ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactII3121 good D KOG2513 Cell cycle control, cell division, chromosome partitioning Protein required for meiotic chromosome segregation
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactII3121 1072379 1074949 857
(857 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YBR086c [D] KOG2513 Protein required for meiotic chromosome segr... 389 e-107
SPBP22H7.01c [D] KOG2513 Protein required for meiotic chromosome... 119 2e-26
Hs8922384 [D] KOG2513 Protein required for meiotic chromosome se... 79 2e-14
Hs20480633 [S] KOG2514 Uncharacterized conserved protein 64 1e-09
7300532 [S] KOG2514 Uncharacterized conserved protein 62 5e-09
7292713 [S] KOG2514 Uncharacterized conserved protein 58 7e-08
Hs22062168 [S] KOG2514 Uncharacterized conserved protein 53 2e-06
>YBR086c [D] KOG2513 Protein required for meiotic chromosome segregation
Length = 946
Score = 389 bits (998), Expect = e-107
Identities = 275/896 (30%), Positives = 441/896 (48%), Gaps = 88/896 (9%)
Query: 2 SIFELDPNYVLVV-EYSKENLSVLLAELGAKGLLCECRPGHDAKNVYVFVR---DDLGNV 57
+I LDPN V+V + S N L E + PGHD + Y F+R D+ +
Sbjct: 4 TITSLDPNCVIVFNKTSSANEKSLNVEFKRLNIHSIIEPGHDLQTSYAFIRIHQDNAKPL 63
Query: 58 LKVVERFKFVTKVSPLY-TEGEREQMKRMAHELIRNRSLLTDNDLVQLAQVSGNPRVAMY 116
++ F+ + P + TE + K ++ + +L L+ ++ NP+ ++Y
Sbjct: 64 FSFLQNLDFIESIIPYHDTELSDDLHKLISISKSKILEAPKQYELYNLSNLTNNPKQSLY 123
Query: 117 FAFVKTYTRFLMPLAVFGLGLRLFNPSGMEFNAYYAVAVLIWAISFITLWKNKYEADYSS 176
FAF++ Y ++L+P + FGL +R + EFN+ Y++ ++W +SF W KYE +S
Sbjct: 124 FAFLQNYIKWLIPFSFFGLSIRFLSNFTYEFNSTYSLFAILWTLSFTAFWLYKYEPFWSD 183
Query: 177 -LFGYLSLIPLE-----------DSRITFMKKLCFFPIALLFVTLLVGFQLLCFALEIFL 224
L Y S +E S + +KK CF P+ALLF +L+ FQL CFALEIF
Sbjct: 184 RLSKYSSFSTIEFLQDKQKAQKKASSVIMLKKCCFIPVALLFGAILLSFQLYCFALEIFY 243
Query: 225 TQIYEGPLASVISLLPTVLLSVYVPILTLVYNKIFVDKMTAWENGT---NPERSKVEKNF 281
QIY GP+ S++S LPT+L+ + P+LT++YNK FV+ MT WEN + N ++SK KNF
Sbjct: 244 KQIYNGPMISILSFLPTILICTFTPVLTVIYNKYFVEPMTKWENHSSVVNAKKSKEAKNF 303
Query: 282 VFAFLTSYVPLLITLFIYFPFGHLLNAYL--PVIAKYSSLARIPVNTSAFKLNLARYQTQ 339
V FL+SYVPLLITLF+Y P GHLL A + V +S LAR+P + S F ++ RY+ Q
Sbjct: 304 VIIFLSSYVPLLITLFLYLPMGHLLTAEIRTKVFNAFSILARLPTHDSDFIIDTKRYEDQ 363
