ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactII2661 good R KOG0118 General function prediction only FOG: RRM domain
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactII2661 923125 921746 -460
(460 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YPR163c [R] KOG0118 FOG: RRM domain 323 3e-88
Hs14702180 [R] KOG0118 FOG: RRM domain 70 9e-12
SPBC18H10.04c [R] KOG0118 FOG: RRM domain 69 2e-11
Hs20539645 [R] KOG0118 FOG: RRM domain 68 3e-11
Hs11559923 [R] KOG0118 FOG: RRM domain 65 3e-10
Hs22049772 [R] KOG0118 FOG: RRM domain 57 6e-08
Hs18553603_3 [R] KOG0118 FOG: RRM domain 57 6e-08
Hs4503533 [R] KOG0118 FOG: RRM domain 57 8e-08
Hs22057414 [R] KOG0118 FOG: RRM domain 57 8e-08
Hs4505255 [A] KOG4205 RNA-binding protein musashi/mRNA cleavage ... 50 5e-06
7289885 [R] KOG0118 FOG: RRM domain 50 5e-06
>YPR163c [R] KOG0118 FOG: RRM domain
Length = 436
Score = 323 bits (829), Expect = 3e-88
Identities = 199/477 (41%), Positives = 261/477 (53%), Gaps = 58/477 (12%)
Query: 1 MAPPKKNAIKMDLSSFLEDETFNESWTADEVDLNNISIPIQNVAATNTISLDDFSRST-- 58
MAPPKK KMDL+SFL D+TF SW ++VDLN I+IPI+ A NTI L + + +
Sbjct: 1 MAPPKKTVKKMDLTSFLNDDTFGSSWAEEDVDLNKITIPIETANA-NTIPLSELAHAKNN 59
Query: 59 -----AKGSGNRFGG-GKLDPAL----RKEREEYPIPDFPPFKAIINNIPWDITEIGIQQ 108
+ G G FGG +LDPAL REEYP+PD PP++A+INNIPWDIT G+Q
Sbjct: 60 SNNTRSGGFGGSFGGRSRLDPALGGGSSDRREEYPVPDAPPYRAVINNIPWDITPEGVQA 119
Query: 109 WVEDGLNKEGAVLEVMAPRH-PDNDRLKGMAFVTFNERSDLEKALTFSSSKLNDRTVYVS 167
WVEDGL K AV EV+ P++ D RLKG AFVT ER+DL L F+ +KLN+RTVYVS
Sbjct: 120 WVEDGLVKPEAVEEVVLPKNLRDPTRLKGNAFVTLKERADLVAVLKFNGTKLNERTVYVS 179
Query: 168 VAAPRSNYGGRSNFDDMDWSGARGSNFREGGREAGPEPDWSAARGSNFRESRTREAGLEP 227
VAAPR G D+DWS ARGSNF+ GRE P+ DW AARGSNFR R ++
Sbjct: 180 VAAPRRGGGA-----DVDWSSARGSNFQGDGREDAPDLDWGAARGSNFRGPRREREEVDI 234
Query: 228 DWSSARGSNFXXXX---XXXXXXXXXDWSSARGSHFXXXXXXXXXXXXXXXXDWTSARGS 284
DW++ARGSNF DWS+ARGS+F DW++ARGS
Sbjct: 235 DWTAARGSNFQGSSRPPRREREEVDIDWSAARGSNFQGSSRPPRREREEPDIDWSAARGS 294
Query: 285 HFKXXXXXXXXXXXXDWSSARGSHFKESKPRAPEPDWSSARGSHFRDQKPRSPEPDWSDA 344
+F+ SS+R + + P+ DWS+ARGS+F+ R P
Sbjct: 295 NFQ--------------SSSRPPRREREE---PDIDWSAARGSNFQSSS-RPPR------ 330
Query: 345 RGSHFKESKQRGPDIDWSAARGTKFGRQSESTPAPKKSYSRKENAQQQKPEETPKVVKSA 404
+E ++ P +DW AARG +FG+ ++ K +Y + ++ +E PK+ KS
Sbjct: 331 -----REREKEEPALDWGAARGAQFGKPQQT----KNTYKDRSLTNKKTTDEQPKIQKSV 381
Query: 405 FAVLSXXXXXXXXXXXXXXXXXXXKTAD-DVEVLEKSTKGLSIDQDDNEEWETVGKK 460
+ VL D VE L+ T L+++ DN WE VGKK
