ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactII3155 good O KOG2090 Posttranslational modification, protein turnover, chaperones Metalloendopeptidase family - mitochondrial intermediate peptidase
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactII3155 1086468 1084132 -779
(779 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YKL134c [O] KOG2090 Metalloendopeptidase family - mitochondrial ... 781 0.0
SPAC1F3.10c [O] KOG2090 Metalloendopeptidase family - mitochondr... 427 e-119
Hs20548472 [O] KOG2090 Metalloendopeptidase family - mitochondri... 324 3e-88
Hs5174567 [O] KOG2090 Metalloendopeptidase family - mitochondria... 320 5e-87
At5g51540 [O] KOG2090 Metalloendopeptidase family - mitochondria... 302 1e-81
7302217 [O] KOG2090 Metalloendopeptidase family - mitochondrial ... 295 2e-79
CE28378 [O] KOG2090 Metalloendopeptidase family - mitochondrial ... 236 1e-61
Hs4507491 [O] KOG2089 Metalloendopeptidase family - saccharolysi... 160 9e-39
YCL057w [O] KOG2089 Metalloendopeptidase family - saccharolysin ... 158 3e-38
Hs14149738 [O] KOG2089 Metalloendopeptidase family - saccharolys... 154 7e-37
At5g65620 [O] KOG2089 Metalloendopeptidase family - saccharolysi... 149 2e-35
At5g10540 [O] KOG2089 Metalloendopeptidase family - saccharolysi... 137 6e-32
At1g67700 [O] KOG2089 Metalloendopeptidase family - saccharolysi... 118 3e-26
7301239 [O] KOG2089 Metalloendopeptidase family - saccharolysin ... 89 2e-17
Hs20543391 [O] KOG2090 Metalloendopeptidase family - mitochondri... 78 6e-14
>YKL134c [O] KOG2090 Metalloendopeptidase family - mitochondrial
intermediate peptidase
Length = 770
Score = 781 bits (2017), Expect = 0.0
Identities = 390/736 (52%), Positives = 526/736 (70%), Gaps = 16/736 (2%)
Query: 40 LRRVFDDDSHWRALNHSNYKLNESKGRKFGLRSTSDLETGLFQNSYLKSANGLVEFTQHS 99
++++FDD+S+WR +N + N SK ++ + +TGLF+N YL S +GL +F+Q S
Sbjct: 42 IKKIFDDNSYWRNINGQD--ANNSKISQYLFKKN---KTGLFKNPYLTSPDGLRKFSQVS 96
Query: 100 FEKAKELVQKIHSIETQDEMKYYIKDLDQLSDVLCRVIDLCEFIRATHPDKKFVQTAQQC 159
++A+EL+ K+ + ++ YI +LD+LSD LCRVIDLCEFIR+THPD FV+ AQ C
Sbjct: 97 LQQAQELLDKMRNDFSESGKLTYIMNLDRLSDTLCRVIDLCEFIRSTHPDDAFVRAAQDC 156
Query: 160 HEKMFEIMNILNTDVRLCDLLTQCLRESDVLG-LDSEEIRTGKILLEDFEKSGIYMKPEI 218
HE+MFE MN+LNTDV LC++L L +V L +EE++ GKILL+DFEKSGIYM P++
Sbjct: 157 HEQMFEFMNVLNTDVSLCNILKSVLNNPEVSSKLSAEELKVGKILLDDFEKSGIYMNPDV 216
Query: 219 REKFIQLSQEISVIGQDFINNTEYVRSNYIKISCELMD-AHVNKMVCSQMKKDITGEYYK 277
REKFIQLSQEIS++GQ+FIN+T+Y SN +KI C+ +D + V+ + Q+ KD+ G+ YK
Sbjct: 217 REKFIQLSQEISLVGQEFINHTDYPGSNSVKIPCKDLDNSKVSTFLLKQLNKDVKGQNYK 276
Query: 278 VPTYGYIPHTLLRTCSDEVIRMKIWTEMHSCSDAQIERLTKLISLRVELAKLLGSQNFAQ 337
VPT+GY + LL++C +E++R K+WT +HSCSD Q++RL+ LI LR LA L+ ++A+
Sbjct: 277 VPTFGYAAYALLKSCENEMVRKKLWTALHSCSDKQVKRLSHLIKLRAILANLMHKTSYAE 336
Query: 338 YQLHGKMAKTPENVSGFLESLVHSTRIKAASELKPLAVLKSELTGTQTPHTSEEVLELMK 397
YQL GK F+ +L+++T K A+ELK +A LK++ ++E+L+L++
Sbjct: 337 YQLEGKWQD--RRCQDFILTLMNNTIEKTANELKFIAELKAKDLKKPLTTNTDEILKLVR 394
Query: 398 PWDRDYYGSIQALAQRRSSSLDNGESISSSFSLGVVMQGLSDLFEKIYGIKLVPATPKTG 457
PWDRDYY Q S+ N + IS F+LG V+QGLSDLF++IYGI+L PA G
Sbjct: 395 PWDRDYYTG--KYFQLNPSNSPNAKEISYYFTLGNVIQGLSDLFQQIYGIRLEPAITDEG 452
Query: 458 ETWSPDVRRIDVVDEHDGLIGVMYCDLFEREGKTPNPAHFTVCCSRNMYLNEADTSTIQV 517
ETWSPDVRR++V+ E +G+IG++YCDLFER GKT NPAHFTVCCSR +Y +E D STIQV
Sbjct: 453 ETWSPDVRRLNVISEEEGIIGIIYCDLFERNGKTSNPAHFTVCCSRQIYPSETDFSTIQV 512
Query: 518 GVNSNGQKFQLPVISLVCDFRWVEVNMGDGKHQQMCLLQLNEIETLFHEMGHAMHSMLGR 577
G N +G FQLPVISLVC+F + + + +C LQL+E+ETLFHEMGHAMHSMLGR
Sbjct: 513 GENPDGTYFQLPVISLVCNFSPILI----ASKKSLCFLQLSEVETLFHEMGHAMHSMLGR 568
Query: 578 TQLQNVSGTRCATDFVELPSILMEHFARDTRVLSSISSHYKTGKSLDVEVLKNHQLENQF 637
T +QN+SGTRCATDFVELPSILMEHFA+D R+L+ I HY TG+++ ++L+ F
Sbjct: 569 THMQNISGTRCATDFVELPSILMEHFAKDIRILTKIGKHYGTGETIQADMLQRFMKSTNF 628
Query: 638 LQNCETFSQIKMSFLDQELHNLDHTTD-GSIDVIAIYHRLERRLAVLPDDQSNWCGKFGH 696
LQNCET+SQ KM+ LDQ H+ +D + DV+ Y LERRL VL DDQSNWCG+FGH
Sbjct: 629 LQNCETYSQAKMAMLDQSFHDEKIISDIDNFDVVENYQALERRLKVLVDDQSNWCGRFGH 688
Query: 697 LFGYGASYYSYLFDRAIASKIWDHLFEQDPFNRTNGTKFKEGLLQWGGSRDPWYLLSQVL 756
LFG G + FDR IASKIW LFE DP++R NG KFK+ LL+WGG +DPW ++ VL
Sbjct: 689 LFGSGQLITATYFDRTIASKIWYALFEDDPYSRKNGDKFKKHLLKWGGLKDPWKCIADVL 748
Query: 757 DEPRLAKGDEWGMRYI 772
+ P L KG M +I
Sbjct: 749 ECPMLEKGGSDAMEFI 764
>SPAC1F3.10c [O] KOG2090 Metalloendopeptidase family - mitochondrial
intermediate peptidase
Length = 762
Score = 427 bits (1099), Expect = e-119