Query: 340 FFYFTVTNQVIALAMENVLPIVLGKIMPIVSGENKPNSDKSKVARLVAEQFPKEKAFLSN 399
FFYF V NQ+I +MEN +P ++ ++G N PN K++ A+ + S
Sbjct: 364 FFYFIVINQLIQFSMENFVPSLVSIAQQKINGPN-PNFVKAESEIGKAQLSSSDMKIWSK 422
Query: 400 VRDYNTGPWG-VFDVDDNMRKLVLQFGFVVLFSSIWPLAALICIIFNVVFIKLDLWRALV 458
V+ Y T PWG FD+D N +KL+LQFG++V+FS+IWPLA IC+I N++ ++DL +A++
Sbjct: 423 VKSYQTDPWGATFDLDANFKKLLLQFGYLVMFSTIWPLAPFICLIVNLIVYQVDLRKAVL 482
Query: 459 KSAPLVDTKARKDAVKE-DGYEDIKMTPWNSIITFLTWFSSLVTPALLLLYKYTNLPGSD 517
S P D + + + WNS++ + ++T L +Y+ N+PG
Sbjct: 483 YSKPEYFPFPIYDKPSSVSNTQKLTVGLWNSVLVMFSILGCVITATLTYMYQSCNIPGVG 542
Query: 518 SPASIQKRSISSTWYQYYPFHYDFKTVTLATFFLEHVFMFVYWVVSKILQSPLTKKSKTF 577
+ SI + WY P ++ + + L F+EHV + ++++ S IL+S +
Sbjct: 543 AHTSIH---TNKAWYLANPINHSWINIVLYAVFIEHVSVAIFFLFSSILKSSHDDVANGI 599
Query: 578 IPAXXXXXXXXXXXXHIVNNTVQFMSTLSNADCVTANGS-NEKTTAIKEPTEQQPKTAVT 636
+P ++ + + V GS NEK +E E+QP ++
Sbjct: 600 VPKHVVNVQNPPKQEVFEKIPSPEFNSNNEKELVQRKGSANEKLH--QELGEKQPASSAN 657
Query: 637 N-------------NAKSTGANITGEHDNKVKKRGPVSPVPLPVA----QPPTQTEAPLP 679
++ S+ ++ + + K G V V A + P TE+
Sbjct: 658 GYEAHAATHANNDPSSLSSASSPSLSSSSSSSKTGVVKAVDNDTAGSAGKKPLATES-TE 716
Query: 680 PKDVSNKVKTXXXXXXXXXVAGATLPPTIPTSKNF---------DLRNSTPNMEASSVAT 730
++ KV T VAGATLP TIPTSKN+ +R++ + E+S+
Sbjct: 717 KRNSLVKVPT----VGSYGVAGATLPETIPTSKNYYLRFDEDGKSIRDAKSSAESSNATN 772
Query: 731 LSSVPRANMKQED------LEQKIEANPSV-----KNKALPANQQSVSNKLPKVE----- 774
+++ + D L +KI+ P + +N + + K P ++
Sbjct: 773 NNTLGTESKLLPDGDAVDALSRKIDQIPKIAVTGGENNENTQAKDDAATKTPLIKDANIK 832
Query: 775 --INLAADAQQFVSSKAIEPEKQFVNENKIAATPQKQVT------SEMPAKSNKTT 822
+N A + Q S A E K+ E P + ++ S P+ +N TT
Sbjct: 833 PVVNAAVNDNQSKVSVATEQTKK--TEVSTKNGPSRSISTKETKDSARPSNNNTTT 886
>SPBP22H7.01c [D] KOG2513 Protein required for meiotic chromosome segregation
Length = 668
Score = 119 bits (299), Expect = 2e-26
Identities = 107/439 (24%), Positives = 191/439 (43%), Gaps = 62/439 (14%)
Query: 112 RVAMYFAFVKTYTRFLMPLAVFG-LGLRLFNPSGMEFNAYYAVAVLIWAISFITLWKNKY 170
+VA+YFAF + + L+ +G LG P ++ +A+ V +W FI W+ +
Sbjct: 177 QVALYFAFADFFKTGVFVLSFWGILGYYFLRP----YSYIFAIGVALWGAFFIQFWRVQ- 231