Sbjct: 382 YDVLRTEDDDEDEEAEKQNGDAKENKVDAAVEKLQDKTAQLTVEDGDN--WEVVGKK 436
>Hs14702180 [R] KOG0118 FOG: RRM domain
Length = 228
Score = 69.7 bits (169), Expect = 9e-12
Identities = 56/181 (30%), Positives = 81/181 (43%), Gaps = 25/181 (13%)
Query: 66 FGGGKLDPAL---RKEREEYPIPDFPPFKAIINNIPWDITEIGIQQWVEDGLNKEGAVLE 122
FGGG+ R + +P PP+ A + N+P++ + I D + K+ ++
Sbjct: 15 FGGGRGSRGSAGGHGSRSQKELPTEPPYTAYVGNLPFNTVQGDI-----DAIFKDLSIRS 69
Query: 123 VMAPRHPDNDRLKGMAFVTFNERSDLEKALTFSSSKLNDRTVYVSVAAPRSNYGGRSNF- 181
V R D D+ KG +V F+E L++ALT+ + L DR++ V +A R G F
Sbjct: 70 VRLVRDKDTDKFKGFCYVEFDEVDSLKEALTYDGALLGDRSLRVDIAEGRKQDKGGFGFR 129
Query: 182 ----DDM----DWSGARGSNFREGGREAGPE-----PDWSAARGSN--FRESRTREAGLE 226
DD D+ G RG + R G R GP D RGSN FRE E
Sbjct: 130 KGGPDDRGFRDDFLGGRGGS-RPGDRRTGPPMGSRFRDGPPLRGSNMDFREPTEEERAQR 188
Query: 227 P 227
P
Sbjct: 189 P 189
>SPBC18H10.04c [R] KOG0118 FOG: RRM domain
Length = 388
Score = 68.6 bits (166), Expect = 2e-11
Identities = 56/195 (28%), Positives = 87/195 (43%), Gaps = 26/195 (13%)
Query: 4 PKKNAIKMDLSSFLEDETFNESWTADEVDLNNISIPIQNVAATNTISLDDFSRSTAKGSG 63
PKK+ KM L++FL DE+F + AD++D + + T S + S+A
Sbjct: 3 PKKST-KMSLNAFLGDESFGSTNWADDID------DLPALPQDRTTSTYRATPSSADAGY 55
Query: 64 NR----FGGGKLDPALRKE--------REEYPIPDFPPFKAIINNIPWDITEIGIQQWVE 111
N F + P R+E R+ PIP PPF A + N+ +D+TE + +
Sbjct: 56 NAPSSTFESVRSPPESRREGGMGSGYQRDAIPIPSEPPFTAHVGNLSFDLTENDLGDFFG 115
Query: 112 DGLNKEGAVLEVMAPRHPDNDRLKGMAFVTFNERSDLEKALTFSSSKLNDRTVYVSVAAP 171
+G+ V++ P +R +G +V F L AL S L R V ++VA P
Sbjct: 116 EGVTSIRLVID------PLTERSRGFGYVEFETADTLSAALALSGEDLMGRPVRITVAEP 169
Query: 172 RSNYGGRSNFDDMDW 186
R ++ R DW
Sbjct: 170 RRSF-AREERSTGDW 183
>Hs20539645 [R] KOG0118 FOG: RRM domain
Length = 228
Score = 67.8 bits (164), Expect = 3e-11
Identities = 58/192 (30%), Positives = 83/192 (43%), Gaps = 27/192 (14%)
Query: 52 DDFSRSTAKGSGNRFGGGKLDPALRKEREEYPIPDFPPFKAIINNIPWDITEIGIQQWVE 111
D S G G+R G +KE +P PP+ A + N+P++ I
Sbjct: 9 DQAYSSFGSGRGSRGSAGGHGSRSQKE-----LPTEPPYTAYVGNLPFNTVRGDI----- 58
Query: 112 DGLNKEGAVLEVMAPRHPDNDRLKGMAFVTFNERSDLEKALTFSSSKLNDRTVYVSVAAP 171
D + K+ ++ V R D D+ KG +V F+E L++ALT+ + L DR++ V +A
Sbjct: 59 DAIFKDLSIRSVRLVRDKDTDKFKGFCYVEFDEVDSLKEALTYDGALLGDRSLRVDIAEG 118
Query: 172 RSNYGGRSNF-----DDM----DWSGARGSNFREGGREAGPE-----PDWSAARGSN--F 215
R G F DD D+ G RG + R G R GP D GSN F
Sbjct: 119 RKQDKGGFGFRKGGPDDRGFRDDFLGGRGGS-RPGDRRTGPPMGSRFGDGPPLGGSNMDF 177
Query: 216 RESRTREAGLEP 227
