ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactII3342 check: MH T KOG0198 Signal transduction mechanisms MEKK and related serine/threonine protein kinases
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactII3342 1148198 1146009 -730
(730 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YLR362w [T] KOG0198 MEKK and related serine/threonine protein ki... 779 0.0
SPBC1D7.05c [T] KOG0198 MEKK and related serine/threonine protei... 301 3e-81
At1g09000 [T] KOG0198 MEKK and related serine/threonine protein ... 242 2e-63
At3g06030 [T] KOG0198 MEKK and related serine/threonine protein ... 238 2e-62
At1g54960 [T] KOG0198 MEKK and related serine/threonine protein ... 234 3e-61
At1g53570 [T] KOG0198 MEKK and related serine/threonine protein ... 229 1e-59
At1g63700 [T] KOG0198 MEKK and related serine/threonine protein ... 221 2e-57
YJL095w [T] KOG0198 MEKK and related serine/threonine protein ki... 220 5e-57
SPAC1F3.02c [T] KOG0198 MEKK and related serine/threonine protei... 216 1e-55
Hs4505153 [T] KOG0198 MEKK and related serine/threonine protein ... 212 1e-54
At5g66850 [T] KOG0198 MEKK and related serine/threonine protein ... 207 6e-53
HsM5729922 [T] KOG0198 MEKK and related serine/threonine protein... 199 1e-50
At3g13530 [T] KOG0198 MEKK and related serine/threonine protein ... 199 1e-50
Hs21735556 [T] KOG0198 MEKK and related serine/threonine protein... 199 2e-50
At4g08500 [T] KOG0198 MEKK and related serine/threonine protein ... 197 5e-50
At3g07980 [T] KOG0198 MEKK and related serine/threonine protein ... 197 6e-50
SPBC21.06c [T] KOG0198 MEKK and related serine/threonine protein... 196 1e-49
Hs22050308_2 [T] KOG0198 MEKK and related serine/threonine prote... 186 1e-46
At4g08480 [T] KOG0198 MEKK and related serine/threonine protein ... 184 3e-46
At4g08470 [T] KOG0198 MEKK and related serine/threonine protein ... 183 7e-46
SPAC9G1.02 [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 an... 176 1e-43
Hs4758702 [T] KOG4279 Serine/threonine protein kinase 172 2e-42
Hs5174547 [T] KOG4279 Serine/threonine protein kinase 169 1e-41
At4g12020_6 [T] KOG0198 MEKK and related serine/threonine protei... 168 2e-41
7300559 [T] KOG4279 Serine/threonine protein kinase 164 3e-40
7300435 [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and r... 164 3e-40
YCR073c [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and r... 162 2e-39
YNR031c [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and r... 160 8e-39
Hs4505599 [T] KOG0578 p21-activated serine/threonine protein kinase 159 1e-38
HsM5454174 [T] KOG0201 Serine/threonine protein kinase 156 9e-38
Hs21361358 [T] KOG0201 Serine/threonine protein kinase 156 9e-38
CE28674 [T] KOG0201 Serine/threonine protein kinase 155 3e-37
CE07510 [T] KOG0201 Serine/threonine protein kinase 154 4e-37
Hs4505601 [T] KOG0578 p21-activated serine/threonine protein kinase 154 5e-37
Hs7382496 [T] KOG0578 p21-activated serine/threonine protein kinase 154 6e-37
Hs15011880 [T] KOG0201 Serine/threonine protein kinase 154 6e-37
CE27177 [T] KOG4279 Serine/threonine protein kinase 153 8e-37
7300224 [T] KOG0201 Serine/threonine protein kinase 153 8e-37
7298926 [T] KOG0578 p21-activated serine/threonine protein kinase 153 8e-37
At5g55090 [T] KOG0198 MEKK and related serine/threonine protein ... 152 2e-36
CE27670 [T] KOG0578 p21-activated serine/threonine protein kinase 151 4e-36
At4g26890 [T] KOG0198 MEKK and related serine/threonine protein ... 150 5e-36
Hs20070158 [T] KOG0201 Serine/threonine protein kinase 149 1e-35
Hs6031180 [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and... 148 3e-35
Hs5803088 [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and... 148 3e-35
At3g15220 [T] KOG0201 Serine/threonine protein kinase 147 6e-35
YNL298w [T] KOG0578 p21-activated serine/threonine protein kinase 146 1e-34
SPAC9G1.09 [T] KOG0201 Serine/threonine protein kinase 146 1e-34
At1g53165 [T] KOG0201 Serine/threonine protein kinase 142 2e-33
Hs8393810_1 [T] KOG0587 Traf2- and Nck-interacting kinase and re... 140 5e-33
Hs20544910_1 [T] KOG0587 Traf2- and Nck-interacting kinase and r... 140 5e-33
At2g32510 [T] KOG0198 MEKK and related serine/threonine protein ... 140 7e-33
YAR019c [T] KOG0198 MEKK and related serine/threonine protein ki... 139 2e-32
Hs13376582 [T] KOG0198 MEKK and related serine/threonine protein... 139 2e-32
SPAC2C4.14c [T] KOG0201 Serine/threonine protein kinase 139 2e-32
Hs15451902 [T] KOG0576 Mitogen-activated protein kinase kinase k... 139 2e-32
Hs5174701 [T] KOG0579 Ste20-like serine/threonine protein kinase 138 3e-32
SPBC1604.14c [T] KOG0578 p21-activated serine/threonine protein ... 137 8e-32
Hs5454096 [T] KOG0574 STE20-like serine/threonine kinase MST 137 8e-32
Hs14589909 [T] KOG0576 Mitogen-activated protein kinase kinase k... 135 2e-31
YHL007c [T] KOG0578 p21-activated serine/threonine protein kinase 135 2e-31
SPCC320.12c [D] KOG0580 Serine/threonine protein kinase 135 2e-31
SPAC1F5.09c [T] KOG0578 p21-activated serine/threonine protein k... 135 3e-31
At1g07150 [T] KOG0198 MEKK and related serine/threonine protein ... 135 3e-31
YHR102w [T] KOG0201 Serine/threonine protein kinase 134 4e-31
Hs5454094 [T] KOG0574 STE20-like serine/threonine kinase MST 134 5e-31
Hs16178962 [T] KOG0574 STE20-like serine/threonine kinase MST 134 5e-31
Hs22035600 [T] KOG0576 Mitogen-activated protein kinase kinase k... 133 8e-31
CE28273 [T] KOG0587 Traf2- and Nck-interacting kinase and relate... 133 8e-31
CE25673 [T] KOG0587 Traf2- and Nck-interacting kinase and relate... 133 8e-31
CE25672 [T] KOG0587 Traf2- and Nck-interacting kinase and relate... 133 8e-31
HsM4758524 [T] KOG0587 Traf2- and Nck-interacting kinase and rel... 133 1e-30
Hs22035606 [T] KOG0587 Traf2- and Nck-interacting kinase and rel... 133 1e-30
Hs22035604 [T] KOG0587 Traf2- and Nck-interacting kinase and rel... 133 1e-30
Hs22035602 [T] KOG0587 Traf2- and Nck-interacting kinase and rel... 133 1e-30
SPBC17F3.02 [T] KOG0201 Serine/threonine protein kinase 132 1e-30
HsM4759010 [T] KOG0576 Mitogen-activated protein kinase kinase k... 132 1e-30
7302511 [T] KOG0576 Mitogen-activated protein kinase kinase kina... 132 2e-30
YOL113w [T] KOG0578 p21-activated serine/threonine protein kinase 132 2e-30
7300149 [T] KOG0578 p21-activated serine/threonine protein kinase 131 3e-30
Hs7657335 [T] KOG0587 Traf2- and Nck-interacting kinase and rela... 131 4e-30
Hs14771959 [T] KOG0578 p21-activated serine/threonine protein ki... 130 5e-30
At3g61960 [OUT] KOG0595 Serine/threonine-protein kinase involved... 130 7e-30
At1g05100 [T] KOG0198 MEKK and related serine/threonine protein ... 130 7e-30
Hs9910476 [T] KOG0578 p21-activated serine/threonine protein kinase 129 2e-29
7291778 [T] KOG0579 Ste20-like serine/threonine protein kinase 129 2e-29
Hs20428779_1 [T] KOG0587 Traf2- and Nck-interacting kinase and r... 129 2e-29
CE27965 [T] KOG0574 STE20-like serine/threonine kinase MST 129 2e-29
CE27726 [T] KOG0574 STE20-like serine/threonine kinase MST 129 2e-29
CE27082 [T] KOG0574 STE20-like serine/threonine kinase MST 129 2e-29
CE07064 [T] KOG0574 STE20-like serine/threonine kinase MST 129 2e-29
Hs18602554 [T] KOG0578 p21-activated serine/threonine protein ki... 128 3e-29
7292249 [T] KOG0587 Traf2- and Nck-interacting kinase and relate... 128 4e-29
Hs5031975 [T] KOG0578 p21-activated serine/threonine protein kinase 127 6e-29
At1g69220 [T] KOG0576 Mitogen-activated protein kinase kinase ki... 127 6e-29
SPCC18B5.11c [D] KOG0615 Serine/threonine protein kinase Chk2 an... 127 8e-29
Hs7661994 [T] KOG0579 Ste20-like serine/threonine protein kinase 126 1e-28
At2g30040 [T] KOG0198 MEKK and related serine/threonine protein ... 126 1e-28
SPBC4F6.06 [T] KOG0583 Serine/threonine protein kinase 125 2e-28
YPL209c [D] KOG0580 Serine/threonine protein kinase 125 2e-28
Hs19923464 [T] KOG0577 Serine/threonine protein kinase 125 3e-28
CE07599 [T] KOG0576 Mitogen-activated protein kinase kinase kina... 125 3e-28
CE27573 [T] KOG0198 MEKK and related serine/threonine protein ki... 124 4e-28
CE07737 [T] KOG0198 MEKK and related serine/threonine protein ki... 124 4e-28
At4g29810 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 124 4e-28
YBR028c [RT] KOG0598 Ribosomal protein S6 kinase and related pro... 124 7e-28
At1g49180_1 [OUT] KOG0595 Serine/threonine-protein kinase involv... 123 9e-28
HsM5454184 [T] KOG4721 Serine/threonine protein kinase contains ... 123 1e-27
HsM4507279 [D] KOG0580 Serine/threonine protein kinase 123 1e-27
Hs21735552 [T] KOG4721 Serine/threonine protein kinase contains ... 123 1e-27
YFR014c [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-... 122 1e-27
YDR523c [T] KOG0201 Serine/threonine protein kinase 122 1e-27
Hs20547806 [R] KOG0589 Serine/threonine protein kinase 122 1e-27
7293761 [T] KOG4721 Serine/threonine protein kinase contains leu... 122 1e-27
YOL100w [T] KOG0592 3-phosphoinositide-dependent protein kinase ... 122 2e-27
At5g14720 [T] KOG0582 Ste20-like serine/threonine protein kinase 122 2e-27
At1g51660 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 122 2e-27
Hs4507275 [D] KOG0580 Serine/threonine protein kinase 121 3e-27
YPL203w [T] KOG0616 cAMP-dependent protein kinase catalytic subu... 121 4e-27
YKL101w [D] KOG0588 Serine/threonine protein kinase 121 4e-27
Hs6005810 [T] KOG0576 Mitogen-activated protein kinase kinase ki... 121 4e-27
At5g67080 [T] KOG0198 MEKK and related serine/threonine protein ... 121 4e-27
7302458 [T] KOG0574 STE20-like serine/threonine kinase MST 121 4e-27
CE23001 [R] KOG0589 Serine/threonine protein kinase 120 6e-27
At2g37840 [OUT] KOG0595 Serine/threonine-protein kinase involved... 120 6e-27
Hs4758696 [T] KOG4721 Serine/threonine protein kinase contains l... 120 7e-27
CE23702 [T] KOG4721 Serine/threonine protein kinase contains leu... 120 1e-26
YDR507c [D] KOG0588 Serine/threonine protein kinase 119 2e-26
SPBC32C12.03c [T] KOG0583 Serine/threonine protein kinase 118 3e-26
CE21615 [T] KOG0578 p21-activated serine/threonine protein kinase 118 3e-26
CE09360 [Z] KOG0613 Projectin/twitchin and related proteins 118 3e-26
CE20564 [T] KOG0578 p21-activated serine/threonine protein kinase 118 4e-26
CE05425 [T] KOG0578 p21-activated serine/threonine protein kinase 118 4e-26
Hs4826878 [T] KOG0582 Ste20-like serine/threonine protein kinase 117 5e-26
At3g45790 [T] KOG0198 MEKK and related serine/threonine protein ... 117 5e-26
At3g46140 [T] KOG0198 MEKK and related serine/threonine protein ... 117 8e-26
At3g08720 [RT] KOG0598 Ribosomal protein S6 kinase and related p... 117 8e-26
7290841 [D] KOG0591 NIMA (never in mitosis)-related G2-specific ... 117 8e-26
At5g25110 [T] KOG0583 Serine/threonine protein kinase 116 1e-25
At5g40440 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 116 1e-25
SPCC16C4.11 [R] KOG0594 Protein kinase PCTAIRE and related kinases 115 2e-25
At4g26070 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 115 2e-25
At3g08730 [RT] KOG0598 Ribosomal protein S6 kinase and related p... 115 2e-25
At2g45490 [D] KOG0580 Serine/threonine protein kinase 115 2e-25
YJL164c [T] KOG0616 cAMP-dependent protein kinase catalytic subu... 115 3e-25
Hs4506055 [T] KOG0616 cAMP-dependent protein kinase catalytic su... 115 3e-25
Hs4505373 [V] KOG1826 Ras GTPase activating protein RasGAP/neuro... 115 3e-25
SPAC2F3.15 [D] KOG0600 Cdc2-related protein kinase 114 4e-25
Hs4758016 [D] KOG0575 Polo-like serine/threonine protein kinase 114 4e-25
At2g30360 [T] KOG0583 Serine/threonine protein kinase 114 5e-25
Hs7706401 [T] KOG0577 Serine/threonine protein kinase 114 7e-25
Hs4759208 [T] KOG0577 Serine/threonine protein kinase 114 7e-25
Hs4507831 [OUT] KOG0595 Serine/threonine-protein kinase involved... 114 7e-25
YLR096w [T] KOG0583 Serine/threonine protein kinase 113 9e-25
Hs7657526 [T] KOG0603 Ribosomal protein S6 kinase 113 9e-25
Hs15619015 [T] KOG0616 cAMP-dependent protein kinase catalytic s... 113 9e-25
YKL166c [T] KOG0616 cAMP-dependent protein kinase catalytic subu... 113 1e-24
CE24761 [D] KOG0580 Serine/threonine protein kinase 113 1e-24
At3g21220 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 112 2e-24
SPCC4G3.08 [RT] KOG0598 Ribosomal protein S6 kinase and related ... 112 2e-24
At2g25090 [T] KOG0583 Serine/threonine protein kinase 112 2e-24
Hs20547878 [R] KOG0589 Serine/threonine protein kinase 112 3e-24
Hs19923570 [T] KOG0603 Ribosomal protein S6 kinase 112 3e-24
At5g62310 [TR] KOG0606 Microtubule-associated serine/threonine k... 112 3e-24
At5g10930 [T] KOG0583 Serine/threonine protein kinase 112 3e-24
7301213 [R] KOG0589 Serine/threonine protein kinase 112 3e-24
7298323 [D] KOG0590 Checkpoint kinase and related serine/threoni... 112 3e-24
At5g03730 [T] KOG0192 Tyrosine kinase specific for activated (GT... 111 3e-24
Hs19311016_1 [R] KOG0589 Serine/threonine protein kinase 111 3e-24
Hs20149547 [T] KOG0603 Ribosomal protein S6 kinase 111 4e-24
CE15475 [T] KOG0616 cAMP-dependent protein kinase catalytic subu... 111 4e-24
CE15473 [T] KOG0616 cAMP-dependent protein kinase catalytic subu... 111 4e-24
At4g18700 [T] KOG0583 Serine/threonine protein kinase 111 4e-24
At3g50310 [T] KOG0198 MEKK and related serine/threonine protein ... 111 4e-24
At3g23000 [T] KOG0583 Serine/threonine protein kinase 111 4e-24
SPAC19E9.02 [D] KOG0591 NIMA (never in mitosis)-related G2-speci... 110 6e-24
CE15235 [R] KOG0589 Serine/threonine protein kinase 110 6e-24
7297542 [T] KOG0616 cAMP-dependent protein kinase catalytic subu... 110 6e-24
YCL024w [T] KOG0583 Serine/threonine protein kinase 110 8e-24
At5g58950 [T] KOG0192 Tyrosine kinase specific for activated (GT... 110 8e-24
At5g39420 [D] KOG0600 Cdc2-related protein kinase 110 8e-24
At5g35410 [T] KOG0583 Serine/threonine protein kinase 110 8e-24
At4g14580 [T] KOG0583 Serine/threonine protein kinase 110 8e-24
Hs4506057 [T] KOG0616 cAMP-dependent protein kinase catalytic su... 110 1e-23
Hs4502803 [D] KOG0590 Checkpoint kinase and related serine/threo... 110 1e-23
CE28218 [D] KOG0588 Serine/threonine protein kinase 110 1e-23
Hs4505695 [T] KOG0592 3-phosphoinositide-dependent protein kinas... 109 1e-23
Hs18552621 [R] KOG0597 Serine-threonine protein kinase FUSED 109 1e-23
At1g73660 [T] KOG0192 Tyrosine kinase specific for activated (GT... 109 1e-23
YDR466w [T] KOG0592 3-phosphoinositide-dependent protein kinase ... 109 2e-23
At1g33770 [D] KOG0600 Cdc2-related protein kinase 109 2e-23
Hs7019543 [T] KOG0582 Ste20-like serine/threonine protein kinase 108 2e-23
Hs4759050 [T] KOG0603 Ribosomal protein S6 kinase 108 2e-23
At4g23050 [T] KOG0192 Tyrosine kinase specific for activated (GT... 108 2e-23
At3g04810 [R] KOG0589 Serine/threonine protein kinase 108 2e-23
At2g17700 [T] KOG0192 Tyrosine kinase specific for activated (GT... 108 2e-23
7291037 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K) 108 2e-23
YPL140c [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K) 108 3e-23
YKL139w [D] KOG0600 Cdc2-related protein kinase 108 3e-23
Hs7662210 [OUT] KOG0595 Serine/threonine-protein kinase involved... 108 3e-23
CE18169 [T] KOG0603 Ribosomal protein S6 kinase 108 3e-23
CE13014 [T] KOG0603 Ribosomal protein S6 kinase 108 3e-23
At4g35780 [T] KOG0192 Tyrosine kinase specific for activated (GT... 108 3e-23
At2g26980 [T] KOG0583 Serine/threonine protein kinase 108 3e-23
7293601 [T] KOG0577 Serine/threonine protein kinase 108 3e-23
YPL031c [R] KOG0594 Protein kinase PCTAIRE and related kinases 108 4e-23
Hs7661974 [T] KOG0583 Serine/threonine protein kinase 108 4e-23
Hs5730055 [D] KOG0575 Polo-like serine/threonine protein kinase 108 4e-23
Hs10835065 [T] KOG0616 cAMP-dependent protein kinase catalytic s... 108 4e-23
CE27768 [R] KOG0586 Serine/threonine protein kinase 108 4e-23
CE26212 [T] KOG0582 Ste20-like serine/threonine protein kinase 108 4e-23
CE23838 [R] KOG0586 Serine/threonine protein kinase 108 4e-23
At5g45810 [T] KOG0583 Serine/threonine protein kinase 108 4e-23
At4g10010 [D] KOG0600 Cdc2-related protein kinase 108 4e-23
At3g01090 [T] KOG0583 Serine/threonine protein kinase 108 4e-23
At2g05060 [T] KOG0198 MEKK and related serine/threonine protein ... 108 4e-23
7302464 [R] KOG0586 Serine/threonine protein kinase 108 4e-23
YPL153c [D] KOG0615 Serine/threonine protein kinase Chk2 and rel... 107 5e-23
Hs4826948 [T] KOG0616 cAMP-dependent protein kinase catalytic su... 107 5e-23
Hs16936528 [R] KOG0594 Protein kinase PCTAIRE and related kinases 107 5e-23
At5g01810 [T] KOG0583 Serine/threonine protein kinase 107 5e-23
At4g38470 [T] KOG0192 Tyrosine kinase specific for activated (GT... 107 5e-23
At3g17850 [TR] KOG0606 Microtubule-associated serine/threonine k... 107 5e-23
At1g18160 [T] KOG0192 Tyrosine kinase specific for activated (GT... 107 5e-23
7294537 [OUT] KOG0595 Serine/threonine-protein kinase involved i... 107 5e-23
At3g29160 [T] KOG0583 Serine/threonine protein kinase 107 6e-23
SPAC57A10.02 [D] KOG0588 Serine/threonine protein kinase 107 8e-23
At5g07070 [T] KOG0583 Serine/threonine protein kinase 107 8e-23
At5g01820 [T] KOG0583 Serine/threonine protein kinase 107 8e-23
7297240_1 [T] KOG0587 Traf2- and Nck-interacting kinase and rela... 107 8e-23
SPBC106.10 [T] KOG0616 cAMP-dependent protein kinase catalytic s... 106 1e-22
HsM7657627 [D] KOG0575 Polo-like serine/threonine protein kinase 106 1e-22
Hs4759178 [D] KOG0580 Serine/threonine protein kinase 106 1e-22
Hs21361433 [D] KOG0575 Polo-like serine/threonine protein kinase 106 1e-22
Hs19424132 [D] KOG0591 NIMA (never in mitosis)-related G2-specif... 106 1e-22
CE21025 [D] KOG0580 Serine/threonine protein kinase 106 1e-22
At4g30960 [T] KOG0583 Serine/threonine protein kinase 106 1e-22
At1g45160 [TR] KOG0606 Microtubule-associated serine/threonine k... 106 1e-22
At1g18350 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 106 1e-22
CE22045 [RT] KOG0598 Ribosomal protein S6 kinase and related pro... 106 1e-22
At5g56580 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 106 1e-22
At5g04510 [T] KOG0592 3-phosphoinositide-dependent protein kinas... 106 1e-22
YOR231w [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K) 105 2e-22
Hs4826776 [T] KOG0197 Tyrosine kinases 105 2e-22
Hs4502709 [R] KOG0594 Protein kinase PCTAIRE and related kinases 105 2e-22
Hs14196445 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase ... 105 2e-22
Hs13489054 [T] KOG0581 Mitogen-activated protein kinase kinase (... 105 2e-22
At5g45820 [T] KOG0583 Serine/threonine protein kinase 105 2e-22
At5g39440 [T] KOG0583 Serine/threonine protein kinase 105 2e-22
At5g27510 [T] KOG0198 MEKK and related serine/threonine protein ... 105 2e-22
7290147 [T] KOG0583 Serine/threonine protein kinase 105 2e-22
Hs4507277_1 [R] KOG0589 Serine/threonine protein kinase 105 2e-22
At3g46920_2 [T] KOG0192 Tyrosine kinase specific for activated (... 105 2e-22
YDR122w [T] KOG0583 Serine/threonine protein kinase 105 2e-22
At2g24360 [T] KOG0192 Tyrosine kinase specific for activated (GT... 105 2e-22
ECU07g0360 [D] KOG0580 Serine/threonine protein kinase 105 3e-22
At5g12090 [T] KOG0198 MEKK and related serine/threonine protein ... 105 3e-22
At1g08650 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 105 3e-22
YOL016c [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-... 104 4e-22
Hs5579478 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 104 4e-22
Hs4506737 [RT] KOG0598 Ribosomal protein S6 kinase and related p... 104 4e-22
At1g71530 [D] KOG0600 Cdc2-related protein kinase 104 4e-22
Hs4557439 [R] KOG0594 Protein kinase PCTAIRE and related kinases 104 5e-22
Hs4505649 [R] KOG0594 Protein kinase PCTAIRE and related kinases 104 5e-22
At3g06640 [T] KOG0192 Tyrosine kinase specific for activated (GT... 104 5e-22
At1g30270 [T] KOG0583 Serine/threonine protein kinase 104 5e-22
CE07905 [T] KOG0579 Ste20-like serine/threonine protein kinase 103 7e-22
At4g24400 [T] KOG0583 Serine/threonine protein kinase 103 7e-22
At1g14000 [T] KOG0192 Tyrosine kinase specific for activated (GT... 103 7e-22
7292375 [R] KOG0594 Protein kinase PCTAIRE and related kinases 103 7e-22
YMR001c [D] KOG0575 Polo-like serine/threonine protein kinase 103 9e-22
SPBC543.07 [T] KOG0581 Mitogen-activated protein kinase kinase (... 103 9e-22
SPBC409.07c [T] KOG0581 Mitogen-activated protein kinase kinase ... 103 9e-22
Hs20479818 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase ... 103 9e-22
CE05780 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-... 103 9e-22
At4g31170 [T] KOG0192 Tyrosine kinase specific for activated (GT... 103 9e-22
CE24516 [OUT] KOG0595 Serine/threonine-protein kinase involved i... 103 1e-21
At2g34180 [T] KOG0583 Serine/threonine protein kinase 103 1e-21
7304283 [Z] KOG0613 Projectin/twitchin and related proteins 103 1e-21
7290150 [T] KOG0583 Serine/threonine protein kinase 103 1e-21
Hs22065589 [T] KOG0587 Traf2- and Nck-interacting kinase and rel... 102 2e-21
At5g50860 [D] KOG0600 Cdc2-related protein kinase 102 2e-21
At2g41140 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 102 2e-21
At1g54510 [R] KOG0589 Serine/threonine protein kinase 102 2e-21
At1g48260 [T] KOG0583 Serine/threonine protein kinase 102 2e-21
7300650 [R] KOG0594 Protein kinase PCTAIRE and related kinases 102 2e-21
7299536 [D] KOG0580 Serine/threonine protein kinase 102 2e-21
Hs5453860 [R] KOG0594 Protein kinase PCTAIRE and related kinases 102 2e-21
Hs20545245 [D] KOG0588 Serine/threonine protein kinase 102 2e-21
Hs15011928 [R] KOG0594 Protein kinase PCTAIRE and related kinases 102 2e-21
At3g56760 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 102 2e-21
At3g06630 [T] KOG0192 Tyrosine kinase specific for activated (GT... 102 2e-21
At1g67890 [T] KOG0192 Tyrosine kinase specific for activated (GT... 102 2e-21
YDR490c [T] KOG0592 3-phosphoinositide-dependent protein kinase ... 102 3e-21
Hs13899225 [R] KOG0586 Serine/threonine protein kinase 102 3e-21
At3g19100 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 102 3e-21
At1g25390 [T] KOG1187 Serine/threonine protein kinase 102 3e-21
At5g57610_2 [T] KOG0192 Tyrosine kinase specific for activated (... 102 3e-21
Hs7657214 [T] KOG0583 Serine/threonine protein kinase 101 4e-21
Hs5453970 [T] KOG0694 Serine/threonine protein kinase 101 4e-21
Hs14735945 [T] KOG0694 Serine/threonine protein kinase 101 4e-21
CE26649 [D] KOG0575 Polo-like serine/threonine protein kinase 101 4e-21
CE22877 [D] KOG0575 Polo-like serine/threonine protein kinase 101 4e-21
CE03232 [D] KOG0591 NIMA (never in mitosis)-related G2-specific ... 101 4e-21
Hs9845489 [R] KOG0586 Serine/threonine protein kinase 101 5e-21
Hs9845487 [R] KOG0586 Serine/threonine protein kinase 101 5e-21
Hs7706601 [T] KOG0192 Tyrosine kinase specific for activated (GT... 101 5e-21
Hs22062450 [R] KOG0586 Serine/threonine protein kinase 101 5e-21
Hs19526767 [T] KOG0192 Tyrosine kinase specific for activated (G... 101 5e-21
CE09689 [T] KOG0194 Protein tyrosine kinase 101 5e-21
CE04603 [T] KOG0616 cAMP-dependent protein kinase catalytic subu... 101 5e-21
At5g58380 [T] KOG0583 Serine/threonine protein kinase 101 5e-21
At5g28290 [R] KOG0589 Serine/threonine protein kinase 101 5e-21
At3g10540 [T] KOG0592 3-phosphoinositide-dependent protein kinas... 101 5e-21
At1g73500 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 101 5e-21
At1g50230 [R] KOG0597 Serine-threonine protein kinase FUSED 101 5e-21
7299437 [R] KOG0586 Serine/threonine protein kinase 101 5e-21
7299322 [R] KOG0611 Predicted serine/threonine protein kinase 101 5e-21
SPAC1B9.02c [RT] KOG0598 Ribosomal protein S6 kinase and related... 100 6e-21
Hs7705551 [T] KOG0661 MAPK related serine/threonine protein kinase 100 6e-21
Hs4557681 [T] KOG0197 Tyrosine kinases 100 6e-21
Hs21359873 [D] KOG0575 Polo-like serine/threonine protein kinase 100 6e-21
At5g41990 [R] KOG0584 Serine/threonine protein kinase 100 6e-21
At2g42550 [T] KOG0198 MEKK and related serine/threonine protein ... 100 6e-21
At1g29230 [T] KOG0583 Serine/threonine protein kinase 100 6e-21
7300413 [T] KOG0583 Serine/threonine protein kinase 100 6e-21
7294217 [D] KOG0588 Serine/threonine protein kinase 100 6e-21
Hs8923922 [R] KOG0586 Serine/threonine protein kinase 100 8e-21
Hs4557511 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 100 8e-21
ECU07g0520 [T] KOG0616 cAMP-dependent protein kinase catalytic s... 100 8e-21
At5g64960 [D] KOG0600 Cdc2-related protein kinase 100 8e-21
At3g50530 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 100 8e-21
At3g17510 [T] KOG0583 Serine/threonine protein kinase 100 8e-21
At2g46700 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 100 8e-21
At1g01140 [T] KOG0583 Serine/threonine protein kinase 100 8e-21
7295426 [RT] KOG0598 Ribosomal protein S6 kinase and related pro... 100 8e-21
Hs5453964 [T] KOG0583 Serine/threonine protein kinase 100 1e-20
Hs14756717 [T] KOG0197 Tyrosine kinases 100 1e-20
At1g48490 [TR] KOG0606 Microtubule-associated serine/threonine k... 100 1e-20
7290903 [T] KOG0192 Tyrosine kinase specific for activated (GTP-... 100 1e-20
At2g35050_2 [T] KOG0192 Tyrosine kinase specific for activated (... 100 1e-20
HsM4826916 [D] KOG0575 Polo-like serine/threonine protein kinase 100 1e-20
Hs9966875 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 100 1e-20
Hs4507749 [T] KOG0197 Tyrosine kinases 100 1e-20
Hs4507273 [D] KOG0580 Serine/threonine protein kinase 100 1e-20
Hs14777335 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase ... 100 1e-20
Hs14110390 [D] KOG0600 Cdc2-related protein kinase 100 1e-20
Hs14110387 [D] KOG0600 Cdc2-related protein kinase 100 1e-20
Hs11496279 [T] KOG0661 MAPK related serine/threonine protein kinase 100 1e-20
CE00315 [R] KOG0594 Protein kinase PCTAIRE and related kinases 100 1e-20
YJL128c [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K) 99 2e-20
Hs7662388 [T] KOG0661 MAPK related serine/threonine protein kinase 99 2e-20
Hs7019489 [T] KOG0694 Serine/threonine protein kinase 99 2e-20
Hs14993776 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase ... 99 2e-20
CE28479 [T] KOG0583 Serine/threonine protein kinase 99 2e-20
CE28251 [D] KOG0615 Serine/threonine protein kinase Chk2 and rel... 99 2e-20
CE25046 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-... 99 2e-20
At3g49370 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 99 2e-20
At1g09600 [D] KOG0600 Cdc2-related protein kinase 99 2e-20
7295638 [T] KOG0603 Ribosomal protein S6 kinase 99 2e-20
HsM4505103 [R] KOG0586 Serine/threonine protein kinase 99 2e-20
Hs14150045 [T] KOG0585 Ca2+/calmodulin-dependent protein kinase ... 99 2e-20
At5g49470 [T] KOG0192 Tyrosine kinase specific for activated (GT... 99 2e-20
At1g49580 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 99 2e-20
7298652 [D] KOG0615 Serine/threonine protein kinase Chk2 and rel... 99 2e-20
7297080 [T] KOG0583 Serine/threonine protein kinase 99 2e-20
7296450 [D] KOG0575 Polo-like serine/threonine protein kinase 99 2e-20
SPCC63.08c [OUT] KOG0595 Serine/threonine-protein kinase involve... 99 3e-20
SPCC576.15c [T] KOG0592 3-phosphoinositide-dependent protein kin... 99 3e-20
Hs6912584 [R] KOG0594 Protein kinase PCTAIRE and related kinases 99 3e-20
Hs4506735 [T] KOG0603 Ribosomal protein S6 kinase 99 3e-20
ECU01g0630 [D] KOG0575 Polo-like serine/threonine protein kinase 99 3e-20
CE17284 [T] KOG0583 Serine/threonine protein kinase 99 3e-20
At4g23650 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 99 3e-20
At2g17890 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 99 3e-20
At1g70430 [T] KOG0582 Ste20-like serine/threonine protein kinase 99 3e-20
SPAC23H4.02 [T] KOG0583 Serine/threonine protein kinase 98 4e-20
Hs4504803 [T] KOG0197 Tyrosine kinases 98 4e-20
Hs19923407 [D] KOG0591 NIMA (never in mitosis)-related G2-specif... 98 4e-20
CE27297 [D] KOG0615 Serine/threonine protein kinase Chk2 and rel... 98 4e-20
CE20493 [TR] KOG0606 Microtubule-associated serine/threonine kin... 98 4e-20
At5g10270 [D] KOG0600 Cdc2-related protein kinase 98 4e-20
At3g24540 [T] KOG1187 Serine/threonine protein kinase 98 4e-20
At3g06620 [T] KOG0192 Tyrosine kinase specific for activated (GT... 98 4e-20
At3g05050 [D] KOG0600 Cdc2-related protein kinase 98 4e-20
7297680 [R] KOG0594 Protein kinase PCTAIRE and related kinases 98 4e-20
CE26793_1 [R] KOG0611 Predicted serine/threonine protein kinase 98 4e-20
YDL159w [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K) 98 5e-20
Hs5453966 [T] KOG0583 Serine/threonine protein kinase 98 5e-20
Hs4506075 [T] KOG4236 Serine/threonine protein kinase PKC mu/PKD... 98 5e-20
At1g53050 [D] KOG0600 Cdc2-related protein kinase 98 5e-20
Hs4826684_1 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase... 98 5e-20
Hs7706549 [D] KOG0600 Cdc2-related protein kinase 97 7e-20
Hs5453974 [T] KOG0694 Serine/threonine protein kinase 97 7e-20
Hs16160923 [R] KOG0594 Protein kinase PCTAIRE and related kinases 97 7e-20
CE29298 [T] KOG0690 Serine/threonine protein kinase 97 7e-20
CE18646 [T] KOG0690 Serine/threonine protein kinase 97 7e-20
CE17354 [T] KOG0694 Serine/threonine protein kinase 97 7e-20
CE17353 [T] KOG0694 Serine/threonine protein kinase 97 7e-20
At3g46160 [T] KOG0198 MEKK and related serine/threonine protein ... 97 7e-20
At1g04700_2 [T] KOG0192 Tyrosine kinase specific for activated (... 97 7e-20
SPCC24B10.07 [RT] KOG0598 Ribosomal protein S6 kinase and relate... 97 9e-20
Hs4505397 [T] KOG0198 MEKK and related serine/threonine protein ... 97 9e-20
CE27166 [T] KOG0616 cAMP-dependent protein kinase catalytic subu... 97 9e-20
CE21879 [D] KOG0590 Checkpoint kinase and related serine/threoni... 97 9e-20
CE19294 [T] KOG0198 MEKK and related serine/threonine protein ki... 97 9e-20
At3g45670 [T] KOG0198 MEKK and related serine/threonine protein ... 97 9e-20
At1g62400 [T] KOG0192 Tyrosine kinase specific for activated (GT... 97 9e-20
At4g10730 [T] KOG0582 Ste20-like serine/threonine protein kinase 97 1e-19
At3g18750 [R] KOG0584 Serine/threonine protein kinase 97 1e-19
SPBC4C3.11 [T] KOG0592 3-phosphoinositide-dependent protein kina... 96 1e-19
Hs5453976 [T] KOG0694 Serine/threonine protein kinase 96 1e-19
Hs4502553 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 96 1e-19
CE29411 [T] KOG0194 Protein tyrosine kinase 96 1e-19
At3g20860 [R] KOG0589 Serine/threonine protein kinase 96 1e-19
At1g12680 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 96 1e-19
7292679 [G] KOG0599 Phosphorylase kinase gamma subunit 96 1e-19
Hs4505195 [T] KOG0192 Tyrosine kinase specific for activated (GT... 96 2e-19
Hs14670383 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase ... 96 2e-19
CE17523 [T] KOG0194 Protein tyrosine kinase 96 2e-19
CE06991 [T] KOG0194 Protein tyrosine kinase 96 2e-19
At5g24430 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 96 2e-19
At4g32830 [D] KOG0580 Serine/threonine protein kinase 96 2e-19
At4g14480 [T] KOG0582 Ste20-like serine/threonine protein kinase 96 2e-19
At2g41910 [T] KOG0198 MEKK and related serine/threonine protein ... 96 2e-19
At2g38490 [T] KOG0583 Serine/threonine protein kinase 96 2e-19
At2g25880 [D] KOG0580 Serine/threonine protein kinase 96 2e-19
SPCC74.03c [T] KOG0583 Serine/threonine protein kinase 96 3e-19
SPAC1D4.13 [T] KOG0581 Mitogen-activated protein kinase kinase (... 96 3e-19
Hs4759052 [T] KOG0603 Ribosomal protein S6 kinase 96 3e-19
Hs4505569 [R] KOG0593 Predicted protein kinase KKIAMRE 96 3e-19
At3g46930 [T] KOG0192 Tyrosine kinase specific for activated (GT... 96 3e-19
At3g24550 [T] KOG1187 Serine/threonine protein kinase 96 3e-19
At2g41860 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 96 3e-19
At2g34290 [T] KOG0198 MEKK and related serine/threonine protein ... 96 3e-19
At1g08720 [T] KOG0192 Tyrosine kinase specific for activated (GT... 96 3e-19
7290249 [R] KOG0586 Serine/threonine protein kinase 96 3e-19
ECU03g0620 [D] KOG0590 Checkpoint kinase and related serine/thre... 95 3e-19
CE28061 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-... 95 3e-19
CE28060 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-... 95 3e-19
CE28059 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-... 95 3e-19
CE28058 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-... 95 3e-19
CE28057 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-... 95 3e-19
CE28056 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-... 95 3e-19
CE28055 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-... 95 3e-19
CE28054 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-... 95 3e-19
CE28053 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-... 95 3e-19
CE28051 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-... 95 3e-19
CE06563 [T] KOG0194 Protein tyrosine kinase 95 3e-19
At2g41930 [T] KOG0198 MEKK and related serine/threonine protein ... 95 3e-19
SPBC11B10.09 [R] KOG0594 Protein kinase PCTAIRE and related kinases 95 4e-19
Hs4506073 [T] KOG0694 Serine/threonine protein kinase 95 4e-19
Hs22065797 [T] KOG0577 Serine/threonine protein kinase 95 4e-19
Hs21361643 [T] KOG4717 Serine/threonine protein kinase 95 4e-19
Hs14758219 [T] KOG0694 Serine/threonine protein kinase 95 4e-19
Hs14249562 [TR] KOG0606 Microtubule-associated serine/threonine ... 95 4e-19
CE03609 [T] KOG0194 Protein tyrosine kinase 95 4e-19
At5g57630 [T] KOG0583 Serine/threonine protein kinase 95 4e-19
Hs5902140_2 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase... 95 4e-19
At1g79570_2 [T] KOG0192 Tyrosine kinase specific for activated (... 95 4e-19
Hs7706059 [R] KOG0593 Predicted protein kinase KKIAMRE 94 6e-19
Hs5453978 [T] KOG0614 cGMP-dependent protein kinase 94 6e-19
Hs10835242 [T] KOG0614 cGMP-dependent protein kinase 94 6e-19
At4g40010 [T] KOG0583 Serine/threonine protein kinase 94 6e-19
At3g57530 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 94 6e-19
7299438 [R] KOG0586 Serine/threonine protein kinase 94 6e-19
Hs20127541 [RT] KOG0598 Ribosomal protein S6 kinase and related ... 94 7e-19
Hs14754789 [OUT] KOG0595 Serine/threonine-protein kinase involve... 94 7e-19
At1g69790 [T] KOG1187 Serine/threonine protein kinase 94 7e-19
SPAC23C11.16 [D] KOG0575 Polo-like serine/threonine protein kinase 94 1e-18
CE29092 [T] KOG0694 Serine/threonine protein kinase 94 1e-18
At5g20930 [T] KOG1151 Tousled-like protein kinase 94 1e-18
At5g11850 [T] KOG0192 Tyrosine kinase specific for activated (GT... 94 1e-18
7303915 [T] KOG0694 Serine/threonine protein kinase 94 1e-18
7303914 [T] KOG0694 Serine/threonine protein kinase 94 1e-18
At1g16270_2 [T] KOG0192 Tyrosine kinase specific for activated (... 94 1e-18
SPBC32H8.10 [D] KOG0600 Cdc2-related protein kinase 93 1e-18
Hs4506739 [RT] KOG0598 Ribosomal protein S6 kinase and related p... 93 1e-18
Hs4505055 [T] KOG0197 Tyrosine kinases 93 1e-18
Hs4502557 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 93 1e-18
Hs20428652 [T] KOG0197 Tyrosine kinases 93 1e-18
Hs16950621 [Z] KOG0613 Projectin/twitchin and related proteins 93 1e-18
Hs16950613 [Z] KOG0613 Projectin/twitchin and related proteins 93 1e-18
Hs16950611 [Z] KOG0613 Projectin/twitchin and related proteins 93 1e-18
Hs16950601 [Z] KOG0613 Projectin/twitchin and related proteins 93 1e-18
CE06119 [T] KOG0194 Protein tyrosine kinase 93 1e-18
At5g63650 [T] KOG0583 Serine/threonine protein kinase 93 1e-18
At3g24720 [T] KOG0192 Tyrosine kinase specific for activated (GT... 93 1e-18
At3g20410 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 93 1e-18
YGL158w [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-... 93 2e-18
SPCC1259.13 [D] KOG0590 Checkpoint kinase and related serine/thr... 93 2e-18
At3g51630 [R] KOG0584 Serine/threonine protein kinase 93 2e-18
At3g24400 [T] KOG1187 Serine/threonine protein kinase 93 2e-18
At2g31010 [T] KOG0192 Tyrosine kinase specific for activated (GT... 93 2e-18
7303211 [T] KOG4717 Serine/threonine protein kinase 93 2e-18
7294770 [T] KOG0603 Ribosomal protein S6 kinase 93 2e-18
At1g64630_2 [R] KOG0584 Serine/threonine protein kinase 93 2e-18
Hs4504357 [T] KOG0197 Tyrosine kinases 92 2e-18
Hs20550407 [T] KOG0201 Serine/threonine protein kinase 92 2e-18
Hs20545357 [T] KOG0583 Serine/threonine protein kinase 92 2e-18
>YLR362w [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 717
Score = 779 bits (2012), Expect = 0.0
Identities = 427/742 (57%), Positives = 519/742 (69%), Gaps = 72/742 (9%)
Query: 10 SEVPFVEKFLGEVECEEYLPTFEKFRLFDEDRLYYLDREILEELGVKKIGDKIKILKQSR 69
+++PFV+ FL E+ C +YL +F + L E+ + YLD++IL LGV KIGD++KIL++S+
Sbjct: 20 NDLPFVQLFLEEIGCTQYLDSFIQCNLVTEEEIKYLDKDILIALGVNKIGDRLKILRKSK 79
Query: 70 QLRRDA--SGFNPKKELVEITAKINALNSNPLSINEELVTDKHSVIFILNDGSAKKVNVN 127
+RD N K L+E K+++L++ LS+N EL+ +KH VIFILNDGSAKKVNVN
Sbjct: 80 SFQRDKRIEQVNRLKNLME---KVSSLSTATLSMNSELIPEKHCVIFILNDGSAKKVNVN 136
Query: 128 GCFNAHSIKKKLIKRLPSEFISIDPVTKEATHSSQDYDVFVVDYVKNVLHLLYDVELVTI 187
GCFNA SIKK+LI+RLP E ++ + E T QDYDVFV+DY KNVLHLLYDVELVTI
Sbjct: 137 GCFNADSIKKRLIRRLPHELLATNS-NGEVTKMVQDYDVFVLDYTKNVLHLLYDVELVTI 195
Query: 188 CHSSDRLEKNRLIFVSKDQTPSEKAIFTSKKVYLKTLSVMQQMGSQPGAGRPLLSGPGTN 247
CH++DR+EKNRLIFVSKDQTPS+KAI TSKK+YL+TLS + Q+G P + L G +
Sbjct: 196 CHANDRVEKNRLIFVSKDQTPSDKAISTSKKLYLRTLSALSQVG--PSSSNLLAQNKGIS 253
Query: 248 ------ALRIEN-RSDNIREIFTQRPPTELISTNLPEYFPHTDINRLKKTLRNSMRQSIR 300
LRI+N D IR+IF QRPP+E ISTNL YFPHTD+ RL+KT+R S R S R
Sbjct: 254 HNNAEGKLRIDNTEKDRIRQIFNQRPPSEFISTNLAGYFPHTDMKRLQKTMRESFRHSAR 313
Query: 301 ASMIRGKNGSLVSLAGSNKIGDILVNQSHAVDRALLESIQNDGSASNSADHAVP-MHNTS 359
S+ + + S A SN IGDIL+ S+AVD ALL+ + +S +P + +
Sbjct: 314 LSIAQRRPLS----AESNNIGDILLKHSNAVDMALLQGLDQTRLSSKLDTTKIPKLAHKR 369
Query: 360 TNGSDASTASLTPLMKRTXXXXXXXXXXXXXXXXXXXXXXXXXXXDKIELYSXXXXXXXX 419
+DA + L + + + S
Sbjct: 370 PEDNDAISNQL----------------------------------ELLSVESGEEEDHDF 395
Query: 420 XXXXXXXISLPTKVEAPKSWLKGARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTA 479
+SLPTK+ PK+WLKGA IGSGSFGSVYLGMNA TGELMAVKQVE+K +
Sbjct: 396 FGEDSDIVSLPTKIATPKNWLKGACIGSGSFGSVYLGMNAHTGELMAVKQVEIKNNNI-- 453
Query: 480 GVVSIADESKKAHSPG--------------GGNTAVKNTSQIHRKMIDALQHEMNILKEL 525
GV + D +K+A+S G + K IHRKM+DALQHEMN+LKEL
Sbjct: 454 GVPT--DNNKQANSDENNEQEEQQEKIEDVGAVSHPKTNQNIHRKMVDALQHEMNLLKEL 511
Query: 526 HHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNYGPFDEPLVKNFTRQILIGLAYLH 585
HHENIVTYYG+SQEGGNLNIFLEYVPGGSVSSMLNNYGPF+E L+ NFTRQILIG+AYLH
Sbjct: 512 HHENIVTYYGASQEGGNLNIFLEYVPGGSVSSMLNNYGPFEESLITNFTRQILIGVAYLH 571
Query: 586 KRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPLNKQQNKRASLQGSVYWMAPEVVKQ 645
K+NIIHRDIKGANILIDIKG VKITDFGISKKLSPLNK+QNKRASLQGSV+WM+PEVVKQ
Sbjct: 572 KKNIIHRDIKGANILIDIKGCVKITDFGISKKLSPLNKKQNKRASLQGSVFWMSPEVVKQ 631
Query: 646 VVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAIFKIGTNIIPEIPSWVSEEAKAFLFK 705
TT KADIWS GCV++EMFTGKHPFPDFSQMQAIFKIGTN PEIPSW + E K FL K
Sbjct: 632 TATTAKADIWSTGCVVIEMFTGKHPFPDFSQMQAIFKIGTNTTPEIPSWATSEGKNFLRK 691
Query: 706 SFELDYRKRPSSLGLLQEPWLN 727
+FELDY+ RPS+L LLQ PWL+
Sbjct: 692 AFELDYQYRPSALELLQHPWLD 713
>SPBC1D7.05c [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 362
Score = 301 bits (770), Expect = 3e-81
Identities = 158/292 (54%), Positives = 198/292 (67%), Gaps = 29/292 (9%)
Query: 439 WLKGARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGN 498
W++GA IGSGSFG VYLGMNA +GELMAVKQV ++ ESK H+
Sbjct: 97 WIRGALIGSGSFGQVYLGMNASSGELMAVKQV----------ILDSVSESKDRHA----- 141
Query: 499 TAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSM 558
K++DAL E+ +L+EL HE+IV Y GS+ +LNIFLEYVPGGSV+ +
Sbjct: 142 -----------KLLDALAGEIALLQELSHEHIVQYLGSNLNSDHLNIFLEYVPGGSVAGL 190
Query: 559 LNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKL 618
L YG F+E LVKNF +Q L GL YLH R I+HRDIKGANIL+D KG +KI+DFGISKKL
Sbjct: 191 LTMYGSFEETLVKNFIKQTLKGLEYLHSRGIVHRDIKGANILVDNKGKIKISDFGISKKL 250
Query: 619 ---SPLNKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFS 675
S K R S QGS +WMAPEVVKQ + TEK DIWS+GC+++EM T KHP+P+
Sbjct: 251 ELNSTSTKTGGARPSFQGSSFWMAPEVVKQTMHTEKTDIWSLGCLVIEMLTSKHPYPNCD 310
Query: 676 QMQAIFKIGTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWLN 727
QMQAIF+IG NI+PE PS +S A FL K+F +D RP++ LL P+++
Sbjct: 311 QMQAIFRIGENILPEFPSNISSSAIDFLEKTFAIDCNLRPTASELLSHPFVS 362
>At1g09000 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 666
Score = 242 bits (617), Expect = 2e-63
Identities = 133/293 (45%), Positives = 182/293 (61%), Gaps = 29/293 (9%)
Query: 436 PKSWLKGARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPG 495
P SW KG IG G+FG+VY+GMN ++GEL+AVKQV +
Sbjct: 66 PISWRKGQLIGRGAFGTVYMGMNLDSGELLAVKQVLI----------------------- 102
Query: 496 GGNTAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSV 555
N A K +Q H I L+ E+ +LK L H NIV Y G+ +E LNI LE+VPGGS+
Sbjct: 103 AANFASKEKTQAH---IQELEEEVKLLKNLSHPNIVRYLGTVREDDTLNILLEFVPGGSI 159
Query: 556 SSMLNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGIS 615
SS+L +GPF E +V+ +TRQ+L+GL YLH I+HRDIKGANIL+D KG +K+ DFG S
Sbjct: 160 SSLLEKFGPFPESVVRTYTRQLLLGLEYLHNHAIMHRDIKGANILVDNKGCIKLADFGAS 219
Query: 616 KKLSPLNKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPF-PDF 674
K+++ L + S++G+ YWMAPEV+ Q + ADIWSVGC ++EM TGK P+ +