Identities = 270/772 (34%), Positives = 418/772 (53%), Gaps = 56/772 (7%)
Query: 19 CLIVNSVRHSSSATVNRLKQPLRRVFDDDSHWRALNHSNYKLNESKGRKFGLRSTSDLET 78
C++ ++S+ + Q LR++FDD N +N+ R G++
Sbjct: 20 CILSLYRKYSNVQSRKAEDQLLRQIFDDQ---------NIAVNQITKRN-GIQGV----- 64
Query: 79 GLFQNSYLKSAN-GLVEFTQHSFEKAKELVQKIHSIETQDEMKYYIKDLDQLSDVLCRVI 137
GLF+N +L + G + + + EK K +++ + +T+D + D++S++LC VI
Sbjct: 65 GLFRNHFLSDKDTGFLRLAETASEKCKAVIEDLLLEDTEDG-SIVVSKFDRISNLLCSVI 123
Query: 138 DLCEFIRATHPDKKFVQTAQQCHEKMFEIMNILNTDVRLCDLLTQCLRESDVL-GLDSEE 196
DL EF+R HPDK V A++ + +FE+MN LNT L + L L+++ L D E
Sbjct: 124 DLFEFVRCAHPDKMVVMKAEEAYSYLFELMNTLNTHQGLYEKLKCSLQQTPTLKDTDPEA 183
Query: 197 IRTGKILLEDFEKSGIYMKPEIREKFIQLSQEISVIGQDFINNTEYVRSNYIKISCELMD 256
G++ L+DFEKSG+ ++ R F++ S E + +G+ F NN+ Y+ IS + +
Sbjct: 184 YTVGRVFLQDFEKSGVNLESSKRNSFVKKSSESATLGRAFFNNSMNRPQRYLTISKQRLA 243
Query: 257 AHVNKMVCSQMKKDITGEYYKVPTYGYIPHTLLRTCSDEVIRMKIWTEMHSCSDAQIERL 316
V S K D + +PT GY L + ++ +R +I+ E H + ++E L
Sbjct: 244 GSDPYFVRSLSKND--KNFIMIPTVGYEGTQALISVANPDVRKEIYMEGHKGTVEEVELL 301
Query: 317 TKLISLRVELAKLLGSQNFAQYQLHGKMAKTPENVSGFLESLVHSTRIKAASELKPLAVL 376
+ + E+AKL+G +FA QL KMA P++V FLE+L LK +VL
Sbjct: 302 NSYLRSKAEVAKLVGKSSFADLQLIDKMANAPKHVVEFLENL----------SLKNSSVL 351
Query: 377 KSELTGTQTPHTSEEVLELMKP---WDRDYYGSI--QALAQRRSSSLDNGESISSSFSLG 431
K L E L + WDR+YY + Q+L ++ S + + FS+G
Sbjct: 352 KKILNNLALMKKKELNLNFLPSFDVWDREYYTARYKQSLINQKPSLNPSITNYRRFFSVG 411
Query: 432 VVMQGLSDLFEKIYGIKLVPATPKTGETWSPDVRRIDVVDEHDGLIGVMYCDLFEREGKT 491
V+QGLS LF +YG++ VPA GE W PDV +++V +E+D ++GV+Y DLF R GKT
Sbjct: 412 TVIQGLSRLFSSLYGLRFVPADISPGEVWHPDVNKVNVYNENDHVMGVIYFDLFARTGKT 471
Query: 492 PNPAHFTVCCSRNMYLNEADTSTIQVGVNS-------NGQKFQLPVISLVCDFRWVEVNM 544
AHFT+ SR + L D S I +G + + +++Q+PVISL+C+F
Sbjct: 472 DGAAHFTIRSSRELDLTSFDDS-ISLGFDDATNIRVKDNKRYQIPVISLLCNFV------ 524
Query: 545 GDGKHQQMCLLQLNEIETLFHEMGHAMHSMLGRTQLQNVSGTRCATDFVELPSILMEHFA 604
L L +++TLFHEMGHAMHS+LG T+ QN++GTRCATDFVELPSI+ME F
Sbjct: 525 -RSSGMDPTFLDLWDVKTLFHEMGHAMHSILGHTKYQNLAGTRCATDFVELPSIIMEFFM 583
Query: 605 RDTRVLSSISSHYKTGKSLDVEVLKNHQLENQFLQNCETFSQIKMSFLDQELHN---LDH 661
+ VL + + T L V+VL +H + + SQI M+ +DQ H+ LD
Sbjct: 584 SNPAVLPLYARYEGTEIPLPVQVLNHHNMVENSSAPLDLQSQICMAMVDQLFHSKVVLDP 643
Query: 662 TTDGSIDVIAIYHRLERRLAVLPDDQSNWCGKFGHLFGYGASYYSYLFDRAIASKIWDHL 721
+ + +V + + + P + W +F HL+GY A+YYSY+FD +AS I+ L
Sbjct: 644 SFNSIDEVTNVTRKFSGFESAPP---AAWYLQFSHLYGYSATYYSYIFDTVLASLIFSKL 700
Query: 722 FEQDPFNRTNGTKFKEGLLQWGGSRDPWYLLSQVLDEPRLAKGDEWGMRYIG 773
F +P +R G KF++ +L+WGGSR PW +++ L++P LA G E MR IG
Sbjct: 701 FAGNPLSREAGEKFRKAILRWGGSRSPWECVAEALEQPILATGGEEAMRRIG 752
>Hs20548472 [O] KOG2090 Metalloendopeptidase family - mitochondrial
intermediate peptidase
Length = 713
Score = 324 bits (831), Expect = 3e-88
Identities = 220/682 (32%), Positives = 337/682 (49%), Gaps = 61/682 (8%)
Query: 79 GLFQNSYLKSANGLVEFTQHSFEKAKELVQKIHSIETQDEMKYYIKDLDQLSDVLCRVID 138
GLF L + G + + K + LV + S + + D+LSD LCRV D
Sbjct: 64 GLFGVPELSAPEGFHIAQEKALRKTELLVDRACSTPPGPQT---VLIFDELSDSLCRVAD 120
Query: 139 LCEFIRATHPDKKFVQTAQQCHEKMFEIMNILNTDVRLCDLLTQCLRESDVL-GLDSEEI 197
L +F++ HP+ F + A++ + ++ LNT+V L L + L + ++ LD E
Sbjct: 121 LADFVKIAHPEPAFREAAEEACRSIGTMVEKLNTNVDLYQSLQKLLADKKLVDSLDPETR 180
Query: 198 RTGKILLEDFEKSGIYMKPEIREKFIQLSQEISVIGQDFINNTEYVRSNYIKISCELMDA 257
R ++ + DFE SGI++ E R++ + L+ +I + F+ T + KI L+
Sbjct: 181 RVAELFMFDFEISGIHLDKEKRKRAVDLNVKILDLSSTFLMGTNFPN----KIEKHLLPE 236
Query: 258 HVNKMVCSQMKKDITGEYYKVPTYGYIPHTLLRTCSDEVIRMKIWTEMHSCSDAQIERLT 317
H+ + S G++ I L D+++R + + Q++ L
Sbjct: 237 HIRRNFTS------AGDHI-------IIDGLHAESPDDLVREAAYKIFLYPNAGQLKCLE 283
Query: 318 KLISLRVELAKLLGSQNFAQYQLHGKMAKTPENVSGFLESLVHSTRIKAASELKPLAVLK 377
+L+S R LAKL+G F+ L G +AK PE V FLE L + + + + +K
Sbjct: 284 ELLSSRDLLAKLVGYSTFSHRALQGTIAKNPETVMQFLEKLSDKLSERTLKDFEMIRGMK 343
Query: 378 SELTGTQTPHTSEEVLELMKPWDRDYY-GSIQALAQRRSSSLDNGESISSSFSLGVVMQG 436
+L P S ++ PWD YY G I+A SL FSLG M+G
Sbjct: 344 MKLN----PQNS-----VIMPWDPPYYSGVIRAERYNIEPSL-----YCPFFSLGACMEG 389
Query: 437 LSDLFEKIYGIKLVPATPKTGETWSPDVRRIDVVDEHDGLIGVMYCDLFEREGKTPNPAH 496
L+ L ++ GI L P GE WS DVR++ VV E +GL+G +YCD F+R K H
Sbjct: 390 LNILLNRLLGISLYAEQPAKGEVWSEDVRKLAVVHESEGLLGYIYCDFFQRADKPHQDCH 449
Query: 497 FTVCCSRNMYLNEADTSTIQVGVNSNGQKFQLPVISLVCDFRWVEVNMGDGKHQQMCLLQ 556
FT+ R + +G +QLPV+ L+ +N+ LL
Sbjct: 450 FTIRGGR---------------LKEDGD-YQLPVVVLM-------LNLPRSSRSSPTLLT 486
Query: 557 LNEIETLFHEMGHAMHSMLGRTQLQNVSGTRCATDFVELPSILMEHFARDTRVLSSISSH 616
