ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactII3037 check: MH T KOG1240 Signal transduction mechanisms Protein kinase containing WD40 repeats
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactII3037 1047582 1043347 -1412
(1412 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YBR097w [T] KOG1240 Protein kinase containing WD40 repeats 1053 0.0
Hs14728229 [T] KOG1240 Protein kinase containing WD40 repeats 404 e-112
SPBC119.07 [T] KOG1240 Protein kinase containing WD40 repeats 367 e-101
7299144 [T] KOG1240 Protein kinase containing WD40 repeats 344 5e-94
At4g29380 [T] KOG1240 Protein kinase containing WD40 repeats 333 2e-90
CE06671 [T] KOG1240 Protein kinase containing WD40 repeats 246 1e-64
SPCC18B5.11c [D] KOG0615 Serine/threonine protein kinase Chk2 an... 70 3e-11
Hs4506735 [T] KOG0603 Ribosomal protein S6 kinase 69 5e-11
7302464 [R] KOG0586 Serine/threonine protein kinase 65 8e-10
SPAC1805.01c [T] KOG1152 Signal transduction serine/threonine ki... 65 1e-09
SPAC14C4.03 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase... 64 2e-09
CE17284 [T] KOG0583 Serine/threonine protein kinase 63 3e-09
Hs4505785 [G] KOG0599 Phosphorylase kinase gamma subunit 63 4e-09
Hs7661974 [T] KOG0583 Serine/threonine protein kinase 62 6e-09
Hs4507281 [R] KOG0593 Predicted protein kinase KKIAMRE 62 6e-09
CE11556 [DKL] KOG0659 Cdk activating kinase (CAK)/RNA polymerase... 62 6e-09
YPL209c [D] KOG0580 Serine/threonine protein kinase 61 1e-08
7297578 [T] KOG0661 MAPK related serine/threonine protein kinase 61 1e-08
7300435 [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and r... 61 1e-08
SPAC9G1.02 [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 an... 60 2e-08
YJL095w [T] KOG0198 MEKK and related serine/threonine protein ki... 59 4e-08
CE02602_1 [T] KOG0660 Mitogen-activated protein kinase 59 4e-08
CE12408 [T] KOG0661 MAPK related serine/threonine protein kinase 59 5e-08
Hs4759052 [T] KOG0603 Ribosomal protein S6 kinase 59 7e-08
CE27768 [R] KOG0586 Serine/threonine protein kinase 59 7e-08
CE23838 [R] KOG0586 Serine/threonine protein kinase 59 7e-08
Hs4507277_1 [R] KOG0589 Serine/threonine protein kinase 58 9e-08
Hs6031180 [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and... 58 1e-07
Hs5803088 [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and... 58 1e-07
Hs5453882 [G] KOG0599 Phosphorylase kinase gamma subunit 58 1e-07
7299437 [R] KOG0586 Serine/threonine protein kinase 58 1e-07
Hs4505569 [R] KOG0593 Predicted protein kinase KKIAMRE 57 2e-07
YKL166c [T] KOG0616 cAMP-dependent protein kinase catalytic subu... 57 2e-07
CE27894_1 [R] KOG0589 Serine/threonine protein kinase 57 2e-07
SPBC4C3.11 [T] KOG0592 3-phosphoinositide-dependent protein kina... 56 4e-07
Hs18552621 [R] KOG0597 Serine-threonine protein kinase FUSED 56 4e-07
Hs14728804 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase ... 56 4e-07
7294217 [D] KOG0588 Serine/threonine protein kinase 56 4e-07
7301004 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-... 56 5e-07
7297542 [T] KOG0616 cAMP-dependent protein kinase catalytic subu... 56 5e-07
Hs20545245 [D] KOG0588 Serine/threonine protein kinase 55 6e-07
At4g18700 [T] KOG0583 Serine/threonine protein kinase 55 6e-07
At5g45810 [T] KOG0583 Serine/threonine protein kinase 55 8e-07
At4g14780 [T] KOG0192 Tyrosine kinase specific for activated (GT... 55 8e-07
Hs13899225 [R] KOG0586 Serine/threonine protein kinase 55 1e-06
7295638 [T] KOG0603 Ribosomal protein S6 kinase 55 1e-06
Hs9845489 [R] KOG0586 Serine/threonine protein kinase 54 1e-06
Hs9845487 [R] KOG0586 Serine/threonine protein kinase 54 1e-06
Hs22062450 [R] KOG0586 Serine/threonine protein kinase 54 1e-06
Hs4759050 [T] KOG0603 Ribosomal protein S6 kinase 54 2e-06
At1g30270 [T] KOG0583 Serine/threonine protein kinase 54 2e-06
Hs7657526 [T] KOG0603 Ribosomal protein S6 kinase 54 2e-06
Hs19923464 [T] KOG0577 Serine/threonine protein kinase 54 2e-06
At5g57630 [T] KOG0583 Serine/threonine protein kinase 54 2e-06
At3g29160 [T] KOG0583 Serine/threonine protein kinase 54 2e-06
At3g22750 [T] KOG0192 Tyrosine kinase specific for activated (GT... 54 2e-06
At2g25090 [T] KOG0583 Serine/threonine protein kinase 54 2e-06
Hs8923922 [R] KOG0586 Serine/threonine protein kinase 53 3e-06
Hs5730055 [D] KOG0575 Polo-like serine/threonine protein kinase 53 3e-06
Hs20479818 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase ... 53 3e-06
CE18169 [T] KOG0603 Ribosomal protein S6 kinase 53 3e-06
CE13014 [T] KOG0603 Ribosomal protein S6 kinase 53 3e-06
Hs8922679 [R] KOG0275 Conserved WD40 repeat-containing protein 53 4e-06
CE28482 [S] KOG1408 WD40 repeat protein 53 4e-06
CE20142 [T] KOG0592 3-phosphoinositide-dependent protein kinase ... 53 4e-06
CE06762 [T] KOG0660 Mitogen-activated protein kinase 53 4e-06
Hs19311016_1 [R] KOG0589 Serine/threonine protein kinase 53 4e-06
YDR466w [T] KOG0592 3-phosphoinositide-dependent protein kinase ... 52 5e-06
YCR073c [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and r... 52 5e-06
SPAC31G5.09c [T] KOG0660 Mitogen-activated protein kinase 52 5e-06
Hs7657214 [T] KOG0583 Serine/threonine protein kinase 52 5e-06
Hs20547806 [R] KOG0589 Serine/threonine protein kinase 52 5e-06
7299536 [D] KOG0580 Serine/threonine protein kinase 52 5e-06
7299438 [R] KOG0586 Serine/threonine protein kinase 52 5e-06
YBL016w [T] KOG0660 Mitogen-activated protein kinase 52 7e-06
SPCC320.12c [D] KOG0580 Serine/threonine protein kinase 52 7e-06
SPAC24B11.06c [T] KOG0660 Mitogen-activated protein kinase 52 7e-06
Hs4506089 [T] KOG0660 Mitogen-activated protein kinase 52 7e-06
SPBC32C12.03c [T] KOG0583 Serine/threonine protein kinase 52 9e-06
HsM4505103 [R] KOG0586 Serine/threonine protein kinase 52 9e-06
Hs19923570 [T] KOG0603 Ribosomal protein S6 kinase 52 9e-06
At5g58380 [T] KOG0583 Serine/threonine protein kinase 52 9e-06
>YBR097w [T] KOG1240 Protein kinase containing WD40 repeats
Length = 1454
Score = 1053 bits (2722), Expect = 0.0
Identities = 598/1467 (40%), Positives = 867/1467 (58%), Gaps = 73/1467 (4%)
Query: 1 MGAQLSLLAQTAPSIAISSYVDVLDEVHYQSQLNSSRFLKTCKALDPNGEIVVKVFLKPT 60
MGAQLSL+ Q +PSIAI SY+DVL+EVHY SQLNSSRFLKTCKALDPNGEIV+KVF+KP
Sbjct: 1 MGAQLSLVVQASPSIAIFSYIDVLEEVHYVSQLNSSRFLKTCKALDPNGEIVIKVFIKPK 60
Query: 61 ESYDLKSIHDKIERQSLMLRQLPNVLNYSKILYTDRAGYLIRQHLKTNLYDRLSLRPFLQ 120
+ Y L+ +I QS L QLP+VLNYSK++ T+RAGY+IRQHLK NLYDRLSLRP+LQ
Sbjct: 61 DQYSLRPFLQRIRAQSFKLGQLPHVLNYSKLIETNRAGYMIRQHLKNNLYDRLSLRPYLQ 120
Query: 121 EIELKFMAFQLLQILADIHMRDITHGDIKTENIMVTSSNWLILTDFSEYIKPKYLPEDNP 180
+IELKF+AFQLL L DIH +I HGDIKTENI+VTS NW ILTDF+ +IKP YLPEDNP
Sbjct: 121 DIELKFIAFQLLNTLKDIHNLNIVHGDIKTENILVTSWNWCILTDFAAFIKPVYLPEDNP 180
Query: 181 GEYAFYFDTSQRRTCYLAPERFDTKRYNDETIN--KLEKEMDLFSLGCCLFELFTEGRPL 238
GE+ FYFDTS+RRTCYLAPERF++K Y D N +L KEMD+FSLGC + E+F EGRP+
Sbjct: 181 GEFLFYFDTSKRRTCYLAPERFNSKLYQDGKSNNGRLTKEMDIFSLGCVIAEIFAEGRPI 240
Query: 239 FNLSQLFKYK-NGENEALETIRSEIKDPVLQSLILDMIALNPEDRLSARTLLSKYKVTFF 297
FNLSQLFKYK N + E + E+ L++L+LDMI L+P RLS LL+KY+ FF
Sbjct: 241 FNLSQLFKYKSNSYDVNREFLMEEMNSTDLRNLVLDMIQLDPSKRLSCDELLNKYRGIFF 300
Query: 298 PETFYSFIYEYYRNMV-QPAGLSNGNKTTMSLTLEERKRDLDTTVTKIFKDFSKICITGE 356
P+ FY+FIY+Y+RN+V + T + TLE+ + LD T KI++DFS+IC +
Sbjct: 301 PDYFYTFIYDYFRNLVTMTTSTPISDNTCTNSTLEDNVKLLDETTEKIYRDFSQICHCLD 360
Query: 357 YPLNKSDLIIDGD-----------ELS-FVTDTIMINGVGQIKLQKFSTMSG--ESVQNQ 402
+PL K I D E+S F+ + + LQ+F+ +S +SV+ +
Sbjct: 361 FPLIKDGGEIGSDPPILESYKIEIEISRFLNTNLYFPQNYHLVLQQFTKVSEKIKSVKEE 420
Query: 403 SAXXXXXXXXXXXRNLINPKNKERCLEMILILSQYISDTNKLDRVLPFVMFMVFDENSNV 462
A R++++ K + LE++ + +Q++SD NK+DRV+P+ + D + +V
Sbjct: 421 CALLFISYLSHSIRSIVSTATKLKNLELLAVFAQFVSDENKIDRVVPYFVCCFEDSDQDV 480
Query: 463 KALAIKVTAQLLLITETIYHTNANVFVDYILPRLNK-ICQSPQTDGYVRMVLANTLGHFA 521
+AL++ Q+L + N N+FVDY+LPRL + + + Q Y+R+V AN L A
Sbjct: 481 QALSLLTLIQVLTSVRKLNQLNENIFVDYLLPRLKRLLISNRQNTNYLRIVFANCLSDLA 540
Query: 522 TSAIRFHELPYLLSFQSSKVAEVNQLQ----NVRRKLLRQFEEITTTLLTAPEPHVKEAL 577
RF E + + + ++ KL++ E++T + LT + +VK AL
Sbjct: 541 IIINRFQEFTFAQHCNDNSMDNNTEIMESSTKYSAKLIQSVEDLTVSFLTDNDTYVKMAL 600
Query: 578 LSNILPICHLFGKERTNDIILSHLITYLNDKNXXXXXXXXXXXTGVSVLLGSVALEQYIL 637
L NILP+C FG+ERTNDIILSHLITYLNDK+ +G+S+LLG+V LEQYIL
Sbjct: 601 LQNILPLCKFFGRERTNDIILSHLITYLNDKDPALRVSLIQTISGISILLGTVTLEQYIL 660
Query: 638 PLLTQTLSDSEEAVVISVIQSLISFCKVGLLKSKYFYDIASEIAVLVLHPNFWVREYTML 697
PLL QT++DSEE VVISV+QSL S K GL++ KY+ DI+ + L+LHPN W+R++T++
Sbjct: 661 PLLIQTITDSEELVVISVLQSLKSLFKTGLIRKKYYIDISKTTSPLLLHPNNWIRQFTLM 720
Query: 698 LLIEMASKLSKPELYCMMYPIIKPFFEFDVEMTWESLLISSKKPVSRNVYNLLCSWTLRS 757
++IE+ +KLSK E+YC++YPII+PFFEFDVE ++S++ K+PVSR+VYNLLCSW++R+
Sbjct: 721 IIIEIINKLSKAEVYCILYPIIRPFFEFDVEFNFKSMISCCKQPVSRSVYNLLCSWSVRA 780
Query: 758 SKSLFWKHLPTKNVNSFGNNTVEFISKNFSVNNYGFQTNFKPSKSHVTSIA--------- 808
SKSLFWK + T +V+SFGNN +EFI+KN+S NYGF S S + I
Sbjct: 781 SKSLFWKKIITNHVDSFGNNRIEFITKNYSSKNYGFNKRDTKSSSSLKGIKTSSTVYSHD 840
Query: 809 NIEIPLTTEDKNWIDKIKNVGLSETELWKLAALRPYVFRVSKMLSRKPETQSN--EYDDI 866
N EIPLT ED NWIDK +GL+E ++WK+ ALR YV R +++++ P+ N Y +
Sbjct: 841 NKEIPLTAEDINWIDKFHIIGLTEKDIWKIVALRGYVIRTARVMAANPDFPYNNSNYRPL 900
Query: 867 LTE-----RRVFGLPQTVLFDIEAVDSSKEQNTHVILKH-----ITSKDNISGKMKYTSP 916
+ +P+ + FD+E + S + L++ + S K+
Sbjct: 901 VQNSPPNLNLTNIMPRNIFFDVEFAEESTSEGQDSNLENQQIYKYDESEKDSNKLNINGS 960
Query: 917 HILQRPIDMNGSLILTPKSHPVINSSSENVYIQFEPRT---PPXXXXXXXXXXXXXXXKF 973
L +D+NGSLI KS S+ +NV++Q EP + K
Sbjct: 961 KQLSTVMDINGSLIFKNKSIATTTSNLKNVFVQLEPTSYHMHSPNHGLKDNANVKPERKV 1020
Query: 974 KVTNSYNGHQNSIVEYLRSIDIKPPLKSFREFGESYMESALPFSFTEFNTL--KFISSLS 1031
V+NSY G SI ++L + I PPL+ ++EFG P L K I++L
Sbjct: 1021 VVSNSYEGDVESIEKFLSTFKILPPLRDYKEFGPIQEIVRSP----NMGNLRGKLIATLM 1076
Query: 1032 DHKPAPVTAVAAN-NYKPYIVTGSDDGFLKIWDLSKIEKGSTFKPVVNHELGSSIVDITF 1090
+++P +T+ A + PY++TGSD G +KIW+L +I G + + ++ S++ IT
Sbjct: 1077 ENEPNSITSSAVSPGETPYLITGSDQGVIKIWNLKEIIVGEVYSSSLTYDCSSTVTQITM 1136
Query: 1091 IANYDVFVVSANDGSINLFKINF---KNHITNREIQCIE--NLRHFTFKEAKEYGTSLSY 1145
I N+D F VS+ DG I + K+N ++ + +CI NL++F EY +
Sbjct: 1137 IPNFDAFAVSSKDGQIIVLKVNHYQQESEVKFLNCECIRKINLKNF---GKNEYAVRMRA 1193
Query: 1146 TNDDSKPWIITVTNHGRIVMLDIRDMSVVHQIVIXXXXXXXXXXXXXXDGHWLLCGTTHG 1205
++ K ++ +TN R+++ DIR + + I + L+ GTT G
Sbjct: 1194 FVNEEKSLLVALTNLSRVIIFDIRTLERLQIIENSPRHGAVSSICIDEECCVLILGTTRG 1253
Query: 1206 ALLLWNLTFKILVKSWCFGDESPIRKVILFQKDSRKNEYSAIVTGGSSKCLFTIWNLTRL 1265
+ +W++ F +L++SW FGD +PI V + Q + S IV GGSSK TIWN +
Sbjct: 1254 IIDIWDIRFNVLIRSWSFGDHAPITHVEVCQFYGKN---SVIVVGGSSKTFLTIWNFVKG 1310
Query: 1266 QVEEVVSSSNMDTSIDYLVPKPFKRG-TKLNQTAILKNDYVCEYIYRQGNVYYADGLTSE 1324
+ +S+ S+++ + P ++G +LN I + + + D TS
Sbjct: 1311 HCQYAFINSDEQPSMEHFL--PIEKGLEELNFCGIRSLNALSTISVSNDKILLTDEATSS 1368
Query: 1325 IYRYNIRNRSN---VXXXXXXXXXXXXNATKLTLNCWLTTVGKTWDHNIQDRVTYYHTDL 1381
I +++ S+ V L L + +T H++ D + YH D+
Sbjct: 1369 IVMFSLNELSSSKAVISPSRFSDVFIPTQVTANLTMLLRKMKRTSTHSVDD--SLYHHDI 1426
Query: 1382 INCMTFGCLQSAAALVSADNSGMIHLY 1408
IN ++ + LV+ DNSG+I ++
Sbjct: 1427 INSISTCEVDETPLLVACDNSGLIGIF 1453
>Hs14728229 [T] KOG1240 Protein kinase containing WD40 repeats
Length = 1358
Score = 404 bits (1039), Expect = e-112
Identities = 337/1283 (26%), Positives = 576/1283 (44%), Gaps = 155/1283 (12%)
Query: 8 LAQTAPS--IAISSYVDVLDEVHYQSQLNSSRFLKTCKALDPNGEIVVKVFLKPTESYDL 65
LA APS +++ SY + + Y L S+RF K +A G +VVKVF + L
Sbjct: 5 LAGIAPSQILSVESYFSDIHDFEYDKSLGSTRFFKVARAKHREGLVVVKVFAIQDPTLPL 64
Query: 66 KSIHDKIERQSLMLRQLPNVLNYSKILY--TDRAGYLIRQHLKTNLYDRLSLRPFLQEIE 123
S ++E + L N L + K +++A L RQ+++ NLYDR+S RPFL IE
Sbjct: 65 TSYKQELEELKIRLNSAQNCLPFQKASEKASEKAAMLFRQYVRDNLYDRISTRPFLNNIE 124
Query: 124 LKFMAFQLLQILADIHMRDITHGDIKTENIMVTSSNWLILTDFSEYIKPKYLPEDNPGEY 183
+++AFQ+L + H + HGDIKTEN+MVTS NW++LTDF+ + KP YLPEDNP ++
Sbjct: 125 KRWIAFQILTAVDQAHKSGVRHGDIKTENVMVTSWNWVLLTDFASF-KPTYLPEDNPADF 183
Query: 184 AFYFDTSQRRTCYLAPERF-DTKRY-------------------NDETINKLEKEMDLFS 223
++FDTS+RRTCY+APERF D + N T +L++ MD+FS
Sbjct: 184 NYFFDTSRRRTCYIAPERFVDGGMFATELEYMRDPSTPLVDLNSNQRTRGELKRAMDIFS 243
Query: 224 LGCCLFELFTEGRPLFNLSQLFKYKNGENEALETIRSEIKDPVLQSLILDMIALNPEDRL 283
GC + ELFTEG PLF+LSQL Y+NG E + ++I+D ++ L+ MI P+ RL
Sbjct: 244 AGCVIAELFTEGVPLFDLSQLLAYRNGHFFP-EQVLNKIEDHSIRELVTQMIHREPDKRL 302
Query: 284 SARTLLSKYKVTFFPETFYSFIYEYYRNMVQPAGLSNGNKTTMSLTLEERKRDLDTTVTK 343
A L + + FP E + +QP +T +S D +
Sbjct: 303 EAEDYLKQQRGNAFP--------EIFYTFLQPYMAQFAKETFLSA---------DERILV 345
Query: 344 IFKDFSKICITGEYPLNKSDLIIDGDELSFVTDTIMINGVGQIKLQKFSTMSGESVQNQS 403
I KD I + G +L GE +N
Sbjct: 346 IRKDLGNIIHN-----------LCGHDLP-------------------EKAEGEPKEN-G 374
Query: 404 AXXXXXXXXXXXRNLINPKNKERCLEMILILSQYISDTNKLDRVLPFVMFMVFDENSNVK 463
+ L +K LE+IL L+ +S LDR+ P+++ D V+
Sbjct: 375 LVILVSVITSCLQTLKYCDSKLAALELILHLAPRLSVEILLDRITPYLLHFSNDSVPRVR 434
Query: 464 ALAIKVTAQLLLITETIYHTNANVFVDYILPRLNKICQSPQTDGYVRMVLANTLGHFATS 523
A A++ ++L + + + + N++ +YILP + + Q T VR+ A + A +
Sbjct: 435 AEALRTLTKVLALVKEVPRNDINIYPEYILPGIAHLAQDDAT--IVRLAYAENIALLAET 492
Query: 524 AIRFHELPYLLSFQSSKVAEVNQLQNVR----------RKLLRQFEEITTTLLTAPEPHV 573
A+RF EL L + ++ V + L ++ TLL+ PE V