Sbjct: 220 KQVAELATMTGAK-SMKGTPYWMAPEVILQTGHSFSADIWSVGCTVIEMVTGKAPWSQQY 278
Query: 675 SQMQAIFKIG-TNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
++ AIF IG T P IP +S +AK FL K + RP++ LL+ P++
Sbjct: 279 KEVAAIFFIGTTKSHPPIPDTLSSDAKDFLLKCLQEVPNLRPTASELLKHPFV 331
>At3g06030 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 651
Score = 238 bits (607), Expect = 2e-62
Identities = 134/300 (44%), Positives = 183/300 (60%), Gaps = 30/300 (10%)
Query: 430 PTKVEAPK-SWLKGARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADES 488
P K EAP W KG IG G+FG VY+GMN ++GEL+A+KQV + P++
Sbjct: 58 PRKEEAPSIRWRKGELIGCGAFGRVYMGMNLDSGELLAIKQVLIAPSS------------ 105
Query: 489 KKAHSPGGGNTAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLE 548
A K +Q H I L+ E+ +LK L H NIV Y G+ +E +LNI +E
Sbjct: 106 -----------ASKEKTQGH---IRELEEEVQLLKNLSHPNIVRYLGTVRESDSLNILME 151
Query: 549 YVPGGSVSSMLNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVK 608
+VPGGS+SS+L +G F EP++ +T+Q+L+GL YLH I+HRDIKGANIL+D KG ++
Sbjct: 152 FVPGGSISSLLEKFGSFPEPVIIMYTKQLLLGLEYLHNNGIMHRDIKGANILVDNKGCIR 211
Query: 609 ITDFGISKKLSPLNKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGK 668
+ DFG SKK+ L N S++G+ YWMAPEV+ Q + ADIWSVGC ++EM TGK
Sbjct: 212 LADFGASKKVVEL-ATVNGAKSMKGTPYWMAPEVILQTGHSFSADIWSVGCTVIEMATGK 270
Query: 669 HPFPD-FSQMQAIFKIG-TNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
P+ + + Q A+ IG T P IP +S EAK FL K + R S+ LLQ P++
Sbjct: 271 PPWSEQYQQFAAVLHIGRTKAHPPIPEDLSPEAKDFLMKCLHKEPSLRLSATELLQHPFV 330
>At1g54960 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 585
Score = 234 bits (598), Expect = 3e-61
Identities = 128/296 (43%), Positives = 180/296 (60%), Gaps = 29/296 (9%)
Query: 432 KVEAPKSWLKGARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKA 491
+++ P W KG IG G+FG+VY+GMN ++GEL+AVKQV +
Sbjct: 61 QIKPPIRWRKGQLIGRGAFGTVYMGMNLDSGELLAVKQVLIT------------------ 102
Query: 492 HSPGGGNTAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVP 551
N A K +Q H I L+ E+ +LK L H NIV Y G+ +E LNI LE+VP
Sbjct: 103 -----SNCASKEKTQAH---IQELEEEVKLLKNLSHPNIVRYLGTVREDETLNILLEFVP 154
Query: 552 GGSVSSMLNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITD 611
GGS+SS+L +G F E +V+ +T Q+L+GL YLH I+HRDIKGANIL+D +G +K+ D
Sbjct: 155 GGSISSLLEKFGAFPESVVRTYTNQLLLGLEYLHNHAIMHRDIKGANILVDNQGCIKLAD 214
Query: 612 FGISKKLSPLNKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPF 671
FG SK+++ L + S++G+ YWMAPEV+ Q + ADIWSVGC ++EM TGK P+
Sbjct: 215 FGASKQVAELATISGAK-SMKGTPYWMAPEVILQTGHSFSADIWSVGCTVIEMVTGKAPW 273
Query: 672 -PDFSQMQAIFKIG-TNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPW 725
+ ++ AIF IG T P IP +S +A FL K + + RP++ LL+ W
Sbjct: 274 SQQYKEIAAIFHIGTTKSHPPIPDNISSDANDFLLKCLQQEPNLRPTASELLKVKW 329
>At1g53570 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 608
Score = 229 bits (583), Expect = 1e-59
Identities = 125/291 (42%), Positives = 177/291 (59%), Gaps = 35/291 (12%)
Query: 438 SWLKGARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGG 497
+W KG +GSG+FG VYLG N+E G++ A+K+V++ I+D+
Sbjct: 213 TWKKGKFLGSGTFGQVYLGFNSEKGKMCAIKEVKV-----------ISDD---------- 251
Query: 498 NTAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSS 557
Q ++ + L E+N+L +L H NIV YYGS L+++LEYV GGS+
Sbjct: 252 --------QTSKECLKQLNQEINLLNQLCHPNIVQYYGSELSEETLSVYLEYVSGGSIHK 303
Query: 558 MLNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKK 617
+L +YG F EP+++N+TRQIL GLAYLH RN +HRDIKGANIL+D G +K+ DFG++K
Sbjct: 304 LLKDYGSFTEPVIQNYTRQILAGLAYLHGRNTVHRDIKGANILVDPNGEIKLADFGMAKH 363
Query: 618 LSPLNKQQNKRASLQGSVYWMAPEVV-KQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQ 676
++ + S +GS YWMAPEVV Q T DIWS+GC I+EM T K P+ F
Sbjct: 364 VTAFSTM----LSFKGSPYWMAPEVVMSQNGYTHAVDIWSLGCTILEMATSKPPWSQFEG 419
Query: 677 MQAIFKIG-TNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
+ AIFKIG + PEIP +S +AK F+ + + RP++ LL+ P+L
Sbjct: 420 VAAIFKIGNSKDTPEIPDHLSNDAKNFIRLCLQRNPTVRPTASQLLEHPFL 470
>At1g63700 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 883
Score = 221 bits (564), Expect = 2e-57
Identities = 126/307 (41%), Positives = 178/307 (57%), Gaps = 39/307 (12%)
Query: 430 PTKVEAPKS----WLKGARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIA 485
P + EA S W KG +G GSFG VYLG N+E+GE+ A+K+V L +
Sbjct: 387 PARAEATVSPGSRWKKGRLLGMGSFGHVYLGFNSESGEMCAMKEVTL-----------CS 435
Query: 486 DESKKAHSPGGGNTAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNI 545
D+ K R+ L E+++L L H+NIV YYGS L I
Sbjct: 436 DDPKS------------------RESAQQLGQEISVLSRLRHQNIVQYYGSETVDDKLYI 477
Query: 546 FLEYVPGGSVSSMLNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKG 605
+LEYV GGS+ +L YG F E ++N+T+QIL GLAYLH +N +HRDIKGANIL+D G
Sbjct: 478 YLEYVSGGSIYKLLQEYGQFGENAIRNYTQQILSGLAYLHAKNTVHRDIKGANILVDPHG 537
Query: 606 GVKITDFGISKKLSPLNKQQNKRASLQGSVYWMAPEVVKQVVTTEKA-DIWSVGCVIVEM 664
VK+ DFG++K ++ Q+ S +GS YWMAPEV+K + A DIWS+GC ++EM
Sbjct: 538 RVKVADFGMAKHIT----AQSGPLSFKGSPYWMAPEVIKNSNGSNLAVDIWSLGCTVLEM 593
Query: 665 FTGKHPFPDFSQMQAIFKIG-TNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQE 723
T K P+ + + A+FKIG + +P+IP +SEE K F+ K + + RP++ LL
Sbjct: 594 ATTKPPWSQYEGVPAMFKIGNSKELPDIPDHLSEEGKDFVRKCLQRNPANRPTAAQLLDH 653
Query: 724 PWLNTVL 730
++ V+
Sbjct: 654 AFVRNVM 660
>YJL095w [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 1478
Score = 220 bits (561), Expect = 5e-57
Identities = 125/295 (42%), Positives = 180/295 (60%), Gaps = 36/295 (12%)
Query: 438 SWLKGARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGG 497
+W+KG IG GSFG+VYL +N TGE+MAVKQVE+ +
Sbjct: 1174 AWMKGEMIGKGSFGAVYLCLNVTTGEMMAVKQVEVPKYS-------------------SQ 1214
Query: 498 NTAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSS 557
N A+ +T ++AL+ E++ LK+L H NIV Y G + ++FLEYV GGSV S
Sbjct: 1215 NEAILST-------VEALRSEVSTLKDLDHLNIVQYLGFENKNNIYSLFLEYVAGGSVGS 1267
Query: 558 MLNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKK 617
++ YG FDEPL+K+ T Q+L GLAYLH + I+HRD+K N+L+D G KI+DFGIS+K
Sbjct: 1268 LIRMYGRFDEPLIKHLTTQVLKGLAYLHSKGILHRDMKADNLLLDQDGICKISDFGISRK 1327
Query: 618 LSPLNKQQNKRASLQGSVYWMAPEVV--KQVVTTEKADIWSVGCVIVEMFTGKHPFPDFS 675
+ N +++G+V+WMAPE+V KQ + K DIWS+GC+++EMF GK P+ +
Sbjct: 1328 SKDI--YSNSDMTMRGTVFWMAPEMVDTKQGYSA-KVDIWSLGCIVLEMFAGKRPWSNLE 1384
Query: 676 QMQAIFKIG-TNIIPEIPS----WVSEEAKAFLFKSFELDYRKRPSSLGLLQEPW 725
+ A+FKIG + P IP +S+ + FL FE++ KRP++ LL P+
Sbjct: 1385 VVAAMFKIGKSKSAPPIPEDTLPLISQIGRNFLDACFEINPEKRPTANELLSHPF 1439
>SPAC1F3.02c [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 1116
Score = 216 bits (550), Expect = 1e-55
Identities = 121/295 (41%), Positives = 176/295 (59%), Gaps = 32/295 (10%)
Query: 439 WLKGARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGN 498
W+KG IG+G++G V+L MN TGEL+AVKQVE+ T G +
Sbjct: 825 WMKGELIGNGTYGKVFLAMNINTGELIAVKQVEIPQTI------------------NGRH 866
Query: 499 TAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSM 558
Q+ + ++D++ E++++ +L H NIV Y G + +++IFLEYV GGS+
Sbjct: 867 ------DQLRKDIVDSINAEISMIADLDHLNIVQYLGFEKTETDISIFLEYVSGGSIGRC 920
Query: 559 LNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKL 618
L NYGPF+E LV+ +RQ+L GL+YLH + IIHRD+K N+LID G KI+DFGISK
Sbjct: 921 LRNYGPFEEQLVRFVSRQVLYGLSYLHSKGIIHRDLKADNLLIDFDGVCKISDFGISKH- 979
Query: 619 SPLNKQQNKRASLQGSVYWMAPEVV--KQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQ 676
S + S+QGS++WMAPEV+ + K D+WS+GCV++EM G+ P+
Sbjct: 980 SDNVYDNDANLSMQGSIFWMAPEVIHNDHQGYSAKVDVWSLGCVVLEMLAGRRPWSTDEA 1039
Query: 677 MQAIFKIGTN-----IIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
+QA+FK+GT I E+ S VS EA FL F ++ RP++ LL P++
Sbjct: 1040 IQAMFKLGTEKKAPPIPSELVSQVSPEAIQFLNACFTVNADVRPTAEELLNHPFM 1094
>Hs4505153 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 626
Score = 212 bits (540), Expect = 1e-54
Identities = 121/298 (40%), Positives = 168/298 (55%), Gaps = 34/298 (11%)
Query: 428 SLPTKV-EAPKSWLKGARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIAD 486
++PTK AP +W +G +G G+FG VYL + +TG +A KQV+ P +
Sbjct: 350 NVPTKSPSAPINWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETS------ 403
Query: 487 ESKKAHSPGGGNTAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGG--NLN 544
K + AL+ E+ +LK L HE IV YYG ++ L
Sbjct: 404 -----------------------KEVSALECEIQLLKNLQHERIVQYYGCLRDRAEKTLT 440
Query: 545 IFLEYVPGGSVSSMLNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIK 604
IF+EY+PGGSV L YG E + + +TRQIL G++YLH I+HRDIKGANIL D
Sbjct: 441 IFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSA 500
Query: 605 GGVKITDFGISKKLSPLNKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEM 664
G VK+ DFG SK+L + S+ G+ YWM+PEV+ KAD+WS+GC +VEM
Sbjct: 501 GNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEM 560
Query: 665 FTGKHPFPDFSQMQAIFKIGTN-IIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLL 721
T K P+ ++ M AIFKI T P++PS +SE + FL + F ++ R+RPS+ LL
Sbjct: 561 LTEKPPWAEYEAMAAIFKIATQPTNPQLPSHISEHGRDFLRRIF-VEARQRPSAEELL 617
>At5g66850 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 376
Score = 207 bits (526), Expect = 6e-53
Identities = 124/301 (41%), Positives = 170/301 (56%), Gaps = 43/301 (14%)
Query: 439 WLKGARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGN 498
W KG IG G+FGSVY+ N+ETG L A+K+VEL P D+ K A
Sbjct: 5 WKKGKLIGRGTFGSVYVASNSETGALCAMKEVELFP-----------DDPKSA------- 46
Query: 499 TAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSM 558
+ I L+ E+ +L L H NIV Y+GS I+LEYV GS++
Sbjct: 47 -----------ECIKQLEQEIKLLSNLQHPNIVQYFGSETVEDRFFIYLEYVHPGSINKY 95
Query: 559 LNNY-GPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKK 617
+ ++ G E +V+NFTR IL GLAYLH + +HRDIKGAN+L+D G VK+ DFG++K
Sbjct: 96 IRDHCGTMTESVVRNFTRHILSGLAYLHNKKTVHRDIKGANLLVDASGVVKLADFGMAKH 155
Query: 618 LSPLNKQQNKRASLQGSVYWMAPEVVKQVVTTEKA--------DIWSVGCVIVEMFTGKH 669
L+ Q SL+GS YWMAPEV+ Q V + + DIWS+GC I+EMFTGK
Sbjct: 156 LT----GQRADLSLKGSPYWMAPEVLMQAVMQKDSNPDLAFAVDIWSLGCTIIEMFTGKP 211
Query: 670 PFPDFSQMQAIFKIGTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWLNTV 729
P+ +F A+FK+ + P IP +S E K FL F+ + +RP++ LL+ +L
Sbjct: 212 PWSEFEGAAAMFKVMRD-SPPIPESMSPEGKDFLRLCFQRNPAERPTASMLLEHRFLKNS 270
Query: 730 L 730
L
Sbjct: 271 L 271
>HsM5729922 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 618
Score = 199 bits (506), Expect = 1e-50
Identities = 120/305 (39%), Positives = 167/305 (54%), Gaps = 34/305 (11%)
Query: 427 ISLPTKV-EAPKSWLKGARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIA 485
IS P++ AP +W G +G G+FG VYL + +TG +AVKQV+ P +
Sbjct: 342 ISPPSRSPRAPTNWRLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETS----- 396
Query: 486 DESKKAHSPGGGNTAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYG--SSQEGGNL 543
K ++AL+ E+ +LK HE IV YYG + L
Sbjct: 397 ------------------------KEVNALECEIQLLKNFLHERIVQYYGCLRDPQEKTL 432
Query: 544 NIFLEYVPGGSVSSMLNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDI 603
+IF+EY+PGGS+ L YG E + +TRQIL G+ YLH I+HRDIKGANIL D
Sbjct: 433 SIFMEYMPGGSIKDQLKAYGALTENGTRKYTRQILEGVHYLHSNMILHRDIKGANILRDS 492
Query: 604 KGGVKITDFGISKKLSPLNKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVE 663
G VK+ DFG SK+L + S+ G+ YWM+PEV+ KADIWSV C +VE
Sbjct: 493 TGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISGQGYGRKADIWSVACTVVE 552
Query: 664 MFTGKHPFPDFSQMQAIFKIGTN-IIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQ 722
M T K P+ +F M AIFKI T P++P VS+ + FL + F ++ + RPS+ LL+
Sbjct: 553 MLTEKPPWAEFEAMAAIFKIATQPTNPKLPPHVSDYTRDFLKRIF-VEAKLRPSADELLR 611
Query: 723 EPWLN 727
+++
Sbjct: 612 HMFVH 616
>At3g13530 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 1368
Score = 199 bits (506), Expect = 1e-50
Identities = 109/290 (37%), Positives = 167/290 (57%), Gaps = 37/290 (12%)
Query: 439 WLKGARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGN 498
++ G IG G++G VY G++ E G+ +A+KQV L+
Sbjct: 20 YMLGDEIGKGAYGRVYKGLDLENGDFVAIKQVSLE------------------------- 54
Query: 499 TAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSM 558
I ++ ++ + E+++LK L+H+NIV Y GSS+ +L+I LEYV GS++++
Sbjct: 55 -------NIVQEDLNTIMQEIDLLKNLNHKNIVKYLGSSKTKTHLHIILEYVENGSLANI 107
Query: 559 L--NNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISK 616
+ N +GPF E LV + Q+L GL YLH++ +IHRDIKGANIL +G VK+ DFG++
Sbjct: 108 IKPNKFGPFPESLVAVYIAQVLEGLVYLHEQGVIHRDIKGANILTTKEGLVKLADFGVAT 167
Query: 617 KLSPLNKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQ 676
KL N+ S+ G+ YWMAPEV++ +DIWSVGC ++E+ T P+ D
Sbjct: 168 KL---NEADVNTHSVVGTPYWMAPEVIEMSGVCAASDIWSVGCTVIELLTCVPPYYDLQP 224
Query: 677 MQAIFKIGTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
M A+F+I + P IP +S + FL + F+ D R+RP + LL PW+
Sbjct: 225 MPALFRIVQDDNPPIPDSLSPDITDFLRQCFKKDSRQRPDAKTLLSHPWI 274
>Hs21735556 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 620
Score = 199 bits (505), Expect = 2e-50
Identities = 120/305 (39%), Positives = 168/305 (54%), Gaps = 34/305 (11%)
Query: 427 ISLPTKV-EAPKSWLKGARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIA 485
IS P++ AP +W G +G G+FG VYL + +TG +AVKQV+ P +
Sbjct: 344 ISPPSRSPRAPTNWRLGKLLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETS----- 398
Query: 486 DESKKAHSPGGGNTAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYG--SSQEGGNL 543
K ++AL+ E+ +LK L HE IV YYG + L
Sbjct: 399 ------------------------KEVNALECEIQLLKNLLHERIVQYYGCLRDPQEKTL 434
Query: 544 NIFLEYVPGGSVSSMLNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDI 603
+IF+EY+PGGS+ L YG E + + +TRQIL G+ YLH I+ RDIKGANIL D
Sbjct: 435 SIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYLHSNMIVLRDIKGANILRDS 494
Query: 604 KGGVKITDFGISKKLSPLNKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVE 663
G VK+ DFG SK+L + S+ G+ YWM+PEV+ KADIWSV C +VE
Sbjct: 495 TGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISGEGYGRKADIWSVACTVVE 554
Query: 664 MFTGKHPFPDFSQMQAIFKIGTN-IIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQ 722
M T K P+ +F M AIFKI T P++P VS+ + FL + F ++ + RPS+ LL+
Sbjct: 555 MLTEKPPWAEFEAMAAIFKIATQPTNPKLPPHVSDYTRDFLKRIF-VEAKLRPSADELLR 613
Query: 723 EPWLN 727
+++
Sbjct: 614 HMFVH 618
>At4g08500 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 608
Score = 197 bits (501), Expect = 5e-50
Identities = 113/296 (38%), Positives = 171/296 (57%), Gaps = 39/296 (13%)
Query: 438 SWLKGARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGG 497
SW KG +G GSFGSVY G++ + G+ AVK+V S+ D+ +A
Sbjct: 332 SWQKGQLLGRGSFGSVYEGISGD-GDFFAVKEV------------SLLDQGSQA------ 372
Query: 498 NTAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSS 557
++ I L+ E+ +L +L H+NIV Y G++++G NL IFLE V GS+
Sbjct: 373 -----------QECIQQLEGEIKLLSQLQHQNIVRYRGTAKDGSNLYIFLELVTQGSLLK 421
Query: 558 MLNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKK 617
+ Y D +V +TRQIL GL YLH + IHRDIK ANIL+D G VK+ DFG++K
Sbjct: 422 LYQRYQLRDS-VVSLYTRQILDGLKYLHDKGFIHRDIKCANILVDANGAVKLADFGLAKV 480
Query: 618 LSPLNKQQNKRASLQGSVYWMAPEVVKQVVTT---EKADIWSVGCVIVEMFTGKHPFPDF 674
+ N S +G+ +WMAPEV+ + + ADIWS+GC ++EM TG+ P+ D
Sbjct: 481 -----SKFNDIKSCKGTPFWMAPEVINRKDSDGYGSPADIWSLGCTVLEMCTGQIPYSDL 535
Query: 675 SQMQAIFKIGTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWLNTVL 730
+QA+F+IG +PE+P +S +A+ F+ K +++ +RP++ LL P++ L
Sbjct: 536 EPVQALFRIGRGTLPEVPDTLSLDARLFILKCLKVNPEERPTAAELLNHPFVRRPL 591
>At3g07980 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 1367
Score = 197 bits (500), Expect = 6e-50
Identities = 108/290 (37%), Positives = 166/290 (57%), Gaps = 37/290 (12%)
Query: 439 WLKGARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGN 498
++ G IG G++G VY+G++ E G+ +A+KQV L+
Sbjct: 20 YMLGDEIGKGAYGRVYIGLDLENGDFVAIKQVSLE------------------------- 54
Query: 499 TAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSM 558
I ++ ++ + E+++LK L+H+NIV Y GS + +L+I LEYV GS++++
Sbjct: 55 -------NIGQEDLNTIMQEIDLLKNLNHKNIVKYLGSLKTKTHLHIILEYVENGSLANI 107
Query: 559 L--NNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISK 616
+ N +GPF E LV + Q+L GL YLH++ +IHRDIKGANIL +G VK+ DFG++
Sbjct: 108 IKPNKFGPFPESLVTVYIAQVLEGLVYLHEQGVIHRDIKGANILTTKEGLVKLADFGVAT 167
Query: 617 KLSPLNKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQ 676
KL N+ S+ G+ YWMAPEV++ +DIWSVGC I+E+ T P+ D
Sbjct: 168 KL---NEADFNTHSVVGTPYWMAPEVIELSGVCAASDIWSVGCTIIELLTCVPPYYDLQP 224
Query: 677 MQAIFKIGTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
M A+++I + P IP +S + FL F+ D R+RP + LL PW+
Sbjct: 225 MPALYRIVQDDTPPIPDSLSPDITDFLRLCFKKDSRQRPDAKTLLSHPWI 274
>SPBC21.06c [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 1062
Score = 196 bits (497), Expect = 1e-49
Identities = 108/285 (37%), Positives = 159/285 (54%), Gaps = 37/285 (12%)
Query: 442 GARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAV 501
G +G G+FG+VY G+N + GE +AVK+V+L
Sbjct: 12 GDCLGKGAFGAVYRGLNIKNGETVAVKKVKL----------------------------- 42
Query: 502 KNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNN 561
S++ + + ++ E+++LK L H NIV Y GS Q +L I LEY GS+ S+ N
Sbjct: 43 ---SKMLKSDLSVIKMEIDLLKNLDHPNIVKYRGSYQTNDSLCIILEYCENGSLRSICKN 99
Query: 562 YGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPL 621
+G E LV +T Q+L GL YLH + +IHRDIKGANIL G +K+ DFG++ K++ L
Sbjct: 100 FGKIPENLVALYTFQVLQGLLYLHNQGVIHRDIKGANILTTKDGTIKLADFGVATKINAL 159
Query: 622 NKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAIF 681
S+ GS YWMAPEV++ V T +DIWSVGC ++E+ G P+ D A+F
Sbjct: 160 EDH-----SVVGSPYWMAPEVIELVGATTASDIWSVGCTVIELLDGNPPYYDLDPTSALF 214
Query: 682 KIGTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
++ + P +PS +S AK+FL + F+ D R + LL+ PW+
Sbjct: 215 RMVKDEHPPLPSNISSAAKSFLMQCFQKDPNLRIKTRKLLKHPWV 259
>Hs22050308_2 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 291
Score = 186 bits (471), Expect = 1e-46
Identities = 112/310 (36%), Positives = 166/310 (53%), Gaps = 40/310 (12%)
Query: 431 TKVEAP----KSWLKGARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIAD 486
TK + P WLKG +IG G+F S Y + TG LMAVKQV
Sbjct: 8 TKAKQPYREDTEWLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQV---------------- 51
Query: 487 ESKKAHSPGGGNTAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIF 546
T V+NTS ++++AL+ E+ ++ L+H NI+ G++ E N N+F
Sbjct: 52 ------------TYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIRMLGATCEKSNYNLF 99
Query: 547 LEYVPGGSVSSMLNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKG- 605
+E++ GGSV+ +L+ YG F E +V N+T Q+L GL+YLH+ IIHRD+KGAN+LID G
Sbjct: 100 IEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLIDSTGQ 159
Query: 606 GVKITDFGISKKLSPLNKQQNK-RASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEM 664
++I DFG + +L+ + + L G++ +MAPEV++ D+WSVGC I+EM
Sbjct: 160 RLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSCDVWSVGCAIIEM 219
Query: 665 FTGKHPF---PDFSQMQAIFKI---GTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSL 718
K P+ + + IFK+ P IPS +S + + EL + RP S
Sbjct: 220 ACAKPPWNAEKHSNHLALIFKVIIASATTAPSIPSHLSPGLRDVALRCLELQPQDRPPSR 279
Query: 719 GLLQEPWLNT 728
LL+ P T
Sbjct: 280 ELLKHPVFRT 289
>At4g08480 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 773
Score = 184 bits (468), Expect = 3e-46
Identities = 109/296 (36%), Positives = 169/296 (56%), Gaps = 39/296 (13%)
Query: 438 SWLKGARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGG 497
SW KG + GSFGSVY ++ E G+ AVK+V S+ D+ +A
Sbjct: 500 SWQKGQLLRQGSFGSVYEAIS-EDGDFFAVKEV------------SLLDQGSQA------ 540
Query: 498 NTAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSS 557
++ I L+ E+ +L +L H+NI+ Y G+ ++G NL IFLE V GS+
Sbjct: 541 -----------QECIQQLEGEIALLSQLEHQNILRYRGTDKDGSNLYIFLELVTQGSLLE 589
Query: 558 MLNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKK 617
+ Y D L+ +T+QIL GL YLH + IHRDIK A IL+D G VK+ DFG++K
Sbjct: 590 LYRRYQIRDS-LISLYTKQILDGLKYLHHKGFIHRDIKCATILVDANGTVKLADFGLAK- 647
Query: 618 LSPLNKQQNKRASLQGSVYWMAPEVVKQVVTT---EKADIWSVGCVIVEMFTGKHPFPDF 674
+S LN ++++ +L +WMAPEV+ + ADIWS+GC ++EM TG+ P+ D
Sbjct: 648 VSKLNDIKSRKETL----FWMAPEVINRKDNDGYRSPADIWSLGCTVLEMCTGQIPYSDL 703
Query: 675 SQMQAIFKIGTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWLNTVL 730
++A+F+I +PE+P +S +A+ F+ K +L+ +RP++ LL P++ L
Sbjct: 704 EPVEALFRIRRGTLPEVPDTLSLDARHFILKCLKLNPEERPTATELLNHPFVRRPL 759
>At4g08470 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 560
Score = 183 bits (465), Expect = 7e-46
Identities = 106/298 (35%), Positives = 164/298 (54%), Gaps = 39/298 (13%)
Query: 432 KVEAPKSWLKGARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKA 491
K E SWLKG +G GS+ SVY ++ E G+ AVK+V L + A
Sbjct: 296 KPEDITSWLKGQLLGRGSYASVYEAIS-EDGDFFAVKEVSLLDKGIQA------------ 342
Query: 492 HSPGGGNTAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVP 551
++ I L+ E+ +L +L H+NIV Y G++++ L IFLE V
Sbjct: 343 -----------------QECIQQLEGEIALLSQLQHQNIVRYRGTAKDVSKLYIFLELVT 385
Query: 552 GGSVSSMLNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITD 611
GSV + Y +V +TRQIL GL YLH + +HRDIK AN+L+D G VK+ D
Sbjct: 386 QGSVQKLYERY-QLSYTVVSLYTRQILAGLNYLHDKGFVHRDIKCANMLVDANGTVKLAD 444
Query: 612 FGISKKLSPLNKQQNKRASLQGSVYWMAPEVVKQVVTT---EKADIWSVGCVIVEMFTGK 668
FG+++ + N S +G+++WMAPEV+ + + ADIWS+GC ++EM TG+
Sbjct: 445 FGLAEA-----SKFNDIMSCKGTLFWMAPEVINRKDSDGNGSPADIWSLGCTVLEMCTGQ 499
Query: 669 HPFPDFSQMQAIFKIGTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
P+ D +QA FKIG +P++P +S +A+ F+ +++ +RP++ LL P++
Sbjct: 500 IPYSDLKPIQAAFKIGRGTLPDVPDTLSLDARHFILTCLKVNPEERPTAAELLHHPFV 557
>SPAC9G1.02 [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and related
serine/threonine protein kinases
Length = 1401
Score = 176 bits (446), Expect = 1e-43
Identities = 105/303 (34%), Positives = 166/303 (54%), Gaps = 48/303 (15%)
Query: 439 WLKGARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGN 498
W +G + SG FG VY G+N ETG+L+AVK+++L+
Sbjct: 1037 WQQGHFVRSGMFGDVYTGVNMETGDLLAVKEIKLQ------------------------- 1071
Query: 499 TAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSM 558
S+ R +D + +EM +L+ L+H N+VTYYG + IF+E+ GGS++ +
Sbjct: 1072 -----DSRTFRSTVDQIHNEMTVLERLNHPNVVTYYGVEVHREKVYIFMEFCQGGSLADL 1126
Query: 559 LNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKL 618
L + DE ++K + Q+L GLAY+H ++I+HRDIK ANIL+D +G +K +DFG + +
Sbjct: 1127 LAHGRIEDENVLKVYVVQLLEGLAYIHSQHILHRDIKPANILLDHRGMIKYSDFGSALYV 1186
Query: 619 SPLNKQQNKRASLQ-------GSVYWMAPEVVKQVVTTEKA-----DIWSVGCVIVEMFT 666
SP + + +Q G+ +MAPE+ ++ T+K DIWS+GCVI+EM T
Sbjct: 1187 SPPTDPEVRYEDIQPELQHLAGTPMYMAPEI---ILGTKKGDFGAMDIWSLGCVILEMMT 1243
Query: 667 GKHPFPDFSQMQAI-FKIGTNIIPEIP--SWVSEEAKAFLFKSFELDYRKRPSSLGLLQE 723
G P+ + AI + + P IP +S A+ F+ + FE D +RP ++ LL
Sbjct: 1244 GSTPWSEMDNEWAIMYHVAAMHTPSIPQNEKISSLARDFIEQCFERDPEQRPRAVDLLTH 1303
Query: 724 PWL 726
PW+
Sbjct: 1304 PWI 1306
>Hs4758702 [T] KOG4279 Serine/threonine protein kinase
Length = 1011
Score = 172 bits (436), Expect = 2e-42
Identities = 100/235 (42%), Positives = 150/235 (63%), Gaps = 11/235 (4%)
Query: 500 AVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSML 559
A+K + + L E+ + + L H+NIV Y GS+ +GG L IF+E VPGGS+SS+L
Sbjct: 398 AIKEIPERDSRFSQPLHEEIALHRRLRHKNIVRYLGSASQGGYLKIFMEEVPGGSLSSLL 457
Query: 560 NN-YGPF--DEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILID-IKGGVKITDFGIS 615
+ +GP +E + +TRQIL GL YLH +I+HRDIKG N+LI+ G +KI+DFG S
Sbjct: 458 RSVWGPLKDNESTISFYTRQILQGLGYLHDNHIVHRDIKGDNVLINTFSGLLKISDFGTS 517
Query: 616 KKLSPLNKQQNKRASLQGSVYWMAPEVVKQVVT--TEKADIWSVGCVIVEMFTGKHPFPD 673
K+L+ + + G++ +MAPE++ Q + ADIWS+GC ++EM TG+ PF +
Sbjct: 518 KRLAGITPCTE---TFTGTLQYMAPEIIDQGPRGYGKAADIWSLGCTVIEMATGRPPFHE 574
Query: 674 FSQMQ-AIFKIGT-NIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
Q A+F++G + P +PS +S EA+AFL ++FE D R R S+ LL +P+L
Sbjct: 575 LGSPQAAMFQVGMYKVHPPMPSSLSAEAQAFLLRTFEPDPRLRASAQTLLGDPFL 629
>Hs5174547 [T] KOG4279 Serine/threonine protein kinase
Length = 1374
Score = 169 bits (429), Expect = 1e-41
Identities = 102/235 (43%), Positives = 146/235 (61%), Gaps = 11/235 (4%)
Query: 500 AVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSML 559
A+K + + L E+ + K L H+NIV Y GS E G + IF+E VPGGS+S++L
Sbjct: 707 AIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALL 766
Query: 560 -NNYGPF--DEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGV-KITDFGIS 615
+ +GP +E + +T+QIL GL YLH I+HRDIKG N+LI+ GV KI+DFG S
Sbjct: 767 RSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTS 826
Query: 616 KKLSPLNKQQNKRASLQGSVYWMAPEVVKQVVT--TEKADIWSVGCVIVEMFTGKHPFPD 673
K+L+ +N + G++ +MAPE++ + + ADIWS+GC I+EM TGK PF +
Sbjct: 827 KRLAGINPCTE---TFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYE 883
Query: 674 FSQMQ-AIFKIGT-NIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
+ Q A+FK+G + PEIP +S EAKAF+ K FE D KR + LL + +L
Sbjct: 884 LGEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACANDLLVDEFL 938
>At4g12020_6 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 422
Score = 168 bits (426), Expect = 2e-41
Identities = 104/298 (34%), Positives = 161/298 (53%), Gaps = 48/298 (16%)
Query: 439 WLKGARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGN 498
W KG +G GS GSVY G++A+ G+ A K+V S+ D+ +AH
Sbjct: 153 WQKGQLLGRGSLGSVYEGISAD-GDFFAFKEV------------SLLDQGSQAH------ 193
Query: 499 TAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSM 558
+ I ++ + +L +L H+NIV Y G++++ NL IFLE V GS+ +
Sbjct: 194 -----------EWIQQVEGGIALLSQLQHQNIVRYRGTTKDESNLYIFLELVTQGSLRKL 242
Query: 559 LNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKL 618
+ +V +TRQIL GL YLH + IHR+IK AN+L+D G VK+ DFG++K +
Sbjct: 243 YQR-NQLGDSVVSLYTRQILDGLKYLHDKGFIHRNIKCANVLVDANGTVKLADFGLAKVM 301
Query: 619 SPLNKQQNKRASLQGSVYW--MAPEVVKQVVTTE----KADIWSVGCVIVEMFTGKHPFP 672
S L + YW MAPEV+ + ADIWS+GC ++EM TG+ P+
Sbjct: 302 S-----------LWRTPYWNWMAPEVILNPKDYDGYGTPADIWSLGCTVLEMLTGQIPYS 350
Query: 673 DFSQMQAIFKIGTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWLNTVL 730
D A++ IGT +P+IP +S +A+ F+ +++ +RP++ LL P++N L
Sbjct: 351 DLEIGTALYNIGTGKLPKIPDILSLDARDFILTCLKVNPEERPTAAELLNHPFVNMPL 408
>7300559 [T] KOG4279 Serine/threonine protein kinase
Length = 1310
Score = 164 bits (416), Expect = 3e-40
Identities = 98/235 (41%), Positives = 142/235 (59%), Gaps = 11/235 (4%)
Query: 500 AVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSML 559
A+K + + + + L E+ + +L H NIV Y GS E G IF+E VPGGS+S +L
Sbjct: 606 AIKEVPEKNSQDVQPLHEEIKLHSQLRHRNIVRYLGSCSENGFFKIFMEQVPGGSLSDLL 665
Query: 560 -NNYGPF--DEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGG-VKITDFGIS 615
+GP +E + +++QIL GL YLH+++I+HRDIKG N+L++ G VKI+DFG S
Sbjct: 666 ETKWGPLKDNESTMAFYSKQILEGLKYLHEQDIVHRDIKGDNVLVNTYSGVVKISDFGTS 725
Query: 616 KKLSPLNKQQNKRASLQGSVYWMAPEVVKQVVT--TEKADIWSVGCVIVEMFTGKHPFPD 673
K+L+ +N + G++ +MAPEV+ Q V ADIWS GC VEM TGK PF +
Sbjct: 726 KRLARINPMTE---TFTGTLQYMAPEVIDQGVRGYGPAADIWSFGCTNVEMATGKPPFIE 782
Query: 674 F-SQMQAIFKIG-TNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
S A+FK+G P IP +S AK F+ + F + RPS+ LL++P+L
Sbjct: 783 LGSAHAAMFKVGFYKKHPNIPEELSANAKNFILRCFAISVMDRPSASQLLEDPFL 837
>7300435 [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and related
serine/threonine protein kinases
Length = 1612
Score = 164 bits (416), Expect = 3e-40
Identities = 100/289 (34%), Positives = 152/289 (51%), Gaps = 37/289 (12%)
Query: 439 WLKGARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGN 498
W +G +IG G FG VY +N TGELMA+K++ ++P G
Sbjct: 1323 WHRGIKIGQGRFGKVYTAVNNNTGELMAMKEIAIQP---------------------GET 1361
Query: 499 TAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSM 558
A+KN ++ E+ IL+ + H+N+V YYG L IF+E G++ S+
Sbjct: 1362 RALKNVAE-----------ELKILEGIKHKNLVRYYGIEVHREELLIFMELCSEGTLESL 1410
Query: 559 LNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANI-LIDIKGGVKITDFGISKK 617
+ G E L + FT Q+L G++ LHK I+HRDIK ANI L+D +K+ DFG + K
Sbjct: 1411 VELTGNLPEALTRRFTAQLLSGVSELHKHGIVHRDIKTANIFLVDGSNSLKLGDFGSAVK 1470
Query: 618 LSPLNKQQNKRASLQGSVYWMAPEVVKQVVTT---EKADIWSVGCVIVEMFTGKHPFPDF 674
+ + G+ +MAPEV + + ADIWSVGCV+VEM +GK P+ F
Sbjct: 1471 IQAHTTVPGELQGYVGTQAYMAPEVFTKTNSDGHGRAADIWSVGCVVVEMASGKRPWAQF 1530
Query: 675 -SQMQAIFKIGTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQ 722
S Q +FK+G P+ P +S+E F+ + D ++R +++ LL+
Sbjct: 1531 DSNFQIMFKVGMGEKPQAPESLSQEGHDFIDHCLQHDPKRRLTAVELLE 1579
>YCR073c [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and related
serine/threonine protein kinases
Length = 1331
Score = 162 bits (410), Expect = 2e-39
Identities = 95/307 (30%), Positives = 160/307 (51%), Gaps = 49/307 (15%)
Query: 439 WLKGARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGN 498
W K + IG G+FG VY +N E GE++AVK++++ T
Sbjct: 1034 WQKRSFIGGGTFGQVYSAINLENGEILAVKEIKIHDTTTM-------------------- 1073
Query: 499 TAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSM 558
+K+ ++ EM +L+ L+H NIV YYG +NIF+EY GGS++S+
Sbjct: 1074 ----------KKIFPLIKEEMTVLEMLNHPNIVQYYGVEVHRDKVNIFMEYCEGGSLASL 1123
Query: 559 LNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKL 618
L++ DE + + +T ++L GLAYLH+ ++HRDIK NIL+D G +K DFG ++ +
Sbjct: 1124 LDHGRIEDEMVTQVYTFELLEGLAYLHQSGVVHRDIKPENILLDFNGIIKYVDFGTARTV 1183
Query: 619 SPLNKQQNKRASLQ-------------GSVYWMAPEVVKQVVTTEKA---DIWSVGCVIV 662
+ + A++Q G+ +MAPE + K D+W++GCV++
Sbjct: 1184 VGSRTRTVRNAAVQDFGVETKSLNEMMGTPMYMAPETISGSAVKGKLGADDVWALGCVVL 1243
Query: 663 EMFTGKHPFPDFSQMQAI-FKIGTNIIPEIPS--WVSEEAKAFLFKSFELDYRKRPSSLG 719
EM TG+ P+ + AI + + IP++P+ ++ +AFL + D R +++
Sbjct: 1244 EMATGRRPWSNLDNEWAIMYHVAAGRIPQLPNRDEMTAAGRAFLERCLVQDPTMRATAVE 1303
Query: 720 LLQEPWL 726
LL +PW+
Sbjct: 1304 LLIDPWM 1310
>YNR031c [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and related
serine/threonine protein kinases
Length = 1579
Score = 160 bits (404), Expect = 8e-39
Identities = 100/323 (30%), Positives = 161/323 (48%), Gaps = 65/323 (20%)
Query: 439 WLKGARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGN 498
W K IG G+FG VY ++ + GE++AVK++ ++
Sbjct: 1266 WQKRNFIGGGTFGRVYSAVDLDNGEILAVKEINIQD------------------------ 1301
Query: 499 TAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSM 558
S+ +K+ ++ EM++L+ L+H NIV+YYG +NIF+EY GGS++++
Sbjct: 1302 ------SKSMQKIFPLIKEEMSVLEILNHPNIVSYYGVEVHRDKVNIFMEYCEGGSLAAL 1355
Query: 559 LNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKK- 617
L + DE + + +T Q+L GLAYLH+ I+HRD+K NIL+D G +K DFG +KK
Sbjct: 1356 LEHGRIEDEMVTQVYTLQLLEGLAYLHESGIVHRDVKPENILLDFNGVIKYVDFGAAKKI 1415
Query: 618 ------LSPLNK----------------------QQNKRASLQGSVYWMAPEVVKQVVTT 649
L+ +NK +N + G+ +MAPE + T
Sbjct: 1416 ANNGTRLASMNKIENADGEHEDVTHVSDSKAVKNNENALLDMMGTPMYMAPESITGSTTK 1475
Query: 650 EKA---DIWSVGCVIVEMFTGKHPFPDFSQMQAI-FKIGTNIIPEIPS--WVSEEAKAFL 703
K D+WS+GCV++EM TG+ P+ + AI + + P+ P+ VS FL
Sbjct: 1476 GKLGADDVWSLGCVVLEMITGRRPWANLDNEWAIMYHVAAGHTPQFPTKDEVSSAGMKFL 1535
Query: 704 FKSFELDYRKRPSSLGLLQEPWL 726
+ + KR S++ LL +PW+
Sbjct: 1536 ERCLIQNPSKRASAVELLMDPWI 1558
>Hs4505599 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 525
Score = 159 bits (403), Expect = 1e-38
Identities = 93/292 (31%), Positives = 158/292 (53%), Gaps = 39/292 (13%)
Query: 437 KSWLKGARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGG 496
K + + +IG G+ G+V+ + G+ +A+KQ+ L+ + KK
Sbjct: 247 KKYTRYEKIGQGASGTVFTATDVALGQEVAIKQINLQK------------QPKK------ 288
Query: 497 GNTAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVS 556
+ + +E+ ++KEL + NIV + S G L + +EY+ GGS++
Sbjct: 289 ----------------ELIINEILVMKELKNPNIVNFLDSYLVGDELFVVMEYLAGGSLT 332
Query: 557 SMLNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISK 616
++ DE + R+ L L +LH +IHRDIK N+L+ ++G VK+TDFG
Sbjct: 333 DVVTETACMDEAQIAAVCRECLQALEFLHANQVIHRDIKSDNVLLGMEGSVKLTDFGFCA 392
Query: 617 KLSPLNKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQ 676
+++P +Q+KR+++ G+ YWMAPEVV + K DIWS+G + +EM G+ P+ + +
Sbjct: 393 QITP---EQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENP 449
Query: 677 MQAIFKIGTNIIPEI--PSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
++A++ I TN PE+ P +S + FL + E+D KR S+ LLQ P+L
Sbjct: 450 LRALYLIATNGTPELQNPEKLSPIFRDFLNRCLEMDVEKRGSAKELLQHPFL 501
>HsM5454174 [T] KOG0201 Serine/threonine protein kinase
Length = 426
Score = 156 bits (395), Expect = 9e-38
Identities = 99/296 (33%), Positives = 151/296 (50%), Gaps = 37/296 (12%)
Query: 431 TKVEAPKSWLKGARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKK 490
++V+ + + K RIG GSFG VY G++ T E++A+K ++L+ DE
Sbjct: 12 SRVDPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAE---------DE--- 59
Query: 491 AHSPGGGNTAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYV 550
I+ +Q E+ +L + I Y+GS + L I +EY+
Sbjct: 60 ---------------------IEDIQQEITVLSQCDSPYITRYFGSYLKSTKLWIIMEYL 98
Query: 551 PGGSVSSMLNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKIT 610
GGS +L GP +E + R+IL GL YLH IHRDIK AN+L+ +G VK+
Sbjct: 99 GGGSALDLLKP-GPLEETYIATILREILKGLDYLHSERKIHRDIKAANVLLSEQGDVKLA 157
Query: 611 DFGISKKLSPLNKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHP 670
DFG++ +L+ Q KR + G+ +WMAPEV+KQ KADIWS+G +E+ G+ P
Sbjct: 158 DFGVAGQLTDT---QIKRNTFVGTPFWMAPEVIKQSAYDFKADIWSLGITAIELAKGEPP 214
Query: 671 FPDFSQMQAIFKIGTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
D M+ +F I N P + S+ K F+ D R RP++ LL+ ++
Sbjct: 215 NSDLHPMRVLFLIPKNSPPTLEGQHSKPFKEFVEACLNKDPRFRPTAKELLKHKFI 270
>Hs21361358 [T] KOG0201 Serine/threonine protein kinase
Length = 426
Score = 156 bits (395), Expect = 9e-38
Identities = 99/296 (33%), Positives = 151/296 (50%), Gaps = 37/296 (12%)
Query: 431 TKVEAPKSWLKGARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKK 490
++V+ + + K RIG GSFG VY G++ T E++A+K ++L+ DE
Sbjct: 12 SRVDPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAE---------DE--- 59
Query: 491 AHSPGGGNTAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYV 550
I+ +Q E+ +L + I Y+GS + L I +EY+
Sbjct: 60 ---------------------IEDIQQEITVLSQCDSPYITRYFGSYLKSTKLWIIMEYL 98
Query: 551 PGGSVSSMLNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKIT 610
GGS +L GP +E + R+IL GL YLH IHRDIK AN+L+ +G VK+
Sbjct: 99 GGGSALDLLKP-GPLEETYIATILREILKGLDYLHSERKIHRDIKAANVLLSEQGDVKLA 157
Query: 611 DFGISKKLSPLNKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHP 670
DFG++ +L+ Q KR + G+ +WMAPEV+KQ KADIWS+G +E+ G+ P
Sbjct: 158 DFGVAGQLTDT---QIKRNTFVGTPFWMAPEVIKQSAYDFKADIWSLGITAIELAKGEPP 214
Query: 671 FPDFSQMQAIFKIGTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
D M+ +F I N P + S+ K F+ D R RP++ LL+ ++
Sbjct: 215 NSDLHPMRVLFLIPKNSPPTLEGQHSKPFKEFVEACLNKDPRFRPTAKELLKHKFI 270
>CE28674 [T] KOG0201 Serine/threonine protein kinase
Length = 651
Score = 155 bits (391), Expect = 3e-37
Identities = 99/297 (33%), Positives = 150/297 (50%), Gaps = 38/297 (12%)
Query: 431 TKVEAPKSWLKGARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKK 490
+K++ + K RIG GSFG VY G++ TG ++A+K ++L+ DE
Sbjct: 24 SKLDPEVIFTKQERIGRGSFGEVYKGIDNRTGRVVAIKIIDLEQAE---------DE--- 71
Query: 491 AHSPGGGNTAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYV 550
I+ +Q E+ +L + + + Y+GS +G L I +EY+
Sbjct: 72 ---------------------IEDIQQEIQVLSQCDSQYVTKYFGSFLKGSKLWIIMEYL 110
Query: 551 PGGSVSSMLNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKIT 610
GGS + + G DE + R+IL GL YLH IHRDIK AN+L+ G VK+
Sbjct: 111 GGGSALDLTKS-GKLDESHIAVILREILKGLEYLHSERKIHRDIKAANVLVSEHGDVKVA 169
Query: 611 DFGISKKLSPLNKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHP 670
DFG++ +L+ K KR + GS +WMAPE++KQ KADIWS+G +E+ G+ P
Sbjct: 170 DFGVAGQLTETVK---KRITFVGSPFWMAPELIKQSSYDYKADIWSLGITAIELANGEPP 226
Query: 671 FPDFSQMQAIFKIGTNIIPEIP-SWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
D M+ +F I N P + S S+ K F+ D RPS+ LL+ ++
Sbjct: 227 HSDLHPMRVLFLIPKNPPPVLQGSQWSKPFKEFVEMCLNKDPENRPSASTLLKHQFI 283
>CE07510 [T] KOG0201 Serine/threonine protein kinase
Length = 653
Score = 154 bits (390), Expect = 4e-37
Identities = 99/296 (33%), Positives = 149/296 (49%), Gaps = 38/296 (12%)
Query: 432 KVEAPKSWLKGARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKA 491
K++ + K RIG GSFG VY G++ TG ++A+K ++L+ DE
Sbjct: 27 KLDPEVIFTKQERIGRGSFGEVYKGIDNRTGRVVAIKIIDLEQAE---------DE---- 73
Query: 492 HSPGGGNTAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVP 551
I+ +Q E+ +L + + + Y+GS +G L I +EY+
Sbjct: 74 --------------------IEDIQQEIQVLSQCDSQYVTKYFGSFLKGSKLWIIMEYLG 113
Query: 552 GGSVSSMLNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITD 611
GGS + + G DE + R+IL GL YLH IHRDIK AN+L+ G VK+ D
Sbjct: 114 GGSALDLTKS-GKLDESHIAVILREILKGLEYLHSERKIHRDIKAANVLVSEHGDVKVAD 172
Query: 612 FGISKKLSPLNKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPF 671
FG++ +L+ K KR + GS +WMAPE++KQ KADIWS+G +E+ G+ P
Sbjct: 173 FGVAGQLTETVK---KRITFVGSPFWMAPELIKQSSYDYKADIWSLGITAIELANGEPPH 229
Query: 672 PDFSQMQAIFKIGTNIIPEIP-SWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
D M+ +F I N P + S S+ K F+ D RPS+ LL+ ++
Sbjct: 230 SDLHPMRVLFLIPKNPPPVLQGSQWSKPFKEFVEMCLNKDPENRPSASTLLKHQFI 285
>Hs4505601 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 544
Score = 154 bits (389), Expect = 5e-37
Identities = 94/292 (32%), Positives = 158/292 (53%), Gaps = 40/292 (13%)
Query: 437 KSWLKGARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGG 496
K + + +IG G+ G+VY ++ TG+ +A+KQ+ L+ + KK
Sbjct: 266 KKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQ------------QQPKK------ 307
Query: 497 GNTAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVS 556
+ + +E+ +++E + NIV Y S G L + +EY+ GGS++
Sbjct: 308 ----------------ELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLT 351
Query: 557 SMLNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISK 616
++ DE + R+ L L +LH +IHRDIK NIL+ + G VK+TDFG
Sbjct: 352 DVVTETC-MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCA 410
Query: 617 KLSPLNKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQ 676
+++P +Q+KR+++ G+ YWMAPEVV + K DIWS+G + +EM G+ P+ + +
Sbjct: 411 QITP---EQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENP 467
Query: 677 MQAIFKIGTNIIPEI--PSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
++A++ I TN PE+ P +S + FL + E+D +R S+ LLQ P+L
Sbjct: 468 LRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFL 519
>Hs7382496 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 545
Score = 154 bits (388), Expect = 6e-37
Identities = 94/292 (32%), Positives = 157/292 (53%), Gaps = 40/292 (13%)
Query: 437 KSWLKGARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGG 496
K + + +IG G+ G+VY M+ TG+ +A+KQ+ L+ + KK
Sbjct: 268 KKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQ------------QQPKK------ 309
Query: 497 GNTAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVS 556
+ + +E+ +++E + NIV Y S G L + +EY+ GGS++
Sbjct: 310 ----------------ELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLT 353
Query: 557 SMLNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISK 616
++ DE + R+ L L +LH +IHRDIK NIL+ + G VK+TDFG
Sbjct: 354 DVVTETC-MDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCA 412
Query: 617 KLSPLNKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQ 676
+++P +Q+KR+++ G+ YWMAPEVV + K DIWS+G + +EM G+ P+ + +
Sbjct: 413 QITP---EQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENP 469
Query: 677 MQAIFKIGTNIIPEI--PSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
++A++ I TN PE+ P +S + FL + ++D KR S+ LLQ +L
Sbjct: 470 LRALYLIATNGTPELQNPEKLSAIFRDFLNRCLDMDVEKRGSAKELLQHQFL 521
>Hs15011880 [T] KOG0201 Serine/threonine protein kinase
Length = 416
Score = 154 bits (388), Expect = 6e-37
Identities = 94/283 (33%), Positives = 145/283 (51%), Gaps = 37/283 (13%)
Query: 444 RIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKN 503
RIG GSFG V+ G++ T +++A+K ++L+ DE
Sbjct: 29 RIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAE---------DE---------------- 63
Query: 504 TSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNYG 563
I+ +Q E+ +L + + YYGS +G L I +EY+ GGS +L G
Sbjct: 64 --------IEDIQQEITVLSQCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRA-G 114
Query: 564 PFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPLNK 623
PFDE + ++IL GL YLH IHRDIK AN+L+ +G VK+ DFG++ +L+
Sbjct: 115 PFDEFQIATMLKEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLT---D 171
Query: 624 QQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAIFKI 683
Q KR + G+ +WMAPEV++Q KADIWS+G +E+ G+ P D M+ +F I
Sbjct: 172 TQIKRNTFVGTPFWMAPEVIQQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLI 231
Query: 684 GTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
N P + ++ K F+ D RP++ LL+ ++
Sbjct: 232 PKNNPPTLVGDFTKSFKEFIDACLNKDPSFRPTAKELLKHKFI 274
>CE27177 [T] KOG4279 Serine/threonine protein kinase
Length = 1378
Score = 153 bits (387), Expect = 8e-37
Identities = 101/293 (34%), Positives = 160/293 (54%), Gaps = 48/293 (16%)
Query: 445 IGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKNT 504
+G G++G+VY + +T + VK++E+K
Sbjct: 670 LGKGTYGTVYAARDMDTQRQIVVKEIEVK------------------------------- 698
Query: 505 SQIHRKMIDALQHEMNILKELHHENIVTYYGSS---QEGGNLN--IFLEYVPGGSVSSML 559
+ + + L E+++ L H NIV Y G ++G N + IF+E+VPGGS+SS+L
Sbjct: 699 ---YDEEVQPLMEEISLHSTLCHANIVQYLGCDLVGKDGSNDHFLIFMEHVPGGSLSSLL 755
Query: 560 NN-YGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGV-KITDFGISKK 617
+ +GP +E + + +QIL GL YLH+ I+HRDIKG N+L++ GV KI+DFG K+
Sbjct: 756 RSKWGPMNENAMNYYGKQILEGLKYLHELKIVHRDIKGDNVLVNTYSGVCKISDFGTCKR 815
Query: 618 LSPLNKQQNKRASLQGSVYWMAPEVVK--QVVTTEKADIWSVGCVIVEMFTGKHPFPDFS 675
L+ LN + G++ +MAPEV+ Q ADIWS GC +VEM TG+ PF +
