ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactII3435 suspect: HSP T KOG2199 Signal transduction mechanisms Signal transducing adaptor protein STAM/STAM2
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactII3435 1180382 1178859 -508
(508 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YHL002w [T] KOG2199 Signal transducing adaptor protein STAM/STAM2 199 8e-51
SPBC1734.08 [T] KOG2199 Signal transducing adaptor protein STAM/... 176 7e-44
Hs4507249 [T] KOG2199 Signal transducing adaptor protein STAM/STAM2 98 3e-20
HsM19923337 [T] KOG2199 Signal transducing adaptor protein STAM/... 96 1e-19
Hs21265031 [T] KOG2199 Signal transducing adaptor protein STAM/S... 96 2e-19
CE08579 [T] KOG2199 Signal transducing adaptor protein STAM/STAM2 79 2e-14
7297777 [T] KOG2199 Signal transducing adaptor protein STAM/STAM2 69 2e-11
7294938 [U] KOG1087 Cytosolic sorting protein GGA2/TOM1 68 4e-11
Hs11128045_1 [TU] KOG1029 Endocytic adaptor protein intersectin 64 7e-10
Hs22043851 [T] KOG4225 Sorbin and SH3 domain-containing protein 63 1e-09
YGR136w [T] KOG3601 Adaptor protein GRB2 contains SH2 and SH3 do... 62 2e-09
Hs4504797_1 [TU] KOG1029 Endocytic adaptor protein intersectin 62 2e-09
SPBC119.05c [T] KOG3601 Adaptor protein GRB2 contains SH2 and SH... 62 3e-09
Hs4758476 [T] KOG3601 Adaptor protein GRB2 contains SH2 and SH3 ... 62 3e-09
Hs20544596 [TU] KOG1029 Endocytic adaptor protein intersectin 62 3e-09
Hs4504111 [T] KOG3601 Adaptor protein GRB2 contains SH2 and SH3 ... 61 5e-09
Hs4758528 [TU] KOG1818 Membrane trafficking and cell signaling p... 60 6e-09
Hs4502217 [T] KOG4225 Sorbin and SH3 domain-containing protein 60 8e-09
Hs10947118 [T] KOG4225 Sorbin and SH3 domain-containing protein 60 8e-09
Hs4505573 [F] KOG2070 Guanine nucleotide exchange factor 59 2e-08
Hs22027528 [F] KOG2070 Guanine nucleotide exchange factor 59 2e-08
CE27055 [U] KOG1087 Cytosolic sorting protein GGA2/TOM1 59 2e-08
CE25764 [U] KOG1087 Cytosolic sorting protein GGA2/TOM1 59 2e-08
CE01784 [T] KOG3601 Adaptor protein GRB2 contains SH2 and SH3 do... 59 2e-08
7298751 [TU] KOG1029 Endocytic adaptor protein intersectin 58 3e-08
7303308 [T] KOG3601 Adaptor protein GRB2 contains SH2 and SH3 do... 58 4e-08
Hs5729856 [T] KOG3601 Adaptor protein GRB2 contains SH2 and SH3 ... 57 5e-08
Hs4885637 [U] KOG1087 Cytosolic sorting protein GGA2/TOM1 57 5e-08
Hs11321634 [T] KOG4348 Adaptor protein CMS/SETA 57 7e-08
Hs4506931 [IT] KOG1118 Lysophosphatidic acid acyltransferase end... 57 9e-08
CE29545 [TZ] KOG2546 Abl interactor ABI-1 contains SH3 domain 56 1e-07
Hs20070146 [IT] KOG1118 Lysophosphatidic acid acyltransferase en... 56 1e-07
Hs20550422 [F] KOG2070 Guanine nucleotide exchange factor 55 2e-07
CE18886_2 [F] KOG2070 Guanine nucleotide exchange factor 55 2e-07
Hs4507191 [Z] KOG0040 Ca2+-binding actin-bundling protein (spect... 55 3e-07
Hs7382493 [C] KOG4773 NADPH oxidase 54 4e-07
Hs4505345 [C] KOG4773 NADPH oxidase 54 4e-07
Hs7661670 [S] KOG1843 Uncharacterized conserved protein 54 6e-07
Hs4826844 [Z] KOG0162 Myosin class I heavy chain 54 6e-07
7299844 [TZ] KOG2546 Abl interactor ABI-1 contains SH3 domain 54 6e-07
SPAPJ696.02 [S] KOG1843 Uncharacterized conserved protein 54 7e-07
Hs13994242 [T] KOG4348 Adaptor protein CMS/SETA 54 7e-07
Hs20555436 [TUZ] KOG2856 Adaptor protein PACSIN 53 9e-07
Hs20127477 [TZ] KOG2546 Abl interactor ABI-1 contains SH3 domain 53 9e-07
CE06781 [TU] KOG1818 Membrane trafficking and cell signaling pro... 53 9e-07
7298672 [F] KOG2070 Guanine nucleotide exchange factor 53 9e-07
CE18195 [IT] KOG1118 Lysophosphatidic acid acyltransferase endop... 53 1e-06
YPR154w [T] KOG3601 Adaptor protein GRB2 contains SH2 and SH3 do... 52 2e-06
7301982 [T] KOG4348 Adaptor protein CMS/SETA 52 2e-06
SPAPJ760.02c [Z] KOG3655 Drebrins and related actin binding prot... 52 3e-06
Hs5453754 [T] KOG4226 Adaptor protein NCK/Dock contains SH2 and ... 52 3e-06
7303765 [T] KOG4225 Sorbin and SH3 domain-containing protein 52 3e-06
7294461 [Z] KOG3655 Drebrins and related actin binding proteins 52 3e-06
Hs7108367 [T] KOG2996 Rho guanine nucleotide exchange factor VAV3 51 4e-06
Hs4506929 [IT] KOG1118 Lysophosphatidic acid acyltransferase end... 51 4e-06
Hs5453710 [Z] KOG1702 Nebulin repeat protein 51 5e-06
Hs16418431 [R] KOG4429 Uncharacterized conserved protein contain... 51 5e-06
7302755_2 [S] KOG2995 FOG: SH3 domain 51 5e-06
YFR024c-a [S] KOG1843 Uncharacterized conserved protein 50 6e-06