Sbjct: 493 ALRFLELVQLKNLNMENDPNNEEIDEVTHPNGNYDTELQALHEMVQQKVVTLLSDPENIV 552
Query: 574 KEALLSN-ILPICHLFGKERTNDIILSHLITYLNDKNX-XXXXXXXXXXTGVSVLLGSVA 631
K+ L+ N I +C FG+++ ND++LSH+IT+LNDKN GV+ +G +
Sbjct: 553 KQTLMENGITRLCVFFGRQKANDVLLSHMITFLNDKNDWHLRGAFFDSIVGVAAYVGWQS 612
Query: 632 LEQYILPLLTQTLSDSEEAVVISVIQSLISFCKVGLLKSKYFYDIASEIAVLVLHPNFWV 691
+ PLL Q LSD+EE V++ + +L C++GLL+ + Y+ AS+IA + HPN W+
Sbjct: 613 -SSILKPLLQQGLSDAEEFVIVKALYALTCMCQLGLLQKPHVYEFASDIAPFLCHPNLWI 671
Query: 692 REYTMLLLIEMASKLSKPELYCMMYPIIKPFFEFDVEMTWESLLISS--KKPVSRNVYNL 749
R + + +A ++S ++YC + P + P+ + L++ S K+PVSR++++
Sbjct: 672 RYGAVGFITVVARQISTADVYCKLMPYLDPYITQPIIQIERKLVLLSVLKEPVSRSIFD- 730
Query: 750 LCSWTLRSSKSLFWKHLPTKNVNSFGNNTVEFISKNFSVNNYGFQTNFKPSKSHVTSIAN 809
+ LRS K++ S F+ K S+ +
Sbjct: 731 ---YALRS-----------KDITSL------------------FRHLHMRQKKRNGSLPD 758
Query: 810 IEIPLTTEDKNWIDKIKNVGLSETELWKLAALRPYVFRVSKMLSRKPETQSNEYDDILTE 869
P + K+ + G++E E KL AL+ ++ + +K + + QS+ +D ++
Sbjct: 759 CPPPEDPAIAQLLKKLLSQGMTEEEEDKLLALKDFMMKSNKAKANIVD-QSHLHDS--SQ 815
Query: 870 RRVFGLPQTVLF--DIEAVDSSKEQNTHVILKHITSKDNISGKMK-----YTSPHILQR- 921
+ V L + ++ V + +E + KH+ N++ + K P++ Q
Sbjct: 816 KGVIDLAALGITGRQVDLVKTKQEPDDKRARKHVKQDSNVNEEWKSMFGSLDPPNMPQAL 875
Query: 922 PIDMNGSLILTPKSHPVINSSSENVYIQFEPRTPPXXXX--------XXXXXXXXXXXKF 973
P + +I T K +S+ V + + P +
Sbjct: 876 PKGSDQEVIQTGKPPRSESSAGICVPLSTSSQVPEVTTVQNKKPVIPVLSSTILPSTYQI 935
Query: 974 KVTNSYNGHQNSIVEYLRSIDIKPPLKSFREFGESYMESALPFSFTEFNTLKFISSLSDH 1033
++T Q I + + + K E E ES P L ++ L +H
Sbjct: 936 RITTCKTELQQLIQQKREQCNAERIAKQMMENAE--WESKPPPPGWRPKGL-LVAHLHEH 992
Query: 1034 KPAPVTAVAANNYKPYIVTGSDDGFLKIWDLSKIE-KGSTFKPVVNH-ELGSSIVDITFI 1091
K A V + ++ T S+DG +KIW+ K+E K +T + ++ + +G + +TF
Sbjct: 993 KSA-VNRIRVSDEHSLFATCSNDGTVKIWNSQKMEGKTTTTRSILTYSRIGGRVKTLTFC 1051
Query: 1092 ANYDVFVVSANDGSINLFKINFKNHITNREIQCIENLRHFTFKEAKEYG--TSLSYTNDD 1149
+++++G++ L I + +I +++ + KE G + + N
Sbjct: 1052 QGSHYLAIASDNGAVQLLGIEASKLPKSPKIHPLQS----RILDQKEDGCVVDMHHFNSG 1107
Query: 1150 SKPWIITVTNHGRIVMLDIRDMSVVHQIVIXXXXXXXXXXXXXXDGHWLLCGTTHGALLL 1209
++ + T +G +V D+R S + WL GT+ G +
Sbjct: 1108 AQSVLAYATVNGSLVGWDLRSSSNAWTLKHDLKSGLITSFAVDIHQCWLCIGTSSGTMAC 1167
Query: 1210 WNLTFKILVKSWCFGDESPIRKV 1232
W++ F++ + S C + IR++
Sbjct: 1168 WDMRFQLPISSHCHPSRARIRRL 1190
>SPBC119.07 [T] KOG1240 Protein kinase containing WD40 repeats
Length = 1706
Score = 367 bits (941), Expect = e-101
Identities = 299/1021 (29%), Positives = 477/1021 (46%), Gaps = 110/1021 (10%)
Query: 1 MGAQLSLLAQTAPSIAISSYVDVLDEVHYQSQLNSSRFLKTCKALDPNG-EIVVKVFLKP 59
MG QLS + QT + + + L E H + L S FL+T + D G ++++KVF+
Sbjct: 1 MGIQLSTI-QTPQFHEL--FEEELPEYHNERSLGDSHFLRTFRMQDRKGYDVLIKVFVNK 57
Query: 60 TESYDLKSIHDKI-ERQSLMLRQLPNVLNYSKILYTDRAGYLIRQHLKTNLYDRLSLRPF 118
L SI + + E Q + ++PN + Y K L T RA YL+R ++ NLYDR+S RPF
Sbjct: 58 LPEISLSSIVNLLKEEQENISYRVPNAVPYIKTLVTLRAAYLVRPYVTHNLYDRISTRPF 117
Query: 119 LQEIELKFMAFQLLQILADIHMRDITHGDIKTENIMVTSSNWLILTDFSEYIKPKYLPED 178
L+ E K++ FQLL+ ++D H + HGDIK+ENI++TS NW L+DFS + KP YLPED
Sbjct: 118 LELTEKKWIMFQLLKGISDCHRLGVCHGDIKSENILITSWNWAYLSDFSSF-KPTYLPED 176
Query: 179 NPGEYAFYFDTSQRRTCYLAPERFDTKRYNDETINKLEKEMDLFSLGCCLFELFTEGRPL 238
NP +Y ++FDTS RR C +APERF L MD+FSLGC EL E PL
Sbjct: 177 NPADYGYFFDTSSRRVCNIAPERFVPASQLQPA--PLSPAMDIFSLGCVFAELLLEESPL 234
Query: 239 FNLSQLFKYKNGENEALETIRSEIKDPVLQSLILDMIALNPEDRLSARTLLSKYKVTFFP 298
F LSQLF YK + L+++ +I+D Q++IL M+ +P RLSA L KY+ T FP
Sbjct: 235 FTLSQLFSYKAHGSYDLQSVLEQIEDKSTQNMILSMLDRDPSQRLSADAYLQKYRGTVFP 294
Query: 299 ETFYSFIYEYYRNMVQPAGLSNGNKTTMSLTLEERKRDLDTTVTKIFKDFSKICITGEYP 358
FY +Y+Y +V P+G+ + + + +L + + I++D P
Sbjct: 295 ACFYDTLYDYCIGLVDPSGILSAKQPNDACSL------YGSRIDDIYRDI--------MP 340
Query: 359 LNKSDLIIDGDELSFVTDTIMINGVGQIKLQKFSTMSGESVQNQSAXXXXXXXXXXXRNL 418
N +D+ + + NG+ + F+T+ +N +A +
Sbjct: 341 PNNNDI------SNLMHTPHEYNGIDSYSVPLFTTLDEFYNKNPAAKNWYLRLYNTMQEK 394
Query: 419 INPKNKER------CLEMILILSQYISDTNKL---DRVLPFVMFMVFDEN---SNVKALA 466
++KE+ +I +S +D N L +LP V+ + N S + AL+
Sbjct: 395 KGFEDKEQGSTPAPSPSVIEDISSIETDENHLYGAAVLLPIVLSTIRHVNTRESKINALS 454
Query: 467 --------------------------------IKVTAQLLLITETIYHT------NANVF 488
++++A L+ IT + + NA +F
Sbjct: 455 LVQILSRNICDESKLDTVLPFVMTLLRDQYADVRISA-LITITRLVSNVTSIAPINAFLF 513
Query: 489 VDYILPRLNKICQSPQTDGYVRMVLANTLGHFATSAIRFHELPY------LLSFQSSKVA 542
+Y+ P L + R A+ L A A +F L +LSF S+
Sbjct: 514 QEYLFPDLQHFLF--DMNSRTRATYASCLPILAKQASKFLNLAQSLRNAGILSFPESEYE 571
Query: 543 EVNQ------LQNVRRKLLRQFEEITTTLLTAPEPHVKEALLSNILPICHLFGKERTNDI 596
+N + R L+ E +TLL V+ +LL+ + P+C FGK ++ND+
Sbjct: 572 NINHGKAELLFETGRHDLVVTVERHVSTLLADSSSIVRRSLLNALAPLCVFFGKAKSNDL 631
Query: 597 ILSHLITYLNDKNXXXXXXXXXXXTGVSVLLGSVALEQYILPLLTQTLSDSEEAVVISVI 656
ILSHLITYLND + TG+S+ +G ++++YILPL+ Q L D E AV+ SV+
Sbjct: 632 ILSHLITYLNDTDWMLRCAFFESITGLSIFIGPRSVDEYILPLMLQALVDPEPAVLESVL 691
Query: 657 QSLISFCKVGLLKSKYFYDIASEIAVLVLHPNFWVREYTMLLLIEMASKLSKPELYCMMY 716
S ++ L + DI + LV PN ++R + ++ + C++
Sbjct: 692 GSFSGLIELHLFEKLVVVDILQLVLPLVAVPNAYIRRAALSVIYSAYQSFDDIDRDCIVT 751
Query: 717 PIIKPFFEFDV--EMTWESLLISSKKPVSRNVYNLLCSWTLRSSKSLFWKHLPTKNVNSF 774
P+++P+ ++ + E L VS +V++ L W S S FWK + +S
Sbjct: 752 PLLRPYLMSNLCDINSLEKLDQFILPMVSDSVWSTLTRWYEESENSSFWKCDKDASYSSL 811
Query: 775 --GNNTVEFISKNFS----VNNYGFQTNFKPS-KSHVTSIANIEIPLTTEDKNWIDKIKN 827
N+++ +KN +++ T+ K S HV + + L+ +D+ W D IK
Sbjct: 812 DVSNDSLLGRTKNLQKREIMHHAEVYTHKKISLTGHVIITSTEMLELSEDDQKWADIIKE 871
Query: 828 VGLSETELWKLAALRPYVFRVSKMLSRKPETQSNEYDDILT--ERRVFGLPQTVLFDIEA 885
+G+ LW LA LR YV + L+ + + ++ T + LP+T+ ++ E
Sbjct: 872 MGVDVKHLWVLANLRDYVKKTKINLNGINYKRQSGLRELNTYPNAPLHILPETIFWNPER 931
Query: 886 VDSSKEQNTHVILKHITSKDNISGKMKYTSPHILQRPI-----DMNGSLILTPKSHPVIN 940
SS N L + ++I Y I + PI DM + T K V
Sbjct: 932 PPSSSIAN-ETFLDRNSYAESIQTSRSYNDDLIARDPIAYVGTDMTNAFGTTTKPKDVSQ 990
Query: 941 S 941
S
Sbjct: 991 S 991
Score = 54.3 bits (129), Expect = 1e-06
Identities = 54/215 (25%), Positives = 83/215 (38%), Gaps = 25/215 (11%)
Query: 1049 YIVTGSDDGFLKIWDL-SKIEKGSTFKPVVNHELGS----------SIVDITFIANYDVF 1097
+ VT DG ++ W L + ST + G S+V+ F+ N F
Sbjct: 1229 FFVTLGSDGVVRAWQLVESVRHISTMRCECRLSYGHTRRNGERNRFSVVNGCFLGNTYAF 1288
Query: 1098 VVSANDGSINLFKINFKNH----ITNREIQCIENLRHFTFKEAKEYGTSLSYTNDDSKPW 1153
DGS+ + +++ N I+ I ++ T EA + D
Sbjct: 1289 ASVTQDGSVEVHRLDVNNQRHTLISAGRIPNLDFSDSVTSMEASTF--------HDGSIR 1340
Query: 1154 IITVTNHGRIVMLDIRDMSVVHQIVIXXXXXXXXXXXXXXDGHWLLCGTTHGALLLWNLT 1213
++ VT RIV LD+ M V+ + +W L GTT G LLLW+L
Sbjct: 1341 LVVVTKWSRIVYLDVGMMRVLSSDQLPLQCGSATSVVVSEGCNWALIGTTKGWLLLWDLR 1400
Query: 1214 FKILVKSWCFGDESPIRKVIL--FQKDSRKNEYSA 1246
F L SW ++L +K S NEY++
Sbjct: 1401 FGTLSCSWHMPARIDQMHLLLDVTKKRSNVNEYTS 1435
>7299144 [T] KOG1240 Protein kinase containing WD40 repeats
Length = 1342
Score = 344 bits (883), Expect = 5e-94
Identities = 236/755 (31%), Positives = 372/755 (49%), Gaps = 77/755 (10%)
Query: 26 EVHYQSQLNSSRFLKTCKALDPNGEIVVKVFLKPTESYDLKSIHDKIE--RQSLMLRQLP 83
E+ + S + S+RF K KA G+IVVKVF+K + L+ +++E +++L L
Sbjct: 27 EIAFSSNMGSTRFFKVAKAKTDEGQIVVKVFVKHDPTLPLEDHKERLEGIKKTLSLANAV 86
Query: 84 NVLNYSKILYTDRAGYLIRQHLKTNLYDRLSLRPFLQEIELKFMAFQLLQILADIHMRDI 143
N L + ++ D+A Y++R+++K +LYDR+S RPFL +E K++ FQ+L L H + I
Sbjct: 87 NCLPFQRVELIDKAAYIMREYVKHSLYDRVSTRPFLTVLEKKWITFQILCALNQCHKQKI 146
Query: 144 THGDIKTENIMVTSSNWLILTDFSEYIKPKYLPEDNPGEYAFYFDTSQRRTCYLAPERFD 203
HGDIK ENI++TS NW++L+DF+ + KP YLPEDNP +Y ++FDTS+RRTCY+APERF
Sbjct: 147 CHGDIKLENILITSWNWILLSDFASF-KPTYLPEDNPADYTYFFDTSRRRTCYIAPERFV 205
Query: 204 TKRYNDE----------------------TINKLEKEMDLFSLGCCLFELFTEGRPLFNL 241
+D+ N L MD+FS GC L EL+TEG F L
Sbjct: 206 KTLASDDDGGNGNMSVIHTDSIIRLAPSYAGNTLLPAMDIFSAGCALLELWTEGTAPFEL 265
Query: 242 SQLFKYKNGENEALETIRSEIKDPVLQSLILDMIALNPEDRLSARTLLSKYKVTFFPETF 301
SQL Y+ GE + +E + I++ L++L+ MI ++ +R SA L + + FPE F
Sbjct: 266 SQLLAYRRGERDLVEKHLAGIENERLRNLLASMIDIHSMNRKSAEDYLDQERGQLFPEYF 325
Query: 302 YSFIYEYYRNMVQPAGLSNGNKTTMSLTLEERKRDLDTTVTKIFKDFSKICITGEYPLNK 361
YSF+ Y + +S +K + + KD CI +
Sbjct: 326 YSFLQSYLQMFSSTPIMSPDDK-----------------IQCLHKDIGH-CI--KVLTQA 365
Query: 362 SDLIIDGDELSFVTDTIMINGVGQIKLQKFSTMSGESVQNQSAXXXXXXXXXXXRNLINP 421
DL + +E D + + ++ R L
Sbjct: 366 QDLTPEEEEKEEKKDPTLCARL--------------PPEHDGLILIITVVTSCIRGLKQS 411
Query: 422 KNKERCLEMILILSQYISDTNKLDRVLPFVMFMVFDENSNVKALAIKVTAQLLLITETIY 481
K LE++ LS+Y + LDR+LP+++ + + V+ AI+ L + + I
Sbjct: 412 NTKIAALELLQKLSKYTTSETILDRILPYILHLAQKSPAKVQVQAIETLTACLGMVKDIP 471
Query: 482 HTNANVFVDYILPRLNKICQSPQTDGYVRMVLANTLGHFATSAIRFHELPYLLSFQSSKV 541
++ANVF +YILP + + S + VR+ A + A SA+ F E +
Sbjct: 472 RSDANVFPEYILPSITDLA-SETSAVIVRVAFARNIAALAKSAVYFLEETQRNAPNDMPT 530
Query: 542 ----AEVNQLQNVRRKLLRQFEEITTTLLTAPEPHVKEALL-SNILPICHLFGKERTNDI 596
AE+N L ++ R + +LLT +P VK+ L+ S I +C FGKE+ ND+
Sbjct: 531 PRYEAELNALHDIVR-------QAVLSLLTDSQPVVKQTLMESGICDLCAFFGKEKANDV 583
Query: 597 ILSHLITYLNDKNXXXXXXXXXXXTGVSVLLGSVALEQYILPLLTQTLSDSEEAVVISVI 656
ILSH++T+LND++ GV+ +G A ++PLL Q +D EE V+ I
Sbjct: 584 ILSHIMTFLNDEDKNLRGAFYDNIAGVAGYVGWQA-SDILVPLLQQGFTDREEFVIAKAI 642
Query: 657 QSLISFCKVGLLKSKYFYDIASEIAVLVLHPNFWVREYTMLLLIEMASKLSKPELYCMMY 716
+++ ++G +K +I E A + HPN WVR ++ A LS ++ C +
Sbjct: 643 RAVTILIELGHIKKPAVTEIVQETACYLCHPNLWVRHEICGMIATTARNLSAIDVQCKIM 702
Query: 717 PIIKPFFE---FDVEMTWESLLISSKKPVSRNVYN 748
P I F + VE LL PV R +++
Sbjct: 703 PAIGAFLKAPLIQVEKP-HILLDCVHPPVPRQIFD 736
>At4g29380 [T] KOG1240 Protein kinase containing WD40 repeats
Length = 1494
Score = 333 bits (853), Expect = 2e-90
Identities = 236/798 (29%), Positives = 398/798 (49%), Gaps = 85/798 (10%)
Query: 18 SSYVDVLDEVHYQSQLNSSRFLKTCKALDPNGEIVVKVFLKPTESYDLKSIHDKIERQSL 77
SSY VL EV L RFLK+ + G +VVKV+ K +S DL+ ++ +
Sbjct: 23 SSYNLVLKEV-----LGRGRFLKSIQCKHDEGLVVVKVYFKRGDSIDLREYERRLVKIKD 77
Query: 78 MLRQL--PNVLNYSKILYTDRAGYLIRQHLKTNLYDRLSLRPFLQEIELKFMAFQLLQIL 135
+ L P+V + TD+A YL+RQ+ +NL+DRLS RPFL +E K++AFQLL +
Sbjct: 78 VFLSLEHPHVWPFQFWQETDKAAYLVRQYFYSNLHDRLSTRPFLSLVEKKWLAFQLLLAV 137
Query: 136 ADIHMRDITHGDIKTENIMVTSSNWLILTDFSEYIKPKYLPEDNPGEYAFYFDTSQRRTC 195
H +DI HGDIK EN+++TS NWL L DF+ + KP Y+P D+P +++F+FDT +R C
Sbjct: 138 KQCHEKDICHGDIKCENVLLTSWNWLYLADFASF-KPTYIPYDDPSDFSFFFDTRGQRLC 196
Query: 196 YLAPERF-----DTKRYNDETINKLEKEMDLFSLGCCLFELFTEGRPLFNLSQLFKYKNG 250
YLAPERF +T+ D L+ MD+F++GC + ELF EG+PLF L+QL Y+ G
Sbjct: 197 YLAPERFYEHGGETQVAQDA---PLKPSMDIFAVGCVIAELFLEGQPLFELAQLLAYRRG 253
Query: 251 ENEALETIRSEIKDPVLQSLILDMIALNPEDRLSARTLLSKYKVTFFPETFYSFIYEYY- 309
+++ + + +I DP ++ +IL MI L PE RLSA L Y FP F F++ Y
Sbjct: 254 QHDPSQHL-EKIPDPGIRKMILHMIQLEPEARLSAEDYLQNYVGVVFPNYFSPFLHTLYC 312
Query: 310 -----RNMVQPAGLSNGNKTTMSLTLEERKRD---LDTTVTKIFKDFSKICIT-GEYPLN 360
+ ++ A + + +E + D +D+ VT + S + T + LN
Sbjct: 313 CWNPLPSDMRVATCQGIFQEILKKMMENKSGDEIGVDSPVTSNPMNASTVQETFANHKLN 372
Query: 361 KSDLII-----DGDELSF-VTDTIMING---VGQIKLQKFSTMSG--------------- 396
S +I DE+ + ++D + N + +I + T+
Sbjct: 373 SSKDLIRNTVNSKDEIFYSISDALKKNRHPFLKKITMDDLGTLMSLYDSRSDTYGTPFLP 432
Query: 397 --ESVQNQSAXXXXXXXXXXXRNLINPKNKERCLEMILILSQYISDTNKLDRVLPFVMFM 454
+++ + RN+ P + + ++ S YI D ++L RVLP+V+ +
Sbjct: 433 VEGNMRCEGMVLIASMLCSCIRNIKLPHLRREAILLLRSCSLYIDDDDRLQRVLPYVVAL 492
Query: 455 VFDENSNVKALAIKVTAQLLLITETIYHTNANVFVDYILPRLNKICQSPQTDGYVRMVLA 514
+ D + V+ A++ +L + ++A +F +YI P L+ + + T+ VR+ A
Sbjct: 493 LSDPTAIVRCAAMETLCDILPLVRDFPPSDAKIFPEYIFPMLSMLPE--DTEESVRICYA 550
Query: 515 NTLGHFATSAIRFHELPYLLSFQSSKVAEVNQLQNVR----------------------R 552
+ + A +A F + SFQ S V +N+L + + +
Sbjct: 551 SNIAKLALTAYGF----LIHSFQLSDVGVLNELNSQQISTTPASETPSHLQKANGNAQLQ 606
Query: 553 KLLRQFEEITTTLLTAPE--PHVKEALLSNILPICHLFGKERTNDIILSHLITYLNDKNX 610
+L + E+ L+ P+ P+V+ ALL +I +C FG+ ++ND +L L +LND++
Sbjct: 607 QLRKTIAEVVQELVMGPKQTPNVRRALLQDIGELCFFFGQRQSNDFLLPILPAFLNDRDE 666
Query: 611 XXXXXXXXXXTGVSVLLGSVALEQYILPLLTQTLSDSEEAVVISVIQSLISFCKVGLLKS 670
V +G ++E+Y+LP + Q LSD EAV+++ ++ L + CK L+
Sbjct: 667 QLRSVFFEKIVYVCFFVGQRSVEEYLLPYIDQALSDQTEAVIVNALECLSTLCKSSFLRK 726
Query: 671 KYFYDIASEIAVLVLHPNFWVREYTMLLLIEMASKLSKPELYCMMYPIIKPFF-EFDVEM 729
+ + + L+ +P+ WVR + + + L + Y + P+I+ + +
Sbjct: 727 RALLQMIECVYPLLCYPSQWVRRAVVTFIAASSECLGAVDSYAFIAPVIRSYLSRLPASI 786
Query: 730 TWESLLISS-KKPVSRNV 746
E L+S K PV+R V
Sbjct: 787 ASEEGLLSCLKPPVTREV 804
Score = 82.8 bits (203), Expect = 4e-15
Identities = 58/212 (27%), Positives = 101/212 (47%), Gaps = 5/212 (2%)
Query: 1027 ISSLSDHKPAPVTAVAANNYKPYIVTGSDDGFLKIWDLSKIEKGSTFKPVVNHEL-GSSI 1085
++ L +H+ A V +A ++ + V+ SDD +K+WD K+EK +F+ + + L GS
Sbjct: 1074 VAHLQEHRSA-VNDIATSSDHSFFVSASDDSTVKVWDSRKLEKDISFRSRLTYHLEGSRG 1132
Query: 1086 VDITFIANYDVFVVSANDGSINLFKINFKNHITNREIQCIENLRHFTFKEAKEYG--TSL 1143
+ T + N VV A+DG I++F I+ + ++ + K+ KE + L
Sbjct: 1133 MCTTMLRNSTQVVVGASDGVIHMFSIDHISRGLGNVVEKYSGIVDIKKKDVKEGALVSLL 1192
Query: 1144 SYTNDD-SKPWIITVTNHGRIVMLDIRDMSVVHQIVIXXXXXXXXXXXXXXDGHWLLCGT 1202
+YT D S P ++ T + I + D R + G+W + G+
Sbjct: 1193 NYTADSLSGPMVMYSTQNCGIHLWDTRSDLDAWTLKANPEEGYVSSLVTSPCGNWFVSGS 1252
Query: 1203 THGALLLWNLTFKILVKSWCFGDESPIRKVIL 1234
+ G L LW+L F++ V SW + PI K+ L
Sbjct: 1253 SRGVLTLWDLRFRVPVNSWQYPIICPIEKMCL 1284
>CE06671 [T] KOG1240 Protein kinase containing WD40 repeats
Length = 1354