Query: 171 EADYSSLFGYLSLIPLEDSRITFMKK-------------------------LCFFPIALL 205
E ++ + ++ L S F + + P+ L+
Sbjct: 232 EHKLTNHWSTVNCQSLAKSMTEFKPQSYRVDSLLGTARPYYPQWEIIVRSTIANVPLFLI 291
Query: 206 FVTLLVGFQLLCFALEIFLTQIYEGPLASVISLLPTVLLSVYVPILTLVYNKIFVDKMTA 265
+L+ + F +++ L+++Y GPL S++SLLP V+ V T +Y+ I +++T
Sbjct: 292 SGCILLFLIAIAFIVDVTLSEVYSGPLKSIVSLLPAVVFQVLTLPFTFIYS-IVAERLTK 350
Query: 266 WEN---GTNPERSKVEKNFVFAFLTSYVPLLITLFIYFPFG-HLLNAYLPVIAKYSSLAR 321
EN T+ + S K F+ F+ SY L + +IY PF + + Y+ S +
Sbjct: 351 LENRRTKTDFQASLSGKMFLQNFMLSYTALFLISYIYGPFAEYFVPHYIQNRMSQSFFSV 410
Query: 322 IPVNTSAFKLNLARYQTQFFYFTVTNQVIALAMENVLPIVLGKIMPIVSGENKPNSDKSK 381
+ S FKLN R + Q+ YF QVI N + I+ +P + K +
Sbjct: 411 GYIAKSTFKLNPLRLRNQYIYFLTNAQVI-----NYITIL---AVPQLISYVKKHYMSKP 462
Query: 382 VARLVAEQFPKEKAFLSNVRDYNTGPWGVFDVDDNMRKLVLQFGFVVLFSSIWPLAALIC 441
L + P E L R + +D ++ + VL FGF+V+FS I+PLA +
Sbjct: 463 TRELHIQDIPSETVTLKRAR--SEAEKIEYDCYNDYKDFVLMFGFLVMFSPIYPLAPIFS 520
Query: 442 IIFNVVFIKLDLWR--ALVKSAPLVDTKARKDAVKEDGYEDIKMTPWNSIITFLTWFSSL 499
++ V++I+ ++R +VK R D++ PW+ ++ L+W +
Sbjct: 521 LVNCVLYIRSSVYRFTKMVKK----PVPCRVDSI----------APWDQRLSLLSWLGCI 566
Query: 500 VTPALLLLYKYTNLPGSDS 518
P++ Y T P S
Sbjct: 567 TMPSICYFYSSTTKPSDKS 585
>Hs8922384 [D] KOG2513 Protein required for meiotic chromosome segregation
Length = 589
Score = 79.3 bits (194), Expect = 2e-14
Identities = 87/370 (23%), Positives = 157/370 (41%), Gaps = 74/370 (20%)
Query: 113 VAMYFAFVKTYTRFLMPLAVFGLGLRLFNPSGMEFNAYYAVAVLIWAISFITLWKN---- 168
+A+YF F++ +T L+P+AV GL LF + +A LIW+ + LWK
Sbjct: 137 IALYFGFLEYFTFALIPMAVIGLPYYLFVWEDYDKYVIFASFNLIWSTVILELWKRGCAN 196
Query: 169 ------------KYEADYSSLFGYLSLIPL----EDSRITFMKKLCFFPIALLFVTLLVG 212
K+E G L + + E ++ ++L + ++L FV L +
Sbjct: 197 MTYRWGTLLMKRKFEEPRPGFHGVLGINSITGKEEPLYPSYKRQLRIYLVSLPFVCLCLY 256
Query: 213 FQL----LCFALEIFLTQIYEGP---LASVISLLPTVLLSVYVPILTLVYNKIFVDKMTA 265
F L + F +E++ ++E SV+ +P+++ ++ + I+ +Y + + +T+
Sbjct: 257 FSLYVMMIYFDMEVWALGLHENSGSEWTSVLLYVPSIIYAIVIEIMNRLY-RYAAEFLTS 315
Query: 266 WENG---TNPERSKVEKNFVFAFLTSYVPLLITLFIYFPFGHLLNAYLPVIAKYSSLARI 322
WEN + + + K VF FL + L Y+ + K L R
Sbjct: 316 WENHRLESAYQNHLILKVLVFNFLNCFASLF---------------YIAFVLKDMKLLRQ 360