YFR024c [S] KOG1843 Uncharacterized conserved protein 50 6e-06
Hs4885639 [U] KOG1087 Cytosolic sorting protein GGA2/TOM1 50 6e-06
Hs22060285 [T] KOG4348 Adaptor protein CMS/SETA 50 6e-06
YHR016c [S] KOG1843 Uncharacterized conserved protein 50 8e-06
Hs4507189 [Z] KOG0040 Ca2+-binding actin-bundling protein (spect... 50 8e-06
Hs4505195 [T] KOG0192 Tyrosine kinase specific for activated (GT... 50 8e-06
Hs21361641 [R] KOG0266 WD40 repeat-containing protein 50 8e-06
Hs20336267 [U] KOG1087 Cytosolic sorting protein GGA2/TOM1 50 8e-06
Hs17474837_1 [Z] KOG1654 Microtubule-associated anchor protein i... 50 8e-06
7300664_2 [TUZ] KOG2856 Adaptor protein PACSIN 50 8e-06
>YHL002w [T] KOG2199 Signal transducing adaptor protein STAM/STAM2
Length = 452
Score = 199 bits (506), Expect = 8e-51
Identities = 92/156 (58%), Positives = 127/156 (80%), Gaps = 4/156 (2%)
Query: 222 TVIRKVRAMYDFNSTEQDELSFKKGDLICVVEQVYRDWWRGTLAGSVGIFPLNYVTPVTE 281
TV+R+VRA+YD + E DELSF+KGD+I V+EQVYRDWW+G L G++GIFPLNYVTP+ E
Sbjct: 217 TVVRRVRALYDLTTNEPDELSFRKGDVITVLEQVYRDWWKGALRGNMGIFPLNYVTPIVE 276
Query: 282 PSQQELAAERAKDEQVFAQKDNVDRLQNKLREA---GNA-DITQDQEINDLYGSVSPIRP 337
PS++E+ E+ K+ VF+QK +D+L N L A GN+ ++ QD I D+YGSV+P+RP
Sbjct: 277 PSKEEIEKEKNKEAIVFSQKTTIDQLHNSLNAASKTGNSNEVLQDPHIGDMYGSVTPLRP 336
Query: 338 QISKMLGKYAQKKEDLVSLRQILANAEITYNQLLSR 373
Q+++MLGKYA++KED++SLRQ+LANAE +YNQL+ R
Sbjct: 337 QVTRMLGKYAKEKEDMLSLRQVLANAERSYNQLMDR 372
Score = 175 bits (444), Expect = 1e-43
Identities = 88/151 (58%), Positives = 115/151 (75%), Gaps = 1/151 (0%)
Query: 2 SSHPKVKKAIERATDPGLRVDNWGYLIEVCDLVKVDAEDRGQYAMKIIEERLLKQDANMI 61
SS K++ A+ +ATDP LR DNW Y+++VCDLVK D ED GQ M +IE+RL +QDAN+I
Sbjct: 3 SSAIKIRNALLKATDPKLRSDNWQYILDVCDLVKEDPEDNGQEVMSLIEKRLEQQDANVI 62
Query: 62 LRTLSLVVALAENCGSRLQQAISSKHFTGILYKIVDDSQVHVAVKREVLKVVHQLADSFK 121
LRTLSL V+LAENCGSRL+Q ISSK+FT +LY +++ VH+ +K+ V VV QL+DSFK
Sbjct: 63 LRTLSLTVSLAENCGSRLRQEISSKNFTSLLYALIESHSVHITLKKAVTDVVKQLSDSFK 122
Query: 122 NDPSLKYMHDLESKIKISHPELISEPRVPKK 152
+DPSL+ M DL KIK P L+ +P VP+K
Sbjct: 123 DDPSLRAMGDLYDKIKRKAPYLV-QPNVPEK 152
>SPBC1734.08 [T] KOG2199 Signal transducing adaptor protein STAM/STAM2
Length = 373
Score = 176 bits (446), Expect = 7e-44
Identities = 104/364 (28%), Positives = 177/364 (48%), Gaps = 10/364 (2%)
Query: 7 VKKAIERATDPGLRVDNWGYLIEVCDLVKVDAEDRGQYAMKIIEERLLKQDANMILRTLS 66
++ I +ATD + W +++ CD + + D G+ ++K + +RL +AN+ L L+
Sbjct: 9 IETLILQATDEKNTKEKWDVIMDACDQLSSTSGDVGRNSIKFLNKRLDTANANIQLLALT 68
Query: 67 LVVALAENCGSRLQQAISSKHFTGILYKIVDDSQVHVAVKREVLKVVHQLADSFKNDPSL 126
L A+ +NC + + + ISS+ FT L KI DS H V+ + +V++ A+ K DP++
Sbjct: 69 LTDAIVKNCKTSIVREISSRTFTDSLLKIASDSTTHNRVRSRIAVLVNEWAEIMKKDPNM 128
Query: 127 KYMHDLESKIKISHPELISEPRVPKKKXXXXXXXXXXXXXXXXXXXXXXXXXXKTGSRXX 186
M D+ KI+ + P+ P+K+ ++
Sbjct: 129 SLMQDICEKIRKLDIVDLRAPKKPEKEAMNELELKREEEELQYALALSLSESTAQSNKVE 188
Query: 187 XXXXXXXXXXXXXXXXXXXXKLYPXXXXXXXXXXPTVIRKVRAMYDFNSTEQDELSFKKG 246
K + + +VRA+YDF +TEQ ELSFKKG
Sbjct: 189 NPQSTKDEPLQ---------KTNQRQESNLATSPASTVSRVRALYDFAATEQGELSFKKG 239
Query: 247 DLICVVEQVYRDWWRGTLAGSVGIFPLNYVTPVTEPSQQELAAERAKDEQVFAQKDNVDR 306
D+I V+E VY+DWW+G+ +VGIFP+NYV V EP+ ++ ++QVF +D
Sbjct: 240 DIILVLESVYKDWWKGSCKNAVGIFPVNYVQRVVEPTIEQQRQSAHMEQQVFDALPQIDE 299
Query: 307 LQNKLREAGNADITQDQEINDLYGSVSPIRPQISKMLGKYAQKKEDLVSLRQILANAEIT 366
L + L + D D + Y ++ +RP++ +++ KYA +KE+L+ L + L A
Sbjct: 300 LLDTL-STTSPDAADDDALQGKYHAMIALRPKLVRLIEKYASQKEELMDLNERLLVARRD 358
Query: 367 YNQL 370
Y +L
Sbjct: 359 YEKL 362
>Hs4507249 [T] KOG2199 Signal transducing adaptor protein STAM/STAM2
Length = 540
Score = 97.8 bits (242), Expect = 3e-20
Identities = 84/382 (21%), Positives = 149/382 (38%), Gaps = 38/382 (9%)
Query: 11 IERATDPGLRVDNWGYLIEVCDLVKVDAEDRG-QYAMKIIEERLLKQDANMILRTLSLVV 69
+E+AT ++WG ++++CD KV G + ++ I R+ +D ++ ++ L+L+
Sbjct: 13 VEKATSEMNTAEDWGLILDICD--KVGQSRTGPKDCLRSIMRRVNHKDPHVAMQALTLLG 70
Query: 70 ALAENCGSRLQQAISSKHFTGILYKIVDDSQVHVAVKREVLKVVHQLADSFKNDPSLKYM 129
A NCG + S+ F + +++ V K + L V + D FKNDP L +
Sbjct: 71 ACVSNCGKIFHLEVCSRDFASEVSNVLNKGHPKVCEKLKALMV--EWTDEFKNDPQLSLI 128
Query: 130 HDLESKIK---ISHPELISEPRVPKKKXXXXXXXXXXXXXXXXXXXXXXXXXXKTGSRXX 186
+ +K ++ P + S+ K
Sbjct: 129 SAMIKNLKEQGVTFPAIGSQAAEQAK-------------ASPALVAKDPGTVANKKEEED 175
Query: 187 XXXXXXXXXXXXXXXXXXXXKLYPXXXXXXXXXXPTVIRKVRAMYDFNSTEQDELSFKKG 246
LYP RKVRA+YDF + E +EL+FK G
Sbjct: 176 LAKAIELSLKEQRQQSTTLSTLYPSTSSLLTNHQHEG-RKVRAIYDFEAAEDNELTFKAG 234