Score = 246 bits (629), Expect = 1e-64
Identities = 257/1065 (24%), Positives = 446/1065 (41%), Gaps = 137/1065 (12%)
Query: 33 LNSSRFLKTCKALDPNGEIVVKVFLKPTESYDLKSIHDKIERQSLMLRQL----PNVLNY 88
L S+RF+K + G V KVF++ DL S+ D ++ + +R+ PN
Sbjct: 33 LGSTRFMKVARGRTHEGVFVYKVFVRQ----DLASL-DPFPQRIIDIRKALMKSPNCCPI 87
Query: 89 SKILYTDRAGYLIRQHLKTNLYDRLSLRPFLQEIELKFMAFQLLQILADIHMRDITHGDI 148
K+L + ++R K L+DRLS RPF+ E E + F L + L+ + HGD+
Sbjct: 88 KKVLVKQKYAVMVRAFQKHTLFDRLSTRPFVVEAEKMWYIFLLFKALSQCETAGVCHGDL 147
Query: 149 KTENIMVTSSNWLILTDFSEYIKPKYLPEDNPGEYAFYFDTSQRRTCYLAPERFDTKRYN 208
K++N++++S+NWL +TDF+ + KP +L DNP + F+FDTS+R++CY+APERF +
Sbjct: 148 KSQNVLISSTNWLQITDFAPF-KPCFLTHDNPSSFTFFFDTSRRQSCYIAPERFISATEY 206
Query: 209 DETI---------NKLEKEMDLFSLGCCLFELFTEGRPLFNLSQLFKYKN-GENEALETI 258
DE + L +MD+FS GC +FEL + RP F S L +Y++ + +A +
Sbjct: 207 DEKLRDGQDEWLFGSLTPKMDMFSAGCIVFELLCD-RPPFTYSSLCEYRSMNDADAGNML 265
Query: 259 RSEIKD--PVLQSLILDMIALNPEDRLSARTLLSKYKVTFFPETFYSFIYEY---YRNMV 313
I+D + L+ ++ +P R+SA +L+ + FP SF+++Y +R +
Sbjct: 266 LRLIQDVPAPYRPLLRLLLNRDPSFRISANAVLTGAALK-FPHILESFLFKYLDRFRPLY 324
Query: 314 QPAGLSNGNKTTMSLTLEERKRDLDTTVTKIFKDFSKICITGEYPLNKSDLIIDGDELSF 373
+ S+ + S LE + D +TK+ ++
Sbjct: 325 GTSTSSDPSTDDFSQALEFSYLEPDDVITKLKRE-------------------------- 358
Query: 374 VTDTIMINGVGQIKLQKFSTMSGESVQNQSAXXXXXXXXXXXRNLINPKNKERCLEMILI 433
K ++ +S A R L + K + M++
Sbjct: 359 -------------KQLWWARLSENDESKSFAFLFVSLITANLRALRTIQGKTDAIRMLVE 405
Query: 434 LSQYISDTNKLDRVLPFVMFMVFDENSNVKALAIKVTAQLLLITETIYHTNANVFVDYIL 493
LS + +DR+LP+ + + D + V+A A+ A+LL + + + VFVDY+
Sbjct: 406 LSTISDSSVAIDRILPYFVHLWMDPETQVRATAVTAVAELLAPIQPKTYEESLVFVDYLF 465
Query: 494 PRLNKIC-QSPQTDGYVRMVLANTLGHFATSAIRFH----ELPYLLSFQSSKVAEVNQLQ 548
P LN + S + +V +A +LG FA +A RF+ E+ + Q Q
Sbjct: 466 PHLNSMSNDSIDSPQHVLFAIATSLGQFADTAYRFYMAGREIRQATMYDDEVSTAGEQQQ 525
Query: 549 NVRRKLLRQFEEITTTLLTAPEPHVKEALL--SNILPICHLFGKERTNDIILSHLITYLN 606
N L + L + EP VK L+ +++ + H F K +D +L L T+LN
Sbjct: 526 NDDAGALLHGVSAMFSALCSKEPMVKRCLVESKSLILLYHFFIKIGNDDTLLRFLCTFLN 585
Query: 607 DKNXXXXXXXXXXXTGVSVLLGSVALEQYILPLLTQTLSDSEEAVVISVIQSLISFCKVG 666
K V V S + ++PLL L D EE VV+ + + K
Sbjct: 586 AKTEWRLRAAFFDSLPVCVQKRS----EGMVPLLQLGLQDGEEHVVVRALGCIHILIKNE 641
Query: 667 LLKSKYFYDIASEIAVLVLHPNFWVREYTMLLLIEMASKLSKPELYCMMYPIIKPFFEFD 726
L + ++ ++HPN W+R +L+ + + E++ + P++ PF
Sbjct: 642 NLDKMSVKKLLDDVLPFLVHPNDWIRSTVCDILLAIDCQWHNAEVHVKLIPLVSPF---- 697
Query: 727 VEMTWESLLISSKKPVSRNVYNLLCSWTLRSSKSLFWKHLPTKNVNSFGNNTVEFISKNF 786
VE + +L KPV S +P N + ++E +
Sbjct: 698 VEESKRGVLTLKSKPV---------------LMSQLVDPIPRTTFNQIIDQSLENTKQIT 742
Query: 787 SVNNYGFQTNFKPSKSHVTSIANIEIPLTTEDKNWIDKIKNVGLSETELWKLAALRPYVF 846
+ FQT KP ++ I + TE K + + ++ + E K Y F
Sbjct: 743 MLLEIHFQTG-KPFEAGAGWFNTIFPKIKTETKAGVVEHNDL-KAALEARKRLTASVYSF 800
Query: 847 RVSKMLSRKPETQSNEYDDILTERRVFGLPQTVLFDIEAVDSSKEQNTHVILKHIT---S 903
R K+ R ET++ +I R+ + +D S ++ V K T
Sbjct: 801 R--KLFERMAETRNTAGMEIYLTRQ-----------LGTIDLSSIAHSRVRRKEFTYGGD 847
Query: 904 KDNISGKMKY-TSPHILQRPIDMNGSLILTPKSHPVINSSSENVYIQFEPRTPPXXXXXX 962
+ +S K+ T+ +I + +L+L + V+ V P +P
Sbjct: 848 ESAMSSNSKHLTAINIPNHSTERRDTLLLAGE---VVIEEERTVTNTPAPYSPVKNTTFD 904
Query: 963 XXXXXXXXXKFKVTNSYNGHQNSIVEYLRSIDIKP--PLKSFREFGE-SYMESALPFSFT 1019
N H N + ++R+++ +P PL + S SA +
Sbjct: 905 -----------NQVNEMLAHLNEL--HMRNVNCRPKRPLAASASHPVLSASPSAGSLGSS 951
Query: 1020 EFNTLK--FISSLSDHKPAPVTAVAANNYKPYIVTGSDDGFLKIW 1062
N +K I+ L +H +T + AN ++GS DG +K+W
Sbjct: 952 SNNNVKGIIITHLHEHS-GKITKLCANRESDLFLSGSTDGTVKVW 995
>SPCC18B5.11c [D] KOG0615 Serine/threonine protein kinase Chk2 and related
proteins
Length = 460
Score = 69.7 bits (169), Expect = 3e-11
Identities = 65/237 (27%), Positives = 114/237 (47%), Gaps = 21/237 (8%)
Query: 54 KVFLKPTESYDLKSIHDKIERQSLMLRQL--PNVLNYSKILYTDRAGYLIRQHLKT-NLY 110
K+ L +E K + +R+ +L+ L P V+ +I D +++ ++++ +L
Sbjct: 202 KILLTSSE----KRATEMFQREIDILKSLHHPGVVQCHEIFENDDELFIVMEYVEGGDLM 257
Query: 111 DRLSLRPFLQEIELKFMAFQLLQILADIHMRDITHGDIKTENIMVTSSNWLILTDFSEYI 170
D L + E + K + QLL+ L +H + +TH DIK ENI++T+ L ++DF
Sbjct: 258 DFLIANGSIDEQDCKPLLKQLLETLLHLHKQGVTHRDIKPENILITNDFHLKISDFG--- 314
Query: 171 KPKYLPEDNPGEYAFYFDTSQRRTCYLAPERFDTKRYNDETINKLEKEMDLFSLGCCLFE 230
L + G F +T YLAPE +K N + + ++D++SLGC L+
Sbjct: 315 ----LAKVIHGTGTF-LETFCGTMGYLAPEVLKSKNVNLD--GGYDDKVDIWSLGCVLYV 367
Query: 231 LFTEGRPLFNLSQ---LFKYKNGENEALETIRSEIKDPVLQSLILDMIALNPEDRLS 284
+ T P + SQ + G + +EI + + LI M+ +NPE R+S
Sbjct: 368 MLTASIPFASSSQAKCIELISKGAYPIEPLLENEISEEGI-DLINRMLEINPEKRIS 423
>Hs4506735 [T] KOG0603 Ribosomal protein S6 kinase
Length = 772
Score = 68.9 bits (167), Expect = 5e-11
Identities = 59/228 (25%), Positives = 102/228 (43%), Gaps = 32/228 (14%)
Query: 69 HDKIERQSL-MLRQLPNVLNYSKILYTDRAGYLIRQHLKTN-LYDRLSLRPFLQEIELKF 126
H + ER L ++RQ P ++ TD +LI ++ ++ L R + +E E++
Sbjct: 81 HTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRV 140
Query: 127 MAFQLLQILADIHMRDITHGDIKTENIMVTSSNWLILTDFSEYIKPKYLPEDNPGEYAFY 186
+++ L +H I + D+K EN+++ S ++LTDF + ++L E+ ++F
Sbjct: 141 YGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFG--LSKEFLTEEKERTFSFC 198
Query: 187 FDTSQRRTCYLAPERFDTKRYNDETINKLEKEMDLFSLGCCLFELFTEGRPLFNLSQLFK 246
Y+APE +K + K +D +SLG LFEL T P F
Sbjct: 199 GTIE-----YMAPEIIRSKTGHG-------KAVDWWSLGILLFELLTGASP-------FT 239
Query: 247 YKNGENEALETIRSEIK---------DPVLQSLILDMIALNPEDRLSA 285
+ N E R +K PV Q L+ ++ +P+ RL A
Sbjct: 240 LEGERNTQAEVSRRILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGA 287
>7302464 [R] KOG0586 Serine/threonine protein kinase
Length = 739
Score = 65.1 bits (157), Expect = 8e-10
Identities = 64/259 (24%), Positives = 116/259 (44%), Gaps = 34/259 (13%)
Query: 39 LKTCKALDPNGEIVVKVFLKPTESYDLKSIHDKIERQSLMLRQL--PNVLNYSKILYTDR 96
+K K L E+ +K+ K + K+ R+ +++ L PN++ +++ T++
Sbjct: 165 VKLAKHLPTGKEVAIKIIDKTQLN---PGSLQKLFREVRIMKMLDHPNIVKLFQVIETEK 221
Query: 97 AGYLIRQHLKTN-LYDRLSLRPFLQEIELKFMAFQLLQILADIHMRDITHGDIKTENIMV 155
YLI ++ ++D L L ++E E + Q++ + H + I H D+K EN+++
Sbjct: 222 TLYLIMEYASGGEVFDYLVLHGRMKEKEARVKFRQIVSAVQYCHQKRIIHRDLKAENLLL 281
Query: 156 TSSNWLILTDFSEYIKPKYLPEDNPGEYAFYFDTSQRRTCYLAPERFDTKRYNDETINKL 215
S + + DF + E PG DT Y APE F K+Y+
Sbjct: 282 DSELNIKIADFG------FSNEFTPGS---KLDTFCGSPPYAAPELFQGKKYDG------ 326
Query: 216 EKEMDLFSLGCCLFELFTEGRPLFNLSQLFKYKNGENEALETIRSEIKDPVLQS-----L 270
E+D++SLG L+ L + P F+ S L + + +R + + P S L
Sbjct: 327 -PEVDVWSLGVILYTLVSGSLP-FDGSTLRELRE------RVLRGKYRIPFYMSTDCENL 378
Query: 271 ILDMIALNPEDRLSARTLL 289
+ + LNP R S T++
Sbjct: 379 LRKFLVLNPAKRASLETIM 397
>SPAC1805.01c [T] KOG1152 Signal transduction serine/threonine kinase with
PAS/PAC sensor domain
Length = 713
Score = 64.7 bits (156), Expect = 1e-09
Identities = 45/161 (27%), Positives = 74/161 (45%), Gaps = 19/161 (11%)
Query: 83 PNVLNYSKILYTDRAGYLIRQHLKT--NLYDRLSLRPFLQEIELKFMAFQLLQILADIHM 140
PN++ + YL+ + K +L+D + L+P + E E K + FQ+ +A +H
Sbjct: 570 PNIVKMITFFEDNENYYLLTEPQKPGIDLFDYIELKPSISEKESKAIFFQIALAVAHLHS 629
Query: 141 RDITHGDIKTENIMVTSSNWLILTDFSEYIKPKYLPEDNPGEYAFYFDTSQRRTCYLAPE 200
DI H DIK EN+++ + L DF K P FDT + + APE
Sbjct: 630 FDIIHRDIKDENVILEGNGCARLIDFGSSSLTKNGP----------FDTFRGTVGFAAPE 679
Query: 201 RFDTKRYNDETINKLEKEMDLFSLGCCLFELFTEGRPLFNL 241
++Y L KE D+++LG L+ + P +N+
Sbjct: 680 LLRGEKY-------LGKEQDIWALGILLYTIVYRENPYYNI 713
>SPAC14C4.03 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 445
Score = 63.9 bits (154), Expect = 2e-09
Identities = 73/275 (26%), Positives = 121/275 (43%), Gaps = 34/275 (12%)
Query: 30 QSQLNSSRFLKTCKALDPN--GEIVVKVFLKPTESYDLKSIHDKIERQSLMLRQLPNVLN 87
Q L F + A+D N G+ K+ K + K + E L PN++
Sbjct: 163 QRLLGIGGFSRIYMAMDNNTGGQYACKIIDK--KKISTKRFFEDHEMTILRKLDHPNIIK 220
Query: 88 YSKILYTDRAGYLIRQHLKT--NLYDRLSLRPFLQEIELKFMAFQLLQILADIHMRDITH 145
+ + Y + I + + T +L+ L+ + E+ F+ FQ+LQ L +H ++I H
Sbjct: 221 VN-MEYNSETQFFIFEEMVTGGDLFSYLTKLGTVPEVTTLFIMFQILQGLKYLHEQNIIH 279
Query: 146 GDIKTENIMVTSSN----WLILTDFSE---YIKPKYLPEDNPGEYAFYFDTSQRRTCYLA 198
D+K ENI++ SS+ +ILTDF K K L + + T + Y A
Sbjct: 280 RDLKLENILIASSSDTIFRIILTDFGVARCMQKGKRL--------STFVGTPE----YTA 327
Query: 199 PERFDTK---RYNDETINKLEKEMDLFSLGCCLFELFTEGRPLFNLSQLFKYKNGENEAL 255
PE K + E + KE+DL+SLG +F L + P F K + +
Sbjct: 328 PEIQRLKGRSQVEKENSSGYGKEVDLWSLGVIMFLLLSGNSPSFADGVKEKQVDFRDPVW 387
Query: 256 ETIRSEIKDPVLQSLILDMIALNPEDRLSARTLLS 290
+++ + KD LI +++ NP DR + + LS
Sbjct: 388 KSVSRQAKD-----LISNLLKTNPPDRFTVKQCLS 417
>CE17284 [T] KOG0583 Serine/threonine protein kinase
Length = 726
Score = 63.2 bits (152), Expect = 3e-09
Identities = 54/243 (22%), Positives = 103/243 (42%), Gaps = 17/243 (6%)
Query: 48 NGEIVVKVFLKPTESYDLKSIHDKIERQSLMLRQLPNVLNYSKILYTDRAGYLIRQHLKT 107
N ++ +K+ K +DL + +++ + Q N+ + T+ +++ ++
Sbjct: 34 NQKVAIKIIDKKQLGHDLPRVQTEMDALRNLSHQ--NICRLYHYIETEDKFFIVMEYCSG 91
Query: 108 N-LYDRLSLRPFLQEIELKFMAFQLLQILADIHMRDITHGDIKTENIMVTSSNWLILTDF 166
++D + + L+E E + QL+ +A +H + H D+K EN+++T L L DF
Sbjct: 92 GEMFDYIVRKERLEESEARHFFRQLVSAIAFVHSQGYAHRDLKPENLLLTEDLHLKLIDF 151
Query: 167 SEYIKPKYLPEDNPGEYAFYFDTSQRRTCYLAPERFDTKRYNDETINKLEKEMDLFSLGC 226
K + D DT Y APE +Y E D++S+G
Sbjct: 152 GLCAKTEKGRIDKHN-----LDTCCGSPAYAAPELIQGLQYKG-------NEADVWSMGI 199
Query: 227 CLFELFTEGRPLFNLSQLFKYKNGENEALETIRSEIKDPVLQSLILDMIALNPEDRLSAR 286
L+ L P + + YK ++ E P+ + L+ M+ + PE R+S +
Sbjct: 200 LLYTLLVGALPFEDDNMQIMYKKIQSGCF--YEPEFLSPLSKQLLRAMLQVVPERRISVK 257
Query: 287 TLL 289
LL
Sbjct: 258 KLL 260
>Hs4505785 [G] KOG0599 Phosphorylase kinase gamma subunit
Length = 406
Score = 62.8 bits (151), Expect = 4e-09
Identities = 66/268 (24%), Positives = 119/268 (43%), Gaps = 30/268 (11%)
Query: 36 SRFLKTCKALDPNGEIVVKVFLKPTESYD---LKSIHDKIERQSLMLRQL---PNVLNYS 89
S ++ C E VK+ E L+ + + R++ +LRQ+ P+++
Sbjct: 35 SSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHILRQVAGHPHIITLI 94
Query: 90 KILYTDRAGYLIRQHL-KTNLYDRLSLRPFLQEIELKFMAFQLLQILADIHMRDITHGDI 148
+ +L+ + K L+D L+ + L E E + + LL+ ++ +H +I H D+
Sbjct: 95 DSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLEAVSFLHANNIVHRDL 154
Query: 149 KTENIMVTSSNWLILTDFSEYIKPKYLPEDNPGEYAFYFDTSQRRTC----YLAPERFDT 204
K ENI++ + + L+DF + PGE R C YLAPE
Sbjct: 155 KPENILLDDNMQIRLSDFG------FSCHLEPGE-------KLRELCGTPGYLAPEIL-- 199
Query: 205 KRYNDETINKLEKEMDLFSLGCCLFELFTEGRPLFNLSQLFKYK---NGENEALETIRSE 261
K DET KE+DL++ G LF L P ++ Q+ + G+ + + +
Sbjct: 200 KCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQ-FSSPEWD 258
Query: 262 IKDPVLQSLILDMIALNPEDRLSARTLL 289
+ ++ LI ++ ++PE RL+A L
Sbjct: 259 DRSSTVKDLISRLLQVDPEARLTAEQAL 286
>Hs7661974 [T] KOG0583 Serine/threonine protein kinase
Length = 651
Score = 62.0 bits (149), Expect = 6e-09
Identities = 66/279 (23%), Positives = 118/279 (41%), Gaps = 25/279 (8%)
Query: 17 ISSYVDVLDEVHYQSQLNSSRFLKT---CKALDPNGEIV-VKVFLKPTESYDLKSIHDKI 72
+ Y ++L + + F K C L GE+V +K+ K T DL I +I
Sbjct: 1 MKDYDELLKYYELHETIGTGGFAKVKLACHIL--TGEMVAIKIMDKNTLGSDLPRIKTEI 58
Query: 73 ERQSLMLRQLPNVLNYSKILYTDRAGYLIRQHLKTN-LYDRLSLRPFLQEIELKFMAFQL 131
E + Q ++ +L T +++ ++ L+D + + L E E + + Q+
Sbjct: 59 EALKNLRHQ--HICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQI 116
Query: 132 LQILADIHMRDITHGDIKTENIMVTSSNWLILTDFSEYIKPKYLPEDNPGEYAFYFDTSQ 191
+ +A +H + H D+K EN++ + L L DF KPK G ++ T
Sbjct: 117 VSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPK-------GNKDYHLQTCC 169
Query: 192 RRTCYLAPERFDTKRYNDETINKLEKEMDLFSLGCCLFELFTEGRPLFNLSQLFKYKNGE 251
Y APE K Y L E D++S+G L+ L P + + + YK
Sbjct: 170 GSLAYAAPELIQGKSY-------LGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIM 222
Query: 252 NEALETIRSEIKDPVLQSLILDMIALNPEDRLSARTLLS 290
+ + +L L+ M+ ++P+ R+S + LL+
Sbjct: 223 RGKYDVPKWLSPSSIL--LLQQMLQVDPKKRISMKNLLN 259
>Hs4507281 [R] KOG0593 Predicted protein kinase KKIAMRE
Length = 1030
Score = 62.0 bits (149), Expect = 6e-09
Identities = 57/211 (27%), Positives = 100/211 (47%), Gaps = 26/211 (12%)
Query: 42 CKALDPNGEIVVKVFLKPTESYDLKSIHDKIERQSLMLRQLP--NVLNYSKILYTDRAGY 99
C+ + + + +K F E+ ++K + R+ MLR L N++ + Y
Sbjct: 30 CRHKETHEIVAIKKFKDSEENEEVK---ETTLRELKMLRTLKQENIVELKEAFRRRGKLY 86
Query: 100 LIRQHLKTNLYDRLSLRPF-LQEIELKFMAFQLLQILADIHMRDITHGDIKTENIMVTSS 158
L+ ++++ N+ + L P + ++K +QL++ + H DI H DIK EN++++ +
Sbjct: 87 LVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIVHRDIKPENLLISHN 146
Query: 159 NWLILTDFSEYIKPKYLPEDNPGEYAFYFDTSQRRTCYLAPERFDTKRYNDETINKLEKE 218
+ L L DF + L E N Y Y T Y +PE Y K
Sbjct: 147 DVLKLCDFG---FARNLSEGNNANYTEYVAT----RWYRSPELLLGAPYG--------KS 191
Query: 219 MDLFSLGCCLFELFTEGRPLF----NLSQLF 245
+D++S+GC L EL ++G+PLF + QLF
Sbjct: 192 VDMWSVGCILGEL-SDGQPLFPGESEIDQLF 221
>CE11556 [DKL] KOG0659 Cdk activating kinase (CAK)/RNA polymerase II
transcription initiation/nucleotide excision repair
factor TFIIH/TFIIK kinase subunit CDK7
Length = 305
Score = 62.0 bits (149), Expect = 6e-09
Identities = 41/121 (33%), Positives = 67/121 (54%), Gaps = 16/121 (13%)
Query: 120 QEIELKFMAFQLLQILADIHMRDITHGDIKTENIMVTSSNWLILTDFSEYIKPKYLPEDN 179
+E+ + Q+L +A +H ++I H DIK ENI+VTS N + + DF + Y+P+D
Sbjct: 82 EEVPYTWYYTQILSGIAYLHSKEIMHRDIKPENILVTSRNVVKIADFGQAC--FYMPKDP 139
Query: 180 PGEYAFYFDTSQRRTCYLAPE-RFDTKRYNDETINKLEKEMDLFSLGCCLFELFTEGRPL 238
