyclase and related proteins
Length = 767
Score = 340 bits (873), Expect = 3e-93
Identities = 229/747 (30%), Positives = 372/747 (49%), Gaps = 59/747 (7%)
Query: 27 GRQTWEY---------LSENDSKK----VPQSTFA-----RW---LLKCEDFPEPHPEIN 65
GRQTWE+ L+E D + + +S F W L+ + F + P +
Sbjct: 24 GRQTWEFDADACSPEELAEVDEARQNFSINRSRFKISADLLWRMQFLREKKFEQKIPRVE 83
Query: 66 ----SKTSGFTAWNAAHNGAKFFELLQDPDSGTFPCQYKGPMFMTIGYVVTMYIA----K 117
+ A A G +F+ LQ D G +P + G +F +V+ +YI K
Sbjct: 84 IGDAENITYKDAKTALRRGILYFKALQAED-GHWPAENSGCLFFEAPFVICLYITGHLEK 142
Query: 118 IEIPEHEKAEMIRYVANYAHPVDGGWGLHHVDKSTVLGTVLNYVMMRLLGLPKDHEV--- 174
I EH K E++RY+ N+ + DGGWG+H +S + TV+NY+ +R+LG+ D +
Sbjct: 143 ILTLEHRK-ELLRYMYNHQNE-DGGWGIHVEGQSAMFCTVINYICLRILGVEADLDDIKG 200
Query: 175 --CVRARDTLLRLGGAIASPHWAKIWLSILNLYKWEGVNPAPPELWMLPYGLNIHPARWW 232
C RAR +L GGA +P K WLSIL +Y W G P PPE+WMLP + W
Sbjct: 201 SGCARARKWILDHGGATYTPLIGKAWLSILGVYDWSGCKPIPPEVWMLPTFSPFNGGTLW 260
Query: 233 VHTRGIYLPVSYLSSTQYSCELDPLLEEIRTEIYTQPFETIDFKKHRNTVCGVDLYYPHT 292
++ R I++ VSYL ++ PL+ ++R E+Y QP++ I + + RN DLYYP +
Sbjct: 261 IYFRDIFMGVSYLYGKKFVATPTPLILQLREELYPQPYDKILWSQARNQCAKEDLYYPQS 320
Query: 293 KVLDTMNYFISKYERYVRPNW-----LLKKSTNRVYELVKKEIANTDYLCIAPVNNAFCA 347
+ + + + W + +K+ EL+ + + Y V F
Sbjct: 321 FLQEMFWKCVHILSENILNRWPCNKLIRQKALRTTMELLHYQDEASRYFTGGCVPKPFHM 380
Query: 348 IVTLIEEGKDSEEFGRFLYRFKDVLFHGPQGLTVMGTNGVQVWDCAFYIQYM--FMAGLA 405
+ +E+ D + F + L R D ++ G GL + + G Q+WD AF +Q M +
Sbjct: 381 LACWVED-PDGDYFKKHLARVPDYIWIGEDGLKIQ-SFGSQLWDTAFSLQVMLAYQDVDD 438
Query: 406 ELPEFHETIVRSFKFLCRSQFTEDCV---EGSFRDKRLGAWPFSTKTQGYTVSDCTAEAI 462
+ E T+++ + FL +SQ T++ +D G W FS + QG+ VSDCTAE++
Sbjct: 439 DDDEIRSTLIKGYSFLNKSQLTQNPPGDHRKMLKDIAKGGWTFSDQDQGWPVSDCTAESL 498
Query: 463 KAIIMVLNSDKYRDVWGVYDTEKLKNGIDVLLGLQNLSSFEYGSFATYEKIKAPLLMEKL 522
+ +V S + D E+L + +++LL Q+ + G +E + +E L
Sbjct: 499 EC-CLVFGSMPSELIGEKMDVERLYDAVNLLLYFQS----KNGGITVWEAARGRTWLEWL 553
Query: 523 NPAEVFGNIMVEFPYVECTDSSVLGLTYFRRYF-NYRKKDIDHAIDSAIAYIKKSQQPNG 581
+P E + +VE YVECT S+++ L F + F +R+++++ I +A+ YI+ Q P+G
Sbjct: 554 SPVEFMEDTIVEHEYVECTGSAIVALARFLKEFPEHRREEVEKFIKNAVKYIESFQMPDG 613