+ +E LFHEMGHAMHSMLGRT+ Q+V+GTRC TDF E+PSILME+FA D RV++ + H
Sbjct: 487 PSMMENLFHEMGHAMHSMLGRTRYQHVTGTRCPTDFAEVPSILMEYFANDYRVVNQFARH 546
Query: 617 YKTGKSLDVEVLKNHQLENQFLQNCETFSQIKMSFLDQELHNLDHTTDGSIDVIAIYHRL 676
Y+TG+ L ++ + + Q+ + LDQ H + + D++
Sbjct: 547 YQTGQPLPKNMVSRLCESKKVCAAADMQLQVFYATLDQIYHGKHPLRNSTTDILKETQEK 606
Query: 677 ERRLAVLPDDQSNWCGKFGHLFGYGASYYSYLFDRAIASKIWDHLFEQDPFNRTNGTKFK 736
L +P+ + W +F HL GYGA YYSYL RA+AS +W F QDPFNR G +++
Sbjct: 607 FYGLPYVPN--TAWQLRFSHLVGYGARYYSYLMSRAVASMVWKECFLQDPFNRAAGERYR 664
Query: 737 EGLLQWGGSRDPWYLLSQVLDE 758
+L GG R+P ++ +L +
Sbjct: 665 REMLAHGGGREPMLMVEGMLQK 686
>Hs5174567 [O] KOG2090 Metalloendopeptidase family - mitochondrial
intermediate peptidase
Length = 713
Score = 320 bits (820), Expect = 5e-87
Identities = 209/634 (32%), Positives = 320/634 (49%), Gaps = 58/634 (9%)
Query: 127 DQLSDVLCRVIDLCEFIRATHPDKKFVQTAQQCHEKMFEIMNILNTDVRLCDLLTQCLRE 186
D+LSD LCRV DL +F++ HP+ F + A++ + ++ LNT+V L L + L +
Sbjct: 109 DELSDSLCRVADLADFVKIAHPEPAFREAAEEACRSIGTMVEKLNTNVDLYQSLQKLLAD 168
Query: 187 SDVL-GLDSEEIRTGKILLEDFEKSGIYMKPEIREKFIQLSQEISVIGQDFINNTEYVRS 245
++ LD E R ++ + DFE SGI++ + R++ + L+ +I + F+ T +
Sbjct: 169 KKLVDSLDPETRRVAELFMFDFEISGIHLDKQKRKRAVDLNVKILDLSSTFLMGTNFPN- 227
Query: 246 NYIKISCELMDAHVNKMVCSQMKKDITGEYYKVPTYGYIPHTLLRTCSDEVIRMKIWTEM 305
KI L+ H+ + S G++ I L D+++R +
Sbjct: 228 ---KIEKHLLPEHIRRNFTS------AGDHI-------IIDGLHAESPDDLVREAAYKIF 271
Query: 306 HSCSDAQIERLTKLISLRVELAKLLGSQNFAQYQLHGKMAKTPENVSGFLESLVHSTRIK 365
+ Q++ L +L+S R LAKL+G F+ L G +AK PE V FLE L +
Sbjct: 272 LYPNAGQLKCLEELLSSRDLLAKLVGYSTFSHRALQGTIAKNPETVMQFLEKLSDKLSER 331
Query: 366 AASELKPLAVLKSELTGTQTPHTSEEVLELMKPWDRDYY-GSIQALAQRRSSSLDNGESI 424
+ + + +K +L + E+M PWD YY G I+A SL
Sbjct: 332 TLKDFEMIRGMKMKLNAQNS--------EVM-PWDPPYYSGVIRAERYNIEPSL-----Y 377
Query: 425 SSSFSLGVVMQGLSDLFEKIYGIKLVPATPKTGETWSPDVRRIDVVDEHDGLIGVMYCDL 484
FSLG M+GL+ L ++ GI L P GE WS DVR++ VV E +GL+G +YCD
Sbjct: 378 CPFFSLGACMEGLNILLNRLLGISLYAEQPAKGEVWSEDVRKLAVVHESEGLLGYIYCDF 437
Query: 485 FEREGKTPNPAHFTVCCSRNMYLNEADTSTIQVGVNSNGQKFQLPVISLVCDFRWVEVNM 544
F+R K HFT+ R + +G +QLP++ L+ +N+
Sbjct: 438 FQRADKPHQDCHFTIRGGR---------------LKEDGD-YQLPLVVLM-------LNL 474
Query: 545 GDGKHQQMCLLQLNEIETLFHEMGHAMHSMLGRTQLQNVSGTRCATDFVELPSILMEHFA 604
LL +E LFHEMGHAMHSMLGRT+ Q+V+GTRC TDF E+PSILME+FA
Sbjct: 475 PRSSRSSPTLLTPGMMENLFHEMGHAMHSMLGRTRYQHVTGTRCPTDFAEVPSILMEYFA 534
Query: 605 RDTRVLSSISSHYKTGKSLDVEVLKNHQLENQFLQNCETFSQIKMSFLDQELHNLDHTTD 664
D RV++ + HY+TG+ L ++ + + Q+ + LDQ H +
Sbjct: 535 NDYRVVNQFARHYQTGQPLPKNMVSRLCESKKVCAAADMQLQVFYATLDQIYHGKHPLRN 594
Query: 665 GSIDVIAIYHRLERRLAVLPDDQSNWCGKFGHLFGYGASYYSYLFDRAIASKIWDHLFEQ 724
+ D++ L +P+ + W +F HL GYGA YYSYL RA+AS +W F Q
Sbjct: 595 STTDILKETQEKFYGLPYVPN--TAWQLRFSHLVGYGARYYSYLMSRAVASMVWKECFLQ 652
Query: 725 DPFNRTNGTKFKEGLLQWGGSRDPWYLLSQVLDE 758
DPFNR G +++ +L GG R+P ++ +L +
Sbjct: 653 DPFNRAAGERYRREMLAHGGGREPMLMVEGMLQK 686
>At5g51540 [O] KOG2090 Metalloendopeptidase family - mitochondrial
intermediate peptidase
Length = 860
Score = 302 bits (774), Expect = 1e-81
Identities = 208/696 (29%), Positives = 349/696 (49%), Gaps = 64/696 (9%)
Query: 78 TGLFQNSYLKSANGLVEFTQHSFEKAKELVQKIHSIETQDEMKYYIKDLDQLSDVLCRVI 137
TGL+ +LK+A G F + E++ ELV I + + E+ IK +D++SD +C V+
Sbjct: 31 TGLYGFDHLKTAKGFQRFVADAIERSGELVSYISGMPSSPEI---IKAMDEISDTVCCVV 87
Query: 138 DLCEFIRATHPDKKFVQTAQQCHEKMFEIMNILNTDVRLCDLLTQCLRESDVLGLDSEEI 197
D E R THPD++FV+ A + +M + ++ LNT+ L + + ++S++ L E
Sbjct: 88 DSAELCRQTHPDREFVEEANKAAIEMNDYLHHLNTNHTLYAAVKKAEQDSNL--LTKEAS 145
Query: 198 RTGKILLEDFEKSGIYMKPEIREKFIQLSQEISVIGQDFINNTEYVRSNYIKISCELMDA 257
RT L DFE+ GI++ PE +K L+ I + ++F N + +
Sbjct: 146 RTAHHLRMDFERGGIHLDPEKLDKVNNLTTNIFQLCREFSENIADDPGHVDIFPGSRIPR 205
Query: 258 HVNKMV------CSQMKKDITGEYYKVPTYGYIPHT-------LLRTCSDEVIRMKIWTE 304
H++ ++ S + T +K G+ +T +L+ SDE +R ++ +
Sbjct: 206 HLHHLLNPTYRSTSGGSRGSTRSAHKSKQKGFRINTDPRTVSSILQWTSDEEVRKMVYIQ 265
Query: 305 MHSCSDAQIERLTKLISLRVELAKLLGSQNFAQYQLHGKMAKTPENVSGFLESLVHSTRI 364
+S A L KLI+ R EL++++G ++A + +AK+P+ V+ FL+ L + +
Sbjct: 266 GNSVPHANHGVLEKLIAARHELSQMMGCNSYADIMVEPNLAKSPKVVTSFLQELSKTVKP 325
Query: 365 KAASELKPLAVLKSELTGTQTPHTSEEVLELMKPWDRDYYGSIQALAQRRSSSLDNGES- 423
KA E + K E G + ++PWD YY S+ SS+++ ++
Sbjct: 326 KADEEFIAIRDFKREKCGNPSAE--------LEPWDETYYTSMM------KSSINDVDTA 371
Query: 424 -ISSSFSLGVVMQGLSDLFEKIYG--IKLVPATPKTGETWSPDVRRIDVVDEHDGLIGVM 480
++S F L ++GL L E ++G +P P GE+W P+V ++ + +G +G +
Sbjct: 372 VVASYFPLPQCIEGLKVLVESLFGATFHTIPLAP--GESWHPNVVKLSLHHPDEGDLGYL 429