EY D + Y APE F +K+Y + ++D++++GC L EL G+P+
Sbjct: 140 NQEY----DVNVATRWYRAPELLFGSKKY--------KPDVDIWAIGCILAEL-VRGKPI 186
Query: 239 F 239
F
Sbjct: 187 F 187
>YPL209c [D] KOG0580 Serine/threonine protein kinase
Length = 367
Score = 61.2 bits (147), Expect = 1e-08
Identities = 71/266 (26%), Positives = 113/266 (41%), Gaps = 28/266 (10%)
Query: 24 LDEVHYQSQLNSSRFLKT-CKALDPNGEIVVKVFLKPTE--SYDL-KSIHDKIERQSLML 79
LD+ +L +F K C G I ++ E Y+L K ++E Q+ +
Sbjct: 101 LDDFELGKKLGKGKFGKVYCVRHRSTGYICALKVMEKEEIIKYNLQKQFRREVEIQTSLN 160
Query: 80 RQLPNVLNYSKILYTDRAGYLIRQHLKTN-LYDRLSLRPFLQEIELKFMAFQLLQILADI 138
PN+ + ++ YL+ ++L +Y L L +I +Q+ L +
Sbjct: 161 H--PNLTKSYGYFHDEKRVYLLMEYLVNGEMYKLLRLHGPFNDILASDYIYQIANALDYM 218
Query: 139 HMRDITHGDIKTENIMVTSSNWLILTDFS-EYIKPKYLPEDNPGEYAFYFDTSQRRTCYL 197
H ++I H DIK ENI++ +N + LTDF I P PE+ D YL
Sbjct: 219 HKKNIIHRDIKPENILIGFNNVIKLTDFGWSIINP---PENRRKTVCGTID-------YL 268
Query: 198 APERFDTKRYNDETINKLEKEMDLFSLGCCLFELFTEGRPLFNLSQLFKYKNGENEALET 257
+PE +++ Y D TI D ++LG FEL T P + YK AL+
Sbjct: 269 SPEMVESREY-DHTI-------DAWALGVLAFELLTGAPPFEEEMKDTTYK--RIAALDI 318
Query: 258 IRSEIKDPVLQSLILDMIALNPEDRL 283
Q LIL ++ +P+DR+
Sbjct: 319 KMPSNISQDAQDLILKLLKYDPKDRM 344
>7297578 [T] KOG0661 MAPK related serine/threonine protein kinase
Length = 822
Score = 61.2 bits (147), Expect = 1e-08
Identities = 53/179 (29%), Positives = 84/179 (46%), Gaps = 22/179 (12%)
Query: 73 ERQSLMLRQLPNVLNYSKILYTDRAGYLIRQHLKTNLYDRLSLRP-FLQEIELKFMAFQL 131
E +SL PN++ +++ + Y + +++K NLY + R L E ELK + FQ+
Sbjct: 50 EVKSLKKLSHPNIVKLKEVIRENDTLYFVFEYMKENLYQMIKDRDTHLPEPELKSILFQV 109
Query: 132 LQILADIHMRDITHGDIKTENIMVTSSNWLILTDFSEYIKPKYLPEDNPGEYAFYFDTSQ 191
L LA +H H D+K EN++ + + + + DF + + P + Y T
Sbjct: 110 LTGLAFMHRHGFFHRDLKPENLLCSGPDLIKIADFGLAREIRSRP-----PFTDYVST-- 162
Query: 192 RRTCYLAPERFDTKRYNDETINKLEKEMDLFSLGCCLFELFTEGRPLF----NLSQLFK 246
Y APE TI DL+++GC + EL+T RPLF + QLFK
Sbjct: 163 --RWYRAPEVLLHSTNYGSTI-------DLWAMGCIMAELYT-FRPLFPGSSEVDQLFK 211
>7300435 [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and related
serine/threonine protein kinases
Length = 1612
Score = 60.8 bits (146), Expect = 1e-08
Identities = 80/273 (29%), Positives = 127/273 (46%), Gaps = 29/273 (10%)
Query: 28 HYQSQLNSSRFLKTCKALDPN-GEIVV--KVFLKPTESYDLKSIHDKIERQSLMLRQLPN 84
H ++ RF K A++ N GE++ ++ ++P E+ LK++ ++++ + + N
Sbjct: 1324 HRGIKIGQGRFGKVYTAVNNNTGELMAMKEIAIQPGETRALKNVAEELKILEGIKHK--N 1381
Query: 85 VLNYSKILYTDRAGYLIRQHL--KTNLYDRLSLRPFLQEIELKFMAFQLLQILADIHMRD 142
++ Y I R LI L + L + L L E + QLL ++++H
Sbjct: 1382 LVRYYGI-EVHREELLIFMELCSEGTLESLVELTGNLPEALTRRFTAQLLSGVSELHKHG 1440
Query: 143 ITHGDIKTENI-MVTSSNWLILTDFSEYIKPKYLPEDNPGEYAFYFDTSQRRTCYLAPER 201
I H DIKT NI +V SN L L DF +K + PGE Y T Y+APE
Sbjct: 1441 IVHRDIKTANIFLVDGSNSLKLGDFGSAVKIQ-AHTTVPGELQGYVGTQ----AYMAPEV 1495
Query: 202 FDTKRYNDETINKLEKEMDLFSLGCCLFELFTEGRPL----FNLSQLFKYKNGEN-EALE 256
F TK +D + D++S+GC + E+ + RP N +FK GE +A E
Sbjct: 1496 F-TKTNSDGH----GRAADIWSVGCVVVEMASGKRPWAQFDSNFQIMFKVGMGEKPQAPE 1550
Query: 257 TIRSEIKDPVLQSLILDMIALNPEDRLSARTLL 289
++ E D + L D P+ RL+A LL
Sbjct: 1551 SLSQEGHDFIDHCLQHD-----PKRRLTAVELL 1578
>SPAC9G1.02 [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and related
serine/threonine protein kinases
Length = 1401
Score = 60.5 bits (145), Expect = 2e-08
Identities = 70/293 (23%), Positives = 117/293 (39%), Gaps = 23/293 (7%)
Query: 49 GEIVVKVFLKPTESYDLKSIHDKIERQSLMLRQL--PNVLNYSKILYTDRAGYLIRQHLK 106
G+++ +K +S +S D+I + +L +L PNV+ Y + Y+ + +
Sbjct: 1060 GDLLAVKEIKLQDSRTFRSTVDQIHNEMTVLERLNHPNVVTYYGVEVHREKVYIFMEFCQ 1119
Query: 107 T-NLYDRLSLRPFLQEIELKFMAFQLLQILADIHMRDITHGDIKTENIMVTSSNWLILTD 165
+L D L+ E LK QLL+ LA IH + I H DIK NI++ + +D
Sbjct: 1120 GGSLADLLAHGRIEDENVLKVYVVQLLEGLAYIHSQHILHRDIKPANILLDHRGMIKYSD 1179
Query: 166 FSE--YIKPKYLPEDNPGEYAFYFDTSQRRTCYLAPERFDTKRYNDETINKLEKEMDLFS 223
F Y+ P PE + Y+APE + D MD++S
Sbjct: 1180 FGSALYVSPPTDPEVRYEDIQPELQHLAGTPMYMAPEIILGTKKGD------FGAMDIWS 1233
Query: 224 LGCCLFELFTEGRPLFNLSQ--LFKYKNGENEALETIRSEIKDPVLQSLILDMIALNPED 281
LGC + E+ T P + Y ++E + + I +PE
Sbjct: 1234 LGCVILEMMTGSTPWSEMDNEWAIMYHVAAMHTPSIPQNEKISSLARDFIEQCFERDPEQ 1293
Query: 282 RLSARTLLSKYKVTFFPETFYSFIYEYYRNMVQPAGLSNGNKTTMSLTLEERK 334
R A LL+ +T F + + ++ + KT++S T+ E K
Sbjct: 1294 RPRAVDLLTHPWITDFRK----------KTIITMPPATITKKTSLSHTITEEK 1336
>YJL095w [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 1478
Score = 59.3 bits (142), Expect = 4e-08
Identities = 47/172 (27%), Positives = 85/172 (49%), Gaps = 20/172 (11%)
Query: 124 LKFMAFQLLQILADIHMRDITHGDIKTENIMVTSSNWLILTDFSEYIKPKYLPEDNPGEY 183
+K + Q+L+ LA +H + I H D+K +N+++ ++DF K K + ++
Sbjct: 1280 IKHLTTQVLKGLAYLHSKGILHRDMKADNLLLDQDGICKISDFGISRKSKDIYSNS---- 1335
Query: 184 AFYFDTSQRRTCY-LAPERFDTKRYNDETINKLEKEMDLFSLGCCLFELFTEGRPLFNLS 242
D + R T + +APE DTK+ ++D++SLGC + E+F RP NL
Sbjct: 1336 ----DMTMRGTVFWMAPEMVDTKQ-------GYSAKVDIWSLGCIVLEMFAGKRPWSNLE 1384
Query: 243 QL-FKYKNGENEALETIRSEIKDPVLQ---SLILDMIALNPEDRLSARTLLS 290
+ +K G++++ I + + Q + + +NPE R +A LLS
Sbjct: 1385 VVAAMFKIGKSKSAPPIPEDTLPLISQIGRNFLDACFEINPEKRPTANELLS 1436
>CE02602_1 [T] KOG0660 Mitogen-activated protein kinase
Length = 342
Score = 59.3 bits (142), Expect = 4e-08
Identities = 75/317 (23%), Positives = 136/317 (42%), Gaps = 51/317 (16%)
Query: 8 LAQTAPSIAISSYVDVLDEVHY--QSQLNSSRFLKTCKALDP--NGEIVVKVFLKPTESY 63
L + + S + S+ + L+ Y Q L + F C+A+D N ++ +K K T +
Sbjct: 23 LEEQSGSKSCSNDLFCLEATQYLAQENLGAGAFGVVCRAIDSKLNKQVAIK---KITRVF 79
Query: 64 DLKSIHDKIERQSLMLRQLP--NVLNYSKILYTDRAG----YLIRQHLKTNLYDRLSLRP 117
+S R+ + R+L N++N + +L + Y++ ++T+L L
Sbjct: 80 KNQSTAKCALREIRITRELSHENIINSTDVLMRESGSGQDIYIVMDLMETDLLSVLKSNQ 139
Query: 118 FLQEIELKFMAFQLLQILADIHMRDITHGDIKTENIMVTSSNWLILTDFS---EYIKPKY 174
L E ++ +Q+L+ L +H I H D+K N+++ L + DF K
Sbjct: 140 TLNEKHFQYFFYQILKGLKYLHSAGIIHRDLKPANLLLNEDCSLKIADFGMSRSGPSTKT 199
Query: 175 LPEDNP-----GEYAFYFDTSQRRTCYLAPERFDTKRYNDETINKLEKEMDLFSLGCCLF 229
P +P G+ + Y T Y APE ++ + + ++D++S GC L
Sbjct: 200 TPNTSPNAHISGDLSQYVST----LWYRAPEIL-------LSMGEYDTQVDIWSAGCILA 248
Query: 230 ELFTEGRPLF-------NLSQLFKYKNGENEALETIRSEIKDPVLQSLI--------LDM 274
E+ RP+F + L +Y +E + IR IK P ++ I L
Sbjct: 249 EMLLL-RPIFTGTDSYSQIQLLIEYLGTPDE--QVIR-RIKSPSIRDYISSFGPKTPLPF 304
Query: 275 IALNPEDRLSARTLLSK 291
A+ P + AR ++SK
Sbjct: 305 TAMFPNASIEARNIVSK 321
>CE12408 [T] KOG0661 MAPK related serine/threonine protein kinase
Length = 527
Score = 58.9 bits (141), Expect = 5e-08
Identities = 81/362 (22%), Positives = 147/362 (40%), Gaps = 56/362 (15%)
Query: 43 KALDPNGEIVVKVFLKPTESYDLKSIHDKIERQSLMLRQLPNVLNYSKILYTDRAGYLIR 102
K +D + +K K + Y + E +SL PN++ +++ + Y +
Sbjct: 63 KKIDTGDRVAIKRMKK--KFYSWEEAMSLREVKSLKKLNHPNIIKLREVIRENDILYFVF 120
Query: 103 QHLKTNLYDRLSLRP-FLQEIELKFMAFQLLQILADIHMRDITHGDIKTENIMVTSSNWL 161
+ ++ NLY+ + R + E ++ + +Q+LQ LA +H H D+K ENIM + +
Sbjct: 121 EFMQENLYELMKDRDRYFPESVIRNIIYQVLQGLAFMHKNGFFHRDMKPENIMCNGTELV 180
Query: 162 ILTDFSEYIKPKYLPEDNPGEYAFYFDTSQRRTCYLAPE-RFDTKRYNDETINKLEKEMD 220
+ DF + + P Y Y T Y APE + YN +D
Sbjct: 181 KIADFGLAREIRSKP-----PYTDYVST----RWYRAPEILLRSTSYN--------SPID 223
Query: 221 LFSLGCCLFELFTEGRPLF----NLSQLFK------------------YKNGENEALETI 258
+++LGC + EL+ RPLF + QLFK + N + +
Sbjct: 224 MWALGCIMAELYIL-RPLFPGTSEMDQLFKIISILGTPNKDEWPEGYQLASAMNFRFQQV 282
Query: 259 RSEIKDPVLQS-------LILDMIALNPEDRLSARTLLSKYKVTFFPETFYS-FIYEYYR 310
+ + V+ + L++DM+ NPE R +A L +YK E + + +
Sbjct: 283 VATPMEQVVNTISKEGMKLMMDMMLWNPEKRPNANQSL-RYKYFQVAEKLGAPVVSQPAP 341
Query: 311 NMVQPAGLSNGNKTTMSLTLEERKRDLDTTVTKIFKDFSKIC---ITGEYPLNKSDLIID 367
++ ++ T ++T + K+D + + +K+ I PLNK L
Sbjct: 342 GSIRKTSAASVKSDTKAMTAKAAKKDYIGSENVSPQQPAKVIDRHINRNLPLNKETLFEK 401
Query: 368 GD 369
D
Sbjct: 402 SD 403
>Hs4759052 [T] KOG0603 Ribosomal protein S6 kinase
Length = 809
Score = 58.5 bits (140), Expect = 7e-08
Identities = 53/188 (28%), Positives = 90/188 (47%), Gaps = 16/188 (8%)
Query: 53 VKVFLKPTESYDLKSI-HDKIERQSLM-LRQLPNVLNYSKILYTDRAGYLIRQHLKTN-L 109
+KV K T K+ H + ERQ L +RQ P ++ T+ +LI ++ L
Sbjct: 80 MKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGEL 139
Query: 110 YDRLSLRPFLQEIELKFMAFQLLQILADIHMRDITHGDIKTENIMVTSSNWLILTDFSEY 169
+ LS R E E++ +++ L +H I + DIK ENI++ S+ ++LTDF
Sbjct: 140 FTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFG-- 197
Query: 170 IKPKYLPEDNPGEYAFYFDTSQRRTCYLAPERFDTKRYNDETINKLEKEMDLFSLGCCLF 229
+ +++ ++ Y+F Y+AP D R D + +K +D +SLG ++
Sbjct: 198 LSKEFVADETERAYSFCGTIE-----YMAP---DIVRGGD---SGHDKAVDWWSLGVLMY 246
Query: 230 ELFTEGRP 237
EL T P
Sbjct: 247 ELLTGASP 254
>CE27768 [R] KOG0586 Serine/threonine protein kinase
Length = 1096
Score = 58.5 bits (140), Expect = 7e-08
Identities = 57/259 (22%), Positives = 113/259 (43%), Gaps = 34/259 (13%)
Query: 39 LKTCKALDPNGEIVVKVFLKPTESYDLKSIHDKIERQSLMLRQL--PNVLNYSKILYTDR 96
+K K + E+ +K+ K + S K+ R+ +++QL PN++ +++ T++
Sbjct: 136 VKLAKHVITGHEVAIKIIDKTALN---PSSLQKLFREVKIMKQLDHPNIVKLYQVMETEQ 192
Query: 97 AGYLIRQHLKTN-LYDRLSLRPFLQEIELKFMAFQLLQILADIHMRDITHGDIKTENIMV 155
YL+ ++ ++D L ++E E + Q++ + +H ++I H D+K EN+++
Sbjct: 193 TLYLVLEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYLHSKNIIHRDLKAENLLL 252
Query: 156 TSSNWLILTDFSEYIKPKYLPEDNPGEYAFYFDTSQRRTCYLAPERFDTKRYNDETINKL 215
+ + DF N DT Y APE F K+Y+
Sbjct: 253 DQDMNIKIADFG---------FSNTFSLGNKLDTFCGSPPYAAPELFSGKKYDG------ 297
Query: 216 EKEMDLFSLGCCLFELFTEGRPLFNLSQLFKYKNGENEALETIRSEIKDPVLQS-----L 270
E+D++SLG L+ L + P F +N + +R + + P S L
Sbjct: 298 -PEVDVWSLGVILYTLVSGSLP-------FDGQNLKELRERVLRGKYRIPFYMSTDCENL 349
Query: 271 ILDMIALNPEDRLSARTLL 289
+ + +NP+ R S ++
Sbjct: 350 LKKFLVINPQRRSSLDNIM 368
>CE23838 [R] KOG0586 Serine/threonine protein kinase
Length = 1192
Score = 58.5 bits (140), Expect = 7e-08
Identities = 57/259 (22%), Positives = 113/259 (43%), Gaps = 34/259 (13%)
Query: 39 LKTCKALDPNGEIVVKVFLKPTESYDLKSIHDKIERQSLMLRQL--PNVLNYSKILYTDR 96
+K K + E+ +K+ K + S K+ R+ +++QL PN++ +++ T++
Sbjct: 184 VKLAKHVITGHEVAIKIIDKTALN---PSSLQKLFREVKIMKQLDHPNIVKLYQVMETEQ 240
Query: 97 AGYLIRQHLKTN-LYDRLSLRPFLQEIELKFMAFQLLQILADIHMRDITHGDIKTENIMV 155
YL+ ++ ++D L ++E E + Q++ + +H ++I H D+K EN+++
Sbjct: 241 TLYLVLEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYLHSKNIIHRDLKAENLLL 300
Query: 156 TSSNWLILTDFSEYIKPKYLPEDNPGEYAFYFDTSQRRTCYLAPERFDTKRYNDETINKL 215
+ + DF N DT Y APE F K+Y+
Sbjct: 301 DQDMNIKIADFG---------FSNTFSLGNKLDTFCGSPPYAAPELFSGKKYDG------ 345
Query: 216 EKEMDLFSLGCCLFELFTEGRPLFNLSQLFKYKNGENEALETIRSEIKDPVLQS-----L 270
E+D++SLG L+ L + P F +N + +R + + P S L
Sbjct: 346 -PEVDVWSLGVILYTLVSGSLP-------FDGQNLKELRERVLRGKYRIPFYMSTDCENL 397
Query: 271 ILDMIALNPEDRLSARTLL 289
+ + +NP+ R S ++
Sbjct: 398 LKKFLVINPQRRSSLDNIM 416
>Hs4507277_1 [R] KOG0589 Serine/threonine protein kinase
Length = 292
Score = 58.2 bits (139), Expect = 9e-08
Identities = 63/243 (25%), Positives = 113/243 (45%), Gaps = 39/243 (16%)
Query: 73 ERQSLMLRQL--PNVLNYSKILYT-DRAGYLIRQHLKT-NLYDRLSLRP--FLQEIELKF 126
E+++ +L QL PN++ Y + D Y++ + +LY +L + L E ++
Sbjct: 51 EQEAQLLSQLKHPNIVTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPENQVVE 110
Query: 127 MAFQLLQILADIHMRDITHGDIKTENIMVTSSNWLILTDFSEYIKPKYLPEDNPGEYAFY 186
Q+ L +H + I H D+KT+N+ +T +N + + D + L +N + A
Sbjct: 111 WFVQIAMALQYLHEKHILHRDLKTQNVFLTRTNIIKVGDLG---IARVL--ENHCDMA-- 163
Query: 187 FDTSQRRTCYLAPERFDTKRYNDETINKLEKEMDLFSLGCCLFELFTEGRPLFNLSQLFK 246
T Y++PE F K YN ++ D+++LGCC++E+ T L F
Sbjct: 164 -STLIGTPYYMSPELFSNKPYNYKS--------DVWALGCCVYEMAT-------LKHAFN 207
Query: 247 YKNGENEALETIRSEIK------DPVLQSLILDMIALNPEDRLSARTLLS----KYKVTF 296
K+ + I ++ P L LI M++ PE+R S R++L K +++F
Sbjct: 208 AKDMNSLVYRIIEGKLPAMPRDYSPELAELIRTMLSKRPEERPSVRSILRQPYIKRQISF 267
Query: 297 FPE 299
F E
Sbjct: 268 FLE 270
>Hs6031180 [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and related
serine/threonine protein kinases
Length = 1558
Score = 57.8 bits (138), Expect = 1e-07
Identities = 55/214 (25%), Positives = 95/214 (43%), Gaps = 17/214 (7%)
Query: 41 TCKALDPNGEIVV--KVFLKPTESYDLKSIHDKIERQSLMLRQLPNVLNYSKILYTDRAG 98
TC ++D GE++ ++ +P + +K D+++ + PN++ Y +
Sbjct: 1309 TCISVD-TGELMAMKEIRFQPNDHKTIKETADELKIFEGIKH--PNLVRYFGVELHREEM 1365
Query: 99 YLIRQHLKTNLYDRLSLRPFLQEIELKFMAFQLLQILADIHMRDITHGDIKTENIMVTSS 158
Y+ ++ + +S R LQE ++ + Q+ + +H I H DIK NI +TSS
Sbjct: 1366 YIFMEYCDEGTLEEVS-RLGLQEHVIRLYSKQITIAINVLHEHGIVHRDIKGANIFLTSS 1424
Query: 159 NWLILTDFSEYIKPKYLPEDNPGEYAFYFDTSQRRTCYLAPERFDTKRYNDETINKLEKE 218
+ L DF +K K + PGE T+ Y+APE + +
Sbjct: 1425 GLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTA----AYMAPEVITRAKGEGH-----GRA 1475
Query: 219 MDLFSLGCCLFELFTEGRPLFNLSQLFK--YKNG 250
D++SLGC + E+ T RP F+ YK G
Sbjct: 1476 ADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVG 1509
>Hs5803088 [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and related
serine/threonine protein kinases
Length = 1607
Score = 57.8 bits (138), Expect = 1e-07
Identities = 55/214 (25%), Positives = 95/214 (43%), Gaps = 17/214 (7%)
Query: 41 TCKALDPNGEIVV--KVFLKPTESYDLKSIHDKIERQSLMLRQLPNVLNYSKILYTDRAG 98
TC ++D GE++ ++ +P + +K D+++ + PN++ Y +
Sbjct: 1358 TCISVD-TGELMAMKEIRFQPNDHKTIKETADELKIFEGIKH--PNLVRYFGVELHREEM 1414