Query: 582 SWYGCWGICYTYAGMFALEALNTIGETYENSEVVRKGCDFFVTKQLPDGGWSEKMKS--S 639
SWYG WG+C+ Y FA+ L G+TY+N E +RK F + Q +GGW E S +
Sbjct: 614 SWYGNWGVCFMYGTFFAVRGLVAAGKTYQNCEPIRKAVQFILETQNVEGGWGESYLSCPN 673
Query: 640 ELHTYVSDKESYVVQTAWVLIGLILA--KFPDKSVIDRAINLLKQRQQPSGEWKYEAVEG 697
+ +T + + VV T L+ LI+ D + RA +L Q +G++ E + G
Sbjct: 674 KKYTLLEGNRTNVVNTGQALMVLIMGGQMERDPLPVHRAAKVLINSQLDNGDFPQEEIMG 733
Query: 698 VFNHSCAIEYPSYRFLFPIKALGLYVK 724
VF + + Y +YR +F + AL Y K
Sbjct: 734 VFKMNVMVHYATYRNIFTLWALTYYTK 760
>At5g42600 [I] KOG0497 Oxidosqualene-lanosterol cyclase and related proteins
Length = 761
Score = 332 bits (850), Expect = 2e-90
Identities = 230/743 (30%), Positives = 355/743 (46%), Gaps = 61/743 (8%)
Query: 27 GRQTWEYLSENDS---------------------KKVPQSTFARWLLKCEDFPEPHPEIN 65
GRQ WE+ + S K P + R L+ + F + P +
Sbjct: 24 GRQIWEFDANGGSPEELAEVEEARLNFANNKSRFKASPDLFWRRQFLREKKFEQKIPRVR 83
Query: 66 ----SKTSGFTAWNAAHNGAKFFELLQDPDSGTFPCQYKGPMFMTIGYVVTMYIA----K 117
K + A A G ++ Q D G +P + G MF+ +V+ +YI K
Sbjct: 84 IEDAEKITYEDAKTALRRGVLYYAACQAND-GHWPSEVSGSMFLDAPFVICLYITGHLEK 142
Query: 118 IEIPEHEKAEMIRYVANYAHPVDGGWGLHHVDKSTVLGTVLNYVMMRLLGLPKDHE---- 173
I EH K E++RY+ N + DGGWGL S + TVLNY+ +R+LG+ DH+
Sbjct: 143 IFTLEHVK-ELLRYMYNTQNE-DGGWGLDVESHSVMFCTVLNYICLRILGVEPDHDGQKS 200
Query: 174 VCVRARDTLLRLGGAIASPHWAKIWLSILNLYKWEGVNPAPPELWMLPYGLNIHPARWWV 233
C RAR +L GGA +P AK WLS+L +Y W G P PPE+WMLP I+ W+
Sbjct: 201 ACARARKWILDHGGATYAPMVAKAWLSVLGVYDWSGCKPLPPEIWMLPSFSPINGGTLWI 260
Query: 234 HTRGIYLPVSYLSSTQYSCELDPLLEEIRTEIYTQPFETIDFKKHRNTVCGVDLYYPHTK 293
+ R + + +SYL ++ L+ ++R E+Y QP+ I + K RN DL YP +
Sbjct: 261 YIRDLLMGMSYLYGKKFVATPTALILQLREELYPQPYSKIIWSKARNRCAKEDLLYPKSF 320
Query: 294 VLDTMNYFISKYERYVRPNWLLKK-----STNRVYELVKKEIANTDYLCIAPVNNAFCAI 348
D + + W L K + ELV T Y+ A V F +
Sbjct: 321 GQDLFWEGVHMLSENIINRWPLNKFVRQRALRTTMELVHYHDETTHYITGACVAKPFHML 380
Query: 349 VTLIEEGKDSEEFGRFLYRFKDVLFHGPQGLTVMGTNGVQVWDCAFYIQYMFMAGLAELP 408
+E+ D + F + L R D ++ GL G+Q W+ A +Q M A + +
Sbjct: 381 ACWVED-PDGDYFKKHLARVPDFIWIAEDGLKFQ-LMGMQSWNAALSLQVMLAANMDD-- 436
Query: 409 EFHETIVRSFKFLCRSQFTEDCVEGS----FRDKRLGAWPFSTKTQGYTVSDCTAEAIKA 464