Query: 323 PVNTSAFKLNLARYQTQFFYFTVTNQVIALAMENVLPIVLGKIMPIVSGENKPNSDKSKV 382
+ T +T+Q++ ME+ LP L + V + K + K+ +
Sbjct: 361 SLAT----------------LLITSQILNQIMESFLPYWLQRKHG-VRVKRKVQALKADI 403
Query: 383 ARLVAEQFPKEKAFLSNVRDYNTGPWGVFDVDDNMRKLVLQFGFVVLFSSIWPLAALICI 442
+ EQ EK + + G FD + +L LQFG+V LFS ++PLAA +
Sbjct: 404 DATLYEQVILEKEMGTYL--------GTFD---DYLELFLQFGYVSLFSCVYPLAAAFAV 452
Query: 443 IFNVVFIKLD 452
+ N + D
Sbjct: 453 LNNFTEVNSD 462
>Hs20480633 [S] KOG2514 Uncharacterized conserved protein
Length = 829
Score = 63.9 bits (154), Expect = 1e-09
Identities = 94/391 (24%), Positives = 151/391 (38%), Gaps = 55/391 (14%)
Query: 146 EFNAYYAVAVLIWAISFITLWKNK-----YE---ADYSSLFGYLSLIPLEDSRITFMKKL 197
E ++A+ + IW F+ WK + YE D+ L L P E + +KL
Sbjct: 322 ESTVFFAIFMGIWVTLFLEFWKQRQARLEYEWDLVDFEEEQQQLQLRP-EFEAMCKHRKL 380
Query: 198 CFFPIALLFVTLLVGFQLLCFALEIFLT----QIYEGPLASVISLL-PTVLLS------- 245
L VT +V ++ + L +F T + L V S L P + S
Sbjct: 381 NAVTKMSLVVTSMVA--VIVYRLSVFATFASFMESDASLKQVKSFLTPQITTSLTGSCLN 438
Query: 246 -VYVPILTLVYNKI--FVDKMTAWENGTNPERSKVEKNFVFAFLTSYVPLLITLFIYFPF 302
+ + IL Y KI ++ KM E S K F+F F+ Y F F
Sbjct: 439 FIVILILNFFYEKISAWITKMEIPRTYQEYESSLTLKMFLFQFVNFYSSCFYVAFFKGKF 498
Query: 303 GHLLNAYLPVIAKYSSLARIPVNTSAFKLNLARYQTQFFYFTVTNQVIALAMENVLPIVL 362
Y + ++ S P L TQ Q+ E + P+ L
Sbjct: 499 VGYPGKYTYLFNEWRSEECDPGGC------LIELTTQLTIIMTGKQIFGNIKEAIYPLAL 552
Query: 363 GKIMPIVSGENKPNSDKSKVARLVAEQFPKEKAFLSNVRDYNTGPWGVFDVDDNMRKLVL 422
N + + AR +E K + +D++ +G + + V
Sbjct: 553 -------------NWWRRRKARTNSE-----KLYSRWEQDHDLESFGPLGLFYEYLETVT 594
Query: 423 QFGFVVLFSSIWPLAALICIIFNVVFIKLDLWRALVKSAPLVDTKARKDAVKEDGYEDIK 482
QFGFV LF + +PLA L+ +I N+V I++D W+ + V +KA V +D +
Sbjct: 595 QFGFVTLFVASFPLAPLLALINNIVEIRVDAWKLTTQYRRTVASKAHSIGVWQDILYGMA 654
Query: 483 MTPWNSIIT--FLTWFSSLVTPALLLLYKYT 511
+ S+ T F+ F+S + P L+ Y Y+
Sbjct: 655 VL---SVATNAFIVAFTSDIIPRLVYYYAYS 682
>7300532 [S] KOG2514 Uncharacterized conserved protein
Length = 1075
Score = 61.6 bits (148), Expect = 5e-09
Identities = 94/428 (21%), Positives = 166/428 (37%), Gaps = 86/428 (20%)
Query: 141 NPSGMEFNAYYAVAVLIWAISFITLWKNKYEADYS---SLFGY--------------LSL 183
NPS ++AV + WA F+ LWK +Y A+ + L G+ L