Query: 99 YLIRQHLKTNLYDRLSLRPFLQEIELKFMAFQLLQILADIHMRDITHGDIKTENIMVTSS 158
Y+ ++ + +S R LQE ++ + Q+ + +H I H DIK NI +TSS
Sbjct: 1415 YIFMEYCDEGTLEEVS-RLGLQEHVIRLYSKQITIAINVLHEHGIVHRDIKGANIFLTSS 1473
Query: 159 NWLILTDFSEYIKPKYLPEDNPGEYAFYFDTSQRRTCYLAPERFDTKRYNDETINKLEKE 218
+ L DF +K K + PGE T+ Y+APE + +
Sbjct: 1474 GLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTA----AYMAPEVITRAKGEGH-----GRA 1524
Query: 219 MDLFSLGCCLFELFTEGRPLFNLSQLFK--YKNG 250
D++SLGC + E+ T RP F+ YK G
Sbjct: 1525 ADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVG 1558
>Hs5453882 [G] KOG0599 Phosphorylase kinase gamma subunit
Length = 387
Score = 57.8 bits (138), Expect = 1e-07
Identities = 52/216 (24%), Positives = 96/216 (44%), Gaps = 24/216 (11%)
Query: 83 PNVLNYSKILYTDRAGYLIRQHLKTN-LYDRLSLRPFLQEIELKFMAFQLLQILADIHMR 141
PN++ T+ +L+ +K L+D L+ + L E E + + LL+++ +H
Sbjct: 85 PNIIQLKDTYETNTFFFLVFDLMKRGELFDYLTEKVTLSEKETRKIMRALLEVICTLHKL 144
Query: 142 DITHGDIKTENIMVTSSNWLILTDFSEYIKPKYLPEDNPGEYAFYFDTSQRRTC----YL 197
+I H D+K ENI++ + + LTDF + + PGE R C YL
Sbjct: 145 NIVHRDLKPENILLDDNMNIKLTDFG------FSCQLEPGE-------RLREVCGTPSYL 191
Query: 198 APERFDTKRYNDETINKLEKEMDLFSLGCCLFELFTEGRPLFNLSQLFKYK---NGENEA 254
APE + D KE+D++S G ++ L P ++ Q+ + +G +
Sbjct: 192 APEIIECSMNEDHP--GYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQF 249
Query: 255 LETIRSEIKDPVLQSLILDMIALNPEDRLSARTLLS 290
+ D V + L+ + + P++R +A L+
Sbjct: 250 GSPEWDDYSDTV-KDLVSRFLVVQPQNRYTAEEALA 284
>7299437 [R] KOG0586 Serine/threonine protein kinase
Length = 604
Score = 57.8 bits (138), Expect = 1e-07
Identities = 72/325 (22%), Positives = 144/325 (44%), Gaps = 52/325 (16%)
Query: 33 LNSSRFLKTCKALD-PNGEIVVKVFLKPTESYDLKSI-HDKIERQSLMLRQL--PNVLNY 88
L F K A+ P G +V +K + L +I K+ R+ ++++L PN++
Sbjct: 69 LGKGNFAKVKLAIHLPTGR---EVAIKLIDKTALNTIARQKLYREVNIMKKLNHPNIVRL 125
Query: 89 SKILYTDRAGYLIRQHLKTN-LYDRLSLRPFLQEIELKFMAFQLLQILADIHMRDITHGD 147
+++ ++R YL+ +++ L++ L ++E + + + QL+ + H + I H D
Sbjct: 126 LQVIESERTLYLVMEYVSGGELFNYLVKNGRMRERDARVLFRQLVSAIEYCHSKSIVHRD 185
Query: 148 IKTENIMVTSSNWLILTD--FSEYIKPKYLPEDNPGEYAFYFDTSQRRTCYLAPERFDTK 205
+K EN+++ L + D FS +PK E G Y APE F K
Sbjct: 186 LKAENLLLDQQMKLKIADFGFSTTFEPKAPLETFCGS-----------PPYAAPELFRGK 234
Query: 206 RYNDETINKLEKEMDLFSLGCCLFELFTEGRPLFNLSQLFKYKNGENEALETIRSEIKDP 265
+Y+ E+D +SLG L+ L + P F+ + L + ++ +R + + P
Sbjct: 235 KYSG-------PEVDSWSLGVVLYTLVSGSLP-FDGTNLKELRD------RVLRGKYRVP 280
Query: 266 V-----LQSLILDMIALNPEDRLSARTLLSKYKVTFFPETFYSFIYEYYRNM----VQPA 316
+SLI + LNP R S +++ + + + YE + +P
Sbjct: 281 YYVSIECESLIRKFLVLNPTQRTSLSAVMA--------DRWINMGYEQGNGLRPFQEKPM 332
Query: 317 GLSNGNKTTMSLTLEERKRDLDTTV 341
L + N+ ++ + + RD++ ++
Sbjct: 333 DLHDVNRLSLLSNMGHKPRDVEQSL 357
>Hs4505569 [R] KOG0593 Predicted protein kinase KKIAMRE
Length = 493
Score = 57.4 bits (137), Expect = 2e-07
Identities = 58/202 (28%), Positives = 95/202 (46%), Gaps = 24/202 (11%)
Query: 42 CKALDPNGEIVVKVFLKPTESYDLKSIHDKIERQSLMLRQL--PNVLNYSKILYTDRAGY 99
C+ D + +K FL ES D K + R+ +L+QL N++N ++ + Y
Sbjct: 21 CRNKDTGRIVAIKKFL---ESDDDKMVKKIAMREIKLLKQLRHENLVNLLEVCKKKKRWY 77
Query: 100 LIRQHLKTNLYDRLSLRP--FLQEIELKFMAFQLLQILADIHMRDITHGDIKTENIMVTS 157
L+ + + + D L L P ++ K++ FQ++ + H +I H DIK ENI+V+
Sbjct: 78 LVFEFVDHTILDDLELFPNGLDYQVVQKYL-FQIINGIGFCHSHNIIHRDIKPENILVSQ 136
Query: 158 SNWLILTDFSEYIKPKYLPEDNPGEYAFYFDTSQRRTCYLAPERFDTKRYNDETINKLEK 217
S + L DF + + P + Y Y T Y APE D K K
Sbjct: 137 SGVVKLCDFG-FARTLAAPGE---VYTDYVAT----RWYRAPELL----VGDV---KYGK 181
Query: 218 EMDLFSLGCCLFELFTEGRPLF 239
+D++++GC + E+F G PLF
Sbjct: 182 AVDVWAIGCLVTEMFM-GEPLF 202
>YKL166c [T] KOG0616 cAMP-dependent protein kinase catalytic subunit (PKA)
Length = 398
Score = 57.0 bits (136), Expect = 2e-07
Identities = 57/238 (23%), Positives = 98/238 (40%), Gaps = 23/238 (9%)
Query: 48 NGEIVVKVFLKPTESYDLKSI-HDKIERQSLMLRQLPNVLNYSKILYTDRAGYLIRQHLK 106
NG LK LK + H ER+ L + P ++ + +++ +++
Sbjct: 110 NGRFYALKTLKKHTIVKLKQVEHTNDERRMLSIVSHPFIIRMWGTFQDSQQVFMVMDYIE 169
Query: 107 TN-LYDRLSLRPFLQEIELKFMAFQLLQILADIHMRDITHGDIKTENIMVTSSNWLILTD 165
L+ L KF A ++ L +H +DI + D+K ENI++ + + +TD
Sbjct: 170 GGELFSLLRKSQRFPNPVAKFYAAEVCLALEYLHSKDIIYRDLKPENILLDKNGHIKITD 229
Query: 166 FSEYIKPKYLPEDNPGEYAFYFDTSQRRTCYLAPERFDTKRYNDETINKLEKEMDLFSLG 225
F KY+P+ T Y+APE TK YN K +D +S G
Sbjct: 230 FG---FAKYVPD--------VTYTLCGTPDYIAPEVVSTKPYN--------KSVDWWSFG 270
Query: 226 CCLFELFTEGRPLFNLSQLFKYKNGENEALETIRSEIKDPVLQSLILDMIALNPEDRL 283
++E+ P +N + + Y+N N L+ P Q L+ +I + +RL
Sbjct: 271 VLIYEMLAGYTPFYNSNTMKTYENILNAELKF--PPFFHPDAQDLLKKLITRDLSERL 326
>CE27894_1 [R] KOG0589 Serine/threonine protein kinase
Length = 1011
Score = 57.0 bits (136), Expect = 2e-07
Identities = 55/230 (23%), Positives = 101/230 (43%), Gaps = 37/230 (16%)
Query: 66 KSIHDKIERQSLMLRQL--PNVLNYSKILYTDRAGYLIRQHLKTNLYDRLSLRPFL---- 119
KS D I ++ +QL PN++ Y +I + Y++ +L SLR +
Sbjct: 480 KSFGDMISEVKIIKQQLRHPNIVRYRRIFVENHRLYIVM-----DLIQGCSLRDLIITMK 534
Query: 120 ------QEIELKFMAFQLLQILADIHM-RDITHGDIKTENIMVTSSNWLILTDFSEYIKP 172
+E ++ M Q++ L +H + I H D+K NIM+T+ +++TDF +
Sbjct: 535 EKKGNFEEKKIWAMVVQMMLALRYLHKEKQIVHRDLKPNNIMMTTDERVVITDFG--LAK 592
Query: 173 KYLPEDNPGEYAFYFDTSQRRTCYLAPERFDTKRYNDETINKLEKEMDLFSLGCCLFELF 232
+ PE Y ++ Y PE Y ++ D++S GCC++E+
Sbjct: 593 QKGPE--------YLKSAAGTIIYSCPEIVQNLPYGEKA--------DIWSFGCCIYEM- 635
Query: 233 TEGRPLFNLSQLFKYKNGENEALETIRSEIKDPVLQSLILDMIALNPEDR 282
+ +P+F+ + + EA +E+ L+ LI +A +P R
Sbjct: 636 CQLQPVFHSTNMLTLAMQIVEAKYDPLNEMWSDDLRFLITSCLAPDPSAR 685
>SPBC4C3.11 [T] KOG0592 3-phosphoinositide-dependent protein kinase (PDK1)
Length = 420
Score = 56.2 bits (134), Expect = 4e-07
Identities = 62/265 (23%), Positives = 112/265 (41%), Gaps = 25/265 (9%)
Query: 33 LNSSRFLKTCKALDPNG--EIVVKVFLKPTESYDLKSIHDKIERQSLM-LRQLPNVLNYS 89
+ F K +A D E +KV K + K + IER S+M L P +
Sbjct: 60 IGDGSFSKVRRATDKKSWKEYAIKVLDKKYIVKENKVKYVNIERDSMMRLNGFPGISRLF 119
Query: 90 KILYTD-RAGYLIRQHLKTNLYDRLSLRPFLQEIELKFMAFQLLQILADIHMRDITHGDI 148
D + Y++ L + FL E ++F A ++L + +H I H D+
Sbjct: 120 HTFQDDLKLYYVLELAPNGELLQYIKKYRFLDENCVRFYAAEILSSIEYMHSCGIIHRDL 179
Query: 149 KTENIMVTSSNWLILTDF--SEYIKPKYLPEDNPGEYAFYFDTSQRRTCYLAPERFDTKR 206
K ENI+ + + +TDF ++ + PKY+ N +Y + + Y+APE +
Sbjct: 180 KPENILFDGNMHVKITDFGTAKILPPKYV---NSPDYTTFPSSFVGTAEYVAPELLSRQ- 235
Query: 207 YNDETINKLEKEMDLFSLGCCLFELFTEGRPLF---NLSQLFKYKNGENEALETIRSEIK 263
+ K DL++ C ++++ G P F N + +FK + +LE ++
Sbjct: 236 -------VVSKSSDLWAFACVVYQMIV-GSPPFHGSNPNNIFK----KIMSLEYELPKLL 283
Query: 264 DPVLQSLILDMIALNPEDRLSARTL 288
P + L + + P DR + + +
Sbjct: 284 PPDIVPLFSHLFRIQPSDRSTTQQI 308
>Hs18552621 [R] KOG0597 Serine-threonine protein kinase FUSED
Length = 1315
Score = 56.2 bits (134), Expect = 4e-07
Identities = 67/319 (21%), Positives = 128/319 (40%), Gaps = 50/319 (15%)
Query: 24 LDEVHYQSQLNSSRFLKTCKALDPNGEIVVKVFLKPTESYDLKSIHDKIERQSLMLRQL- 82
+++ H + F + K VV + P K + + ++R+ ++R L
Sbjct: 1 MEKYHVLEMIGEGSFGRVYKGRRKYSAQVVALKFIPKLGRSEKELRN-LQREIEIMRGLR 59
Query: 83 -PNVLNYSKILYTDRAGYLIRQHLKTNLYDRLSLRPFLQEIELKFMAFQLLQILADIHMR 141
PN+++ TD+ ++ + + L+ L L E +++ +A QL+ L +H
Sbjct: 60 HPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPEDQVQAIAAQLVSALYYLHSH 119
Query: 142 DITHGDIKTENIMVTSSNWLILTDFSEYIKPKYLPEDNPGEYAFYFDTSQRRTCYLAPER 201
I H D+K +NI++ + L DF + + + + Y++PE
Sbjct: 120 RILHRDMKPQNILLAKGGGIKLCDFG-FARAM-------STNTMVLTSIKGTPLYMSPEL 171
Query: 202 FDTKRYNDETINKLEKEMDLFSLGCCLFELFTEGRPLFNLSQLFKYKNGENEALETIRSE 261
+ + Y + DL+S+GC L+EL G P F + +F + +
Sbjct: 172 VEERPY--------DHTADLWSVGCILYEL-AVGTPPFYATSIF----------QLVSLI 212
Query: 262 IKDPV---------LQSLILDMIALNPEDRLSARTLLSKYKVTFFPETFYSFIYEYYRNM 312
+KDPV ++ + ++ +P RLS LL ++ FI + +
Sbjct: 213 LKDPVRWPSTISPCFKNFLQGLLTKDPRQRLSWPDLL-----------YHPFIAGHVTII 261
Query: 313 VQPAGLSNGNKTTMSLTLE 331
+PAG G T L E
Sbjct: 262 TEPAGPDLGTPFTSRLPPE 280
>Hs14728804 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 576
Score = 56.2 bits (134), Expect = 4e-07
Identities = 68/288 (23%), Positives = 119/288 (40%), Gaps = 56/288 (19%)
Query: 26 EVHYQSQ--LNSSRF--LKTCKALDPNGEIVVKVFLKPTESYDLKSIHDKIERQSLMLRQ 81
E HY++ + F +K C+ + +K+ K LK D ++ + L+++
Sbjct: 281 EKHYETGRVIGDGNFAVVKECRHRETRQAYAMKIIDKSR----LKGKEDMVDSEILIIQS 336
Query: 82 L--PNVLNYSKILYTDRAGYLIRQHLKT-NLYDRLSLRPFLQEIELKFMAFQLLQILADI 138
L PN++ ++ TD YLI ++++ +L+D + E + M L + L +
Sbjct: 337 LSHPNIVKLHEVYETDMEIYLILEYVQGGDLFDAIIESVKFPEPDAALMIMDLCKALVHM 396
Query: 139 HMRDITHGDIKTENIMV----TSSNWLILTDF---SEYIKPKYLPEDNPGEYAFYFDTSQ 191
H + I H D+K EN++V S L L DF ++P + P
Sbjct: 397 HDKSIVHRDLKPENLLVQRNEDKSTTLKLADFGLAKHVVRPIFTVCGTP----------- 445
Query: 192 RRTCYLAPERFDTKRYNDETINKLEKEMDLFSLGCCLFELFTEGRP----------LFNL 241
Y+APE K Y E+D+++ G L+ L P LFN+
Sbjct: 446 ---TYVAPEILSEKGYG--------LEVDMWAAGVILYILLCGFPPFRSPERDQDELFNI 494
Query: 242 SQLFKYKNGENEALETIRSEIKDPVLQSLILDMIALNPEDRLSARTLL 289
QL G E L I D + L+ ++ ++P+ R +A +L
Sbjct: 495 IQL-----GHFEFLPPYWDNISD-AAKDLVSRLLVVDPKKRYTAHQVL 536
>7294217 [D] KOG0588 Serine/threonine protein kinase
Length = 851
Score = 56.2 bits (134), Expect = 4e-07
Identities = 59/226 (26%), Positives = 99/226 (43%), Gaps = 29/226 (12%)
Query: 66 KSIHDKIERQSLMLRQL--PNVLNYSKILYTDRAGYLIRQHLKTN-LYDRLSLRPFLQEI 122
+S+ K+ER+ +++ + P+VL S + + YLI +H+ L+D L + L
Sbjct: 56 ESVLMKVEREIAIMKLIDHPHVLGLSDVYENKKYLYLILEHVSGGELFDYLVKKGRLTPK 115
Query: 123 ELKFMAFQLLQILADIHMRDITHGDIKTENIMVTSSNWLILTDFS-EYIKPKYLPEDNPG 181
E + Q++ L H I H D+K EN+++ N + + DF ++P
Sbjct: 116 EARKFFRQIISALDFCHSHSICHRDLKPENLLLDEKNNIKIADFGMASLQPA-------- 167
Query: 182 EYAFYFDTSQRRTCYLAPERFDTKRYNDETINKLEKEMDLFSLGCCLFELFTEGRPL--F 239
+TS Y PE ++Y+ ++ D++S G L+ L P
Sbjct: 168 --GSMLETSCGSPHYACPEVIRGEKYDG-------RKADVWSCGVILYALLVGALPFDDD 218
Query: 240 NLSQLF-KYKNGENEALETIRSEIKDPVLQSLILDMIALNPEDRLS 284
NL QL K K G + P QSL+ MI +NP+ RL+
Sbjct: 219 NLRQLLEKVKRGVFHIPHFV-----PPDCQSLLRGMIEVNPDRRLT 259
>7301004 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 411
Score = 55.8 bits (133), Expect = 5e-07
Identities = 57/232 (24%), Positives = 100/232 (42%), Gaps = 37/232 (15%)
Query: 16 AISSYVDVLDEVHYQSQLNSSRFLKTCKALDPNGEIVVKVFLKPTESYDLKSIHDKIERQ 75
AI Y++ ++ V + N+ + + + VK+ K T+S D + + E
Sbjct: 144 AIQLYIETIEPVEH----NTRTLIYRGQTRANRTKCTVKMVNKQTQSNDRGDTYMEAE-- 197
Query: 76 SLMLRQLPNVLNYSKILYT---DRAGYLIRQHLKTNLYDRLSLRPFLQEIELKFMAFQLL 132
+LRQL + N +++YT +R Y + +HL N+ + R L E + + + +
Sbjct: 198 --VLRQLQSHPNIIELMYTVEDERYMYTVLEHLDCNMQKVIQKRGILSEADARSVMRCTV 255
Query: 133 QILADIHMRDITHGDIKTENIMVTSSN--WLILTDFSEYIKPKYLPEDNPGEYAFYFDTS 190
LA +H + H DIK EN++V SS+ W +F + + A Y+ S
Sbjct: 256 SALAHMHQLQVIHRDIKPENLLVCSSSGKW----NFKMVKVANF-------DLATYYRGS 304
Query: 191 Q-----RRTCYLAPERFDTKRYNDETINKLEKEMDLFSLGCCLFELFTEGRP 237
+ CY+APE Y + ++D +SLG LF + P
Sbjct: 305 KLYVRCGTPCYMAPEMIAMSGY--------DYQVDSWSLGVTLFYMLCGKMP 348
>7297542 [T] KOG0616 cAMP-dependent protein kinase catalytic subunit (PKA)
Length = 353
Score = 55.8 bits (133), Expect = 5e-07
Identities = 62/236 (26%), Positives = 104/236 (43%), Gaps = 40/236 (16%)
Query: 58 KPTESYDLKSIHDKIERQSLMLRQLPNVLNYSKILYTDRAGYLI--RQHLK--TNLYDRL 113
KPT+ Y I DK ++ + L+Q+ + LN +IL + +L+ R H K +NLY L
Sbjct: 66 KPTKDYYAMKILDK--QKVVKLKQVEHTLNEKRILQAIQFPFLVSLRYHFKDNSNLYMVL 123
Query: 114 SLRPF------------LQEIELKFMAFQLLQILADIHMRDITHGDIKTENIMVTSSNWL 161
P E +F A Q++ +H D+ + D+K EN+++ S +L
Sbjct: 124 EYVPGGEMFSHLRKVGRFSEPHSRFYAAQIVLAFEYLHYLDLIYRDLKPENLLIDSQGYL 183
Query: 162 ILTDFSEYIKPKYLPEDNPGEYAFYFDTSQRRTCYLAPERFDTKRYNDETINKLEKEMDL 221
+TDF + K G T + YLAPE +K YN K +D
Sbjct: 184 KVTDFGFAKRVK-------GRTWTLCGTPE----YLAPEIILSKGYN--------KAVDW 224
Query: 222 FSLGCCLFELFTEGRPLFNLSQLFKYK---NGENEALETIRSEIKDPVLQSLILDM 274
++LG ++E+ P F + Y+ +G+ S++KD + L +D+
Sbjct: 225 WALGVLVYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFGSDLKDLLRNLLQVDL 280
>Hs20545245 [D] KOG0588 Serine/threonine protein kinase
Length = 795
Score = 55.5 bits (132), Expect = 6e-07
Identities = 61/225 (27%), Positives = 96/225 (42%), Gaps = 27/225 (12%)
Query: 66 KSIHDKIERQSLMLRQL--PNVLNYSKILYTDRAGYLIRQHLKTN-LYDRLSLRPFLQEI 122
+S+ K+ER+ +L+ + P+VL + + YL+ +H+ L+D L + L
Sbjct: 89 ESVLMKVEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPK 148
Query: 123 ELKFMAFQLLQILADIHMRDITHGDIKTENIMVTSSNWLILTDFSEYIKPKYLPEDNPGE 182
E + Q++ L H I H D+K EN+++ N + + DF + G+
Sbjct: 149 EARKFFRQIVSALDFCHSYSICHRDLKPENLLLDEKNNIRIADFG-------MASLQVGD 201
Query: 183 YAFYFDTSQRRTCYLAPERFDTKRYNDETINKLEKEMDLFSLGCCLFELFTEGRPL--FN 240
+TS Y PE ++Y+ + D++S G LF L P N
Sbjct: 202 --SLLETSCGSPHYACPEVIKGEKYDG-------RRADMWSCGVILFALLVGALPFDDDN 252
Query: 241 LSQLF-KYKNGENEALETIRSEIKDPVLQSLILDMIALNPEDRLS 284
L QL K K G I P QSL+ MI + PE RLS
Sbjct: 253 LRQLLEKVKRGVFHMPHFI-----PPDCQSLLRGMIEVEPEKRLS 292
>At4g18700 [T] KOG0583 Serine/threonine protein kinase
Length = 489
Score = 55.5 bits (132), Expect = 6e-07
Identities = 55/241 (22%), Positives = 108/241 (43%), Gaps = 31/241 (12%)
Query: 72 IERQSLMLRQL--PNVLNYSKILYTDRAGYLIRQHLKTN-LYDRLSLRPFLQEIELKFMA 128
I+R+ +LR++ PN++ +++ T Y + ++++ L+++++ +E+ K+
Sbjct: 71 IKREISILRRVRHPNIVQLFEVMATKAKIYFVMEYVRGGELFNKVAKGRLKEEVARKYFQ 130
Query: 129 FQLLQILADIHMRDITHGDIKTENIMVTSSNWLILTDFSEYIKPKYLPEDNPGEYAFYFD 188