E T+++ + FL +SQ +E+ +G FRD G W F + QG +SD TAE+I+
Sbjct: 437 EIRSTLIKGYDFLKQSQISEN-PQGDHLKMFRDITKGGWTFQDREQGLPISDGTAESIEC 495
Query: 465 IIMVLNSDKYRDVWGVYDTEKLKNGIDVLLGLQNLSSFEYGSFATYEKIKAPLLMEKLNP 524
I + + D EKL + ++ L+ LQ+ + G +E +E L+P
Sbjct: 496 CIH-FHRMPSEFIGEKMDVEKLYDAVNFLIYLQS----DNGGMPVWEPAPGKKWLEWLSP 550
Query: 525 AEVFGNIMVEFPYVECTDSSVLGLTYFRRYF-NYRKKDIDHAIDSAIAYIKKSQQPNGSW 583
E N +VE Y+ECT S + GL F++ F ++R K+I+ I + YI+ Q P+GSW
Sbjct: 551 VEHVENTVVEQEYLECTGSVIAGLVCFKKEFPDHRPKEIEKLIKKGLKYIEDLQMPDGSW 610
Query: 584 YGCWGICYTYAGMFALEALNTIGETYENSEVVRKGCDFFVTKQLPDGGWSEKMKSSELHT 643
YG WG+C+TY +FA+ L G+T+ NSE +R+ F + Q +GGW E S
Sbjct: 611 YGNWGVCFTYGTLFAVRGLAAAGKTFGNSEAIRRAVQFILNTQNAEGGWGESALSCPNKK 670
Query: 644 YVSDKESY--VVQTAWVLIGLILA--KFPDKSVIDRAINLLKQRQQPSGEWKYEAVEGVF 699
Y+ K + VV T ++ L++ D S + RA +L Q G++ + G++
Sbjct: 671 YIPSKGNVTNVVNTGQAMMVLLIGGQMERDPSPVHRAAKVLINSQLDIGDFPQQERRGIY 730
Query: 700 NHSCAIEYPSYRFLFPIKALGLY 722
+ + YP+YR +F + AL LY
Sbjct: 731 -MNMLLHYPTYRNMFSLWALALY 752
>At4g15370 [I] KOG0497 Oxidosqualene-lanosterol cyclase and related proteins
Length = 759
Score = 327 bits (838), Expect = 4e-89
Identities = 223/749 (29%), Positives = 356/749 (46%), Gaps = 67/749 (8%)
Query: 26 LGRQTWEY---------LSE---------NDSKKVPQSTFARW---LLKCEDFPEPHPEI 64
+GRQ WE+ L+E N+ + S W L+ + F + P +
Sbjct: 23 VGRQIWEFDANAGSPEELAEVEEARRNFSNNRSRFKASADLLWRMQFLREKKFEQKIPRV 82
Query: 65 ----NSKTSGFTAWNAAHNGAKFFELLQDPDSGTFPCQYKGPMFMTIGYVVTMYIA---- 116
K + A A G +F LQ D G +P + G +F +V+ +YI
Sbjct: 83 IVEDAEKITYEDAKTALRRGLLYFTALQ-ADDGHWPAENAGSIFFNAPFVICLYITGHLE 141
Query: 117 KIEIPEHEKAEMIRYVANYAHPVDGGWGLHHVDKSTVLGTVLNYVMMRLLGLPKDHE--- 173
KI EH + E++RY+ N+ + DGGWGLH S + +V+NY+ +R+LG+ H+
Sbjct: 142 KIFTHEH-RVELLRYMYNHQNE-DGGWGLHVESPSNMFCSVINYICLRILGVEAGHDDKG 199
Query: 174 -VCVRARDTLLRLGGAIASPHWAKIWLSILNLYKWEGVNPAPPELWMLPYGLNIHPARWW 232
C RAR +L GGA SP K WLS+L +Y W G P PPE W LP ++ W
Sbjct: 200 SACARARKWILDHGGATYSPLIGKAWLSVLGVYDWSGCKPIPPEFWFLPSFFPVNGGTLW 259
Query: 233 VHTRGIYLPVSYLSSTQYSCELDPLLEEIRTEIYTQPFETIDFKKHRNTVCGVDLYYPHT 292
++ R I++ +SYL + PL+ ++R EIY +P+ I +++ RN DLYYP +