Sbjct: 816 LAGLNPVTE---TFTGTLQYMAPEVIDHGQRGYGAPADIWSFGCTMVEMATGRPPFVEMQ 872
Query: 676 QMQ-AIFKIGT-NIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
Q A+F++G P IP+ ++E+ + F+ F + RPS+ LLQ+P++
Sbjct: 873 NPQAAMFRVGMFKTHPPIPTEITEKCRNFIKSCFLPEACDRPSAKDLLQDPFI 925
>7300224 [T] KOG0201 Serine/threonine protein kinase
Length = 642
Score = 153 bits (387), Expect = 8e-37
Identities = 95/300 (31%), Positives = 153/300 (50%), Gaps = 37/300 (12%)
Query: 427 ISLPTKVEAPKSWLKGARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIAD 486
+S KV+ + K RIG GSFG V+ G++ T +++A+K ++L+ D
Sbjct: 1 MSWTEKVDPELIFTKQERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAE---------D 51
Query: 487 ESKKAHSPGGGNTAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIF 546
E ID +Q E+ +L + + YYGS +G L I
Sbjct: 52 E------------------------IDDIQQEIMVLSQCDSPYVTKYYGSFLKGTKLWII 87
Query: 547 LEYVPGGSVSSMLNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGG 606
+EY+ GGS ++ G F+E + R++L GL YLH +HRDIK AN+L+ +G
Sbjct: 88 MEYLGGGSALDLMKA-GSFEEMHIGIILREVLKGLDYLHSERKLHRDIKAANVLLSEQGD 146
Query: 607 VKITDFGISKKLSPLNKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFT 666
VK+ DFG++ +L+ +KR + G+ +WMAPEV+KQ KADIWS+G +E+
Sbjct: 147 VKLADFGVAGQLT---NTTSKRNTFVGTPFWMAPEVIKQSQYDAKADIWSLGITAIELAK 203
Query: 667 GKHPFPDFSQMQAIFKIGTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
G+ P + M+ +F I N P++ ++ K F+ D RP++ LL+ P++
Sbjct: 204 GEPPNSELHPMRVLFLIPKNNPPQLTGSYTKSFKDFVEACLNKDPENRPTAKELLKYPFI 263
>7298926 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 704
Score = 153 bits (387), Expect = 8e-37
Identities = 93/292 (31%), Positives = 157/292 (52%), Gaps = 40/292 (13%)
Query: 437 KSWLKGARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGG 496
+ + K +IG G+ G+VY + + TG +A+KQ+ L + + KK
Sbjct: 428 RKYTKMEKIGQGASGTVYTAIESSTGMEVAIKQMNL------------SQQPKK------ 469
Query: 497 GNTAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVS 556
+ + +E+ +++E H N+V Y S L + +EY+PGGS++
Sbjct: 470 ----------------ELIINEILVMRENKHPNVVNYLDSYLVSEELWVVMEYLPGGSLT 513
Query: 557 SMLNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISK 616
++ DE + R++L L +LH +IHRDIK NIL+ + G VK+TDFG
Sbjct: 514 DVVTETC-MDEGQIAAVCREVLQALEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFCA 572
Query: 617 KLSPLNKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQ 676
++SP +Q+KR ++ G+ YWMAPEVV + K D+WS+G + +EM G+ P+ + +
Sbjct: 573 QISP---EQSKRTTMVGTPYWMAPEVVTRKQYGPKVDLWSLGIMAIEMVEGEPPYLNENP 629
Query: 677 MQAIFKIGTNIIPEI--PSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
++A++ I TN PEI +S + FL + E++ +R S+L LL+ P+L
Sbjct: 630 LKALYLIATNGKPEIKEKDKLSSAFQDFLDQCLEVEVDRRASALDLLKHPFL 681
>At5g55090 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 448
Score = 152 bits (383), Expect = 2e-36
Identities = 101/300 (33%), Positives = 155/300 (51%), Gaps = 55/300 (18%)
Query: 437 KSWLKGARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGG 496
++W++G IG GS +V LG+ +G+ AVK E +A
Sbjct: 4 QNWIRGPIIGRGSTATVSLGIT-NSGDFFAVKSAEFSSSAF------------------- 43
Query: 497 GNTAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGN----LNIFLEYVPG 552
LQ E +IL +L IV Y GS+ N N+ +EYV G
Sbjct: 44 ------------------LQREQSILSKLSSPYIVKYIGSNVTKENDKLMYNLLMEYVSG 85
Query: 553 GSVSSMLNNYG-PFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGG--VKI 609
GS+ ++ N G EPL++++TRQIL GL YLH + I+H D+K N++I GG KI
Sbjct: 86 GSLHDLIKNSGGKLPEPLIRSYTRQILKGLMYLHDQGIVHCDVKSQNVMI---GGEIAKI 142
Query: 610 TDFGISKKLSPLNKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKH 669
D G +K + ++N+ G+ +M+PEV + + AD+W++GC ++EM TG
Sbjct: 143 VDLGCAKTV-----EENENLEFSGTPAFMSPEVARGEEQSFPADVWALGCTVIEMATGSS 197
Query: 670 PFPDFSQ-MQAIFKIG-TNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWLN 727
P+P+ + + AI+KIG T P IP W+SE+ + FL K D ++R + LLQ P+L+
Sbjct: 198 PWPELNDVVAAIYKIGFTGESPVIPVWLSEKGQDFLRKCLRKDPKQRWTVEELLQHPFLD 257
>CE27670 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 572
Score = 151 bits (381), Expect = 4e-36
Identities = 96/295 (32%), Positives = 154/295 (51%), Gaps = 46/295 (15%)
Query: 437 KSWLKGARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGG 496
+ + K +IGSG+ GSVY + T +A+KQ+ LK D+ KK
Sbjct: 293 RKYRKVDKIGSGASGSVYTAIEISTEAEVAIKQMNLK------------DQPKK------ 334
Query: 497 GNTAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVS 556
+ + +E+ +++E H NIV Y S L + +EY+ GGS++
Sbjct: 335 ----------------ELIINEILVMRENKHANIVNYLDSYLVCDELWVVMEYLAGGSLT 378
Query: 557 SMLNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISK 616
++ ++ ++ R++L L +LH R++IHRDIK NIL+ + G VK+TDFG
Sbjct: 379 DVVTEC-QMEDGIIAAVCREVLQALEFLHSRHVIHRDIKSDNILLGMDGSVKLTDFGFCA 437
Query: 617 KLSPLNKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQ 676
+LSP +Q KR ++ G+ YWMAPEVV + K D+WS+G + +EM G+ P+ + +
Sbjct: 438 QLSP---EQRKRTTMVGTPYWMAPEVVTRKQYGPKVDVWSLGIMAIEMVEGEPPYLNENP 494
Query: 677 MQAIFKIGTNIIPEIPSWVSEEAKAFLFKSF-----ELDYRKRPSSLGLLQEPWL 726
++AI+ I TN P+ P ++ LFK F E+ R S+ LL P+L
Sbjct: 495 LRAIYLIATNGKPDFP---GRDSMTLLFKDFVDSALEVQVENRWSASQLLTHPFL 546
>At4g26890 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 444
Score = 150 bits (380), Expect = 5e-36
Identities = 95/297 (31%), Positives = 159/297 (52%), Gaps = 53/297 (17%)
Query: 438 SWLKGARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGG 497
+W +G IG GS +V + +++ +GEL AVK +L +++
Sbjct: 4 NWTRGPIIGRGSTATVSIAISS-SGELFAVKSADLSSSSL-------------------- 42
Query: 498 NTAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGS--SQEGGNL--NIFLEYVPGG 553
LQ E +IL L ++V Y G+ ++E L NI +EYV GG
Sbjct: 43 -----------------LQKEQSILSTLSSPHMVKYIGTGLTRESNGLVYNILMEYVSGG 85
Query: 554 SVSSMLNNYG-PFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDF 612
++ ++ N G EP ++++TRQIL GL YLH+R I+H D+K N+L++ G +KI D
Sbjct: 86 NLHDLIKNSGGKLPEPEIRSYTRQILNGLVYLHERGIVHCDLKSHNVLVEENGVLKIADM 145
Query: 613 GISKKLSPLNKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFP 672
G +K + ++ G+ +MAPEV + AD+W++GC ++EM TG P+P
Sbjct: 146 GCAKSVD--------KSEFSGTPAFMAPEVARGEEQRFPADVWALGCTMIEMMTGSSPWP 197
Query: 673 DFSQ-MQAIFKIG-TNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWLN 727
+ + + A++KIG + P IP+W+S++AK FL + D ++R + LL+ P+L+
Sbjct: 198 ELNDVVAAMYKIGFSGESPAIPAWISDKAKDFLKNCLKEDQKQRWTVEELLKHPFLD 254
>Hs20070158 [T] KOG0201 Serine/threonine protein kinase
Length = 443
Score = 149 bits (376), Expect = 1e-35
Identities = 94/295 (31%), Positives = 147/295 (48%), Gaps = 37/295 (12%)
Query: 432 KVEAPKSWLKGARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKA 491
K + + + K +IG GSFG V+ G++ T +++A+K ++L+ DE
Sbjct: 29 KADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAE---------DE---- 75
Query: 492 HSPGGGNTAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVP 551
I+ +Q E+ +L + + YYGS + L I +EY+
Sbjct: 76 --------------------IEDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLG 115
Query: 552 GGSVSSMLNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITD 611
GGS +L GP DE + R+IL GL YLH IHRDIK AN+L+ G VK+ D
Sbjct: 116 GGSALDLLEP-GPLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLAD 174
Query: 612 FGISKKLSPLNKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPF 671
FG++ +L+ Q KR + G+ +WMAPEV+KQ KADIWS+G +E+ G+ P
Sbjct: 175 FGVAGQLTDT---QIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPH 231
Query: 672 PDFSQMQAIFKIGTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
+ M+ +F I N P + S+ K F+ + RP++ LL+ ++
Sbjct: 232 SELHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFI 286
>Hs6031180 [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and related
serine/threonine protein kinases
Length = 1558
Score = 148 bits (373), Expect = 3e-35
Identities = 92/293 (31%), Positives = 146/293 (49%), Gaps = 39/293 (13%)
Query: 439 WLKGARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGN 498
W +G +IG G +G VY ++ +TGELMA+K++ +P
Sbjct: 1293 WQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPN----------------------- 1329
Query: 499 TAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSM 558
K I E+ I + + H N+V Y+G + IF+EY G++
Sbjct: 1330 ---------DHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEE- 1379
Query: 559 LNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKL 618
++ G E +++ +++QI I + LH+ I+HRDIKGANI + G +K+ DFG S KL
Sbjct: 1380 VSRLG-LQEHVIRLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKL 1438
Query: 619 -SPLNKQQNKRASLQGSVYWMAPEVVKQVVTT---EKADIWSVGCVIVEMFTGKHPFPDF 674
+ + S G+ +MAPEV+ + ADIWS+GCV++EM TGK P+ ++
Sbjct: 1439 KNNAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEY 1498
Query: 675 S-QMQAIFKIGTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
Q ++K+G P IP +S E K FL E D + R ++ LL ++
Sbjct: 1499 EHNFQIMYKVGMGHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFV 1551
>Hs5803088 [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and related
serine/threonine protein kinases
Length = 1607
Score = 148 bits (373), Expect = 3e-35
Identities = 92/293 (31%), Positives = 146/293 (49%), Gaps = 39/293 (13%)
Query: 439 WLKGARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGN 498
W +G +IG G +G VY ++ +TGELMA+K++ +P
Sbjct: 1342 WQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPN----------------------- 1378
Query: 499 TAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSM 558
K I E+ I + + H N+V Y+G + IF+EY G++
Sbjct: 1379 ---------DHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEE- 1428
Query: 559 LNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKL 618
++ G E +++ +++QI I + LH+ I+HRDIKGANI + G +K+ DFG S KL
Sbjct: 1429 VSRLG-LQEHVIRLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKL 1487
Query: 619 -SPLNKQQNKRASLQGSVYWMAPEVVKQVVTT---EKADIWSVGCVIVEMFTGKHPFPDF 674
+ + S G+ +MAPEV+ + ADIWS+GCV++EM TGK P+ ++
Sbjct: 1488 KNNAQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEY 1547
Query: 675 S-QMQAIFKIGTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
Q ++K+G P IP +S E K FL E D + R ++ LL ++
Sbjct: 1548 EHNFQIMYKVGMGHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFV 1600
>At3g15220 [T] KOG0201 Serine/threonine protein kinase
Length = 690
Score = 147 bits (371), Expect = 6e-35
Identities = 90/283 (31%), Positives = 143/283 (49%), Gaps = 37/283 (13%)
Query: 445 IGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKNT 504
IG GSFG VY + + + +A+K ++L+ + DE
Sbjct: 21 IGRGSFGDVYKAFDKDLNKEVAIKVIDLEESE---------DE----------------- 54
Query: 505 SQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNYGP 564
I+ +Q E+++L + I YYGS L I +EY+ GGSV+ +L + P
Sbjct: 55 -------IEDIQKEISVLSQCRCPYITEYYGSYLHQTKLWIIMEYMAGGSVADLLQSNNP 107
Query: 565 FDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPLNKQ 624
DE + TR +L + YLH IHRDIK ANIL+ G VK+ DFG+S +L+ +
Sbjct: 108 LDETSIACITRDLLHAVEYLHNEGKIHRDIKAANILLSENGDVKVADFGVSAQLT---RT 164
Query: 625 QNKRASLQGSVYWMAPEVVKQVV-TTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAIFKI 683
++R + G+ +WMAPEV++ EKADIWS+G ++EM G+ P D M+ +F I
Sbjct: 165 ISRRKTFVGTPFWMAPEVIQNSEGYNEKADIWSLGITVIEMAKGEPPLADLHPMRVLFII 224
Query: 684 GTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
P++ S + K F+ + +RPS+ L++ ++
Sbjct: 225 PRETPPQLDEHFSRQVKEFVSLCLKKAPAERPSAKELIKHRFI 267
>YNL298w [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 842
Score = 146 bits (368), Expect = 1e-34
Identities = 94/294 (31%), Positives = 157/294 (52%), Gaps = 28/294 (9%)
Query: 444 RIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKN 503
+ G G+ GSVYL PT + I ++ + H G A+K
Sbjct: 551 KAGQGASGSVYLAERTHI------------PTESNM-IELINNDIDEPHV--GDKVAIKQ 595
Query: 504 TSQIHRKMIDALQHEMNILKELHHENIVTYYGSS-QEGGNLNIFLEYVPGGSVSSML--- 559
+ + + +E+ ++K+ H+NIV + + + +L + +E++ GGS++ ++
Sbjct: 596 MVLSKQPRKELIVNEILVMKDSRHKNIVNFLEAYLRTDDDLWVVMEFMEGGSLTDIIENS 655
Query: 560 ----NNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGIS 615
N++ P EP + R+ GL +LH ++IIHRDIK N+L+D + VKITDFG
Sbjct: 656 PTNDNSHSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRARVKITDFGFC 715
Query: 616 KKLSPLNKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFS 675
+L+ +++KRA++ G+ YWMAPEVVKQ EK D+WS+G + +EM G+ P+ +
Sbjct: 716 ARLTD---KRSKRATMVGTPYWMAPEVVKQREYDEKIDVWSLGIMTIEMLEGEPPYLNED 772
Query: 676 QMQAIFKIGTNIIPEI--PSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWLN 727
++A++ I TN P++ P +S E K FL +D R R S+ LL + N
Sbjct: 773 PLKALYLIATNGTPKLKHPESLSLEIKRFLSVCLCVDVRYRASTEELLHHGFFN 826
>SPAC9G1.09 [T] KOG0201 Serine/threonine protein kinase
Length = 471
Score = 146 bits (368), Expect = 1e-34
Identities = 92/286 (32%), Positives = 149/286 (51%), Gaps = 38/286 (13%)
Query: 444 RIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKN 503
++GSGSFG V+ +G+++A+KQ++L+ G+ I D
Sbjct: 14 KLGSGSFGVVWKARENVSGDIIAIKQIDLE-----TGIDDITD----------------- 51
Query: 504 TSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNYG 563
++ E+ +L + N++ YYG +G L I +E++ GGSVS +L G
Sbjct: 52 -----------IEQEVFMLSNCNSSNVIQYYGCFVDGYTLWILMEHMDGGSVSGLLK-MG 99
Query: 564 PFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIK-GGVKITDFGISKKLSPLN 622
+E ++ R++L GL YLH +N IHRDIK ANIL+ G VK+ DFG++ +LS
Sbjct: 100 RLNEQVISIILREVLYGLNYLHGQNKIHRDIKAANILLSSSTGNVKLADFGVAAQLS--- 156
Query: 623 KQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAIFK 682
++R + G+ +WMAPEV++Q ADIWS+G +EM G P M+ IF+
Sbjct: 157 NAASRRHTFVGTPFWMAPEVIQQTSYGLAADIWSLGITAIEMANGIPPRATMHPMRVIFE 216
Query: 683 IGTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWLNT 728
I + P++ S + F+ +L+ R S+ LLQ P++ +
Sbjct: 217 IPQSEPPKLDDHFSPTFRDFVSCCLDLNPNMRWSAKELLQHPFIKS 262
>At1g53165 [T] KOG0201 Serine/threonine protein kinase
Length = 1007
Score = 142 bits (358), Expect = 2e-33
Identities = 91/283 (32%), Positives = 141/283 (49%), Gaps = 37/283 (13%)
Query: 445 IGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKNT 504
IG GSFG VY + E + +A+K ++L+ + DE
Sbjct: 348 IGRGSFGDVYKAFDTELNKDVAIKVIDLEESE---------DE----------------- 381
Query: 505 SQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNYGP 564
I+ +Q E+++L + I YYGS L I +EY+ GGSV+ +L P
Sbjct: 382 -------IEDIQKEISVLSQCRCPYITEYYGSYLHQTKLWIIMEYMAGGSVADLLQPGNP 434
Query: 565 FDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPLNKQ 624
DE + TR +L + YLH IHRDIK ANIL+ G VK+ DFG+S +L+ +
Sbjct: 435 LDEISIACITRDLLHAVEYLHAEGKIHRDIKAANILLSENGDVKVADFGVSAQLT---RT 491
Query: 625 QNKRASLQGSVYWMAPEVVKQVV-TTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAIFKI 683
++R + G+ +WMAPEV++ EKADIWS+G ++EM G+ P D M+ +F I
Sbjct: 492 ISRRKTFVGTPFWMAPEVIQNSEGYNEKADIWSLGITMIEMAKGEPPLADLHPMRVLFII 551
Query: 684 GTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
P++ S K F+ + +RP++ LL+ ++
Sbjct: 552 PRESPPQLDEHFSRPLKEFVSFCLKKAPAERPNAKELLKHRFI 594
>Hs8393810_1 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 336
Score = 140 bits (354), Expect = 5e-33
Identities = 91/258 (35%), Positives = 136/258 (52%), Gaps = 21/258 (8%)
Query: 489 KKAHSPGGGNTAVKNTSQIHRKMIDALQHEMNILKELH-HENIVTYYG-----SSQEGGN 542
K + G AVK IH + + ++ E NILK L H N+V +YG G
Sbjct: 37 KVLNKKNGQKAAVKILDPIH-DIDEEIEAEYNILKALSDHPNVVRFYGIYFKKDKVNGDK 95
Query: 543 LNIFLEYVPGGSVSSMLNNY----GPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGAN 598
L + LE GGSV+ ++ + EPL+ + L+GL +LH IHRD+KG N
Sbjct: 96 LWLVLELCSGGSVTDLVKGFLKRGERMSEPLIAYILHEALMGLQHLHNNKTIHRDVKGNN 155
Query: 599 ILIDIKGGVKITDFGISKKLSPLNKQQNKRASLQGSVYWMAPEVV---KQVVTT--EKAD 653
IL+ +GGVK+ DFG+S +L+ +++R + G+ +WMAPEV+ +Q+ TT + D
Sbjct: 156 ILLTTEGGVKLVDFGVSAQLT---STRHRRNTSVGTPFWMAPEVIACEQQLDTTYDARCD 212
Query: 654 IWSVGCVIVEMFTGKHPFPDFSQMQAIFKIGTNIIPEI--PSWVSEEAKAFLFKSFELDY 711
WS+G +E+ G P D M+A+FKI N P++ P S E F+ K DY
Sbjct: 213 TWSLGITAIELGDGDPPLADLHPMRALFKIPRNPPPKLRQPELWSAEFNDFISKCLTKDY 272
Query: 712 RKRPSSLGLLQEPWLNTV 729
KRP+ LLQ ++ +
Sbjct: 273 EKRPTVSELLQHKFITQI 290
>Hs20544910_1 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 336
Score = 140 bits (354), Expect = 5e-33
Identities = 91/258 (35%), Positives = 136/258 (52%), Gaps = 21/258 (8%)
Query: 489 KKAHSPGGGNTAVKNTSQIHRKMIDALQHEMNILKELH-HENIVTYYG-----SSQEGGN 542
K + G AVK IH + + ++ E NILK L H N+V +YG G
Sbjct: 37 KVLNKKNGQKAAVKILDPIH-DIDEEIEAEYNILKALSDHPNVVRFYGIYFKKDKVNGDK 95
Query: 543 LNIFLEYVPGGSVSSMLNNY----GPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGAN 598
L + LE GGSV+ ++ + EPL+ + L+GL +LH IHRD+KG N
Sbjct: 96 LWLVLELCSGGSVTDLVKGFLKRGERMSEPLIAYILHEALMGLQHLHNNKTIHRDVKGNN 155
Query: 599 ILIDIKGGVKITDFGISKKLSPLNKQQNKRASLQGSVYWMAPEVV---KQVVTT--EKAD 653
IL+ +GGVK+ DFG+S +L+ +++R + G+ +WMAPEV+ +Q+ TT + D
Sbjct: 156 ILLTTEGGVKLVDFGVSAQLT---STRHRRNTSVGTPFWMAPEVIACEQQLDTTYDARCD 212
Query: 654 IWSVGCVIVEMFTGKHPFPDFSQMQAIFKIGTNIIPEI--PSWVSEEAKAFLFKSFELDY 711
WS+G +E+ G P D M+A+FKI N P++ P S E F+ K DY
Sbjct: 213 TWSLGITAIELGDGDPPLADLHPMRALFKIPRNPPPKLRQPELWSAEFNDFISKCLTKDY 272
Query: 712 RKRPSSLGLLQEPWLNTV 729
KRP+ LLQ ++ +
Sbjct: 273 EKRPTVSELLQHKFITQI 290
>At2g32510 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 372
Score = 140 bits (353), Expect = 7e-33
Identities = 90/301 (29%), Positives = 152/301 (49%), Gaps = 53/301 (17%)
Query: 439 WLKGARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGN 498
W +G +G GS +VY + E++AVK
Sbjct: 3 WTRGRILGRGSTATVYAAAGHNSDEILAVK------------------------------ 32
Query: 499 TAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGN-----LNIFLEYVPGG 553
+S++HR + LQ E IL L ++ Y GS + + N+ +EY P G
Sbjct: 33 -----SSEVHRS--EFLQREAKILSSLSSPYVIGYRGSETKRESNGVVMYNLLMEYAPYG 85
Query: 554 SVS-SMLNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDF 612
+++ + + G DE V +TR IL GL Y+H + I+H D+KG+N++I KG KI DF
Sbjct: 86 TLTDAAAKDGGRVDETRVVKYTRDILKGLEYIHSKGIVHCDVKGSNVVISEKGEAKIADF 145
Query: 613 GISKKLSPLNKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFP 672
G +K++ P+ + + + G+ +MAPEV + +++DIW+VGC ++EM TG P+
Sbjct: 146 GCAKRVDPVFE-----SPVMGTPAFMAPEVARGEKQGKESDIWAVGCTMIEMVTGSPPWT 200
Query: 673 DFSQ----MQAIFKIG-TNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWLN 727
+ ++++G ++ PE+P ++EEAK FL K + + +R ++ LL P+L
Sbjct: 201 KADSREDPVSVLYRVGYSSETPELPCLLAEEAKDFLEKCLKREANERWTATQLLNHPFLT 260
Query: 728 T 728
T
Sbjct: 261 T 261
>YAR019c [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 974
Score = 139 bits (350), Expect = 2e-32
Identities = 90/285 (31%), Positives = 141/285 (48%), Gaps = 42/285 (14%)
Query: 445 IGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKNT 504
IG GS+G VY +N T +++A+K+V +N
Sbjct: 31 IGRGSYGVVYKAINKHTDQVVAIKEV-----------------------------VYEND 61
Query: 505 SQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNYGP 564
+++ M E+++LK L+H NIV Y+G ++ L I LEY GS+ +++
Sbjct: 62 EELNDIMA-----EISLLKNLNHNNIVKYHGFIRKSYELYILLEYCANGSLRRLISRSST 116
Query: 565 -FDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPLNK 623
E K + Q L+GL YLH +IHRDIK ANIL+ VK+ DFG+S ++
Sbjct: 117 GLSENESKTYVTQTLLGLKYLHGEGVIHRDIKAANILLSADNTVKLADFGVSTIVN---- 172
Query: 624 QQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAIFKI 683
+ +L G++ WMAPE++ + +DIWS+G +VEM T P+ + + + +
Sbjct: 173 --SSALTLAGTLNWMAPEILGNRGASTLSDIWSLGATVVEMLTKNPPYHNLTDANIYYAV 230
Query: 684 GTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWLNT 728
N PS SE K FL K F + KRP++ LL+ W+N+
Sbjct: 231 -ENDTYYPPSSFSEPLKDFLSKCFVKNMYKRPTADQLLKHVWINS 274
>Hs13376582 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 168
Score = 139 bits (350), Expect = 2e-32
Identities = 68/162 (41%), Positives = 105/162 (63%), Gaps = 5/162 (3%)
Query: 547 LEYVPGGSVSSMLNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGG 606
+E+VPGGS+SS++N +GP E + +T+QIL G+AYLH+ ++HRDIKG N+++ G
Sbjct: 1 MEFVPGGSISSIINRFGPLPEMVFCKYTKQILQGVAYLHENCVVHRDIKGNNVMLMPTGI 60
Query: 607 VKITDFGISKKL--SPLN-KQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVE 663
+K+ DFG +++L + LN + S+ G+ YWM PEV+ + K+DIWS+GC + E
Sbjct: 61 IKLIDFGCARRLAWAGLNGTHSDMLKSMHGTPYWMVPEVINESGYGRKSDIWSIGCTVFE 120
Query: 664 MFTGKHPFPDFSQMQAIFKIGTN--IIPEIPSWVSEEAKAFL 703
M TGK P +M A+F IG + ++P +P SE A F+
Sbjct: 121 MATGKPPLASMDRMAAMFYIGAHRGLMPPLPDHFSENAADFV 162
>SPAC2C4.14c [T] KOG0201 Serine/threonine protein kinase
Length = 312
Score = 139 bits (349), Expect = 2e-32
Identities = 86/247 (34%), Positives = 123/247 (48%), Gaps = 36/247 (14%)
Query: 445 IGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKNT 504
IG GSFGSV+ + E+ +++A+K V+L T
Sbjct: 12 IGQGSFGSVFRAQDVESSKIVALKVVDLDAT----------------------------- 42
Query: 505 SQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNYGP 564
+ I+ L E+N L +L+ +I YY S +G L I +EY GGS +L G
Sbjct: 43 ----KDQIETLTQEINFLIDLNSVHITKYYASFVDGFRLWITMEYCDGGSCLDLLKLSGT 98
Query: 565 FDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPLNKQ 624
F E ++ RQ+L L YLH + +HRDIK ANIL G VK+ DFG+S +L L
Sbjct: 99 FSERVIAEVMRQVLEALVYLHGQGKMHRDIKAANILTMKDGLVKLADFGVSGQLESL--- 155
Query: 625 QNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAIFKIG 684
++K G+ +WMAPEVVKQ KADIWS+G E+ TG+ P+ M+ + I
Sbjct: 156 RDKNDDFVGTPFWMAPEVVKQTGYNYKADIWSLGITAYELATGEPPYSGIHPMKVLLLIP 215
Query: 685 TNIIPEI 691
+ P +
Sbjct: 216 KHSPPSL 222
>Hs15451902 [T] KOG0576 Mitogen-activated protein kinase kinase kinase kinase
(MAP4K) germinal center kinase family
Length = 894
Score = 139 bits (349), Expect = 2e-32
Identities = 96/291 (32%), Positives = 147/291 (49%), Gaps = 46/291 (15%)
Query: 444 RIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKN 503
RIGSG++G VY N TGEL A+K ++L+P G + AV
Sbjct: 21 RIGSGTYGDVYKARNVNTGELAAIKVIKLEP---------------------GEDFAV-- 57
Query: 504 TSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNYG 563
+Q E+ ++K+ H NIV Y+GS L I +E+ GGS+ + + G
Sbjct: 58 -----------VQQEIIMMKDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTG 106
Query: 564 PFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPLNK 623
P E + +R+ L GL YLH + +HRDIKGANIL+ G VK+ DFG+S +++
Sbjct: 107 PLSELQIAYVSRETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIA 166
Query: 624 QQNKRASLQGSVYWMAPEVV---KQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAI 680
KR S G+ YWMAPEV ++ + D+W+VG +E+ + P D M+A+
Sbjct: 167 ---KRKSFIGTPYWMAPEVAAVERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRAL 223
Query: 681 FKI-GTNIIP----EIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
F + +N P + W S F+ + + +KRP++ LLQ P++
Sbjct: 224 FLMTKSNFQPPKLKDKMKW-SNSFHHFVKMALTKNPKKRPTAEKLLQHPFV 273
>Hs5174701 [T] KOG0579 Ste20-like serine/threonine protein kinase
Length = 968
Score = 138 bits (347), Expect = 3e-32
Identities = 95/299 (31%), Positives = 145/299 (47%), Gaps = 45/299 (15%)
Query: 439 WLKGARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGN 498
W +G G+FG VY N ETG L A K +E
Sbjct: 36 WEIVGELGDGAFGKVYKAKNKETGALAAAKVIE--------------------------- 68
Query: 499 TAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSS- 557
K+ ++ ++ E+ IL H IV G+ G L I +E+ PGG+V +
Sbjct: 69 --TKSEEELEDYIV-----EIEILATCDHPYIVKLLGAYYHDGKLWIMIEFCPGGAVDAI 121
Query: 558 MLNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKK 617
ML EP ++ RQ+L L +LH + IIHRD+K N+L+ ++G +++ DFG+S K
Sbjct: 122 MLELDRGLTEPQIQVVCRQMLEALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAK 181
Query: 618 LSPLNKQQNKRASLQGSVYWMAPEVV-----KQVVTTEKADIWSVGCVIVEMFTGKHPFP 672
K KR S G+ YWMAPEVV K KADIWS+G ++EM + P
Sbjct: 182 NL---KTLQKRDSFIGTPYWMAPEVVMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHH 238
Query: 673 DFSQMQAIFKIGTNIIPEI--PSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWLNTV 729
+ + M+ + KI + P + PS S E + FL + + + RPS+ LL+ P+++++
Sbjct: 239 ELNPMRVLLKIAKSDPPTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLEHPFVSSI 297
>SPBC1604.14c [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 658
Score = 137 bits (344), Expect = 8e-32
Identities = 76/231 (32%), Positives = 134/231 (57%), Gaps = 6/231 (2%)
Query: 498 NTAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSS 557
+ A+K + + + + +E+ ++K HH+NIV + + L + +EY+ GGS++
Sbjct: 411 SVAIKKMNINQQPKKEFIVNEILVMKSHHHKNIVNFIDTFFYKSELWMVMEYMRGGSLTE 470
Query: 558 MLNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKK 617
++ N E + ++ L GL +LH+ I+HRDIK NIL+ ++G +K+TDFG +
Sbjct: 471 VVTN-NTLSEGQIAAICKETLEGLQHLHENGIVHRDIKSDNILLSLQGDIKLTDFGFCAQ 529
Query: 618 LSPLNKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQM 677
+ + KR ++ G+ YWMAPEVV + K D+WS+G + +EM G+ P+ + + +
Sbjct: 530 I---DSNMTKRTTMVGTPYWMAPEVVTRKEYGFKVDVWSLGIMAIEMVEGEPPYLNENPL 586
Query: 678 QAIFKIGTNIIPEI--PSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
+A++ I T P+I P +S FL KS ++ ++RPSS LL+ P+L
Sbjct: 587 RALYLIATIGTPKISRPELLSSVFHDFLSKSLTVNPKQRPSSGELLRHPFL 637
>Hs5454096 [T] KOG0574 STE20-like serine/threonine kinase MST
Length = 487
Score = 137 bits (344), Expect = 8e-32
Identities = 88/288 (30%), Positives = 144/288 (49%), Gaps = 42/288 (14%)
Query: 444 RIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKN 503
++G GS+GSVY ++ ETG+++A+KQV ++
Sbjct: 35 KLGEGSYGSVYKAIHKETGQIVAIKQVPVESD---------------------------- 66
Query: 504 TSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLN-NY 562
+ + E++I+++ ++V YYGS + +L I +EY GSVS ++
Sbjct: 67 --------LQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRN 118
Query: 563 GPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPLN 622
E + + L GL YLH IHRDIK NIL++ +G K+ DFG++ +L+
Sbjct: 119 KTLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDT- 177
Query: 623 KQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAIFK 682
KR ++ G+ +WMAPEV++++ ADIWS+G +EM GK P+ D M+AIF
Sbjct: 178 --MAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFM 235
Query: 683 IGTNIIPEI--PSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWLNT 728
I TN P P S+ F+ + +R ++ LLQ P++ +
Sbjct: 236 IPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRS 283
>Hs14589909 [T] KOG0576 Mitogen-activated protein kinase kinase kinase kinase
(MAP4K) germinal center kinase family
Length = 846
Score = 135 bits (341), Expect = 2e-31
Identities = 87/241 (36%), Positives = 121/241 (50%), Gaps = 40/241 (16%)
Query: 444 RIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKN 503
R+GSG++G VY N TGEL AVK ++L+P D+
Sbjct: 25 RVGSGTYGDVYKARNVHTGELAAVKIIKLEP----------GDD---------------- 58
Query: 504 TSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNYG 563
+Q E+ ++KE H NIV Y+GS L I +EY GGS+ + + G
Sbjct: 59 --------FSLIQQEIFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTG 110
Query: 564 PFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPLNK 623
P E + R+ L GLAYLH + +HRDIKGANIL+ G VK+ DFG++ K++
Sbjct: 111 PLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIA 170
Query: 624 QQNKRASLQGSVYWMAPEVV---KQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAI 680
KR S G+ YWMAPEV K + DIW+VG +E+ + P D M+A+
Sbjct: 171 ---KRKSFIGTPYWMAPEVAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRAL 227
Query: 681 F 681
F
Sbjct: 228 F 228
>YHL007c [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 939
Score = 135 bits (340), Expect = 2e-31
Identities = 86/288 (29%), Positives = 148/288 (50%), Gaps = 40/288 (13%)
Query: 444 RIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKN 503
+IG G+ G VY T +A+KQ+ L+ + KK
Sbjct: 625 KIGQGASGGVYTAYEIGTNVSVAIKQMNLEK------------QPKK------------- 659
Query: 504 TSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNYG 563
+ + +E+ ++K H NIV + S G+L + +EY+ GGS++ ++ +
Sbjct: 660 ---------ELIINEILVMKGSKHPNIVNFIDSYVLKGDLWVIMEYMEGGSLTDVVTHC- 709
Query: 564 PFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPLNK 623
E + R+ L GL +LH + ++HRDIK NIL+ ++G +K+TDFG +++ LN
Sbjct: 710 ILTEGQIGAVCRETLSGLEFLHSKGVLHRDIKSDNILLSMEGDIKLTDFGFCAQINELNL 769
Query: 624 QQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAIFKI 683
KR ++ G+ YWMAPEVV + K DIWS+G +I+EM G+ P+ + + ++A++ I
Sbjct: 770 ---KRTTMVGTPYWMAPEVVSRKEYGPKVDIWSLGIMIIEMIEGEPPYLNETPLRALYLI 826
Query: 684 GTNIIPEI--PSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWLNTV 729
TN P++ P +S K FL ++ R S+ LL + ++ +
Sbjct: 827 ATNGTPKLKEPENLSSSLKKFLDWCLCVEPEDRASATELLHDEYITEI 874
>SPCC320.12c [D] KOG0580 Serine/threonine protein kinase
Length = 384
Score = 135 bits (340), Expect = 2e-31
Identities = 81/285 (28%), Positives = 138/285 (48%), Gaps = 36/285 (12%)
Query: 442 GARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAV 501
G +G G FG VYL +TG ++A+K +
Sbjct: 121 GKPLGKGKFGRVYLAKEKKTGFIVALKTLH------------------------------ 150
Query: 502 KNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNN 561
+ + K+ ++ E+ I L H+NI+ YG + + + LE+ G + L
Sbjct: 151 -KSELVQSKIEKQVRREIEIQSNLRHKNILRLYGHFHDEKRIYLILEFAGRGELYQHLRR 209
Query: 562 YGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPL 621
F E + + Q+ L+YLHK+++IHRDIK NIL+ I G +K++DFG S +
Sbjct: 210 AKRFSEEVASKYIFQMANALSYLHKKHVIHRDIKPENILLGIDGEIKLSDFGWS-----V 264
Query: 622 NKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAIF 681
+ N+R +L G++ ++ PE+V+ TEK D+WS+G + E G PF D S A +
Sbjct: 265 HAPSNRRTTLCGTLDYLPPEMVEGKEHTEKVDLWSLGVLTYEFLVGAPPFEDMSGHSATY 324
Query: 682 KIGTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
K + +IPS+V +A+ + + + + KR S +++ PW+
Sbjct: 325 KRIAKVDLKIPSFVPPDARDLISRLLQHNPEKRMSLEQVMRHPWI 369
>SPAC1F5.09c [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 589
Score = 135 bits (339), Expect = 3e-31
Identities = 81/233 (34%), Positives = 129/233 (54%), Gaps = 7/233 (3%)
Query: 498 NTAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQ-EGGNLNIFLEYVPGGSVS 556
+ A+K+ + + + +E+ +++E H NIVTY S +L + +EY+ GS++
Sbjct: 339 SVAIKSIDLQCQTRKELILNEITVMRESIHPNIVTYLDSFLVRERHLWVVMEYMNAGSLT 398
Query: 557 SMLNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISK 616
++ E + + G+ +LH RNIIHRDIK N+L+D G +KITDFG
Sbjct: 399 DIIEK-SKLTEAQIARICLETCKGIQHLHARNIIHRDIKSDNVLLDNSGNIKITDFGFCA 457
Query: 617 KLSPLNKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQ 676
+LS + NKR ++ G+ YWMAPEVVKQ K DIWS+G +I+EM + P+
Sbjct: 458 RLS---NRTNKRVTMVGTPYWMAPEVVKQNEYGTKVDIWSLGIMIIEMIENEPPYLREDP 514
Query: 677 MQAIFKIGTNIIPEI--PSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWLN 727
++A++ I N P + P+ VS+ K+FL +D R ++ LL +LN
Sbjct: 515 IRALYLIAKNGTPTLKKPNLVSKNLKSFLNSCLTIDTIFRATAAELLTHSFLN 567
>At1g07150 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 499
Score = 135 bits (339), Expect = 3e-31
Identities = 94/304 (30%), Positives = 157/304 (50%), Gaps = 48/304 (15%)
Query: 433 VEAPKS-WLKGARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKA 491
+ +P S W++GA IG G FG+V ++ GE+ AVK V+L + T
Sbjct: 16 LSSPSSFWVRGACIGRGCFGAVSTAISKTNGEVFAVKSVDLATSLPTQS----------- 64
Query: 492 HSPGGGNTAVKNTSQIHRKMIDALQHEMNILKELH-HENIVTYYGS--SQEGGNL--NIF 546
++L++E+++ + L H IV + G S+EG N++
Sbjct: 65 ---------------------ESLENEISVFRSLKPHPYIVKFLGDGVSKEGTTTFRNLY 103
Query: 547 LEYVPGGSVSSMLNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGG 606
LEY+P G V+S DE L++ +T ++ L ++H + +H D+K NIL+
Sbjct: 104 LEYLPNGDVASHRAGGKIEDETLLQRYTACLVSALRHVHSQGFVHCDVKARNILVSQSSM 163
Query: 607 VKITDFGISKKLSPLNKQQNKRASL--QGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEM 664
VK+ DFG + ++ RA + +GS WMAPEV+++ ++D+WS+GC I+EM
Sbjct: 164 VKLADFGSAFRI------HTPRALITPRGSPLWMAPEVIRREYQGPESDVWSLGCTIIEM 217
Query: 665 FTGKHPFPDFSQMQAIFKIG-TNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQE 723
FTGK + D + ++ +I ++ +P PS +SE + FL K + D +R S LLQ
Sbjct: 218 FTGKPAWEDHG-IDSLSRISFSDELPVFPSKLSEIGRDFLEKCLKRDPNQRWSCDQLLQH 276
Query: 724 PWLN 727
P+L+
Sbjct: 277 PFLS 280
>YHR102w [T] KOG0201 Serine/threonine protein kinase
Length = 1080
Score = 134 bits (338), Expect = 4e-31
Identities = 93/285 (32%), Positives = 144/285 (49%), Gaps = 40/285 (14%)
Query: 445 IGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKNT 504
IG G FG VY G N +TG + A+K + L S +DE
Sbjct: 29 IGRGKFGVVYKGYNVKTGRVYAIKVLNLD---------SDSDE----------------- 62
Query: 505 SQIHRKMIDALQHEMNILKELHH-ENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNYG 563
++ +Q E+ L L NI YYGS + +L I +E+ GGS+ S+L G
Sbjct: 63 -------VEDVQREIQFLASLKQISNITRYYGSYLKDTSLWIIMEHCAGGSLRSLLRP-G 114
Query: 564 PFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPLNK 623
DE + R++L+ L +HK N+IHRDIK AN+LI +G VK+ DFG++ + +N+
Sbjct: 115 KIDEKYIGVIMRELLVALKCIHKDNVIHRDIKAANVLITNEGNVKLCDFGVA---AQVNQ 171
Query: 624 QQNKRASLQGSVYWMAPEVVKQ-VVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAIFK 682
+R ++ G+ YWMAPEV+ + V K DIWS+G E+ TG P+ D ++A+
Sbjct: 172 TSLRRQTMAGTPYWMAPEVIMEGVYYDTKVDIWSLGITTYEIATGNPPYCDVEALRAMQL 231
Query: 683 IGTNIIPEIPS-WVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
I + P + S K F+ + D ++R S+ LL+ ++
Sbjct: 232 IIKSKPPRLEDRSYSTSLKEFIALCLDEDPKERLSADDLLKSKFI 276
>Hs5454094 [T] KOG0574 STE20-like serine/threonine kinase MST
Length = 491
Score = 134 bits (337), Expect = 5e-31
Identities = 87/286 (30%), Positives = 144/286 (49%), Gaps = 42/286 (14%)
Query: 444 RIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKN 503
++G GS+GSV+ ++ E+G+++A+KQV ++
Sbjct: 32 KLGEGSYGSVFKAIHKESGQVVAIKQVPVESD---------------------------- 63
Query: 504 TSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLN-NY 562
+ + E++I+++ +V YYGS + +L I +EY GSVS ++
Sbjct: 64 --------LQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRN 115
Query: 563 GPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPLN 622
E + + L GL YLH IHRDIK NIL++ +G K+ DFG++ +L+
Sbjct: 116 KTLIEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDT- 174
Query: 623 KQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAIFK 682
KR ++ G+ +WMAPEV++++ ADIWS+G +EM GK P+ D M+AIF
Sbjct: 175 --MAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFM 232
Query: 683 IGTNIIPEI--PSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
I TN P P S++ F+ K + +R ++ LLQ P++
Sbjct: 233 IPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFI 278
>Hs16178962 [T] KOG0574 STE20-like serine/threonine kinase MST
Length = 491
Score = 134 bits (337), Expect = 5e-31
Identities = 87/286 (30%), Positives = 144/286 (49%), Gaps = 42/286 (14%)
Query: 444 RIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKN 503
++G GS+GSV+ ++ E+G+++A+KQV ++
Sbjct: 32 KLGEGSYGSVFKAIHKESGQVVAIKQVPVESD---------------------------- 63
Query: 504 TSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLN-NY 562
+ + E++I+++ +V YYGS + +L I +EY GSVS ++
Sbjct: 64 --------LQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRN 115
Query: 563 GPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPLN 622
E + + L GL YLH IHRDIK NIL++ +G K+ DFG++ +L+
Sbjct: 116 KTLIEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDT- 174
Query: 623 KQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAIFK 682
KR ++ G+ +WMAPEV++++ ADIWS+G +EM GK P+ D M+AIF
Sbjct: 175 --MAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFM 232
Query: 683 IGTNIIPEI--PSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
I TN P P S++ F+ K + +R ++ LLQ P++
Sbjct: 233 IPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFI 278
>Hs22035600 [T] KOG0576 Mitogen-activated protein kinase kinase kinase kinase
(MAP4K) germinal center kinase family
Length = 820
Score = 133 bits (335), Expect = 8e-31
Identities = 91/290 (31%), Positives = 143/290 (48%), Gaps = 46/290 (15%)
Query: 444 RIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKN 503
R+G+G++G VY + T EL AVK V+L P D+
Sbjct: 21 RVGAGTYGDVYKARDTVTSELAAVKIVKLDP----------GDD---------------- 54
Query: 504 TSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNYG 563
I +LQ E+ IL+E H N+V Y GS L I +E+ GGS+ + + G
Sbjct: 55 --------ISSLQQEITILRECRHPNVVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATG 106
Query: 564 PFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPLNK 623
P +E + R+ L GL +LH + IHRDIKGAN+L+ ++G VK+ DFG+S +L+
Sbjct: 107 PLEERQIAYVCREALKGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELT---A 163
Query: 624 QQNKRASLQGSVYWMAPEVV---KQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAI 680
KR S G+ YWMAPEV ++ E D+W++G +E+ + P M+A+
Sbjct: 164 SVAKRRSFIGTPYWMAPEVAAVERKGGYNELCDVWALGITAIELGELQPPLFHLHPMRAL 223
Query: 681 FKIGTNI-----IPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPW 725
+ + + + W ++ FL + + +KRP++ LLQ P+
Sbjct: 224 MLMSKSSFQPPKLRDKTRW-TQNFHHFLKLALTKNPKKRPTAEKLLQHPF 272
>CE28273 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 1096
Score = 133 bits (335), Expect = 8e-31
Identities = 88/301 (29%), Positives = 152/301 (50%), Gaps = 58/301 (19%)
Query: 445 IGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKNT 504
+G+G++G VY G + +T +L A+K +++I ++ +
Sbjct: 27 VGNGTYGQVYKGRHVKTAQLAAIK------------IMNINEDEE--------------- 59
Query: 505 SQIHRKMIDALQHEMNILKE-LHHENIVTYYG--------SSQEGGNLNIFLEYVPGGSV 555
D ++ E+N+LK+ HH N+ TYYG S+ + L + +E+ GS+
Sbjct: 60 --------DEIKLEINMLKKHSHHRNVATYYGAFIKKLPSSTGKHDQLWLVMEFCGSGSI 111
Query: 556 SSMLNNY--GPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFG 613
+ ++ N G E + R+IL GL +LH+ +IHRDIKG N+L+ VK+ DFG
Sbjct: 112 TDLVKNTKGGSLKEEWIAYICREILRGLYHLHQSKVIHRDIKGQNVLLTDSAEVKLVDFG 171
Query: 614 ISKKLSPLNKQQNKRASLQGSVYWMAPEVV-----KQVVTTEKADIWSVGCVIVEMFTGK 668
+S + L+K +R + G+ YWMAPEV+ + ++D+WS+G +EM G
Sbjct: 172 VS---AQLDKTVGRRNTFIGTPYWMAPEVIACDESPEATYDSRSDLWSLGITALEMAEGH 228
Query: 669 HPFPDFSQMQAIFKIGTNIIPEI---PSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPW 725
P D M+A+F I N P++ W +++ + F+ DY +RP + LL+ P+
Sbjct: 229 PPLCDMHPMRALFLIPRNPPPKLKRNKKW-TKKFETFIETVLVKDYHQRPYTGALLRHPF 287
Query: 726 L 726
+
Sbjct: 288 I 288
>CE25673 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 1082
Score = 133 bits (335), Expect = 8e-31
Identities = 88/301 (29%), Positives = 152/301 (50%), Gaps = 58/301 (19%)
Query: 445 IGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKNT 504
+G+G++G VY G + +T +L A+K +++I ++ +
Sbjct: 27 VGNGTYGQVYKGRHVKTAQLAAIK------------IMNINEDEE--------------- 59
Query: 505 SQIHRKMIDALQHEMNILKE-LHHENIVTYYG--------SSQEGGNLNIFLEYVPGGSV 555
D ++ E+N+LK+ HH N+ TYYG S+ + L + +E+ GS+
Sbjct: 60 --------DEIKLEINMLKKHSHHRNVATYYGAFIKKLPSSTGKHDQLWLVMEFCGSGSI 111
Query: 556 SSMLNNY--GPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFG 613
+ ++ N G E + R+IL GL +LH+ +IHRDIKG N+L+ VK+ DFG
Sbjct: 112 TDLVKNTKGGSLKEEWIAYICREILRGLYHLHQSKVIHRDIKGQNVLLTDSAEVKLVDFG 171
Query: 614 ISKKLSPLNKQQNKRASLQGSVYWMAPEVV-----KQVVTTEKADIWSVGCVIVEMFTGK 668
+S + L+K +R + G+ YWMAPEV+ + ++D+WS+G +EM G
Sbjct: 172 VS---AQLDKTVGRRNTFIGTPYWMAPEVIACDESPEATYDSRSDLWSLGITALEMAEGH 228
Query: 669 HPFPDFSQMQAIFKIGTNIIPEI---PSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPW 725
P D M+A+F I N P++ W +++ + F+ DY +RP + LL+ P+
Sbjct: 229 PPLCDMHPMRALFLIPRNPPPKLKRNKKW-TKKFETFIETVLVKDYHQRPYTGALLRHPF 287
Query: 726 L 726
+
Sbjct: 288 I 288
>CE25672 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 1087
Score = 133 bits (335), Expect = 8e-31
Identities = 88/301 (29%), Positives = 152/301 (50%), Gaps = 58/301 (19%)
Query: 445 IGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKNT 504
+G+G++G VY G + +T +L A+K +++I ++ +
Sbjct: 27 VGNGTYGQVYKGRHVKTAQLAAIK------------IMNINEDEE--------------- 59
Query: 505 SQIHRKMIDALQHEMNILKE-LHHENIVTYYG--------SSQEGGNLNIFLEYVPGGSV 555
D ++ E+N+LK+ HH N+ TYYG S+ + L + +E+ GS+
Sbjct: 60 --------DEIKLEINMLKKHSHHRNVATYYGAFIKKLPSSTGKHDQLWLVMEFCGSGSI 111
Query: 556 SSMLNNY--GPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFG 613
+ ++ N G E + R+IL GL +LH+ +IHRDIKG N+L+ VK+ DFG
Sbjct: 112 TDLVKNTKGGSLKEEWIAYICREILRGLYHLHQSKVIHRDIKGQNVLLTDSAEVKLVDFG 171
Query: 614 ISKKLSPLNKQQNKRASLQGSVYWMAPEVV-----KQVVTTEKADIWSVGCVIVEMFTGK 668
+S + L+K +R + G+ YWMAPEV+ + ++D+WS+G +EM G
Sbjct: 172 VS---AQLDKTVGRRNTFIGTPYWMAPEVIACDESPEATYDSRSDLWSLGITALEMAEGH 228
Query: 669 HPFPDFSQMQAIFKIGTNIIPEI---PSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPW 725
P D M+A+F I N P++ W +++ + F+ DY +RP + LL+ P+
Sbjct: 229 PPLCDMHPMRALFLIPRNPPPKLKRNKKW-TKKFETFIETVLVKDYHQRPYTGALLRHPF 287
Query: 726 L 726
+
Sbjct: 288 I 288
>HsM4758524 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 1165
Score = 133 bits (334), Expect = 1e-30
Identities = 91/298 (30%), Positives = 153/298 (50%), Gaps = 55/298 (18%)
Query: 445 IGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKNT 504
+G+G++G VY G + +TG+L A+K V+ + ++ +
Sbjct: 31 VGNGTYGQVYKGRHVKTGQLAAIK------------VMDVTEDEE--------------- 63
Query: 505 SQIHRKMIDALQHEMNILKEL-HHENIVTYYGS----SQEGGNLNIFL--EYVPGGSVSS 557
+ ++ E+N+LK+ HH NI TYYG+ S G + ++L E+ GS++
Sbjct: 64 --------EEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITD 115
Query: 558 MLNNY--GPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGIS 615
++ N E + +R+IL GLA+LH ++IHRDIKG N+L+ VK+ DFG+S
Sbjct: 116 LVKNTKGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVS 175
Query: 616 KKLSPLNKQQNKRASLQGSVYWMAPEVV-----KQVVTTEKADIWSVGCVIVEMFTGKHP 670
+ L++ +R + G+ YWMAPEV+ ++D+WS G +EM G P
Sbjct: 176 ---AQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPP 232
Query: 671 FPDFSQMQAIFKIGTNIIPEIPS--WVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
D M+A+F I N P + S W S++ +F+ +Y +RPS+ LL+ P++
Sbjct: 233 LCDMHPMRALFLIPRNPPPRLKSKKW-SKKFFSFIEGCLVKNYMQRPSTEQLLKHPFI 289
>Hs22035606 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 1212
Score = 133 bits (334), Expect = 1e-30
Identities = 91/298 (30%), Positives = 153/298 (50%), Gaps = 55/298 (18%)