Query: 481 YCDLFEREGKTPNPAHFTVCCSRNMYLNEADTSTIQVGVNSNGQKFQLPVISLVCDFRWV 540
Y DL+ R+GK P A F + R + E +QLPVI+LVC+F
Sbjct: 430 YLDLYSRKGKYPGCASFAIRGGRKISETE----------------YQLPVIALVCNF--- 470
Query: 541 EVNMGDGKHQQMCLLQLNEIETLFHEMGHAMHSMLGRTQLQNVSGTRCATDFVELPSILM 600
+ L +E+E LFHE GHA+HS+L RT Q+ SGTR A D E+PS L
Sbjct: 471 ----SRACDSSIVKLNHSEVEVLFHEFGHALHSLLSRTDYQHFSGTRVALDLAEMPSNLF 526
Query: 601 EHFARDTRVLSSISSHYKTGKSLDVEVLKNHQLENQFLQNCETFSQIKMSFLDQELHNLD 660
E++A D R+L + HY TG+++ +++ + Q E Q+ + +DQ L
Sbjct: 527 EYYAWDYRLLKRFARHYSTGETIPEKLVNSLQGARNMFAATEMQRQVFYALIDQMLFGEQ 586
Query: 661 HTTDGSIDVIAIYHRLERRLAVLPD-DQSNWCGKFGHLFGYGASYYSYLFDRAIASKIWD 719
T + DV + L+R+ + ++W +F HL YGA YYSYL+ + AS IW
Sbjct: 587 PET--ARDVSHLVAELKRQHTSWNHVEGTHWYIRFSHLLNYGAGYYSYLYAKCFASTIWQ 644
Query: 720 HLFEQDPFNRTNGTKFKEGLLQWGGSRDPWYLLSQV 755
+ E+DP + GT +E + GG++DP LL+ +
Sbjct: 645 SICEEDPLSLNTGTLLREKFFKHGGAKDPAELLTDL 680
>7302217 [O] KOG2090 Metalloendopeptidase family - mitochondrial
intermediate peptidase
Length = 699
Score = 295 bits (755), Expect = 2e-79
Identities = 202/669 (30%), Positives = 314/669 (46%), Gaps = 56/669 (8%)
Query: 77 ETGLFQNSYLKSANGLVEFTQHSFEKAKELVQKIHSIETQDEMKYYIKDLDQLSDVLCRV 136
+ GLF L+S G + + +EL+ + S + + +M + D+LSD LC+V
Sbjct: 44 DVGLFGMPELRSFEGFYLLRDNVESRTQELISEATSDQRRRKM---VDIFDELSDSLCKV 100
Query: 137 IDLCEFIRATHPDKKFVQTAQQCHEKMFEIMNILNTDVRLCDLLTQCLRESDVLGLDSEE 196
DL EF+R HP ++ Q A+Q + ++ LNT + L+ + D L +
Sbjct: 101 ADLAEFVRIAHPQSRYTQAAEQACISICGMVESLNTHKPIYKALSHVVDHGDKLPTSEVD 160
Query: 197 IRTGKILLEDFEKSGIYMKPEIREKFIQLSQEISVIGQDFINNTEYVRSNYIKISCELMD 256
++ L DFE+ GI++ E R + ++L+ I +GQ F++ V+ + + S ++ +
Sbjct: 161 RHVSRLFLFDFEQCGIHLPEEERMRVVRLNDYILQLGQKFMSGA--VQPSVLPRS-QVPE 217
Query: 257 AHVNKMVCSQMKKDITGEYYKVPTYGYIPHTLLRTCSDEVIRMKIWTEMHSCSDAQIERL 316
+ N S ITG L + +R + S +Q + L
Sbjct: 218 SFRNYFPTSGENVIITG--------------LCTNAENVQMREAAYRLYLQPSKSQEDLL 263
Query: 317 TKLISLRVELAKLLGSQNFAQYQLHGKMAKTPENVSGFLESLVHSTRIKAASELKPLAVL 376
L+ R ELA+ G +A L G + PE V F++ L R +A + ++ +
Sbjct: 264 RDLLLCRHELARSCGFDTYAHRALKGSTMEKPEVVREFIDELSEKLRPRADCDFALMSQM 323
Query: 377 KSELTGTQTPHTSEEVLELMKPWDRDYYGSIQALAQRRSSSLDNGESISSSFSLGVVMQG 436
K G + WD YY + RR ++ FSLG M+G
Sbjct: 324 KRREGGKADARA--------EVWDTPYYTN----QLRRQLFEEHANEFLPYFSLGGCMEG 371
Query: 437 LSDLFEKIYGIKLVPATPKTGETWSPDVRRIDVVDEHDGLIGVMYCDLFEREGKTPNPAH 496
L +L +YGI+L K GE W D+ ++ VV E +GL+G +YCD +ER GK H
Sbjct: 372 LDNLLHALYGIRLQNTDLKPGEAWHNDIYKLAVVHEREGLLGYIYCDFYERVGKPNQDCH 431
Query: 497 FTVCCSRNMYLNEADTSTIQVGVNSNGQKFQLPVISLVCDFRWVEVNMGDGKHQQMCLLQ 556
FT IQ G +QLPV+ ++ + + + LL
Sbjct: 432 FT----------------IQGGKRMPDGSYQLPVVVVM-------LGLAQPRWSGPTLLS 468
Query: 557 LNEIETLFHEMGHAMHSMLGRTQLQNVSGTRCATDFVELPSILMEHFARDTRVLSSISSH 616
++ LFHEMGHAMHSML RT+ Q+V+GTRC+TDF E+PS+LME+FA D RVL + + H
Sbjct: 469 PARLDNLFHEMGHAMHSMLARTEHQHVTGTRCSTDFAEVPSVLMEYFAGDPRVLRTFARH 528
Query: 617 YKTGKSLDVEVLKNHQLENQFLQNCETFSQIKMSFLDQELHNLDHTTDGSIDVIAIYHRL 676
++T + + ++L+ ET Q+ S LDQE H G +
Sbjct: 529 FQTHEPISEDMLRRLCASKNLFAASETQLQVFYSALDQEYHGAS-ARHGQSSTDTLRSVQ 587
Query: 677 ERRLAVLPDDQSNWCGKFGHLFGYGASYYSYLFDRAIASKIWDHLFEQDPFNRTNGTKFK 736
+ + D + W +F HL GYGA YY+YL + IAS IW FE +PFNR G K++
Sbjct: 588 DHYYGLPYVDNTAWQLRFSHLVGYGAKYYAYLVSKTIASWIWQTYFEANPFNRQAGEKYR 647
Query: 737 EGLLQWGGS 745
+L GG+
Sbjct: 648 AEILAHGGA 656
>CE28378 [O] KOG2090 Metalloendopeptidase family - mitochondrial
intermediate peptidase
Length = 784
Score = 236 bits (601), Expect = 1e-61
Identities = 203/762 (26%), Positives = 327/762 (42%), Gaps = 114/762 (14%)
Query: 75 DLETGLFQNSYLKSANGLVEFTQHSFEKAKELVQKIHSIETQDEMKYYIKDLDQLSDVLC 134
D ETGLF N LK+A E + L+Q++ + + I+ +D +S+ +C
Sbjct: 29 DKETGLFGNKNLKTAESFNELPAAVKKSTDALIQEL--LTPSQNPRTSIQIVDDISNEIC 86
Query: 135 RVIDLCEFIRATHPDKKFVQTAQQCHEKMFEIMNILNTDVRLCDLLTQCLRESDVLG--- 191
+ DL E +R H + +F A+ E++ LNT+ L Q L+ S++
Sbjct: 87 KSADLAECVRQLHSEPEFRNAAEDVSRNFCELVESLNTNTALY----QKLKSSEITESSR 142
Query: 192 LDSEEIRTGKILLEDFEKSGIYMKPEIREKFIQLSQEISVIGQDFINNTEYVRS--NYIK 249
LD + RT +LL+DFE+SG+++K +E+F+QLS EI G F N + + S N+
Sbjct: 143 LDDVDKRTLTLLLDDFEQSGVHLKDNQKEQFVQLSSEIFDAGARFQQNCDRIVSVGNFSA 202
Query: 250 ISCELMDAHVNKMVCSQMKKDITGEYYKVPT----------------YGYIPHTLLRTCS 293
I D NKM+ + + + +K P YG +P + S
Sbjct: 203 IFIHFSD---NKMLNCHERIYFSKKNFKTPQKWMKIAEKLKKFDQAKYG-LPSQIYTPVS 258
Query: 294 DEVIRMK---IWTEMHSCSDAQIERLTKLISLRVELAKLLGSQNFAQYQLHGKMAKTPEN 350
+ + R K ++ + D Q L LIS R +L++L G ++FA + + +