Sbjct: 260 IYLRDIFMGLSYLYGKNFVATSTPLILQLREEIYPEPYTNISWRQARNRCAKEDLYYPQS 319
Query: 293 KVLDTMNYFISKYERYVRPNW-----LLKKSTNRVYELVKKEIANTDYLCIAPVNNAFCA 347
+ D + + + W + +++ ELV T Y+ V
Sbjct: 320 FLQDLFWKGVHVFSENILNRWPFNNLIRQRALRTTMELVHYHDEATRYITGGSVPKVIAV 379
Query: 348 IVTLI--EEGKDSEEFGRFLYRFKDVLFHGPQGLTVMGTNGVQVWDCAFYIQYMFMAGLA 405
L E +S+ F + L R D ++ G GL + + G QVWD A + ++F+ G
Sbjct: 380 FHMLACWVEDPESDYFKKHLARVPDFIWIGEDGLKIQ-SFGSQVWDTALSL-HVFIDGFD 437
Query: 406 E--LPEFHETIVRSFKFLCRSQFTED---CVEGSFRDKRLGAWPFSTKTQGYTVSDCTAE 460
+ E T+++ + +L +SQ TE+ FR G W FS + QG+ VSDCTAE
Sbjct: 438 DDVDEEIRSTLLKGYDYLEKSQVTENPPGDYMKMFRHMAKGGWTFSDQDQGWPVSDCTAE 497
Query: 461 AIKAIIMVLNSDKYRDVWGVYDTEKLKNGIDVLLGLQNLSSFEYGSFATYEKIKAPLLME 520
+++ + S + D EKL + +D LL LQ+ + G ++ L+
Sbjct: 498 SLECCLF-FESMSSEFIGKKMDVEKLYDAVDFLLYLQS----DNGGITAWQPADGKLV-- 550
Query: 521 KLNPAEVFGNIMVEFPYVECTDSSVLGLTYFRRYF-NYRKKDIDHAIDSAIAYIKKSQQP 579
E + +VE YVECT S+++ L F + F Y+K++++ I + YI+ Q
Sbjct: 551 -----EFIEDAVVEHEYVECTGSAIVALAQFNKQFPGYKKEEVERFITKGVKYIEDLQMV 605
Query: 580 NGSWYGCWGICYTYAGMFALEALNTIGETYENSEVVRKGCDFFVTKQLPDGGWSEKMKSS 639
+GSWYG WG+C+ Y FA+ L G+ Y N E +R+ F + Q +GGW E S
Sbjct: 606 DGSWYGNWGVCFIYGTFFAVRGLVAAGKCYNNCEAIRRAVRFILDTQNTEGGWGESYLSC 665
Query: 640 ELHTYVS--DKESYVVQTAWVLIGLILAK--FPDKSVIDRAINLLKQRQQPSGEWKYEAV 695
Y+ ++ VV T L+ LI+ D + RA +L Q +G++ + +
Sbjct: 666 PRKKYIPLIGNKTNVVNTGQALMVLIMGNQMKRDPLPVHRAAKVLINSQMDNGDFPQQEI 725
Query: 696 EGVFNHSCAIEYPSYRFLFPIKALGLYVK 724
GVF + + +P+YR +F + AL Y K
Sbjct: 726 MGVFKMNVMLHFPTYRNMFTLWALTHYTK 754
>At5g36150 [I] KOG0497 Oxidosqualene-lanosterol cyclase and related proteins
Length = 729
Score = 318 bits (814), Expect = 2e-86
Identities = 208/710 (29%), Positives = 339/710 (47%), Gaps = 57/710 (8%)
Query: 26 LGRQTWEY---------LSENDSKKVPQSTFARWLLKCEDF----------------PEP 60
LGRQ WE+ LSE D + S C D P
Sbjct: 23 LGRQIWEFDANAGSPAELSEVDQARQNFSNNRSQYKACADLLWRMQFLREKNFEQKIPRV 82
Query: 61 HPEINSKTSGFTAWNAAHNGAKFFELLQDPDSGTFPCQYKGPMFMTIGYVVTMYIA---- 116
E K + A N G + LQ D G +P + G +F +V+ +YI
Sbjct: 83 RIEDAKKITFEDAKNTLRRGIHYMAALQS-DDGHWPSENAGCIFFNAPFVICLYITGHLD 141