Query: 445 IGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKNT 504
+G+G++G VY G + +TG+L A+K V+ + ++ +
Sbjct: 31 VGNGTYGQVYKGRHVKTGQLAAIK------------VMDVTEDEE--------------- 63
Query: 505 SQIHRKMIDALQHEMNILKEL-HHENIVTYYGS----SQEGGNLNIFL--EYVPGGSVSS 557
+ ++ E+N+LK+ HH NI TYYG+ S G + ++L E+ GS++
Sbjct: 64 --------EEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITD 115
Query: 558 MLNNY--GPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGIS 615
++ N E + +R+IL GLA+LH ++IHRDIKG N+L+ VK+ DFG+S
Sbjct: 116 LVKNTKGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVS 175
Query: 616 KKLSPLNKQQNKRASLQGSVYWMAPEVV-----KQVVTTEKADIWSVGCVIVEMFTGKHP 670
+ L++ +R + G+ YWMAPEV+ ++D+WS G +EM G P
Sbjct: 176 ---AQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPP 232
Query: 671 FPDFSQMQAIFKIGTNIIPEIPS--WVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
D M+A+F I N P + S W S++ +F+ +Y +RPS+ LL+ P++
Sbjct: 233 LCDMHPMRALFLIPRNPPPRLKSKKW-SKKFFSFIEGCLVKNYMQRPSTEQLLKHPFI 289
>Hs22035604 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 1320
Score = 133 bits (334), Expect = 1e-30
Identities = 91/298 (30%), Positives = 153/298 (50%), Gaps = 55/298 (18%)
Query: 445 IGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKNT 504
+G+G++G VY G + +TG+L A+K V+ + ++ +
Sbjct: 31 VGNGTYGQVYKGRHVKTGQLAAIK------------VMDVTEDEE--------------- 63
Query: 505 SQIHRKMIDALQHEMNILKEL-HHENIVTYYGS----SQEGGNLNIFL--EYVPGGSVSS 557
+ ++ E+N+LK+ HH NI TYYG+ S G + ++L E+ GS++
Sbjct: 64 --------EEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITD 115
Query: 558 MLNNY--GPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGIS 615
++ N E + +R+IL GLA+LH ++IHRDIKG N+L+ VK+ DFG+S
Sbjct: 116 LVKNTKGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVS 175
Query: 616 KKLSPLNKQQNKRASLQGSVYWMAPEVV-----KQVVTTEKADIWSVGCVIVEMFTGKHP 670
+ L++ +R + G+ YWMAPEV+ ++D+WS G +EM G P
Sbjct: 176 ---AQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPP 232
Query: 671 FPDFSQMQAIFKIGTNIIPEIPS--WVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
D M+A+F I N P + S W S++ +F+ +Y +RPS+ LL+ P++
Sbjct: 233 LCDMHPMRALFLIPRNPPPRLKSKKW-SKKFFSFIEGCLVKNYMQRPSTEQLLKHPFI 289
>Hs22035602 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 1166
Score = 133 bits (334), Expect = 1e-30
Identities = 91/298 (30%), Positives = 153/298 (50%), Gaps = 55/298 (18%)
Query: 445 IGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKNT 504
+G+G++G VY G + +TG+L A+K V+ + ++ +
Sbjct: 31 VGNGTYGQVYKGRHVKTGQLAAIK------------VMDVTEDEE--------------- 63
Query: 505 SQIHRKMIDALQHEMNILKEL-HHENIVTYYGS----SQEGGNLNIFL--EYVPGGSVSS 557
+ ++ E+N+LK+ HH NI TYYG+ S G + ++L E+ GS++
Sbjct: 64 --------EEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITD 115
Query: 558 MLNNY--GPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGIS 615
++ N E + +R+IL GLA+LH ++IHRDIKG N+L+ VK+ DFG+S
Sbjct: 116 LVKNTKGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVS 175
Query: 616 KKLSPLNKQQNKRASLQGSVYWMAPEVV-----KQVVTTEKADIWSVGCVIVEMFTGKHP 670
+ L++ +R + G+ YWMAPEV+ ++D+WS G +EM G P
Sbjct: 176 ---AQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPP 232
Query: 671 FPDFSQMQAIFKIGTNIIPEIPS--WVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
D M+A+F I N P + S W S++ +F+ +Y +RPS+ LL+ P++
Sbjct: 233 LCDMHPMRALFLIPRNPPPRLKSKKW-SKKFFSFIEGCLVKNYMQRPSTEQLLKHPFI 289
>SPBC17F3.02 [T] KOG0201 Serine/threonine protein kinase
Length = 652
Score = 132 bits (333), Expect = 1e-30
Identities = 93/296 (31%), Positives = 141/296 (47%), Gaps = 41/296 (13%)
Query: 435 APKSWLKGARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSP 494
A + K +G GS+G+VY G+ T E +A+K + L DE +
Sbjct: 6 ASSPYTKLELVGRGSYGAVYRGICNLTKETVAIKILNLD-----------TDEDE----- 49
Query: 495 GGGNTAVKNTSQIHRKMIDALQHEMNILKELHH---ENIVTYYGSSQEGGNLNIFLEYVP 551
+ +Q E+ +L EL ENI+ Y+GS G NL I ++Y
Sbjct: 50 -----------------VSDIQKEVAVLSELKQSDVENIIKYHGSYLVGTNLWIIMDYCH 92
Query: 552 GGSVSSMLNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITD 611
GGSV +++ GP EP + R+ L L ++H IIHRDIK ANIL+ + G VK+ D
Sbjct: 93 GGSVRTLMEA-GPISEPCISLILRETLQALKFIHHAGIIHRDIKAANILVSMSGNVKLCD 151
Query: 612 FGISKKLSPLNKQQNKRASLQGSVYWMAPEVVKQ-VVTTEKADIWSVGCVIVEMFTGKHP 670
FG++ + LN + KR + G+ YWMAPEV++ ADIWS+G E+ TG P
Sbjct: 152 FGVA---AELNINRRKRITFIGTPYWMAPEVIRDGQEYNVMADIWSLGITAYEIATGSPP 208
Query: 671 FPDFSQMQAIFKIGTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
+A++ I P + S K F+ + ++R S LL+ ++
Sbjct: 209 HAKEDPFRAVYLIAHTAPPRLNGNFSALLKEFIASCLQDVPQRRLDSSELLKSKFI 264
>HsM4759010 [T] KOG0576 Mitogen-activated protein kinase kinase kinase kinase
(MAP4K) germinal center kinase family
Length = 819
Score = 132 bits (333), Expect = 1e-30
Identities = 91/290 (31%), Positives = 143/290 (48%), Gaps = 46/290 (15%)
Query: 444 RIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKN 503
R+G+G++G VY + T EL AVK V+L P D+
Sbjct: 20 RVGAGTYGDVYKARDTVTSELAAVKIVKLDP----------GDD---------------- 53
Query: 504 TSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNYG 563
I +LQ E+ IL+E H N+V Y GS L I +E+ GGS+ + + G
Sbjct: 54 --------ISSLQQEITILRECRHPNVVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATG 105
Query: 564 PFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPLNK 623
P +E + R+ L GL +LH + IHRDIKGAN+L+ ++G VK+ DFG+S +L+
Sbjct: 106 PLEERQIAYVCRERLKGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELT---A 162
Query: 624 QQNKRASLQGSVYWMAPEVV---KQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAI 680
KR S G+ YWMAPEV ++ E D+W++G +E+ + P M+A+
Sbjct: 163 SVAKRRSFIGTPYWMAPEVAAVERKGGYNELCDVWALGITAIELGELQPPLFHLHPMRAL 222
Query: 681 FKIGTNI-----IPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPW 725
+ + + + W ++ FL + + +KRP++ LLQ P+
Sbjct: 223 MLMSKSSFQPPKLRDKTRW-TQNFHHFLKLALTKNPKKRPTAEKLLQHPF 271
>7302511 [T] KOG0576 Mitogen-activated protein kinase kinase kinase kinase
(MAP4K) germinal center kinase family
Length = 1218
Score = 132 bits (332), Expect = 2e-30
Identities = 89/291 (30%), Positives = 141/291 (47%), Gaps = 46/291 (15%)
Query: 444 RIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKN 503
+IGSG++G VY ++ EL A+K ++L+P+ D+
Sbjct: 31 KIGSGTYGDVYKAKRIQSNELAAIKVIKLEPS----------DD---------------- 64
Query: 504 TSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNYG 563
I +Q E+ ++++ H NI+ YYGS L I +E+ GGS+ + G
Sbjct: 65 --------IQIIQQEIIMMRDCRHPNIIAYYGSYLRRDKLWICMEFCGGGSLQDIYQVTG 116
Query: 564 PFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPLNK 623
P E + R+ L GL YLH +HRDIKGANIL+ G VK+ DFG+S +++
Sbjct: 117 PLTEVQIAYMCRETLKGLEYLHSMGKMHRDIKGANILLTEYGDVKLADFGVSAQIT---A 173
Query: 624 QQNKRASLQGSVYWMAPEVV---KQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAI 680
NKR S G+ YWMAPEV ++ + DIW+ G +E+ + P D M+A+
Sbjct: 174 TINKRKSFIGTPYWMAPEVAAVERKGGYNQLCDIWACGITAIELAELQPPMFDLHPMRAL 233
Query: 681 FKIGTN-----IIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
F + + + W S F+ + + +KRP++ LLQ P++
Sbjct: 234 FLMSKSGFKPPTLNNKDKW-SPTFHNFIKTALTKNPKKRPTAERLLQHPFV 283
>YOL113w [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 655
Score = 132 bits (331), Expect = 2e-30
Identities = 80/248 (32%), Positives = 137/248 (54%), Gaps = 15/248 (6%)
Query: 492 HSPGGGNTAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQ-EGGNLNIFLEYV 550
H G A+K + + +E+ ++ + ENIV + + + L + +EY+
Sbjct: 396 HRVVGERVAIKQIRLSEQPKKQLIMNELLVMNDSRQENIVNFLEAYIIDDEELWVIMEYM 455
Query: 551 PGGSVSSMLN-----NYGPFDEPLVKN----FTRQILIGLAYLHKRNIIHRDIKGANILI 601
GG ++ +L+ N G PL +N ++ GL +LH + IIHRDIK NIL+
Sbjct: 456 EGGCLTDILDAVARSNTGEHSSPLNENQMAYIVKETCQGLKFLHNKKIIHRDIKSDNILL 515
Query: 602 DIKGGVKITDFGISKKLSPLNKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVI 661
+ +G VKITDFG +L+ ++++KRA++ G+ YWMAPE+V Q EK D+WS+G ++
Sbjct: 516 NSQGLVKITDFGFCVELT---EKRSKRATMVGTPYWMAPEIVNQKGYDEKVDVWSLGIML 572
Query: 662 VEMFTGKHPFPDFSQMQAIFKIGTNIIPEI--PSWVSEEAKAFLFKSFELDYRKRPSSLG 719
+EM G+ P+ + ++A++ I N P++ P VS++ K FL +++ R S
Sbjct: 573 IEMIEGEPPYLNEDPLKALYLIANNGSPKLRHPESVSKQTKQFLDACLQVNVESRASVRK 632
Query: 720 LLQEPWLN 727
LL +L+
Sbjct: 633 LLTFEFLS 640
>7300149 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 569
Score = 131 bits (330), Expect = 3e-30
Identities = 77/253 (30%), Positives = 138/253 (54%), Gaps = 14/253 (5%)
Query: 479 AGVVSIADESKKAHSPGGGNTAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSS- 537
+G+V IA + + AVK ++ D + E+ +LK+ +H+N+V + +
Sbjct: 304 SGIVFIAADLQNE-----SQVAVKTIDMKNQSSKDLILTEIRVLKDFNHKNLVNFLDAYL 358
Query: 538 -QEGGNLNIFLEYVPGGSVSSMLNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKG 596
+ L + +EY+ GG ++ ++ E + R+ L +++LH + IIHRDIK
Sbjct: 359 LEPEDQLWVVMEYMDGGPLTDVVTET-VMKERQIACVCRETLYAISFLHAKGIIHRDIKS 417
Query: 597 ANILIDIKGGVKITDFGISKKLSPLNKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWS 656
N+L+ + G VK+TDFG + + KR ++ G+ YWMAPEVV + +K DIWS
Sbjct: 418 DNVLLGMDGSVKVTDFGFCANI----EGDEKRQTMVGTPYWMAPEVVTRKKYGKKVDIWS 473
Query: 657 VGCVIVEMFTGKHPFPDFSQMQAIFKIGTNIIPEIPSW--VSEEAKAFLFKSFELDYRKR 714
+G + +EM G+ P+ + ++A++ I N P+I SW +S + FL + +++ +R
Sbjct: 474 IGIMAIEMIEGQPPYLYETPLRALYLIAANGRPDIKSWDKLSPNLQDFLDRCLQVEVDRR 533
Query: 715 PSSLGLLQEPWLN 727
++ LL P+LN
Sbjct: 534 ATADELLSHPFLN 546
>Hs7657335 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 1295
Score = 131 bits (329), Expect = 4e-30
Identities = 92/298 (30%), Positives = 148/298 (48%), Gaps = 55/298 (18%)
Query: 445 IGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKNT 504
+G+G++G VY G + +TG+L A+K V+ + ++ +
Sbjct: 31 VGNGTYGQVYKGRHVKTGQLAAIK------------VMDVTEDEE--------------- 63
Query: 505 SQIHRKMIDALQHEMNILKEL-HHENIVTYYGS----SQEGGNLNIFL--EYVPGGSVSS 557
+ ++ E+N+LK+ HH NI TYYG+ S G + ++L E+ GSV+
Sbjct: 64 --------EEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTD 115
Query: 558 MLNNY--GPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGIS 615
++ N E + R+IL GLA+LH +IHRDIKG N+L+ VK+ DFG+S
Sbjct: 116 LVKNTKGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVS 175
Query: 616 KKLSPLNKQQNKRASLQGSVYWMAPEVV-----KQVVTTEKADIWSVGCVIVEMFTGKHP 670
+ L++ +R + G+ YWMAPEV+ ++DIWS+G +EM G P
Sbjct: 176 ---AQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPP 232
Query: 671 FPDFSQMQAIFKIGTNIIPEIPS--WVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
D M+A+F I N P + S W S++ F+ Y RP + LL+ P++
Sbjct: 233 LCDMHPMRALFLIPRNPPPRLKSKKW-SKKFIDFIDTCLIKTYLSRPPTEQLLKFPFI 289
>Hs14771959 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 719
Score = 130 bits (328), Expect = 5e-30
Identities = 78/251 (31%), Positives = 138/251 (54%), Gaps = 11/251 (4%)
Query: 478 TAGVVSIADESKKAHSPGGGNTAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSS 537
+ G+V IA E G AVK ++ + L +E+ I+++ HH+N+V Y S
Sbjct: 459 STGIVCIATEKHT-----GKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVDMYSSY 513
Query: 538 QEGGNLNIFLEYVPGGSVSSMLNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGA 597
G L + +E++ GG+++ ++ + +E + +L L+YLH + +IHRDIK
Sbjct: 514 LVGDELWVVMEFLEGGALTDIVT-HTRMNEEQIATVCLSVLRALSYLHNQGVIHRDIKSD 572
Query: 598 NILIDIKGGVKITDFGISKKLSPLNKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSV 657
+IL+ G +K++DFG ++S K+ KR SL G+ YWMAPEV+ ++ + DIWS+
Sbjct: 573 SILLTSDGRIKLSDFGFCAQVS---KEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSL 629
Query: 658 GCVIVEMFTGKHPFPDFSQMQAIFKIGTNIIPEIPSW--VSEEAKAFLFKSFELDYRKRP 715
G +++EM G+ P+ + +QA+ +I ++ P + VS + FL + +R
Sbjct: 630 GIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPPRVKDLHKVSSVLRGFLDLMLVREPSQRA 689
Query: 716 SSLGLLQEPWL 726
++ LL P+L
Sbjct: 690 TAQELLGHPFL 700
>At3g61960 [OUT] KOG0595 Serine/threonine-protein kinase involved in autophagy
Length = 648
Score = 130 bits (327), Expect = 7e-30
Identities = 77/245 (31%), Positives = 128/245 (51%), Gaps = 39/245 (15%)
Query: 442 GARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAV 501
G RIGSGSF V+L + +G +AVK+++ KK SP
Sbjct: 13 GPRIGSGSFAVVWLAKHRSSGLEVAVKEID-----------------KKLLSP------- 48
Query: 502 KNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNN 561
K+ D L E++IL + H NI+ +Y + + G + + LEY GG ++ +N
Sbjct: 49 --------KVRDNLLKEISILSTIDHPNIIRFYEAIETGDRIFLVLEYCSGGDLAGYINR 100
Query: 562 YGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILI---DIKGGVKITDFGISKKL 618
+G E + K+F RQ+ +GL L +++ IHRD+K N+L+ ++ +KI DFG ++ L
Sbjct: 101 HGKVPEAVAKHFMRQLALGLQVLQEKHFIHRDLKPQNLLLSSKEVTPLLKIGDFGFARSL 160
Query: 619 SPLNKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQ 678
+P ++ + GS +MAPE+++ KAD+WS G ++ ++ TGK PF + +Q
Sbjct: 161 TP----ESMAETFCGSPLYMAPEIIRNQKYDAKADLWSAGAILFQLVTGKPPFDGNNHIQ 216
Query: 679 AIFKI 683
I
Sbjct: 217 LFHNI 221
>At1g05100 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 339
Score = 130 bits (327), Expect = 7e-30
Identities = 91/304 (29%), Positives = 149/304 (48%), Gaps = 57/304 (18%)
Query: 438 SWLKGARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGG 497
+W +G +G GS +V E+GE +AVK E
Sbjct: 2 NWTRGKTLGRGSTATVSAATCHESGETLAVKSAEF------------------------- 36
Query: 498 NTAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYG---------SSQEGGNLNIFLE 548
HR + LQ E IL L+ ++ Y G ++ E ++ +E
Sbjct: 37 ----------HRS--EFLQREAKILSSLNSPYVIGYRGCEITREPFHNNGEATTYSLLME 84
Query: 549 YVPGGSVSSMLNNYGPF-DEPLVKNFTRQILIGLAYLHK-RNIIHRDIKGANILIDIKGG 606
Y P G+++ + G F DE V +TRQIL+GL Y+H + I H DIKG+N+L+ G
Sbjct: 85 YAPYGTLTDVATKNGGFIDEARVVKYTRQILLGLEYIHNSKGIAHCDIKGSNVLVGENGE 144
Query: 607 VKITDFGISKKLSPLNKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFT 666
KI DFG +K + P + ++G+ +MAPE + +++DIW+VGC ++EM T
Sbjct: 145 AKIADFGCAKWVEPEITEP-----VRGTPAFMAPEAARGERQGKESDIWAVGCTVIEMVT 199
Query: 667 GKHPF--PDFSQ-MQAIFKIG-TNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQ 722
G P+ DF+ + ++++G +PE+P ++E+AK FL K + + +R ++ LL
Sbjct: 200 GSQPWIGADFTDPVSVLYRVGYLGELPELPCSLTEQAKDFLGKCLKKEATERWTASQLLN 259
Query: 723 EPWL 726
P+L
Sbjct: 260 HPFL 263
>Hs9910476 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 681
Score = 129 bits (324), Expect = 2e-29
Identities = 81/251 (32%), Positives = 141/251 (55%), Gaps = 11/251 (4%)
Query: 478 TAGVVSIADESKKAHSPGGGNTAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSS 537
+ G+V +A E HS G AVK ++ + L +E+ I+++ H N+V Y S
Sbjct: 417 STGIVCLAREK---HS--GRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSY 471
Query: 538 QEGGNLNIFLEYVPGGSVSSMLNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGA 597
G L + +E++ GG+++ +++ +E + +L LAYLH + +IHRDIK
Sbjct: 472 LVGEELWVLMEFLQGGALTDIVSQVR-LNEEQIATVCEAVLQALAYLHAQGVIHRDIKSD 530
Query: 598 NILIDIKGGVKITDFGISKKLSPLNKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSV 657
+IL+ + G VK++DFG ++S K KR SL G+ YWMAPEV+ + + + DIWS+
Sbjct: 531 SILLTLDGRVKLSDFGFCAQIS---KDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSL 587
Query: 658 GCVIVEMFTGKHPFPDFSQMQAIFKIGTNIIPEIPS--WVSEEAKAFLFKSFELDYRKRP 715
G +++EM G+ P+ S +QA+ ++ + P++ + VS + FL + D ++R
Sbjct: 588 GIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQERA 647
Query: 716 SSLGLLQEPWL 726
++ LL P+L
Sbjct: 648 TAQELLDHPFL 658
>7291778 [T] KOG0579 Ste20-like serine/threonine protein kinase
Length = 1726
Score = 129 bits (324), Expect = 2e-29
Identities = 90/298 (30%), Positives = 141/298 (47%), Gaps = 47/298 (15%)
Query: 439 WLKGARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGN 498
W +G G+FG VY + E A K +L+ +E+ H
Sbjct: 37 WEMVGELGDGAFGKVYKAQHKEQKRFAAAKMCQLED-----------EENLSDHMV---- 81
Query: 499 TAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSS- 557
E++IL E+ H NIV Y + L + +EY GG++ S
Sbjct: 82 -------------------EIDILSEIKHPNIVELYEAFSIDDKLWMLIEYCDGGALDSI 122
Query: 558 MLNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKK 617
M+ P EP + + + GL +LH+ +IHRD+K N+L+ ++GGVK+ DFG+S K
Sbjct: 123 MVELEKPLTEPQIAYVCKHMTEGLTFLHRNKVIHRDLKAGNVLLTMEGGVKLADFGVSAK 182
Query: 618 LSPLNKQ-QNKRASLQGSVYWMAPEVV-----KQVVTTEKADIWSVGCVIVEMFTGKHPF 671
NK K + G+ YWMAPE+V + K DIWS+G ++E+ + P
Sbjct: 183 ----NKHTMQKHDTFIGTPYWMAPELVLCETFRDNPYDHKVDIWSLGITLIELAQMEPPN 238
Query: 672 PDFSQMQAIFKIGTNIIPEI--PSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWLN 727
+ S M+ + KI + P++ PS S+E FL KS D + RP++ L+Q ++N
Sbjct: 239 SEMSPMRVLLKIQKSEPPKLEQPSRWSKEFNDFLKKSLVKDPQVRPTTDVLMQHAFIN 296
>Hs20428779_1 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 357
Score = 129 bits (324), Expect = 2e-29
Identities = 100/319 (31%), Positives = 150/319 (46%), Gaps = 58/319 (18%)
Query: 428 SLPTKVEAPKSWLKGARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADE 487
SLP + +W IG G++G VY N G L AVK ++ VS DE
Sbjct: 19 SLPDPTD---TWEIIETIGKGTYGKVYKVTNKRDGSLAAVKILD---------PVSDMDE 66
Query: 488 SKKAHSPGGGNTAVKNTSQIHRKMIDALQHEMNILKEL-HHENIVTYYGSSQE-----GG 541
+A E NIL+ L +H N+V +YG + GG
Sbjct: 67 EIEA--------------------------EYNILQFLPNHPNVVKFYGMFYKADHCVGG 100
Query: 542 NLNIFLEYVPGGSVSSMLNNY----GPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGA 597
L + LE GGSV+ ++ DE ++ L+GL +LH IIHRD+KG
Sbjct: 101 QLWLVLELCNGGSVTELVKGLLRCGQRLDEAMISYILYGALLGLQHLHNNRIIHRDVKGN 160
Query: 598 NILIDIKGGVKITDFGISKKLSPLNKQQNKRASLQGSVYWMAPEVV---KQVVTT--EKA 652
NIL+ +GGVK+ DFG+S +L+ ++N G+ +WMAPEV+ +Q ++ +
Sbjct: 161 NILLTTEGGVKLVDFGVSAQLTSTRLRRNTSV---GTPFWMAPEVIACEQQYDSSYDARC 217
Query: 653 DIWSVGCVIVEMFTGKHPFPDFSQMQAIFKIGTNIIPEI--PSWVSEEAKAFLFKSFELD 710
D+WS+G +E+ G P D ++ +FKI N P + P EE F+ + D
Sbjct: 218 DVWSLGITAIELGDGDPPLFDMHPVKTLFKIPRNPPPTLLHPEKWCEEFNHFISQCLIKD 277
Query: 711 YRKRPSSLGLLQEPWLNTV 729
+ +RPS LL P++ V
Sbjct: 278 FERRPSVTHLLDHPFIKGV 296
>CE27965 [T] KOG0574 STE20-like serine/threonine kinase MST
Length = 525
Score = 129 bits (323), Expect = 2e-29
Identities = 84/286 (29%), Positives = 139/286 (48%), Gaps = 42/286 (14%)
Query: 444 RIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKN 503
++G GS+GSV+ ++ E+G ++A+K+V +
Sbjct: 68 KLGEGSYGSVHKAIHRESGHVLAIKKVPVDTD---------------------------- 99
Query: 504 TSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLN-NY 562
+ + E++I+++ + +V YYGS + +L I +EY GS+S ++
Sbjct: 100 --------LQEIIKEISIMQQCKSKYVVKYYGSYFKHSDLWIVMEYCGAGSISDIMRARR 151
Query: 563 GPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPLN 622
P E + R L GL YLH IHRDIK NIL++ G K+ DFG++ +L+
Sbjct: 152 KPLSEQEISAVLRDTLKGLQYLHDLKKIHRDIKAGNILLNTDGIAKLADFGVAGQLTDT- 210
Query: 623 KQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAIFK 682
KR ++ G+ +WMAPEV++++ KADIWS+G +EM G+ P+ D M+AIF
Sbjct: 211 --MAKRNTVIGTPFWMAPEVIEEIGYDTKADIWSLGITAIEMAEGRPPYSDIHPMRAIFM 268
Query: 683 IGTNIIPEI--PSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
I T P P S E F+ +R ++L L + ++
Sbjct: 269 IPTKPPPTFKKPEEWSSEFNDFIRSCLIKKPEERKTALRLCEHTFI 314
>CE27726 [T] KOG0574 STE20-like serine/threonine kinase MST
Length = 640
Score = 129 bits (323), Expect = 2e-29
Identities = 84/286 (29%), Positives = 139/286 (48%), Gaps = 42/286 (14%)
Query: 444 RIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKN 503
++G GS+GSV+ ++ E+G ++A+K+V +
Sbjct: 40 KLGEGSYGSVHKAIHRESGHVLAIKKVPVDTD---------------------------- 71
Query: 504 TSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLN-NY 562
+ + E++I+++ + +V YYGS + +L I +EY GS+S ++
Sbjct: 72 --------LQEIIKEISIMQQCKSKYVVKYYGSYFKHSDLWIVMEYCGAGSISDIMRARR 123
Query: 563 GPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPLN 622
P E + R L GL YLH IHRDIK NIL++ G K+ DFG++ +L+
Sbjct: 124 KPLSEQEISAVLRDTLKGLQYLHDLKKIHRDIKAGNILLNTDGIAKLADFGVAGQLTDT- 182
Query: 623 KQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAIFK 682
KR ++ G+ +WMAPEV++++ KADIWS+G +EM G+ P+ D M+AIF
Sbjct: 183 --MAKRNTVIGTPFWMAPEVIEEIGYDTKADIWSLGITAIEMAEGRPPYSDIHPMRAIFM 240
Query: 683 IGTNIIPEI--PSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
I T P P S E F+ +R ++L L + ++
Sbjct: 241 IPTKPPPTFKKPEEWSSEFNDFIRSCLIKKPEERKTALRLCEHTFI 286
>CE27082 [T] KOG0574 STE20-like serine/threonine kinase MST
Length = 421
Score = 129 bits (323), Expect = 2e-29
Identities = 84/286 (29%), Positives = 139/286 (48%), Gaps = 42/286 (14%)
Query: 444 RIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKN 503
++G GS+GSV+ ++ E+G ++A+K+V +
Sbjct: 40 KLGEGSYGSVHKAIHRESGHVLAIKKVPVDTD---------------------------- 71
Query: 504 TSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLN-NY 562
+ + E++I+++ + +V YYGS + +L I +EY GS+S ++
Sbjct: 72 --------LQEIIKEISIMQQCKSKYVVKYYGSYFKHSDLWIVMEYCGAGSISDIMRARR 123
Query: 563 GPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPLN 622
P E + R L GL YLH IHRDIK NIL++ G K+ DFG++ +L+
Sbjct: 124 KPLSEQEISAVLRDTLKGLQYLHDLKKIHRDIKAGNILLNTDGIAKLADFGVAGQLTDT- 182
Query: 623 KQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAIFK 682
KR ++ G+ +WMAPEV++++ KADIWS+G +EM G+ P+ D M+AIF
Sbjct: 183 --MAKRNTVIGTPFWMAPEVIEEIGYDTKADIWSLGITAIEMAEGRPPYSDIHPMRAIFM 240
Query: 683 IGTNIIPEI--PSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
I T P P S E F+ +R ++L L + ++
Sbjct: 241 IPTKPPPTFKKPEEWSSEFNDFIRSCLIKKPEERKTALRLCEHTFI 286
>CE07064 [T] KOG0574 STE20-like serine/threonine kinase MST
Length = 523
Score = 129 bits (323), Expect = 2e-29
Identities = 84/286 (29%), Positives = 139/286 (48%), Gaps = 42/286 (14%)
Query: 444 RIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKN 503
++G GS+GSV+ ++ E+G ++A+K+V +
Sbjct: 68 KLGEGSYGSVHKAIHRESGHVLAIKKVPVDTD---------------------------- 99
Query: 504 TSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLN-NY 562
+ + E++I+++ + +V YYGS + +L I +EY GS+S ++
Sbjct: 100 --------LQEIIKEISIMQQCKSKYVVKYYGSYFKHSDLWIVMEYCGAGSISDIMRARR 151
Query: 563 GPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPLN 622
P E + R L GL YLH IHRDIK NIL++ G K+ DFG++ +L+
Sbjct: 152 KPLSEQEISAVLRDTLKGLQYLHDLKKIHRDIKAGNILLNTDGIAKLADFGVAGQLTDT- 210
Query: 623 KQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAIFK 682
KR ++ G+ +WMAPEV++++ KADIWS+G +EM G+ P+ D M+AIF
Sbjct: 211 --MAKRNTVIGTPFWMAPEVIEEIGYDTKADIWSLGITAIEMAEGRPPYSDIHPMRAIFM 268
Query: 683 IGTNIIPEI--PSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
I T P P S E F+ +R ++L L + ++
Sbjct: 269 IPTKPPPTFKKPEEWSSEFNDFIRSCLIKKPEERKTALRLCEHTFI 314
>Hs18602554 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 227
Score = 128 bits (322), Expect = 3e-29
Identities = 74/207 (35%), Positives = 121/207 (57%), Gaps = 6/207 (2%)
Query: 522 LKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNYGPFDEPLVKNFTRQILIGL 581
+KEL + NIV + S G L + +EY+ GS++ ++ DE + R+ L L
Sbjct: 1 MKELKNPNIVNFLDSYLVGDELFVVVEYLARGSLTDVVTETC-MDEAQIAAVCRESLQAL 59
Query: 582 AYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPLNKQQNKRASLQGSVYWMAPE 641
+LH +IHRDIK ++L+ ++G VK+TDFG +++P +Q+KR+++ + YWMAPE
Sbjct: 60 EFLHANQVIHRDIKSDSVLLGMEGSVKLTDFGFCAQITP---EQSKRSTVVRTPYWMAPE 116
Query: 642 VVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAIFKIGTNIIPEI--PSWVSEEA 699
VV + K ++WS+G + EM G+ P+ + + ++A+ I TN IPE+ P +S
Sbjct: 117 VVTRKAYGPKVNVWSLGIMATEMVEGEPPYLNENPLRALCLIATNGIPELQNPETLSPIF 176
Query: 700 KAFLFKSFELDYRKRPSSLGLLQEPWL 726
+ FL + E D KR S+ LLQ +L
Sbjct: 177 RDFLNRCLETDVEKRGSAKELLQHLFL 203
>7292249 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 979
Score = 128 bits (321), Expect = 4e-29
Identities = 87/298 (29%), Positives = 147/298 (49%), Gaps = 55/298 (18%)
Query: 445 IGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKNT 504
+G+G++G VY G + +TG+L A+K V+ + ++ +
Sbjct: 38 VGNGTYGQVYKGRHTKTGQLAAIK------------VMDVTEDEE--------------- 70
Query: 505 SQIHRKMIDALQHEMNILKEL-HHENIVTYYGS------SQEGGNLNIFLEYVPGGSVSS 557
+ ++ E+N+LK+ +H NI TYYG+ + L + +EY GSV+
Sbjct: 71 --------EEIKLEINVLKKYSNHRNIATYYGAFIKKSPPGKDDQLWLVMEYCGAGSVTD 122
Query: 558 MLNNYG--PFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGIS 615
++ + E + R+IL GL+YLH +IHRDIKG N+L+ VK+ DFG+S
Sbjct: 123 LVKSTKGQSLKEEWIAYICREILRGLSYLHSNKVIHRDIKGQNVLLTDNAEVKLVDFGVS 182
Query: 616 KKLSPLNKQQNKRASLQGSVYWMAPEVV-----KQVVTTEKADIWSVGCVIVEMFTGKHP 670
+ L++ +R + G+ YWMAPEV+ ++D+WS+G +EM + P
Sbjct: 183 ---AQLDRTIGRRNTFIGTPYWMAPEVIACDENPDATYDNRSDLWSLGITALEMAESQPP 239
Query: 671 FPDFSQMQAIFKIGTNIIPEIPS--WVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
D M+A+F I N P + S W S++ F+ DY +RP + LL+ ++
Sbjct: 240 LCDLHPMRALFLIPRNSPPRLKSKKW-SKKFHGFIDTVLVKDYHQRPYTENLLKHGFI 296
>Hs5031975 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 591
Score = 127 bits (319), Expect = 6e-29
Identities = 86/294 (29%), Positives = 154/294 (52%), Gaps = 41/294 (13%)
Query: 436 PKSWLKG-ARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSP 494
P+S+L +IG GS G V + +G+L+AVK+++L+
Sbjct: 317 PRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLR--------------------- 355
Query: 495 GGGNTAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGS 554
Q R++ L +E+ I+++ HEN+V Y S G L + +E++ GG+
Sbjct: 356 ----------KQQRREL---LFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGA 402
Query: 555 VSSMLNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGI 614
++ ++ + +E + +L L+ LH + +IHRDIK +IL+ G VK++DFG
Sbjct: 403 LTDIVT-HTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGF 461
Query: 615 SKKLSPLNKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDF 674
++S K+ +R SL G+ YWMAPE++ ++ + DIWS+G +++EM G+ P+ +
Sbjct: 462 CAQVS---KEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNE 518
Query: 675 SQMQAIFKIGTNIIPEIPSW--VSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
++A+ I N+ P + + VS K FL + D +R ++ LL+ P+L
Sbjct: 519 PPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFL 572
>At1g69220 [T] KOG0576 Mitogen-activated protein kinase kinase kinase kinase
(MAP4K) germinal center kinase family
Length = 836
Score = 127 bits (319), Expect = 6e-29
Identities = 86/286 (30%), Positives = 143/286 (49%), Gaps = 41/286 (14%)
Query: 445 IGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKNT 504
+G GS+GSVY + +T E++AVK + L E ++ +
Sbjct: 255 LGKGSYGSVYKARDLKTSEIVAVKVISLT-------------EGEEGY------------ 289
Query: 505 SQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLN-NYG 563
+ ++ E+ +L++ +H N+V Y GS Q L I +EY GGSV+ ++N
Sbjct: 290 --------EEIRGEIEMLQQCNHPNVVRYLGSYQGEDYLWIVMEYCGGGSVADLMNVTEE 341
Query: 564 PFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPLNK 623
+E + R+ L GLAYLH +HRDIKG NIL+ +G VK+ DFG++ +L+ +
Sbjct: 342 ALEEYQIAYICREALKGLAYLHSIYKVHRDIKGGNILLTEQGEVKLGDFGVAAQLT---R 398
Query: 624 QQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAIFKI 683
+KR + G+ +WMAPEV+++ K D+W++G +EM G P M+ +F I
Sbjct: 399 TMSKRNTFIGTPHWMAPEVIQENRYDGKVDVWALGVSAIEMAEGLPPRSSVHPMRVLFMI 458
Query: 684 GTNIIPEI---PSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
P + W S F+ K + R RP++ +L+ ++
Sbjct: 459 SIEPAPMLEDKEKW-SLVFHDFVAKCLTKEPRLRPTAAEMLKHKFV 503
>SPCC18B5.11c [D] KOG0615 Serine/threonine protein kinase Chk2 and related
proteins
Length = 460
Score = 127 bits (318), Expect = 8e-29
Identities = 89/294 (30%), Positives = 137/294 (46%), Gaps = 39/294 (13%)
Query: 445 IGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKNT 504
+GSG+F V L + +G+ A+K + + +T+
Sbjct: 173 LGSGTFAVVKLAVEVNSGKWYAIKIINKRKILLTSS------------------------ 208
Query: 505 SQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNYGP 564
++ + Q E++ILK LHH +V + + L I +EYV GG + L G
Sbjct: 209 ---EKRATEMFQREIDILKSLHHPGVVQCHEIFENDDELFIVMEYVEGGDLMDFLIANGS 265
Query: 565 FDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPLNKQ 624
DE K +Q+L L +LHK+ + HRDIK NILI +KI+DFG++K ++
Sbjct: 266 IDEQDCKPLLKQLLETLLHLHKQGVTHRDIKPENILITNDFHLKISDFGLAK---VIHGT 322
Query: 625 QNKRASLQGSVYWMAPEVVKQVVTT------EKADIWSVGCVIVEMFTGKHPFPDFSQMQ 678
+ G++ ++APEV+K +K DIWS+GCV+ M T PF SQ +
Sbjct: 323 GTFLETFCGTMGYLAPEVLKSKNVNLDGGYDDKVDIWSLGCVLYVMLTASIPFASSSQAK 382
Query: 679 AIFKIGTN---IIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWLNTV 729
I I I P + + +SEE + + E++ KR S LQ PW TV
Sbjct: 383 CIELISKGAYPIEPLLENEISEEGIDLINRMLEINPEKRISESEALQHPWFYTV 436
>Hs7661994 [T] KOG0579 Ste20-like serine/threonine protein kinase
Length = 1152
Score = 126 bits (317), Expect = 1e-28
Identities = 92/296 (31%), Positives = 137/296 (46%), Gaps = 45/296 (15%)
Query: 439 WLKGARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGN 498
W +G G+FG VY N ET L A K ++
Sbjct: 34 WEIIGELGDGAFGKVYKAQNKETSVLAAAKVID--------------------------- 66
Query: 499 TAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSS- 557
K+ ++ M+ E++IL H NIV + NL I +E+ GG+V +
Sbjct: 67 --TKSEEELEDYMV-----EIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAV 119
Query: 558 MLNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKK 617
ML P E ++ +Q L L YLH IIHRD+K NIL + G +K+ DFG+S K
Sbjct: 120 MLELERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAK 179
Query: 618 LSPLNKQQNKRASLQGSVYWMAPEVVKQVVTTE-----KADIWSVGCVIVEMFTGKHPFP 672
+ + +R S G+ YWMAPEVV + + KAD+WS+G ++EM + P
Sbjct: 180 NT---RTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHH 236
Query: 673 DFSQMQAIFKIGTNIIPEI--PSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
+ + M+ + KI + P + PS S K FL K E + R ++ LLQ P++
Sbjct: 237 ELNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFV 292
>At2g30040 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 463
Score = 126 bits (316), Expect = 1e-28
Identities = 92/297 (30%), Positives = 151/297 (49%), Gaps = 50/297 (16%)
Query: 438 SWLKGARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGG 497
SW++G+ +G G FG+V ++ G L AVK ++L +
Sbjct: 16 SWIRGSCVGRGCFGTVSKALSKIDGGLFAVKSIDLATCLPSQA----------------- 58
Query: 498 NTAVKNTSQIHRKMIDALQHEMNILKELH-HENIVTYYGS--SQEG--GNLNIFLEYVPG 552
++L++E+ IL+ + H NIV + G S+EG N+ LEY P
Sbjct: 59 ---------------ESLENEIVILRSMKSHPNIVRFLGDDVSKEGTASFRNLHLEYSPE 103
Query: 553 GSVSSMLNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGG--VKIT 610
G V+ N G +E L++ + ++ L+++H I+H D+K N+L+ GG VK+
Sbjct: 104 GDVA----NGGIVNETLLRRYVWCLVSALSHVHSNGIVHCDVKSKNVLV-FNGGSSVKLA 158
Query: 611 DFGISKKLSPLNKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHP 670
DFG + + ++ S +GS WMAPEVV++ ++D+WS+GC ++EM TGK
Sbjct: 159 DFGSAVEF----EKSTIHVSPRGSPLWMAPEVVRREYQGPESDVWSLGCTVIEMLTGKPA 214
Query: 671 FPDFSQMQAIFKIG-TNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
+ D ++ +IG +N +P IP +SE + FL K + D +R S LLQ P+L
Sbjct: 215 WEDHG-FDSLSRIGFSNDLPFIPVGLSELGRDFLEKCLKRDRSQRWSCDQLLQHPFL 270
>SPBC4F6.06 [T] KOG0583 Serine/threonine protein kinase
Length = 891
Score = 125 bits (315), Expect = 2e-28
Identities = 91/293 (31%), Positives = 140/293 (47%), Gaps = 25/293 (8%)
Query: 438 SWLKGARIGSGSFGSVYLGMNAETGELMAVKQV-ELKPTAVTAGVVSIADESKKAHSPGG 496
+++ G IG+GS G V + + +TGE A+K V L P A + A+ +K A S
Sbjct: 124 NYVLGKTIGAGSMGKVKVAHHLKTGEQFAIKIVTRLHPDITKAKAAASAEATKAAQSEKN 183
Query: 497 GNTAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVS 556
K + + L L H I + + E+V GG +
Sbjct: 184 -----KEIRTVREAALSTL---------LRHPYICEARDVYITNSHYYMVFEFVDGGQML 229
Query: 557 SMLNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISK 616
+ ++G E + F RQI L+YLH+ +++HRD+K NILI G +KI DFG
Sbjct: 230 DYIISHGKLKEKQARKFVRQIGSALSYLHQNSVVHRDLKIENILISKTGDIKIIDFG--- 286
Query: 617 KLSPLNKQQNKRASLQGSVYWMAPEVVK-QVVTTEKADIWSVGCVIVEMFTGKHPFPD-- 673
LS L ++Q++ + GS+Y+ APE++ Q + D+WS G V+ + GK PF D
Sbjct: 287 -LSNLYRRQSRLRTFCGSLYFAAPELLNAQPYIGPEVDVWSFGIVLYVLVCGKVPFDDQN 345
Query: 674 FSQMQAIFKIGTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
S + A K GT E PS++S + K L + D KR + +L PW+
Sbjct: 346 MSALHAKIKKGT---VEYPSYLSSDCKGLLSRMLVTDPLKRATLEEVLNHPWM 395
>YPL209c [D] KOG0580 Serine/threonine protein kinase
Length = 367
Score = 125 bits (314), Expect = 2e-28
Identities = 77/285 (27%), Positives = 135/285 (47%), Gaps = 36/285 (12%)
Query: 442 GARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAV 501
G ++G G FG VY + TG + A+K +E +
Sbjct: 107 GKKLGKGKFGKVYCVRHRSTGYICALKVMEKEEI-------------------------- 140
Query: 502 KNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNN 561
I + + E+ I L+H N+ YG + + + +EY+ G + +L
Sbjct: 141 -----IKYNLQKQFRREVEIQTSLNHPNLTKSYGYFHDEKRVYLLMEYLVNGEMYKLLRL 195
Query: 562 YGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPL 621
+GPF++ L ++ QI L Y+HK+NIIHRDIK NILI +K+TDFG S +
Sbjct: 196 HGPFNDILASDYIYQIANALDYMHKKNIIHRDIKPENILIGFNNVIKLTDFG----WSII 251
Query: 622 NKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAIF 681
N +N+R ++ G++ +++PE+V+ D W++G + E+ TG PF + +
Sbjct: 252 NPPENRRKTVCGTIDYLSPEMVESREYDHTIDAWALGVLAFELLTGAPPFEE-EMKDTTY 310
Query: 682 KIGTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
K + ++PS +S++A+ + K + D + R + PW+
Sbjct: 311 KRIAALDIKMPSNISQDAQDLILKLLKYDPKDRMRLGDVKMHPWI 355
>Hs19923464 [T] KOG0577 Serine/threonine protein kinase
Length = 898
Score = 125 bits (313), Expect = 3e-28
Identities = 88/287 (30%), Positives = 134/287 (46%), Gaps = 44/287 (15%)
Query: 445 IGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKNT 504
IG GSFG+VY NA T E++A+K++ +
Sbjct: 30 IGHGSFGAVYFATNAHTNEVVAIKKMSY------------------------------SG 59
Query: 505 SQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNYGP 564
Q H K D L+ E+ L++L H N + Y G + + +EY G + + + P
Sbjct: 60 KQTHEKWQDILK-EVKFLRQLKHPNTIEYKGCYLKEHTAWLVMEYCLGSASDLLEVHKKP 118
Query: 565 FDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPLNKQ 624
E + T L GLAYLH +IHRDIK NIL+ G VK+ DFG + SP N
Sbjct: 119 LQEVEIAAITHGALHGLAYLHSHALIHRDIKAGNILLTEPGQVKLADFGSASMASPAN-- 176
Query: 625 QNKRASLQGSVYWMAPEVVKQVVTTE---KADIWSVGCVIVEMFTGKHPFPDFSQMQAIF 681
S G+ YWMAPEV+ + + K DIWS+G +E+ K P + + M A++
Sbjct: 177 -----SFVGTPYWMAPEVILAMDEGQYDGKVDIWSLGITCIELAERKPPLFNMNAMSALY 231
Query: 682 KIGTNIIPEIPS--WVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
I N P + S W ++ + F+ + ++RP+S LL+ ++
Sbjct: 232 HIAQNDSPTLQSNEW-TDSFRRFVDYCLQKIPQERPTSAELLRHDFV 277
>CE07599 [T] KOG0576 Mitogen-activated protein kinase kinase kinase kinase
(MAP4K) germinal center kinase family
Length = 829
Score = 125 bits (313), Expect = 3e-28
Identities = 80/241 (33%), Positives = 117/241 (48%), Gaps = 40/241 (16%)
Query: 444 RIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKN 503
R+GSG++G VY + + L AVK V+L+ G N AV
Sbjct: 20 RVGSGTYGEVYKARDIRSDSLAAVKVVKLE---------------------AGDNFAV-- 56
Query: 504 TSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNYG 563
+Q E+ +++E H NI+ Y+GS L I +EY GGS+ + + G
Sbjct: 57 -----------IQQEIMVIRECSHPNIIAYFGSYIRRDRLWIVMEYCGGGSLQDIYHLTG 105
Query: 564 PFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPLNK 623
P E + R+ L GL YLH IHRDIKGANIL+ G VK+ DFG++ +++
Sbjct: 106 PLSELQIAFVCRETLRGLNYLHNMGKIHRDIKGANILLSSSGDVKLADFGVAAQIT---A 162
Query: 624 QQNKRASLQGSVYWMAPEVV---KQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAI 680
KR S G+ YWMAPEV K+ + D+W+ G +E+ + P D MQ +
Sbjct: 163 TIGKRKSFIGTPYWMAPEVACVEKRGGYGMQCDVWATGITAIELGECQPPLFDLHPMQVL 222
Query: 681 F 681
+
Sbjct: 223 Y 223
>CE27573 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 1420
Score = 124 bits (312), Expect = 4e-28
Identities = 90/307 (29%), Positives = 138/307 (44%), Gaps = 50/307 (16%)
Query: 434 EAPKSWLKGARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHS 493
+AP W I SGSFGSV+ M+ ++ ++A K
Sbjct: 1120 KAPFQWALLDHIASGSFGSVHRAMDIDSHRVIAAK------------------------- 1154
Query: 494 PGGGNTAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGG 553
+I R+ A++ E+NI ++L HEN+V YYG E ++ IF+EY G
Sbjct: 1155 ----------VMRIQRENHKAIESEINIFRQLIHENLVKYYGVQVEDSDVIIFMEYCSQG 1204
Query: 554 SVSSMLNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFG 613
++ + +G D +V+ +T +L + YLH IIHRDIK ANI +D +K+ DFG
Sbjct: 1205 TLERIC--HGKMDLKMVRQYTNSLLRAVQYLHSHKIIHRDIKPANIFLDKCTVLKLGDFG 1262
Query: 614 ISKKLSPLNKQQNKRASLQGSVYWMAPEVVKQVVTTE----------KADIWSVGCVIVE 663
S +L + + + G+ +MAPE+ E DIW++G +V
Sbjct: 1263 CSSRLVESSTVYGEFQTTAGTPQFMAPEIYSYGEKDETTGSYSGYGRSVDIWALGATVVN 1322
Query: 664 MFTGKHPFPDFSQMQAIFKI-GTNIIPEIPSWVSE--EAKAFLFKSFELDYRKRPSSLGL 720
M TGK PF ++ Q F + P P + + K F FE RP++ L
Sbjct: 1323 MMTGKVPFEGQTRHQIAFALCFRKQKPTYPDIADKRPDVKRFFDNCFEFLPNDRPTAAEL 1382
Query: 721 LQEPWLN 727
LQ + N
Sbjct: 1383 LQTTFAN 1389
>CE07737 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 1418
Score = 124 bits (312), Expect = 4e-28
Identities = 90/307 (29%), Positives = 138/307 (44%), Gaps = 50/307 (16%)
Query: 434 EAPKSWLKGARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHS 493
+AP W I SGSFGSV+ M+ ++ ++A K
Sbjct: 1120 KAPFQWALLDHIASGSFGSVHRAMDIDSHRVIAAK------------------------- 1154
Query: 494 PGGGNTAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGG 553
+I R+ A++ E+NI ++L HEN+V YYG E ++ IF+EY G
Sbjct: 1155 ----------VMRIQRENHKAIESEINIFRQLIHENLVKYYGVQVEDSDVIIFMEYCSQG 1204
Query: 554 SVSSMLNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFG 613
++ + +G D +V+ +T +L + YLH IIHRDIK ANI +D +K+ DFG
Sbjct: 1205 TLERIC--HGKMDLKMVRQYTNSLLRAVQYLHSHKIIHRDIKPANIFLDKCTVLKLGDFG 1262
Query: 614 ISKKLSPLNKQQNKRASLQGSVYWMAPEVVKQVVTTE----------KADIWSVGCVIVE 663
S +L + + + G+ +MAPE+ E DIW++G +V
Sbjct: 1263 CSSRLVESSTVYGEFQTTAGTPQFMAPEIYSYGEKDETTGSYSGYGRSVDIWALGATVVN 1322
Query: 664 MFTGKHPFPDFSQMQAIFKI-GTNIIPEIPSWVSE--EAKAFLFKSFELDYRKRPSSLGL 720
M TGK PF ++ Q F + P P + + K F FE RP++ L
Sbjct: 1323 MMTGKVPFEGQTRHQIAFALCFRKQKPTYPDIADKRPDVKRFFDNCFEFLPNDRPTAAEL 1382
Query: 721 LQEPWLN 727
LQ + N
Sbjct: 1383 LQTTFAN 1389
>At4g29810 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 363
Score = 124 bits (312), Expect = 4e-28
Identities = 91/292 (31%), Positives = 146/292 (49%), Gaps = 45/292 (15%)
Query: 445 IGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKNT 504
IG GS G V L + TG+ A+K ++L N
Sbjct: 76 IGKGSSGVVQLVQHKWTGQFFALKVIQL------------------------------NI 105
Query: 505 SQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNYGP 564
+ RK A+ E+ I + N+VT Y S + G +++ LEY+ GGS++ L +
Sbjct: 106 DEAIRK---AIAQELKINQSSQCPNLVTSYQSFYDNGAISLILEYMDGGSLADFLKSVKA 162
Query: 565 FDEPLVKNFTRQILIGLAYL-HKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPLNK 623
+ + RQ+L GL YL H R+IIHRD+K +N+LI+ +G VKITDFG+S ++
Sbjct: 163 IPDSYLSAIFRQVLQGLIYLHHDRHIIHRDLKPSNLLINHRGEVKITDFGVSTVMTNTAG 222
Query: 624 QQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQ---AI 680
N + G+ +M+PE + K+DIWS+G V++E TGK P+ +Q + ++
Sbjct: 223 LAN---TFVGTYNYMSPERIVGNKYGNKSDIWSLGLVVLECATGKFPYAPPNQEETWTSV 279
Query: 681 FKIGTNII----PEIPSW-VSEEAKAFLFKSFELDYRKRPSSLGLLQEPWLN 727
F++ I+ P +PS S E +F+ + D R S+ L++ P+LN
Sbjct: 280 FELMEAIVDQPPPALPSGNFSPELSSFISTCLQKDPNSRSSAKELMEHPFLN 331
>YBR028c [RT] KOG0598 Ribosomal protein S6 kinase and related proteins
Length = 525
Score = 124 bits (310), Expect = 7e-28
Identities = 79/278 (28%), Positives = 140/278 (49%), Gaps = 13/278 (4%)
Query: 445 IGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKNT 504
+G G++G V L + T +L A+KQ+ ++ + D ++ GN +
Sbjct: 134 LGQGAYGKVLLVKDVNTSKLYAMKQLRKAEILISQ---TATDSKREDEDKNDGNN--NDN 188
Query: 505 SQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNYGP 564
K ++ E +IL E+ H NIV + S + L + L+Y+PGG + L +G
Sbjct: 189 DDGLSKRLERTFAERSILSEIEHPNIVKLFYSFHDNSKLYLLLQYIPGGELFYHLKEHGT 248
Query: 565 FDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKL---SPL 621
DE V + +I L +LH + +++RD+K N L++ +G + +TDFG+SKK S +
Sbjct: 249 LDETTVSFYAAEISCALRFLHTKGVVYRDLKPENCLLNQRGHLVLTDFGLSKKSANDSAV 308
Query: 622 NKQQ----NKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQM 677
+++ N S+ G+ + APE++ ++ D +S+GC++ +M GK P+ +
Sbjct: 309 DEEDPENVNALYSIIGTPEYCAPEILLGKAYSQNCDWYSLGCLLYDMLVGKPPYTGSNHK 368
Query: 678 QAIFKIGTNII-PEIPSWVSEEAKAFLFKSFELDYRKR 714
I KI N P+IP ++SE K L + + KR
Sbjct: 369 VIINKIQQNKQGPKIPFYLSEGMKDILNALLKKETAKR 406
>At1g49180_1 [OUT] KOG0595 Serine/threonine-protein kinase involved in autophagy
Length = 225
Score = 123 bits (309), Expect = 9e-28
Identities = 69/182 (37%), Positives = 106/182 (57%), Gaps = 7/182 (3%)
Query: 505 SQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNYGP 564
S+++R + D L +E+ L + H NI+ SQ+ L + LEY GG++SS + YG
Sbjct: 39 SKLNRNLRDCLNNELEFLSSVDHPNIIRLLHVSQDDDFLVMVLEYCDGGTLSSYIQRYGR 98
Query: 565 FDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGG---VKITDFGISKKLSPL 621
+E + K F +QI GL +H +IIHRD+K NILID G +KI DF +++KL P
Sbjct: 99 VEEDIAKRFMKQIGAGLEIIHDNHIIHRDLKPENILIDGSGDDLVLKIADFSLARKLHPG 158
Query: 622 NKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAIF 681
+ ++ GS ++MAPEV++ EKAD+WSVG ++ E+ G PF + +Q +
Sbjct: 159 KYLE----TVCGSPFYMAPEVLQFQRYNEKADMWSVGAILFELLHGYPPFRGNNNVQVLR 214
Query: 682 KI 683
I
Sbjct: 215 NI 216
>HsM5454184 [T] KOG4721 Serine/threonine protein kinase contains leucine zipper
domain
Length = 859
Score = 123 bits (308), Expect = 1e-27
Identities = 72/209 (34%), Positives = 114/209 (54%), Gaps = 5/209 (2%)
Query: 509 RKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNYGPFDEP 568
+K+ D + ++ L++L H NI+T+ G + I +E+ G + +L P
Sbjct: 152 KKVRDLKETDIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPS 211
Query: 569 LVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPLNKQQNKR 628
L+ +++ I G+ YLH IIHRD+K N+LI VKI+DFG SK+LS ++ +
Sbjct: 212 LLVDWSMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELS----DKSTK 267
Query: 629 ASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAIFKIGTNII 688
S G+V WMAPEV++ +EK DIWS G V+ E+ TG+ P+ D I+ +G+N +
Sbjct: 268 MSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSL 327
Query: 689 P-EIPSWVSEEAKAFLFKSFELDYRKRPS 716
+PS + K L + + R RPS
Sbjct: 328 HLPVPSSCPDGFKILLRQCWNSKPRNRPS 356