Sbjct: 259 NSLDRSKRKMVYNTFYRHDDIQESYLQHLISSRHQLSQLTGFESFAHRAQRNSLLENYDT 318
Query: 351 VSGFLESLVHSTRIKAASELKPLAVLKSELTGTQTPHTSEEV-------LELMKPWDRDY 403
V FL +V R EL L + ++ + + + E+ L + R Y
Sbjct: 319 VRSFLWGVVEKCRGAFEKELAVLIDVSAQCSQQDNNNGNNEISTIAEHDLGFLMHLYRVY 378
Query: 404 Y----------------------------------------GSIQALAQRRSSSLDNGES 423
Y G I+ +++ +
Sbjct: 379 YTHPTRKYSSMSRRDWNIFVHCAFEGYCSNFELRGNINVKNGKIKRISESAYDIAQVSQQ 438
Query: 424 ISSSFSLGVVMQGLSDLFEKIYGIKLVPATPKTGETW-SPDVRRIDVVDEHDGLIGVMYC 482
S F+ + G S L +++YG++L+ +GE W S V ++ VDE + +GV+Y
Sbjct: 439 SSPFFTFNSIWNGFSTLTQRLYGVRLIEEPLISGEMWNSSGVMKLQAVDEQNNELGVIYV 498
Query: 483 DLFEREGKTPNPAHFTVCCSRNMYLNEADTSTIQVGVNSNGQKFQLPVISLVCDFRWVEV 542
D+ R K H+TV CS+ + S+G +Q+P++ L +
Sbjct: 499 DVSIRPEKAVGDCHYTVRCSKQL---------------SDGT-WQMPILVL-------SL 535
Query: 543 NMGDGKHQQM--CLLQLNEIETLFHEMGHAMHSMLGRTQLQNVSGTRCATDFVELPSILM 600
+ DG Q + + ET+FHE+GHAMHS+LGRT+ Q+V+GTRC DF E+PS LM
Sbjct: 536 GLVDGHSSQWRNSRVSFHSAETMFHELGHAMHSILGRTKYQHVAGTRCPQDFSEIPSNLM 595
Query: 601 EHFARDTRVLSSISSHY-KTGKSLDVEVLKNHQLENQFLQNCETFSQIKMSFLDQELHN- 658
E+F D V++ I + + L +E ET Q D E+H
Sbjct: 596 EYFFSDLGVMTDIIRRTDRPEEQLSIESAATLLASRHSFTAIETVQQAAYGLYDLEVHGP 655
Query: 659 --LDHTTDGSIDVIAIYHRLERRLA--VLPDDQSNWCGKFGHLFGYGASYYSYLFDRAIA 714
G + ++H + + + S + +F H YGA YYSYL RA A
Sbjct: 656 IAAPQIASGRMTTTELFHDIMNKTMPHIQRSPDSAFQHRFHHTVQYGAKYYSYLVARASA 715
Query: 715 SKIWDHLFEQDPFNRTNGTKFKEGLLQWGGSRDPWYLLSQVL 756
IW F DPF+R G + E + GG P LL ++L
Sbjct: 716 CLIWQQRFLNDPFSRKWGDCWAE-VQSHGGGHHPAVLLEKIL 756
>Hs4507491 [O] KOG2089 Metalloendopeptidase family - saccharolysin & thimet
oligopeptidase
Length = 689
Score = 160 bits (404), Expect = 9e-39
Identities = 168/681 (24%), Positives = 293/681 (42%), Gaps = 59/681 (8%)
Query: 88 SANGLVEFTQHSFEKAKELVQKIHSIETQDEMKYYIKDLDQLSDVLCRVI---DLCEFIR 144
SA + E T+ E+ K + ++ + E +D Y L L+DV ++ +F +
Sbjct: 29 SAQQIEERTRELIEQTKRVYDQVGTQEFEDVS--YESTLKALADVEVTYTVQRNILDFPQ 86
Query: 145 ATHPDKKFVQTAQQCHEKM--FEIMNILNTDV--RLCDLLTQCLRESDVLGLDSEEIRTG 200
P K + + +K+ F++ + DV R+ L + ++S L E R
Sbjct: 87 HVSPSKDIRTASTEADKKLSEFDVEMSMREDVYQRIVWLQEKVQKDS----LRPEAARYL 142
Query: 201 KILLEDFEKSGIYMKPEIREKFIQLSQEISVIGQDFINNTEYVRSNYIKISCELMDAHVN 260
+ L++ ++G+++ E +E ++ +++S++ DF N + ++ + + +
Sbjct: 143 ERLIKLGRRNGLHLPRETQENIKRIKKKLSLLCIDFNKNLNE-DTTFLPFTLQELGGLPE 201
Query: 261 KMVCSQMKKDITGEYYKVPTYGYIPHTLLRTCSDEVIRMKIWTEMHS-CSDAQIERLTKL 319
+ S K + + Y P LL+ C R K+ + C + L +L
Sbjct: 202 DFLNSLEKMEDGKLKVTLKYPHYFP--LLKKCHVPETRRKVEEAFNCRCKEENCAILKEL 259
Query: 320 ISLRVELAKLLGSQNFAQYQLHGKMAKTPENVSGFLESLVHSTRIKAASELKPLAVLKSE 379
++LR + ++LLG A Y L MAKT + V+ FL+ L ++K E + +L E
Sbjct: 260 VTLRAQKSRLLGFHTHADYVLEMNMAKTSQTVATFLDELAQ--KLKPLGEQERAVIL--E 315
Query: 380 LTGTQTPHTSEEVLELMKPWDRDYYGSIQALAQRRSSSLDNGESISSSFSLGVVMQGLSD 439
L + ++ WD YY + + + R N + F + VV GL
Sbjct: 316 LKRAECERRGLPFDGRIRAWDMRYY--MNQVEETRYCVDQN--LLKEYFPVQVVTHGLLG 371
Query: 440 LFEKIYGIKLVPATPKTGETWSPDVRRIDVVDEHDG-LIGVMYCDLFEREGKTPNPAHFT 498
+++++ G+ + W DVR D G ++G Y DL+ REGK + A F
Sbjct: 372 IYQELLGLAF--HHEEGASAWHEDVRLYTARDAASGEVVGKFYLDLYPREGKYGHAACFG 429
Query: 499 VCCSRNMYLNEADTSTIQVGVNSNGQKFQLPVISLVCDFRWVEVNMGDGKHQQMCLLQLN 558
+Q G Q+ + ++V +F + LLQ +
Sbjct: 430 ----------------LQPGCLRQDGSRQIAIAAMVANFTKPTADAPS-------LLQHD 466
Query: 559 EIETLFHEMGHAMHSMLGRTQLQNVSGTRCATDFVELPSILMEHFARDTRVLSSISSHYK 618
E+ET FHE GH MH + + + SGT DFVE PS ++E++ + L +S HY+
Sbjct: 467 EVETYFHEFGHVMHQLCSQAEFAMFSGTHVERDFVEAPSQMLENWVWEQEPLLRMSRHYR 526
Query: 619 TGKSLDVEVLKNHQLENQFLQNCETFSQIKMSFLDQELHNLDHTTDGSIDVIAIYHRL-E 677
TG ++ E+L+ Q QI ++ +DQ LH T D Y RL +
Sbjct: 527 TGSAVPRELLEKLIESRQANTGLFNLRQIVLAKVDQALH-----TQTDADPAEEYARLCQ 581
Query: 678 RRLAVLPDDQSNWCGKFGHLF-GYGASYYSYLFDRAIASKIWDHLFEQD-PFNRTNGTKF 735
L V +N FGHL GY A YY YL+ + ++ F+Q+ N G +
Sbjct: 582 EILGVPATPGTNMPATFGHLAGGYDAQYYGYLWSEVYSMDMFHTRFKQEGVLNSKVGMDY 641
Query: 736 KEGLLQWGGSRDPWYLLSQVL 756
+ +L+ GGS D +L + L
Sbjct: 642 RSCILRPGGSEDASAMLRRFL 662
>YCL057w [O] KOG2089 Metalloendopeptidase family - saccharolysin & thimet
oligopeptidase
Length = 712
Score = 158 bits (400), Expect = 3e-38
Identities = 163/648 (25%), Positives = 287/648 (44%), Gaps = 62/648 (9%)
Query: 122 YIKDLDQLSDVLCRVIDLCEFIRATHPDKKFVQTAQQCHEKMFEIMNILNTDVRLC-DLL 180
+++ + + L +I+ F++ DK+ + K+ E LN D+ L D+
Sbjct: 79 FVEPFMKFENELGPIINQLTFLQHVSSDKEIRDASVNSSMKLDE----LNIDLSLRHDIF 134
Query: 181 TQCLRE-SDVLG-LDSEEIRTGKIL---LEDFEKSGIYMKPEIREKFIQLSQEISVIGQD 235