RE E+ P
Sbjct: 178 REPTEEESAQRP 189
>Hs11559923 [R] KOG0118 FOG: RRM domain
Length = 248
Score = 64.7 bits (156), Expect = 3e-10
Identities = 56/201 (27%), Positives = 84/201 (40%), Gaps = 45/201 (22%)
Query: 66 FGGGKLDPAL---RKEREEYPIPDFPPFKAIINNIPWDITEIGIQQWVEDGLNKEGAVLE 122
FGGG+ R + +P PP+ A + N+P++ + I D + K+ ++
Sbjct: 15 FGGGRGSRGSAGGHGSRSQKELPTEPPYTAYVGNLPFNTVQGDI-----DAIFKDLSIRS 69
Query: 123 VMAPRHPDNDRLKGMAFVTFNERSDLEKALTFSSSKLNDRTVYVSVA------------- 169
V R D D+ KG +V F+E L++ALT+ + L DR++ V +A
Sbjct: 70 VRLVRDKDTDKFKGFCYVEFDEVDSLKEALTYDGALLGDRSLRVDIAEGRKQDKGGFGFR 129
Query: 170 ----------APRSNYGGRSNFDDM------DWSGARGSNFREGGREAGPE-----PDWS 208
+ R + GG + DD D+ G RG + R G R GP D
Sbjct: 130 KGGPDDRGMGSSRESRGGWDSRDDFNSGFRDDFLGGRGGS-RPGDRRTGPPMGSRFRDGP 188
Query: 209 AARGSN--FRESRTREAGLEP 227
RGSN FRE E P
Sbjct: 189 PLRGSNMDFREPTEEERAQRP 209
>Hs22049772 [R] KOG0118 FOG: RRM domain
Length = 224
Score = 57.0 bits (136), Expect = 6e-08
Identities = 31/87 (35%), Positives = 49/87 (55%), Gaps = 6/87 (6%)
Query: 84 IPDFPPFKAIINNIPWDITEIGIQQWVEDGLNKEGAVLEVMAPRHPDN-DRLKGMAFVTF 142
+P PP+ A + N+P+D+TE I+++ GLN + V PR P N +RLKG + F
Sbjct: 90 LPKSPPYTAFLGNLPYDVTEESIKEFFR-GLN----ISAVRLPREPSNPERLKGFGYAEF 144
Query: 143 NERSDLEKALTFSSSKLNDRTVYVSVA 169
+ L AL+ + L++R + V VA
Sbjct: 145 EDLDSLLSALSLNEESLSNRRIRVDVA 171
>Hs18553603_3 [R] KOG0118 FOG: RRM domain
Length = 306
Score = 57.0 bits (136), Expect = 6e-08
Identities = 40/138 (28%), Positives = 65/138 (46%), Gaps = 16/138 (11%)
Query: 84 IPDFPPFKAIINNIPWDITEIGIQQWVEDGLNKEGAVLEVMAPRHPDN-DRLKGMAFVTF 142
+P PP+ A + N+P+D+TE I++ GLN + V PR P N +RLKG + F
Sbjct: 63 LPKSPPYTAFLGNLPYDVTEESIKELFR-GLN----ISAVCLPREPSNPERLKGFGYAEF 117
Query: 143 NERSDLEKALTFSSSKLNDRTVYVSVAAPRSNYGGRSNFDDMDWSGARGSNFREGGREAG 202
++ L AL+ + L +R + V VA + + DD + R +F + +
Sbjct: 118 DDLDSLFSALSLNKESLGNRRIRVDVADRAQD----KDRDDRSFGHERNRDFDKTNTDWR 173
Query: 203 PEP------DWSAARGSN 214
P D+S RG +
Sbjct: 174 ARPVTDSLDDYSPRRGDD 191
>Hs4503533 [R] KOG0118 FOG: RRM domain
Length = 611
Score = 56.6 bits (135), Expect = 8e-08
Identities = 31/87 (35%), Positives = 48/87 (54%), Gaps = 6/87 (6%)
Query: 84 IPDFPPFKAIINNIPWDITEIGIQQWVEDGLNKEGAVLEVMAPRHPDN-DRLKGMAFVTF 142
+P PP+ A + N+P+D+TE I+++ GLN + V PR P N +RLKG + F
Sbjct: 90 LPKSPPYTAFLGNLPYDVTEESIKEFFR-GLN----ISAVRLPREPSNPERLKGFGYAEF 144
Query: 143 NERSDLEKALTFSSSKLNDRTVYVSVA 169
+ L AL+ + L +R + V VA
Sbjct: 145 EDLDSLLSALSLNEESLGNRRIRVDVA 171