>HsM4507279 [D] KOG0580 Serine/threonine protein kinase
Length = 402
Score = 123 bits (308), Expect = 1e-27
Identities = 81/285 (28%), Positives = 134/285 (46%), Gaps = 37/285 (12%)
Query: 442 GARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAV 501
G +G G FG+VYL ++ ++A+K V K AGV
Sbjct: 135 GRPLGKGKFGNVYLAREKQSKFILALK-VLFKAQLEKAGVEH------------------ 175
Query: 502 KNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNN 561
L+ E+ I L H NI+ YG + + + LEY P G+V L
Sbjct: 176 ------------QLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQK 223
Query: 562 YGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPL 621
FDE N +I L+Y H + +IHRDIK N+L+ G +KI DFG S +
Sbjct: 224 LSKFDEQRTANLYNRIANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWS-----V 278
Query: 622 NKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAIF 681
+ ++R +L G++ ++ PE+++ + EK D+WS+G + E GK PF + + Q +
Sbjct: 279 HAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPF-EANTYQETY 337
Query: 682 KIGTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
K + + P +V+E A+ + + + + +RP +L+ PW+
Sbjct: 338 KRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWI 382
>Hs21735552 [T] KOG4721 Serine/threonine protein kinase contains leucine zipper
domain
Length = 859
Score = 123 bits (308), Expect = 1e-27
Identities = 72/209 (34%), Positives = 114/209 (54%), Gaps = 5/209 (2%)
Query: 509 RKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNYGPFDEP 568
+K+ D + ++ L++L H NI+T+ G + I +E+ G + +L P
Sbjct: 152 KKVRDLKETDIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPS 211
Query: 569 LVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPLNKQQNKR 628
L+ +++ I G+ YLH IIHRD+K N+LI VKI+DFG SK+LS ++ +
Sbjct: 212 LLVDWSMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELS----DKSTK 267
Query: 629 ASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAIFKIGTNII 688
S G+V WMAPEV++ +EK DIWS G V+ E+ TG+ P+ D I+ +G+N +
Sbjct: 268 MSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSL 327
Query: 689 P-EIPSWVSEEAKAFLFKSFELDYRKRPS 716
+PS + K L + + R RPS
Sbjct: 328 HLPVPSSCPDGFKILLRQCWNSKPRNRPS 356
>YFR014c [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 446
Score = 122 bits (307), Expect = 1e-27
Identities = 88/305 (28%), Positives = 139/305 (44%), Gaps = 41/305 (13%)
Query: 430 PTKVEAPKSWLKGARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESK 489
P K ++ G +G+G+FG V N ETGE +AVK +
Sbjct: 28 PASYVNKKKYVFGKTLGAGTFGVVRQAKNTETGEDVAVKIL------------------- 68
Query: 490 KAHSPGGGNTAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEY 549
+K + ++ ++AL E++IL+ LHH NIV + + I +
Sbjct: 69 -----------IKKALKGNKVQLEALYDELDILQRLHHPNIVAFKDWFESKDKFYIITQL 117
Query: 550 VPGGSVSSMLNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGG--- 606
GG + + G F E +IL + Y+H +NI+HRD+K N+L K
Sbjct: 118 AKGGELFDRILKKGKFTEEDAVRILVEILSAVKYMHSQNIVHRDLKPENLLYIDKSDESP 177
Query: 607 VKITDFGISKKLSPLNKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFT 666
+ + DFGI+K+L + K A GS+ ++APEV+ Q + DIWS+G + +
Sbjct: 178 LVVADFGIAKRLKSDEELLYKPA---GSLGYVAPEVLTQDGHGKPCDIWSIGVITYTLLC 234
Query: 667 GKHPFPDFSQMQAIFKIGTNIIP---EIPSW--VSEEAKAFLFKSFELDYRKRPSSLGLL 721
G F + + T P P W VS +AK F+ K+ LD KRP++ LL
Sbjct: 235 GYSAFRAERVQDFLDECTTGEYPVKFHRPYWDSVSNKAKQFILKALNLDPSKRPTAAELL 294
Query: 722 QEPWL 726
++PW+
Sbjct: 295 EDPWI 299
>YDR523c [T] KOG0201 Serine/threonine protein kinase
Length = 490
Score = 122 bits (307), Expect = 1e-27
Identities = 93/307 (30%), Positives = 141/307 (45%), Gaps = 41/307 (13%)
Query: 427 ISLPTKVEAPKSWLKGARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIAD 486
IS+ ++ K + + IG G+FG VY ++ T E++A+K V L+ + D
Sbjct: 6 ISIRSRTPPSKLYSIQSCIGRGNFGDVYKAVDRVTQEIVAIKVVNLEHS----------D 55
Query: 487 ESKKAHSPGGGNTAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIF 546
E I+ L E+ L EL I Y + E ++ I
Sbjct: 56 ED-----------------------IELLAQEIFFLAELKSPLITNYIATMLEDVSMWIV 92
Query: 547 LEYVPGGSVSSMLNN--YGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIK 604
+EY GGS S +L E V ++ +GL YLH++ IHRDIK ANIL++ +
Sbjct: 93 MEYCGGGSCSDLLKRSYVNGLPEEKVSFIIHEVTLGLKYLHEQRKIHRDIKAANILLNEE 152
Query: 605 GGVKITDFGISKKLSPLNKQQNKRASLQGSVYWMAPEVVKQVVT--TEKADIWSVGCVIV 662
G VK+ DFG+S + + KR + G+ YWMAPEVV V EKADIWS+G
Sbjct: 153 GMVKLGDFGVSGHI----RSTLKRDTFVGTPYWMAPEVVCCEVDGYNEKADIWSLGITTY 208
Query: 663 EMFTGKHPFPDFSQMQAIFKIGTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQ 722
E+ G P + M+ + + P++ S+ AK F+ RPS+ LL
Sbjct: 209 ELLKGLPPLSKYDPMKVMTNLPKRKPPKLQGPFSDAAKDFVAGCLVKTPADRPSAYNLLS 268
Query: 723 EPWLNTV 729
++ +
Sbjct: 269 FEFVKNI 275
>Hs20547806 [R] KOG0589 Serine/threonine protein kinase
Length = 489
Score = 122 bits (307), Expect = 1e-27
Identities = 78/279 (27%), Positives = 133/279 (46%), Gaps = 38/279 (13%)
Query: 445 IGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKNT 504
IG GSFG L + + ++ A+K++ L + NT
Sbjct: 10 IGEGSFGRALLVQHESSNQMFAMKEIRLPKS-------------------------FSNT 44
Query: 505 SQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNYGP 564
++ + +L ++ H NIV + S + G+L I +EY GG + +
Sbjct: 45 QNSRKEAV--------LLAKMKHPNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKG 96
Query: 565 --FDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPLN 622
F E ++ N+ Q+ +G+ ++HK+ ++HRDIK NI + G VK+ DFG ++ LS
Sbjct: 97 KLFPEDMILNWFTQMCLGVNHIHKKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLS--- 153
Query: 623 KQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAIFK 682
+ G+ Y++ PE+ + + K+DIWS+GC++ E+ T KHPF S I K
Sbjct: 154 NPMAFACTYVGTPYYVPPEIWENLPYNNKSDIWSLGCILYELCTLKHPFQANSWKNLILK 213
Query: 683 IGTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLL 721
+ I +PS S E + + + F+ + RPS+ LL
Sbjct: 214 VCQGCISPLPSHYSYELQFLVKQMFKRNPSHRPSATTLL 252
>7293761 [T] KOG4721 Serine/threonine protein kinase contains leucine zipper
domain
Length = 977
Score = 122 bits (307), Expect = 1e-27
Identities = 71/217 (32%), Positives = 118/217 (53%), Gaps = 5/217 (2%)
Query: 501 VKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLN 560
+KN + +K+ + + ++ L++L HENI+ + G + I +E+ P G + ++L
Sbjct: 180 LKNETVAVKKVKELKETDIKHLRKLDHENIIKFKGVCTQSPVFCIIMEFCPYGPLQNILK 239
Query: 561 NYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSP 620
+ ++++QI +G+ YLH IIHRD+K NILI VKI+DFG S++ +
Sbjct: 240 EEQVMLPSRLVSWSKQIALGMQYLHSHKIIHRDLKSPNILISTNEVVKISDFGTSREWNE 299
Query: 621 LNKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAI 680
+ + + S G+V WMAPEV++ +EK DIWS G V+ EM T + P+ D I
Sbjct: 300 I----STKMSFAGTVAWMAPEVIRNEPCSEKVDIWSYGVVLWEMLTCEIPYKDVDSSAII 355
Query: 681 FKIGTNIIP-EIPSWVSEEAKAFLFKSFELDYRKRPS 716
+ +G N + +PS E K + ++ R RPS
Sbjct: 356 WGVGNNSLKLLVPSTCPEGFKLLVKLCWKSKPRNRPS 392
>YOL100w [T] KOG0592 3-phosphoinositide-dependent protein kinase (PDK1)
Length = 1081
Score = 122 bits (306), Expect = 2e-27
Identities = 66/214 (30%), Positives = 111/214 (51%), Gaps = 12/214 (5%)
Query: 507 IHRKMIDALQHEMNILKELHHE-NIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNYGPF 565
I +K + + E L++L++ ++V + + Q+ +L LEY P G S++ YG
Sbjct: 216 IRQKKVKYVSIEKTALQKLNNSPSVVRLFSTFQDESSLYFLLEYAPNGDFLSLMKKYGSL 275
Query: 566 DEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPLNKQQ 625
DE + + QI+ + YLH IIHRDIK NIL+D + +K+TDFG +K L+P N
Sbjct: 276 DETCARYYAAQIIDAIDYLHSNGIIHRDIKPENILLDGEMKIKLTDFGTAKLLNPTNNSV 335
Query: 626 NK--------RASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFP---DF 674
+K S G+ +++PE++ T + DIW+ GC++ +M GK PF ++
Sbjct: 336 SKPEYDLSTRSKSFVGTAEYVSPELLNDSFTDYRCDIWAFGCILFQMIAGKPPFKATNEY 395
Query: 675 SQMQAIFKIGTNIIPEIPSWVSEEAKAFLFKSFE 708
Q + K+ P P + + K L K+ +
Sbjct: 396 LTFQKVMKVQYAFTPGFPLIIRDLVKKILVKNLD 429
>At5g14720 [T] KOG0582 Ste20-like serine/threonine protein kinase
Length = 561
Score = 122 bits (306), Expect = 2e-27
Identities = 71/221 (32%), Positives = 115/221 (51%), Gaps = 7/221 (3%)
Query: 512 IDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNYGP--FDEPL 569
+D ++ E+ + ++H N++ + S G L + + Y+ GGS ++ + P F+EP+
Sbjct: 56 LDGIRREVQTMSLINHPNVLQAHCSFTTGHQLWVVMPYMAGGSCLHIIKSSYPDGFEEPV 115
Query: 570 VKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPLNKQQNKRA 629
+ R+ L L YLH IHRD+K NIL+D G VK+ DFG+S + +Q R
Sbjct: 116 IATLLRETLKALVYLHAHGHIHRDVKAGNILLDSNGAVKLADFGVSACMFDTGDRQRSRN 175
Query: 630 SLQGSVYWMAPEVVKQVVTTE-KADIWSVGCVIVEMFTGKHPFPDFSQMQAIFKIGTNII 688
+ G+ WMAPEV++Q+ + KAD+WS G +E+ G PF + M+ + N
Sbjct: 176 TFVGTPCWMAPEVMQQLHGYDFKADVWSFGITALELAHGHAPFSKYPPMKVLLMTLQNAP 235
Query: 689 P----EIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPW 725
P E S+ K + D +KRP+S LL+ P+
Sbjct: 236 PGLDYERDKRFSKAFKEMVGTCLVKDPKKRPTSEKLLKHPF 276
>At1g51660 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 366
Score = 122 bits (306), Expect = 2e-27
Identities = 91/295 (30%), Positives = 145/295 (48%), Gaps = 48/295 (16%)
Query: 440 LKGARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNT 499
++G RIGSG+ G+VY ++ + L A+K + GN
Sbjct: 80 VRGNRIGSGAGGTVYKVIHRPSSRLYALKVIY-------------------------GNH 114
Query: 500 AVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSML 559
QI R E+ IL++++H N+V + + G + + LE++ GS L
Sbjct: 115 EETVRRQICR--------EIEILRDVNHPNVVKCHEMFDQNGEIQVLLEFMDKGS----L 162
Query: 560 NNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLS 619
+ E + + +RQIL GLAYLH R+I+HRDIK +N+LI+ VKI DFG+S+ L+
Sbjct: 163 EGAHVWKEQQLADLSRQILSGLAYLHSRHIVHRDIKPSNLLINSAKNVKIADFGVSRILA 222
Query: 620 PLNKQQNKRASLQGSVYWMAPEVVKQVVTTEK-----ADIWSVGCVIVEMFTGKHPFPDF 674
N S G++ +M+PE + + K DIWS+G I+E + G+ PFP
Sbjct: 223 QTMDPCN---SSVGTIAYMSPERINTDLNQGKYDGYAGDIWSLGVSILEFYLGRFPFPVS 279
Query: 675 SQ---MQAIFKIGTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
Q + I + PE P+ S E + F+ + + KR S++ LLQ P++
Sbjct: 280 RQGDWASLMCAICMSQPPEAPATASPEFRHFISCCLQREPGKRRSAMQLLQHPFI 334
>Hs4507275 [D] KOG0580 Serine/threonine protein kinase
Length = 403
Score = 121 bits (304), Expect = 3e-27
Identities = 79/285 (27%), Positives = 134/285 (46%), Gaps = 37/285 (12%)
Query: 442 GARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAV 501
G +G G FG+VYL ++ ++A+K V K AGV
Sbjct: 136 GRPLGKGKFGNVYLAREKQSKFILALK-VLFKAQLEKAGVEH------------------ 176
Query: 502 KNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNN 561
L+ E+ I L H NI+ YG + + + LEY P G+V L
Sbjct: 177 ------------QLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQK 224
Query: 562 YGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPL 621
FDE + ++ L+Y H + +IHRDIK N+L+ G +KI DFG S +
Sbjct: 225 LSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWS-----V 279
Query: 622 NKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAIF 681
+ ++R +L G++ ++ PE+++ + EK D+WS+G + E GK PF + + Q +
Sbjct: 280 HAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPF-EANTYQETY 338
Query: 682 KIGTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
K + + P +V+E A+ + + + + +RP +L+ PW+
Sbjct: 339 KRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWI 383
>YPL203w [T] KOG0616 cAMP-dependent protein kinase catalytic subunit (PKA)
Length = 380
Score = 121 bits (303), Expect = 4e-27
Identities = 79/291 (27%), Positives = 133/291 (45%), Gaps = 43/291 (14%)
Query: 445 IGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKNT 504
+G+GSFG V+L + G A+K +K
Sbjct: 76 LGTGSFGRVHLVRSVHNGRYYAIK-------------------------------VLKKQ 104
Query: 505 SQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNYGP 564
+ K ++ E +LK + H ++ +G+ Q+ N+ + ++Y+ GG + S+L
Sbjct: 105 QVVKMKQVEHTNDERRMLKLVEHPFLIRMWGTFQDARNIFMVMDYIEGGELFSLLRKSQR 164
Query: 565 FDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPLNKQ 624
F P+ K + ++++ L YLH NII+RD+K NIL+D G +KITDFG +K++
Sbjct: 165 FPNPVAKFYAAEVILALEYLHAHNIIYRDLKPENILLDRNGHIKITDFGFAKEV------ 218
Query: 625 QNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAIFKIG 684
Q +L G+ ++APEV+ + D WS+G +I EM G PF D + M+ KI
Sbjct: 219 QTVTWTLCGTPDYIAPEVITTKPYNKSVDWWSLGVLIYEMLAGYTPFYDTTPMKTYEKIL 278
Query: 685 TNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSL-----GLLQEPWLNTVL 730
+ P + + L K D +R +L + PW + V+
Sbjct: 279 QGKV-VYPPYFHPDVVDLLSKLITADLTRRIGNLQSGSRDIKAHPWFSEVV 328
>YKL101w [D] KOG0588 Serine/threonine protein kinase
Length = 1518
Score = 121 bits (303), Expect = 4e-27
Identities = 96/313 (30%), Positives = 153/313 (48%), Gaps = 23/313 (7%)
Query: 427 ISLPTKVEAPKS------WLKGARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTA- 479
+S+ TK KS W G +G GS G V L N ETG+L A+K V K V
Sbjct: 63 VSVATKSSKRKSRDTVGPWKLGKTLGKGSSGRVRLAKNMETGQLAAIKIVPKKKAFVHCS 122
Query: 480 --GVV----SIADESKKAHSPGGGNTAVKNTSQIHRKMIDALQHEMNILKELHHENIVTY 533
G V S + + SP + N SQ + ++ E+ I+K + H N++
Sbjct: 123 NNGTVPNSYSSSMVTSNVSSPSIASREHSNHSQTNPY---GIEREIVIMKLISHTNVMAL 179
Query: 534 YGSSQEGGNLNIFLEYVPGGSVSSMLNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRD 593
+ + L + LEYV GG + L + G E ++ +QI+ G++Y H NI HRD
Sbjct: 180 FEVWENKSELYLVLEYVDGGELFDYLVSKGKLPEREAIHYFKQIVEGVSYCHSFNICHRD 239
Query: 594 IKGANILIDIKG-GVKITDFGISKKLSPLNKQQNKRASLQGSVYWMAPEVVK-QVVTTEK 651
+K N+L+D K +KI DFG++ P NK GS ++ +PE+V +
Sbjct: 240 LKPENLLLDKKNRRIKIADFGMAALELP-NKLLKTSC---GSPHYASPEIVMGRPYHGGP 295
Query: 652 ADIWSVGCVIVEMFTGKHPFPDFSQMQAIFKIGTNIIPEIPSWVSEEAKAFLFKSFELDY 711
+D+WS G V+ + TG PF D + + + K+ + ++PS +S EA+ + K +D
Sbjct: 296 SDVWSCGIVLFALLTGHLPFNDDNIKKLLLKVQSGKY-QMPSNLSSEARDLISKILVIDP 354
Query: 712 RKRPSSLGLLQEP 724
KR ++ +L+ P
Sbjct: 355 EKRITTQEILKHP 367
>Hs6005810 [T] KOG0576 Mitogen-activated protein kinase kinase kinase kinase
(MAP4K) germinal center kinase family
Length = 833
Score = 121 bits (303), Expect = 4e-27
Identities = 92/297 (30%), Positives = 139/297 (45%), Gaps = 51/297 (17%)
Query: 444 RIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKN 503
R+G G++G V+ + +G+L+A+K V+++P D+
Sbjct: 22 RLGGGTYGEVFKARDKVSGDLVALKMVKMEP-----------DDD--------------- 55
Query: 504 TSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNYG 563
+ LQ E+ ILK H NIV Y+GS L I +E+ GS+ + G
Sbjct: 56 --------VSTLQKEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTG 107
Query: 564 PFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPLNK 623
E + R++L GLAYLH + IHRDIKGANILI+ G V++ DFGIS + +
Sbjct: 108 SLSELQISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGIS---AQIGA 164
Query: 624 QQNKRASLQGSVYWMAPEVVKQVVT---TEKADIWSVGCVIVEMFTGKHPFPDFSQMQAI 680
+R S G+ YWMAPEV + E DIWS+G +E+ + P D ++ +
Sbjct: 165 TLARRLSFIGTPYWMAPEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVL 224
Query: 681 FKIGTN-----IIPEIPSWVSEEAKAFLFKSFELDYRKRPS-----SLGLLQEPWLN 727
F + + + E W S F+ + +KRPS S L+ +P LN
Sbjct: 225 FLMTKSGYQPPRLKEKGKW-SAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLN 280
>At5g67080 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 344
Score = 121 bits (303), Expect = 4e-27
Identities = 92/299 (30%), Positives = 144/299 (47%), Gaps = 43/299 (14%)
Query: 439 WLKGARIGSGSFGSVYLGM--NAETGE---LMAVKQVELKPTAVTAGVVSIADESKKAHS 493
W++G IG G+F +V L N ++GE LMAVK + + G S+A+E
Sbjct: 3 WIRGETIGYGTFSTVSLATRSNNDSGEFPPLMAVKSAD------SYGAASLANE------ 50
Query: 494 PGGGNTAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGG 553
+ ++D L + N + E+ G N+FLEY G
Sbjct: 51 ---------------KSVLDNLGDDCNEIVRCFGEDRTVENGEEMH----NLFLEYASRG 91
Query: 554 SVSSMLNNYGP--FDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITD 611
S+ S L E V+ T +L GL ++H H D+K NIL+ G VKI D
Sbjct: 92 SLESYLKKLAGEGVPESTVRRHTGSVLRGLRHIHANGFAHCDLKLGNILLFGDGAVKIAD 151
Query: 612 FGISKKLSPLNKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPF 671
FG++K++ L N ++G+ +MAPE V + D+W++GCV+VEMF+GK +
Sbjct: 152 FGLAKRIGDLT-ALNYGVQIRGTPLYMAPESVNDNEYGSEGDVWALGCVVVEMFSGKTAW 210
Query: 672 ---PDFSQMQAIFKIGT-NIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
+ M + +IG + +P IP +SE+ + FL K F D +KR ++ LL P++
Sbjct: 211 SLKEGSNFMSLLLRIGVGDEVPMIPEELSEQGRDFLSKCFVKDPKKRWTAEMLLNHPFV 269
>7302458 [T] KOG0574 STE20-like serine/threonine kinase MST
Length = 596
Score = 121 bits (303), Expect = 4e-27
Identities = 86/286 (30%), Positives = 139/286 (48%), Gaps = 42/286 (14%)
Query: 444 RIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKN 503
++G GS+GSVY ++ E+ ++A+K V ++
Sbjct: 47 KLGEGSYGSVYKAVHKESSSIVAIKLVPVE------------------------------ 76
Query: 504 TSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLN-NY 562
S +H + E++I+++ +V YYGS + +L I +EY GSVS ++
Sbjct: 77 -SDLHE-----IIKEISIMQQCDSPYVVRYYGSYFKQYDLWICMEYCGAGSVSDIMRLRK 130
Query: 563 GPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPLN 622
E + L GL YLH R IHRDIK ANIL++ +G K+ DFG++ +L+
Sbjct: 131 KTLTEDEIATILSDTLQGLVYLHLRRKIHRDIKAANILLNTEGYAKLADFGVAGQLTDT- 189
Query: 623 KQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAIFK 682
KR ++ G+ +WMAPEV++++ ADIWS+G +EM GK P+ + M+AIF
Sbjct: 190 --MAKRNTVIGTPFWMAPEVIEEIGYDCVADIWSLGITALEMAEGKPPYGEIHPMRAIFM 247
Query: 683 IGTNIIPEI--PSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
I P P S E F+ K + R ++ LL+ ++
Sbjct: 248 IPQKPPPSFREPDRWSTEFIDFVSKCLVKEPDDRATATELLEHEFI 293
>CE23001 [R] KOG0589 Serine/threonine protein kinase
Length = 579
Score = 120 bits (302), Expect = 6e-27
Identities = 80/289 (27%), Positives = 138/289 (47%), Gaps = 34/289 (11%)
Query: 430 PTKVEAPKSWLKGARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESK 489
P A + + +G G+FGS L E L+ +K++ + D S+
Sbjct: 162 PRATSAQNRYERIRTVGKGAFGSAVLYRRREDSSLVIIKEINMYDL----------DSSQ 211
Query: 490 KAHSPGGGNTAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEY 549
+ + +E+++L + H NI+ YY S +E G L I +EY
Sbjct: 212 RRLA----------------------LNEVSLLSRIEHPNIIAYYDSFEEEGVLMIEMEY 249
Query: 550 VPGGSVSSMLNN-YGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVK 608
GG+++ ML+ DE + + Q+ +AYLH+ +++HRD+K AN+ + VK
Sbjct: 250 ADGGTLAQMLSRTQNLLDEEQIGDMMIQMCSAVAYLHENSVLHRDLKTANVFLTRDSFVK 309
Query: 609 ITDFGISKKLSPLNKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGK 668
I DFGISK + Q + ++ G+ Y+++PE+ V EK+D+W++GC++ EM K
Sbjct: 310 IGDFGISKIMGTETLAQGAK-TVVGTPYYISPEMCSGVSYNEKSDMWALGCILYEMCCLK 368
Query: 669 HPFPDFSQMQAIFKIGTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSS 717
F + + I T + S E K + + +LD +KRPS+
Sbjct: 369 KAFEGDNLPALVNSIMTCAYTPVKGPYSAEMKMVIRELLQLDPQKRPSA 417
>At2g37840 [OUT] KOG0595 Serine/threonine-protein kinase involved in autophagy
Length = 257
Score = 120 bits (302), Expect = 6e-27
Identities = 73/248 (29%), Positives = 124/248 (49%), Gaps = 39/248 (15%)
Query: 439 WLKGARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGN 498
+L G +IGSGSF V+ + G +A+K++ +
Sbjct: 12 YLVGRQIGSGSFSVVWEARHRVDGTEVAIKEIAM-------------------------- 45
Query: 499 TAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSM 558
++++K+ ++L E+ IL+ ++H NI+ + G +++ LEY GG +S
Sbjct: 46 ------DRLNKKLQESLMSEIFILRRINHPNIIRLIDMIKSPGKVHLVLEYCKGGDLSVY 99
Query: 559 LNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIK---GGVKITDFGIS 615
+ +G E K+F +Q+ GL L NIIHRD+K N+L+ +KI DFG +
Sbjct: 100 VQRHGIVPEATAKHFMQQLAAGLQVLRDNNIIHRDLKPQNLLLSTNENDADLKIADFGFA 159
Query: 616 KKLSPLNKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFS 675
+ L P + +L GS +MAPE+++ KAD+WSVG ++ ++ TG+ PF S
Sbjct: 160 RSLQP----RGLAETLCGSPLYMAPEIMQLQKYDAKADLWSVGAILFQLVTGRTPFTGNS 215
Query: 676 QMQAIFKI 683
Q+Q + I
Sbjct: 216 QIQLLQNI 223
>Hs4758696 [T] KOG4721 Serine/threonine protein kinase contains leucine zipper
domain
Length = 966
Score = 120 bits (301), Expect = 7e-27
Identities = 68/209 (32%), Positives = 114/209 (54%), Gaps = 5/209 (2%)
Query: 509 RKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNYGPFDEP 568
+K+ + + ++ L++L H NI+ + G + I +EY G + +L
Sbjct: 195 KKVREQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPR 254
Query: 569 LVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPLNKQQNKR 628
L+ +++ I G+ YLH IIHRD+K N+L+ VKI+DFG SK+LS ++ +
Sbjct: 255 LLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELS----DKSTK 310
Query: 629 ASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAIFKIGTNII 688
S G+V WMAPEV++ +EK DIWS G V+ E+ TG+ P+ D I+ +G+N +
Sbjct: 311 MSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSL 370
Query: 689 P-EIPSWVSEEAKAFLFKSFELDYRKRPS 716
+PS + K + ++++ R RPS
Sbjct: 371 HLPVPSTCPDGFKILMKQTWQSKPRNRPS 399
>CE23702 [T] KOG4721 Serine/threonine protein kinase contains leucine zipper
domain
Length = 855
Score = 120 bits (300), Expect = 1e-26
Identities = 63/188 (33%), Positives = 103/188 (54%), Gaps = 3/188 (1%)
Query: 501 VKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLN 560
++N + +K+ + E+ L+ L H+NI+ + G + I +EY G + ++L
Sbjct: 81 LENRTVAVKKVNQLKETEIKHLRHLRHQNIIEFLGVCSKSPCYCIVMEYCSKGQLCTVLK 140
Query: 561 NYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSP 620
+ L + ++I G+ YLH+ +IHRD+K NILI + +KI DFG S
Sbjct: 141 SRNTITRELFAQWVKEIADGMHYLHQNKVIHRDLKSPNILISAEDSIKICDFGTSHM--- 197
Query: 621 LNKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAI 680
K + S G+V WMAPE++K+ EK D++S G V+ EM T + P+ + +QM I
Sbjct: 198 QKKMDSTMMSFCGTVSWMAPEMIKKQPCNEKVDVYSFGVVLWEMLTRETPYANIAQMAII 257
Query: 681 FKIGTNII 688
F +GTNI+
Sbjct: 258 FGVGTNIL 265
>YDR507c [D] KOG0588 Serine/threonine protein kinase
Length = 1142
Score = 119 bits (297), Expect = 2e-26
Identities = 91/297 (30%), Positives = 141/297 (46%), Gaps = 35/297 (11%)
Query: 439 WLKGARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGN 498
W G +G GS G V L N TG+ AVK + SK + G
Sbjct: 19 WKLGETLGLGSTGKVQLARNGSTGQEAAVKVI-----------------SKAVFNTGN-- 59
Query: 499 TAVKNTSQIHRKMIDAL----QHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGS 554
V TS + DAL + E+ I+K L+H N++ Y + +L + LEY G
Sbjct: 60 --VSGTSIVGSTTPDALPYGIEREIIIMKLLNHPNVLRLYDVWETNTDLYLVLEYAEKGE 117
Query: 555 VSSMLNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGI 614
+ ++L GP E F RQI+IG++Y H I+HRD+K N+L+D K +KI DFG
Sbjct: 118 LFNLLVERGPLPEHEAIRFFRQIIIGVSYCHALGIVHRDLKPENLLLDHKYNIKIADFG- 176
Query: 615 SKKLSPLNKQQNKRASLQGSVYWMAPEVVKQVVTTEKA-DIWSVGCVIVEMFTGKHPF-- 671
++ L + + GS ++ APE+V + A D+WS G ++ + TG+ PF
Sbjct: 177 ---MAALETEGKLLETSCGSPHYAAPEIVSGIPYQGFASDVWSCGVILFALLTGRLPFDE 233
Query: 672 PDFSQMQAIFKIGTNIIPEIPS--WVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
D + + K+ E+PS +S EA+ + K +D +R + +L+ P L
Sbjct: 234 EDGNIRTLLLKVQKGEF-EMPSDDEISREAQDLIRKILTVDPERRIKTRDILKHPLL 289
>SPBC32C12.03c [T] KOG0583 Serine/threonine protein kinase
Length = 423
Score = 118 bits (296), Expect = 3e-26
Identities = 92/292 (31%), Positives = 135/292 (45%), Gaps = 41/292 (14%)
Query: 438 SWLKGARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGG 497
+W+ IG+GS G V L +N TGE A+K + P
Sbjct: 52 NWIIKKTIGAGSMGKVKLVVNILTGEKAALKMIPFTPN---------------------- 89
Query: 498 NTAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSS 557
NTSQ R +Q E + + L H NI + I EYVPGG +
Sbjct: 90 -----NTSQTVR-----VQREALLGRLLRHPNICRVIDCIRTPACTYILFEYVPGGQLLE 139
Query: 558 MLNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILI-DIKGGVKITDFGISK 616
+ G DE L ++F Q++ L YLHK I+HRD+K N+L+ VK+ DFG+S
Sbjct: 140 YILARGKLDEDLARSFAMQLINALVYLHKNFIVHRDLKIENVLLTQDSRQVKLIDFGLSN 199
Query: 617 KLSPLNKQQNKRASLQGSVYWMAPEVV--KQVVTTEKADIWSVGCVIVEMFTGKHPFPDF 674
S + + + GS+Y+ APE++ K + E D+WS+G VI M G+ PF D
Sbjct: 200 FYS----KDDLLRTYCGSLYFAAPELLDAKPYIGPE-VDVWSLGVVIYVMVCGRVPFDDV 254
Query: 675 SQMQAIFKIGTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
S KI + + E PS++SE+ + + ++ RKR S + PWL
Sbjct: 255 SVPMLHSKIKSGKL-EFPSYISEDCCSLIAAMLNVNPRKRCSLEQAAKFPWL 305
>CE21615 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 378
Score = 118 bits (296), Expect = 3e-26
Identities = 81/286 (28%), Positives = 145/286 (50%), Gaps = 42/286 (14%)
Query: 444 RIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKN 503
+IG G+ G+V++ A + +++AVK++ K + KK
Sbjct: 113 QIGVGASGTVFVANVAGSTDVVAVKRMAFKT------------QPKK------------- 147
Query: 504 TSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQ-EGGNLNIFLEYVPGGSVSSMLNNY 562
+ L E+ ++K+ H N+V Y S + +L + ++Y+ GG+++ ++
Sbjct: 148 ---------EMLLTEIKVMKQYRHPNLVNYIESYLVDADDLWVVMDYLEGGNLTDVVVKT 198
Query: 563 GPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPLN 622
DE + ++ L L +LH+ +I+HRDIK N+L+ + G VK+TD G ++ P
Sbjct: 199 -ELDEGQIAAVLQECLKALHFLHRHSIVHRDIKSDNVLLGMNGEVKLTDMGFCAQIQP-- 255
Query: 623 KQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAIFK 682
+KR ++ G+ YWM+PE++ + K DIWS+G + +EM G+ P+ + ++AI+
Sbjct: 256 --GSKRDTVVGTPYWMSPEILNKKQYNYKVDIWSLGIMALEMIDGEPPYLRETPLKAIYL 313
Query: 683 IGTNIIPEIP--SWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
I N PEI +S E FL K +D +R + LL P+L
Sbjct: 314 IAQNGKPEIKQRDRLSSEFNNFLDKCLVVDPDQRADTTELLAHPFL 359
>CE09360 [Z] KOG0613 Projectin/twitchin and related proteins
Length = 2783
Score = 118 bits (296), Expect = 3e-26
Identities = 82/304 (26%), Positives = 142/304 (45%), Gaps = 46/304 (15%)
Query: 429 LPTKVEAPKSWLKGARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADES 488
LP ++A ++ +G G++G+VY TG+ A K V+++P V+
Sbjct: 187 LPNDLQA--KYIIHEELGKGAYGTVYRATEKATGKTWAAKMVQVRPGVKKENVI------ 238
Query: 489 KKAHSPGGGNTAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLE 548
HE++++ +LHHE ++ + + G + + E
Sbjct: 239 ----------------------------HEISMMNQLHHEKLLNLHEAFDMGNEMWLIEE 270
Query: 549 YVPGGSV-SSMLNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGG- 606
+V GG + +L + E V+++ QIL+G++++HK I+H D+K NIL+ K
Sbjct: 271 FVSGGELFEKILEDDSLMSEEEVRDYMHQILLGVSHMHKNQIVHLDLKPENILLKAKNSN 330
Query: 607 -VKITDFGISKKLSPLNKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMF 665
+KI DFG+++KL P + L G+ + APEVV D+W+VG + +
Sbjct: 331 ELKIIDFGLARKLDP----KKSVKLLFGTPEFCAPEVVNYQPVGLSTDMWTVGVISYVLL 386
Query: 666 TGKHPFPDFSQMQAIFKIGTNIIP-EIPSW--VSEEAKAFLFKSFELDYRKRPSSLGLLQ 722
+G PF S + + + + PSW VS+ AK F+ + D RKR S L+
Sbjct: 387 SGLSPFLGDSDEDTLANVSASDWDFDDPSWDDVSDLAKDFICRLMIKDKRKRMSVQDALR 446
Query: 723 EPWL 726
PW+
Sbjct: 447 HPWI 450
>CE20564 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 540
Score = 118 bits (295), Expect = 4e-26
Identities = 76/228 (33%), Positives = 122/228 (53%), Gaps = 6/228 (2%)
Query: 500 AVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSML 559
AVK + ++ + L +E++IL++ H NIV ++ S L + +E++ GGS++ ++
Sbjct: 276 AVKRMNLRKQQRRELLFNEVSILRQYQHPNIVRFFSSHLVDDELWVVMEFMEGGSLTDIV 335
Query: 560 NNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLS 619
EP + +RQ+L L +LH R +IHRDIK +IL+ G VK+TDFG +LS
Sbjct: 336 TATR-MTEPQIATISRQVLGALDFLHARKVIHRDIKSDSILLKRDGTVKLTDFGFCGQLS 394
Query: 620 PLNKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQA 679
++ +R SL G+ YW A EV+ + +ADIWS G +++EM G+ PF + QA
Sbjct: 395 ---EEVPRRRSLVGTPYWTAAEVIAREPYDTRADIWSFGIMLIEMVEGEPPFFNDQPFQA 451
Query: 680 IFKIGTNIIPEIP--SWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPW 725
+ +I + VS E L D KR + LL+ P+
Sbjct: 452 MKRIRDEHEARFSRHAKVSVELSELLSHCIVKDVNKRWPAKDLLRHPF 499
>CE05425 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 542
Score = 118 bits (295), Expect = 4e-26
Identities = 76/228 (33%), Positives = 122/228 (53%), Gaps = 6/228 (2%)
Query: 500 AVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSML 559
AVK + ++ + L +E++IL++ H NIV ++ S L + +E++ GGS++ ++
Sbjct: 278 AVKRMNLRKQQRRELLFNEVSILRQYQHPNIVRFFSSHLVDDELWVVMEFMEGGSLTDIV 337
Query: 560 NNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLS 619
EP + +RQ+L L +LH R +IHRDIK +IL+ G VK+TDFG +LS
Sbjct: 338 TATR-MTEPQIATISRQVLGALDFLHARKVIHRDIKSDSILLKRDGTVKLTDFGFCGQLS 396
Query: 620 PLNKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQA 679
++ +R SL G+ YW A EV+ + +ADIWS G +++EM G+ PF + QA
Sbjct: 397 ---EEVPRRRSLVGTPYWTAAEVIAREPYDTRADIWSFGIMLIEMVEGEPPFFNDQPFQA 453
Query: 680 IFKIGTNIIPEIP--SWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPW 725
+ +I + VS E L D KR + LL+ P+
Sbjct: 454 MKRIRDEHEARFSRHAKVSVELSELLSHCIVKDVNKRWPAKDLLRHPF 501
>Hs4826878 [T] KOG0582 Ste20-like serine/threonine protein kinase
Length = 527
Score = 117 bits (294), Expect = 5e-26
Identities = 79/231 (34%), Positives = 120/231 (51%), Gaps = 20/231 (8%)
Query: 512 IDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNY--------G 563
+D L E+ + + HH NIV+YY S L + ++ + GGSV ++ + G
Sbjct: 57 MDELLKEIQAMSQCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSG 116
Query: 564 PFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPLNK 623
DE + R++L GL YLHK IHRD+K NIL+ G V+I DFG+S L+
Sbjct: 117 VLDESTIATILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGD 176
Query: 624 -QQNK-RASLQGSVYWMAPEVVKQVVTTE-KADIWSVGCVIVEMFTGKHPFPDFSQMQAI 680
+NK R + G+ WMAPEV++QV + KADIWS G +E+ TG P+ + M+ +
Sbjct: 177 ITRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVL 236
Query: 681 FKIGTNIIPEIPSWVSEEAKAFLF-KSF--------ELDYRKRPSSLGLLQ 722
N P + + V ++ + KSF + D KRP++ LL+
Sbjct: 237 MLTLQNDPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLR 287
>At3g45790 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 376
Score = 117 bits (294), Expect = 5e-26
Identities = 99/323 (30%), Positives = 145/323 (44%), Gaps = 70/323 (21%)
Query: 433 VEAPKSWLKGARIGSGSFGSVYLGMN--AETGELMAVKQVELKPTAVTAGVVSIADESKK 490
V SW+K +G GS+GSVYL + A+T MA+K E+ +
Sbjct: 90 VRKSSSWIKSEFLGRGSYGSVYLATSKKAKTKTTMAIKSAEISRAS-------------- 135
Query: 491 AHSPGGGNTAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSS---------QEGG 541
+L E IL L IV YG E
Sbjct: 136 -----------------------SLMDEERILTRLSSPFIVRCYGHEIAREETLFGGERT 172
Query: 542 NLNIFLEYVPGGSVSSMLN-NYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANIL 600
N N+ LEY G S+ ++N N G E VK R IL GL Y+H+ NIIH DIK NIL
Sbjct: 173 NYNLILEYCSGKSLFDLVNSNLGGLSEKDVKLLARDILYGLDYIHRANIIHCDIKPENIL 232
Query: 601 I-DIKGGV-------KITDFGIS--KKLSPLNKQQNKRASLQGSVYWMAPEVVKQVVTTE 650
+ ++ + KI DFG++ K S K R +G+ +M+PE+++ +
Sbjct: 233 LAPVENRIRPNGYVAKIGDFGLALEKGSSEYEKASGHR---RGTTRYMSPELIRHGIVDY 289
Query: 651 KADIWSVGCVIVEMFTGKHPFPDFSQMQAI---FKIGTN-IIPEIPSWVSEEAKAFLFKS 706
D W+ GC ++EM TG+ + + S + ++ IG + IP IP W+SEEA+ FL +
Sbjct: 290 AVDTWAFGCTVLEMLTGQQVWGEHSDLGSVDWDILIGQSCYIPYIPDWLSEEAQHFLSRC 349
Query: 707 FELDYRKRPSSLGLLQEPWLNTV 729
+ D P+S ++ P L V
Sbjct: 350 LKRD----PASSCKMKYPTLYLV 368
>At3g46140 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 376
Score = 117 bits (292), Expect = 8e-26
Identities = 98/320 (30%), Positives = 141/320 (43%), Gaps = 66/320 (20%)
Query: 433 VEAPKSWLKGARIGSGSFGSVYLGMN--AETGELMAVKQVELKPTAVTAGVVSIADESKK 490
V SW+K +G GS+GSVYL + A+T MA+K E+ +
Sbjct: 90 VRKSSSWIKSEFLGRGSYGSVYLATSKKAKTKTTMAIKSAEISRAS-------------- 135
Query: 491 AHSPGGGNTAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSS---------QEGG 541
+L E IL L IV YG E
Sbjct: 136 -----------------------SLMDEERILTRLSSPFIVRCYGHEIAREETLFGGERT 172
Query: 542 NLNIFLEYVPGGSVSSMLN-NYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANI- 599
N N+ LEY G S+ ++N N G E VK R IL GL +H+ NIIH DIK NI
Sbjct: 173 NYNLILEYCSGKSLFDLVNDNLGGLSEKDVKLLARDILYGLDCIHRANIIHCDIKPENIF 232
Query: 600 LIDIKGGV-------KITDFGIS--KKLSPLNKQQNKRASLQGSVYWMAPEVVKQVVTTE 650
L ++ + KI DFG++ K S K R +G+ +M+PE+++ +
Sbjct: 233 LTPVENRIRPSGYVAKIGDFGLALEKGSSEYEKASGHR---RGTTRYMSPELIRHGIVDY 289
Query: 651 KADIWSVGCVIVEMFTGKHPFPDFSQMQAI---FKIGTN-IIPEIPSWVSEEAKAFLFKS 706
D W+ GC ++EM TG+ + + S + ++ IG + IP IP W+SEEA+ FL +
Sbjct: 290 AVDTWAFGCTVLEMLTGQQVWGEHSDLGSVDWDILIGQSCYIPYIPDWLSEEAQHFLSRC 349
Query: 707 FELDYRKRPSSLGLLQEPWL 726
+ D R LL P+L
Sbjct: 350 LKRDPASRWGIGALLNHPFL 369
>At3g08720 [RT] KOG0598 Ribosomal protein S6 kinase and related proteins
Length = 471
Score = 117 bits (292), Expect = 8e-26
Identities = 76/262 (29%), Positives = 132/262 (50%), Gaps = 43/262 (16%)
Query: 445 IGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKNT 504
+G G+FG VY +T E+ A+K ++
Sbjct: 146 VGQGAFGKVYQVRKKDTSEIYAMK-------------------------------VMRKD 174
Query: 505 SQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNYGP 564
+ + + ++ E +IL ++ H IV S Q L + L+++ GG + L + G
Sbjct: 175 KIVEKNHAEYMKAERDILTKIDHPFIVQLKYSFQTKYRLYLVLDFINGGHLFFQLYHQGL 234
Query: 565 FDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPLNKQ 624
F E L + +T +I+ +++LH++ I+HRD+K NIL+D+ G V +TDFG++K+ ++
Sbjct: 235 FREDLARVYTAEIVSAVSHLHEKGIMHRDLKPENILMDVDGHVMLTDFGLAKEF----EE 290
Query: 625 QNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAIFKIG 684
+ S+ G+ +MAPE+V+ + AD WSVG ++ EM TGK PF + + KI
Sbjct: 291 NTRSNSMCGTTEYMAPEIVRGKGHDKAADWWSVGILLYEMLTGKPPF-----LGSKGKIQ 345
Query: 685 TNIIPE---IPSWVSEEAKAFL 703
I+ + +P ++S EA A L
Sbjct: 346 QKIVKDKIKLPQFLSNEAHALL 367
>7290841 [D] KOG0591 NIMA (never in mitosis)-related G2-specific
serine/threonine protein kinase
Length = 735
Score = 117 bits (292), Expect = 8e-26
Identities = 82/292 (28%), Positives = 137/292 (46%), Gaps = 45/292 (15%)
Query: 443 ARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVK 502
A +G+GSFG+ Y + TGEL A K +
Sbjct: 23 AVMGNGSFGTCYKVRDKSTGELFAWKGM-------------------------------- 50
Query: 503 NTSQIHRKMIDALQHEMNILKELHHENIVTYYGS--SQEGGNLNIFLEYVPGGSVSSMLN 560
N ++ DAL E+++L++L H NIV YY ++E ++ I +E GG ++ ++
Sbjct: 51 NYDELDEAKCDALVSEISVLRQLQHPNIVQYYHHLVNREAKSVYIVMECCAGGDLAQIVQ 110
Query: 561 NYGP----FDEPLVKNFTRQILIGLAYLHKR----NIIHRDIKGANILIDIKGGVKITDF 612
F+EP + Q+ L H + I+HRDIK ANI +D G K+ DF
Sbjct: 111 RARSQRQRFEEPYIWRVLFQLCRALQVCHNKIPNGTILHRDIKPANIFLDAAGNAKLGDF 170
Query: 613 GISKKLSPLNKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFP 672
G+++ L + Q+ AS G+ ++M+PE+VK K+D+W+VGC++ EM + PF
Sbjct: 171 GLARML---RRDQSFAASFVGTPHYMSPELVKGRKYDRKSDVWAVGCLVYEMCALRPPFR 227
Query: 673 DFSQMQAIFKIGTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEP 724
+ Q KI IP+ S + + + +D+ +RP +++ P
Sbjct: 228 GRAFDQLSEKIAQGEFSRIPAIYSTDLQEIIAFMLAVDHEQRPGIEVIIRHP 279
>At5g25110 [T] KOG0583 Serine/threonine protein kinase
Length = 460
Score = 116 bits (291), Expect = 1e-25
Identities = 81/286 (28%), Positives = 134/286 (46%), Gaps = 37/286 (12%)
Query: 442 GARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAV 501
G +G G+FG VY G TGE +A+K +
Sbjct: 18 GRLLGKGTFGKVYYGKEITTGESVAIKII------------------------------- 46
Query: 502 KNTSQIHRK-MIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLN 560
N Q+ R+ M++ ++ E++I++ + H NIV + +EYV GG + S +
Sbjct: 47 -NKDQVKREGMMEQIKREISIMRLVRHPNIVELKEVMATKTKIFFIMEYVKGGELFSKIV 105
Query: 561 NYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSP 620
G E + + +Q++ + + H R + HRD+K N+L+D G +K++DFG+S L
Sbjct: 106 K-GKLKEDSARKYFQQLISAVDFCHSRGVSHRDLKPENLLVDENGDLKVSDFGLS-ALPE 163
Query: 621 LNKQQNKRASLQGSVYWMAPEVV-KQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQA 679
Q + G+ ++APEV+ K+ K DIWS G ++ + G PF D + M+
Sbjct: 164 QILQDGLLHTQCGTPAYVAPEVLRKKGYDGAKGDIWSCGIILYVLLAGFLPFQDENLMKM 223
Query: 680 IFKIGTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPW 725
KI + E P W S E+K + K +D KR S +++ PW
Sbjct: 224 YRKIFKSEF-EYPPWFSPESKRLISKLLVVDPNKRISIPAIMRTPW 268
>At5g40440 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 520
Score = 116 bits (290), Expect = 1e-25
Identities = 83/257 (32%), Positives = 138/257 (53%), Gaps = 11/257 (4%)
Query: 476 AVTAGVVSIADESKKAHSPGGGNTAVKNTSQIHRKMIDALQHEMNILKELH-HENIVTYY 534
A+ +G S+ + H P A+K + R+ L E+ L E HE +V ++
Sbjct: 88 AIGSGASSVVQRA--IHIPNHRILALKKINIFEREKRQQLLTEIRTLCEAPCHEGLVDFH 145
Query: 535 GS--SQEGGNLNIFLEYVPGGSVSSMLNNYGPFDEPLVKNFTRQILIGLAYLHK-RNIIH 591
G+ S + G ++I LEY+ GGS++ +L EP++ + ++L GL+YLH R+++H
Sbjct: 146 GAFYSPDSGQISIALEYMNGGSLADILKVTKKIPEPVLSSLFHKLLQGLSYLHGVRHLVH 205
Query: 592 RDIKGANILIDIKGGVKITDFGISKKLSPLNKQQNKRASLQGSVYWMAPEVVKQVVTTEK 651
RDIK AN+LI++KG KITDFGIS + L A+ G+V +M+PE ++ +
Sbjct: 206 RDIKPANLLINLKGEPKITDFGIS---AGLENSMAMCATFVGTVTYMSPERIRNDSYSYP 262
Query: 652 ADIWSVGCVIVEMFTGKHPF-PDFSQMQAIFKIGTNIIPEIPSW-VSEEAKAFLFKSFEL 709
ADIWS+G + E TG+ P+ + + + +I + P P S E +F+ +
Sbjct: 263 ADIWSLGLALFECGTGEFPYIANEGPVNLMLQILDDPSPTPPKQEFSPEFCSFIDACLQK 322
Query: 710 DYRKRPSSLGLLQEPWL 726
D RP++ LL P++
Sbjct: 323 DPDARPTADQLLSHPFI 339
>SPCC16C4.11 [R] KOG0594 Protein kinase PCTAIRE and related kinases
Length = 288
Score = 115 bits (289), Expect = 2e-25
Identities = 83/285 (29%), Positives = 144/285 (50%), Gaps = 57/285 (20%)
Query: 444 RIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKN 503
++G G++ VY G N TGE++A+K + + ADE G +TA++
Sbjct: 8 KLGEGTYAHVYKGQNRVTGEIVALKVIRID-----------ADE-------GTPSTAIR- 48
Query: 504 TSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSM--LNN 561
E++++KEL H NI++ Q L + EY+ M N
Sbjct: 49 --------------EISLMKELRHPNIMSLSDVLQTENKLMLVFEYMEKDLKKYMDTYGN 94
Query: 562 YGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLS-P 620
G VKNFT+Q+L G+++ H+ ++HRD+K N+LI+ +G +K+ DFG+++ + P
Sbjct: 95 QGALPPSQVKNFTQQLLKGISFCHENRVLHRDLKPQNLLINSRGELKLADFGLARSIGIP 154
Query: 621 LNKQQNKRASLQGSVYWMAPEV-VKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQA 679
+N N+ +L ++ AP+V + V + DIWSVGC++ EM TG+ F +
Sbjct: 155 VNTFSNEVVTL----WYRAPDVLLGSRVYSTSIDIWSVGCIMAEMATGRPLFAGSNNEDQ 210
Query: 680 IFKI-------------GTNIIPEI-PSWVSEEAK--AFLFKSFE 708
+ KI G +++PE P++ +A+ A+LF +F+
Sbjct: 211 LLKIFRLLGTPTEQSWPGISLLPEYKPTFPIYKAQDLAYLFPTFD 255
>At4g26070 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 354
Score = 115 bits (289), Expect = 2e-25
Identities = 84/291 (28%), Positives = 144/291 (48%), Gaps = 45/291 (15%)
Query: 445 IGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKNT 504
IG GS G+V L + T + A+K ++L T +S
Sbjct: 74 IGKGSSGNVQLVKHKLTQQFFALKVIQLNTEESTCRAIS--------------------- 112
Query: 505 SQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNYGP 564
E+ I +V+ Y S G ++I LE++ GGS++ +L G
Sbjct: 113 ------------QELRINLSSQCPYLVSCYQSFYHNGLVSIILEFMDGGSLADLLKKVGK 160
Query: 565 FDEPLVKNFTRQILIGLAYLH-KRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPLNK 623
E ++ +++L GL Y+H +R IIHRD+K +N+LI+ +G VKITDFG+SK L+ +
Sbjct: 161 VPENMLSAICKRVLRGLCYIHHERRIIHRDLKPSNLLINHRGEVKITDFGVSKILTSTSS 220
Query: 624 QQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPF--PDFSQ-MQAI 680
N S G+ +M+PE + + + K+DIWS+G V++E TGK P+ P+ + ++
Sbjct: 221 LAN---SFVGTYPYMSPERISGSLYSNKSDIWSLGLVLLECATGKFPYTPPEHKKGWSSV 277
Query: 681 FKIGTNIIPEIP-----SWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
+++ I+ P + S E +F+ + + D R R S+ LL+ ++
Sbjct: 278 YELVDAIVENPPPCAPSNLFSPEFCSFISQCVQKDPRDRKSAKELLEHKFV 328
>At3g08730 [RT] KOG0598 Ribosomal protein S6 kinase and related proteins
Length = 465
Score = 115 bits (289), Expect = 2e-25
Identities = 79/262 (30%), Positives = 133/262 (50%), Gaps = 43/262 (16%)
Query: 445 IGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKNT 504
+G G+FG VY ET E+ A+K + +K H
Sbjct: 140 VGKGAFGKVYQVRKKETSEIYAMKVM------------------RKDHI----------- 170
Query: 505 SQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNYGP 564
+ + + ++ E +IL ++ H IV S Q L + L+++ GG + L + G
Sbjct: 171 --MEKNHAEYMKAERDILTKIDHPFIVQLKYSFQTKYRLYLVLDFINGGHLFFQLYHQGL 228
Query: 565 FDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPLNKQ 624
F E L + +T +I+ +++LH++ I+HRD+K NIL+D G V +TDFG++K+ ++
Sbjct: 229 FREDLARVYTAEIVSAVSHLHEKGIMHRDLKPENILMDTDGHVMLTDFGLAKEF----EE 284
Query: 625 QNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAIFKIG 684
+ S+ G+ +MAPE+V+ + AD WSVG ++ EM TGK PF + + KI
Sbjct: 285 NTRSNSMCGTTEYMAPEIVRGKGHDKAADWWSVGILLYEMLTGKPPF-----LGSKGKIQ 339
Query: 685 TNIIPE---IPSWVSEEAKAFL 703
I+ + +P ++S EA A L
Sbjct: 340 QKIVKDKIKLPQFLSNEAHAIL 361
>At2g45490 [D] KOG0580 Serine/threonine protein kinase
Length = 288
Score = 115 bits (288), Expect = 2e-25
Identities = 88/288 (30%), Positives = 135/288 (46%), Gaps = 42/288 (14%)
Query: 442 GARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAV 501
G +G G FG VYL A++ ++A+K V ++ +K
Sbjct: 25 GRPLGKGKFGRVYLAREAKSKYIVALK-------------VIFKEQIEK----------- 60
Query: 502 KNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNN 561
+IH + L+ EM I L H NI+ +G + + + LEY GG + +L
Sbjct: 61 ---YKIHHQ----LRREMEIQTSLRHPNILRLFGWFHDNERIFLILEYAHGGELYGVLKQ 113
Query: 562 YGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPL 621
G E + + LAY H + +IHRDIK N+L+D +G +KI DFG S + S
Sbjct: 114 NGHLTEQQAATYIASLSQALAYCHGKCVIHRDIKPENLLLDHEGRLKIADFGWSVQSS-- 171
Query: 622 NKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQ---MQ 678
NKR ++ G++ ++APE+V+ D W++G + E G PF SQ +
Sbjct: 172 ----NKRKTMCGTLDYLAPEMVENRDHDYAVDNWTLGILCYEFLYGNPPFEAESQKDTFK 227
Query: 679 AIFKIGTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
I KI + P P+ VSEEAK + + D KR S ++Q PW+
Sbjct: 228 RILKIDLS-FPLTPN-VSEEAKNLISQLLVKDPSKRLSIEKIMQHPWI 273
>YJL164c [T] KOG0616 cAMP-dependent protein kinase catalytic subunit (PKA)
Length = 397
Score = 115 bits (287), Expect = 3e-25
Identities = 79/291 (27%), Positives = 131/291 (44%), Gaps = 43/291 (14%)
Query: 445 IGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKNT 504
+G+GSFG V+L + G A+K +K
Sbjct: 93 LGTGSFGRVHLIRSRHNGRYYAMK-------------------------------VLKKE 121
Query: 505 SQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNYGP 564
+ K ++ E +L + H I+ +G+ Q+ + + ++Y+ GG + S+L
Sbjct: 122 IVVRLKQVEHTNDERLMLSIVTHPFIIRMWGTFQDAQQIFMIMDYIEGGELFSLLRKSQR 181
Query: 565 FDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPLNKQ 624
F P+ K + ++ + L YLH ++II+RD+K NIL+D G +KITDFG +K + +
Sbjct: 182 FPNPVAKFYAAEVCLALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFAKYVPDVT-- 239
Query: 625 QNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAIFKIG 684