QL+ + H R + H D+K EN+++ + L ++DF + +D F
Sbjct: 131 -QLISAVTFCHARGVYHRDLKPENLLLDENGNLKVSDFGLSAVSDQIRQDG------LFH 183
Query: 189 TSQRRTCYLAPERFDTKRYNDETINKLEKEMDLFSLGCCLFELFTEGRPLFNLSQLFKYK 248
T Y+APE K Y+ ++D++S G LF L P + + + YK
Sbjct: 184 TFCGTPAYVAPEVLARKGYD-------AAKVDIWSCGVILFVLMAGYLPFHDRNVMAMYK 236
Query: 249 NGENEALETIRSEIKDP-----VLQSLILDMIALNPEDRLSARTLL--SKYKVTFFPETF 301
+ R E + P L L+ ++ NPE R + ++ S +K F F
Sbjct: 237 -------KIYRGEFRCPRWFSTELTRLLSKLLETNPEKRFTFPEIMENSWFKKGFKHIKF 289
Query: 302 Y 302
Y
Sbjct: 290 Y 290
>At5g45810 [T] KOG0583 Serine/threonine protein kinase
Length = 483
Score = 55.1 bits (131), Expect = 8e-07
Identities = 54/241 (22%), Positives = 109/241 (44%), Gaps = 31/241 (12%)
Query: 72 IERQSLMLRQL--PNVLNYSKILYTDRAGYLIRQHLKTN-LYDRLSLRPFLQEIELKFMA 128
I+R+ +LR++ PN++ +++ T Y + +++K L+++++ +E+ K+
Sbjct: 73 IKREISILRRVRHPNIVQLFEVMATKSKIYFVMEYVKGGELFNKVAKGRLKEEMARKYFQ 132
Query: 129 FQLLQILADIHMRDITHGDIKTENIMVTSSNWLILTDFSEYIKPKYLPEDNPGEYAFYFD 188
QL+ ++ H R + H D+K EN+++ + L ++DF + +D F
Sbjct: 133 -QLISAVSFCHFRGVYHRDLKPENLLLDENGNLKVSDFGLSAVSDQIRQDG------LFH 185
Query: 189 TSQRRTCYLAPERFDTKRYNDETINKLEKEMDLFSLGCCLFELFTEGRPLFNLSQLFKYK 248
T Y+APE K Y+ ++D++S G LF L P + + + YK
Sbjct: 186 TFCGTPAYVAPEVLARKGYDG-------AKVDIWSCGVILFVLMAGFLPFHDRNVMAMYK 238
Query: 249 NGENEALETIRSEIKDP-----VLQSLILDMIALNPEDRLSARTLL--SKYKVTFFPETF 301
+ R + + P + L++ M+ PE R + ++ S +K F F
Sbjct: 239 -------KIYRGDFRCPRWFPVEINRLLIRMLETKPERRFTMPDIMETSWFKKGFKHIKF 291
Query: 302 Y 302
Y
Sbjct: 292 Y 292
>At4g14780 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 364
Score = 55.1 bits (131), Expect = 8e-07
Identities = 40/145 (27%), Positives = 67/145 (45%), Gaps = 22/145 (15%)
Query: 98 GYLIRQHLKTNLYDRLSLRPFLQEIELKFMAFQLLQILADIHMRDITHGDIKTENIMVTS 157
G ++QHL + +L+ + ++ +A L + L+ +H I H D+KTEN+++ +
Sbjct: 163 GGTLKQHLIRHKSKKLAFKAVIK------LALDLARGLSYLHSEKIVHRDVKTENMLLDA 216
Query: 158 SNWLILTDFSEYIKPKYLPEDNPGEYAFYFDTSQRRTCYLAPERFDTKRYNDETINKLEK 217
L + DF P+D GE Y+APE D K YN +
Sbjct: 217 QKNLKIADFGVARVEALNPKDMTGETG--------TLGYMAPEVIDGKPYN--------R 260
Query: 218 EMDLFSLGCCLFELFTEGRPLFNLS 242
D++S G CL+E++ P +LS
Sbjct: 261 RCDVYSFGICLWEIYCCDMPYPDLS 285
>Hs13899225 [R] KOG0586 Serine/threonine protein kinase
Length = 688
Score = 54.7 bits (130), Expect = 1e-06
Identities = 56/265 (21%), Positives = 115/265 (43%), Gaps = 38/265 (14%)
Query: 35 SSRFLKTCKALDPNGEIVVKVFLKPTESYDLKSIHDKIERQSLMLRQL--PNVLNYSKIL 92
+S +K + + E+ +K+ K + S K+ R+ +++ L PN++ +++
Sbjct: 69 NSAKVKLARHILTGREVAIKIIDKTQLN---PSSLQKLFREVRIMKGLNHPNIVKLFEVI 125
Query: 93 YTDRAGYLIRQHLKTN-LYDRLSLRPFLQEIELKFMAFQLLQILADIHMRDITHGDIKTE 151
T++ YL+ ++ ++D L ++E E + Q++ + H ++I H D+K E
Sbjct: 126 ETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAE 185
Query: 152 NIMVTSSNWLILTDFSEYIKPKYLPEDNPGEYAFYFDTSQRRTCYLAPERFDTKRYNDET 211
N+++ + + + DF N DT Y APE F K+Y+
Sbjct: 186 NLLLDAEANIKIADFG---------FSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDG-- 234
Query: 212 INKLEKEMDLFSLGCCLFELFTEGRPL--FNLSQLFKYKNGENEALETIRSEIKDPV--- 266
E+D++SLG L+ L + P NL +L + +R + + P
Sbjct: 235 -----PEVDIWSLGVILYTLVSGSLPFDGHNLKELRE---------RVLRGKYRVPFYMS 280
Query: 267 --LQSLILDMIALNPEDRLSARTLL 289
+S++ + LNP R + ++
Sbjct: 281 TDCESILRRFLVLNPAKRCTLEQIM 305
>7295638 [T] KOG0603 Ribosomal protein S6 kinase
Length = 911
Score = 54.7 bits (130), Expect = 1e-06
Identities = 52/194 (26%), Positives = 83/194 (41%), Gaps = 32/194 (16%)
Query: 99 YLIRQHLKT-NLYDRLSLRPFLQEIELKFMAFQLLQILADIHMRDITHGDIKTENIMVTS 157
YLI L+ +L+ RLS E ++KF +L + +H I + D+K ENI++
Sbjct: 275 YLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALAMNHLHTLGIIYRDLKPENILLDE 334
Query: 158 SNWLILTDFSEYIKPKYLPEDNPGEYAFYFDTSQRRTCYLAPERFDTKRYNDETINKLEK 217
+ LTDF +P D Y+F Y+APE + K + +
Sbjct: 335 HGHIALTDFGLSKQPL----DGSKTYSFCGTVE-----YMAPEIVNRKGH--------DF 377
Query: 218 EMDLFSLGCCLFELFTEGRPLF------NLSQLFKYKNGENEALETIRSEIKDPVLQSLI 271
D +S G ++E+ T P ++Q+ + K G E L P QSL+
Sbjct: 378 AADWWSFGVLMYEMLTGNLPFHGQTRQETMNQILRSKLGMPENL--------SPEAQSLL 429
Query: 272 LDMIALNPEDRLSA 285
+ NP++RL A
Sbjct: 430 RALFKRNPQNRLGA 443
>Hs9845489 [R] KOG0586 Serine/threonine protein kinase
Length = 691
Score = 54.3 bits (129), Expect = 1e-06
Identities = 55/241 (22%), Positives = 104/241 (42%), Gaps = 34/241 (14%)
Query: 50 EIVVKVFLKPTESYDLKSIHDKIERQSLMLRQL--PNVLNYSKILYTDRAGYLIRQHLKT 107
E+ VK+ K + S K+ R+ +++ L PN++ +++ T++ YL+ ++
Sbjct: 45 EVAVKIIDKTQLN---SSSLQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASG 101
Query: 108 N-LYDRLSLRPFLQEIELKFMAFQLLQILADIHMRDITHGDIKTENIMVTSSNWLILTDF 166
++D L ++E E + Q++ + H + I H D+K EN+++ + + + DF
Sbjct: 102 GEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADF 161
Query: 167 SEYIKPKYLPEDNPGEYAFYFDTSQRRTCYLAPERFDTKRYNDETINKLEKEMDLFSLGC 226
N + DT Y APE F K+Y+ E+D++SLG
Sbjct: 162 G---------FSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDG-------PEVDVWSLGV 205
Query: 227 CLFELFTEGRPLFNLSQLFKYKNGENEALETIRSEIKDPVLQS-----LILDMIALNPED 281
L+ L + P F +N + +R + + P S L+ + LNP
Sbjct: 206 ILYTLVSGSLP-------FDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSK 258
Query: 282 R 282
R
Sbjct: 259 R 259
>Hs9845487 [R] KOG0586 Serine/threonine protein kinase
Length = 745
Score = 54.3 bits (129), Expect = 1e-06
Identities = 55/241 (22%), Positives = 104/241 (42%), Gaps = 34/241 (14%)
Query: 50 EIVVKVFLKPTESYDLKSIHDKIERQSLMLRQL--PNVLNYSKILYTDRAGYLIRQHLKT 107
E+ VK+ K + S K+ R+ +++ L PN++ +++ T++ YL+ ++
Sbjct: 45 EVAVKIIDKTQLN---SSSLQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASG 101
Query: 108 N-LYDRLSLRPFLQEIELKFMAFQLLQILADIHMRDITHGDIKTENIMVTSSNWLILTDF 166
++D L ++E E + Q++ + H + I H D+K EN+++ + + + DF
Sbjct: 102 GEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADF 161
Query: 167 SEYIKPKYLPEDNPGEYAFYFDTSQRRTCYLAPERFDTKRYNDETINKLEKEMDLFSLGC 226
N + DT Y APE F K+Y+ E+D++SLG
Sbjct: 162 G---------FSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDG-------PEVDVWSLGV 205
Query: 227 CLFELFTEGRPLFNLSQLFKYKNGENEALETIRSEIKDPVLQS-----LILDMIALNPED 281
L+ L + P F +N + +R + + P S L+ + LNP
Sbjct: 206 ILYTLVSGSLP-------FDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSK 258
Query: 282 R 282
R
Sbjct: 259 R 259
>Hs22062450 [R] KOG0586 Serine/threonine protein kinase
Length = 787
Score = 54.3 bits (129), Expect = 1e-06
Identities = 55/241 (22%), Positives = 104/241 (42%), Gaps = 34/241 (14%)
Query: 50 EIVVKVFLKPTESYDLKSIHDKIERQSLMLRQL--PNVLNYSKILYTDRAGYLIRQHLKT 107
E+ VK+ K + S K+ R+ +++ L PN++ +++ T++ YL+ ++
Sbjct: 78 EVAVKIIDKTQLN---SSSLQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASG 134
Query: 108 N-LYDRLSLRPFLQEIELKFMAFQLLQILADIHMRDITHGDIKTENIMVTSSNWLILTDF 166
++D L ++E E + Q++ + H + I H D+K EN+++ + + + DF
Sbjct: 135 GEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADF 194
Query: 167 SEYIKPKYLPEDNPGEYAFYFDTSQRRTCYLAPERFDTKRYNDETINKLEKEMDLFSLGC 226
N + DT Y APE F K+Y+ E+D++SLG
Sbjct: 195 G---------FSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDG-------PEVDVWSLGV 238
Query: 227 CLFELFTEGRPLFNLSQLFKYKNGENEALETIRSEIKDPVLQS-----LILDMIALNPED 281
L+ L + P F +N + +R + + P S L+ + LNP
Sbjct: 239 ILYTLVSGSLP-------FDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSK 291
Query: 282 R 282
R
Sbjct: 292 R 292
>Hs4759050 [T] KOG0603 Ribosomal protein S6 kinase
Length = 740
Score = 53.9 bits (128), Expect = 2e-06
Identities = 57/225 (25%), Positives = 92/225 (40%), Gaps = 31/225 (13%)
Query: 68 IHDKIERQSLMLRQLPNVLNYSKILYTDRAGYLIRQHLKT-NLYDRLSLRPFLQEIELKF 126
+ K+ER L+ P ++ T+ YLI L+ +L+ RLS E ++KF
Sbjct: 113 VRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKF 172
Query: 127 MAFQLLQILADIHMRDITHGDIKTENIMVTSSNWLILTDFSEYIKPKYLPEDNPGEYAFY 186
+L L +H I + D+K ENI++ + LTDF K + Y+F
Sbjct: 173 YLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFG---LSKESIDHEKKAYSFC 229
Query: 187 FDTSQRRTCYLAPERFDTKRYNDETINKLEKEMDLFSLGCCLFELFTEGRPL------FN 240
Y+APE + + + + D +S G +FE+ T P
Sbjct: 230 GTVE-----YMAPEVVNRRGHT--------QSADWWSFGVLMFEMLTGTLPFQGKDRKET 276
Query: 241 LSQLFKYKNGENEALETIRSEIKDPVLQSLILDMIALNPEDRLSA 285
++ + K K G + L P QSL+ + NP +RL A
Sbjct: 277 MTMILKAKLGMPQFL--------SPEAQSLLRMLFKRNPANRLGA 313
>At1g30270 [T] KOG0583 Serine/threonine protein kinase
Length = 480
Score = 53.9 bits (128), Expect = 2e-06
Identities = 51/211 (24%), Positives = 94/211 (44%), Gaps = 18/211 (8%)
Query: 39 LKTCKALDPNGEIVVKVFLKPTESYDLKSIHDKIERQSLMLRQLPNVLNYSKILYTDRAG 98
+K + ++ + +KV K + K E ++ L + PNV+ +++ +
Sbjct: 45 VKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMFEVMASKTKI 104
Query: 99 YLIRQHLKTN-LYDRLSLRPFLQEIELKFMAFQLLQILADIHMRDITHGDIKTENIMVTS 157
Y + + + L+D++S L+E E + QL+ + H R + H D+K EN+++ +
Sbjct: 105 YFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDA 164
Query: 158 SNWLILTDFSEYIKPKYLPEDNPGEYAFYFDTSQRRTCYLAPERFDTKRYNDETINKLEK 217
+ L ++DF LP+ G T+ Y+APE + K Y+
Sbjct: 165 NGALKVSDFG----LSALPQQEDG----LLHTTCGTPNYVAPEVINNKGYDG-------A 209
Query: 218 EMDLFSLGCCLFELFTEGRPL--FNLSQLFK 246
+ DL+S G LF L P NL+ L+K
Sbjct: 210 KADLWSCGVILFVLMAGYLPFEDSNLTSLYK 240
>Hs7657526 [T] KOG0603 Ribosomal protein S6 kinase
Length = 745
Score = 53.5 bits (127), Expect = 2e-06
Identities = 66/285 (23%), Positives = 111/285 (38%), Gaps = 34/285 (11%)
Query: 38 FLKTCKALDPNGEIVVKVFLKPTESYDLKSIHDKIERQSLMLRQLPNVLNYSKILYTDRA 97
FL K G++ LK + K+ER L+ P ++ T+
Sbjct: 88 FLVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGK 147
Query: 98 GYLIRQHLKT-NLYDRLSLRPFLQEIELKFMAFQLLQILADIHMRDITHGDIKTENIMVT 156
YLI L+ +++ RLS E ++KF +L L +H I + D+K ENI++
Sbjct: 148 LYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLD 207
Query: 157 SSNWLILTDFSEYIKPKYLPEDNPGEYAFYFDTSQRRTCYLAPERFDTKRYNDETINKLE 216
+ LTDF K + Y+F Y+APE + + ++
Sbjct: 208 EIGHIKLTDFG---LSKESVDQEKKAYSFCGTVE-----YMAPEVVNRRGHS-------- 251
Query: 217 KEMDLFSLGCCLFELFTEGRPL------FNLSQLFKYKNGENEALETIRSEIKDPVLQSL 270
+ D +S G +FE+ T P ++ + K K G + L QSL
Sbjct: 252 QSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSA--------EAQSL 303
Query: 271 ILDMIALNPEDRLSARTLLSKYKVTFFPETFYSFIYEYYRNMVQP 315
+ + NP +RL + + + FF + + Y+ VQP
Sbjct: 304 LRMLFKRNPANRLGSEGVEEIKRHLFFANIDWD---KLYKREVQP 345
>Hs19923464 [T] KOG0577 Serine/threonine protein kinase
Length = 898
Score = 53.5 bits (127), Expect = 2e-06
Identities = 50/192 (26%), Positives = 83/192 (43%), Gaps = 29/192 (15%)
Query: 62 SYDLKSIHDK---IERQSLMLRQL--PNVLNYSKILYTDRAGYLIRQHLKTNLYDRLSL- 115
SY K H+K I ++ LRQL PN + Y + +L+ ++ + D L +
Sbjct: 56 SYSGKQTHEKWQDILKEVKFLRQLKHPNTIEYKGCYLKEHTAWLVMEYCLGSASDLLEVH 115
Query: 116 RPFLQEIELKFMAFQLLQILADIHMRDITHGDIKTENIMVTSSNWLILTDFSEYIKPKYL 175
+ LQE+E+ + L LA +H + H DIK NI++T + L DF
Sbjct: 116 KKPLQEVEIAAITHGALHGLAYLHSHALIHRDIKAGNILLTEPGQVKLADFGS------- 168
Query: 176 PEDNPGEYAFYFDTSQRRTCYLAPE---RFDTKRYNDETINKLEKEMDLFSLGCCLFELF 232
A ++ ++APE D +Y + ++D++SLG EL
Sbjct: 169 -----ASMASPANSFVGTPYWMAPEVILAMDEGQY--------DGKVDIWSLGITCIELA 215
Query: 233 TEGRPLFNLSQL 244
PLFN++ +
Sbjct: 216 ERKPPLFNMNAM 227
>At5g57630 [T] KOG0583 Serine/threonine protein kinase
Length = 412
Score = 53.5 bits (127), Expect = 2e-06
Identities = 58/247 (23%), Positives = 114/247 (45%), Gaps = 41/247 (16%)
Query: 66 KSIHDKIERQSLMLRQL--PNVLNYSKILYTDRAGYLIRQHLKTN-LYDRLSLRPFLQEI 122
K + +++R+ ++ L PN++ +++ T ++ +++ L DRL R ++E
Sbjct: 51 KGLESQVKREIRTMKLLNHPNIVQIHEVIGTKTKICIVMEYVSGGQLSDRLG-RQKMKES 109
Query: 123 ELKFMAFQLLQILADIHMRDITHGDIKTENIMVTSSNWLILTDFSEYIKPKYLPEDNPGE 182
+ + + QL+ + H R + H D+K +N+++ S L ++DF PK G+
Sbjct: 110 DARKLFQQLIDAVDYCHNRGVYHRDLKPQNLLLDSKGNLKVSDFGLSAVPK------SGD 163
Query: 183 YAFYFDTSQRRTCYLAPERFDTKRYNDETINKLEKEMDLFSLGCCLFELFTEGRPLFN-- 240
T+ CY+APE K Y+ + D++S G LFEL G P F+
Sbjct: 164 ---MLSTACGSPCYIAPELIMNKGYSGAAV-------DVWSCGVILFELLA-GYPPFDDH 212
Query: 241 -LSQLFKYKNGENEALETIRSEIKDP-----VLQSLILDMIALNPEDRLSARTLLSK--- 291
L L+K + +R++ P + LI +++ NP R++ ++ K
Sbjct: 213 TLPVLYK---------KILRADYTFPPGFTGEQKRLIFNILDPNPLSRITLAEIIIKDSW 263
Query: 292 YKVTFFP 298
+K+ + P
Sbjct: 264 FKIGYTP 270
>At3g29160 [T] KOG0583 Serine/threonine protein kinase
Length = 512
Score = 53.5 bits (127), Expect = 2e-06
Identities = 56/230 (24%), Positives = 102/230 (44%), Gaps = 24/230 (10%)
Query: 54 KVFLKPTESYDLKSIH--DKIERQSLMLRQL--PNVLNYSKILYTDRAGYLIRQHLKTN- 108
KV +K +K++ +K+ R+ +LR P+++ +++ T Y++ +++K+
Sbjct: 45 KVAIKILNRRKIKNMEMEEKVRREIKILRLFMHPHIIRQYEVIETTSDIYVVMEYVKSGE 104
Query: 109 LYDRLSLRPFLQEIELKFMAFQLLQILADIHMRDITHGDIKTENIMVTSSNWLILTDFSE 168
L+D + + LQE E + Q++ + H + H D+K EN+++ S + + DF
Sbjct: 105 LFDYIVEKGRLQEDEARNFFQQIISGVEYCHRNMVVHRDLKPENLLLDSRCNIKIADFG- 163
Query: 169 YIKPKYLPEDNPGEYAFYFDTSQRRTCYLAPERFDTKRYNDETINKLEKEMDLFSLGCCL 228
N + TS Y APE K Y E+D++S G L
Sbjct: 164 --------LSNVMRDGHFLKTSCGSPNYAAPEVISGKLY-------AGPEVDVWSCGVIL 208
Query: 229 FELFTEGRPL--FNLSQLF-KYKNGENEALETIRSEIKDPVLQSLILDMI 275
+ L P N+ LF K K G + SE +D + + LI+D +
Sbjct: 209 YALLCGTLPFDDENIPNLFKKIKGGIYTLPSHLSSEARDLIPRMLIVDPV 258
>At3g22750 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 378
Score = 53.5 bits (127), Expect = 2e-06