Q R DV DS E T K + +D+ SG+ + R K ++ ++ISV +
Sbjct: 135 LQFARVWQDVQSKADSVERETFKYVEKSYKDYIHSGLELDEGNRLKIKEIKKKISVNSIN 194
Query: 236 FINNTEYVRSNYIKISCELM----DAHVNKMVCSQMKKDITGEYYKVPTYGYIP-HTLLR 290
F N + YI + E + D+ + + + KD YKV T+ Y +++
Sbjct: 195 FSKNLGE-QKEYITFTKEQLEGVPDSILTQFETIKSDKDSNETLYKV-TFKYPDIFPVMK 252
Query: 291 TCSDEVIRMKIWTEMHSCSDAQIERLTKLISLRVELAKLLGSQNFAQYQLHGKMAKTPEN 350
S R + + + L + LR ELA LLG +A Y L+ KMA+
Sbjct: 253 LASSAQTRKQAFLADQNKVPENEAILLDTLKLRDELASLLGYDTYANYNLYDKMAEDSTT 312
Query: 351 VSGFLESLVHSTRIKAASELKPLAVLKSELTGTQTPHTSEEVLELMKPWDRDYYGSIQAL 410
V FL L EL+ L +K+E ++ WD YY + + L
Sbjct: 313 VMNFLNDLKDKLIPLGRKELQVLQDMKAE----DVKKLNQGADPNYYIWDHRYYDN-KYL 367
Query: 411 AQRRSSSLDNGESISSSFSLGVVMQGLSDLFEKIYGIKLVPATPKTGET-WSPDVRRIDV 469
+ + L E IS F L + G+ +++E ++ +K + ++ W DV++I V
Sbjct: 368 LENFNVDL---EKISEYFPLEATITGMLEIYETLFNLKFIETKDSQNKSVWHDDVKQIAV 424
Query: 470 VDEHD----GLIGVMYCDLFEREGKTPNPAHFTVCCSRNMYLNEADTSTIQVGVNSNGQK 525
+ D +G +Y DL R+GK + A+F + S + +++ S
Sbjct: 425 WNMDDPKSPNFVGWIYFDLHPRDGKYGHAANFGL--SSSFMIDDTTRS------------ 470
Query: 526 FQLPVISLVCDFRWVEVNMGDGKHQQMCLLQLNEIETLFHEMGHAMHSMLGRTQLQNVSG 585
PV +LVC+F + LL+ NEI T FHE+GH +H ++G+ + +G
Sbjct: 471 --YPVTALVCNF-------SKSTKDKPSLLKHNEIVTFFHELGHGIHDLVGQNKESRFNG 521
Query: 586 TRCAT-DFVELPSILMEHFARDTRVLSSISSHYKTGKSLDVEVLKNHQLENQFLQNC-ET 643
DFVE PS ++E + + L ++SSHYKTG+ + E L N ++ + + T
Sbjct: 522 PGSVPWDFVEAPSQMLEFWTWNKNELINLSSHYKTGEKIP-ESLINSLIKTKHVNGALFT 580
Query: 644 FSQIKMSFLDQELHNLDHTTDGSIDVIAIYHRLERRLAVLPD--DQSNWCGKFGHLF--G 699
Q+ D ++H ++ + +++L + ++++ + S FGH+
Sbjct: 581 LRQLHFGLFDMKVHTCKDLQ--NLSICDTWNQLRQDISLISNGGTLSKGYDSFGHIMSDS 638
Query: 700 YGASYYSYLFDRAIASKIWDHLFEQDPFNRTNGTKFKEGLLQWGGSRD 747
Y A YY YL+ A+ ++ F +DP N NG ++++ +L GG D
Sbjct: 639 YSAGYYGYLWAEVFATDMYHTKFAKDPLNAKNGIQYRDIVLARGGLYD 686
>Hs14149738 [O] KOG2089 Metalloendopeptidase family - saccharolysin & thimet
oligopeptidase
Length = 704
Score = 154 bits (388), Expect = 7e-37
Identities = 162/651 (24%), Positives = 274/651 (41%), Gaps = 65/651 (9%)
Query: 122 YIKDLDQLSDVLCRVI---DLCEFIRATHPDKKFVQTAQQCHEKM--FEIMNILNTDV-- 174
Y L L+DV + I + +F + DK+ + + +++ F+I + D+
Sbjct: 85 YENCLQALADVEVKYIVERTMLDFPQHVSSDKEVRAASTEADKRLSRFDIEMSMRGDIFE 144
Query: 175 RLCDLLTQCLRESDVLGLDSEEIRTGKILLEDFEKSGIYMKPEIREKFIQLSQEISVIGQ 234
R+ L C D+ + E R + ++ +++G+++ +++ + + + +S +
Sbjct: 145 RIVHLQETC----DLGKIKPEARRYLEKSIKMGKRNGLHLPEQVQNEIKSMKKRMSELCI 200
Query: 235 DFINNTEYVRSNYIKISCELMDAHVNKMVCSQMKKDITGEYYKVPT-YGYIPHTLLRTCS 293
DF N ++ S + A + + S K D + YK+ Y + + + C
Sbjct: 201 DFNKNLNE-DDTFLVFSKAELGALPDDFIDSLEKTD--DDKYKITLKYPHYFPVMKKCCI 257
Query: 294 DEVIRMKIWTEMHSCSDAQIERLTKLISLRVELAKLLGSQNFAQYQLHGKMAKTPENVSG 353
E R C + L +L+ LR ++AKLLG A + L AK+ V+
Sbjct: 258 PETRRRMEMAFNTRCKEENTIILQQLLPLRTKVAKLLGYSTHADFVLEMNTAKSTSRVTA 317
Query: 354 FLESLVHSTRIKAASELKPLAVLKSE----LTGTQTPHTSEEVLELMKPWDRDYYGSIQA 409
FL+ L + +LKPL + E L + E + WD YY
Sbjct: 318 FLDDL--------SQKLKPLGEAEREFILNLKKKECKDRGFEYDGKINAWDLYYY---MT 366
Query: 410 LAQRRSSSLDNGESISSSFSLGVVMQGLSDLFEKIYGIKLVPATPKTGETWSPDVRRIDV 469
+ S+D E + F + VV +GL + ++++ G+ T W+ V V
Sbjct: 367 QTEELKYSIDQ-EFLKEYFPIEVVTEGLLNTYQELLGLSFEQMTD--AHVWNKSVTLYTV 423
Query: 470 VDEHDG-LIGVMYCDLFEREGKTPNPAHFTVCCSRNMYLNEADTSTIQVGVNSNGQKFQL 528
D+ G ++G Y DL+ REGK N A +Q G +
Sbjct: 424 KDKATGEVLGQFYLDLYPREGK----------------YNHAACFGLQPGCLLPDGSRMM 467
Query: 529 PVISLVCDFRWVEVNMGDGKHQQMCLLQLNEIETLFHEMGHAMHSMLGRTQLQNVSGTRC 588
V +LV VN + LL+ +E+ T FHE GH MH + +T SGT
Sbjct: 468 AVAALV-------VNFSQPVAGRPSLLRHDEVRTYFHEFGHVMHQICAQTDFARFSGTNV 520
Query: 589 ATDFVELPSILMEHFARDTRVLSSISSHYKTGKSLDVEVLKNHQLENQFLQNCETFSQIK 648
TDFVE+PS ++E++ D L +S HYK G + ++L+ T QI
Sbjct: 521 ETDFVEVPSQMLENWVWDVDSLRRLSKHYKDGSPIADDLLEKLVASRLVNTGLLTLRQIV 580
Query: 649 MSFLDQELHNLDHTTDGSIDVIAIYHR-LERRLAVLPDDQSNWCGKFGHLF-GYGASYYS 706
+S +DQ LH T+ S+D + Y + L V +N FGHL GY YY
Sbjct: 581 LSKVDQSLH-----TNTSLDAASEYAKYCSEILGVAATPGTNMPATFGHLAGGYDGQYYG 635
Query: 707 YLFDRAIASKIWDHLFEQDP-FNRTNGTKFKEGLLQWGGSRDPWYLLSQVL 756
YL+ + ++ F+++ N G K++ +L+ GGS D +L L
Sbjct: 636 YLWSEVFSMDMFYSCFKKEGIMNPEVGMKYRNLILKPGGSLDGMDMLHNFL 686
>At5g65620 [O] KOG2089 Metalloendopeptidase family - saccharolysin & thimet
oligopeptidase
Length = 714
Score = 149 bits (375), Expect = 2e-35
Identities = 151/597 (25%), Positives = 247/597 (41%), Gaps = 70/597 (11%)
Query: 182 QCLRES-DVLGLDSEEIRTGKILLEDFEKSGIYMKPEIREKFIQLSQEISVIGQDFINNT 240