+L G+ ++APEVV + D WS G +I EM G PF D + M+ KI
Sbjct: 240 ----YTLCGTPDYIAPEVVSTKPYNKSIDWWSFGILIYEMLAGYTPFYDSNTMKTYEKI- 294
Query: 685 TNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSL-----GLLQEPWLNTVL 730
N P + +E+ K L + D +R +L + PW V+
Sbjct: 295 LNAELRFPPFFNEDVKDLLSRLITRDLSQRLGNLQNGTEDVKNHPWFKEVV 345
>Hs4506055 [T] KOG0616 cAMP-dependent protein kinase catalytic subunit (PKA)
Length = 351
Score = 115 bits (287), Expect = 3e-25
Identities = 81/274 (29%), Positives = 133/274 (47%), Gaps = 38/274 (13%)
Query: 445 IGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKNT 504
+G+GSFG V L + ETG A+K I D+ K
Sbjct: 50 LGTGSFGRVMLVKHKETGNHYAMK---------------ILDKQK--------------- 79
Query: 505 SQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNYGP 564
+ K I+ +E IL+ ++ +V S ++ NL + +EYVPGG + S L G
Sbjct: 80 -VVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGR 138
Query: 565 FDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPLNKQ 624
F EP + + QI++ YLH ++I+RD+K N+LID +G +++TDFG +K++
Sbjct: 139 FSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRV------ 192
Query: 625 QNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAIFKIG 684
+ + +L G+ ++APE++ + D W++G +I EM G PF +Q KI
Sbjct: 193 KGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIV 252
Query: 685 TNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSL 718
+ + PS S + K L ++D KR +L
Sbjct: 253 SGKV-RFPSHFSSDLKDLLRNLLQVDLTKRFGNL 285
>Hs4505373 [V] KOG1826 Ras GTPase activating protein RasGAP/neurofibromin
Length = 445
Score = 115 bits (287), Expect = 3e-25
Identities = 73/221 (33%), Positives = 114/221 (51%), Gaps = 14/221 (6%)
Query: 515 LQHEMNILKELHHENIVTYYGSSQEGGN--LNIFLEYVPGGSVSSMLNNYGP----FDEP 568
L E+N+L+EL H NIV YY + N L I +EY GG ++S++ DE
Sbjct: 52 LVSEVNLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEE 111
Query: 569 LVKNFTRQILIGLAYLHKRN-----IIHRDIKGANILIDIKGGVKITDFGISKKLSPLNK 623
V Q+ + L H+R+ ++HRD+K AN+ +D K VK+ DFG+++ L N
Sbjct: 112 FVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARIL---NH 168
Query: 624 QQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAIFKI 683
+ + G+ Y+M+PE + ++ EK+DIWS+GC++ E+ PF FSQ + KI
Sbjct: 169 DTSFAKTFVGTPYYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKI 228
Query: 684 GTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEP 724
IP S+E + + L RPS +L+ P
Sbjct: 229 REGKFRRIPYRYSDELNEIITRMLNLKDYHRPSVEEILENP 269
>SPAC2F3.15 [D] KOG0600 Cdc2-related protein kinase
Length = 593
Score = 114 bits (286), Expect = 4e-25
Identities = 81/257 (31%), Positives = 135/257 (52%), Gaps = 44/257 (17%)
Query: 444 RIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKN 503
+IG G++G VY +N TG+L+A+K++ L E +K P T V+
Sbjct: 282 QIGEGTYGKVYKAINTVTGDLVALKRIRL--------------EQEKDGFP---ITTVR- 323
Query: 504 TSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNYG 563
E+ IL+ L H+NIV E ++ + EY+ +LN+
Sbjct: 324 --------------EVKILQRLRHKNIVRLLEIMVEKSSVYMVFEYMDHDLTGVLLNSQL 369
Query: 564 PFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPLNK 623
F +K+ ++QI LAYLH R ++HRDIKG+NIL++ G +K DFG++ + + +K
Sbjct: 370 HFTPGNIKHLSKQIFEALAYLHHRGVLHRDIKGSNILLNNNGDLKFADFGLA-RFNTSSK 428
Query: 624 QQNKRASLQGSVYWMAPEVVKQVVTTEKA-DIWSVGCVIVEMFTGKHPF----PDFSQMQ 678
N + ++++ PE++ + A DIWS GC+++E+FTGK PF + SQ++
Sbjct: 429 SANYTNRVI-TLWFRPPELLLGETAYDTAVDIWSAGCIVMELFTGK-PFFQGRDEISQLE 486
Query: 679 AIF-KIGTNIIPEIPSW 694
I+ +GT P++ SW
Sbjct: 487 VIYDMMGT---PDVHSW 500
>Hs4758016 [D] KOG0575 Polo-like serine/threonine protein kinase
Length = 607
Score = 114 bits (286), Expect = 4e-25
Identities = 80/288 (27%), Positives = 135/288 (46%), Gaps = 35/288 (12%)
Query: 429 LPTKVEAPKSWLKGARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADES 488
L T + +++LKG +G G F Y + ETG AVK + A
Sbjct: 13 LITDPRSGRTYLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVA------------ 60
Query: 489 KKAHSPGGGNTAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLE 548
K H + N ++HR +L H +IV + ++ N+ IFLE
Sbjct: 61 -KPHQ----REKILNEIELHR--------------DLQHRHIVRFSHHFEDADNIYIFLE 101
Query: 549 YVPGGSVSSMLNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVK 608
S++ + EP V+ + RQIL GL YLH+R I+HRD+K N I +K
Sbjct: 102 LCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFITENMELK 161
Query: 609 ITDFGISKKLSPLNKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGK 668
+ DFG++ +L P + ++ ++ G+ ++APEV+ + +AD+WS+GCV+ + G
Sbjct: 162 VGDFGLAARLEP---PEQRKKTICGTPNYVAPEVLLRQGHGPEADVWSLGCVMYTLLCGS 218
Query: 669 HPFPDFSQMQAIFKIGTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPS 716
PF + + ++ ++ + +P+ +S A+ L R RPS
Sbjct: 219 PPF-ETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRDRPS 265
>At2g30360 [T] KOG0583 Serine/threonine protein kinase
Length = 435
Score = 114 bits (285), Expect = 5e-25
Identities = 75/285 (26%), Positives = 136/285 (47%), Gaps = 33/285 (11%)
Query: 442 GARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAV 501
G +G G+F V+ + TG+ +AVK I ++ K +P N
Sbjct: 24 GKLLGCGAFAKVFHARDRRTGQSVAVK---------------ILNKKKLLTNPALANN-- 66
Query: 502 KNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNN 561
++ E++I++ L H NIV + + +E+V GG + + ++
Sbjct: 67 -------------IKREISIMRRLSHPNIVKLHEVMATKSKIFFAMEFVKGGELFNKISK 113
Query: 562 YGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPL 621
+G E L + + +Q++ + Y H R + HRD+K N+LID G +K++DFG+S L+
Sbjct: 114 HGRLSEDLSRRYFQQLISAVGYCHARGVYHRDLKPENLLIDENGNLKVSDFGLS-ALTDQ 172
Query: 622 NKQQNKRASLQGSVYWMAPEVV-KQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAI 680
+ +L G+ ++APE++ K+ K D+WS G V+ + G PF D + M
Sbjct: 173 IRPDGLLHTLCGTPAYVAPEILSKKGYEGAKVDVWSCGIVLFVLVAGYLPFNDPNVMNMY 232
Query: 681 FKIGTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPW 725
KI P W+S + K F+ + +++ R + +L++PW
Sbjct: 233 KKIYKGEY-RFPRWMSPDLKRFVSRLLDINPETRITIDEILKDPW 276
>Hs7706401 [T] KOG0577 Serine/threonine protein kinase
Length = 1235
Score = 114 bits (284), Expect = 7e-25
Identities = 83/283 (29%), Positives = 130/283 (45%), Gaps = 44/283 (15%)
Query: 445 IGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKNT 504
IG GSFG+VY + E++A+K++ +
Sbjct: 34 IGHGSFGAVYFARDVRNSEVVAIKKMSY------------------------------SG 63
Query: 505 SQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNYGP 564
Q + K D ++ E+ L++L H N + Y G + +EY G + + + P
Sbjct: 64 KQSNEKWQDIIK-EVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHKKP 122
Query: 565 FDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPLNKQ 624
E + T L GLAYLH N+IHRD+K NIL+ G VK+ DFG + ++P N
Sbjct: 123 LQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPAN-- 180
Query: 625 QNKRASLQGSVYWMAPEVVKQVVTTE---KADIWSVGCVIVEMFTGKHPFPDFSQMQAIF 681
S G+ YWMAPEV+ + + K D+WS+G +E+ K P + + M A++
Sbjct: 181 -----SFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALY 235
Query: 682 KIGTNIIPEIPS--WVSEEAKAFLFKSFELDYRKRPSSLGLLQ 722
I N P + S W SE + F+ + + RP+S LL+
Sbjct: 236 HIAQNESPVLQSGHW-SEYFRNFVDSCLQKIPQDRPTSEVLLK 277
>Hs4759208 [T] KOG0577 Serine/threonine protein kinase
Length = 1049
Score = 114 bits (284), Expect = 7e-25
Identities = 83/283 (29%), Positives = 130/283 (45%), Gaps = 44/283 (15%)
Query: 445 IGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKNT 504
IG GSFG+VY + E++A+K++ +
Sbjct: 34 IGHGSFGAVYFARDVRNSEVVAIKKMSY------------------------------SG 63
Query: 505 SQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNYGP 564
Q + K D ++ E+ L++L H N + Y G + +EY G + + + P
Sbjct: 64 KQSNEKWQDIIK-EVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHKKP 122
Query: 565 FDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPLNKQ 624
E + T L GLAYLH N+IHRD+K NIL+ G VK+ DFG + ++P N
Sbjct: 123 LQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPAN-- 180
Query: 625 QNKRASLQGSVYWMAPEVVKQVVTTE---KADIWSVGCVIVEMFTGKHPFPDFSQMQAIF 681
S G+ YWMAPEV+ + + K D+WS+G +E+ K P + + M A++
Sbjct: 181 -----SFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALY 235
Query: 682 KIGTNIIPEIPS--WVSEEAKAFLFKSFELDYRKRPSSLGLLQ 722
I N P + S W SE + F+ + + RP+S LL+
Sbjct: 236 HIAQNESPVLQSGHW-SEYFRNFVDSCLQKIPQDRPTSEVLLK 277
>Hs4507831 [OUT] KOG0595 Serine/threonine-protein kinase involved in autophagy
Length = 1050
Score = 114 bits (284), Expect = 7e-25
Identities = 70/224 (31%), Positives = 110/224 (48%), Gaps = 15/224 (6%)
Query: 515 LQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNYGPFDEPLVKNFT 574
L E+ ILKEL HENIV Y + ++ + +EY GG ++ L+ E ++ F
Sbjct: 60 LGKEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFL 119
Query: 575 RQILIGLAYLHKRNIIHRDIKGANILIDIKGG---------VKITDFGISKKLSPLNKQQ 625
+QI + LH + IIHRD+K NIL+ G VKI DFG ++ L +
Sbjct: 120 QQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYL----QSN 175
Query: 626 NKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFS--QMQAIFKI 683
A+L GS +MAPEV+ KAD+WS+G ++ + TGK PF S ++ ++
Sbjct: 176 MMAATLCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEK 235
Query: 684 GTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWLN 727
++P IP S + L + +++ R P+L+
Sbjct: 236 NKTLVPTIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFLD 279
>YLR096w [T] KOG0583 Serine/threonine protein kinase
Length = 1147
Score = 113 bits (283), Expect = 9e-25
Identities = 82/284 (28%), Positives = 134/284 (46%), Gaps = 11/284 (3%)
Query: 445 IGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKNT 504
+G+GS G V L + +T E+ +K V A S+ ++ K
Sbjct: 105 VGAGSMGKVKLVKHRQTKEICVIKIVNRASKAYLHKQHSLPSPKNESEILERQKRLEKEI 164
Query: 505 SQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNYGP 564
++ R + E ++ + L+H +I + + + EYV GG + + +G
Sbjct: 165 ARDKRTV-----REASLGQILYHPHICRLFEMCTMSNHFYMLFEYVSGGQLLDYIIQHGS 219
Query: 565 FDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPLNKQ 624
E + F R I L YLH NI+HRD+K NI+I G +KI DFG+S + KQ
Sbjct: 220 LKEHHARKFARGIASALQYLHANNIVHRDLKIENIMISSSGEIKIIDFGLS-NIFDYRKQ 278
Query: 625 QNKRASLQGSVYWMAPEVVK-QVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAIFKI 683
+ + GS+Y+ APE++K Q T + DIWS G V+ + GK PF D + KI
Sbjct: 279 LH---TFCGSLYFAAPELLKAQPYTGPEVDIWSFGIVLYVLVCGKVPFDDENSSILHEKI 335
Query: 684 GTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWLN 727
+ + PS +S E + L + +D +R + +++ PW+N
Sbjct: 336 KKGKV-DYPSHLSIEVISLLTRMIVVDPLRRATLKNVVEHPWMN 378
>Hs7657526 [T] KOG0603 Ribosomal protein S6 kinase
Length = 745
Score = 113 bits (283), Expect = 9e-25
Identities = 89/279 (31%), Positives = 138/279 (48%), Gaps = 39/279 (13%)
Query: 445 IGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKNT 504
+G GSFG V+L K T AG + KKA ++K
Sbjct: 79 LGQGSFGKVFLVR---------------KKTGPDAGQLYAMKVLKKA--------SLKVR 115
Query: 505 SQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNYGP 564
++ KM E +IL E++H IV + + Q G L + L+++ GG V + L+
Sbjct: 116 DRVRTKM------ERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVL 169
Query: 565 FDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPLNKQ 624
F E VK + ++ + L +LH+ I++RD+K NIL+D G +K+TDFG+SK+ Q
Sbjct: 170 FTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGLSKESV---DQ 226
Query: 625 QNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQ---MQAIF 681
+ K S G+V +MAPEVV + ++ AD WS G ++ EM TG PF + M I
Sbjct: 227 EKKAYSFCGTVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMIL 286
Query: 682 KIGTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGL 720
K +P ++S EA++ L F+ + R S G+
Sbjct: 287 KAKLG----MPQFLSAEAQSLLRMLFKRNPANRLGSEGV 321
Score = 66.6 bits (161), Expect = 1e-10
Identities = 67/284 (23%), Positives = 123/284 (42%), Gaps = 30/284 (10%)
Query: 456 GMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKNTSQIHRKMIDAL 515
G A+ GE+ +K+ GV S + + H+ AVK + R + +
Sbjct: 417 GNAAQFGEVYELKE--------DIGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPSEEI 468
Query: 516 QHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNYGPFDEPLVKNFTR 575
+ +++ H NI+T +G + + + + GG + + F E +
Sbjct: 469 EI---LMRYGQHPNIITLKDVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILY 525
Query: 576 QILIGLAYLHKRNIIHRDIKGANILIDIKG----GVKITDFGISKKLSPLNKQQNKRASL 631
I + YLH + ++HRD+K +NIL + ++I DFG +K+L + + L
Sbjct: 526 VISKTVDYLHCQGVVHRDLKPSNILYMDESASADSIRICDFGFAKQL------RGENGLL 579
Query: 632 QGSVY---WMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPF---PDFSQMQAIFKIGT 685
Y ++APEV+ Q DIWS+G + M G PF P+ + + + +IG
Sbjct: 580 LTPCYTANFVAPEVLMQQGYDAACDIWSLGVLFYTMLAGYTPFANGPNDTPEEILLRIGN 639
Query: 686 NIIP-EIPSW--VSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
+W +S+ AK L +D +R ++ +L+ W+
Sbjct: 640 GKFSLSGGNWDNISDGAKDLLSHMLHMDPHQRYTAEQILKHSWI 683
>Hs15619015 [T] KOG0616 cAMP-dependent protein kinase catalytic subunit (PKA)
Length = 351
Score = 113 bits (283), Expect = 9e-25
Identities = 72/244 (29%), Positives = 126/244 (51%), Gaps = 10/244 (4%)
Query: 478 TAGVVSIADESKKAHSPGGGNTAVKNTSQ---IHRKMIDALQHEMNILKELHHENIVTYY 534
T G+ S H GG+ A+K ++ + K ++ + +E IL+ + +V
Sbjct: 49 TLGMGSFGRVMLVRHQETGGHYAMKILNKQKVVKMKQVEHILNEKRILQAIDFPFLVKLQ 108
Query: 535 GSSQEGGNLNIFLEYVPGGSVSSMLNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDI 594
S ++ L + +EYVPGG + S L G F EP + Q+++ + YLH ++IHRD+
Sbjct: 109 FSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPHACFYAAQVVLAVQYLHSLDLIHRDL 168
Query: 595 KGANILIDIKGGVKITDFGISKKLSPLNKQQNKRASLQGSVYWMAPEVVKQVVTTEKADI 654
K N+LID +G +++TDFG +K++ + + +L G+ ++APE++ + D
Sbjct: 169 KPENLLIDQQGYLQVTDFGFAKRV------KGRTWTLCGTPEYLAPEIILSKGYNKAVDW 222
Query: 655 WSVGCVIVEMFTGKHPFPDFSQMQAIFKIGTNIIPEIPSWVSEEAKAFLFKSFELDYRKR 714
W++G +I EM G PF +Q KI + + PS +S + K L ++D KR
Sbjct: 223 WALGVLIYEMAVGFPPFYADQPIQIYEKIVSGRV-RFPSKLSSDLKHLLRSLLQVDLTKR 281
Query: 715 PSSL 718
+L
Sbjct: 282 FGNL 285
>YKL166c [T] KOG0616 cAMP-dependent protein kinase catalytic subunit (PKA)
Length = 398
Score = 113 bits (282), Expect = 1e-24
Identities = 78/291 (26%), Positives = 132/291 (44%), Gaps = 43/291 (14%)
Query: 445 IGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKNT 504
+G+GSFG V+L + G A+K +K
Sbjct: 94 LGTGSFGRVHLIRSNHNGRFYALK-------------------------------TLKKH 122
Query: 505 SQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNYGP 564
+ + K ++ E +L + H I+ +G+ Q+ + + ++Y+ GG + S+L
Sbjct: 123 TIVKLKQVEHTNDERRMLSIVSHPFIIRMWGTFQDSQQVFMVMDYIEGGELFSLLRKSQR 182
Query: 565 FDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPLNKQ 624
F P+ K + ++ + L YLH ++II+RD+K NIL+D G +KITDFG +K + +
Sbjct: 183 FPNPVAKFYAAEVCLALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFAKYVPDVT-- 240
Query: 625 QNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAIFKIG 684
+L G+ ++APEVV + D WS G +I EM G PF + + M+ I
Sbjct: 241 ----YTLCGTPDYIAPEVVSTKPYNKSVDWWSFGVLIYEMLAGYTPFYNSNTMKTYENI- 295
Query: 685 TNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSL-----GLLQEPWLNTVL 730
N + P + +A+ L K D +R +L + PW N V+
Sbjct: 296 LNAELKFPPFFHPDAQDLLKKLITRDLSERLGNLQNGSEDVKNHPWFNEVI 346
>CE24761 [D] KOG0580 Serine/threonine protein kinase
Length = 305
Score = 113 bits (282), Expect = 1e-24
Identities = 79/291 (27%), Positives = 130/291 (44%), Gaps = 41/291 (14%)
Query: 442 GARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAV 501
G +G G FGSVYL +TG +V K ++ GV
Sbjct: 33 GRPLGKGKFGSVYLA-RTKTGHFHVAIKVLFKSQLISGGVE------------------- 72
Query: 502 KNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNN 561
L+ E+ I L+H NI+ Y + + + LEY PGG + L
Sbjct: 73 -----------HQLEREIEIQSHLNHPNIIKLYTYFWDAKKIYLVLEYAPGGEMYKQLTV 121
Query: 562 YGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPL 621
F EP + +I L+Y H++N+IHRDIK N+LI +G +KI DFG S +
Sbjct: 122 SKRFSEPTAAKYMYEIADALSYCHRKNVIHRDIKPENLLIGSQGELKIGDFGWS-----V 176
Query: 622 NKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPF--PDFSQMQA 679
+ NKR ++ G++ ++ PE+V ++ D+W++G + E GK PF D S+ A
Sbjct: 177 HAPSNKRQTMCGTMDYLPPEMVNGADHSDAVDLWAIGVLCYEFLVGKPPFEHEDQSKTYA 236
Query: 680 IFKIGTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWLNTVL 730
K P+ V + A+ + + +D + R + + + W+ ++
Sbjct: 237 AIKAARFTYPDS---VKKGARDLIGRLLVVDPKARCTLEQVKEHYWIQGMM 284
>At3g21220 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 348
Score = 112 bits (281), Expect = 2e-24
Identities = 92/310 (29%), Positives = 146/310 (46%), Gaps = 51/310 (16%)
Query: 428 SLPTKVEAPKSWL---KGARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSI 484
++ T + A KS + RIGSG+ G+VY ++ T A+K +
Sbjct: 56 AISTNISAAKSLSELERVNRIGSGAGGTVYKVIHTPTSRPFALKVIY------------- 102
Query: 485 ADESKKAHSPGGGNTAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLN 544
GN QI R E+ IL+ + H N+V + G +
Sbjct: 103 ------------GNHEDTVRRQICR--------EIEILRSVDHPNVVKCHDMFDHNGEIQ 142
Query: 545 IFLEYVPGGSVSSMLNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIK 604
+ LE++ GS L + E + + +RQIL GLAYLH+R+I+HRDIK +N+LI+
Sbjct: 143 VLLEFMDQGS----LEGAHIWQEQELADLSRQILSGLAYLHRRHIVHRDIKPSNLLINSA 198
Query: 605 GGVKITDFGISKKLSPLNKQQNKRASLQGSVYWMAPEVVKQVVTTEK-----ADIWSVGC 659
VKI DFG+S+ L+ N S G++ +M+PE + + + D+WS+G
Sbjct: 199 KNVKIADFGVSRILAQTMDPCN---SSVGTIAYMSPERINTDLNHGRYDGYAGDVWSLGV 255
Query: 660 VIVEMFTGKHPFPDFSQ---MQAIFKIGTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPS 716
I+E + G+ PF Q + I + PE P+ S+E + F+ + D KR S
Sbjct: 256 SILEFYLGRFPFAVSRQGDWASLMCAICMSQPPEAPATASQEFRHFVSCCLQSDPPKRWS 315
Query: 717 SLGLLQEPWL 726
+ LLQ P++
Sbjct: 316 AQQLLQHPFI 325
>SPCC4G3.08 [RT] KOG0598 Ribosomal protein S6 kinase and related proteins
Length = 436
Score = 112 bits (280), Expect = 2e-24
Identities = 75/270 (27%), Positives = 129/270 (47%), Gaps = 35/270 (12%)
Query: 445 IGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKNT 504
+G GS+G V L TG L A KQ++ K +
Sbjct: 97 LGRGSYGKVLLVKQKNTGRLFAQKQLK------------------------------KAS 126
Query: 505 SQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNYGP 564
+ K ++ ++E IL+E+ H I Y + Q+ L + L+Y PGG + S L
Sbjct: 127 IVLRAKGLEQTKNERQILEEVRHPFICRLYYAFQDHDRLYLILQYAPGGELFSHLAEQRM 186
Query: 565 FDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPLNKQ 624
E +V +T ++ + L +LHK I++RD+K N L+D +G + +TDFG+SK + +
Sbjct: 187 LPEDVVAFYTAELTLALIHLHKLGIVYRDLKPENCLLDAEGHILLTDFGLSK----VAEN 242
Query: 625 QNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAIFKIG 684
S G+ + APE++ + D WS+G +I ++ TG PF + + + KI
Sbjct: 243 GADCRSFVGTEEYCAPEILLEQPYDHAVDWWSMGILIFDLLTGSPPFTANNHKRIMEKI- 301
Query: 685 TNIIPEIPSWVSEEAKAFLFKSFELDYRKR 714
T P IP +V+ +A+ + K + + ++R
Sbjct: 302 TRAKPNIPFYVTSDARDIINKFLKKNPKQR 331
>At2g25090 [T] KOG0583 Serine/threonine protein kinase
Length = 469
Score = 112 bits (280), Expect = 2e-24
Identities = 82/291 (28%), Positives = 133/291 (45%), Gaps = 38/291 (13%)
Query: 442 GARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAV 501
G +G+G+F VY G TG+ +A+K + KK H
Sbjct: 18 GRLLGTGNFAKVYHGTEISTGDDVAIKVI------------------KKDH-------VF 52
Query: 502 KNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNN 561
K R M++ ++ E+ +++ L H N+V + +EYV GG + M++
Sbjct: 53 KR-----RGMMEQIEREIAVMRLLRHPNVVELREVMATKKKIFFVMEYVNGGELFEMIDR 107
Query: 562 YGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPL 621
G E L + + +Q++ + + H R + HRDIK N+L+D +G +K+TDFG+S + P
Sbjct: 108 DGKLPEDLARKYFQQLISAVDFCHSRGVFHRDIKPENLLLDGEGDLKVTDFGLSALMMPE 167
Query: 622 NKQQNKRASLQ------GSVYWMAPEVVK-QVVTTEKADIWSVGCVIVEMFTGKHPFPDF 674
+ +S G+ ++APEV++ + ADIWS G V+ + G PF D
Sbjct: 168 GLGGRRGSSDDLLHTRCGTPAYVAPEVLRNKGYDGAMADIWSCGIVLYALLAGFLPFIDE 227
Query: 675 SQMQAIFKIGTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPW 725
+ M KI E P W S E+K L + D +R S + PW
Sbjct: 228 NVMTLYTKI-FKAECEFPPWFSLESKELLSRLLVPDPEQRISMSEIKMIPW 277
>Hs20547878 [R] KOG0589 Serine/threonine protein kinase
Length = 758
Score = 112 bits (279), Expect = 3e-24
Identities = 67/195 (34%), Positives = 104/195 (52%), Gaps = 6/195 (3%)
Query: 539 EGGNLNIFLEYVPGGSVSSMLNNYGP--FDEPLVKNFTRQILIGLAYLHKRNIIHRDIKG 596
E G L I +EY GG + +N F E + + QI +GL ++H R I+HRDIK
Sbjct: 48 ENGRLFIVMEYCDGGDLMKRINRQRGVLFSEDQILGWFVQISLGLKHIHDRKILHRDIKA 107
Query: 597 ANILIDIKGGV-KITDFGISKKLSPLNKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIW 655
NI + G V K+ DFGI++ L+ N + R + G+ Y+++PE+ + K DIW
Sbjct: 108 QNIFLSKNGMVAKLGDFGIARVLN--NSMELARTCI-GTPYYLSPEICQNKPYNNKTDIW 164
Query: 656 SVGCVIVEMFTGKHPFPDFSQMQAIFKIGTNIIPEIPSWVSEEAKAFLFKSFELDYRKRP 715
S+GCV+ E+ T KHPF + Q + KI I S E + + + F++ R RP
Sbjct: 165 SLGCVLYELCTLKHPFEGNNLQQLVLKICQAHFAPISPGFSRELHSLISQLFQVSPRDRP 224
Query: 716 SSLGLLQEPWLNTVL 730
S +L+ P+L ++
Sbjct: 225 SINSILKRPFLENLI 239
>Hs19923570 [T] KOG0603 Ribosomal protein S6 kinase
Length = 733
Score = 112 bits (279), Expect = 3e-24
Identities = 88/273 (32%), Positives = 140/273 (51%), Gaps = 51/273 (18%)
Query: 445 IGSGSFGSVYLGMN---AETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAV 501
+G GS+G V+L ++ G+L A+K + KKA +
Sbjct: 65 LGQGSYGKVFLVRKVKGSDAGQLYAMKVL------------------KKA--------TL 98
Query: 502 KNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNN 561
K ++ KM E +IL E++H IV + + Q G L + L+++ GG + + L+
Sbjct: 99 KVRDRVRSKM------ERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSK 152
Query: 562 YGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPL 621
F E VK + ++ + L +LH II+RD+K NIL+D +G +KITDFG+SK+
Sbjct: 153 EVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAI-- 210
Query: 622 NKQQNKRA-SLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPF--PDFSQMQ 678
+KRA S G++ +MAPEVV + T+ AD WS G ++ EM TG PF D +
Sbjct: 211 --DHDKRAYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETM 268
Query: 679 AIF---KIGTNIIPEIPSWVSEEAKAFLFKSFE 708
A+ K+G +P ++S EA++ L F+
Sbjct: 269 ALILKAKLG------MPQFLSGEAQSLLRALFK 295
Score = 79.7 bits (195), Expect = 1e-14
Identities = 59/219 (26%), Positives = 106/219 (47%), Gaps = 19/219 (8%)
Query: 521 ILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNYGPFDEPLVKNFTRQILIG 580
+L+ H NI+T +G + + +E + GG + + F E + I
Sbjct: 460 LLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKT 519
Query: 581 LAYLHKRNIIHRDIKGANILIDIKGG----VKITDFGISKKLSPLNKQQNKRASLQGSVY 636
+ YLH + ++HRD+K +NIL + G +++ DFG +K+L N L Y
Sbjct: 520 MDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGN------GLLMTPCY 573
Query: 637 ---WMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPF---PDFSQMQAIFKIGT-NIIP 689
++APEV+K+ DIWS+G ++ M G PF PD + + + +IG+
Sbjct: 574 TANFVAPEVLKRQGYDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYAL 633
Query: 690 EIPSW--VSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
+W +S+ AK + K +D +R +++ +L+ PW+
Sbjct: 634 SGGNWDSISDAAKDVVSKMLHVDPHQRLTAMQVLKHPWV 672
>At5g62310 [TR] KOG0606 Microtubule-associated serine/threonine kinase and
related proteins
Length = 1168
Score = 112 bits (279), Expect = 3e-24
Identities = 82/296 (27%), Positives = 135/296 (44%), Gaps = 71/296 (23%)
Query: 445 IGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKNT 504
I G+FG V+L TG+L A+K +K
Sbjct: 760 ISRGAFGRVFLAKKRATGDLFAIK-------------------------------VLKKA 788
Query: 505 SQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNYGP 564
I + ++++ E NIL + + +V ++ S NL + +EY+ GG + S+L N G
Sbjct: 789 DMIRKNAVESILAERNILISVRNPFVVRFFYSFTCRENLYLVMEYLNGGDLFSLLRNLGC 848
Query: 565 FDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPLN-- 622
DE + + + ++++ L YLH NIIHRD+K N+LI+ G +K+TDFG+SK + +N
Sbjct: 849 LDEDMARIYIAEVVLALEYLHSVNIIHRDLKPDNLLINQDGHIKLTDFGLSK-VGLINST 907
Query: 623 ---------------------------KQQNKRASLQGSVYWMAPEVVKQVVTTEKADIW 655
K K+ ++ G+ ++APE++ + + AD W
Sbjct: 908 DDLSGESSLGNSGFFAEDGSKAQHSQGKDSRKKHAVVGTPDYLAPEILLGMGHGKTADWW 967
Query: 656 SVGCVIVEMFTGKHPFPDFSQMQAIFKIGTNII------PEIPSWVSEEAKAFLFK 705
SVG ++ E+ G PF + Q IF+ NII P +P +S EA + K
Sbjct: 968 SVGVILFEVLVGIPPF-NAETPQQIFE---NIINRDIPWPNVPEEISYEAHDLINK 1019
>At5g10930 [T] KOG0583 Serine/threonine protein kinase
Length = 445
Score = 112 bits (279), Expect = 3e-24
Identities = 81/286 (28%), Positives = 132/286 (45%), Gaps = 34/286 (11%)
Query: 442 GARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAV 501
G +G G+F VY G GE +A+K + ++ + PG
Sbjct: 15 GRLLGKGTFAKVYYGKEIIGGECVAIK---------------VINKDQVMKRPG------ 53
Query: 502 KNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNN 561
M++ ++ E++I+K + H NIV + +E+V GG + ++
Sbjct: 54 ---------MMEQIKREISIMKLVRHPNIVELKEVMATKTKIFFVMEFVKGGELFCKISK 104
Query: 562 YGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPL 621
G E + + +Q++ + Y H R + HRD+K N+L+D G +KI+DFG+S L
Sbjct: 105 -GKLHEDAARRYFQQLISAVDYCHSRGVSHRDLKPENLLLDENGDLKISDFGLS-ALPEQ 162
Query: 622 NKQQNKRASLQGSVYWMAPEVVKQV-VTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAI 680
Q + G+ ++APEV+K+ KADIWS G V+ + G PF D + M
Sbjct: 163 ILQDGLLHTQCGTPAYVAPEVLKKKGYDGAKADIWSCGVVLYVLLAGCLPFQDENLMNMY 222
Query: 681 FKIGTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
KI E P W S EA+ + K +D +R S +++ PWL
Sbjct: 223 RKIFRADF-EFPPWFSPEARRLISKLLVVDPDRRISIPAIMRTPWL 267
>7301213 [R] KOG0589 Serine/threonine protein kinase
Length = 841
Score = 112 bits (279), Expect = 3e-24
Identities = 77/280 (27%), Positives = 133/280 (47%), Gaps = 39/280 (13%)
Query: 445 IGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKNT 504
+G GSFG L G + KQ+ L SP G + A+
Sbjct: 111 VGQGSFGIAILYRRKSDGHQIVFKQINLSEL-----------------SPPGRDLAM--- 150
Query: 505 SQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSML-NNYG 563
+E+++ +LHH NIV+Y GS + L I +EY GG+++ ++ G
Sbjct: 151 ------------NEVDVFSKLHHPNIVSYLGSFIKDNTLLIEMEYADGGTLAQIIAERQG 198
Query: 564 P--FDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPL 621
F E + QI + Y+H NI+HRD+K AN+ ++ +G VKI DFGISK ++
Sbjct: 199 KLHFPERYIIAVFEQISSAINYMHSENILHRDLKTANVFLNRRGIVKIGDFGISKIMNTK 258
Query: 622 NKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAIF 681
Q ++ G+ Y+ +PE+ + K+DIW++GC++ EM K F + + +
Sbjct: 259 IHAQ----TVLGTPYYFSPEMCEGKEYDNKSDIWALGCILGEMCCLKKTFAASNLSELVT 314
Query: 682 KIGTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLL 721
KI +PS + ++ + +++ +RP++ +L
Sbjct: 315 KIMAGNYTPVPSGYTSGLRSLMSNLLQVEAPRRPTASEVL 354
>7298323 [D] KOG0590 Checkpoint kinase and related serine/threonine protein
kinases
Length = 514
Score = 112 bits (279), Expect = 3e-24
Identities = 71/242 (29%), Positives = 119/242 (48%), Gaps = 40/242 (16%)
Query: 434 EAPKSWLKGARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHS 493
E + W +G G++G V L +N +TGE +A+K V+LK
Sbjct: 17 EFVEGWTLAQTLGEGAYGEVKLLINRQTGEAVAMKMVDLKK------------------- 57
Query: 494 PGGGNTAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGG 553
H ++++ E+ I K L ++I+ ++G +G IFLEY GG
Sbjct: 58 --------------HPDAANSVRKEVCIQKMLQDKHILRFFGKRSQGSVEYIFLEYAAGG 103
Query: 554 SVSSMLNNYGPFDEPL--VKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITD 611
+ + P + + Q+L GL YLH+R I HRD+K N+L+D VKI+D
Sbjct: 104 ELFDRIGEEPDVGMPQHEAQRYFTQLLSGLNYLHQRGIAHRDLKPENLLLDEHDNVKISD 163
Query: 612 FGISKKLSPLNKQQ--NKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKH 669
FG++ K++ +KR G++ ++APEV+++ + AD+WS G ++V M G+
Sbjct: 164 FGMATMFRCKGKERLLDKRC---GTLPYVAPEVLQKAYHAQPADLWSCGVILVTMLAGEL 220
Query: 670 PF 671
P+
Sbjct: 221 PW 222
>At5g03730 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 821
Score = 111 bits (278), Expect = 3e-24
Identities = 74/229 (32%), Positives = 123/229 (53%), Gaps = 11/229 (4%)
Query: 496 GGNTAVKNTSQ--IHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGG 553
G + AVK + H + ++ E+ I+K L H NIV + G+ + NL+I EY+ G
Sbjct: 572 GSDVAVKILMEQDFHAERVNEFLREVAIMKRLRHPNIVLFMGAVTQPPNLSIVTEYLSRG 631
Query: 554 SVSSMLNNYGP---FDEPLVKNFTRQILIGLAYLHKRN--IIHRDIKGANILIDIKGGVK 608
S+ +L+ G DE + + G+ YLH RN I+HRD+K N+L+D K VK
Sbjct: 632 SLYRLLHKSGAREQLDERRRLSMAYDVAKGMNYLHNRNPPIVHRDLKSPNLLVDKKYTVK 691
Query: 609 ITDFGISKKLSPLNKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGK 668
+ DFG+S+ L +K A+ G+ WMAPEV++ + EK+D++S G ++ E+ T +
Sbjct: 692 VCDFGLSR-LKASTFLSSKSAA--GTPEWMAPEVLRDEPSNEKSDVYSFGVILWELATLQ 748
Query: 669 HPFPDFSQMQAIFKIGTNIIP-EIPSWVSEEAKAFLFKSFELDYRKRPS 716
P+ + + Q + +G EIP ++ + A + + + KRPS
Sbjct: 749 QPWGNLNPAQVVAAVGFKCKRLEIPRNLNPQVAAIIEGCWTNEPWKRPS 797
>Hs19311016_1 [R] KOG0589 Serine/threonine protein kinase
Length = 330
Score = 111 bits (278), Expect = 3e-24
Identities = 85/286 (29%), Positives = 133/286 (45%), Gaps = 39/286 (13%)
Query: 445 IGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKNT 504
+G G+FG L E L+ K+V+L T
Sbjct: 58 LGRGAFGEATLYRRTEDDSLVVWKEVDL-------------------------------T 86
Query: 505 SQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNYGP 564
++ DAL +E+ IL L H+NI+ YY + L I LEY GG++ +
Sbjct: 87 RLSEKERRDAL-NEIVILALLQHDNIIAYYNHFMDNTTLLIELEYCNGGNLYDKILRQKD 145
Query: 565 --FDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPLN 622
F+E +V + QI+ ++ +HK I+HRDIK NI + +K+ D+G++KKL N
Sbjct: 146 KLFEEEMVVWYLFQIVSAVSCIHKAGILHRDIKTLNIFLTKANLIKLGDYGLAKKL---N 202
Query: 623 KQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAIFK 682
+ + +L G+ Y+M+PE+ + V K+DIW+VGCVI E+ T K F + + K
Sbjct: 203 SEYSMAETLVGTPYYMSPELCQGVKYNFKSDIWAVGCVIFELLTLKRTFDATNPLNLCVK 262
Query: 683 I--GTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
I G + S S E + + D +RP++ LL P L
Sbjct: 263 IVQGIRAMEVDSSQYSLELIQMVHSCLDQDPEQRPTADELLDRPLL 308
>Hs20149547 [T] KOG0603 Ribosomal protein S6 kinase
Length = 735
Score = 111 bits (277), Expect = 4e-24
Identities = 84/276 (30%), Positives = 137/276 (49%), Gaps = 39/276 (14%)
Query: 445 IGSGSFGSVYLGMNA---ETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAV 501
+G GSFG V+L ++G L A+K + KKA +
Sbjct: 68 LGQGSFGKVFLVRKVTRPDSGHLYAMKVL------------------KKA--------TL 101
Query: 502 KNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNN 561
K ++ KM E +IL +++H +V + + Q G L + L+++ GG + + L+
Sbjct: 102 KVRDRVRTKM------ERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSK 155
Query: 562 YGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPL 621
F E VK + ++ +GL +LH II+RD+K NIL+D +G +K+TDFG+SK+
Sbjct: 156 EVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAI-- 213
Query: 622 NKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAIF 681
+ K S G+V +MAPEVV + + AD WS G ++ EM TG PF + + +
Sbjct: 214 -DHEKKAYSFCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMT 272
Query: 682 KIGTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSS 717
I +P ++S EA++ L F+ + R S
Sbjct: 273 LI-LKAKLGMPQFLSTEAQSLLRALFKRNPANRLGS 307
Score = 83.2 bits (204), Expect = 1e-15
Identities = 73/262 (27%), Positives = 121/262 (45%), Gaps = 22/262 (8%)
Query: 478 TAGVVSIADESKKAHSPGGGNTAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSS 537
T GV S ++ + H AVK + R + ++ +L+ H NI+T
Sbjct: 423 TIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEIEI---LLRYGQHPNIITLKDVY 479
Query: 538 QEGGNLNIFLEYVPGGSVSSMLNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGA 597
+G ++ + E + GG + + F E I + YLH + ++HRD+K +
Sbjct: 480 DDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDLKPS 539
Query: 598 NIL-IDIKGG---VKITDFGISKKLSPLNKQQNKRASLQGSVY---WMAPEVVKQVVTTE 650
NIL +D G ++I DFG +K+L N L Y ++APEV+K+ E
Sbjct: 540 NILYVDESGNPECLRICDFGFAKQLRAEN------GLLMTPCYTANFVAPEVLKRQGYDE 593
Query: 651 KADIWSVGCVIVEMFTGKHPF---PDFSQMQAIFKIGT-NIIPEIPSW--VSEEAKAFLF 704
DIWS+G ++ M G PF P + + + +IG+ +W VSE AK +
Sbjct: 594 GCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVS 653
Query: 705 KSFELDYRKRPSSLGLLQEPWL 726
K +D +R ++ +LQ PW+
Sbjct: 654 KMLHVDPHQRLTAKQVLQHPWV 675
>CE15475 [T] KOG0616 cAMP-dependent protein kinase catalytic subunit (PKA)
Length = 375
Score = 111 bits (277), Expect = 4e-24
Identities = 79/274 (28%), Positives = 131/274 (46%), Gaps = 38/274 (13%)
Query: 445 IGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKNT 504
+G+GSFG V L + ++G A+K I D+ K
Sbjct: 58 LGTGSFGRVMLVKHKQSGNYYAMK---------------ILDKQKV-------------- 88
Query: 505 SQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNYGP 564
+ K ++ +E IL+ + +V S ++ NL + LE++ GG + S L G
Sbjct: 89 --VKLKQVEHTLNEKRILQAIDFPFLVNMTFSFKDNSNLYMVLEFISGGEMFSHLRRIGR 146
Query: 565 FDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPLNKQ 624
F EP + + QI++ YLH ++I+RD+K N+LID G +KITDFG +K++
Sbjct: 147 FSEPHSRFYAAQIVLAFEYLHSLDLIYRDLKPENLLIDSTGYLKITDFGFAKRV------ 200
Query: 625 QNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAIFKIG 684
+ + +L G+ ++APE++ + D W++G +I EM G PF +Q KI
Sbjct: 201 KGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIV 260
Query: 685 TNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSL 718
+ + + PS S E K L ++D KR +L
Sbjct: 261 SGKV-KFPSHFSNELKDLLKNLLQVDLTKRYGNL 293
>CE15473 [T] KOG0616 cAMP-dependent protein kinase catalytic subunit (PKA)
Length = 359
Score = 111 bits (277), Expect = 4e-24
Identities = 79/274 (28%), Positives = 131/274 (46%), Gaps = 38/274 (13%)
Query: 445 IGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKNT 504
+G+GSFG V L + ++G A+K I D+ K
Sbjct: 58 LGTGSFGRVMLVKHKQSGNYYAMK---------------ILDKQKV-------------- 88
Query: 505 SQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNYGP 564
+ K ++ +E IL+ + +V S ++ NL + LE++ GG + S L G
Sbjct: 89 --VKLKQVEHTLNEKRILQAIDFPFLVNMTFSFKDNSNLYMVLEFISGGEMFSHLRRIGR 146
Query: 565 FDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPLNKQ 624
F EP + + QI++ YLH ++I+RD+K N+LID G +KITDFG +K++
Sbjct: 147 FSEPHSRFYAAQIVLAFEYLHSLDLIYRDLKPENLLIDSTGYLKITDFGFAKRV------ 200
Query: 625 QNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAIFKIG 684
+ + +L G+ ++APE++ + D W++G +I EM G PF +Q KI
Sbjct: 201 KGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIV 260
Query: 685 TNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSL 718
+ + + PS S E K L ++D KR +L
Sbjct: 261 SGKV-KFPSHFSNELKDLLKNLLQVDLTKRYGNL 293
>At4g18700 [T] KOG0583 Serine/threonine protein kinase
Length = 489
Score = 111 bits (277), Expect = 4e-24
Identities = 80/304 (26%), Positives = 141/304 (46%), Gaps = 40/304 (13%)
Query: 428 SLPTKVEAPKSWL-----KGARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVV 482
SLP + +P++ + G +G G+F VYL N +T E +A+K ++ K + G++
Sbjct: 10 SLPKERSSPQALILGRYEMGKLLGHGTFAKVYLARNVKTNESVAIKVID-KEKVLKGGLI 68
Query: 483 SIADESKKAHSPGGGNTAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGN 542
AH ++ E++IL+ + H NIV +
Sbjct: 69 --------AH----------------------IKREISILRRVRHPNIVQLFEVMATKAK 98
Query: 543 LNIFLEYVPGGSVSSMLNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILID 602
+ +EYV GG + + + G E + + + +Q++ + + H R + HRD+K N+L+D
Sbjct: 99 IYFVMEYVRGGELFNKVAK-GRLKEEVARKYFQQLISAVTFCHARGVYHRDLKPENLLLD 157
Query: 603 IKGGVKITDFGISKKLSPLNKQQNKRASLQGSVYWMAPEVV-KQVVTTEKADIWSVGCVI 661
G +K++DFG+S +S +Q + G+ ++APEV+ ++ K DIWS G ++
Sbjct: 158 ENGNLKVSDFGLS-AVSDQIRQDGLFHTFCGTPAYVAPEVLARKGYDAAKVDIWSCGVIL 216
Query: 662 VEMFTGKHPFPDFSQMQAIFKIGTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLL 721
+ G PF D + M KI P W S E L K E + KR + ++
Sbjct: 217 FVLMAGYLPFHDRNVMAMYKKIYRGEF-RCPRWFSTELTRLLSKLLETNPEKRFTFPEIM 275
Query: 722 QEPW 725
+ W
Sbjct: 276 ENSW 279
>At3g50310 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 342
Score = 111 bits (277), Expect = 4e-24
Identities = 87/307 (28%), Positives = 136/307 (43%), Gaps = 60/307 (19%)
Query: 439 WLKGARIGSGSFGSVYLGMNAETG----ELMAVKQVELKPTAVTAGVVSIADESKKAHSP 494
W++G IG G+F +V + L+AVK + G S+++E S
Sbjct: 3 WVRGETIGFGTFSTVSTATKSRNSGDFPALIAVKSTD------AYGAASLSNEKSVLDSL 56
Query: 495 G---------GGNTAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNI 545
G G ++ V+N ++H N+
Sbjct: 57 GDCPEIIRCYGEDSTVENGEEMH-----------------------------------NL 81
Query: 546 FLEYVPGGSVSSMLNNYGP--FDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDI 603
LEY GS++S + G E V+ T +L GL ++H + H DIK ANIL+
Sbjct: 82 LLEYASRGSLASYMKKLGGEGLPESTVRRHTGSVLRGLRHIHAKGFAHCDIKLANILLFN 141
Query: 604 KGGVKITDFGISKKLSPLNKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVE 663
G VKI DFG++ ++ K ++G+ +MAPE V AD+W++GC +VE
Sbjct: 142 DGSVKIADFGLAMRVDGDLTALRKSVEIRGTPLYMAPECVNDNEYGSAADVWALGCAVVE 201
Query: 664 MFTGKHPF---PDFSQMQAIFKIGT-NIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLG 719
MF+GK + M + +IG + +P+IP +SEE K FL K F D KR ++
Sbjct: 202 MFSGKTAWSVKEGSHFMSLLIRIGVGDELPKIPEMLSEEGKDFLSKCFVKDPAKRWTAEM 261
Query: 720 LLQEPWL 726
LL ++
Sbjct: 262 LLNHSFV 268
>At3g23000 [T] KOG0583 Serine/threonine protein kinase
Length = 429
Score = 111 bits (277), Expect = 4e-24
Identities = 81/303 (26%), Positives = 141/303 (45%), Gaps = 37/303 (12%)
Query: 430 PTKVEAPKSWLKGARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESK 489
P K+ K L G R+GSGSF V+L + E+ EL+AVK +E K T
Sbjct: 17 PAKILLGKYEL-GRRLGSGSFAKVHLARSIESDELVAVKIIEKKKT-------------- 61
Query: 490 KAHSPGGGNTAVKNTSQIHRKMIDALQHEMNILKEL-HHENIVTYYGSSQEGGNLNIFLE 548
I M + E++ ++ L HH NI+ + + + +E
Sbjct: 62 -----------------IESGMEPRIIREIDAMRRLRHHPNILKIHEVMATKSKIYLVME 104
Query: 549 YVPGGSVSSMLNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVK 608
GG + S + G E + + +Q+ L + H+ + HRD+K N+L+D +G +K
Sbjct: 105 LASGGELFSKVLRRGRLPESTARRYFQQLASALRFSHQDGVAHRDVKPQNLLLDEQGNLK 164
Query: 609 ITDFGISKKLSPLNKQQNKRASLQGSVYWMAPEVV-KQVVTTEKADIWSVGCVIVEMFTG 667
++DFG+S P + Q + G+ + APEV+ ++ KAD WS G ++ + G
Sbjct: 165 VSDFGLS--ALPEHLQNGLLHTACGTPAYTAPEVISRRGYDGAKADAWSCGVILFVLLVG 222
Query: 668 KHPFPDFSQMQAIFKIGTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWLN 727
PF D S + A+++ PSW+S++AK+ +++ + + R S +++ W
Sbjct: 223 DVPFDD-SNIAAMYRKIHRRDYRFPSWISKQAKSIIYQMLDPNPVTRMSIETVMKTNWFK 281
Query: 728 TVL 730
L
Sbjct: 282 KSL 284
>SPAC19E9.02 [D] KOG0591 NIMA (never in mitosis)-related G2-specific
serine/threonine protein kinase
Length = 722
Score = 110 bits (276), Expect = 6e-24
Identities = 86/313 (27%), Positives = 140/313 (44%), Gaps = 66/313 (21%)
Query: 445 IGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKNT 504
IG GSFG +Y + G L+A K++ GN
Sbjct: 10 IGHGSFGRIYKVQRLKDGALLAQKEIHF------------------------GN------ 39
Query: 505 SQIHRKMIDALQHEMNILKELHHENIVTYYGS--SQEGGNLNIFLEYVPGGSVSSMLNNY 562
I R+ + E+NIL+ L H NIV Y G ++ +N+++EY G +++++ Y
Sbjct: 40 --ITRQEKQYIADEVNILRNLKHPNIVQYCGEELNRSAQVINLYMEYCGHGDLANLIQRY 97
Query: 563 GP----FDEPLVKNFTRQILIGLAYLH-------------------KRNIIHRDIKGANI 599
F E V F Q+L+ L H K++++HRDIK ANI
Sbjct: 98 KEEKKRFTEQEVLKFFTQLLLALYRCHYGENAPACDSQWPREIFHPKQSVLHRDIKPANI 157
Query: 600 LIDIKGGVKITDFGISKKLSPLNKQQNKRASLQ---GSVYWMAPEVVKQVVTTEKADIWS 656
+D VK+ DFG+SK L N R Q G+ Y+M+PE+++ + K+D+W+
Sbjct: 158 FLDENNSVKLGDFGLSKLLD------NTRVFTQSYVGTPYYMSPEIIRSSPYSAKSDVWA 211
Query: 657 VGCVIVEMFTGKHPFPDFSQMQAIFKIGTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPS 716
+GCVI E+ HPF S ++ I + S++ + E++ RP+
Sbjct: 212 LGCVIFEICMLTHPFEGRSYLELQRNICQGNLSCWDHHYSDDVFLLIRHCLEVNSDLRPT 271
Query: 717 SLGLLQEPWLNTV 729
+ LL+ P L+ +
Sbjct: 272 TYQLLRSPILSDI 284
>CE15235 [R] KOG0589 Serine/threonine protein kinase
Length = 357
Score = 110 bits (276), Expect = 6e-24
Identities = 68/232 (29%), Positives = 124/232 (53%), Gaps = 14/232 (6%)
Query: 503 NTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNY 562
NT + K +++Q E+N+LK++ H I+ Y S L I ++Y GG++ ++N+
Sbjct: 38 NTHGMTEKEENSIQSEVNLLKKVQHPLIIGYIDSFIMDNQLGIVMQYAEGGTLERLINDQ 97
Query: 563 GP---------FDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGV-KITDF 612
F E V ++ QILI L ++H++NI+HRD+K NIL++ + V K++DF
Sbjct: 98 RAIKDSNMREYFPEKTVLDYFTQILIALNHMHQKNIVHRDLKPQNILMNRRKTVLKLSDF 157
Query: 613 GISKKLSPLNKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFP 672
GISK+L ++ +++ G+ +++PE+ + +K+D+WS+GCV+ E+ + F
Sbjct: 158 GISKELG----TKSAASTVIGTPNYLSPEICESRPYNQKSDMWSLGCVLYELLQLERAFD 213
Query: 673 DFSQMQAIFKIGTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEP 724
+ + KI + + VS + K + + KRP LL +P
Sbjct: 214 GENLPAIVMKITRSKQNPLGDHVSNDVKMLVENLLKTHTDKRPDVSQLLSDP 265
>7297542 [T] KOG0616 cAMP-dependent protein kinase catalytic subunit (PKA)
Length = 353
Score = 110 bits (276), Expect = 6e-24
Identities = 79/289 (27%), Positives = 135/289 (46%), Gaps = 38/289 (13%)
Query: 430 PTKVEAPKSWLKGARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESK 489
PT A + + +G+GSFG V + + T + A+K I D+ K
Sbjct: 37 PTNTAALDDFERIKTLGTGSFGRVMIVQHKPTKDYYAMK---------------ILDKQK 81
Query: 490 KAHSPGGGNTAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEY 549
+ K ++ +E IL+ + +V+ ++ NL + LEY
Sbjct: 82 V----------------VKLKQVEHTLNEKRILQAIQFPFLVSLRYHFKDNSNLYMVLEY 125
Query: 550 VPGGSVSSMLNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKI 609
VPGG + S L G F EP + + QI++ YLH ++I+RD+K N+LID +G +K+
Sbjct: 126 VPGGEMFSHLRKVGRFSEPHSRFYAAQIVLAFEYLHYLDLIYRDLKPENLLIDSQGYLKV 185
Query: 610 TDFGISKKLSPLNKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKH 669
TDFG +K++ + + +L G+ ++APE++ + D W++G ++ EM G
Sbjct: 186 TDFGFAKRV------KGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLVYEMAAGYP 239
Query: 670 PFPDFSQMQAIFKIGTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSL 718
PF +Q KI + + PS + K L ++D KR +L
Sbjct: 240 PFFADQPIQIYEKIVSGKV-RFPSHFGSDLKDLLRNLLQVDLTKRYGNL 287
>YCL024w [T] KOG0583 Serine/threonine protein kinase
Length = 1037
Score = 110 bits (275), Expect = 8e-24
Identities = 84/293 (28%), Positives = 137/293 (46%), Gaps = 33/293 (11%)
Query: 439 WLKGARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGN 498
W G +G GS G V L + TG AVK + SK + G
Sbjct: 21 WKLGETLGFGSTGKVQLAQHERTGHRTAVKVI-----------------SKSIFNNNG-- 61
Query: 499 TAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSM 558