Identities = 41/145 (28%), Positives = 66/145 (45%), Gaps = 22/145 (15%)
Query: 98 GYLIRQHLKTNLYDRLSLRPFLQEIELKFMAFQLLQILADIHMRDITHGDIKTENIMVTS 157
G ++Q+L N +L+ + +Q +A L + L+ +H I H D+KTEN+++
Sbjct: 177 GGTLKQYLFRNRRKKLAFKVVVQ------LALDLSRGLSYLHSERIVHRDVKTENMLLDY 230
Query: 158 SNWLILTDFSEYIKPKYLPEDNPGEYAFYFDTSQRRTCYLAPERFDTKRYNDETINKLEK 217
L + DF P+D GE Y+APE D K YN +
Sbjct: 231 QRNLKIADFGVARVEAQNPKDMTGETG--------TLGYMAPEVLDGKPYN--------R 274
Query: 218 EMDLFSLGCCLFELFTEGRPLFNLS 242
D++S G CL+E++ P +LS
Sbjct: 275 RCDVYSFGICLWEIYCCDMPYPDLS 299
>At2g25090 [T] KOG0583 Serine/threonine protein kinase
Length = 469
Score = 53.5 bits (127), Expect = 2e-06
Identities = 66/294 (22%), Positives = 123/294 (41%), Gaps = 28/294 (9%)
Query: 23 VLDEVHYQSQLNSSRFLKTCKA--LDPNGEIVVKVFLKPTESYDLKSIHDKIERQSLMLR 80
+ D+ + L + F K + ++ +KV +K + + + ++IER+ ++R
Sbjct: 11 LFDKYNIGRLLGTGNFAKVYHGTEISTGDDVAIKV-IKKDHVFKRRGMMEQIEREIAVMR 69
Query: 81 QL--PNVLNYSKILYTDRAGYLIRQHLKTN-LYDRLSLRPFLQEIELKFMAFQLLQILAD 137
L PNV+ +++ T + + + +++ L++ + L E + QL+ +
Sbjct: 70 LLRHPNVVELREVMATKKKIFFVMEYVNGGELFEMIDRDGKLPEDLARKYFQQLISAVDF 129
Query: 138 IHMRDITHGDIKTENIMVTSSNWLILTDFSEYIKPKYLPEDNPGEYAFYFDTSQRR---T 194
H R + H DIK EN+++ L +TDF + +PE G D R
Sbjct: 130 CHSRGVFHRDIKPENLLLDGEGDLKVTDFG--LSALMMPEGLGGRRGSSDDLLHTRCGTP 187
Query: 195 CYLAPERFDTKRYNDETINKLEKEMDLFSLGCCLFELFTEGRPLF--NLSQLF-KYKNGE 251
Y+APE K Y+ D++S G L+ L P N+ L+ K E
Sbjct: 188 AYVAPEVLRNKGYDGAM-------ADIWSCGIVLYALLAGFLPFIDENVMTLYTKIFKAE 240
Query: 252 NEALETIRSEIKDPVLQSLILDMIALNPEDRLSAR--TLLSKYKVTFFPETFYS 303
E E K+ + + L+ D PE R+S ++ ++ F P +S
Sbjct: 241 CEFPPWFSLESKELLSRLLVPD-----PEQRISMSEIKMIPWFRKNFTPSVAFS 289
>Hs8923922 [R] KOG0586 Serine/threonine protein kinase
Length = 795
Score = 53.1 bits (126), Expect = 3e-06
Identities = 56/248 (22%), Positives = 105/248 (41%), Gaps = 38/248 (15%)
Query: 50 EIVVKVFLKPTESYDLKSIHDKIERQSLMLRQL--PNVLNYSKILYTDRAGYLIRQHLKT 107
+I+ K L PT K+ R+ +++ L PN++ +++ T++ YL+ ++
Sbjct: 89 KIIDKTQLNPTSL-------QKLFREVRIMKILNHPNIVKLFEVIETEKTLYLVMEYASG 141
Query: 108 N-LYDRLSLRPFLQEIELKFMAFQLLQILADIHMRDITHGDIKTENIMVTSSNWLILTDF 166
++D L ++E E + Q++ + H + I H D+K EN+++ + + DF
Sbjct: 142 GEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYIVHRDLKAENLLLDGDMNIKIADF 201
Query: 167 SEYIKPKYLPEDNPGEYAFYFDTSQRRTCYLAPERFDTKRYNDETINKLEKEMDLFSLGC 226
N DT Y APE F K+Y+ E+D++SLG
Sbjct: 202 G---------FSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDG-------PEVDVWSLGV 245
Query: 227 CLFELFTEGRPLFNLSQLFKYKNGENEALETIRSEIKDPVLQS-----LILDMIALNPED 281
L+ L + P F +N + +R + + P S L+ ++ LNP
Sbjct: 246 ILYTLVSGSLP-------FDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNPIK 298
Query: 282 RLSARTLL 289
R S ++
Sbjct: 299 RGSLEQIM 306
>Hs5730055 [D] KOG0575 Polo-like serine/threonine protein kinase
Length = 685
Score = 53.1 bits (126), Expect = 3e-06
Identities = 48/177 (27%), Positives = 81/177 (45%), Gaps = 28/177 (15%)
Query: 113 LSLRPFLQEIELKFMAFQLLQILADIHMRDITHGDIKTENIMVTSSNWLILTDFSEYIKP 172
L R L E E+++ Q++ L +H ++I H D+K N + + L + DF +
Sbjct: 171 LKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINEAMELKVGDFGLAARL 230
Query: 173 KYLPEDNPGEYAFYFDTSQRRTC-----YLAPERFDTKRYNDETINKLEKEMDLFSLGCC 227
+ L +RRT YL+PE + + + E+ D+++LGC
Sbjct: 231 EPLEH-------------RRRTICGTPNYLSPEVLNKQGHGCES--------DIWALGCV 269
Query: 228 LFELFTEGRPLFNLSQLFKYKNGENEALETIRSEIKDPVLQSLILDMIALNPEDRLS 284
++ + GRP F + L + EA T+ S + P + LI M++ NPEDR S
Sbjct: 270 MYTMLL-GRPPFETTNLKETYRCIREARYTMPSSLLAPA-KHLIASMLSKNPEDRPS 324
>Hs20479818 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 514
Score = 53.1 bits (126), Expect = 3e-06
Identities = 60/244 (24%), Positives = 112/244 (45%), Gaps = 41/244 (16%)
Query: 72 IERQSLMLRQLPN--VLNYSKILYTDRAGYLIRQHLKTN-LYDRLSLRPFLQEIELKFMA 128
+ER+ +L+ + + +++ ++ T + YL+ + + L + L + E E +++
Sbjct: 160 LEREVNILKSVKHEHIIHLEQVFETPKKMYLVMELCEDGELKEILDRKGHFSENETRWII 219
Query: 129 FQLLQILADIHMRDITHGDIKTENIMVTSS--------NWLI-LTDFSEYIKPKYLPEDN 179
L +A +H DI H D+K ENIMV SS N I +TDF +K + E
Sbjct: 220 QSLASAIAYLHNNDIVHRDLKLENIMVKSSLIDDNNEINLNIKVTDFGLAVKKQSRSE-- 277
Query: 180 PGEYAFYFDTSQRRTC----YLAPERFDTKRYNDETINKLEKEMDLFSLGCCLFELFTEG 235
+ TC Y+APE Y+ ++ D++S+G ++ L G
Sbjct: 278 ---------AMLQATCGTPIYMAPEVISAHDYS--------QQCDIWSIGVVMYMLL-RG 319
Query: 236 RPLFNLS---QLFK-YKNGENEALETIRSEIKDPVLQSLILDMIALNPEDRLSARTLLSK 291
P F S +LF+ + GE + + I D +S++ ++ ++P R++A+ LL
Sbjct: 320 EPPFLASSEEKLFELIRKGELHFENAVWNSISD-CAKSVLKQLMKVDPAHRITAKELLDN 378
Query: 292 YKVT 295
+T
Sbjct: 379 QWLT 382
>CE18169 [T] KOG0603 Ribosomal protein S6 kinase
Length = 797
Score = 53.1 bits (126), Expect = 3e-06
Identities = 53/221 (23%), Positives = 95/221 (42%), Gaps = 29/221 (13%)
Query: 71 KIERQSLMLRQLPNVLNYSKILYTDRAGYLIRQHLKT-NLYDRLSLRPFLQEIELKFMAF 129
K+ER L P ++ T+ YLI L+ +L+ RLS E ++KF
Sbjct: 152 KLERNILAHISHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEDDVKFYLA 211
Query: 130 QLLQILADIHMRDITHGDIKTENIMVTSSNWLILTDFSEYIKPKYLPEDNPGEYAFYFDT 189
+L L +H I + D+K ENI++ + + +TDF K + Y+F
Sbjct: 212 ELTLALEHLHSLGIVYRDLKPENILLDADGHIKVTDFG---LSKEAIDSEKKTYSFCGTV 268
Query: 190 SQRRTCYLAPERFDTKRYNDETINKLEKEMDLFSLGCCLFELFTEGRPLFNLSQLFKYKN 249
Y+APE + + ++ D +SLG +FE+ T P F+ ++
Sbjct: 269 E-----YMAPEVINRRGHS--------MAADFWSLGVLMFEMLTGHLP-------FQGRD 308
Query: 250 GENEALETIRSEIKDP-----VLQSLILDMIALNPEDRLSA 285
+ + +++++ P QSL+ + N ++RL A
Sbjct: 309 RNDTMTQILKAKLSMPHFLTQEAQSLLRALFKRNSQNRLGA 349
>CE13014 [T] KOG0603 Ribosomal protein S6 kinase
Length = 740
Score = 53.1 bits (126), Expect = 3e-06
Identities = 53/221 (23%), Positives = 95/221 (42%), Gaps = 29/221 (13%)
Query: 71 KIERQSLMLRQLPNVLNYSKILYTDRAGYLIRQHLKT-NLYDRLSLRPFLQEIELKFMAF 129
K+ER L P ++ T+ YLI L+ +L+ RLS E ++KF
Sbjct: 95 KLERNILAHISHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEDDVKFYLA 154
Query: 130 QLLQILADIHMRDITHGDIKTENIMVTSSNWLILTDFSEYIKPKYLPEDNPGEYAFYFDT 189
+L L +H I + D+K ENI++ + + +TDF K + Y+F
Sbjct: 155 ELTLALEHLHSLGIVYRDLKPENILLDADGHIKVTDFG---LSKEAIDSEKKTYSFCGTV 211
Query: 190 SQRRTCYLAPERFDTKRYNDETINKLEKEMDLFSLGCCLFELFTEGRPLFNLSQLFKYKN 249
Y+APE + + ++ D +SLG +FE+ T P F+ ++
Sbjct: 212 E-----YMAPEVINRRGHS--------MAADFWSLGVLMFEMLTGHLP-------FQGRD 251
Query: 250 GENEALETIRSEIKDP-----VLQSLILDMIALNPEDRLSA 285
+ + +++++ P QSL+ + N ++RL A
Sbjct: 252 RNDTMTQILKAKLSMPHFLTQEAQSLLRALFKRNSQNRLGA 292
>Hs8922679 [R] KOG0275 Conserved WD40 repeat-containing protein
Length = 513
Score = 52.8 bits (125), Expect = 4e-06
Identities = 55/229 (24%), Positives = 102/229 (44%), Gaps = 34/229 (14%)
Query: 1025 KFISSLSDH-KPAPVTAVAANNYKP---YIVTGSDDGFLKIWDLS--KIEKGSTFKPVVN 1078
KF + LS H K + V + P Y+VTGS DGF+++W+ + KI K ++ N
Sbjct: 200 KFPTQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDN 259
Query: 1079 H-ELGSSIVDITFIANYDVFVVSANDGSINLFKINFKNHITNREIQCIENLRHFTFKEAK 1137
+ +++ + F + ++ A DG I ++KI + QC+ F+ A
Sbjct: 260 FMMMDDAVLCMCFSRDTEMLATGAQDGKIKVWKI--------QSGQCLRR-----FERAH 306
Query: 1138 EYG-TSLSYTNDDSKPWIITVTNHGRIVMLDIRDMSVVHQIVIXXXXXXXXXXXXXXDGH 1196
G T LS++ D S+ I++ + I + ++ + + DGH
Sbjct: 307 SKGVTCLSFSKDSSQ--ILSASFDQTIRIHGLKSGKTLKE--FRGHSSFVNEATFTQDGH 362
Query: 1197 WLLCGTTHGALLLWNL-------TFKILVKSWCFGDESPIRKVILFQKD 1238
+++ ++ G + +WN+ TFK L + G + + VIL K+
Sbjct: 363 YIISASSDGTVKIWNMKTTECSNTFKSLGST--AGTDITVNSVILLPKN 409
>CE28482 [S] KOG1408 WD40 repeat protein
Length = 1693
Score = 52.8 bits (125), Expect = 4e-06
Identities = 46/172 (26%), Positives = 79/172 (45%), Gaps = 13/172 (7%)
Query: 1042 AANNYKPYIVTGSDDGFLKIWDLSKI-EKGSTFKPVVNHELGSSIVDITFIANYDVFVVS 1100
A+NN + ++ T + D L IW LS ++ F V + SSI D+ FI + D+FVV+
Sbjct: 592 ASNNGQLHLYTAASDRSLIIWKLSSFSDQHCEFTRVQMISVASSIGDMNFIKHVDLFVVA 651
Query: 1101 ANDGSINLFKINFKNHITNREIQCIENLRHFTFKEAKEYGTSLSYTNDDSKPWIITVTNH 1160
+D + F IN K T RE++ ++ + G L D S + I+V +
Sbjct: 652 GHDRMLRQFDINGK---TVREVKGTDD-------DVAHSGKILKVAIDHSGSYAISVCSD 701
Query: 1161 GRIVMLDIRDMSVVHQIVIXXXXXXXXXXXXXXDGHWLLCGTTHGALLLWNL 1212
+ + D+R S V V+ D ++ T++G++ +W L
Sbjct: 702 KFVYVTDLR--SGVCLAVLCGFGAPATDATFSDDFKNVIVTTSNGSIFIWQL 751
>CE20142 [T] KOG0592 3-phosphoinositide-dependent protein kinase (PDK1)
Length = 320
Score = 52.8 bits (125), Expect = 4e-06
Identities = 55/253 (21%), Positives = 115/253 (44%), Gaps = 16/253 (6%)
Query: 46 DPNGEIVVKVFLKPT--ESYDLKSIHDKIERQSLMLRQL---PNVLNYSKILYTDRAGYL 100
D N E+ +K+ LK ++ + IH + E +L+ R+ P ++ + Y
Sbjct: 51 DENPEVALKICLKRLILKNKMVPYIHREKEALALISREENAHPGIVTLYATFQDSESLYF 110
Query: 101 IRQHLKT-NLYDRLSLRPF--LQEIELKFMAFQLLQILADIHMRDITHGDIKTENIMVTS 157
+ ++ K +L + +P + ++ A LL L IH I H D+K +N++V S
Sbjct: 111 VLEYAKYGDLCTLMQKQPDSKFNVADSRYYAANLLSALEHIHKLGIIHRDVKADNLLVKS 170
Query: 158 SNWLILTDF--SEYIKPKYLPEDNPGEYAFYFDTSQRRTCYLAPERFDTKRYNDETINKL 215
++LTDF S+++ ++NP E + RR+ ++ F T T +++
Sbjct: 171 DGRIMLTDFGSSKFLSDYQKIQENPVEEE---QPTGRRSSFVGTAFFVTPEL--LTGSEM 225
Query: 216 EKEMDLFSLGCCLFELFTEGRPLFNLSQLFKYKNGENEALETIRSEIKDPVLQSLILDMI 275
DL++ L+ T P ++S+ ++ + + L T + D ++LI ++
Sbjct: 226 SPSSDLWAFSVTLYLFLTGIYPFNDMSEYLVFRRIQ-DILYTFSEDFPDENAKNLIERLL 284
Query: 276 ALNPEDRLSARTL 288
+ RL+++ +
Sbjct: 285 VKEQKSRLTSQEI 297
>CE06762 [T] KOG0660 Mitogen-activated protein kinase
Length = 367
Score = 52.8 bits (125), Expect = 4e-06
Identities = 72/305 (23%), Positives = 135/305 (43%), Gaps = 45/305 (14%)
Query: 42 CKALDPNGEIVVKVFLKPTESYDLKSIHDKIERQSLMLRQL--PNVLNYSKILYTDRAG- 98
CKA+D + V + P ++ ++ + R+ +LR+L N++ + + A
Sbjct: 72 CKAMDTRNKKQVAIKKIP-RAFTAHTLAKRSLREVRILRELLHENIIAVLDMFTAEGAHG 130
Query: 99 ---YLIRQHLKTNLYDRLSLRPFLQEIELKFMAFQLLQILADIHMRDITHGDIKTENIMV 155
YL+ ++T+L+ L R L E ++ +QLL+ L +H I H D+K N+++
Sbjct: 131 KDIYLVMDLMETDLHQILHSRQTLMEQHFQYFFYQLLRGLKYLHSAGIIHRDLKPSNLLL 190
Query: 156 TSSNWLILTDFS---EYIKPKYLPED-NPGEYAFYFDTSQRRTCYLAPE-RFDTKRYNDE 210
L + DF Y + +D N G + + +++ Y APE F Y
Sbjct: 191 NGDCLLRIADFGMARAYASASTVRDDANVGGHMTQYVSTR---WYRAPEILFSMVEY--- 244
Query: 211 TINKLEKEMDLFSLGCCLFELFTEGRPLF----NLSQL----FKYKNGENEALETIRSE- 261
+ ++DL+S GC E+ R LF ++SQ+ + + E E + I S+
Sbjct: 245 -----DTKVDLWSAGCIFAEMLLR-RQLFPGKDSVSQIKMIVYYLGSPEEEVINRITSDL 298
Query: 262 IKDPVL---QSLILDMIALNPEDRLSARTLLSKYKVTFFPETFYS--------FIYEYYR 310
++D + + L A+ P+ AR ++S Y + P YS F+ +Y+
Sbjct: 299 VRDSIEACGRKTPLPFSAIFPKASPEARNMVS-YLLQISPWKRYSADQILQHPFMAQYHN 357
Query: 311 NMVQP 315
+ +P
Sbjct: 358 DQYEP 362
>Hs19311016_1 [R] KOG0589 Serine/threonine protein kinase
Length = 330
Score = 52.8 bits (125), Expect = 4e-06
Identities = 61/240 (25%), Positives = 107/240 (44%), Gaps = 30/240 (12%)
Query: 64 DLKSIHDKIERQSLMLRQLPNVLNYSKIL-----YTDRAGYLIRQHLKT--NLYDRLSLR 116
DL + +K R +L + +L + I+ + D LI NLYD++ +
Sbjct: 84 DLTRLSEKERRDALNEIVILALLQHDNIIAYYNHFMDNTTLLIELEYCNGGNLYDKILRQ 143
Query: 117 P--FLQEIELKFMAFQLLQILADIHMRDITHGDIKTENIMVTSSNWLILTDFSEYIKPKY 174
+E + + FQ++ ++ IH I H DIKT NI +T +N + L D+
Sbjct: 144 KDKLFEEEMVVWYLFQIVSAVSCIHKAGILHRDIKTLNIFLTKANLIKLGDYG------- 196
Query: 175 LPEDNPGEYAFYFDTSQRRTCYLAPERFDTKRYNDETINKLEKEMDLFSLGCCLFELFTE 234
L + EY+ +T Y++PE +YN ++ D++++GC +FEL T
Sbjct: 197 LAKKLNSEYSM-AETLVGTPYYMSPELCQGVKYNFKS--------DIWAVGCVIFELLTL 247
Query: 235 GRPLFNLSQL---FKYKNGENEALETIRSEIKDPVLQSLILDMIALNPEDRLSARTLLSK 291
R + L K G A+E S+ ++Q ++ + +PE R +A LL +
Sbjct: 248 KRTFDATNPLNLCVKIVQG-IRAMEVDSSQYSLELIQ-MVHSCLDQDPEQRPTADELLDR 305
>YDR466w [T] KOG0592 3-phosphoinositide-dependent protein kinase (PDK1)
Length = 898
Score = 52.4 bits (124), Expect = 5e-06
Identities = 75/337 (22%), Positives = 137/337 (40%), Gaps = 63/337 (18%)
Query: 29 YQSQLNSSRFLKTCKALD---PNGEIVVKVFLKPTESYDLKSIHDKIERQSLMLRQLPNV 85
++ +L + KALD PN +KV K + K + IE+ ++ L +
Sbjct: 13 FKEELGHGSYSTVFKALDKKSPNKIYAIKVCSKKHIIKEAKVKYVTIEKNTMNLLAQKHH 72
Query: 86 LNYSKILYTDRAGYLIRQHLKTNLYDRLSLRP------------FLQEIELKFMAFQLLQ 133
K+ YT H + NLY L P +I + QL+
Sbjct: 73 AGIIKLYYTF--------HDEENLYFVLDFAPGGELLSLLHKMGTFNDIWTRHFTAQLID 124
Query: 134 ILADIHMRDITHGDIKTENIMVTSSNWLILTDF--SEYIKP-------KYLPEDNPGE-- 182
L IH I H D+K EN+++ L++TDF + I P K+ + N +
Sbjct: 125 ALEFIHSHGIIHRDLKPENVLLDRDGRLMITDFGAAATIDPSLSGDSAKFNSDSNGSKDN 184
Query: 183 --YAFYFDTSQRRTCYLAPERFDTKRYNDETINKLEKEMDLFSLGCCLFELFTEGRPLFN 240
A + T++ Y++PE N+ D+++LGC +++ F +G+P F
Sbjct: 185 QNCASFVGTAE----YVSPELL--------LYNQCGYGSDIWALGCMIYQ-FVQGQPPFR 231
Query: 241 LSQLFK---------YKNGENEALETIRSEIKDPVLQSLILDMIALNPEDRLSARTLLSK 291
K Y G N + S I +P++ +L+ ++ + +R+S +
Sbjct: 232 GENELKTFEKIVALDYPWGPNNRINNSTSPI-NPLVINLVQKILVIEVNERISLEQI--- 287
Query: 292 YKVTFFPETFYSFIYEYYRNMVQPAGLSNGNKTTMSL 328
+ +F + ++ + +R + Q G S +TT+ L
Sbjct: 288 KRHPYFSKVDWNDKIKIWRGIWQSQGQSL-QQTTLGL 323
>YCR073c [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and related
serine/threonine protein kinases
Length = 1331
Score = 52.4 bits (124), Expect = 5e-06
Identities = 51/205 (24%), Positives = 87/205 (41%), Gaps = 16/205 (7%)
Query: 48 NGEIVVKVFLKPTESYDLKSIHDKIERQSLMLRQL--PNVLNYSKI-LYTDRAGYLIRQH 104
NGEI+ +K ++ +K I I+ + +L L PN++ Y + ++ D+ +
Sbjct: 1056 NGEILAVKEIKIHDTTTMKKIFPLIKEEMTVLEMLNHPNIVQYYGVEVHRDKVNIFMEYC 1115
Query: 105 LKTNLYDRLSLRPFLQEIELKFMAFQLLQILADIHMRDITHGDIKTENIMVTSSNWLILT 164
+L L E+ + F+LL+ LA +H + H DIK ENI++ + +