>Hs22057414 [R] KOG0118 FOG: RRM domain
Length = 565
Score = 56.6 bits (135), Expect = 8e-08
Identities = 31/87 (35%), Positives = 48/87 (54%), Gaps = 6/87 (6%)
Query: 84 IPDFPPFKAIINNIPWDITEIGIQQWVEDGLNKEGAVLEVMAPRHPDN-DRLKGMAFVTF 142
+P PP+ A + N+P+D+TE I+++ GLN + V PR P N +RLKG + F
Sbjct: 90 LPKSPPYTAFLGNLPYDVTEESIKEFFR-GLN----ISAVRLPREPSNPERLKGFGYAEF 144
Query: 143 NERSDLEKALTFSSSKLNDRTVYVSVA 169
+ L AL+ + L +R + V VA
Sbjct: 145 EDLDSLLSALSLNEESLGNRRIRVDVA 171
>Hs4505255 [A] KOG4205 RNA-binding protein musashi/mRNA cleavage and
polyadenylation factor I complex subunit HRP1
Length = 362
Score = 50.4 bits (119), Expect = 5e-06
Identities = 29/90 (32%), Positives = 47/90 (52%), Gaps = 6/90 (6%)
Query: 85 PDFP--PFKAIINNIPWDITEIGIQQWVEDGLNKEGAVLEVMAPRHPDNDRLKGMAFVTF 142
PD P P K I + W T+ G++++ + G V E + R P R +G FVTF
Sbjct: 13 PDSPHDPCKMFIGGLSWQTTQEGLREY----FGQFGEVKECLVMRDPLTKRSRGFGFVTF 68
Query: 143 NERSDLEKALTFSSSKLNDRTVYVSVAAPR 172
+++ ++K L S +L+ +T+ VA PR
Sbjct: 69 MDQAGVDKVLAQSRHELDSKTIDPKVAFPR 98
>7289885 [R] KOG0118 FOG: RRM domain
Length = 507
Score = 50.4 bits (119), Expect = 5e-06
Identities = 40/158 (25%), Positives = 64/158 (40%), Gaps = 7/158 (4%)
Query: 73 PALRKEREEYPIPDFPPFKAIINNIPWDITEIGIQQWVEDGLNKEGAVLEVMAPRHP-DN 131
P + ++ IP PF A INN+P+D E + ++ E G+N ++ + PR +N
Sbjct: 258 PRANRIFDDNSIPHKAPFIAYINNLPFDANEDDLYEFFE-GIN----LISLRLPREDGEN 312
Query: 132 DRLKGMAFVTFNERSDLEKALTFSSSKLNDRTVYVSVAAPRSNYGGRSNFDDMDWSGARG 191
R +G +V R DL L+ + R + + ++ + + D G G
Sbjct: 313 GRSRGFGYVELENREDLIHVLSLPDPSIKGRRIRIELSNENDQQSRQKSNRRFDGFGNNG 372
Query: 192 SNFREGG-REAGPEPDWSAARGSNFRESRTREAGLEPD 228
N G R + SNF S RE PD
Sbjct: 373 DNRDSGNWRRDSQNNGSNFGYSSNFERSFNRERKSLPD 410
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.310 0.129 0.387
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,027,041
Number of Sequences: 60738
Number of extensions: 1134665
Number of successful extensions: 3049
Number of sequences better than 1.0e-05: 11
Number of HSP's better than 0.0 without gapping: 1
Number of HSP's successfully gapped in prelim test: 10
Number of HSP's that attempted gapping in prelim test: 2979
Number of HSP's gapped (non-prelim): 13
length of query: 460
length of database: 30,389,216
effective HSP length: 110
effective length of query: 350
effective length of database: 23,708,036
effective search space: 8297812600
effective search space used: 8297812600
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)