N S + ++ E+ I+K L H N+++ Y + NL + LEY G + ++
Sbjct: 62 ----NHSNDDSVLPYNIEREIVIMKLLSHPNVLSLYDVWETNNNLYLILEYAEKGELFNL 117
Query: 559 LNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKL 618
L ++GP E N RQI+IG++Y H I+HRD+K N+L+D +KI DFG +
Sbjct: 118 LVDHGPLPEREAINCFRQIIIGISYCHALGIVHRDLKPENLLLDSFYNIKIADFG----M 173
Query: 619 SPLNKQQNKRASLQGSVYWMAPEVVKQVVTTEKA-DIWSVGCVIVEMFTGKHPFPD--FS 675
+ L + + GS ++ APE+V + A D+WS G ++ + TG+ PF + +
Sbjct: 174 AALQTDADLLETSCGSPHYAAPEIVSGLPYEGFASDVWSCGVILFALLTGRLPFDEENGN 233
Query: 676 QMQAIFKIGTNIIPEIP--SWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
+ K+ E+P + +S +A+ + K +D R+R +L P L
Sbjct: 234 VRDLLLKVQKGQF-EMPNDTEISRDAQDLIGKILVVDPRQRIKIRDILSHPLL 285
>At5g58950 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 561
Score = 110 bits (275), Expect = 8e-24
Identities = 69/201 (34%), Positives = 107/201 (52%), Gaps = 7/201 (3%)
Query: 518 EMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNYGPFDEPLVK--NFTR 575
E+ +L L H N++ + G+ ++ + +Y+P GS+ S L+ PL K F
Sbjct: 294 EVTLLSRLTHPNVIKFVGAYKDPPVYCVLTQYLPEGSLRSFLHKPENRSLPLKKLIEFAI 353
Query: 576 QILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPLNKQQNKRASLQGSV 635
I G+ Y+H R IIHRD+K N+LID + +KI DFGI+ + + + A G+
Sbjct: 354 DIARGMEYIHSRRIIHRDLKPENVLIDEEFHLKIADFGIACE----EEYCDMLADDPGTY 409
Query: 636 YWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAIFK-IGTNIIPEIPSW 694
WMAPE++K+ KAD++S G V+ EM G P+ D + +QA F + NI P IP
Sbjct: 410 RWMAPEMIKRKPHGRKADVYSFGLVLWEMVAGAIPYEDMNPIQAAFAVVHKNIRPAIPGD 469
Query: 695 VSEEAKAFLFKSFELDYRKRP 715
KA + + + + KRP
Sbjct: 470 CPVAMKALIEQCWSVAPDKRP 490
>At5g39420 [D] KOG0600 Cdc2-related protein kinase
Length = 576
Score = 110 bits (275), Expect = 8e-24
Identities = 74/258 (28%), Positives = 130/258 (49%), Gaps = 40/258 (15%)
Query: 429 LPTKVEAPKSWLKGARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADES 488
+P K EA + K +IG G++ SV+ ETG+++A+K+V+
Sbjct: 98 VPLKAEA---FQKLEKIGQGTYSSVFRAREVETGKMVALKKVKF---------------- 138
Query: 489 KKAHSPGGGNTAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYG--SSQEGGNLNIF 546
+ + I + E+ IL++L+H NI+ G +S+ ++ +
Sbjct: 139 ----------------DNLQPESIRFMAREILILRKLNHPNIMKLEGIVTSRASSSIYLV 182
Query: 547 LEYVPGGSVSSMLNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGG 606
EY+ N F EP +K + +Q+L GL + H R +IHRDIK +NIL++ KG
Sbjct: 183 FEYMEHDLAGLSSNPDIRFTEPQIKCYMKQLLWGLEHCHMRGVIHRDIKASNILVNNKGV 242
Query: 607 VKITDFGISKKLSPLNKQQNKRASLQGSVYWMAPEVVKQVVT-TEKADIWSVGCVIVEMF 665
+K+ DFG++ ++P NK N+ S ++++ APE++ + D+WSVGCV E+
Sbjct: 243 LKLGDFGLANVVTPSNK--NQLTSRVVTLWYRAPELLMGSTSYGVSVDLWSVGCVFAEIL 300
Query: 666 TGKHPFPDFSQMQAIFKI 683
GK ++++ + KI
Sbjct: 301 MGKPILKGRTEIEQLHKI 318
>At5g35410 [T] KOG0583 Serine/threonine protein kinase
Length = 446
Score = 110 bits (275), Expect = 8e-24
Identities = 74/285 (25%), Positives = 135/285 (46%), Gaps = 36/285 (12%)
Query: 442 GARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAV 501
G IG G+F V N +TG+ +A+K + +T +
Sbjct: 14 GRTIGEGTFAKVKFARNTDTGDNVAIKIM-------------------------AKSTIL 48
Query: 502 KNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNN 561
KN +M+D ++ E++I+K + H NIV Y + I LE+V GG + + +
Sbjct: 49 KN------RMVDQIKREISIMKIVRHPNIVRLYEVLASPSKIYIVLEFVTGGELFDRIVH 102
Query: 562 YGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPL 621
G +E + + +Q++ +A+ H + + HRD+K N+L+D G +K++DFG+S P
Sbjct: 103 KGRLEESESRKYFQQLVDAVAHCHCKGVYHRDLKPENLLLDTNGNLKVSDFGLS--ALPQ 160
Query: 622 NKQQNKRASLQGSVYWMAPEVVK-QVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAI 680
+ R + G+ ++APEV+ Q ADIWS G ++ + G PF + + + +
Sbjct: 161 EGVELLRTTC-GTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSE-TDLPGL 218
Query: 681 FKIGTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPW 725
++ P W S E K + + + + + R G+ ++PW
Sbjct: 219 YRKINAAEFSCPPWFSAEVKFLIHRILDPNPKTRIQIQGIKKDPW 263
>At4g14580 [T] KOG0583 Serine/threonine protein kinase
Length = 426
Score = 110 bits (275), Expect = 8e-24
Identities = 77/294 (26%), Positives = 134/294 (45%), Gaps = 41/294 (13%)
Query: 442 GARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAV 501
G R+GSGSF V++ + TGEL+A+K ++ + T
Sbjct: 24 GRRLGSGSFAKVHVARSISTGELVAIKIIDKQKT-------------------------- 57
Query: 502 KNTSQIHRKMIDALQHEMNILKELH-HENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLN 560
I M + E+ ++ LH H N++ + + + +EY GG + + L
Sbjct: 58 -----IDSGMEPRIIREIEAMRRLHNHPNVLKIHEVMATKSKIYLVVEYAAGGELFTKLI 112
Query: 561 NYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSP 620
+G +E + + +Q+ L++ H+ I HRD+K N+L+D +G +K++DFG LS
Sbjct: 113 RFGRLNESAARRYFQQLASALSFCHRDGIAHRDVKPQNLLLDKQGNLKVSDFG----LSA 168
Query: 621 LNKQQNKRASLQ---GSVYWMAPEVVKQ-VVTTEKADIWSVGCVIVEMFTGKHPFPDFSQ 676
L + ++ L G+ + APEV+ Q KAD WS G + + G PF D +
Sbjct: 169 LPEHRSNNGLLHTACGTPAYTAPEVIAQRGYDGAKADAWSCGVFLFVLLAGYVPFDDANI 228
Query: 677 MQAIFKIGTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWLNTVL 730
+ KI PSW+S+ A++ ++K + + R S ++ W L
Sbjct: 229 VAMYRKIHKRDY-RFPSWISKPARSIIYKLLDPNPETRMSIEAVMGTVWFQKSL 281
>Hs4506057 [T] KOG0616 cAMP-dependent protein kinase catalytic subunit (PKA)
Length = 351
Score = 110 bits (274), Expect = 1e-23
Identities = 78/274 (28%), Positives = 132/274 (47%), Gaps = 38/274 (13%)
Query: 445 IGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKNT 504
+G+GSFG V L + T + A+K I D+ K
Sbjct: 50 LGTGSFGRVMLVKHKATEQYYAMK---------------ILDKQK--------------- 79
Query: 505 SQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNYGP 564
+ K I+ +E IL+ ++ +V + ++ NL + +EYVPGG + S L G
Sbjct: 80 -VVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGR 138
Query: 565 FDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPLNKQ 624
F EP + + QI++ YLH ++I+RD+K N+LID +G +++TDFG +K++
Sbjct: 139 FSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRV------ 192
Query: 625 QNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAIFKIG 684
+ + +L G+ ++APE++ + D W++G +I EM G PF +Q KI
Sbjct: 193 KGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIV 252
Query: 685 TNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSL 718
+ + PS S + K L ++D KR +L
Sbjct: 253 SGKV-RFPSHFSSDLKDLLRNLLQVDLTKRFGNL 285
>Hs4502803 [D] KOG0590 Checkpoint kinase and related serine/threonine protein
kinases
Length = 476
Score = 110 bits (274), Expect = 1e-23
Identities = 72/236 (30%), Positives = 115/236 (48%), Gaps = 35/236 (14%)
Query: 437 KSWLKGARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGG 496
+ W +G G++G V L +N T E +AVK V++K V + KK
Sbjct: 7 EDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRA------VDCPENIKK------ 54
Query: 497 GNTAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVS 556
E+ I K L+HEN+V +YG +EG +FLEY GG +
Sbjct: 55 ---------------------EICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELF 93
Query: 557 SMLNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISK 616
+ EP + F Q++ G+ YLH I HRDIK N+L+D + +KI+DFG++
Sbjct: 94 DRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLA- 152
Query: 617 KLSPLNKQQNKRASLQGSVYWMAPEVVK-QVVTTEKADIWSVGCVIVEMFTGKHPF 671
+ N ++ + G++ ++APE++K + E D+WS G V+ M G+ P+
Sbjct: 153 TVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPW 208
>CE28218 [D] KOG0588 Serine/threonine protein kinase
Length = 914
Score = 110 bits (274), Expect = 1e-23
Identities = 65/239 (27%), Positives = 118/239 (49%), Gaps = 8/239 (3%)
Query: 492 HSPGGGNTAVK--NTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEY 549
H G A+K N ++ ++ ++ E+ I+K + H +++ Y + L + LE+
Sbjct: 66 HCITGRKVAIKIVNKEKLSESVLQKVEREIAIMKLIEHPHVLHLYDVYENKKYLYLLLEH 125
Query: 550 VPGGSVSSMLNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKI 609
V GG + L G + F RQI+ L + H NI HRD+K N+L+D + +K+
Sbjct: 126 VSGGELFDYLVRKGRLMSKEARKFFRQIISALDFCHAHNICHRDLKPENLLLDERNNIKV 185
Query: 610 TDFGISKKLSPLNKQQNKRASLQGSVYWMAPEVVK-QVVTTEKADIWSVGCVIVEMFTGK 668
DFG ++ L + + + GS ++ PEV++ + KAD+WS G ++ + G
Sbjct: 186 ADFG----MASLQVEGSMLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVILYALLVGA 241
Query: 669 HPFPDFSQMQAIFKIGTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWLN 727
PF D + + K+ + IP +V + ++ L E+D KR S + + PW++
Sbjct: 242 LPFDDDNLRNLLEKVKRGVF-HIPHFVPADVQSLLRAMIEVDPGKRYSLADVFKHPWVS 299
>Hs4505695 [T] KOG0592 3-phosphoinositide-dependent protein kinase (PDK1)
Length = 556
Score = 109 bits (273), Expect = 1e-23
Identities = 76/279 (27%), Positives = 129/279 (45%), Gaps = 33/279 (11%)
Query: 436 PKSWLKGARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPG 495
P+ + G +G GSF +V L T A+K +E + I E+K
Sbjct: 79 PEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKR---------HIIKENK------ 123
Query: 496 GGNTAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSV 555
+ + E +++ L H V Y + Q+ L L Y G +
Sbjct: 124 ----------------VPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGEL 167
Query: 556 SSMLNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGIS 615
+ G FDE + +T +I+ L YLH + IIHRD+K NIL++ ++ITDFG +
Sbjct: 168 LKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTA 227
Query: 616 KKLSPLNKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFS 675
K LSP +KQ + S G+ +++PE++ + + +D+W++GC+I ++ G PF +
Sbjct: 228 KVLSPESKQA-RANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGN 286
Query: 676 QMQAIFKIGTNIIPEIPSWVSEEAKAFLFKSFELDYRKR 714
+ IF+ + + P +A+ + K LD KR
Sbjct: 287 E-YLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKR 324
>Hs18552621 [R] KOG0597 Serine-threonine protein kinase FUSED
Length = 1315
Score = 109 bits (273), Expect = 1e-23
Identities = 83/282 (29%), Positives = 131/282 (46%), Gaps = 37/282 (13%)
Query: 445 IGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKNT 504
IG GSFG VY G + +++A+K + P G +
Sbjct: 10 IGEGSFGRVYKGRRKYSAQVVALKFI-----------------------PKLGRS----- 41
Query: 505 SQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNYGP 564
K + LQ E+ I++ L H NIV S + + + +Y G + +L + G
Sbjct: 42 ----EKELRNLQREIEIMRGLRHPNIVHMLDSFETDKEVVVVTDYAEG-ELFQILEDDGK 96
Query: 565 FDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPLNKQ 624
E V+ Q++ L YLH I+HRD+K NIL+ GG+K+ DFG ++ +S
Sbjct: 97 LPEDQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMS---TN 153
Query: 625 QNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAIFKIG 684
S++G+ +M+PE+V++ AD+WSVGC++ E+ G PF S Q + I
Sbjct: 154 TMVLTSIKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYATSIFQLVSLIL 213
Query: 685 TNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
+ + PS +S K FL D R+R S LL P++
Sbjct: 214 KDPV-RWPSTISPCFKNFLQGLLTKDPRQRLSWPDLLYHPFI 254
>At1g73660 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 1030
Score = 109 bits (273), Expect = 1e-23
Identities = 74/241 (30%), Positives = 120/241 (49%), Gaps = 15/241 (6%)
Query: 496 GGNTAVKN--TSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGG 553
G AVK + + ++ + E+ I+K+L H NIV + G+ NL+I E++P G
Sbjct: 769 GTEVAVKKFLDQDLTGEALEEFRSEVRIMKKLRHPNIVLFMGAVTRPPNLSIVTEFLPRG 828
Query: 554 SVSSMLNN-YGPFDEPLVKNFTRQILIGLAYLHKRN--IIHRDIKGANILIDIKGGVKIT 610
S+ +++ DE G+ YLH N I+HRD+K N+L+D VK+
Sbjct: 829 SLYRLIHRPNNQLDERRRLRMALDAARGMNYLHSCNPMIVHRDLKSPNLLVDKNWVVKVC 888
Query: 611 DFGISKKLSPLNKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHP 670
DFG+S+ A G+ WMAPEV++ EK D++S G ++ E+FT + P
Sbjct: 889 DFGLSRMKHSTYLSSKSTA---GTAEWMAPEVLRNEPADEKCDVYSYGVILWELFTLQQP 945
Query: 671 FPDFSQMQAIFKIG-TNIIPEIPSWVSEEAKAFLFKSFELDYRKRPS------SLGLLQE 723
+ + MQ + +G + +IP +V + K ++ D + RPS SL LQ+
Sbjct: 946 WGKMNPMQVVGAVGFQHRRLDIPDFVDPAIADLISKCWQTDSKLRPSFAEIMASLKRLQK 1005
Query: 724 P 724
P
Sbjct: 1006 P 1006
>YDR466w [T] KOG0592 3-phosphoinositide-dependent protein kinase (PDK1)
Length = 898
Score = 109 bits (272), Expect = 2e-23
Identities = 69/270 (25%), Positives = 128/270 (46%), Gaps = 43/270 (15%)
Query: 429 LPTKVEAPKSWLKGARIGSGSFGSVYLGMNAET-GELMAVKQVELKPTAVTAGVVSIADE 487
+ ++ +P ++ +G GS+ +V+ ++ ++ ++ A+K K A V + E
Sbjct: 1 MTSRKRSPHDFIFKEELGHGSYSTVFKALDKKSPNKIYAIKVCSKKHIIKEAKVKYVTIE 60
Query: 488 SKKAHSPGGGNTAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFL 547
KNT MN+L + HH I+ Y + + NL L
Sbjct: 61 --------------KNT--------------MNLLAQKHHAGIIKLYYTFHDEENLYFVL 92
Query: 548 EYVPGGSVSSMLNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGV 607
++ PGG + S+L+ G F++ ++FT Q++ L ++H IIHRD+K N+L+D G +
Sbjct: 93 DFAPGGELLSLLHKMGTFNDIWTRHFTAQLIDALEFIHSHGIIHRDLKPENVLLDRDGRL 152
Query: 608 KITDFGISKKLSPL--------------NKQQNKRASLQGSVYWMAPEVVKQVVTTEKAD 653
ITDFG + + P +K AS G+ +++PE++ +D
Sbjct: 153 MITDFGAAATIDPSLSGDSAKFNSDSNGSKDNQNCASFVGTAEYVSPELLLYNQCGYGSD 212
Query: 654 IWSVGCVIVEMFTGKHPFPDFSQMQAIFKI 683
IW++GC+I + G+ PF ++++ KI
Sbjct: 213 IWALGCMIYQFVQGQPPFRGENELKTFEKI 242
>At1g33770 [D] KOG0600 Cdc2-related protein kinase
Length = 614
Score = 109 bits (272), Expect = 2e-23
Identities = 78/266 (29%), Positives = 130/266 (48%), Gaps = 52/266 (19%)
Query: 434 EAPKSWL--------KGARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIA 485
EA K W+ K +IG G++ VY + ETG+++A+K+V
Sbjct: 128 EAIKGWVPRRADSFEKLDKIGQGTYSIVYKARDLETGKIVAMKKVRF------------- 174
Query: 486 DESKKAHSPGGGNTAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYG--SSQEGGNL 543
+ + + + + E+NIL++L H N++ +S+ G+L
Sbjct: 175 -------------------ANMDPESVRFMAREINILRKLDHPNVMKLQCLVTSKLSGSL 215
Query: 544 NIFLEYVPGGSVSSMLNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDI 603
++ EY+ L F EP +K F +Q+L GL + H R I+HRDIKG+N+L++
Sbjct: 216 HLVFEYMEHDLSGLALRPGVKFTEPQIKCFMKQLLCGLEHCHSRGILHRDIKGSNLLVNN 275
Query: 604 KGGVKITDFGISKKLSPLNKQQNKRASLQGSVYWMAPEVVKQVVTTE---KADIWSVGCV 660
G +KI DFG++ P Q S ++++ APE++ + +TE D+WSVGC+
Sbjct: 276 DGVLKIGDFGLASFYKP--DQDQPLTSRVVTLWYRAPELL--LGSTEYGPAIDLWSVGCI 331
Query: 661 IVEMFTGKHPFP---DFSQMQAIFKI 683
+ E+F K P + QM IFK+
Sbjct: 332 LAELFVCKPIMPGRTEVEQMHKIFKL 357
>Hs7019543 [T] KOG0582 Ste20-like serine/threonine protein kinase
Length = 547
Score = 108 bits (271), Expect = 2e-23
Identities = 73/231 (31%), Positives = 121/231 (51%), Gaps = 20/231 (8%)
Query: 512 IDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSML--------NNYG 563
+D L E+ + + H N+VTYY S L + ++ + GGS+ ++ + G
Sbjct: 105 MDELLKEIQAMSQCSHPNVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNG 164
Query: 564 PFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSP-LN 622
+E ++ +++L GL YLH+ IHRD+K NIL+ G V+I DFG+S L+ +
Sbjct: 165 VLEEAIIATILKEVLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGD 224
Query: 623 KQQNK-RASLQGSVYWMAPEVVKQVVTTE-KADIWSVGCVIVEMFTGKHPFPDFSQMQAI 680
+NK R + G+ WMAPEV++QV + KAD+WS G +E+ TG P+ + M+ +
Sbjct: 225 VTRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVL 284
Query: 681 FKIGTNIIPEIPSWVSEE------AKAF---LFKSFELDYRKRPSSLGLLQ 722
N P + + V ++ K+F L + D KRP++ LL+
Sbjct: 285 MLTLQNDPPTLETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLK 335
>Hs4759050 [T] KOG0603 Ribosomal protein S6 kinase
Length = 740
Score = 108 bits (271), Expect = 2e-23
Identities = 83/267 (31%), Positives = 134/267 (50%), Gaps = 39/267 (14%)
Query: 445 IGSGSFGSVYLGMN---AETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAV 501
+G GSFG V+L ++ +L A+K + KKA +
Sbjct: 74 LGQGSFGKVFLVKKISGSDARQLYAMKVL------------------KKA--------TL 107
Query: 502 KNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNN 561
K ++ KM E +IL E++H IV + + Q G L + L+++ GG + + L+
Sbjct: 108 KVRDRVRTKM------ERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSK 161
Query: 562 YGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPL 621
F E VK + ++ + L +LH II+RD+K NIL+D +G +K+TDFG+SK+
Sbjct: 162 EVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESI-- 219
Query: 622 NKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAIF 681
+ K S G+V +MAPEVV + T+ AD WS G ++ EM TG PF + + +
Sbjct: 220 -DHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMT 278
Query: 682 KIGTNIIPEIPSWVSEEAKAFLFKSFE 708
I +P ++S EA++ L F+
Sbjct: 279 MI-LKAKLGMPQFLSPEAQSLLRMLFK 304
Score = 80.5 bits (197), Expect = 8e-15
Identities = 62/219 (28%), Positives = 104/219 (47%), Gaps = 19/219 (8%)
Query: 521 ILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNYGPFDEPLVKNFTRQILIG 580
+L+ H NI+T +G + + E + GG + + F E I
Sbjct: 467 LLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKT 526
Query: 581 LAYLHKRNIIHRDIKGANIL-IDIKG---GVKITDFGISKKLSPLNKQQNKRASLQGSVY 636
+ YLH + ++HRD+K +NIL +D G ++I DFG +K+L N L Y
Sbjct: 527 VEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAEN------GLLMTPCY 580
Query: 637 ---WMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPF---PDFSQMQAIFKIGTNIIPE 690
++APEV+K+ DIWS+G ++ M TG PF PD + + + +IG+
Sbjct: 581 TANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSL 640
Query: 691 IPSW---VSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
+ VS+ AK + K +D +R ++ +L+ PW+
Sbjct: 641 SGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWI 679
>At4g23050 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 736
Score = 108 bits (271), Expect = 2e-23
Identities = 73/252 (28%), Positives = 128/252 (49%), Gaps = 17/252 (6%)
Query: 476 AVTAGVVSIADESKKAHSPGGGNTAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYG 535
AV GV + +D + K + G N + + E+NI+K+L H N++ + G
Sbjct: 481 AVHRGVWNGSDVAIKVYFDGDYNAMT----------LTECKKEINIMKKLRHPNVLLFMG 530
Query: 536 SSQEGGNLNIFLEYVPGGSVSSMLNNYG-PFDEPLVKNFTRQILIGLAYLHKRN--IIHR 592
+ I +EY+P GS+ +L+N P D+ + G+ YLH+RN I+HR
Sbjct: 531 AVCTEEKSAIIMEYMPRGSLFKILHNTNQPLDKKRRLRMALDVARGMNYLHRRNPPIVHR 590
Query: 593 DIKGANILIDIKGGVKITDFGISKKLSPLNKQQNKRASLQGSVYWMAPEVVKQVVTTEKA 652
D+K +N+L+D VK+ DFG+SK N S +G+ WMAPEV++ + EK
Sbjct: 591 DLKSSNLLVDKNWNVKVGDFGLSKWK---NATFLSTKSGKGTPQWMAPEVLRSEPSNEKC 647
Query: 653 DIWSVGCVIVEMFTGKHPFPDFSQMQAIFKIG-TNIIPEIPSWVSEEAKAFLFKSFELDY 711
D++S G ++ E+ T P+ + +Q + +G + ++P ++ + + ++ D
Sbjct: 648 DVFSFGVILWELMTTLVPWDRLNSIQVVGVVGFMDRRLDLPEGLNPRIASIIQDCWQTDP 707
Query: 712 RKRPSSLGLLQE 723
KRPS L+ +
Sbjct: 708 AKRPSFEELISQ 719
>At3g04810 [R] KOG0589 Serine/threonine protein kinase
Length = 606
Score = 108 bits (271), Expect = 2e-23
Identities = 78/286 (27%), Positives = 133/286 (46%), Gaps = 39/286 (13%)
Query: 444 RIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKN 503
+IG GSFGS L + +L +K++ L +
Sbjct: 9 QIGKGSFGSALLVRHKHEKKLYVLKKIRL----------------------------ARQ 40
Query: 504 TSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGG-NLNIFLEYVPGGSVSSMLN-- 560
T + R + EM ++ ++H+ IV Y S E G + I + Y GG ++ +
Sbjct: 41 TGRTRR----SAHQEMELISKIHNPFIVEYKDSWVEKGCYVCIIIGYCKGGDMAEAIKKT 96
Query: 561 NYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSP 620
N F E + + QIL+ L YLH +I+HRD+K +NI + +++ DFG++K L+
Sbjct: 97 NGVHFTEEKLCKWLVQILLALEYLHANHILHRDVKCSNIFLTKDQDIRLGDFGLAKVLT- 155
Query: 621 LNKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAI 680
+ +S+ G+ +M PE++ + K+DIWS+GC + EM K F F I
Sbjct: 156 ---SDDLASSVVGTPSYMCPELLADIPYGSKSDIWSLGCCMYEMTAMKPAFKAFDMQGLI 212
Query: 681 FKIGTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
+I +I+P +P+ S + + + RPS+ LL++P L
Sbjct: 213 NRINRSIVPPLPAQYSAAFRGLVKSMLRKNPELRPSAAELLRQPLL 258
>At2g17700 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 546
Score = 108 bits (271), Expect = 2e-23
Identities = 61/212 (28%), Positives = 112/212 (52%), Gaps = 6/212 (2%)
Query: 506 QIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNYG-P 564
+++ +M+ E+ I++++ H+N+V + G+ L I E++ GS+ L+
Sbjct: 319 RVNNEMLREFSQEVFIMRKVRHKNVVQFLGACTRSPTLCIVTEFMARGSIYDFLHKQKCA 378
Query: 565 FDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPLNKQ 624
F + + G++YLH+ NIIHRD+K AN+L+D G VK+ DFG+++ + +
Sbjct: 379 FKLQTLLKVALDVAKGMSYLHQNNIIHRDLKTANLLMDEHGLVKVADFGVAR----VQIE 434
Query: 625 QNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQ-AIFKI 683
+ G+ WMAPEV++ KAD++S V+ E+ TG P+ + +Q A+ +
Sbjct: 435 SGVMTAETGTYRWMAPEVIEHKPYNHKADVFSYAIVLWELLTGDIPYAFLTPLQAAVGVV 494
Query: 684 GTNIIPEIPSWVSEEAKAFLFKSFELDYRKRP 715
+ P+IP + K L + + D +RP
Sbjct: 495 QKGLRPKIPKKTHPKVKGLLERCWHQDPEQRP 526
>7291037 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 396
Score = 108 bits (271), Expect = 2e-23
Identities = 73/237 (30%), Positives = 122/237 (50%), Gaps = 33/237 (13%)
Query: 518 EMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNYGPFDEPLVKNFTRQI 577
E+ +L E + +IV +YG+ G ++I +EY+ GGS+ +L G E ++ T +
Sbjct: 133 ELKVLHECNFPHIVGFYGAFYSDGEISICMEYMDGGSLDLILKRAGRIPESILGRITLAV 192
Query: 578 LIGLAYLHKRN-IIHRDIKGANILIDIKGGVKITDFGISKKLSPLNKQQNKRASLQGSVY 636
L GL+YL + IIHRD+K +NIL++ G +KI DFG+S +L ++ N S G+
Sbjct: 193 LKGLSYLRDNHAIIHRDVKPSNILVNSSGEIKICDFGVSGQL--IDSMAN---SFVGTRS 247
Query: 637 WMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFP----------------------DF 674
+M+PE ++ + ++DIWS+G +VEM G +P P D
Sbjct: 248 YMSPERLQGTHYSVQSDIWSLGLSLVEMAIGMYPIPPPNTATLESIFADNAEESGQPTDE 307
Query: 675 SQMQAIFKIGTNIIPEIPSWVSEEAKAFLFKSF-ELDYRKRPSSLG----LLQEPWL 726
+ AIF++ I+ E P + + + FK F ++ +K+P LL PW+
Sbjct: 308 PRAMAIFELLDYIVNEPPPKLEHKIFSTEFKDFVDICLKKQPDERADLKTLLSHPWI 364
>YPL140c [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 506
Score = 108 bits (270), Expect = 3e-23
Identities = 71/241 (29%), Positives = 124/241 (50%), Gaps = 25/241 (10%)
Query: 503 NTSQIHRKMIDALQHEMNILKELHHENIVTYYG--SSQEGGNLNIFLEYVPGGSVSSMLN 560
NT ++K I E+ K + IV YYG + ++ ++ I +EY+ G S+ +
Sbjct: 249 NTDPEYQKQIF---RELQFNKSFKSDYIVQYYGMFTDEQSSSIYIAMEYMGGKSLEATYK 305
Query: 561 NY----GPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISK 616
N G E ++ +L GL+YLH+R +IHRDIK NIL++ KG +K+ DFG+S
Sbjct: 306 NLLKRGGRISERVIGKIAESVLRGLSYLHERKVIHRDIKPQNILLNEKGEIKLCDFGVSG 365
Query: 617 KLSPLNKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPD--F 674
+ + + G+ ++MAPE ++ + D+WS+G ++E+ G+ PF
Sbjct: 366 E-----AVNSLAMTFTGTSFYMAPERIQGQPYSVTCDVWSLGLTLLEVAGGRFPFESDKI 420
Query: 675 SQMQAIFKIGTNII---------PEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPW 725
+Q A ++ T I+ PE+ S+ ++F+ + D R+RPS +L+ PW
Sbjct: 421 TQNVAPIELLTMILTFSPQLKDEPELDISWSKTFRSFIDYCLKKDARERPSPRQMLKHPW 480
Query: 726 L 726
+
Sbjct: 481 I 481
>YKL139w [D] KOG0600 Cdc2-related protein kinase
Length = 528
Score = 108 bits (270), Expect = 3e-23
Identities = 77/274 (28%), Positives = 133/274 (48%), Gaps = 45/274 (16%)
Query: 427 ISLPTKVEAPKSWLKGARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIAD 486
+S+ T+ + +L+ ++G G++G VY N T +L+A+K++ L+
Sbjct: 171 VSVLTQQRSTSVYLRIMQVGEGTYGKVYKAKNTNTEKLVALKKLRLQ------------- 217
Query: 487 ESKKAHSPGGGNTAVKNTSQIHRKMIDALQH-EMNILKELHHENIVTYYGSSQEGGNLNI 545
G TS K++ + H ++ +KE+ E+ T Y +
Sbjct: 218 ---------GEREGFPITSIREIKLLQSFDHPNVSTIKEIMVESQKTVY----------M 258
Query: 546 FLEYVPGGSVSSMLNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKG 605
EY +LN K+ +Q+L+G+ YLH I+HRD+KG+NILID +G
Sbjct: 259 IFEYADNDLSGLLLNKEVQISHSQCKHLFKQLLLGMEYLHDNKILHRDVKGSNILIDNQG 318
Query: 606 GVKITDFGISKKLSPLNKQQNKRASLQGSVYWMAPEVVKQVVT-TEKADIWSVGCVIVEM 664
+KITDFG+++K++ N+ +L ++ PE++ + D+W GC++VE+
Sbjct: 319 NLKITDFGLARKMNSRADYTNRVITL----WYRPPELLLGTTNYGTEVDMWGCGCLLVEL 374
Query: 665 FTGKHPFP---DFSQMQAIFKI-GTNIIPEIPSW 694
F F + Q+++IFKI GT P I SW
Sbjct: 375 FNKTAIFQGSNELEQIESIFKIMGT---PTINSW 405
>Hs7662210 [OUT] KOG0595 Serine/threonine-protein kinase involved in autophagy
Length = 1036
Score = 108 bits (270), Expect = 3e-23
Identities = 70/223 (31%), Positives = 104/223 (46%), Gaps = 15/223 (6%)
Query: 515 LQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNYGPFDEPLVKNFT 574
L E+ ILKEL HENIV Y + ++ + +EY GG ++ L G E ++ F
Sbjct: 53 LGKEIKILKELQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFL 112
Query: 575 RQILIGLAYLHKRNIIHRDIKGANILIDIKG---------GVKITDFGISKKLSPLNKQQ 625
QI + LH + IIHRD+K NIL+ +KI DFG ++ L
Sbjct: 113 HQIAAAMRILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYL----HSN 168
Query: 626 NKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFS--QMQAIFKI 683
A+L GS +MAPEV+ KAD+WS+G VI + GK PF S ++ ++
Sbjct: 169 MMAATLCGSPMYMAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEK 228
Query: 684 GTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
+++P IP S L + + + R P+L
Sbjct: 229 NRSLMPSIPRETSPYLANLLLGLLQRNQKDRMDFEAFFSHPFL 271
>CE18169 [T] KOG0603 Ribosomal protein S6 kinase
Length = 797
Score = 108 bits (270), Expect = 3e-23
Identities = 65/197 (32%), Positives = 109/197 (54%), Gaps = 4/197 (2%)
Query: 518 EMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNYGPFDEPLVKNFTRQI 577
E NIL + H IV + + Q G L + L+++ GG + + L+ F E VK + ++
Sbjct: 154 ERNILAHISHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEDDVKFYLAEL 213
Query: 578 LIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPLNKQQNKRASLQGSVYW 637
+ L +LH I++RD+K NIL+D G +K+TDFG+SK+ K K S G+V +
Sbjct: 214 TLALEHLHSLGIVYRDLKPENILLDADGHIKVTDFGLSKEAIDSEK---KTYSFCGTVEY 270
Query: 638 MAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAIFKIGTNIIPEIPSWVSE 697
MAPEV+ + + AD WS+G ++ EM TG PF + + +I +P ++++
Sbjct: 271 MAPEVINRRGHSMAADFWSLGVLMFEMLTGHLPFQGRDRNDTMTQI-LKAKLSMPHFLTQ 329
Query: 698 EAKAFLFKSFELDYRKR 714
EA++ L F+ + + R
Sbjct: 330 EAQSLLRALFKRNSQNR 346
Score = 84.7 bits (208), Expect = 5e-16
Identities = 61/234 (26%), Positives = 112/234 (47%), Gaps = 20/234 (8%)
Query: 507 IHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSV-SSMLNNYGPF 565
+ + + DA + +L+ HH+ +V + ++ + + E GG + ++N
Sbjct: 485 VKKAVFDATEEVDILLRHSHHQFVVKLFDVYEDETAIYMIEELCEGGELLDKLVNKKSLG 544
Query: 566 DEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGG----VKITDFGISKKLSPL 621
E V +L + YLH + + HRD+ ANIL +K G ++I DFG +K
Sbjct: 545 SEKEVAAIMANLLNAVQYLHSQQVAHRDLTAANILFALKDGDPSSLRIVDFGFAK----- 599
Query: 622 NKQQNKRASLQGSVY---WMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPF---PDFS 675
+ + + L Y ++APEV+++ D+WS+G ++ M TG PF P+ +
Sbjct: 600 -QSRAENGMLMTPCYTAQFVAPEVLRKQGYDRSCDVWSLGVLLHTMLTGCTPFAMGPNDT 658
Query: 676 QMQAIFKIGTNIIPEI-PSW--VSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
Q + ++G I P W +S+EAK + K ++D +R ++ LQ W+
Sbjct: 659 PDQILQRVGDGKISMTHPVWDTISDEAKDLVRKMLDVDPNRRVTAKQALQHKWI 712
>CE13014 [T] KOG0603 Ribosomal protein S6 kinase
Length = 740
Score = 108 bits (270), Expect = 3e-23
Identities = 65/197 (32%), Positives = 109/197 (54%), Gaps = 4/197 (2%)
Query: 518 EMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNYGPFDEPLVKNFTRQI 577
E NIL + H IV + + Q G L + L+++ GG + + L+ F E VK + ++
Sbjct: 97 ERNILAHISHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEDDVKFYLAEL 156
Query: 578 LIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPLNKQQNKRASLQGSVYW 637
+ L +LH I++RD+K NIL+D G +K+TDFG+SK+ K K S G+V +
Sbjct: 157 TLALEHLHSLGIVYRDLKPENILLDADGHIKVTDFGLSKEAIDSEK---KTYSFCGTVEY 213
Query: 638 MAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAIFKIGTNIIPEIPSWVSE 697
MAPEV+ + + AD WS+G ++ EM TG PF + + +I +P ++++
Sbjct: 214 MAPEVINRRGHSMAADFWSLGVLMFEMLTGHLPFQGRDRNDTMTQI-LKAKLSMPHFLTQ 272
Query: 698 EAKAFLFKSFELDYRKR 714
EA++ L F+ + + R
Sbjct: 273 EAQSLLRALFKRNSQNR 289
Score = 84.7 bits (208), Expect = 5e-16
Identities = 61/234 (26%), Positives = 112/234 (47%), Gaps = 20/234 (8%)
Query: 507 IHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSV-SSMLNNYGPF 565
+ + + DA + +L+ HH+ +V + ++ + + E GG + ++N
Sbjct: 428 VKKAVFDATEEVDILLRHSHHQFVVKLFDVYEDETAIYMIEELCEGGELLDKLVNKKSLG 487
Query: 566 DEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGG----VKITDFGISKKLSPL 621
E V +L + YLH + + HRD+ ANIL +K G ++I DFG +K
Sbjct: 488 SEKEVAAIMANLLNAVQYLHSQQVAHRDLTAANILFALKDGDPSSLRIVDFGFAK----- 542
Query: 622 NKQQNKRASLQGSVY---WMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPF---PDFS 675
+ + + L Y ++APEV+++ D+WS+G ++ M TG PF P+ +
Sbjct: 543 -QSRAENGMLMTPCYTAQFVAPEVLRKQGYDRSCDVWSLGVLLHTMLTGCTPFAMGPNDT 601
Query: 676 QMQAIFKIGTNIIPEI-PSW--VSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
Q + ++G I P W +S+EAK + K ++D +R ++ LQ W+
Sbjct: 602 PDQILQRVGDGKISMTHPVWDTISDEAKDLVRKMLDVDPNRRVTAKQALQHKWI 655
>At4g35780 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 553
Score = 108 bits (270), Expect = 3e-23
Identities = 61/219 (27%), Positives = 117/219 (52%), Gaps = 6/219 (2%)
Query: 506 QIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNY-GP 564
+++ +M+ E+ I++++ H+N+V + G+ NL I E++ GS+ L+ + G
Sbjct: 308 RVNAEMLREFSQEVYIMRKVRHKNVVQFIGACTRSPNLCIVTEFMTRGSIYDFLHKHKGV 367
Query: 565 FDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPLNKQ 624
F + + G+ YLH+ NIIHRD+K AN+L+D VK+ DFG+++ + +
Sbjct: 368 FKIQSLLKVALDVSKGMNYLHQNNIIHRDLKTANLLMDEHEVVKVADFGVAR----VQTE 423
Query: 625 QNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQ-AIFKI 683
+ G+ WMAPEV++ +AD++S V+ E+ TG+ P+ + +Q A+ +
Sbjct: 424 SGVMTAETGTYRWMAPEVIEHKPYDHRADVFSYAIVLWELLTGELPYSYLTPLQAAVGVV 483
Query: 684 GTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQ 722
+ P+IP + L K ++ D RP+ +++
Sbjct: 484 QKGLRPKIPKETHPKLTELLEKCWQQDPALRPNFAEIIE 522
>At2g26980 [T] KOG0583 Serine/threonine protein kinase
Length = 441
Score = 108 bits (270), Expect = 3e-23
Identities = 78/285 (27%), Positives = 128/285 (44%), Gaps = 34/285 (11%)
Query: 442 GARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAV 501
G IG G+F V N+ETGE +A+K I D+ K
Sbjct: 17 GRTIGEGTFAKVKFARNSETGEPVALK---------------ILDKEKV----------- 50
Query: 502 KNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNN 561
+ KM + ++ E+ +K + H N+V Y + I LEYV GG + + N
Sbjct: 51 -----LKHKMAEQIRREIATMKLIKHPNVVQLYEVMASKTKIFIILEYVTGGELFDKIVN 105
Query: 562 YGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPL 621
G E + + +Q++ + Y H R + HRD+K N+L+D G +KI+DFG+S LS
Sbjct: 106 DGRMKEDEARRYFQQLIHAVDYCHSRGVYHRDLKPENLLLDSYGNLKISDFGLS-ALSQQ 164
Query: 622 NKQQNKRASLQGSVYWMAPEVVK-QVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAI 680
+ + G+ ++APEV+ + AD+WS G V+ + G PF D + M
Sbjct: 165 VRDDGLLHTSCGTPNYVAPEVLNDRGYDGATADMWSCGVVLYVLLAGYLPFDDSNLMNLY 224
Query: 681 FKIGTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPW 725
KI + P W+S A + + + + R + + ++ W
Sbjct: 225 KKISSGEF-NCPPWLSLGAMKLITRILDPNPMTRVTPQEVFEDEW 268
>7293601 [T] KOG0577 Serine/threonine protein kinase
Length = 1039
Score = 108 bits (270), Expect = 3e-23
Identities = 83/287 (28%), Positives = 127/287 (43%), Gaps = 44/287 (15%)
Query: 445 IGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKNT 504
IG GSFG+VY T E++A+K++
Sbjct: 33 IGHGSFGAVYYARCNLTREIVAIKKMSY------------------------------TG 62
Query: 505 SQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNYGP 564
Q K D L+ E+ L++L+H N + Y G + +EY G + + + P
Sbjct: 63 KQSQEKWQDILK-EIRFLRQLNHPNTIEYKGCYLRESTAWLVMEYCVGSASDIIEVHKKP 121
Query: 565 FDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPLNKQ 624
E + +L GL+YLH IHRDIK NIL+ G VK+ DFG + P N
Sbjct: 122 LHEDEIAAICLGVLSGLSYLHSLGRIHRDIKAGNILLTDNGVVKLADFGSAAIKCPAN-- 179
Query: 625 QNKRASLQGSVYWMAPEVVKQVVTTE---KADIWSVGCVIVEMFTGKHPFPDFSQMQAIF 681
S G+ YWMAPEV+ + + K D+WS+G +E+ K P+ + + M A++
Sbjct: 180 -----SFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPYFNMNAMSALY 234
Query: 682 KIGTNIIPEIP--SWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
I N P +P W S+ +F+ + +RPSS LL ++
Sbjct: 235 HIAQNESPTLPKNDW-SDAFCSFVELCLKKMPAERPSSAKLLTHAYV 280
>YPL031c [R] KOG0594 Protein kinase PCTAIRE and related kinases
Length = 305
Score = 108 bits (269), Expect = 4e-23
Identities = 77/250 (30%), Positives = 125/250 (49%), Gaps = 47/250 (18%)
Query: 444 RIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKN 503
++G+G++ +VY G+N TG +A+K+V+L G +TA++
Sbjct: 12 KLGNGTYATVYKGLNKTTGVYVALKEVKLDS------------------EEGTPSTAIR- 52
Query: 504 TSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSML---- 559
E++++KEL HENIV Y L + E++ M
Sbjct: 53 --------------EISLMKELKHENIVRLYDVIHTENKLTLVFEFMDNDLKKYMDSRTV 98
Query: 560 -NNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKL 618
N + LVK F Q+L GLA+ H+ I+HRD+K N+LI+ +G +K+ DFG+++
Sbjct: 99 GNTPRGLELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAF 158
Query: 619 S-PLNKQQNKRASLQGSVYWMAPEVVKQVVT-TEKADIWSVGCVIVEMFTGKHPFP---D 673
P+N ++ +L ++ AP+V+ T + DIWS GC++ EM TGK FP D
Sbjct: 159 GIPVNTFSSEVVTL----WYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTND 214
Query: 674 FSQMQAIFKI 683
Q++ IF I
Sbjct: 215 EEQLKLIFDI 224
>Hs7661974 [T] KOG0583 Serine/threonine protein kinase
Length = 651
Score = 108 bits (269), Expect = 4e-23
Identities = 77/285 (27%), Positives = 132/285 (46%), Gaps = 41/285 (14%)
Query: 445 IGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKNT 504
IG+G F V L + TGE++A+K ++ KNT
Sbjct: 17 IGTGGFAKVKLACHILTGEMVAIKIMD------------------------------KNT 46
Query: 505 --SQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNY 562
S + R ++ E+ LK L H++I Y + + + LEY PGG + + +
Sbjct: 47 LGSDLPR-----IKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQ 101
Query: 563 GPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPLN 622
E + RQI+ +AY+H + HRD+K N+L D +K+ DFG+ K P
Sbjct: 102 DRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAK--PKG 159
Query: 623 KQQNKRASLQGSVYWMAPEVVK-QVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAIF 681
+ + GS+ + APE+++ + +AD+WS+G ++ + G PF D + A++
Sbjct: 160 NKDYHLQTCCGSLAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDD-DNVMALY 218
Query: 682 KIGTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
K ++P W+S + L + ++D +KR S LL PW+
Sbjct: 219 KKIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWI 263
>Hs5730055 [D] KOG0575 Polo-like serine/threonine protein kinase
Length = 685
Score = 108 bits (269), Expect = 4e-23
Identities = 60/204 (29%), Positives = 115/204 (55%), Gaps = 4/204 (1%)
Query: 513 DALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNYGPFDEPLVKN 572
+ + E+ + + LHH+++V +Y ++ N+ I LEY S++ +L EP V+
Sbjct: 125 EKIDKEIELHRILHHKHVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRY 184
Query: 573 FTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPLNKQQNKRASLQ 632
+ RQI+ GL YLH++ I+HRD+K N I+ +K+ DFG++ +L PL +++R ++
Sbjct: 185 YLRQIVSGLKYLHEQEILHRDLKLGNFFINEAMELKVGDFGLAARLEPL---EHRRRTIC 241
Query: 633 GSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAIFKIGTNIIPEIP 692
G+ +++PEV+ + ++DIW++GCV+ M G+ PF + + ++ ++ +P
Sbjct: 242 GTPNYLSPEVLNKQGHGCESDIWALGCVMYTMLLGRPPF-ETTNLKETYRCIREARYTMP 300
Query: 693 SWVSEEAKAFLFKSFELDYRKRPS 716
S + AK + + RPS
Sbjct: 301 SSLLAPAKHLIASMLSKNPEDRPS 324
>Hs10835065 [T] KOG0616 cAMP-dependent protein kinase catalytic subunit (PKA)
Length = 277
Score = 108 bits (269), Expect = 4e-23
Identities = 70/229 (30%), Positives = 113/229 (48%), Gaps = 37/229 (16%)
Query: 445 IGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKNT 504
+G+G+FG V+L A+K V+SI D
Sbjct: 55 MGTGTFGRVHLVKEKTAKHFFALK------------VMSIPDV----------------- 85
Query: 505 SQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNYGP 564
I RK + +E ++LKE+ H ++ + + E L + +EYVPGG + S L N G
Sbjct: 86 --IRRKQEQHVHNEKSVLKEVSHPFLIRLFWTWHEERFLYMLMEYVPGGELFSYLRNRGH 143
Query: 565 FDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPLNKQ 624
F ++ +I+ + YLH + I++RD+K NIL+D G +K+TDFG +KKL
Sbjct: 144 FSSTTGLFYSAEIICAIEYLHSKEIVYRDLKPENILLDRDGHIKLTDFGFAKKL------ 197
Query: 625 QNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPD 673
++ +L G+ ++APEV++ D W++G +I EM +G PF D
Sbjct: 198 VDRTWTLCGTPEYLAPEVIQSKGHGRAVDWWALGILIFEMLSGFPPFFD 246
>CE27768 [R] KOG0586 Serine/threonine protein kinase
Length = 1096
Score = 108 bits (269), Expect = 4e-23
Identities = 80/284 (28%), Positives = 131/284 (45%), Gaps = 38/284 (13%)
Query: 445 IGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKNT 504
IG G+F V L + TG +A+K ++ TA+ +
Sbjct: 128 IGKGNFAKVKLAKHVITGHEVAIKIID--------------------------KTALNPS 161
Query: 505 SQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNYGP 564
S + L E+ I+K+L H NIV Y + L + LEY GG V L +G
Sbjct: 162 S------LQKLFREVKIMKQLDHPNIVKLYQVMETEQTLYLVLEYASGGEVFDYLVAHGR 215
Query: 565 FDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPLNKQ 624
E + RQI+ + YLH +NIIHRD+K N+L+D +KI DFG S S
Sbjct: 216 MKEKEARAKFRQIVSAVQYLHSKNIIHRDLKAENLLLDQDMNIKIADFGFSNTFS----L 271
Query: 625 QNKRASLQGSVYWMAPEVVK-QVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAIFKI 683
NK + GS + APE+ + + D+WS+G ++ + +G PF D ++ + +
Sbjct: 272 GNKLDTFCGSPPYAAPELFSGKKYDGPEVDVWSLGVILYTLVSGSLPF-DGQNLKELRER 330
Query: 684 GTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWLN 727
IP ++S + + L K ++ ++R S ++++ W+N
Sbjct: 331 VLRGKYRIPFYMSTDCENLLKKFLVINPQRRSSLDNIMKDRWMN 374
>CE26212 [T] KOG0582 Ste20-like serine/threonine protein kinase
Length = 545
Score = 108 bits (269), Expect = 4e-23
Identities = 75/235 (31%), Positives = 119/235 (49%), Gaps = 24/235 (10%)
Query: 512 IDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNN---------- 561
+D L HE+ + + +H N+V+YY S L + + + GS+ +L
Sbjct: 97 VDELSHEIQAMSQCNHPNVVSYYTSFIAQEELWVVMRLLNCGSMLDILKRKVKAIGKEQA 156
Query: 562 -YGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSP 620
+G DE + R++L GL Y H IHRDIK NIL+ G ++I DFG+S L+
Sbjct: 157 QFGVLDEVSIATVLREVLKGLEYFHLNGQIHRDIKAGNILLADDGTIQIADFGVSGWLAS 216
Query: 621 LN---KQQNKRASLQGSVYWMAPEVVKQVVTTE-KADIWSVGCVIVEMFTGKHPFPDFSQ 676
+Q R + G+ WMAPEV++QV + KADIWS+G + +E+ TG P+ +
Sbjct: 217 SGGDLSRQKVRHTFVGTPCWMAPEVMEQVQGYDFKADIWSLGILAIELATGTAPYHKYPP 276
Query: 677 MQAIFKIGTNIIP--EIPSWVSEEAKAF--LFKS-----FELDYRKRPSSLGLLQ 722
M+ + N P E + ++ KA+ FK+ + D KRP++ LL+
Sbjct: 277 MKVLMLTLQNDPPTLETNAERKDQYKAYGKSFKTLIRDCLQKDPAKRPTASELLK 331
>CE23838 [R] KOG0586 Serine/threonine protein kinase
Length = 1192
Score = 108 bits (269), Expect = 4e-23
Identities = 80/284 (28%), Positives = 131/284 (45%), Gaps = 38/284 (13%)
Query: 445 IGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKNT 504
IG G+F V L + TG +A+K ++ TA+ +
Sbjct: 176 IGKGNFAKVKLAKHVITGHEVAIKIID--------------------------KTALNPS 209
Query: 505 SQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNYGP 564
S + L E+ I+K+L H NIV Y + L + LEY GG V L +G
Sbjct: 210 S------LQKLFREVKIMKQLDHPNIVKLYQVMETEQTLYLVLEYASGGEVFDYLVAHGR 263
Query: 565 FDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPLNKQ 624
E + RQI+ + YLH +NIIHRD+K N+L+D +KI DFG S S
Sbjct: 264 MKEKEARAKFRQIVSAVQYLHSKNIIHRDLKAENLLLDQDMNIKIADFGFSNTFS----L 319
Query: 625 QNKRASLQGSVYWMAPEVVK-QVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAIFKI 683
NK + GS + APE+ + + D+WS+G ++ + +G PF D ++ + +
Sbjct: 320 GNKLDTFCGSPPYAAPELFSGKKYDGPEVDVWSLGVILYTLVSGSLPF-DGQNLKELRER 378
Query: 684 GTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWLN 727
IP ++S + + L K ++ ++R S ++++ W+N
Sbjct: 379 VLRGKYRIPFYMSTDCENLLKKFLVINPQRRSSLDNIMKDRWMN 422
>At5g45810 [T] KOG0583 Serine/threonine protein kinase
Length = 483
Score = 108 bits (269), Expect = 4e-23
Identities = 74/285 (25%), Positives = 134/285 (46%), Gaps = 35/285 (12%)
Query: 442 GARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAV 501
G +G G+F VYL NA++GE +A+K ++ K + +G++ AH
Sbjct: 31 GRLLGHGTFAKVYLARNAQSGESVAIKVID-KEKVLKSGLI--------AH--------- 72
Query: 502 KNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNN 561
++ E++IL+ + H NIV + + +EYV GG + + +
Sbjct: 73 -------------IKREISILRRVRHPNIVQLFEVMATKSKIYFVMEYVKGGELFNKVAK 119
Query: 562 YGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPL 621
G E + + + +Q++ +++ H R + HRD+K N+L+D G +K++DFG+S +S
Sbjct: 120 -GRLKEEMARKYFQQLISAVSFCHFRGVYHRDLKPENLLLDENGNLKVSDFGLS-AVSDQ 177
Query: 622 NKQQNKRASLQGSVYWMAPEVV-KQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAI 680
+Q + G+ ++APEV+ ++ K DIWS G ++ + G PF D + M
Sbjct: 178 IRQDGLFHTFCGTPAYVAPEVLARKGYDGAKVDIWSCGVILFVLMAGFLPFHDRNVMAMY 237
Query: 681 FKIGTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPW 725
KI P W E L + E +R + +++ W
Sbjct: 238 KKIYRGDF-RCPRWFPVEINRLLIRMLETKPERRFTMPDIMETSW 281
>At4g10010 [D] KOG0600 Cdc2-related protein kinase
Length = 649
Score = 108 bits (269), Expect = 4e-23
Identities = 81/265 (30%), Positives = 130/265 (48%), Gaps = 52/265 (19%)
Query: 434 EAPKSWL--------KGARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIA 485
EA K W+ K +IG G++ SVY + ETG+++A+K+V V++
Sbjct: 143 EAIKGWVPRRAESFEKLDKIGQGTYSSVYRARDLETGKMVAMKKVRF---------VNMD 193
Query: 486 DESKKAHSPGGGNTAVKNTSQIHRKMIDALQHEMNILKELHHENIVTY--YGSSQEGGNL 543
ES + + E+NIL++L H N++ +S+ G+L
Sbjct: 194 PES-----------------------VRFMAREINILRKLDHPNVMKLECLVTSKLSGSL 230
Query: 544 NIFLEYVPGGSVSSMLNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDI 603
+ EY+ L F E +K + +Q+L GL + H R I+HRDIKG N+L++
Sbjct: 231 YLVFEYMEHDLSGLALRPGVKFTESQIKCYMKQLLSGLEHCHSRGILHRDIKGPNLLVNN 290
Query: 604 KGGVKITDFGISKKLSPLNKQQNKRASLQGSVYWMAPEVVKQVVTTEKA---DIWSVGCV 660
G +KI DFG++ P +Q S ++++ APE++ + TE D+WSVGC+
Sbjct: 291 DGVLKIGDFGLANIYHP--EQDQPLTSRVVTLWYRAPELL--LGATEYGPGIDLWSVGCI 346
Query: 661 IVEMFTGKHPFP---DFSQMQAIFK 682
+ E+F GK P + QM IFK
Sbjct: 347 LTELFLGKPIMPGRTEVEQMHKIFK 371
>At3g01090 [T] KOG0583 Serine/threonine protein kinase
Length = 512
Score = 108 bits (269), Expect = 4e-23
Identities = 78/290 (26%), Positives = 134/290 (45%), Gaps = 37/290 (12%)
Query: 442 GARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAV 501
G +G GSFG V + +A TG +A+K + + +
Sbjct: 22 GRTLGIGSFGRVKIAEHALTGHKVAIKILNRRK--------------------------I 55
Query: 502 KNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNN 561
KN +M + ++ E+ IL+ H +I+ Y + ++ + +EYV G + +
Sbjct: 56 KNM-----EMEEKVRREIKILRLFMHPHIIRLYEVIETPTDIYLVMEYVNSGELFDYIVE 110