Query: 247 DLICVVEQVYRDWWRGTLAGSVGIFPLNYVTPVTEPSQQELAAER--------------- 291
++I V++ +WW+G +G+FP N+VT + + E+
Sbjct: 235 EIITVLDDSDPNWWKGETHQGIGLFPSNFVTADLTAEPEMIKTEKKTVQFSDDVQVETIE 294
Query: 292 AKDEQVFAQKDNVDRLQNKLREAGNADITQD-QEINDLYGSVSPIRPQISKMLGKYAQKK 350
+ E F +D +D+L L+ +D D E+ L + P I + L +K
Sbjct: 295 PEPEPAFIDEDKMDQLLQMLQSTDPSDDQPDLPELLHLEAMCHQMGPLIDEKLEDIDRKH 354
Query: 351 EDLVSLRQILANAEITYNQLLS 372
+L L + A Y +L++
Sbjct: 355 SELSELNVKVMEALSLYTKLMN 376
>HsM19923337 [T] KOG2199 Signal transducing adaptor protein STAM/STAM2
Length = 525
Score = 96.3 bits (238), Expect = 1e-19
Identities = 83/379 (21%), Positives = 159/379 (41%), Gaps = 42/379 (11%)
Query: 11 IERATDPGLRVDNWGYLIEVCDLVKVDAEDRG-QYAMKIIEERLLKQDANMILRTLSLVV 69
+E+AT+ ++W ++++CD KV + G + +K I +R+ + ++ L+ L+L+
Sbjct: 13 VEKATNEYNTTEDWSLIMDICD--KVGSTPNGAKDCLKAIMKRVNHKVPHVALQALTLLG 70
Query: 70 ALAENCGSRLQQAISSKHFTGILYKIVDDSQVHVAVKREVLKVVHQLADSFKNDPSLKYM 129
A NCG + + S+ F + ++ + + H V ++ ++ + ++ F+ DP
Sbjct: 71 ACVANCGKIFRLGVCSRDFATEVRAVIKN-KAHPKVCEKLKSLMVEWSEEFQKDPQFSL- 128
Query: 130 HDLESKIKISHPELISEPRVPKKKXXXXXXXXXXXXXXXXXXXXXXXXXXKTGSRXXXXX 189
+ + IK E I+ P + K
Sbjct: 129 --ISATIKSMKEEGITFPPAGSQ--------------TVSAAAKNGTSSNKNKEDEDIAK 172
Query: 190 XXXXXXXXXXXXXXXXXKLYPXXXXXXXXXXPTVIRKVRAMYDFNSTEQDELSFKKGDLI 249
LYP V RKVRA+YDF + E +EL+FK G++I
Sbjct: 173 AIELSLQEQKQQHTETKSLYPSSEIQLNNK---VARKVRALYDFEAVEDNELTFKHGEII 229
Query: 250 CVVEQVYRDWWRGTLAGSVGIFPLNYVTP---------------VTEPSQQELAAERAKD 294
V++ +WW+G +G+FP ++VT V + +E+ ++++
Sbjct: 230 IVLDDSDANWWKGENHRGIGLFPSDFVTTNLNIETEVAAVDKLNVIDDDVEEI--KKSEP 287
Query: 295 EQVFAQKDNVDRLQNKLREAGNADITQD-QEINDLYGSVSPIRPQISKMLGKYAQKKEDL 353
E V+ +D +DR L+ D D Q++ DL + P I + L + +K +L
Sbjct: 288 EPVYIDEDKMDRALQVLQSIDPTDSKPDSQDLLDLEDICQQMGPMIDEKLEEIDRKHSEL 347
Query: 354 VSLRQILANAEITYNQLLS 372
L + A YN+L++
Sbjct: 348 SELNVKVLEALELYNKLVN 366
>Hs21265031 [T] KOG2199 Signal transducing adaptor protein STAM/STAM2
Length = 525
Score = 95.5 bits (236), Expect = 2e-19
Identities = 83/379 (21%), Positives = 158/379 (40%), Gaps = 42/379 (11%)
Query: 11 IERATDPGLRVDNWGYLIEVCDLVKVDAEDRG-QYAMKIIEERLLKQDANMILRTLSLVV 69
+E+AT+ ++W ++++CD KV + G + +K I +R+ + ++ L+ L+L+
Sbjct: 13 VEKATNEYNTTEDWSLIMDICD--KVGSTPNGAKDCLKAIMKRVNHKVPHVALQALTLLG 70
Query: 70 ALAENCGSRLQQAISSKHFTGILYKIVDDSQVHVAVKREVLKVVHQLADSFKNDPSLKYM 129
A NCG + S+ F + ++ + + H V ++ ++ + ++ F+ DP
Sbjct: 71 ACVANCGKIFHLEVCSRDFATEVRAVIKN-KAHPKVCEKLKSLMVEWSEEFQKDPQFSL- 128
Query: 130 HDLESKIKISHPELISEPRVPKKKXXXXXXXXXXXXXXXXXXXXXXXXXXKTGSRXXXXX 189
+ + IK E I+ P + K
Sbjct: 129 --ISATIKSMKEEGITFPPAGSQ--------------TVSAAAKNGTSSNKNKEDEDIAK 172
Query: 190 XXXXXXXXXXXXXXXXXKLYPXXXXXXXXXXPTVIRKVRAMYDFNSTEQDELSFKKGDLI 249
LYP V RKVRA+YDF + E +EL+FK G++I
Sbjct: 173 AIELSLQEQKQQHTETKSLYPSSEIQLNNK---VARKVRALYDFEAVEDNELTFKHGEII 229
Query: 250 CVVEQVYRDWWRGTLAGSVGIFPLNYVTP---------------VTEPSQQELAAERAKD 294
V++ +WW+G +G+FP ++VT V + +E+ ++++
Sbjct: 230 IVLDDSDANWWKGENHRGIGLFPSDFVTTNLNIETEVAAVDKLNVIDDDVEEI--KKSEP 287
Query: 295 EQVFAQKDNVDRLQNKLREAGNADITQD-QEINDLYGSVSPIRPQISKMLGKYAQKKEDL 353
E V+ +D +DR L+ D D Q++ DL + P I + L + +K +L
Sbjct: 288 EPVYIDEDKMDRALQVLQSIDPTDSKPDSQDLLDLEDICQQMGPMIDEKLEEIDRKHSEL 347
Query: 354 VSLRQILANAEITYNQLLS 372
L + A YN+L++
Sbjct: 348 SELNVKVLEALELYNKLVN 366
>CE08579 [T] KOG2199 Signal transducing adaptor protein STAM/STAM2
Length = 449
Score = 79.0 bits (193), Expect = 2e-14
Identities = 59/265 (22%), Positives = 101/265 (37%), Gaps = 8/265 (3%)
Query: 13 RATDPGLRVDNWGYLIEVCDLVKVDAEDRGQYAMKIIEERLLKQDANMILRTLSLVVALA 72
+ T P + V+NW ++ CD++ D E + +K + +RL +D +++L +S++ +
Sbjct: 10 KITAPTITVENWEGILAFCDMINNDFEG-SKTGIKSLRKRLNNRDPHVVLLAISVLDSCW 68
Query: 73 ENCGSRLQQAISSKHFTGILYKIVDDSQVHVAVKREVLKVVHQLADSFKNDPSLKYMHDL 132
NC R ++ +SS F L + SQ VA K L V + K + SL + L
Sbjct: 69 ANCEERFRKEVSSAQFINELKALCTSSQRQVAEKMR-LTVQKWVDTECKTEQSLSLIVTL 127
Query: 133 ESKIKISHPELISEPRVPKKKXXXXXXXXXXXXXXXXXXXXXXXXXXKTGSRXXXXXXXX 192
+ + + PK K +
Sbjct: 128 HKNLVADGYSFVVDD--PKSKTKAIDAKFANDPNYVGSAQEEEAIAKAIAASLADAEKQE 185
Query: 193 XXXXXXXXXXXXXXKLYPXXXXXXXXXXPTVIRKVRAMYDFNSTEQDELSFKKGDLICVV 252
P + VRA+YDF + E +ELSF GD+I +
Sbjct: 186 KAKKSTSTMYPSAKASSPAVQTNSNIPE----KNVRALYDFEAAESNELSFVAGDIITIT 241
Query: 253 EQVYRDWWRGTLAGSVGIFPLNYVT 277
++ WW G + G+FP ++VT
Sbjct: 242 DESNPHWWTGRIGTQQGLFPSSFVT 266
>7297777 [T] KOG2199 Signal transducing adaptor protein STAM/STAM2