Query: 117 KIEIPEHEKAEMIRYVANYAHPVDGGWGLHHVDKSTVLGTVLNYVMMRLLGLPKDHE--- 173
K+ EH K EM+RY+ N+ + DGGWG+ S + TV+NY+ +R+ G+ DH+
Sbjct: 142 KVFSEEHRK-EMLRYMYNHQND-DGGWGIDVESHSFMFCTVINYICLRIFGVDPDHDGES 199
Query: 174 VCVRARDTLLRLGGAIASPHWAKIWLSILNLYKWEGVNPAPPELWMLPYGLNIHPARWWV 233
C RAR ++ GGA +P + K WLS+L +Y+W G P PPE W P I+ W+
Sbjct: 200 ACARARKWIIDHGGATYTPLFGKAWLSVLGVYEWSGCKPIPPEFWFFPSYFPINGGTLWI 259
Query: 234 HTRGIYLPVSYLSSTQYSCELDPLLEEIRTEIYTQPFETIDFKKHRNTVCGVDLYYPHTK 293
+ R ++ +SYL ++ + PL+ ++R E+Y QP+ I + + R+ DLYYP +
Sbjct: 260 YLRDTFMAMSYLYGKKFVAKPTPLILQLREELYPQPYAEIVWSQARSRCAKEDLYYPQSL 319
Query: 294 VLDTMNYFISKYERYVRPNW-----LLKKSTNRVYELVKKEIANTDYLCIAPVNNAFCAI 348
V D + + + W + +K+ EL+ T Y+ V F +
Sbjct: 320 VQDLFWKLVHMFSENILNRWPFNKLIREKAIRTAMELIHYHDEATRYITGGAVPKVFHML 379
Query: 349 VTLIEEGKDSEEFGRFLYRFKDVLFHGPQGLTVMGTNGVQVWDCAFYIQYMFMAGLAELP 408
+E+ +S+ F + L R ++ GL + T G Q+WD AF +Q M A + +
Sbjct: 380 ACWVED-PESDYFKKHLARVSHFIWIAEDGLKIQ-TFGSQIWDTAFVLQVMLAADVDD-- 435
Query: 409 EFHETIVRSFKFLCRSQFTED---CVEGSFRDKRLGAWPFSTKTQGYTVSDCTAEAIKAI 465
E T+++ + +L +SQFTE+ FRD G W +S K QG+ VSDC +E+++
Sbjct: 436 EIRPTLIKGYSYLRKSQFTENPPGDYINMFRDISKGGWGYSDKDQGWPVSDCISESLEC- 494
Query: 466 IMVLNSDKYRDVWGVYDTEKLKNGIDVLLGLQNLSSFEYGSFATYEKIKAPLLMEKLNPA 525
++ S + + E+L + +++LL +Q+ + G + +E +E L+P
Sbjct: 495 CLIFESMSSEFIGEKMEVERLYDAVNMLLYMQSRN----GGISIWEAASGKKWLEWLSPI 550
Query: 526 EVFGNIMVEFPYVECTDSSVLGLTYFRRYF-NYRKKDIDHAIDSAIAYIKKSQQPNGSWY 584
E + ++E Y+ECT S+++ L F + F +R +++ I + YI+ Q +GSWY
Sbjct: 551 EFIEDTILEHEYLECTGSAIVVLARFMKQFPGHRTEEVKKFITKGVKYIESLQIADGSWY 610
Query: 585 GCWGICYTYAGMFALEALNTIGETYENSEVVRKGCDFFVTKQLPDGGWSEKMKSSELHTY 644
G WGIC+ Y FA+ L G TY+N E +R+ F + Q +GGW E S Y
Sbjct: 611 GNWGICFIYGTFFAVRGLVAAGNTYDNCEAIRRAVRFLLDIQNGEGGWGESFLSCPNKNY 670
Query: 645 V--SDKESYVVQTAWVLIGLILAKFPDKS--VIDRAINLLKQRQQPSGEW 690
+ ++ VV T L+ LI+ D+ + RA +L Q +G++
Sbjct: 671 IPLEGNKTDVVNTGQALMVLIMGGQMDRDPLPVHRAAKVLINSQMDNGDF 720
>SPAC13G7.01c [I] KOG0497 Oxidosqualene-lanosterol cyclase and related proteins
Length = 309
Score = 276 bits (705), Expect = 1e-73
Identities = 133/314 (42%), Positives = 195/314 (61%), Gaps = 13/314 (4%)