+ +RES D L R + +++ GI + E RE+F ++ QE+ + F N
Sbjct: 128 KAIRESPDWSSLSEARQRLVEAQIKEAVLIGIALDDEKREEFNKIEQELEKLSHKFSENV 187
Query: 241 EYVRSNYIKISCELMDAH---------VNKMVCSQMKKDITGE----YYKVPTYGYIP-- 285
+ K+ + + + S+ ++ T E + Y+P
Sbjct: 188 LDATKKFEKLITDKKEIEGLPPSALGLFAQAAVSKGHENATAENGPWIITLDAPSYLPVM 247
Query: 286 -HTLLRTCSDEVIRMKIWTEMHSCSDAQIER---LTKLISLRVELAKLLGSQNFAQYQLH 341
H R +EV R + S ++ + +++ LR+E AKLLG N+A+ +
Sbjct: 248 QHAKNRALREEVYR----AYLSRASSGDLDNTAIIDQILKLRLEKAKLLGYNNYAEVSMA 303
Query: 342 GKMAKTPENVSGFLESLVHSTRIKAASELKPLAVLKSELTGTQTPHTSEEVLELMKPWDR 401
KMA T E + LE L ++ A +++ L ++ + M WD
Sbjct: 304 MKMA-TVEKAAELLEKLRSASWDAAVQDMEDLKSFAKNQGAAES--------DSMTHWDT 354
Query: 402 DYYGSIQALAQRRSSSLD-NGESISSSFSLGVVMQGLSDLFEKIYGIKLVPATPKTGETW 460
++ + R S D N E + FSL VM GL L + ++GI + PA W
Sbjct: 355 TFWSE-----RLRESKYDINEEELRPYFSLPKVMDGLFSLAKTLFGIDIEPADG-LAPVW 408
Query: 461 SPDVRRIDVVDEHDGLIGVMYCDLFEREGKTPNPAHFTVCCSRNMYLNEADTSTIQVGVN 520
+ DVR V D I Y D + R + A SR+ + +
Sbjct: 409 NNDVRFYRVKDSSGNPIAYFYFDPYSRPSEKRGGAWMDEVVSRSRVMAQ----------- 457
Query: 521 SNGQKFQLPVISLVCDFRWVEVNMGDGKHQQMCLLQLNEIETLFHEMGHAMHSMLGRTQL 580
G +LPV +VC N + L+ E+ET+FHE GHA+ ML +
Sbjct: 458 -KGSSVRLPVAHMVC-------NQTPPVGDKPSLMTFREVETVFHEFGHALQHMLTKQDE 509
Query: 581 QNVSGTR-CATDFVELPSILMEHFARDTRVLSSISSHYKTGKSLDVEVLKNHQLENQFLQ 639
V+G R D VELPS ME++ L SI+ HY+TG++L EV K F
Sbjct: 510 GLVAGIRNIEWDAVELPSQFMENWCYHRDTLMSIAKHYETGETLPEEVYKKLLAARTFRA 569
Query: 640 NCETFSQIKMSFLDQELHNLDHTTDGSIDVIAIYHRLERRLAVLPD-DQSNWCGKFGHLF 698
+ Q+K + +D ELH + G + + R+ + V+P + + F H+F
Sbjct: 570 GSFSLRQLKFASVDLELHT-KYVPGGPESIYDVDQRVSVKTQVIPPLPEDRFLCSFSHIF 628
Query: 699 --GYGASYYSYLFDRAIASKIWDHLFEQDPFN-----RTNGTKFKEGLLQWGGSRDP 748
GY A YYSY + +++ + FE + + G +F+ +L GG + P
Sbjct: 629 AGGYAAGYYSYKWAEVLSADAFS-AFEDAGLDDIKAVKETGQRFRNTILALGGGKAP 684
>At5g10540 [O] KOG2089 Metalloendopeptidase family - saccharolysin & thimet
oligopeptidase
Length = 723
Score = 137 bits (345), Expect = 6e-32
Identities = 141/580 (24%), Positives = 235/580 (40%), Gaps = 81/580 (13%)
Query: 210 SGIYMKPEIREKFIQLSQEISVIGQDFINNTEYVRSNYIKISCELMDAH---------VN 260
SGI ++ + RE+F ++ QE+ + F N + K+ + +
Sbjct: 156 SGIALEDDKREEFNKIEQELEKLSHKFSENVLDATKKFEKLITDKKEIEGLPPSALGLFA 215
Query: 261 KMVCSQMKKDITGE----YYKVPTYGYIP---HTLLRTCSDEVIRMKIWTEMHSCSDAQI 313
+ S+ + T + + Y+P H R +EV R + S +
Sbjct: 216 QAAVSKGHETATADTGPWLITLDAPSYLPVMQHAKNRALREEVYR----AYLSRASSGDL 271
Query: 314 ER---LTKLISLRVELAKLLGSQNFAQYQLHGKMAKTPENVSGFLESLVHSTRIKAASEL 370
+ + +++ LR+E AKLLG +N+A+ + KMA T E LE L ++ A ++
Sbjct: 272 DNTAIIDQILKLRLEKAKLLGYRNYAEVSMATKMA-TVEKADELLEKLRSASWDPAVQDI 330
Query: 371 KPLAVLKSELTGTQTPHTSEEVLELMKPWDRDYYGSIQALAQRRSSSLD-NGESISSSFS 429
+ L + + + WD ++ + R S D N E + FS
Sbjct: 331 EDLKSFAKNQGAAEA--------DSLTHWDITFWSE-----RLRESKYDINEEELRPYFS 377
Query: 430 LGVVMQGLSDLFEKIYGIKLVPATPKTGETWSPDVRRIDVVDEHDGLIGVMYCDLFEREG 489
L VM L L + ++GI +VPA W+ DVR V D Y D + R
Sbjct: 378 LPKVMDALFGLAKTLFGIDVVPADG-VAPVWNSDVRFYCVKDSSGNPTAYFYFDPYSRPS 436
Query: 490 KTPNPAHFTVCCSRNMYLNEADTSTIQVGVNSNGQKFQLPVISLVCDFRWVEVNMGDGKH 549
+ + A SR+ + + G +LPV +VC N
Sbjct: 437 EKRDGAWMDEVFSRSRVMAQ------------KGSSVRLPVAQMVC-------NQTPPVG 477
Query: 550 QQMCLLQLNEIETLFHEMGHAMHSMLGRTQLQNVSGTR-CATDFVELPSILMEHFARDTR 608
+ L+ E+ET+FHE GHA+ ML + V+G R D VELPS ME++
Sbjct: 478 DKPSLMTFREVETVFHEFGHALQHMLTKEDEGLVAGIRNIEWDAVELPSQFMENWCYHRD 537
Query: 609 VLSSISSHYKTGKSLDVEVLKNHQLENQFLQNCETFSQIKMSFLDQELHNLDHTTDGSID 668
L SI+ HY+TG++L V K F + Q+K + +D ELH + G+
Sbjct: 538 TLMSIAKHYQTGETLPENVYKKLLAARTFRAGSLSLRQLKFATVDLELHT-KYMPGGAET 596
Query: 669 VIAIYHRLERRLAVLPD-DQSNWCGKFGHLF--------------GYGASYYSYLFDRAI 713
+ + R+ + V+P + + F H+F GY A YYSY + +
Sbjct: 597 IYEVDQRVSIKTQVIPPLPEDRFLCSFSHIFAVCFTCSPSHVLSGGYAAGYYSYKWAEVL 656
Query: 714 ASKIWDHLFEQDPFN-----RTNGTKFKEGLLQWGGSRDP 748
++ + FE + + G +F+ +L GG + P
Sbjct: 657 SADAFS-AFEDAGLDDIKAVKETGQRFRNTILALGGGKAP 695
>At1g67700 [O] KOG2089 Metalloendopeptidase family - saccharolysin & thimet
oligopeptidase
Length = 998
Score = 118 bits (296), Expect = 3e-26
Identities = 143/559 (25%), Positives = 226/559 (39%), Gaps = 65/559 (11%)
Query: 203 LLEDFEKSGIYMKPEIREKFIQLSQEISVIGQDFINNTEYVRSNYIKISCELMDAHVNKM 262
L+ DFE +G+ + RE+ +L EI + +I N S EL + +
Sbjct: 156 LVRDFEDNGLNLTAIKREEVERLKYEIDELSLRYIQNLNEDSSCLFFTEDELAGLPLEFL 215
Query: 263 VCSQMKKDITGEYYKVPTYGYIPHTLLRTCSDEVIRMKIWTEMHS-CSDAQIERLTKLIS 321
Q + + +K+ +L C R + C D I L +L+
Sbjct: 216 ---QNLEKTQNKEFKLTLESRHVAAILELCKIAKTRKTVAMAYGKRCGDTNIPVLQRLVQ 272