Length = 689
Score = 68.9 bits (167), Expect = 2e-11
Identities = 64/243 (26%), Positives = 94/243 (38%), Gaps = 39/243 (16%)
Query: 225 RKVRAMYDFNSTEQDELSFKKGDLICVVEQVYRDWWRGTLAGSVGIFPLNYVT------- 277
RKVRA+YDF + E++EL+F G++I V++ +WW+G G+FP N+VT
Sbjct: 235 RKVRALYDFEAAEENELTFFAGEIIHVLDDSDPNWWKGYNQRGEGLFPSNFVTADLSVDP 294
Query: 278 ----------PVTEPSQQEL------------AAERAKDEQVFAQKDNVDRLQNKLREAG 315
Q+EL AA A + V + +DRL + L EA
Sbjct: 295 ERLDINQQHKSAAAAGQRELDSAAALQQKTEAAAAAAAAQPVEIDESKIDRLLHLLHEAN 354
Query: 316 NADITQD-QEINDLYGSVSPIRPQISKMLGKYAQKKEDLVSLRQILANAEITYNQLL--- 371
D +QD E+ L V + P I L + +K L L L +A Y+ L+
Sbjct: 355 PEDPSQDSDEMLQLEQEVHQMGPLIDAELERVDRKHAQLTQLSSDLVDAINLYHTLMRDD 414
Query: 372 -SRXXXXXXXXXXXXXXXXXXXXXXXXQSPMSPTAQYTSPTNTQTQMNG-----IPNPPY 425
+ +P P A P M+ +PNPP
Sbjct: 415 RAAAGHFAAAAGGFMPGLAGFPGAALYGAPGYPAAGGFPPAQNYPGMHSMPYGPVPNPPT 474
Query: 426 SYP 428
S P
Sbjct: 475 SAP 477
Score = 58.9 bits (141), Expect = 2e-08
Identities = 35/128 (27%), Positives = 71/128 (55%), Gaps = 4/128 (3%)
Query: 11 IERATDPGLRVDNWGYLIEVCDLVKVDAEDRGQYAMKIIEERLLKQDANMILRTLSLVVA 70
+E+AT DNW +++VCD V + + +K + R+ D +++++ ++L+ A
Sbjct: 14 VEKATSETNTNDNWSLILDVCDKVTTNPR-LAKDCLKAVMRRMGHTDPHVVMQAITLLDA 72
Query: 71 LAENCGSRLQQAISSKHFTGILYKIVDDSQVHVAVK-REVLKVVHQLADSFKNDPSLKYM 129
L+ NCG L ++S+ F +++ +Q V++K R+VLK + + +KND L +
Sbjct: 73 LSNNCGKPLHLEVASRDFETEFRRLLAKAQPKVSLKMRQVLK--NWAENDYKNDRELDLI 130
Query: 130 HDLESKIK 137
L +K++
Sbjct: 131 PALYAKLR 138
>7294938 [U] KOG1087 Cytosolic sorting protein GGA2/TOM1
Length = 543
Score = 67.8 bits (164), Expect = 4e-11
Identities = 38/135 (28%), Positives = 74/135 (54%), Gaps = 5/135 (3%)
Query: 7 VKKAIERATDPGLRVDNWGYLIEVCDLVKVDAEDRGQYAMKIIEERLLK---QDANMILR 63
V + IE ATD L +NW +E+CD++ ++ D + AM+ I +RL + ++ +++
Sbjct: 18 VGQRIEAATDANLASENWAANMEICDMIN-ESSDTARDAMRAIRKRLSQNAGKNNQVVMY 76
Query: 64 TLSLVVALAENCGSRLQQAISSKHFTGILYKIV-DDSQVHVAVKREVLKVVHQLADSFKN 122
TL+++ +NCG ++ K F L K++ + A++ +VL ++ AD+FKN
Sbjct: 77 TLTVLETCVKNCGKAFHVLVAQKDFINELVKLIGPKNDPPAAMQEKVLSLIQIWADAFKN 136
Query: 123 DPSLKYMHDLESKIK 137
P L + + ++K
Sbjct: 137 QPDLNGVTQMYMELK 151
>Hs11128045_1 [TU] KOG1029 Endocytic adaptor protein intersectin
Length = 1177
Score = 63.5 bits (153), Expect = 7e-10
Identities = 31/62 (50%), Positives = 42/62 (67%), Gaps = 2/62 (3%)
Query: 226 KVRAMYDFNSTEQDELSFKKGDLICVVEQVYRDWWRGTLAGSVGIFPLNYV--TPVTEPS 283
+V AMYD+ + +DELSF KG LI V+ + DWW+G + G G+FP NYV T ++PS
Sbjct: 1115 QVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPS 1174
Query: 284 QQ 285
QQ
Sbjct: 1175 QQ 1176
>Hs22043851 [T] KOG4225 Sorbin and SH3 domain-containing protein
Length = 790
Score = 62.8 bits (151), Expect = 1e-09
Identities = 28/52 (53%), Positives = 34/52 (64%)
Query: 225 RKVRAMYDFNSTEQDELSFKKGDLICVVEQVYRDWWRGTLAGSVGIFPLNYV 276
RK +A+YDF +DELSFK GD+I +E V DW G L G GIFP NY+
Sbjct: 733 RKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYI 784
Score = 54.7 bits (130), Expect = 3e-07
Identities = 23/53 (43%), Positives = 36/53 (67%)
Query: 229 AMYDFNSTEQDELSFKKGDLICVVEQVYRDWWRGTLAGSVGIFPLNYVTPVTE 281
A +++ ++DELSF +G++I + E V +W RG + G GIFPLN+V PV +
Sbjct: 578 ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVED 630
Score = 51.2 bits (121), Expect = 4e-06
Identities = 36/103 (34%), Positives = 56/103 (53%), Gaps = 9/103 (8%)
Query: 229 AMYDFNSTEQDELSFKKGDLICVVEQVYRDWWRGTLAGSVGIFPLNYVTPVTEPSQQELA 288
A++ F + D+LSFK+GD I ++E++ DW RG L GIFP +V P ++ LA
Sbjct: 668 ALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPAEAKSMLA 727
Query: 289 ----AERAKDEQVFAQKDNVDRLQNKLREAGNADITQDQEIND 327
+AK F + +N D L K AG+ IT+ + ++D
Sbjct: 728 IVPKGRKAKALYDF-RGENEDELSFK---AGDI-ITELESVDD 765
>YGR136w [T] KOG3601 Adaptor protein GRB2 contains SH2 and SH3 domains
Length = 241
Score = 62.0 bits (149), Expect = 2e-09
Identities = 30/71 (42%), Positives = 40/71 (56%)
Query: 227 VRAMYDFNSTEQDELSFKKGDLICVVEQVYRDWWRGTLAGSVGIFPLNYVTPVTEPSQQE 286
V A+YDF + + +LS K GD I V+E++ DW+RG +GIFP NYV P S
Sbjct: 58 VEALYDFEAQQDGDLSLKTGDKIQVLEKISPDWYRGKSNNKIGIFPANYVKPAFTRSASP 117
Query: 287 LAAERAKDEQV 297
+AE A V
Sbjct: 118 KSAEAASSSTV 128
>Hs4504797_1 [TU] KOG1029 Endocytic adaptor protein intersectin
Length = 1221
Score = 62.0 bits (149), Expect = 2e-09
Identities = 29/62 (46%), Positives = 40/62 (63%), Gaps = 2/62 (3%)
Query: 226 KVRAMYDFNSTEQDELSFKKGDLICVVEQVYRDWWRGTLAGSVGIFPLNYVTPVT--EPS 283
+V MYD+ + DEL+F KG +I V+ + DWW+G + G VG+FP NYV T +PS