Sbjct: 1116 EGGSLASLLDHGRIEDEMVTQVYTFELLEGLAYLHQSGVVHRDIKPENILLDFNGIIKYV 1175
Query: 165 DFS---EYIKPKYLPEDNPGEYAFYFDTSQRR-----TCYLAPERFDTKRYNDETINKLE 216
DF + + N F +T Y+APE KL
Sbjct: 1176 DFGTARTVVGSRTRTVRNAAVQDFGVETKSLNEMMGTPMYMAPETIS----GSAVKGKLG 1231
Query: 217 KEMDLFSLGCCLFELFTEGRPLFNL 241
+ D+++LGC + E+ T RP NL
Sbjct: 1232 AD-DVWALGCVVLEMATGRRPWSNL 1255
>SPAC31G5.09c [T] KOG0660 Mitogen-activated protein kinase
Length = 372
Score = 52.4 bits (124), Expect = 5e-06
Identities = 39/141 (27%), Positives = 70/141 (48%), Gaps = 14/141 (9%)
Query: 99 YLIRQHLKTNLYDRLSLRPFLQEIELKFMAFQLLQILADIHMRDITHGDIKTENIMVTSS 158
Y++++ ++T+LY + +P L + ++ +Q+L+ L +H + H D+K N+++ ++
Sbjct: 116 YIVQELMETDLYRVIRSQP-LSDDHCQYFTYQILRALKAMHSAGVVHRDLKPSNLLLNAN 174
Query: 159 NWLILTDFSEYIKPKYLPEDNPGEYAFYFDTSQRRTCYLAPERFDTKRYNDETINKLEKE 218
L + DF + NPG Y T Y APE + R + K
Sbjct: 175 CDLKVADFG-LARSTTAQGGNPGFMTEYVAT----RWYRAPEIMLSFR-------EYSKA 222
Query: 219 MDLFSLGCCLFELFTEGRPLF 239
+DL+S GC L E+ + RPLF
Sbjct: 223 IDLWSTGCILAEMLS-ARPLF 242
>Hs7657214 [T] KOG0583 Serine/threonine protein kinase
Length = 714
Score = 52.4 bits (124), Expect = 5e-06
Identities = 56/231 (24%), Positives = 101/231 (43%), Gaps = 25/231 (10%)
Query: 50 EIVVKVFLKPT---ESYDLKSIHDKIERQSLMLRQLPNVLNYSKILYTDRAGYLIRQHLK 106
++ +KV K ++Y K++ + + Q ++ PN+ IL T+ + YL+ +
Sbjct: 87 KVAIKVIDKKRAKKDTYVTKNLRREGQIQQMIRH--PNITQLLDILETENSYYLVMELCP 144
Query: 107 T-NLYDRLSLRPFLQEIELKFMAFQLLQILADIHMRDITHGDIKTENIMVTSSNWLILTD 165
NL ++ + L+E E + QL+ + +H + H D+K EN+++ N + L D
Sbjct: 145 GGNLMHKIYEKKRLEESEARRYIRQLISAVEHLHRAGVVHRDLKIENLLLDEDNNIKLID 204
Query: 166 FSEYIKPKYLPEDNPGEYAFYFDTSQRRTCYLAPERFDTKRYNDETINKLEKEMDLFSLG 225
F L +P F T Y APE K+Y ++D++S+G
Sbjct: 205 FGLSNCAGILGYSDP------FSTQCGSPAYAAPELLARKKYG--------PKIDVWSIG 250
Query: 226 CCLFELFTEGRPL----FNLSQLF-KYKNGENEALETIRSEIKDPVLQSLI 271
++ + T P F+L L+ K + E L T S L+SL+
Sbjct: 251 VNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQLSTGAISFLRSLL 301
>Hs20547806 [R] KOG0589 Serine/threonine protein kinase
Length = 489
Score = 52.4 bits (124), Expect = 5e-06
Identities = 49/160 (30%), Positives = 74/160 (45%), Gaps = 29/160 (18%)
Query: 138 IHMRDITHGDIKTENIMVTSSNWLILTDFSEYIKPKYLPEDNPGEYAFYFDTSQRRTCYL 197
IH + + H DIK++NI +T + + L DF + L NP +A T Y+
Sbjct: 118 IHKKRVLHRDIKSKNIFLTQNGKVKLGDFG---SARLL--SNPMAFAC---TYVGTPYYV 169
Query: 198 APERFDTKRYNDETINKLEKEMDLFSLGCCLFELFTEGRPLFNLSQLFKYKNGENEALET 257
PE ++ YN+++ D++SLGC L+EL T P F+ + +N L+
Sbjct: 170 PPEIWENLPYNNKS--------DIWSLGCILYELCTLKHP-------FQANSWKNLILKV 214
Query: 258 IRSEIK------DPVLQSLILDMIALNPEDRLSARTLLSK 291
+ I LQ L+ M NP R SA TLLS+
Sbjct: 215 CQGCISPLPSHYSYELQFLVKQMFKRNPSHRPSATTLLSR 254
>7299536 [D] KOG0580 Serine/threonine protein kinase
Length = 411
Score = 52.4 bits (124), Expect = 5e-06
Identities = 63/248 (25%), Positives = 101/248 (40%), Gaps = 47/248 (18%)
Query: 51 IVVKVFLKPT--ESYDLKSIHDKIERQSLMLRQLPNVLNYSKILYTDRAGYLIRQHL-KT 107
+ +KV K ES + +IE QS + P++L + D YLI ++ +
Sbjct: 180 VALKVLFKRQIGESNVEHQVRREIEIQSHLRH--PHILRLYAYFHDDVRIYLILEYAPQG 237
Query: 108 NLYDRLSLRPFLQEIELKFMAF--QLLQILADIHMRDITHGDIKTENIMVTSSNWLILTD 165
L++ L +P + E + + L L +H RDI H DIK EN+++ L + D
Sbjct: 238 TLFNALQAQPMKRFDERQSATYIQALCSALLYLHERDIIHRDIKPENLLLGHKGVLKIAD 297
Query: 166 FSEYIKPKYLPEDNPGEYAFYFDTSQRRTC-----YLAPERFDTKRYNDETINKLEKEMD 220
F ++ + S R T YL PE K + K +D
Sbjct: 298 FG---------------WSVHEPNSMRMTLCGTVDYLPPEMVQGKPHT--------KNVD 334
Query: 221 LFSLGCCLFELFTEGRPLFNLSQLFKYKNGENEALETIRSEIKDP-----VLQSLILDMI 275
L+SLG FEL P ++ KN + + ++ + K P LI ++
Sbjct: 335 LWSLGVLCFELLVGHAPFYS-------KNYDETYKKILKVDYKLPEHISKAASHLISKLL 387
Query: 276 ALNPEDRL 283
LNP+ RL
Sbjct: 388 VLNPQHRL 395
>7299438 [R] KOG0586 Serine/threonine protein kinase
Length = 705
Score = 52.4 bits (124), Expect = 5e-06
Identities = 69/326 (21%), Positives = 142/326 (43%), Gaps = 41/326 (12%)
Query: 33 LNSSRFLKTCKALD-PNG-EIVVKVFLKPTESYDLKSIHDKIERQSLMLRQL--PNVLNY 88
L F K A+ P G E+ +KV K + S K+ R+ +++ L PN++
Sbjct: 104 LGKGNFAKVKLAIHVPTGREVAIKVIDKTQLN---TSARQKLYREVKIMKLLNHPNIVRL 160
Query: 89 SKILYTDRAGYLIRQHL-KTNLYDRLSLRPFLQEIELKFMAFQLLQILADIHMRDITHGD 147
+++ ++R YL+ ++ + L+D L ++E + + + QL+ + H + + H D
Sbjct: 161 FQVIESERTLYLVMEYASRGELFDHLVKNGRMRERDARVIFRQLVSAIQYCHSKFVVHRD 220
Query: 148 IKTENIMVTSSNWLILTDFSEYIKPKYLPEDNPGEYAFYFDTSQRRTCYLAPERFDTKRY 207
+K EN+++ + + DF N + +T Y APE F ++Y
Sbjct: 221 LKAENLLLDQHMNIKIADFG---------FGNTFDPNAQLETFCGSPPYAAPELFMGRKY 271
Query: 208 NDETINKLEKEMDLFSLGCCLFELFTEGRPLFNLSQLFKYKNGENEALETIRSEIKDPV- 266
E+D +SLG L+ L + P F+ L + + +R + + P
Sbjct: 272 -------AGPEVDAWSLGVVLYTLVSGSLP-FDGGTLKELRE------RVLRGKYRVPYY 317
Query: 267 ----LQSLILDMIALNPEDRLSARTLLSKYKVTFFPETFYSFIYEYYRNMVQPAGLSNGN 322
++L+ + LNP R S ++S + + S +R +P L +
Sbjct: 318 ISMDCENLMRKFLVLNPAKRTSLSAVMSDKWINLGHDE--SDRLRPFRE--KPMELQDAA 373
Query: 323 KTTMSLTLEERKRDLDTTVT-KIFKD 347
+ + +++ ++RD++ +V ++F D
Sbjct: 374 RFDLLMSMGHKRRDVEQSVKGQLFDD 399
>YBL016w [T] KOG0660 Mitogen-activated protein kinase
Length = 353
Score = 52.0 bits (123), Expect = 7e-06
Identities = 54/228 (23%), Positives = 97/228 (41%), Gaps = 22/228 (9%)
Query: 22 DVLDEVHYQSQLNSSRFLKTCKALD-PNGEIVVKVFLKPTESYDLKSIHDKIERQSLMLR 80
++ + +S L + C A P GEIV +K E +D + R+ +L+
Sbjct: 8 NISSDFQLKSLLGEGAYGVVCSATHKPTGEIVA---IKKIEPFDKPLFALRTLREIKILK 64
Query: 81 QLP--NVLNYSKILYTD-----RAGYLIRQHLKTNLYDRLSLRPFLQEIELKFMAFQLLQ 133
N++ I D Y+I++ ++T+L+ +S + L + +++ +Q L+
Sbjct: 65 HFKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQ-MLSDDHIQYFIYQTLR 123
Query: 134 ILADIHMRDITHGDIKTENIMVTSSNWLILTDF--SEYIKPKYLPEDNPGEYAFYFDTSQ 191
+ +H ++ H D+K N+++ S+ L + DF + I P
Sbjct: 124 AVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYV 183
Query: 192 RRTCYLAPERFDTKRYNDETINKLEKEMDLFSLGCCLFELFTEGRPLF 239
Y APE T K + MD++S GC L ELF RP+F
Sbjct: 184 ATRWYRAPEVMLTSA-------KYSRAMDVWSCGCILAELFLR-RPIF 223
>SPCC320.12c [D] KOG0580 Serine/threonine protein kinase
Length = 384
Score = 52.0 bits (123), Expect = 7e-06
Identities = 56/227 (24%), Positives = 99/227 (42%), Gaps = 26/227 (11%)
Query: 66 KSIHDKIERQSLMLRQLPNVLNYSKILYTDRAGYLIRQHL-KTNLYDRLS-LRPFLQEIE 123
K + +IE QS + + N+L + ++ YLI + + LY L + F +E+
Sbjct: 161 KQVRREIEIQSNLRHK--NILRLYGHFHDEKRIYLILEFAGRGELYQHLRRAKRFSEEVA 218
Query: 124 LKFMAFQLLQILADIHMRDITHGDIKTENIMVTSSNWLILTDFSEYIKPKYLPEDNPGEY 183
K++ FQ+ L+ +H + + H DIK ENI++ + L+DF + + P +
Sbjct: 219 SKYI-FQMANALSYLHKKHVIHRDIKPENILLGIDGEIKLSDFGWSV---HAPSNRRTTL 274
Query: 184 AFYFDTSQRRTCYLAPERFDTKRYNDETINKLEKEMDLFSLGCCLFELFTEGRPLFNLS- 242
D YL PE + K + + ++DL+SLG +E P ++S
Sbjct: 275 CGTLD-------YLPPEMVEGKEHTE--------KVDLWSLGVLTYEFLVGAPPFEDMSG 319
Query: 243 QLFKYKNGENEALETIRSEIKDPVLQSLILDMIALNPEDRLSARTLL 289
YK L+ P + LI ++ NPE R+S ++
Sbjct: 320 HSATYKRIAKVDLKI--PSFVPPDARDLISRLLQHNPEKRMSLEQVM 364
>SPAC24B11.06c [T] KOG0660 Mitogen-activated protein kinase
Length = 349
Score = 52.0 bits (123), Expect = 7e-06
Identities = 51/193 (26%), Positives = 90/193 (46%), Gaps = 28/193 (14%)
Query: 51 IVVKVFLKPTESYDLKSIHDKIERQSLMLRQL--PNVLNYSKILYTDRAG-YLIRQHLKT 107
+ VK +KP + + + R+ +L+ L N+++ S I + Y + + L T
Sbjct: 46 VAVKKIMKP---FSTPVLAKRTYRELKLLKHLRHENIISLSDIFISPFEDIYFVTELLGT 102
Query: 108 NLYDRLSLRPFLQEIELKFMAFQLLQILADIHMRDITHGDIKTENIMVTSSNWLILTDFS 167
+L+ L+ RP L+ +++ +Q+L+ L +H + H D+K NI++ + L + DF
Sbjct: 103 DLHRLLTSRP-LETQFIQYFLYQILRGLKFVHSAGVIHRDLKPSNILINENCDLKICDFG 161
Query: 168 EYIKPKYLPEDNPGEYAFYFDTSQRRTCYLAPERFDT-KRYNDETINKLEKEMDLFSLGC 226
L + Y T Y APE T ++YN E+D++S GC
Sbjct: 162 -------LARIQDPQMTGYVSTRY----YRAPEIMLTWQKYN--------VEVDIWSAGC 202
Query: 227 CLFELFTEGRPLF 239
E+ EG+PLF
Sbjct: 203 IFAEMI-EGKPLF 214
>Hs4506089 [T] KOG0660 Mitogen-activated protein kinase
Length = 557
Score = 52.0 bits (123), Expect = 7e-06
Identities = 49/182 (26%), Positives = 83/182 (44%), Gaps = 23/182 (12%)
Query: 92 LYTDRAGYLIRQHLKTNLYDRLSLRPFLQEIELKFMAFQLLQILADIHMRDITHGDIKTE 151
L+ Y+++++++T+L RL + L E K +QLL+ L IH ++ H D+K
Sbjct: 95 LFKFSVAYIVQEYMETDLA-RLLEQGTLAEEHAKLFMYQLLRGLKYIHSANVLHRDLKPA 153
Query: 152 NIMVTSSNWLI-LTDFSEYIKPKYLPEDNPGEYAFYFDTSQRRTCYLAPERFDTKRYNDE 210
NI +++ + ++ + DF A D YL+ E TK Y
Sbjct: 154 NIFISTEDLVLKIGDFG---------------LARIVDQHYSHKGYLS-EGLVTKWYRSP 197
Query: 211 TI----NKLEKEMDLFSLGCCLFELFTEGRPLFNLSQLFKYKNGENEALETIRSEIKDPV 266
+ N K +D+++ GC L E+ T GR LF + + E + IR E KD +
Sbjct: 198 RLLLSPNNYTKAIDMWAAGCILAEMLT-GRMLFAGAHELEQMQLILETIPVIREEDKDEL 256
Query: 267 LQ 268
L+
Sbjct: 257 LR 258
>SPBC32C12.03c [T] KOG0583 Serine/threonine protein kinase
Length = 423
Score = 51.6 bits (122), Expect = 9e-06
Identities = 59/223 (26%), Positives = 99/223 (43%), Gaps = 32/223 (14%)
Query: 71 KIERQSLMLRQL--PNVLNYSKILYTDRAGYLIRQHLKTN-LYDRLSLRPFLQEIELKFM 127
+++R++L+ R L PN+ + T Y++ +++ L + + R L E +
Sbjct: 96 RVQREALLGRLLRHPNICRVIDCIRTPACTYILFEYVPGGQLLEYILARGKLDEDLARSF 155
Query: 128 AFQLLQILADIHMRDITHGDIKTENIMVT-SSNWLILTDFSEYIKPKYLPEDNPGEY--A 184
A QL+ L +H I H D+K EN+++T S + L DF + Y +D Y +
Sbjct: 156 AMQLINALVYLHKNFIVHRDLKIENVLLTQDSRQVKLIDFG--LSNFYSKDDLLRTYCGS 213
Query: 185 FYFDTSQRRTCYLAPERFDTKRYNDETINKLEKEMDLFSLGCCLFELFTEGRPLFNLSQL 244
YF APE D K Y + E+D++SLG ++ + P ++S
Sbjct: 214 LYF---------AAPELLDAKPY-------IGPEVDVWSLGVVIYVMVCGRVPFDDVSVP 257
Query: 245 F---KYKNGENEALETIRSEIKDPVLQSLILDMIALNPEDRLS 284
K K+G+ E I + SLI M+ +NP R S
Sbjct: 258 MLHSKIKSGKLEFPSYISED-----CCSLIAAMLNVNPRKRCS 295
>HsM4505103 [R] KOG0586 Serine/threonine protein kinase
Length = 713
Score = 51.6 bits (122), Expect = 9e-06
Identities = 56/241 (23%), Positives = 101/241 (41%), Gaps = 38/241 (15%)
Query: 50 EIVVKVFLKPTESYDLKSIHDKIERQSLMLRQL--PNVLNYSKILYTDRAGYLIRQHLKT 107
+I+ K L PT K+ R+ +++ L PN++ +++ T + YLI ++
Sbjct: 85 KIIDKTQLNPTSL-------QKLFREVRIMKILNHPNIVKLFEVIETQKTLYLIMEYASG 137
Query: 108 N-LYDRLSLRPFLQEIELKFMAFQLLQILADIHMRDITHGDIKTENIMVTSSNWLILTDF 166
++D L ++E E + Q++ + H + I H D+K EN+++ + + + DF
Sbjct: 138 GKVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADF 197
Query: 167 SEYIKPKYLPEDNPGEYAFYFDTSQRRTCYLAPERFDTKRYNDETINKLEKEMDLFSLGC 226
N DT Y APE F K+Y+ E+D++SLG
Sbjct: 198 G---------FSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDG-------PEVDVWSLGV 241
Query: 227 CLFELFTEGRPLFNLSQLFKYKNGENEALETIRSEIKDPVLQS-----LILDMIALNPED 281
L+ L + P F +N + +R + + P S L+ + LNP
Sbjct: 242 ILYTLVSGSLP-------FDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIK 294
Query: 282 R 282
R
Sbjct: 295 R 295
>Hs19923570 [T] KOG0603 Ribosomal protein S6 kinase
Length = 733
Score = 51.6 bits (122), Expect = 9e-06
Identities = 57/243 (23%), Positives = 99/243 (40%), Gaps = 29/243 (11%)
Query: 49 GEIVVKVFLKPTESYDLKSIHDKIERQSLMLRQLPNVLNYSKILYTDRAGYLIRQHLKT- 107
G++ LK + K+ER L P ++ T+ YLI L+
Sbjct: 85 GQLYAMKVLKKATLKVRDRVRSKMERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGG 144
Query: 108 NLYDRLSLRPFLQEIELKFMAFQLLQILADIHMRDITHGDIKTENIMVTSSNWLILTDFS 167
+L+ RLS E ++KF +L L +H I + D+K ENI++ + +TDF
Sbjct: 145 DLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFG 204
Query: 168 EYIKPKYLPEDNPGEYAFYFDTSQRRTCYLAPERFDTKRYNDETINKLEKEMDLFSLGCC 227
K + + Y+F Y+APE + + + + D +S G
Sbjct: 205 ---LSKEAIDHDKRAYSFCGTIE-----YMAPEVVNRRGHT--------QSADWWSFGVL 248
Query: 228 LFELFTEGRPLFNLSQLFKYKNGENEALETIRSEIKDPVL-----QSLILDMIALNPEDR 282
+FE+ T P F+ K+ + +++++ P QSL+ + NP +R
Sbjct: 249 MFEMLTGSLP-------FQGKDRKETMALILKAKLGMPQFLSGEAQSLLRALFKRNPCNR 301
Query: 283 LSA 285
L A
Sbjct: 302 LGA 304
>At5g58380 [T] KOG0583 Serine/threonine protein kinase
Length = 464
Score = 51.6 bits (122), Expect = 9e-06
Identities = 50/221 (22%), Positives = 102/221 (45%), Gaps = 25/221 (11%)
Query: 70 DKIERQSLMLR--QLPNVLNYSKILYTDRAGYLIRQHLKTN-LYDRLSLRPFLQEIELKF 126
++I+R+ ++R + PNV+ +++ T Y + ++ K L+++++ ++ K+
Sbjct: 55 EQIKREISVMRIARHPNVVELYEVMATKTRIYFVMEYCKGGELFNKVAKGKLRDDVAWKY 114
Query: 127 MAFQLLQILADIHMRDITHGDIKTENIMVTSSNWLILTDFSEYIKPKYLPEDNPGEYAFY 186
+QL+ + H R++ H DIK EN+++ + L ++DF +D
Sbjct: 115 F-YQLINAVDFCHSREVYHRDIKPENLLLDDNENLKVSDFGLSALADCKRQDG------L 167
Query: 187 FDTSQRRTCYLAPERFDTKRYNDETINKLEKEMDLFSLGCCLFELFTEGRPLF--NLSQL 244
T+ Y+APE + K Y+ + D++S G LF L P NL ++
Sbjct: 168 LHTTCGTPAYVAPEVINRKGYDG-------TKADIWSCGVVLFVLLAGYLPFHDSNLMEM 220
Query: 245 F-KYKNGENEALETIRSEIKDPVLQSLILDMIALNPEDRLS 284
+ K + +A E++ L+ M+ NPE R++
Sbjct: 221 YRKIGKADFKAPSWFAPEVR-----RLLCKMLDPNPETRIT 256
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.320 0.136 0.395
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 79,018,997
Number of Sequences: 60738
Number of extensions: 3288808
Number of successful extensions: 11739
Number of sequences better than 1.0e-05: 82
Number of HSP's better than 0.0 without gapping: 6
Number of HSP's successfully gapped in prelim test: 76
Number of HSP's that attempted gapping in prelim test: 11589
Number of HSP's gapped (non-prelim): 120
length of query: 1412
length of database: 30,389,216
effective HSP length: 119
effective length of query: 1293
effective length of database: 23,161,394
effective search space: 29947682442
effective search space used: 29947682442
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)