Query: 2 PELYSETIGLPRTDPKRWRLITDDLGRQTWEYLSENDSKKVPQSTFARWLLKCE-DFPEP 60
PEL S+T+ + D WRL D G +TWEY+++ +++K P + ++ L + D P+
Sbjct: 8 PEL-SKTV--EQIDKSLWRLNIDSAGGETWEYVTKEEAEKRPLTIAEKYFLGFDLDLPKR 64
Query: 61 HPEINSKTSGFTAWNAAHNGAKFFELLQDPDSGTFPCQYKGPMFMTIGYVVTMYIAKIEI 120
P T +A G +FF LQ PD G + Y+GPMF+ G V YI++
Sbjct: 65 PP-------AKTPLESAEYGYEFFRRLQLPD-GHWASPYEGPMFLICGAVFAFYISQTPF 116
Query: 121 PEHEKAEMIRYVANYAHPVDGGWGLHHVDKSTVLGTVLNYVMMRLLGLPKDHEVCVRARD 180
P+ E+I+Y+ N+ + DGGWG+H STV GT +NYV++R+LG+ H V RAR+
Sbjct: 117 PKGWAPEIIQYLINHTND-DGGWGIHTEGVSTVFGTSMNYVVLRILGMDAGHPVATRARN 175
Query: 181 TLLRLGGAIASPHWAKIWLSILNLYKWEGVNPAPPELWMLPYGLNIHPARWWVHTRGIYL 240
L LGGAI PHW K WL+ LN Y W+GVNP PPELW+LP + HP +WW H R +YL
Sbjct: 176 RLHELGGAIGCPHWGKFWLATLNCYDWDGVNPIPPELWLLPDWIPFHPGKWWCHVRLVYL 235
Query: 241 PVSYLSSTQYSCELDPLLEEIRTEIYTQPFETIDFKKHRNTVCGVDLYYPHTKVLDTMNY 300
P+ Y+ + C D L+ ++R E+Y + +++I+F HRNT+ VDLY+PHT++LD +N+
Sbjct: 236 PMGYMYGERLKCPKDSLIMQLRKELYVENYDSINFADHRNTISDVDLYFPHTQILDRLNW 295
Query: 301 FISKYERYVRPNWL 314
+ KY Y+RP+WL
Sbjct: 296 ILEKYFTYLRPSWL 309
>At4g15340 [I] KOG0497 Oxidosqualene-lanosterol cyclase and related proteins
Length = 760
Score = 263 bits (671), Expect = 9e-70
Identities = 193/693 (27%), Positives = 320/693 (45%), Gaps = 73/693 (10%)
Query: 55 EDFPEPHPEINSKTSGFTAWNAAHNGAKFFELLQDPDSGTFPCQYKGPMFMTIGYVVTMY 114
+ P E +K A A G +F LQ D G +P GP F V+ +Y
Sbjct: 77 QKIPRVRVEDAAKIRYEDAKTALKRGLHYFTALQ-ADDGHWPADNSGPNFFIAPLVICLY 135
Query: 115 IA----KIEIPEHEKAEMIRYVANYAHPVDGGWGLHHVDKSTVLGTVLNYVMMRLLGLPK 170
I KI EH + E+IRY+ N+ + DGGWGLH S + TV+NY+ +R++G+
Sbjct: 136 ITGHLEKIFTVEH-RIELIRYMYNHQNE-DGGWGLHVESPSIMFCTVINYICLRIVGVEA 193
Query: 171 DHE-----VCVRARDTLLRLGGAIASPHWAKIWLSILNLYKWEGVNPAPPELWMLPYGLN 225
H+ C +AR +L GGA +P K LS+L +Y W G P PPE W LP
Sbjct: 194 GHDDDQGSTCTKARKWILDHGGATYTPLIGKACLSVLGVYDWSGCKPMPPEFWFLPSSFP 253
Query: 226 IHPARWWVHTRGIYLPVSYLSSTQYSCELDPLLEEIRTEIYTQPFETIDFKKHRNTVCGV 285
I+ W++ R I++ +SYL ++ PL+ +++ E+Y +P+ I+++ RN
Sbjct: 254 INGGTLWIYLRDIFMGLSYLYGKKFVATPTPLILQLQEELYPEPYTKINWRLTRNRCAKA 313
Query: 286 D------LYYPHTKVLDTMNYF---------ISKYERYVRPNWLLKK-----STNRVYEL 325