Sbjct: 1159 QVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVKLTTDMDPS 1218
Query: 284 QQ 285
QQ
Sbjct: 1219 QQ 1220
Score = 53.5 bits (127), Expect = 7e-07
Identities = 23/48 (47%), Positives = 34/48 (69%), Gaps = 1/48 (2%)
Query: 229 AMYDFNSTEQDELSFKKGDLICVVEQVYRDWWRGTLAGSVGIFPLNYV 276
AMY + S+EQ +L+F++GD+I V ++ DWW GT+ G+FP NYV
Sbjct: 1009 AMYTYESSEQGDLTFQQGDVILVTKKD-GDWWTGTVGDKAGVFPSNYV 1055
>SPBC119.05c [T] KOG3601 Adaptor protein GRB2 contains SH2 and SH3 domains
Length = 296
Score = 61.6 bits (148), Expect = 3e-09
Identities = 27/53 (50%), Positives = 34/53 (63%)
Query: 224 IRKVRAMYDFNSTEQDELSFKKGDLICVVEQVYRDWWRGTLAGSVGIFPLNYV 276
+ +V AMYDF + +L F G++I V+E V DWWRG L G GIFP NYV
Sbjct: 142 VERVLAMYDFPGPDAGDLGFHAGEVIIVLEHVNNDWWRGELNGKEGIFPSNYV 194
>Hs4758476 [T] KOG3601 Adaptor protein GRB2 contains SH2 and SH3 domains
Length = 330
Score = 61.6 bits (148), Expect = 3e-09
Identities = 25/57 (43%), Positives = 36/57 (62%)
Query: 224 IRKVRAMYDFNSTEQDELSFKKGDLICVVEQVYRDWWRGTLAGSVGIFPLNYVTPVT 280
+R RA+YDF + E DEL F G+++ V++ WW G L +G+FP NYV P+T
Sbjct: 273 VRWARALYDFEALEDDELGFHSGEVVEVLDSSNPSWWTGRLHNKLGLFPANYVAPMT 329
>Hs20544596 [TU] KOG1029 Endocytic adaptor protein intersectin
Length = 223
Score = 61.6 bits (148), Expect = 3e-09
Identities = 28/62 (45%), Positives = 40/62 (64%), Gaps = 2/62 (3%)
Query: 226 KVRAMYDFNSTEQDELSFKKGDLICVVEQVYRDWWRGTLAGSVGIFPLNYVTPVT--EPS 283
+V MYD+ + DEL+F KG +I ++ + DWW+G + G VG+FP NYV T +PS
Sbjct: 162 QVIGMYDYTAQNDDELAFNKGQIINILNKEDPDWWKGEVNGQVGLFPSNYVKLTTDMDPS 221
Query: 284 QQ 285
QQ
Sbjct: 222 QQ 223
>Hs4504111 [T] KOG3601 Adaptor protein GRB2 contains SH2 and SH3 domains
Length = 217
Score = 60.8 bits (146), Expect = 5e-09
Identities = 25/53 (47%), Positives = 36/53 (67%)
Query: 227 VRAMYDFNSTEQDELSFKKGDLICVVEQVYRDWWRGTLAGSVGIFPLNYVTPV 279
V+A++DF+ E EL F++GD I V++ +WW+G G G+FP NYVTPV
Sbjct: 161 VQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPV 213
>Hs4758528 [TU] KOG1818 Membrane trafficking and cell signaling protein HRS
contains VHS and FYVE domains
Length = 777
Score = 60.5 bits (145), Expect = 6e-09
Identities = 29/131 (22%), Positives = 75/131 (57%), Gaps = 2/131 (1%)
Query: 8 KKAIERATDPGLRVDNWGYLIEVCDLVKVDAEDRGQYAMKIIEERLLKQDANMILRTLSL 67
++ +++AT L +W ++++CDL++ + + +YA+ I++++ ++ ++ L L +
Sbjct: 9 ERLLDKATSQLLLETDWESILQICDLIR-QGDTQAKYAVNSIKKKVNDKNPHVALYALEV 67
Query: 68 VVALAENCGSRLQQAISSKHFTGILYKIVDDSQVHVAVKREVLKVVHQLADSFKNDPSLK 127
+ ++ +NCG + +++K L ++ QV V V+ ++L ++ A +F+N+P K
Sbjct: 68 MESVVKNCGQTVHDEVANKQTMEELKDLL-KRQVEVNVRNKILYLIQAWAHAFRNEPKYK 126
Query: 128 YMHDLESKIKI 138
+ D +K+
Sbjct: 127 VVQDTYQIMKV 137
>Hs4502217 [T] KOG4225 Sorbin and SH3 domain-containing protein
Length = 666
Score = 60.1 bits (144), Expect = 8e-09
Identities = 25/61 (40%), Positives = 41/61 (66%)
Query: 228 RAMYDFNSTEQDELSFKKGDLICVVEQVYRDWWRGTLAGSVGIFPLNYVTPVTEPSQQEL 287
+A+YDF + ELSFKKGD + ++ ++ ++W+ G G VGIFP++YV +T P + +
Sbjct: 435 KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQP 494
Query: 288 A 288
A
Sbjct: 495 A 495
>Hs10947118 [T] KOG4225 Sorbin and SH3 domain-containing protein
Length = 1100
Score = 60.1 bits (144), Expect = 8e-09
Identities = 25/61 (40%), Positives = 41/61 (66%)
Query: 228 RAMYDFNSTEQDELSFKKGDLICVVEQVYRDWWRGTLAGSVGIFPLNYVTPVTEPSQQEL 287
+A+YDF + ELSFKKGD + ++ ++ ++W+ G G VGIFP++YV +T P + +
Sbjct: 869 KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQP 928
Query: 288 A 288
A
Sbjct: 929 A 929
>Hs4505573 [F] KOG2070 Guanine nucleotide exchange factor
Length = 646
Score = 58.9 bits (141), Expect = 2e-08
Identities = 28/53 (52%), Positives = 32/53 (59%)
Query: 227 VRAMYDFNSTEQDELSFKKGDLICVVEQVYRDWWRGTLAGSVGIFPLNYVTPV 279
VRA ++F T +DELSF KGD+I V WW GTL G G FP NYV V
Sbjct: 11 VRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREV 63
>Hs22027528 [F] KOG2070 Guanine nucleotide exchange factor
Length = 782
Score = 58.9 bits (141), Expect = 2e-08
Identities = 28/53 (52%), Positives = 32/53 (59%)
Query: 227 VRAMYDFNSTEQDELSFKKGDLICVVEQVYRDWWRGTLAGSVGIFPLNYVTPV 279
VRA ++F T +DELSF KGD+I V WW GTL G G FP NYV V
Sbjct: 168 VRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREV 220
>CE27055 [U] KOG1087 Cytosolic sorting protein GGA2/TOM1
Length = 403
Score = 58.5 bits (140), Expect = 2e-08
Identities = 40/141 (28%), Positives = 75/141 (52%), Gaps = 16/141 (11%)
Query: 7 VKKAIERATDPGL-RVDNWGYLIEVCDLVKVDAEDRGQYAMKIIEERL---LKQDANMIL 62