Sbjct: 493 NPS----TVFFAVFMSFWATLFLELWK-RYSAEITHRWDLTGFDVHEEHPRPQYLARLEH 547
Query: 184 IP---------LEDSRITFMK----------KLCFFPIALLFVTLLVGFQLLCFALEIFL 224
IP +++ + F + + IAL FV LL ++ + + +
Sbjct: 548 IPPTRVDYVTNIKEPTVPFWRMKLPATVFSFSVVLLLIALAFVALLA---VVVYRMSMLA 604
Query: 225 T-QIYEGPLASVISLLPTVLLSVYVP-----ILTLVYNKI--FVDKMTAWENGTNPERSK 276
++ P+ + +++ + +V IL +YN + ++ ++ W T + S
Sbjct: 605 ALKVGASPMTTSSAIVLATASAAFVNLCLLYILNYMYNHLAEYLTELEMWRTQTQFDDSL 664
Query: 277 VEKNFVFAFLTSYVPLLITLFIYFPF-GHLLNAYLPVIAKYSSLARIPVNTSAFKLNLAR 335
K ++ F+ Y + F F GH +Y+ L + L
Sbjct: 665 TLKIYLLQFVNYYASIFYIAFFKGKFVGHP--------GEYNKLFDYRQEECSSGGCLTE 716
Query: 336 YQTQFFYFTVTNQVIALAMENVLPIVLGKIMPIVSG-----ENKPNSDKSKVARLVAEQF 390
Q V Q +E LP+ K++ I G N PN DK+K R +
Sbjct: 717 LCIQLAIIMVGKQAFNTILEVYLPMFWRKVLAIQVGLSRLFNNTPNPDKAKDERWM---- 772
Query: 391 PKEKAFLSNVRDYNTGPWGVFDVDDNMRKLVLQFGFVVLFSSIWPLAALICIIFNVVFIK 450
RD+ WG + ++VLQ+GFV +F + +PLA ++ N++ ++
Sbjct: 773 ----------RDFKLLDWGARGLFPEYLEMVLQYGFVTIFVAAFPLAPFFALLNNILEMR 822
Query: 451 LDLWRALVKSAPLVDTKARKDAVKEDGYEDIKMTPWNSIIT--FLTWFSSLVTPALLLLY 508
LD + L V + R V Y + S+IT F+ F+S + P L+ +
Sbjct: 823 LDAKKLLTHHKRPVSQRVRDIGV---WYRILDCIGKLSVITNGFIIAFTSDMIPRLVYRH 879
Query: 509 KYTNLPGS 516
Y N G+
Sbjct: 880 -YVNKQGT 886
>7292713 [S] KOG2514 Uncharacterized conserved protein
Length = 1058
Score = 57.8 bits (138), Expect = 7e-08
Identities = 108/502 (21%), Positives = 193/502 (37%), Gaps = 136/502 (27%)
Query: 112 RVAMYFAFVKTYTRFLMPLAVFGL-----GLRLFNP------------------------ 142
+VA+YFA++ YT+ L+P++VFG+ G +N
Sbjct: 431 KVALYFAWLGFYTQMLIPISVFGVLCFLYGFITWNSDPISRDICDDNGTIMCPQCDRSCD 490
Query: 143 --------SGMEFN--------AYYAVAVLIWAISFITLWKNKYEADYSSLFGYLSLI-- 184
+ +FN +A ++ IWA+ ++ WK +Y A +G
Sbjct: 491 YWRLNETCTSSKFNYLIDNNMTVVFAFSMAIWAVVYLEFWK-RYSAGLVHRWGLTGFTHH 549
Query: 185 -----PLEDSRITFMKKLC-------------------------FFP------IALLFVT 208
P +RI+ KKL F P I +LF+
Sbjct: 550 VEHPRPQYLARISRTKKLAGKAYEQDHTGKRTILDPDVPFWSFKFLPNFTSYSIMVLFIC 609
Query: 209 L-------LVGFQLLCFALEIFLTQIYEGPLASVISLLPT---VLLSVYVPILTLVYNKI 258
+ ++ +++ A L E + + +LP ++ + + +L +VY+ +
Sbjct: 610 ISVIAIAGIIIYRMAQRASHSILGS--ENSMTFKVMILPMTAGIIDLIVISLLDMVYSNL 667