Query: 322 LRVELAKLLGSQNFAQYQLHGKMAKTPENVSGFLESLVHSTRIKAASELKPLAVLKSELT 381
R LA + G +FA Y L +M+KT V FLE + S A E L LK +
Sbjct: 273 SRHRLACVCGYAHFADYALDRRMSKTSMRVIRFLEDISSSLTDLAIREFSILEDLKRKEE 332
Query: 382 GTQTPHTSEEVLELMKPWDRDYYGSIQALAQRRSSSLDNGESISSSFSLGVVMQGLSDLF 441
G + P E++L +K + LD G+ I F + +V+ G+ +
Sbjct: 333 G-EIPFGVEDLLYYIKR------------VEELQFDLDFGD-IRQYFPVNLVLSGIFKIC 378
Query: 442 EKIYGIKLVPATPKTGETWSPDVRRIDVVDEHDG-LIGVMYCDLFEREGKTPNPAHFTVC 500
+ ++GIK T + W D+R V D G L+G Y D+F REGK H V
Sbjct: 379 QDLFGIKFEEVTEV--DVWYHDIRAFAVFDSGSGKLLGYFYLDMFTREGKCN---HSCVV 433
Query: 501 CSRNMYLNEADTSTIQVGVNSNGQKFQLPVISLVCDFRWVEVNMGDGKHQQMCLLQLNEI 560
+N L SNG Q+PV L+ F DG + + L +++
Sbjct: 434 ALQNNALF------------SNGA-CQIPVALLIAQFA------KDGSGEAVPL-GFSDV 473
Query: 561 ETLFHEMGHAMHSMLGRTQLQNVSGTRCATDFVELPSILMEHFARDTRVLSSISSHYKTG 620
LFHE GH + + R SG R DF E+PS L+E++ T
Sbjct: 474 VNLFHEFGHVVQHICNRASFARFSGLRVDPDFREIPSQLLENWQDIT------------- 520
Query: 621 KSLDVEVLKNHQLENQFLQNCETFSQIKMSFLDQELHNLDHTTDGSIDVIAIYHRLERRL 680
K L EV K + ++ +I DQ ++ +D D++ + L ++
Sbjct: 521 KPLVDEVCKTLKRWRYSFSALKSLQEILYCLFDQIIY-----SDDDADLLQLIRSLHPKV 575
Query: 681 AV-LP-DDQSNWCGKFGH-LFGYGASYYSYLFDRAIASKIWDHLFEQDPFNRTNGTKFKE 737
+ LP + +N F + G A+ YS L+ A+ I+ F N G +F++
Sbjct: 576 MIGLPVVEGTNPASCFPRAVIGSEATCYSRLWSEVYAADIFASKFGDGHPNLYAGLQFRD 635
Query: 738 GLLQWGGSRDPWYLLSQVL 756
+L GG ++P LL+ L
Sbjct: 636 KVLAPGGGKEPMELLTNFL 654
>7301239 [O] KOG2089 Metalloendopeptidase family - saccharolysin & thimet
oligopeptidase
Length = 730
Score = 89.4 bits (220), Expect = 2e-17
Identities = 113/488 (23%), Positives = 199/488 (40%), Gaps = 63/488 (12%)
Query: 276 YKVPTYGYIPHTLLRTCSDEVIRMKIWTEMHSCSDAQIER-------LTKLISLRVELAK 328
+K+ + L+ C + + R +W + +Q E+ + K+ LR A
Sbjct: 252 WKITLQPQVVDGFLKHCPERMQRWNVWRASVLKASSQQEKSLENSTHIEKIRGLRKRQAN 311
Query: 329 LLGSQNFAQYQLHGKMAKTPENVSGFLESLVHSTRIKAASELKPLAVLKSELTGTQTPHT 388
LLG ++FA + KM + +N+ L+ + EL+ +L G
Sbjct: 312 LLGYESFADMSMQTKMVGSVDNLKQIFAKLLKFAGPAQSVELE-------KLQGFAQDSG 364
Query: 389 SEEVLELMKPWDRDYYGSIQALAQRRSSSLDNGESISSSFSLGVVMQGLSDLFEKIYGIK 448
E LE +D Y+ Q A+ + + F L V+ GL L EK++GIK
Sbjct: 365 CEYKLE---AYDVAYWRRKQLAAEHGLQD----QKLREFFPLPRVLSGLFALSEKLFGIK 417
Query: 449 LVPATPKTGETWSPDVRRIDVVD----EHDGLIGVMYCDLFEREGKTPNPAHFTVCCSRN 504
+V E W P V+ DV D +G Y D + +E K RN
Sbjct: 418 IV--EQPNAEVWHPAVKFYDVFDADSVNSSTPVGGFYVDCYSKEHK----------FGRN 465
Query: 505 MYLNEADTSTIQVGV-NSNGQKFQLPVISLVCDFRWVEVNMGDGKHQQMCLLQLNEIETL 563
+ VG+ NSN P+ +L+ F + E D K LL ++++ L
Sbjct: 466 --------NGWMVGIRNSNKSAGLTPLCALI--FNFSEPQSPDAKPP---LLGYDDLQML 512
Query: 564 FHEMGHAMHSMLGRTQLQNVSG-TRCATDFVELPSILMEHFARDTRVLSSISSHYKTGKS 622
F G + +L + +++G + D ++ +M +F D V+ S+S H+ +G+
Sbjct: 513 FKTFGSGLQHLLTQAGYSDLAGLSNIEWDASQVSGHVMSNFLDDPTVIRSLSGHFSSGEP 572
Query: 623 LDVEVLKNHQLENQFLQNCETFSQIKMSFLDQELHNLDHTTDGSIDVIAIYHRLERRLAV 682
L+ E+ + +L L + ++ LD ELH + + + +L
Sbjct: 573 LEAELSQKMRLLKTQLAGYNLCQDLYLADLDVELHR------SNAFWLEVVRKLWPVYQC 626
Query: 683 LPDDQ--SNWCGKFGHLFG-YGASYYSYLFDRAIASKIWDHLFEQ--DPFNRTNGTKFKE 737
+P D+ ++ C G + A+ +S+L+ R IA+ I EQ + G ++K+
Sbjct: 627 MPLDKKDAHPCSLTDIFAGDWAAAQFSHLYSRLIAADISSSFAEQRSEENYAVVGRRYKQ 686
Query: 738 GLLQWGGS 745
L GGS
Sbjct: 687 TFLSCGGS 694
>Hs20543391 [O] KOG2090 Metalloendopeptidase family - mitochondrial
intermediate peptidase
Length = 210
Score = 77.8 bits (190), Expect = 6e-14
Identities = 40/81 (49%), Positives = 51/81 (62%), Gaps = 7/81 (8%)
Query: 526 FQLPVISLVCDFRWVEVNMGDGKHQQMCLLQLNEIETLFHEMGHAMHSMLGRTQLQNVSG 585
+QLPVI L+ +N+ LL +E L HEMGHAMHSMLGRT Q+++G
Sbjct: 136 YQLPVIVLM-------LNLPHSSRSSQTLLTPGMMENLDHEMGHAMHSMLGRTSYQHITG 188
Query: 586 TRCATDFVELPSILMEHFARD 606
TRC DF +PSIL+E+FA D
Sbjct: 189 TRCPIDFAGVPSILIEYFAND 209
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.320 0.136 0.402
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 47,064,532
Number of Sequences: 60738
Number of extensions: 2071780
Number of successful extensions: 5093
Number of sequences better than 1.0e-05: 15
Number of HSP's better than 0.0 without gapping: 10
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 5010
Number of HSP's gapped (non-prelim): 21
length of query: 779
length of database: 30,389,216
effective HSP length: 114
effective length of query: 665
effective length of database: 23,465,084
effective search space: 15604280860
effective search space used: 15604280860
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)