V + IE ATD L +NWG +E+CD + ED + A++ +++RL + ++ +++
Sbjct: 39 VGRKIELATDANLLATENWGLNMEICDFIN-GTEDGPRDAVRALKKRLHNAMSKNNAVVM 97
Query: 63 RTLSLVVALAENCGSRLQQAISSKHFTGILYKIV----DDSQVHVAVKREVLKVVHQLAD 118
TL+++ +NC + +K F L K++ D Q+ ++ VL ++ AD
Sbjct: 98 YTLTVLETAVKNCNHHFHVLVCNKDFVQDLIKLIGPKFDAPQI---IQERVLSLIQAWAD 154
Query: 119 SFKNDPSL----KYMHDLESK 135
+F+ DP+L + DL+SK
Sbjct: 155 AFRGDPTLAGVVQSYDDLKSK 175
>CE25764 [U] KOG1087 Cytosolic sorting protein GGA2/TOM1
Length = 437
Score = 58.5 bits (140), Expect = 2e-08
Identities = 40/141 (28%), Positives = 75/141 (52%), Gaps = 16/141 (11%)
Query: 7 VKKAIERATDPGL-RVDNWGYLIEVCDLVKVDAEDRGQYAMKIIEERL---LKQDANMIL 62
V + IE ATD L +NWG +E+CD + ED + A++ +++RL + ++ +++
Sbjct: 39 VGRKIELATDANLLATENWGLNMEICDFIN-GTEDGPRDAVRALKKRLHNAMSKNNAVVM 97
Query: 63 RTLSLVVALAENCGSRLQQAISSKHFTGILYKIV----DDSQVHVAVKREVLKVVHQLAD 118
TL+++ +NC + +K F L K++ D Q+ ++ VL ++ AD
Sbjct: 98 YTLTVLETAVKNCNHHFHVLVCNKDFVQDLIKLIGPKFDAPQI---IQERVLSLIQAWAD 154
Query: 119 SFKNDPSL----KYMHDLESK 135
+F+ DP+L + DL+SK
Sbjct: 155 AFRGDPTLAGVVQSYDDLKSK 175
>CE01784 [T] KOG3601 Adaptor protein GRB2 contains SH2 and SH3 domains
Length = 228
Score = 58.5 bits (140), Expect = 2e-08
Identities = 25/52 (48%), Positives = 35/52 (67%)
Query: 227 VRAMYDFNSTEQDELSFKKGDLICVVEQVYRDWWRGTLAGSVGIFPLNYVTP 278
V+A++DFN E EL+FK+GD+I ++ + +WW G L GIFP NYV P
Sbjct: 159 VQALFDFNPQESGELAFKRGDVITLINKDDPNWWEGQLNNRRGIFPSNYVCP 210
>7298751 [TU] KOG1029 Endocytic adaptor protein intersectin
Length = 1097
Score = 58.2 bits (139), Expect = 3e-08
Identities = 26/56 (46%), Positives = 36/56 (63%)
Query: 223 VIRKVRAMYDFNSTEQDELSFKKGDLICVVEQVYRDWWRGTLAGSVGIFPLNYVTP 278
++ KV A+Y + + DELSF K D+I V+ + +WWRG L G G+FP NYV P
Sbjct: 1026 ILDKVIALYPYKAQNDDELSFDKDDIISVLGRDEPEWWRGELNGLSGLFPSNYVGP 1081
>7303308 [T] KOG3601 Adaptor protein GRB2 contains SH2 and SH3 domains
Length = 211
Score = 57.8 bits (138), Expect = 4e-08
Identities = 24/52 (46%), Positives = 33/52 (63%)
Query: 227 VRAMYDFNSTEQDELSFKKGDLICVVEQVYRDWWRGTLAGSVGIFPLNYVTP 278
V+A+YDF E EL F++GD+I V ++ +WW G + GIFP YVTP
Sbjct: 157 VQALYDFVPQESGELDFRRGDVITVTDRSDENWWNGEIGNRKGIFPATYVTP 208
>Hs5729856 [T] KOG3601 Adaptor protein GRB2 contains SH2 and SH3 domains
Length = 217
Score = 57.4 bits (137), Expect = 5e-08
Identities = 24/52 (46%), Positives = 36/52 (69%)
Query: 228 RAMYDFNSTEQDELSFKKGDLICVVEQVYRDWWRGTLAGSVGIFPLNYVTPV 279
+A +DF++ + +LSF++GD+I V+E+ WWRG G VG FP +YV PV
Sbjct: 164 QAQFDFSAQDPSQLSFRRGDIIEVLERPDPHWWRGRSCGRVGFFPRSYVQPV 215
>Hs4885637 [U] KOG1087 Cytosolic sorting protein GGA2/TOM1
Length = 492
Score = 57.4 bits (137), Expect = 5e-08
Identities = 30/123 (24%), Positives = 72/123 (58%), Gaps = 4/123 (3%)
Query: 7 VKKAIERATDPGLRVDNWGYLIEVCDLVKVDAEDRGQYAMKIIEERLL-KQDANMILRTL 65
V + IE+ATD L+ ++W +E+CD++ + E+ + A++ +++R++ ++ + ++ L
Sbjct: 13 VGQRIEKATDGSLQSEDWALNMEICDIIN-ETEEGPKDALRAVKKRIVGNKNFHEVMLAL 71
Query: 66 SLVVALAENCGSRLQQAISSKHF--TGILYKIVDDSQVHVAVKREVLKVVHQLADSFKND 123
+++ +NCG R ++S+ F + ++ I+ + V +VL ++ AD+F++
Sbjct: 72 TVLETCVKNCGHRFHVLVASQDFVESVLVRTILPKNNPPTIVHDKVLNLIQSWADAFRSS 131
Query: 124 PSL 126
P L
Sbjct: 132 PDL 134
>Hs11321634 [T] KOG4348 Adaptor protein CMS/SETA
Length = 639
Score = 57.0 bits (136), Expect = 7e-08
Identities = 28/104 (26%), Positives = 50/104 (47%)
Query: 225 RKVRAMYDFNSTEQDELSFKKGDLICVVEQVYRDWWRGTLAGSVGIFPLNYVTPVTEPSQ 284
R+ + ++++ +DEL K GD+I + E+V WW GTL +G+FP N+V +
Sbjct: 111 RQCKVLFEYIPQNEDELELKVGDIIDINEEVEEGWWSGTLNNKLGLFPSNFVKELEVTDD 170
Query: 285 QELAAERAKDEQVFAQKDNVDRLQNKLREAGNADITQDQEINDL 328
E + E V A + + E + +TQ ++I +
Sbjct: 171 GETHEAQDDSETVLAGPTSPIPSLGNVSETASGSVTQPKKIRGI 214
>Hs4506931 [IT] KOG1118 Lysophosphatidic acid acyltransferase endophilin/SH3GL
involved in synaptic vesicle formation
Length = 352
Score = 56.6 bits (135), Expect = 9e-08
Identities = 23/49 (46%), Positives = 32/49 (64%)
Query: 228 RAMYDFNSTEQDELSFKKGDLICVVEQVYRDWWRGTLAGSVGIFPLNYV 276
RA+YDF + EL FK+GD+I + Q+ +W+ G L G G FP+NYV
Sbjct: 296 RALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHSGFFPINYV 344
>CE29545 [TZ] KOG2546 Abl interactor ABI-1 contains SH3 domain
Length = 469
Score = 56.2 bits (134), Expect = 1e-07
Identities = 22/56 (39%), Positives = 39/56 (69%)
Query: 224 IRKVRAMYDFNSTEQDELSFKKGDLICVVEQVYRDWWRGTLAGSVGIFPLNYVTPV 279
+ KVR +YD+++ ++DEL+ ++ ++ V+++ DW+ G L G G+FP NYV PV
Sbjct: 414 LEKVRVLYDYDAAKEDELTLRENAIVYVLKKNDDDWYEGVLDGVTGLFPGNYVVPV 469