Query: 562 YGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPL 621
G E +NF +QI+ G+ Y H+ ++HRD+K N+L+D K VKI DFG LS +
Sbjct: 111 KGRLQEDEARNFFQQIISGVEYCHRNMVVHRDLKPENLLLDSKCNVKIADFG----LSNI 166
Query: 622 NKQQNKRASLQGSVYWMAPEVVK-QVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAI 680
+ + + GS + APEV+ ++ + D+WS G ++ + G PF D + +
Sbjct: 167 MRDGHFLKTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYALLCGTLPFDD-ENIPNL 225
Query: 681 FKIGTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWLNTVL 730
FK I +PS +S A+ + + +D KR + + Q PW L
Sbjct: 226 FKKIKGGIYTLPSHLSPGARDLIPRMLVVDPMKRVTIPEIRQHPWFQAHL 275
>At2g05060 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 315
Score = 108 bits (269), Expect = 4e-23
Identities = 79/237 (33%), Positives = 122/237 (51%), Gaps = 16/237 (6%)
Query: 500 AVKNTSQIHRKMIDALQHEMNILKELHH-ENIVTYYGS------SQEGG-NLNIFLEYVP 551
AVK ++ IH D+L E IL E IV YG+ ++EG I +EY
Sbjct: 45 AVKTSNIIHA---DSLLKEFQILSEFKGCSRIVQCYGTKVQETINEEGDVEFTIPMEYAS 101
Query: 552 GGSVSSMLNNYGPFDEP--LVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKI 609
GGS+ ++ + P L++ FTR IL GLA +H +H D+K NIL+ +KI
Sbjct: 102 GGSLRHFMSRFKDMKLPDALIRRFTRMILEGLAVIHGHGYVHCDLKPENILVFPSFELKI 161
Query: 610 TDFGISKKLSPLNKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKH 669
+DFG+SK+ +K G+ +M+PE + T D+WS+GCV++EM+TGK
Sbjct: 162 SDFGLSKREGD-SKWWLPSHPFAGTPVYMSPESISNGETRRGLDLWSLGCVVLEMYTGKR 220
Query: 670 PFPDFSQMQAIFKIGTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
P+ D + K G+ +P I + +AK F+ F + KR ++ LL+ +L
Sbjct: 221 PWWDKNYDLGDLKKGS--MPLISKDIPCDAKLFVMTCFASETNKRKNAFTLLRHCFL 275
>7302464 [R] KOG0586 Serine/threonine protein kinase
Length = 739
Score = 108 bits (269), Expect = 4e-23
Identities = 74/253 (29%), Positives = 126/253 (49%), Gaps = 8/253 (3%)
Query: 478 TAGVVSIADESKKAHSPGGGNTAVK--NTSQIHRKMIDALQHEMNILKELHHENIVTYYG 535
T G + A H P G A+K + +Q++ + L E+ I+K L H NIV +
Sbjct: 156 TIGKGNFAKVKLAKHLPTGKEVAIKIIDKTQLNPGSLQKLFREVRIMKMLDHPNIVKLFQ 215
Query: 536 SSQEGGNLNIFLEYVPGGSVSSMLNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIK 595
+ L + +EY GG V L +G E + RQI+ + Y H++ IIHRD+K
Sbjct: 216 VIETEKTLYLIMEYASGGEVFDYLVLHGRMKEKEARVKFRQIVSAVQYCHQKRIIHRDLK 275
Query: 596 GANILIDIKGGVKITDFGISKKLSPLNKQQNKRASLQGSVYWMAPEVVK-QVVTTEKADI 654
N+L+D + +KI DFG S + +P +K + GS + APE+ + + + D+
Sbjct: 276 AENLLLDSELNIKIADFGFSNEFTP----GSKLDTFCGSPPYAAPELFQGKKYDGPEVDV 331
Query: 655 WSVGCVIVEMFTGKHPFPDFSQMQAIFKIGTNIIPEIPSWVSEEAKAFLFKSFELDYRKR 714
WS+G ++ + +G PF D S ++ + + IP ++S + + L K L+ KR
Sbjct: 332 WSLGVILYTLVSGSLPF-DGSTLRELRERVLRGKYRIPFYMSTDCENLLRKFLVLNPAKR 390
Query: 715 PSSLGLLQEPWLN 727
S ++ + W+N
Sbjct: 391 ASLETIMGDKWMN 403
>YPL153c [D] KOG0615 Serine/threonine protein kinase Chk2 and related
proteins
Length = 821
Score = 107 bits (268), Expect = 5e-23
Identities = 81/260 (31%), Positives = 130/260 (49%), Gaps = 28/260 (10%)
Query: 489 KKAHSPGGGNT-AVKNTSQIHRKMI---DALQHEMNILKELHHENIVTYYGSSQEGGNLN 544
KKA G T AVK S+ RK+I D + E+ +L++L+H IV G ++ +
Sbjct: 213 KKAIERTTGKTFAVKIISK--RKVIGNMDGVTRELEVLQKLNHPRIVRLKGFYEDTESYY 270
Query: 545 IFLEYVPGGSVSSMLNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILI--D 602
+ +E+V GG + + +G E + +RQIL + Y+H I HRD+K NILI D
Sbjct: 271 MVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHSMGISHRDLKPDNILIEQD 330
Query: 603 IKGGVKITDFGISKKLSPLNKQQNKRASLQGSVYWMAPEVVKQVVT-------------T 649
VKITDFG++K + + + G++ ++APEV++ T +
Sbjct: 331 DPVLVKITDFGLAK----VQGNGSFMKTFCGTLAYVAPEVIRGKDTSVSPDEYEERNEYS 386
Query: 650 EKADIWSVGCVIVEMFTGKHPFPDFSQMQAIFKIGTNIIPEIP---SWVSEEAKAFLFKS 706
D+WS+GC++ + TG PF +Q Q +IG E P +SEEA+ F+
Sbjct: 387 SLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGRGSYHEGPLKDFRISEEARDFIDSL 446
Query: 707 FELDYRKRPSSLGLLQEPWL 726
++D R ++ L PW+
Sbjct: 447 LQVDPNNRSTAAKALNHPWI 466
>Hs4826948 [T] KOG0616 cAMP-dependent protein kinase catalytic subunit (PKA)
Length = 358
Score = 107 bits (268), Expect = 5e-23
Identities = 77/272 (28%), Positives = 129/272 (47%), Gaps = 38/272 (13%)
Query: 443 ARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVK 502
A +G+G+FG V+L A+K V+SI D + +K
Sbjct: 53 ATVGTGTFGRVHLVKEKTAKHFFALK------------VMSIPDVIR-----------LK 89
Query: 503 NTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNY 562
+H +E ++LKE+ H ++ + + + L + +EYVPGG + S L N
Sbjct: 90 QEQHVH--------NEKSVLKEVSHPFLIRLFWTWHDERFLYMLMEYVPGGELFSYLRNR 141
Query: 563 GPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPLN 622
G F ++ +I+ + YLH + I++RD+K NIL+D G +K+TDFG +KKL
Sbjct: 142 GRFSSTTGLFYSAEIICAIEYLHSKEIVYRDLKPENILLDRDGHIKLTDFGFAKKL---- 197
Query: 623 KQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAIFK 682
++ +L G+ ++APEV++ D W++G +I EM +G PF D + K
Sbjct: 198 --VDRTWTLCGTPEYLAPEVIQSKGHGRAVDWWALGILIFEMLSGFPPFFDDNPFGIYQK 255
Query: 683 IGTNIIPEIPSWVSEEAKAFLFKSFELDYRKR 714
I I + P + K + K +D +R
Sbjct: 256 ILAGKI-DFPRHLDFHVKDLIKKLLVVDRTRR 286
>Hs16936528 [R] KOG0594 Protein kinase PCTAIRE and related kinases
Length = 298
Score = 107 bits (268), Expect = 5e-23
Identities = 87/324 (26%), Positives = 147/324 (44%), Gaps = 67/324 (20%)
Query: 437 KSWLKGARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGG 496
+++ K +IG G++G VY N TGE++A+K++ L T GV S
Sbjct: 2 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTE--TEGVPS------------- 46
Query: 497 GNTAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVS 556
TA++ E+++LKEL+H NIV L + E++
Sbjct: 47 --TAIR---------------EISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKK 89
Query: 557 SM-LNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGIS 615
M + PL+K++ Q+L GLA+ H ++HRD+K N+LI+ +G +K+ DFG++
Sbjct: 90 FMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLA 149
Query: 616 KKLS-PLNKQQNKRASLQGSVYWMAPEVVKQVVTTEKA-DIWSVGCVIVEMFTGKHPFPD 673
+ P+ ++ +L ++ APE++ A DIWS+GC+ EM T + FP
Sbjct: 150 RAFGVPVRTYTHEVVTL----WYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPG 205
Query: 674 FSQMQAIFKI----GT-------------NIIPEIPSW-----------VSEEAKAFLFK 705
S++ +F+I GT + P P W + E+ ++ L +
Sbjct: 206 DSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQ 265
Query: 706 SFELDYRKRPSSLGLLQEPWLNTV 729
D KR S+ L P+ V
Sbjct: 266 MLHYDPNKRISAKAALAHPFFQDV 289
>At5g01810 [T] KOG0583 Serine/threonine protein kinase
Length = 421
Score = 107 bits (268), Expect = 5e-23
Identities = 72/285 (25%), Positives = 137/285 (47%), Gaps = 35/285 (12%)
Query: 442 GARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAV 501
G +G G+F VY + +TG+ +A+K ++ K + G
Sbjct: 15 GKFLGQGTFAKVYHARHLKTGDSVAIKVID-KERILKVG--------------------- 52
Query: 502 KNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNN 561
M + ++ E++ ++ L H NIV + + +E+V GG + + ++
Sbjct: 53 ---------MTEQIKREISAMRLLRHPNIVELHEVMATKSKIYFVMEHVKGGELFNKVST 103
Query: 562 YGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPL 621
G E + + + +Q++ + + H R + HRD+K N+L+D G +KI+DFG+S LS
Sbjct: 104 -GKLREDVARKYFQQLVRAVDFCHSRGVCHRDLKPENLLLDEHGNLKISDFGLS-ALSDS 161
Query: 622 NKQQNKRASLQGSVYWMAPEVV-KQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAI 680
+Q + G+ ++APEV+ + KAD+WS G ++ + G PF D + M+
Sbjct: 162 RRQDGLLHTTCGTPAYVAPEVISRNGYDGFKADVWSCGVILFVLLAGYLPFRDSNLMELY 221
Query: 681 FKIGTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPW 725
KIG + + P+W++ AK L + + + R S+ +++ W
Sbjct: 222 KKIGKAEV-KFPNWLAPGAKRLLKRILDPNPNTRVSTEKIMKSSW 265
>At4g38470 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 545
Score = 107 bits (268), Expect = 5e-23
Identities = 65/207 (31%), Positives = 108/207 (51%), Gaps = 22/207 (10%)
Query: 518 EMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNY-GPFDEPLVKNFTRQ 576
E+ I++++ H+N+V + G+ + +L I E++PGGSV L+ G F P +
Sbjct: 323 EVFIMRKVRHKNVVQFIGACTKPPHLCIVTEFMPGGSVYDYLHKQKGVFKLPTLFKVAID 382
Query: 577 ILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPLNKQQNKRASLQGSVY 636
I G++YLH+ NIIHRD+K AN+L+D VK+ DFG+++ + Q + G+
Sbjct: 383 ICKGMSYLHQNNIIHRDLKAANLLMDENEVVKVADFGVAR----VKAQTGVMTAETGTYR 438
Query: 637 WMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAIFKIGTNIIPEIPSWVS 696
WMAPEV++ KAD++S G V+ E+ TGK + P IP
Sbjct: 439 WMAPEVIEHKPYDHKADVFSYGIVLWELLTGK-----------------GLRPTIPKNTH 481
Query: 697 EEAKAFLFKSFELDYRKRPSSLGLLQE 723
+ L + +E D +RP ++++
Sbjct: 482 PKLAELLERLWEHDSTQRPDFSEIIEQ 508
>At3g17850 [TR] KOG0606 Microtubule-associated serine/threonine kinase and
related proteins
Length = 1263
Score = 107 bits (268), Expect = 5e-23
Identities = 78/305 (25%), Positives = 133/305 (43%), Gaps = 61/305 (20%)
Query: 445 IGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKNT 504
I G+FG V+L TG+L A+K +K
Sbjct: 896 ISRGAFGRVFLAKKRTTGDLFAIK-------------------------------VLKKA 924
Query: 505 SQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNYGP 564
I + ++++ E +IL + + +V ++ S NL + +EY+ GG + S+L N G
Sbjct: 925 DMIRKNAVESILAERDILINVRNPFVVRFFYSFTCRDNLYLVMEYLNGGDLYSLLRNLGC 984
Query: 565 FDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISK-------- 616
+E +V+ + ++++ L YLH ++HRD+K N+LI G +K+TDFG+SK
Sbjct: 985 LEEDIVRVYIAEVVLALEYLHSEGVVHRDLKPDNLLIAHDGHIKLTDFGLSKVGLINSTD 1044
Query: 617 ------------------KLSPLNKQ--QNKRASLQGSVYWMAPEVVKQVVTTEKADIWS 656
+L+ +Q + K+ S G+ ++APE++ AD WS
Sbjct: 1045 DLAGPAVSGTSLLDEEESRLAASEEQLERRKKRSAVGTPDYLAPEILLGTGHGATADWWS 1104
Query: 657 VGCVIVEMFTGKHPFPDFSQMQAIFKIGTNII--PEIPSWVSEEAKAFLFKSFELDYRKR 714
VG ++ E+ G PF Q I I P +P +S EA + + D +R
Sbjct: 1105 VGIILFELIVGIPPFNAEHPQQIFDNILNRKIPWPHVPEEMSAEAHDIIDRFLTEDPHQR 1164
Query: 715 PSSLG 719
+ G
Sbjct: 1165 LGARG 1169
>At1g18160 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 990
Score = 107 bits (268), Expect = 5e-23
Identities = 76/242 (31%), Positives = 123/242 (50%), Gaps = 17/242 (7%)
Query: 496 GGNTAVKN--TSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGG 553
G AVK I + ++ + E+ +++ L H NIV + G+ NL+I E++P G
Sbjct: 734 GTAVAVKKFIDQDITGEALEEFRSEVRMMRRLRHPNIVLFMGAVTRPPNLSIVTEFLPRG 793
Query: 554 SVSSMLNN-YGPFDEPLVKNFTRQILIGLAYLHKRN--IIHRDIKGANILIDIKGGVKIT 610
S+ +++ DE G+ YLH N I+HRD+K N+L+D VK+
Sbjct: 794 SLYRLIHRPNNQLDERKRLRMALDAARGMNYLHSCNPVIVHRDLKSPNLLVDKNWVVKVC 853
Query: 611 DFGISK-KLSPLNKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKH 669
DFG+S+ K+S + S G+ WMAPEV++ EK D++S G ++ E+FT +
Sbjct: 854 DFGLSRMKVSTYLSSK----STAGTAEWMAPEVLRNEPADEKCDVYSYGVILWELFTLQQ 909
Query: 670 PFPDFSQMQAIFKIG-TNIIPEIPSWVSEEAKAFLFKSFELDYRKRPS------SLGLLQ 722
P+ + MQ + +G + +IP +V + K ++ D R RPS SL LQ
Sbjct: 910 PWGKMNPMQVVGAVGFQHRRLDIPEFVDPGIADIIRKCWQTDPRLRPSFGEIMDSLKQLQ 969
Query: 723 EP 724
+P
Sbjct: 970 KP 971
>7294537 [OUT] KOG0595 Serine/threonine-protein kinase involved in autophagy
Length = 835
Score = 107 bits (268), Expect = 5e-23
Identities = 73/231 (31%), Positives = 120/231 (51%), Gaps = 24/231 (10%)
Query: 489 KKAHSPGGGNTAVKN-TSQIHRKMIDALQHEMNILKEL---HHENIVTYYGSSQEGGNLN 544
+K H P A+K T + K + L E+ ILKEL HHEN+V + ++
Sbjct: 29 RKKHMP----VAIKCITKKGQLKTQNLLGKEIKILKELTELHHENVVALLDCKESQDCVS 84
Query: 545 IFLEYVPGGSVSSMLNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIK 604
+ +EY GG ++ L+ G E V+ F Q+ + L+ + I+HRD+K NIL+
Sbjct: 85 LVMEYCNGGDLADYLSVKGTLSEDTVRLFLVQLAGAMKALYTKGIVHRDLKPQNILLSHN 144
Query: 605 GG----------VKITDFGISKKLSPLNKQQNKRASLQGSVYWMAPEVVKQVVTTEKADI 654
G +KI DFG ++ L+ + A+L GS +MAPEV+ + KAD+
Sbjct: 145 YGKTLPAPSKITLKIADFGFARFLN----EGAMAATLCGSPMYMAPEVIMSLQYDSKADL 200
Query: 655 WSVGCVIVEMFTGKHPF--PDFSQMQAIFKIGTNIIPEIPSWVSEEAKAFL 703
WS+G ++ + TGK PF +++++ ++ N+ P+IPS VS + + L
Sbjct: 201 WSLGTIVYQCLTGKAPFYAQTPNELKSYYEQNANLAPKIPSGVSPDLRDLL 251
>At3g29160 [T] KOG0583 Serine/threonine protein kinase
Length = 512
Score = 107 bits (267), Expect = 6e-23
Identities = 75/290 (25%), Positives = 134/290 (45%), Gaps = 37/290 (12%)
Query: 442 GARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAV 501
G +G GSFG V + + TG +A+K + + +
Sbjct: 23 GKTLGIGSFGKVKIAEHVVTGHKVAIKILNRRK--------------------------I 56
Query: 502 KNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNN 561
KN +M + ++ E+ IL+ H +I+ Y + ++ + +EYV G + +
Sbjct: 57 KNM-----EMEEKVRREIKILRLFMHPHIIRQYEVIETTSDIYVVMEYVKSGELFDYIVE 111
Query: 562 YGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPL 621
G E +NF +QI+ G+ Y H+ ++HRD+K N+L+D + +KI DFG+S +
Sbjct: 112 KGRLQEDEARNFFQQIISGVEYCHRNMVVHRDLKPENLLLDSRCNIKIADFGLSNVM--- 168
Query: 622 NKQQNKRASLQGSVYWMAPEVVK-QVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAI 680
+ + + GS + APEV+ ++ + D+WS G ++ + G PF D + +
Sbjct: 169 -RDGHFLKTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYALLCGTLPFDD-ENIPNL 226
Query: 681 FKIGTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWLNTVL 730
FK I +PS +S EA+ + + +D KR + + Q W T L
Sbjct: 227 FKKIKGGIYTLPSHLSSEARDLIPRMLIVDPVKRITIPEIRQHRWFQTHL 276
>SPAC57A10.02 [D] KOG0588 Serine/threonine protein kinase
Length = 775
Score = 107 bits (266), Expect = 8e-23
Identities = 76/290 (26%), Positives = 128/290 (43%), Gaps = 37/290 (12%)
Query: 439 WLKGARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGN 498
W G +GSG S L + ETG+L VK +
Sbjct: 10 WELGLSLGSGGPNSSRLAKHRETGQLAVVKPIV--------------------------- 42
Query: 499 TAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSM 558
S++ ++ E+ +L+ + H N++ L + +EY+PGG +
Sbjct: 43 ----GWSELTSSQQARIEGELVLLRLIEHPNVLQLIDVISAQEQLFVVVEYMPGGELFDC 98
Query: 559 LNNYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKL 618
+ G F E F QIL GL Y HK +I HRD+K N+ +D G +KI +FG++
Sbjct: 99 MLRKGSFTEQDTAKFLWQILCGLEYCHKLHICHRDLKPENLYLDAHGSIKIGEFGMASIQ 158
Query: 619 SPLNKQQNKRASLQGSVYWMAPEVVK-QVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQM 677
P Q GS ++ +PE++ + +DIWS G + + TGK PF D +
Sbjct: 159 QPGKLLQTS----CGSPHYASPEIIMGRSYDGCASDIWSCGIIFFALLTGKLPFDDDNIR 214
Query: 678 QAIFKIGTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWLN 727
+ K+ E+PS +S +A+ L++ ++D R + + + P+L+
Sbjct: 215 SLLLKVCQGQF-EMPSNISPQAQHLLYRMLDVDSSTRITMEQIREHPFLS 263
>At5g07070 [T] KOG0583 Serine/threonine protein kinase
Length = 456
Score = 107 bits (266), Expect = 8e-23
Identities = 75/285 (26%), Positives = 130/285 (45%), Gaps = 35/285 (12%)
Query: 442 GARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAV 501
G +G G+F VY G + T E +A+K ++ K + G+
Sbjct: 15 GRLLGQGTFAKVYFGRSNHTNESVAIKMID-KDKVMRVGL-------------------- 53
Query: 502 KNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNN 561
+ QI R E+++++ H N+V Y + +EY GG + + +
Sbjct: 54 --SQQIKR--------EISVMRIAKHPNVVELYEVMATKSRIYFVIEYCKGGELFNKVAK 103
Query: 562 YGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPL 621
G E + + Q++ + + H R + HRDIK N+L+D +K++DFG+S L+
Sbjct: 104 -GKLKEDVAWKYFYQLISAVDFCHSRGVYHRDIKPENLLLDDNDNLKVSDFGLS-ALADC 161
Query: 622 NKQQNKRASLQGSVYWMAPEVV-KQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAI 680
+Q + G+ ++APEV+ ++ KADIWS G V+ + G PF D + M+
Sbjct: 162 KRQDGLLHTTCGTPAYVAPEVINRKGYEGTKADIWSCGVVLFVLLAGYLPFHDTNLMEMY 221
Query: 681 FKIGTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPW 725
KIG + PSW + E K L K + ++ R + + + W
Sbjct: 222 RKIGKADF-KCPSWFAPEVKRLLCKMLDPNHETRITIAKIKESSW 265
>At5g01820 [T] KOG0583 Serine/threonine protein kinase
Length = 442
Score = 107 bits (266), Expect = 8e-23
Identities = 79/285 (27%), Positives = 132/285 (45%), Gaps = 35/285 (12%)
Query: 442 GARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAV 501
G +G G+F VY G + TG+ +A+K V SK+ GG N +
Sbjct: 25 GKLVGCGAFAKVYHGRSTATGQSVAIKVV-----------------SKQRLQKGGLNGNI 67
Query: 502 KNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNN 561
Q E+ I+ L H +IV + + +E+ GG + + ++
Sbjct: 68 --------------QREIAIMHRLRHPSIVRLFEVLATKSKIFFVMEFAKGGELFAKVSK 113
Query: 562 YGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPL 621
G F E L + + +Q++ + Y H R I HRD+K N+L+D K +KI+DFG+S L+
Sbjct: 114 -GRFCEDLSRRYFQQLISAVGYCHSRGIFHRDLKPENLLLDEKLDLKISDFGLS-ALTDQ 171
Query: 622 NKQQNKRASLQGSVYWMAPEVV-KQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAI 680
+ +L G+ ++APEV+ K+ K DIWS G ++ + G PF D + M
Sbjct: 172 IRPDGLLHTLCGTPAYVAPEVLAKKGYDGAKIDIWSCGIILFVLNAGYLPFNDHNLMVMY 231
Query: 681 FKIGTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPW 725
KI IP W S + + L + + + + R + ++ +PW
Sbjct: 232 RKIYKGEF-RIPKWTSPDLRRLLTRLLDTNPQTRITIEEIIHDPW 275
>7297240_1 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 326
Score = 107 bits (266), Expect = 8e-23
Identities = 77/265 (29%), Positives = 132/265 (49%), Gaps = 33/265 (12%)
Query: 496 GGNTAVKNTSQIHRKMIDAL-------QHEMNILKELH-------HENIVTYYGS---SQ 538
G N V ++ I AL +H+++I +E H N+ +YG S+
Sbjct: 25 GVNAKVFRAKELDNDRIVALKIQHYDEEHQVSIEEEYRTLRDYCDHPNLPEFYGVYKLSK 84
Query: 539 EGGNLNIF--LEYVPGGSVSSMLNNYGPFD----EPLVKNFTRQILIGLAYLHKRNIIHR 592
G I+ +EY GG+ M+N D E + R+ L++ +++HR
Sbjct: 85 PNGPDEIWFVMEYCAGGTAVDMVNKLLKLDRRMREEHIAYIIRETCRAAIELNRNHVLHR 144
Query: 593 DIKGANILIDIKGGVKITDFGISKKLSPLNKQQNKRASLQGSVYWMAPEVVKQVVTTE-- 650
DI+G NIL+ G VK+ DFG+S++ ++ KR + GS WMAPEVV + + E
Sbjct: 145 DIRGDNILLTKNGRVKLCDFGLSRQ---VDSTLGKRGTCIGSPCWMAPEVVSAMESREPD 201
Query: 651 ---KADIWSVGCVIVEMFTGKHPFPDFSQMQAIFKIGTNIIPEI--PSWVSEEAKAFLFK 705
+AD+W++G +E+ GK PF D +A+F+I N P + P+ S++ F+ +
Sbjct: 202 ITVRADVWALGITTIELADGKPPFADMHPTRAMFQIIRNPPPTLMRPTNWSQQINDFISE 261
Query: 706 SFELDYRKRPSSLGLLQEPWLNTVL 730
S E + RP + +++ P+L ++
Sbjct: 262 SLEKNAENRPMMVEMVEHPFLTELI 286
>SPBC106.10 [T] KOG0616 cAMP-dependent protein kinase catalytic subunit (PKA)
Length = 512
Score = 106 bits (265), Expect = 1e-22
Identities = 78/293 (26%), Positives = 130/293 (43%), Gaps = 48/293 (16%)
Query: 445 IGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKNT 504
+G+GSFG V+L + A+K +E K
Sbjct: 207 LGTGSFGRVHLVQSNHNRLYYAIKVLEKKKI----------------------------- 237
Query: 505 SQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNYGP 564
+ K I+ E IL + H I +G+ Q+ NL + +++ GG + S+L
Sbjct: 238 --VDMKQIEHTCDERYILSRVQHPFITILWGTFQDAKNLFMVMDFAEGGELFSLLRKCHR 295
Query: 565 FDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPLNKQ 624
F E + K + ++++ L YLH I++RD+K N+L+D G +KI DFG +K++S N
Sbjct: 296 FPEKVAKFYAAEVILALDYLHHNQIVYRDLKPENLLLDRFGHLKIVDFGFAKRVSTSN-- 353
Query: 625 QNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAIFKIG 684
+L G+ ++APE++ + AD WS+G +I EM G PF + M K+
Sbjct: 354 ---CCTLCGTPDYLAPEIISLKPYNKAADWWSLGILIFEMLAGYPPFYSENPM----KLY 406
Query: 685 TNIIP---EIPSWVSEEAKAFLFKSFELDYRKR-----PSSLGLLQEPWLNTV 729
NI+ PS+ S + L + D R S+ ++ PW +
Sbjct: 407 ENILEGKVNYPSYFSPASIDLLSHLLQRDITCRYGNLKDGSMDIIMHPWFRDI 459
>HsM7657627 [D] KOG0575 Polo-like serine/threonine protein kinase
Length = 970
Score = 106 bits (265), Expect = 1e-22
Identities = 75/287 (26%), Positives = 132/287 (45%), Gaps = 36/287 (12%)
Query: 442 GARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAV 501
G +G GSF VY + TG +A+K ++ KKA G V
Sbjct: 15 GNLLGKGSFAGVYRAESIHTGLEVAIKMID-----------------KKAMYKAGMVQRV 57
Query: 502 KNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNN 561
KN +IH +L H +I+ Y ++ + + LE G ++ L N
Sbjct: 58 KNEVKIHC--------------QLKHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKN 103
Query: 562 -YGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSP 620
PF E ++F QI+ G+ YLH I+HRD+ +N+L+ +KI DFG++ +
Sbjct: 104 RVKPFSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLA---TQ 160
Query: 621 LNKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAI 680
L K +L G+ +++PE+ + ++D+WS+GC+ + G+ PF + +
Sbjct: 161 LKMPHEKHYTLCGTPNYISPEIATRSAHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTL 220
Query: 681 FKIGTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWLN 727
K+ E+P+++S EAK + + + R S +L P+++
Sbjct: 221 NKV-VLADYEMPTFLSIEAKDLIHQLLRRNPADRLSLSSVLDHPFMS 266
>Hs4759178 [D] KOG0580 Serine/threonine protein kinase
Length = 344
Score = 106 bits (265), Expect = 1e-22
Identities = 74/286 (25%), Positives = 126/286 (43%), Gaps = 39/286 (13%)
Query: 442 GARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAV 501
G +G G FG+VYL ++ ++A+K V
Sbjct: 80 GRPLGKGKFGNVYLAREKKSHFIVALK--------------------------------V 107
Query: 502 KNTSQIHRKMID-ALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLN 560
SQI ++ ++ L+ E+ I LHH NI+ Y + + + LEY P G + L
Sbjct: 108 LFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQ 167
Query: 561 NYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSP 620
FDE ++ L Y H + +IHRDIK N+L+ +KG +KI DFG S
Sbjct: 168 KSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPS 227
Query: 621 LNKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAI 680
L +R ++ G++ ++ PE+++ + EK D+W +G + E+ G PF S +
Sbjct: 228 L-----RRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETY 282
Query: 681 FKIGTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
+I + + P+ V A+ + K + +R + PW+
Sbjct: 283 RRI-VKVDLKFPASVPTGAQDLISKLLRHNPSERLPLAQVSAHPWV 327
>Hs21361433 [D] KOG0575 Polo-like serine/threonine protein kinase
Length = 970
Score = 106 bits (265), Expect = 1e-22
Identities = 73/287 (25%), Positives = 134/287 (46%), Gaps = 36/287 (12%)
Query: 442 GARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAV 501
G +G GSF VY + +G +A+K ++ KKA G
Sbjct: 15 GNLLGKGSFAGVYRAESIHSGLEVAIKMID-----------------KKAMYKAG----- 52
Query: 502 KNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNN 561
M+ +Q+E+ I +L H +I+ Y ++ + + LE G ++ L N
Sbjct: 53 ---------MVQRVQNEVKIHCQLKHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKN 103
Query: 562 -YGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSP 620
PF E ++F QI+ G+ YLH I+HRD+ +N+L+ +KI DFG++ +
Sbjct: 104 RVKPFSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLA---TQ 160
Query: 621 LNKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAI 680
L K +L G+ +++PE+ + ++D+WS+GC+ + G+ PF + +
Sbjct: 161 LKMPHEKHYTLCGTPNYISPEIATRSAHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTL 220
Query: 681 FKIGTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWLN 727
K+ E+P+++S EAK + + + R S +L P+++
Sbjct: 221 NKV-VLADYEMPTFLSIEAKDLIHQLLRRNPADRLSLSSVLDHPFMS 266
>Hs19424132 [D] KOG0591 NIMA (never in mitosis)-related G2-specific
serine/threonine protein kinase
Length = 302
Score = 106 bits (265), Expect = 1e-22
Identities = 67/207 (32%), Positives = 106/207 (50%), Gaps = 14/207 (6%)
Query: 518 EMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNYGP----FDEPLVKNF 573
E+++LK+L+H N++ YY S E LNI LE G +S M+ ++ E V +
Sbjct: 82 EIDLLKQLNHPNVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKY 141
Query: 574 TRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPLNKQQNKRASLQG 633
Q+ L ++H R ++HRDIK AN+ I G VK+ D G+ + S + SL G
Sbjct: 142 FVQLCSALEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFS---SKTTAAHSLVG 198
Query: 634 SVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAIFKIGTNI----IP 689
+ Y+M+PE + + K+DIWS+GC++ EM + PF + ++ + I P
Sbjct: 199 TPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPF--YGDKMNLYSLCKKIEQCDYP 256
Query: 690 EIPS-WVSEEAKAFLFKSFELDYRKRP 715
+PS SEE + + D KRP
Sbjct: 257 PLPSDHYSEELRQLVNMCINPDPEKRP 283
>CE21025 [D] KOG0580 Serine/threonine protein kinase
Length = 326
Score = 106 bits (265), Expect = 1e-22
Identities = 78/287 (27%), Positives = 136/287 (47%), Gaps = 39/287 (13%)
Query: 442 GARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAV 501
G +G G FG+V++ +T ++A+K V K + GV +H
Sbjct: 47 GRPLGKGKFGNVFISREKKTKRIIALK-VLFKTQLLQLGV---------SHQ-------- 88
Query: 502 KNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNN 561
L+ E+ I L H NI+T YG + + + L+Y G + ++L +
Sbjct: 89 -------------LKREIEIQYHLRHPNILTLYGYFHDDKRVFVILDYASRGELFNVLQS 135
Query: 562 YG--PFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLS 619
+E + F RQ+ L Y H + +IHRDIK N+L+D K +K+ DFG S
Sbjct: 136 QPGHKVNEVIAGRFVRQLANALHYCHSKGVIHRDIKPENLLLDSKLNLKLADFGWS---- 191
Query: 620 PLNKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQA 679
+ +KR +L G++ ++APE+V DIW++G ++ EM G PF + + +
Sbjct: 192 -VVADHSKRHTLCGTMDYLAPEMVSNQPHDFNVDIWAIGILLFEMLVGYAPFANQTGDKL 250
Query: 680 IFKIGTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
I +I I IPS V++ A + + + + ++R + ++ PW+
Sbjct: 251 IARIKECKI-YIPSVVTDGAASLINAIIKKEPQERLPLVDIMAHPWI 296
>At4g30960 [T] KOG0583 Serine/threonine protein kinase
Length = 441
Score = 106 bits (265), Expect = 1e-22
Identities = 74/285 (25%), Positives = 133/285 (45%), Gaps = 35/285 (12%)
Query: 442 GARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAV 501
G +G G+F VY N +TG+ +A+K V K V G
Sbjct: 27 GRLLGHGTFAKVYHARNIQTGKSVAMKVVG-KEKVVKVG--------------------- 64
Query: 502 KNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNN 561
M+D ++ E+++++ + H NIV + + +E V GG + + +
Sbjct: 65 ---------MVDQIKREISVMRMVKHPNIVELHEVMASKSKIYFAMELVRGGELFAKVAK 115
Query: 562 YGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPL 621
G E + + + +Q++ + + H R + HRD+K N+L+D +G +K+TDFG+S L
Sbjct: 116 -GRLREDVARVYFQQLISAVDFCHSRGVYHRDLKPENLLLDEEGNLKVTDFGLSAFTEHL 174
Query: 622 NKQQNKRASLQGSVYWMAPEVV-KQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAI 680
KQ + G+ ++APEV+ K+ KAD+WS G ++ + G PF D + +
Sbjct: 175 -KQDGLLHTTCGTPAYVAPEVILKKGYDGAKADLWSCGVILFVLLAGYLPFQDDNLVNMY 233
Query: 681 FKIGTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPW 725
KI + P W+S +A+ + K + + R + ++ PW
Sbjct: 234 RKIYRGDF-KCPGWLSSDARRLVTKLLDPNPNTRITIEKVMDSPW 277
>At1g45160 [TR] KOG0606 Microtubule-associated serine/threonine kinase and
related proteins
Length = 1067
Score = 106 bits (265), Expect = 1e-22
Identities = 82/305 (26%), Positives = 135/305 (43%), Gaps = 65/305 (21%)
Query: 445 IGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKNT 504
I G+FG V+L TG+ A+K +K
Sbjct: 676 ISRGAFGKVFLARKRTTGDFFAIK-------------------------------VLKKL 704
Query: 505 SQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNYGP 564
I + I+ + E NIL + + +V ++ S NL + +EY+ GG + S+L G
Sbjct: 705 DMIRKNDIERILQERNILITVRYPFLVRFFYSFTCRDNLYLVMEYLNGGDLYSLLQKVGC 764
Query: 565 FDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISK-------- 616
DE + + + ++++ L YLH I+HRD+K N+LI G +K+TDFG+SK
Sbjct: 765 LDEEIARIYIAELVLALEYLHSLKIVHRDLKPDNLLIAYNGHIKLTDFGLSKIGLINNTI 824
Query: 617 -------KLSPL---------NKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCV 660
+SP +++ R S G+ ++APE++ AD WS G V
Sbjct: 825 DLSGHESDVSPRTNSHHFQKNQEEERIRHSAVGTPDYLAPEILLGTEHGYAADWWSAGIV 884
Query: 661 IVEMFTGKHPFPDFSQMQAIFKIGTNII------PEIPSWVSEEAKAFLFKSFELDYRKR 714
+ E+ TG PF S+ + IF NI+ P++P +S EA+ + + + KR
Sbjct: 885 LFELLTGIPPF-TASRPEKIF---DNILNGKMPWPDVPGEMSYEAQDLINRLLVHEPEKR 940
Query: 715 PSSLG 719
+ G
Sbjct: 941 LGANG 945
>At1g18350 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 307
Score = 106 bits (265), Expect = 1e-22
Identities = 87/298 (29%), Positives = 137/298 (45%), Gaps = 53/298 (17%)
Query: 445 IGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKNT 504
+G GS G VY + TGE+ A+K V G+ + T
Sbjct: 51 LGRGSSGIVYKVHHKTTGEIYALKSV-------------------------NGDMSPAFT 85
Query: 505 SQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEG--GNLNIFLEYVPGGSVSSMLNNY 562
Q+ R EM IL+ +V G ++ G ++I +EY+ GG++ S+
Sbjct: 86 RQLAR--------EMEILRRTDSPYVVRCQGIFEKPIVGEVSILMEYMDGGNLESL---R 134
Query: 563 GPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPLN 622
G E + F+RQIL GL+YLH I+HRDIK AN+L++ + VKI DFG+SK ++
Sbjct: 135 GAVTEKQLAGFSRQILKGLSYLHSLKIVHRDIKPANLLLNSRNEVKIADFGVSKIIT--- 191
Query: 623 KQQNKRASLQGSVYWMAPEVVKQVVTTEK----ADIWSVGCVIVEMFTGKHPF------P 672
+ + S G+ +M+PE DIWS G +I+E+F G P P
Sbjct: 192 RSLDYCNSYVGTCAYMSPERFDSAAGENSDVYAGDIWSFGVMILELFVGHFPLLPQGQRP 251
Query: 673 DFSQMQAIFKIGTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWLNTVL 730
D++ + + G P P S+E ++F+ + +R ++ LL P+L L
Sbjct: 252 DWATLMCVVCFGEP--PRAPEGCSDEFRSFVDCCLRKESSERWTASQLLGHPFLRESL 307
>CE22045 [RT] KOG0598 Ribosomal protein S6 kinase and related proteins
Length = 580
Score = 106 bits (264), Expect = 1e-22
Identities = 63/188 (33%), Positives = 106/188 (55%), Gaps = 4/188 (2%)
Query: 518 EMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNYGPFDEPLVKNFTRQI 577
E NIL+ + I + Q GG L + LEY+ GG + L G F E + K + +I
Sbjct: 135 ERNILEAVKSPFICDLLYAFQTGGKLYLILEYLSGGELFMHLEREGMFMENVAKFYLSEI 194
Query: 578 LIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPLNKQQNKRASLQGSVYW 637
++ L +LH++ II+RD+K NIL+D G VK+TDFG+ K+ + K + G++ +
Sbjct: 195 VVSLEHLHQQGIIYRDLKPENILLDAYGHVKLTDFGLCKEEI---EGDQKTHTFCGTIEY 251
Query: 638 MAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAIFKIGTNIIPEIPSWVSE 697
MAPE++ + + D WS+G ++ +M TG PF ++ + I KI + +P+++S
Sbjct: 252 MAPEILMRCGHGKAVDWWSLGALMFDMLTGGPPFTAENRRKTIDKILKGRL-TLPAYLSN 310
Query: 698 EAKAFLFK 705
EA+ + K
Sbjct: 311 EARDLIKK 318
>At5g56580 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 356
Score = 106 bits (264), Expect = 1e-22
Identities = 69/209 (33%), Positives = 111/209 (53%), Gaps = 16/209 (7%)
Query: 529 NIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNYGPFDEPLVKNFTRQILIGLAYLH-KR 587
++V Y S G ++ LEY+ GS++ ++ EP + +Q+L+GL YLH +R
Sbjct: 128 HVVVCYHSFYHNGAFSLVLEYMDRGSLADVIRQVKTILEPYLAVVCKQVLLGLVYLHNER 187
Query: 588 NIIHRDIKGANILIDIKGGVKITDFGISKKLSPLNKQQNKRASLQGSVYWMAPEVVKQVV 647
++IHRDIK +N+L++ KG VKI+DFG+S L+ +R + G+ +M+PE +
Sbjct: 188 HVIHRDIKPSNLLVNHKGEVKISDFGVSASLA---SSMGQRDTFVGTYNYMSPERISGST 244
Query: 648 TTEKADIWSVGCVIVEMFTGKHPF---------PDFSQMQAIFKIGTNIIPEIPS-WVSE 697
+DIWS+G ++E G+ P+ P F ++ A I N P PS S
Sbjct: 245 YDYSSDIWSLGMSVLECAIGRFPYLESEDQQNPPSFYELLA--AIVENPPPTAPSDQFSP 302
Query: 698 EAKAFLFKSFELDYRKRPSSLGLLQEPWL 726
E +F+ + D R SSL LL P++
Sbjct: 303 EFCSFVSACIQKDPPARASSLDLLSHPFI 331
>At5g04510 [T] KOG0592 3-phosphoinositide-dependent protein kinase (PDK1)
Length = 488
Score = 106 bits (264), Expect = 1e-22
Identities = 77/300 (25%), Positives = 132/300 (43%), Gaps = 44/300 (14%)
Query: 442 GARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAV 501
G G GS+ V ETG + A+K ++ K I E+K A+
Sbjct: 44 GKIYGVGSYSKVVRAKKKETGTVYALKIMDKK---------FITKENKTAY--------- 85
Query: 502 KNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNN 561
++ E +L +L H I+ Y + Q+ +L + LE GG + +
Sbjct: 86 -------------VKLERIVLDQLEHPGIIKLYFTFQDTSSLYMALESCEGGELFDQITR 132
Query: 562 YGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLS-- 619
G E + +T +++ L Y+H +IHRDIK N+L+ G +KI DFG K +
Sbjct: 133 KGRLSEDEARFYTAEVVDALEYIHSMGLIHRDIKPENLLLTSDGHIKIADFGSVKPMQDS 192
Query: 620 -----PLNKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDF 674
P +K + G+ ++ PEV+ T D+W++GC + +M +G PF D
Sbjct: 193 QITVLPNAASDDKACTFVGTAAYVPPEVLNSSPATFGNDLWALGCTLYQMLSGTSPFKDA 252
Query: 675 SQMQAIFKIGTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSS-----LGLLQEPWLNTV 729
S+ +I I + P+ SE A+ + + + + +RP + + L + P+ N V
Sbjct: 253 SEWLIFQRIIARDI-KFPNHFSEAARDLIDRLLDTEPSRRPGAGSEGYVALKRHPFFNGV 311
>YOR231w [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 508
Score = 105 bits (263), Expect = 2e-22
Identities = 74/248 (29%), Positives = 122/248 (48%), Gaps = 39/248 (15%)
Query: 503 NTSQIHRKMIDALQHEMNILKELHHENIVTYYG--SSQEGGNLNIFLEYVPGGSVSSMLN 560
NT ++K I E+ + E IV YYG + E ++ I +EY+ G S+ ++
Sbjct: 256 NTDPEYQKQIF---RELQFNRSFQSEYIVRYYGMFTDDENSSIYIAMEYMGGRSLDAIYK 312
Query: 561 NY----GPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISK 616
N G E ++ +L GL+YLH++ +IHRDIK NIL++ G VK+ DFG+S
Sbjct: 313 NLLERGGRISEKVLGKIAEAVLRGLSYLHEKKVIHRDIKPQNILLNENGQVKLCDFGVSG 372
Query: 617 KLSPLNKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQ 676
+ + + G+ ++MAPE ++ + +D+WS+G I+E+ GK FP S+
Sbjct: 373 E-----AVNSLATTFTGTSFYMAPERIQGQPYSVTSDVWSLGLTILEVANGK--FPCSSE 425
Query: 677 MQAIFKIGTNIIP-EIPSWV-----------------SEEAKAFLFKSFELDYRKRPSSL 718
K+ NI P E+ W+ S K+F+ + D R+RPS
Sbjct: 426 -----KMAANIAPFELLMWILTFTPELKDEPESNIIWSPSFKSFIDYCLKKDSRERPSPR 480
Query: 719 GLLQEPWL 726
++ PW+
Sbjct: 481 QMINHPWI 488
>Hs4826776 [T] KOG0197 Tyrosine kinases
Length = 1132
Score = 105 bits (263), Expect = 2e-22
Identities = 76/256 (29%), Positives = 120/256 (46%), Gaps = 45/256 (17%)
Query: 444 RIGSGSFGSV----YLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNT 499
++G G+FGSV Y + TGE++AVK+++ S + H
Sbjct: 854 QLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQ---------------HSTEEH------- 891
Query: 500 AVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGG--NLNIFLEYVPGGSVSS 557
+ + E+ ILK L H+NIV Y G G NL + +EY+P GS+
Sbjct: 892 ------------LRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRD 939
Query: 558 MLNNYGP-FDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISK 616
L + D + +T QI G+ YL + IHRD+ NIL++ + VKI DFG++K
Sbjct: 940 YLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTK 999
Query: 617 KLSPLNKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFT----GKHPFP 672
L + + + ++W APE + + + +D+WS G V+ E+FT K P
Sbjct: 1000 VLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPA 1059
Query: 673 DFSQMQAIFKIGTNII 688
+F +M K G I+
Sbjct: 1060 EFMRMIGNDKQGQMIV 1075
Score = 51.6 bits (122), Expect = 4e-06
Identities = 51/233 (21%), Positives = 96/233 (40%), Gaps = 44/233 (18%)
Query: 445 IGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKNT 504
+G G+F ++ G+ E G+ + + E+ +K
Sbjct: 551 LGQGTFTKIFKGVRREVGDYGQLHETEV---------------------------LLKVL 583
Query: 505 SQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNYGP 564
+ HR ++ +++ +L H+++V YG G + E+V GS+ + L
Sbjct: 584 DKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKN 643
Query: 565 FDEPLVK-NFTRQILIGLAYLHKRNIIHRDIKGANILI----DIKGG----VKITDFGIS 615
L K +Q+ + +L + +IH ++ NIL+ D K G +K++D GIS
Sbjct: 644 CINILWKLEVAKQLAWAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGIS 703
Query: 616 KKLSPLNKQQNKRASLQGSVYWMAPEVVKQVVTTEKA-DIWSVGCVIVEMFTG 667
+ P + LQ + W+ PE ++ A D WS G + E+ +G
Sbjct: 704 ITVLP-------KDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSG 749
>Hs4502709 [R] KOG0594 Protein kinase PCTAIRE and related kinases
Length = 297
Score = 105 bits (263), Expect = 2e-22
Identities = 84/324 (25%), Positives = 145/324 (43%), Gaps = 70/324 (21%)
Query: 437 KSWLKGARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGG 496
+ + K +IG G++G VY G + TG+++A+K++ L+ + G
Sbjct: 2 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLE-----------------SEEEGV 44
Query: 497 GNTAVKNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVS 556
+TA++ E+++LKEL H NIV+ + L + E++ +
Sbjct: 45 PSTAIR---------------EISLLKELRHPNIVSLQDVLMQDSRLYLIFEFL-SMDLK 88
Query: 557 SMLNNYGP---FDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFG 613
L++ P D LVK++ QIL G+ + H R ++HRD+K N+LID KG +K+ DFG
Sbjct: 89 KYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFG 148
Query: 614 ISKKLS-PLNKQQNKRASLQGSVYWMAPEV-VKQVVTTEKADIWSVGCVIVEMFTGKHPF 671
+++ P+ ++ +L ++ +PEV + + DIWS+G + E+ T K F
Sbjct: 149 LARAFGIPIRVYTHEVVTL----WYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLF 204
Query: 672 PDFSQMQAIFKI-------GTNIIPEI----------PSW-----------VSEEAKAFL 703
S++ +F+I + PE+ P W + E L
Sbjct: 205 HGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLL 264
Query: 704 FKSFELDYRKRPSSLGLLQEPWLN 727
K D KR S L P+ N
Sbjct: 265 SKMLIYDPAKRISGKMALNHPYFN 288
>Hs14196445 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 476
Score = 105 bits (263), Expect = 2e-22
Identities = 81/294 (27%), Positives = 136/294 (45%), Gaps = 47/294 (15%)
Query: 445 IGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAVKNT 504
+GSG+F V+L TG+L A+K ++ P A +++
Sbjct: 29 LGSGAFSEVFLVKQRLTGKLFALKCIKKSP-------------------------AFRDS 63
Query: 505 SQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNNYGP 564
S L++E+ +LK++ HENIVT + + + ++ V GG + + G
Sbjct: 64 S---------LENEIAVLKKIKHENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGV 114
Query: 565 FDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILI---DIKGGVKITDFGISKKLSPL 621
+ E +Q+L + YLH+ I+HRD+K N+L + + ITDFG+SK
Sbjct: 115 YTEKDASLVIQQVLSAVKYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKM---- 170
Query: 622 NKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAIF 681
+Q ++ G+ ++APEV+ Q ++ D WS+G + + G PF + ++ +
Sbjct: 171 -EQNGIMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFE 229
Query: 682 KIGTNIIP-EIPSW--VSEEAKAFLFKSFELDYRKRPSSLGLLQEPWL--NTVL 730
KI E P W +SE AK F+ E D +R + L PW+ NT L
Sbjct: 230 KIKEGYYEFESPFWDDISESAKDFICHLLEKDPNERYTCEKALSHPWIDGNTAL 283
>Hs13489054 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 400
Score = 105 bits (263), Expect = 2e-22
Identities = 67/201 (33%), Positives = 116/201 (57%), Gaps = 15/201 (7%)
Query: 488 SKKAHSPGGGNTAVKNTSQIHRKMIDALQH----EMNILKELHHENIVTYYGSSQEGGNL 543
+K H P G A K IH ++ A+++ E+ +L E + IV +YG+ G +
Sbjct: 87 TKVQHRPSGLIMARK---LIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEI 143
Query: 544 NIFLEYVPGGSVSSMLNNYGPFDEPLVKNFTRQILIGLAYL-HKRNIIHRDIKGANILID 602
+I +E++ GGS+ +L E ++ + +L GLAYL K I+HRD+K +NIL++
Sbjct: 144 SICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVN 203
Query: 603 IKGGVKITDFGISKKLSPLNKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIV 662
+G +K+ DFG+S +L ++ N S G+ +MAPE ++ + ++DIWS+G +V
Sbjct: 204 SRGEIKLCDFGVSGQL--IDSMAN---SFVGTRSYMAPERLQGTHYSVQSDIWSMGLSLV 258
Query: 663 EMFTGKHPF--PDFSQMQAIF 681
E+ G++P PD +++AIF
Sbjct: 259 ELAVGRYPIPPPDAKELEAIF 279
>At5g45820 [T] KOG0583 Serine/threonine protein kinase
Length = 439
Score = 105 bits (263), Expect = 2e-22
Identities = 71/285 (24%), Positives = 132/285 (45%), Gaps = 35/285 (12%)
Query: 442 GARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAV 501
G +G G+F VY N +TGE +A+K ++ + A
Sbjct: 15 GRLLGQGTFAKVYHARNIKTGESVAIKVIDKQKVAKVG---------------------- 52
Query: 502 KNTSQIHRKMIDALQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLNN 561
+ID ++ E+++++ + H ++V + + +EYV GG + ++
Sbjct: 53 ---------LIDQIKREISVMRLVRHPHVVFLHEVMASKTKIYFAMEYVKGGELFDKVSK 103
Query: 562 YGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSPL 621
G E + + + +Q++ + Y H R + HRD+K N+L+D G +KI+DFG+S L
Sbjct: 104 -GKLKENIARKYFQQLIGAIDYCHSRGVYHRDLKPENLLLDENGDLKISDFGLS-ALRES 161
Query: 622 NKQQNKRASLQGSVYWMAPEVV-KQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAI 680
+Q + G+ ++APEV+ K+ KAD+WS G V+ + G PF + + ++
Sbjct: 162 KQQDGLLHTTCGTPAYVAPEVIGKKGYDGAKADVWSCGVVLYVLLAGFLPFHEQNLVEMY 221
Query: 681 FKIGTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPW 725
KI T + P+W E K L + + + R +++ W
Sbjct: 222 RKI-TKGEFKCPNWFPPEVKKLLSRILDPNPNSRIKIEKIMENSW 265
>At5g39440 [T] KOG0583 Serine/threonine protein kinase
Length = 494
Score = 105 bits (263), Expect = 2e-22
Identities = 76/290 (26%), Positives = 127/290 (43%), Gaps = 38/290 (13%)
Query: 442 GARIGSGSFGSVYLGMNAETGELMAVKQVELKPTAVTAGVVSIADESKKAHSPGGGNTAV 501
G +G GSF V L ++ TG +A+K +
Sbjct: 22 GKTLGHGSFAKVKLALHVATGHKVAIK--------------------------------I 49
Query: 502 KNTSQIHRKMIDA-LQHEMNILKELHHENIVTYYGSSQEGGNLNIFLEYVPGGSVSSMLN 560
N S+I I+ +Q E+ IL+ L H +I+ Y + ++ + +EYV G + +
Sbjct: 50 LNRSKIKNMGIEIKVQREIKILRFLMHPHIIRQYEVIETPNDIYVVMEYVKSGELFDYIV 109
Query: 561 NYGPFDEPLVKNFTRQILIGLAYLHKRNIIHRDIKGANILIDIKGGVKITDFGISKKLSP 620
G E ++ +QI+ G+ Y H+ I+HRD+K N+L+D + +KI DFG+S +
Sbjct: 110 EKGKLQEDEARHLFQQIISGVEYCHRNMIVHRDLKPENVLLDSQCNIKIVDFGLSNVM-- 167
Query: 621 LNKQQNKRASLQGSVYWMAPEVVKQVVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAI 680
+ + GS + APEV+ DIWS G ++ + G PF D +
Sbjct: 168 --HDGHFLKTSCGSPNYAAPEVISGKPYGPDVDIWSCGVILYALLCGTLPFDDENIPNVF 225
Query: 681 FKIGTNIIPEIPSWVSEEAKAFLFKSFELDYRKRPSSLGLLQEPWLNTVL 730
KI + +P+ +S A+ + + +D R S + Q PW N L
Sbjct: 226 EKIKRGMY-TLPNHLSHFARDLIPRMLMVDPTMRISITEIRQHPWFNNHL 274
>At5g27510 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 301
Score = 105 bits (263), Expect = 2e-22
Identities = 77/261 (29%), Positives = 128/261 (48%), Gaps = 19/261 (7%)
Query: 480 GVVSIADESKKAHSPGGG-NTAVKNTSQIHRKMIDALQHEMNILKELHH-ENIVTYYGSS 537
G S D K S G + AVK++ + +L E +IL EL I+ +G+
Sbjct: 14 GAYSFVDLFKYTKSDGSSFHAAVKSSDDEN-----SLLKEFHILSELKGCPRIIQCFGND 68
Query: 538 QEGGN-------LNIFLEYVPGGSVSSMLNNYGPFDEP--LVKNFTRQILIGLAYLHKRN 588
E G + LEY GS+S +NN P ++++FTR IL GL +H
Sbjct: 69 LEEGFDDKGNRVYKLLLEYASEGSLSDFMNNCVDRKLPDLMIRDFTRMILQGLVSIHSHG 128
Query: 589 IIHRDIKGANILIDIKGG---VKITDFGISKKLSPLNKQQNKRASLQGSVYWMAPEVVKQ 645
+H D+K N+L+ G VKI+DFG+S ++ + G++ +M PE +
Sbjct: 129 YVHCDLKPENVLVFPCGDSYEVKISDFGLSLQVGEVPDHWKIEYPFVGTLNYMPPESLHD 188
Query: 646 VVTTEKADIWSVGCVIVEMFTGKHPFPDFSQMQAIFKIGTNIIPEIPSWVSEEAKAFLFK 705
V + D+WS+GC+++EM+ K P+ F ++ + PEIP + +A+AF+ K
Sbjct: 189 GVANKTLDLWSLGCLVLEMYVCKKPWIGFIPEDFVYILSNGNPPEIPESLPCDARAFIQK 248
Query: 706 SFELDYRKRPSSLGLLQEPWL 726
F + ++R ++ LL +L
Sbjct: 249 CFSRNPKERGTASELLSHRFL 269
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.315 0.133 0.375
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 40,994,799
Number of Sequences: 60738
Number of extensions: 1753525
Number of successful extensions: 11174
Number of sequences better than 1.0e-05: 1774
Number of HSP's better than 0.0 without gapping: 595
Number of HSP's successfully gapped in prelim test: 1179
Number of HSP's that attempted gapping in prelim test: 6530
Number of HSP's gapped (non-prelim): 2850
length of query: 730
length of database: 30,389,216
effective HSP length: 114
effective length of query: 616
effective length of database: 23,465,084
effective search space: 14454491744
effective search space used: 14454491744
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)