+ Y K++ Y + + + W K + +L
Sbjct: 314 SCKYKSHVIYIRKKIVLRFMYACLILLRTACVHIFSESILNRWPFNKLIRQAALRTTMKL 373
Query: 326 VKKEIANTDYLCIAPVNNAFCAIVTLIEEGKDSEEFGRFLYRFKDVLFHGPQGLTVMGTN 385
+ + Y+ V AF + +E+ + E F + L R D ++ G GL +
Sbjct: 374 LHYQDEANRYITGGSVPKAFHMLACWVED-PEGEYFKKHLARVSDFIWIGEDGLKIQSF- 431
Query: 386 GVQVWDCAFYIQYMFMAGLAELP-EFHETIVRSFKFLCRSQFTEDCVEGS---FRDKRLG 441
G Q+WD + ++ ++ E T+V+ + +L +SQ TE+ FR G
Sbjct: 432 GSQLWDTVMSLHFLLDGVEDDVDDEIRSTLVKGYDYLKKSQVTENPPSDHIKMFRHISKG 491
Query: 442 AWPFSTKTQGYTVSDCTAEAIKAIIMVLNSDKY---------RDVWGVYDTEKLKNGIDV 492
W FS K QG+ VSDCTAE++K+ M+ ++ + V D EKL + +D
Sbjct: 492 GWTFSDKDQGWPVSDCTAESLKSKQMICSNSQCCLLFERMPSEFVGQKMDVEKLFDAVDF 551
Query: 493 LLGLQNLSSFEYGSFATYEKIKAPLLMEKLNPAEVFGNIMVEFPYVEC-----TDSSVLG 547
LL LQ+ + G +E PA+ + V F +V C S+++
Sbjct: 552 LLYLQS----DNGGITAWE------------PADGKTWLEVSFYFVICHIPLRPGSAIVA 595
Query: 548 LTYFRRYF-NYRKKDIDHAIDSAIAYIKKSQQPNGSWYGCWGICYTYAGMFALEALNTIG 606
LT F + F +RKK+++ I + + YI+ Q +GSW G WG+C+ Y +FA+ L G
Sbjct: 596 LTQFSKQFPEFRKKEVERFITNGVKYIEDLQMKDGSWCGNWGVCFIYGTLFAVRGLVAAG 655
Query: 607 ETYENSEVVRKGCDFFVTKQLPDGGWSEKMKS--SELHTYVSDKESYVVQTAWVLIGLIL 664
+T+ N E +R+ F + Q +GGW E S + +T ++ ++ +V T L+ LI+
Sbjct: 656 KTFHNCEPIRRAVRFLLDTQNQEGGWGESYLSCLRKKYTPLAGNKTNIVSTGQALMVLIM 715
Query: 665 A--KFPDKSVIDRAINLLKQRQQPSGEWKYEAV 695
D + RA ++ Q +G++ + V
Sbjct: 716 GGQMERDPLPVHRAAKVVINLQLDNGDFPQQVV 748
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.321 0.139 0.441
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 47,772,309
Number of Sequences: 60738
Number of extensions: 2175085
Number of successful extensions: 4507
Number of sequences better than 1.0e-05: 16
Number of HSP's better than 0.0 without gapping: 16
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 4362
Number of HSP's gapped (non-prelim): 25
length of query: 731
length of database: 30,389,216
effective HSP length: 114
effective length of query: 617
effective length of database: 23,465,084
effective search space: 14477956828
effective search space used: 14477956828
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)