>Hs20070146 [IT] KOG1118 Lysophosphatidic acid acyltransferase endophilin/SH3GL
involved in synaptic vesicle formation
Length = 355
Score = 55.8 bits (133), Expect = 1e-07
Identities = 22/49 (44%), Positives = 31/49 (62%)
Query: 228 RAMYDFNSTEQDELSFKKGDLICVVEQVYRDWWRGTLAGSVGIFPLNYV 276
R +YDF Q EL FK+GD+I + Q+ +W+ G + G G FP+NYV
Sbjct: 299 RGLYDFEPENQGELGFKEGDIITLTNQIDENWYEGMIHGESGFFPINYV 347
>Hs20550422 [F] KOG2070 Guanine nucleotide exchange factor
Length = 776
Score = 55.5 bits (132), Expect = 2e-07
Identities = 28/67 (41%), Positives = 39/67 (57%), Gaps = 1/67 (1%)
Query: 227 VRAMYDFNSTEQDELSFKKGDLICVVEQVYRDWWRGTLAGSVGIFPLNYVTPVTEPSQQE 286
V+A ++F T +DELS KGD+I V WW GTL G G FP NYV + + S++
Sbjct: 165 VKARFNFKQTNEDELSVCKGDIIYVTRVEEGGWWEGTLNGRTGWFPSNYVREI-KSSERP 223
Query: 287 LAAERAK 293
L+ + K
Sbjct: 224 LSPKAVK 230
>CE18886_2 [F] KOG2070 Guanine nucleotide exchange factor
Length = 655
Score = 55.5 bits (132), Expect = 2e-07
Identities = 25/54 (46%), Positives = 31/54 (57%)
Query: 228 RAMYDFNSTEQDELSFKKGDLICVVEQVYRDWWRGTLAGSVGIFPLNYVTPVTE 281
RA + F + DELSF K D+I + +Q WW GT G G FP YVT +TE
Sbjct: 21 RAKFQFEGSNNDELSFDKDDIITITQQQEGGWWEGTHEGVTGWFPCAYVTLITE 74
>Hs4507191 [Z] KOG0040 Ca2+-binding actin-bundling protein (spectrin) alpha
chain (EF-Hand protein superfamily)
Length = 2472
Score = 54.7 bits (130), Expect = 3e-07
Identities = 32/126 (25%), Positives = 60/126 (47%), Gaps = 7/126 (5%)
Query: 227 VRAMYDFNSTEQDELSFKKGDLICVVEQVYRDWWRGTLAGSVGIFPLNYV---TPVTEPS 283
V A+YD+ E++ KKGD++ ++ +DWW+ + G P YV P S
Sbjct: 972 VLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPAQSAS 1031
Query: 284 QQELAAERAKDEQVFAQKDNVDRLQNKLREAGNADITQDQEINDLYGSVSPIRPQISKML 343
++ L E+ + +++ +D +EAG+ + Q + +LY S+ + + ML
Sbjct: 1032 RENLLEEQG---SIALRQEQIDNQTRITKEAGSVSLRMKQ-VEELYHSLLELGEKRKGML 1087
Query: 344 GKYAQK 349
K +K
Sbjct: 1088 EKSCKK 1093
>Hs7382493 [C] KOG4773 NADPH oxidase
Length = 348
Score = 54.3 bits (129), Expect = 4e-07
Identities = 21/51 (41%), Positives = 36/51 (70%)
Query: 226 KVRAMYDFNSTEQDELSFKKGDLICVVEQVYRDWWRGTLAGSVGIFPLNYV 276
+ A++DF + EL+FK GD+I ++ ++ +DW GT+ G+ GIFPL++V
Sbjct: 174 RAEALFDFTGNSKLELNFKAGDVIFLLSRINKDWLEGTVRGATGIFPLSFV 224
>Hs4505345 [C] KOG4773 NADPH oxidase
Length = 339
Score = 54.3 bits (129), Expect = 4e-07
Identities = 21/51 (41%), Positives = 36/51 (70%)
Query: 226 KVRAMYDFNSTEQDELSFKKGDLICVVEQVYRDWWRGTLAGSVGIFPLNYV 276
+ A++DF + EL+FK GD+I ++ ++ +DW GT+ G+ GIFPL++V
Sbjct: 174 RAEALFDFTGNSKLELNFKAGDVIFLLSRINKDWLEGTVRGATGIFPLSFV 224
>Hs7661670 [S] KOG1843 Uncharacterized conserved protein
Length = 246
Score = 53.9 bits (128), Expect = 6e-07
Identities = 24/54 (44%), Positives = 33/54 (60%), Gaps = 2/54 (3%)
Query: 226 KVRAMYDFNSTEQDELSFKKGDLICVVEQV--YRDWWRGTLAGSVGIFPLNYVT 277
+V A+Y F + +L+F+ GD I V+ + + DWW G L G GIFP NYVT
Sbjct: 191 EVTALYSFEGQQPGDLNFQAGDRITVISKTDSHFDWWEGKLRGQTGIFPANYVT 244
>Hs4826844 [Z] KOG0162 Myosin class I heavy chain
Length = 1109
Score = 53.9 bits (128), Expect = 6e-07
Identities = 21/56 (37%), Positives = 36/56 (63%)
Query: 224 IRKVRAMYDFNSTEQDELSFKKGDLICVVEQVYRDWWRGTLAGSVGIFPLNYVTPV 279
+ + +A+Y +++ + DELSF D+I ++++ WW G L G G+FP NYVT +
Sbjct: 1054 VPQCKALYAYDAQDTDELSFNANDIIDIIKEDPSGWWTGRLRGKPGLFPNNYVTKI 1109
>7299844 [TZ] KOG2546 Abl interactor ABI-1 contains SH3 domain
Length = 473
Score = 53.9 bits (128), Expect = 6e-07
Identities = 23/55 (41%), Positives = 36/55 (64%)
Query: 224 IRKVRAMYDFNSTEQDELSFKKGDLICVVEQVYRDWWRGTLAGSVGIFPLNYVTP 278
I KV A+YD+ + + DELSF++ ++ V+++ WW G + G G+FP NYV P
Sbjct: 417 IEKVVAIYDYYADKDDELSFQESSVLYVLKKNDDGWWEGVMDGVTGLFPGNYVEP 471
>SPAPJ696.02 [S] KOG1843 Uncharacterized conserved protein
Length = 430
Score = 53.5 bits (127), Expect = 7e-07
Identities = 25/53 (47%), Positives = 34/53 (63%), Gaps = 2/53 (3%)
Query: 226 KVRAMYDFNSTEQDELSFKKGDLICVVEQ--VYRDWWRGTLAGSVGIFPLNYV 276
+ RAMY F + +LSF+KGD+I +VE+ + DWW G + GIFP NYV
Sbjct: 375 QARAMYSFAGEQPGDLSFQKGDIIDIVERSGSHDDWWTGRIGYREGIFPANYV 427
>Hs13994242 [T] KOG4348 Adaptor protein CMS/SETA
Length = 665
Score = 53.5 bits (127), Expect = 7e-07
Identities = 37/133 (27%), Positives = 65/133 (48%), Gaps = 6/133 (4%)
Query: 225 RKVRAMYDFNSTEQDELSFKKGDLICVVEQVYRDWWRGTLAGSVGIFPLNYVTPVTEPSQ 284
R+ + + + DEL K GD+I VV +V WW G L G G+FP N++ ++ S
Sbjct: 101 RRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGES- 159
Query: 285 QELAAERAKDEQVFAQKDNVDRLQNKLREAGNADITQDQEINDLYGSVSPIRPQISKMLG 344
EL ++DEQ+ K ++ + G++ T+ + N + + I+P+ K +G