Query: 259 FVDKMTAWE---NGTNPERSKVEKNFVFAFLTSYVPLLITLFIYFPFGHLLNAYLPVIAK 315
V K+T +E T + S KN+VF F+ Y L F L ++ AK
Sbjct: 668 AV-KLTNYEYCRTQTEYDESLTIKNYVFQFVNYYSSLFYIAF-------LKGKFVGYPAK 719
Query: 316 YSSLARIPVNTSAFKLNLARYQTQFFYFTVTNQVIALAMENVLPIVLG--KIMPIVSGEN 373
Y+ + L Q Q + +E ++P ++ K + G
Sbjct: 720 YNRVLGFRQEECNPGGCLMELCMQLVIIMAGKQAVNAIVEMLIPYLMRTFKELSYRHGWY 779
Query: 374 KPNSDKSKVARLVA-EQFPKEKAFLSNVRDYNTGPWGVFDVDDNMRKLVLQFGFVVLFSS 432
K + D+ RLV QF + DYN P + ++V+QFGF+ LFS
Sbjct: 780 KSHQDQ----RLVPYNQFTE---------DYNLLPAENNSLYVEYLEMVVQFGFITLFSL 826
Query: 433 IWPLAALICIIFNVVFIKLDLWRALVKSAPLVDTKARKDAVKEDGYEDIKMTPWNSIITF 492
+PLA L+ ++ NV+ ++LD + L V +AR V W+SI+T
Sbjct: 827 AFPLAPLLALLNNVIEVRLDAIKMLRFLRRPVGMRARDIGV------------WHSIMTV 874
Query: 493 LTWFSSLVTPALLLLYKYTNLP 514
+T ++ + A+++ + +P
Sbjct: 875 VTRI-AVASSAMIIAFSTNLIP 895
>Hs22062168 [S] KOG2514 Uncharacterized conserved protein
Length = 359
Score = 53.1 bits (126), Expect = 2e-06
Identities = 33/132 (25%), Positives = 69/132 (52%), Gaps = 5/132 (3%)
Query: 401 RDYNTGPWGVFDVDDNMRKLVLQFGFVVLFSSIWPLAALICIIFNVVFIKLDLWRALVKS 460
+DY+ P G + ++++QFGFV LF + +PLA L+ ++ N++ I++D W+ +
Sbjct: 100 QDYHLQPMGKLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQF 159
Query: 461 APLVDTKARKDAVKEDGYEDIKMTPWNSIIT--FLTWFSSLVTPALLLLYKYTNLPGSDS 518
LV KA+ + + I + +++T + F+S + P L+ + ++ P D
Sbjct: 160 RRLVPEKAQDIGAWQPIMQGIAIL---AVVTNAMIIAFTSDMIPRLVYYWSFSVPPYGDH 216
Query: 519 PASIQKRSISST 530
+ + I++T
Sbjct: 217 TSYTMEGYINNT 228
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.320 0.135 0.390
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 47,706,844
Number of Sequences: 60738
Number of extensions: 2020936
Number of successful extensions: 7518
Number of sequences better than 1.0e-05: 7
Number of HSP's better than 0.0 without gapping: 2
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 7491
Number of HSP's gapped (non-prelim): 15
length of query: 857
length of database: 30,389,216
effective HSP length: 115
effective length of query: 742
effective length of database: 23,404,346
effective search space: 17366024732
effective search space used: 17366024732
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)