Sbjct: 160 DELGI--SQDEQL--SKSSLRETTGSESDGGDSSSTKSEGANGTVATAA-IQPKKVKGVG 214
Query: 345 KYAQKKEDLVSLR 357
K+ + LR
Sbjct: 215 FGDIFKDKPIKLR 227
>Hs20555436 [TUZ] KOG2856 Adaptor protein PACSIN
Length = 444
Score = 53.1 bits (126), Expect = 9e-07
Identities = 27/56 (48%), Positives = 39/56 (69%), Gaps = 2/56 (3%)
Query: 226 KVRAMYDFNSTEQDELSFKKGD-LICVVEQVYRDWWRGTL-AGSVGIFPLNYVTPV 279
+VRA+YD++ EQDELSFK GD L + E+ + W RG L +G +G++P NYV +
Sbjct: 389 RVRALYDYDGQEQDELSFKAGDELTKLGEEDEQGWCRGRLDSGQLGLYPANYVEAI 444
>Hs20127477 [TZ] KOG2546 Abl interactor ABI-1 contains SH3 domain
Length = 475
Score = 53.1 bits (126), Expect = 9e-07
Identities = 23/61 (37%), Positives = 39/61 (63%)
Query: 224 IRKVRAMYDFNSTEQDELSFKKGDLICVVEQVYRDWWRGTLAGSVGIFPLNYVTPVTEPS 283
+ KV A+YD+ ++DELSF++G +I V+++ W+ G + G G+FP NYV + S
Sbjct: 415 LEKVVAIYDYTKDKEDELSFQEGAIIYVIKKNDDGWYEGVMNGVTGLFPGNYVESIMHYS 474
Query: 284 Q 284
+
Sbjct: 475 E 475
>CE06781 [TU] KOG1818 Membrane trafficking and cell signaling protein HRS
contains VHS and FYVE domains
Length = 765
Score = 53.1 bits (126), Expect = 9e-07
Identities = 30/134 (22%), Positives = 74/134 (54%), Gaps = 2/134 (1%)
Query: 6 KVKKAIERATDPGLRVDNWGYLIEVCDLVKVDAEDRGQYAMKIIEERLLKQDANMILRTL 65
K ++ +++ATD L NW +I D+++ E + +++ I +R+ ++ +++ TL
Sbjct: 40 KFQRVLDQATDSTLVEPNWEGIILCTDMIR-SGEVPAKPSLQAIRKRMQHENPHVVNHTL 98
Query: 66 SLVVALAENCGSRLQQAISSKHFTGILYKIVDDSQVHVAVKREVLKVVHQLADSFKNDPS 125
++ A +NCG ++ ++++ F +V +++ + VK + L+++ A +F N P
Sbjct: 99 LVLDACVKNCGHKVHAEVATREFMEDFKNLVTENK-YDEVKNKSLEMLQCWATAFANKPE 157
Query: 126 LKYMHDLESKIKIS 139
K + D + +K++
Sbjct: 158 YKMVVDTHNLMKLA 171
>7298672 [F] KOG2070 Guanine nucleotide exchange factor
Length = 687
Score = 53.1 bits (126), Expect = 9e-07
Identities = 27/61 (44%), Positives = 34/61 (55%), Gaps = 6/61 (9%)
Query: 227 VRAMYDFNSTEQDELSFKKGDLICVVEQVYRDWWRGTLAGSVGIFPLNYVT------PVT 280
V+A Y F + DEL F+KGD+I V ++ WW GTL G FP NYV P+T
Sbjct: 7 VQAEYSFMGSNNDELCFQKGDVITVTQREDGGWWEGTLNDKTGWFPSNYVNECKVQLPLT 66
Query: 281 E 281
E
Sbjct: 67 E 67
>CE18195 [IT] KOG1118 Lysophosphatidic acid acyltransferase endophilin/SH3GL
involved in synaptic vesicle formation
Length = 443
Score = 52.8 bits (125), Expect = 1e-06
Identities = 21/49 (42%), Positives = 34/49 (68%)
Query: 228 RAMYDFNSTEQDELSFKKGDLICVVEQVYRDWWRGTLAGSVGIFPLNYV 276
RA++DF++ + EL FK+G LI +V Q+ +W+ G + G G+FP+ YV
Sbjct: 388 RALFDFDAQSEGELDFKEGTLIELVSQIDENWYEGRVNGKTGLFPVTYV 436
>YPR154w [T] KOG3601 Adaptor protein GRB2 contains SH2 and SH3 domains
Length = 215
Score = 52.4 bits (124), Expect = 2e-06
Identities = 21/58 (36%), Positives = 35/58 (60%)
Query: 221 PTVIRKVRAMYDFNSTEQDELSFKKGDLICVVEQVYRDWWRGTLAGSVGIFPLNYVTP 278
P + V A+Y F+ + +L K GD + ++E++ +W++G+ G GIFP NYV P
Sbjct: 53 PASLEYVEALYQFDPQQDGDLGLKPGDKVQLLEKLSPEWYKGSCNGRTGIFPANYVKP 110
>7301982 [T] KOG4348 Adaptor protein CMS/SETA
Length = 352
Score = 52.4 bits (124), Expect = 2e-06
Identities = 38/125 (30%), Positives = 53/125 (42%), Gaps = 8/125 (6%)
Query: 225 RKVRAMYDFNSTEQDELSFKKGDLICVVEQVYRDWWRGTLAGSVGIFPLNYVTPVTEPSQ 284
R+ + +Y + DEL+ GD+I + +V WWRG L VG+FP N+V + EPS
Sbjct: 96 RRCKVIYSYTQVNDDELTLAVGDVIEFLGEVEEGWWRGRLRSKVGVFPSNFVQHI-EPS- 153
Query: 285 QELAAERAKDEQVFAQKDNVDRLQNKLREAGNADITQDQEINDLYGSVSPIRPQISKMLG 344
LA++R L +K N T G+V P IS
Sbjct: 154 PVLASKR---PPTIGATVTTSALTSKAANVANVAATATVPTG---GAVPPASTSISTSTT 207
Query: 345 KYAQK 349
K A K
Sbjct: 208 KQATK 212
>SPAPJ760.02c [Z] KOG3655 Drebrins and related actin binding proteins
Length = 857
Score = 51.6 bits (122), Expect = 3e-06
Identities = 22/55 (40%), Positives = 35/55 (63%)
Query: 225 RKVRAMYDFNSTEQDELSFKKGDLICVVEQVYRDWWRGTLAGSVGIFPLNYVTPV 279
+ V+A+YD+ + E +ELSF + ++I V+ V +WW G G G+FP NYV +
Sbjct: 803 KSVKAIYDYQAQEDNELSFFEDEIIANVDCVDPNWWEGECHGHRGLFPSNYVEEI 857
>Hs5453754 [T] KOG4226 Adaptor protein NCK/Dock contains SH2 and SH3 domains
Length = 377
Score = 51.6 bits (122), Expect = 3e-06
Identities = 25/58 (43%), Positives = 40/58 (68%), Gaps = 3/58 (5%)
Query: 223 VIRKVRAMYDFNSTEQDELSFKKGDLICVVEQVYRD--WWR-GTLAGSVGIFPLNYVT 277
V+ V+A+Y F+S+ +EL+F+KGD++ V+E+ D WW+ + G VG+ P NYVT
Sbjct: 191 VLHVVQALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKINGMVGLVPKNYVT 248
>7303765 [T] KOG4225 Sorbin and SH3 domain-containing protein
Length = 500
Score = 51.6 bits (122), Expect = 3e-06
Identities = 29/100 (29%), Positives = 52/100 (52%), Gaps = 4/100 (4%)
Query: 226 KVRAMYDFNSTEQDELSFKKGDLICVVEQVYRDWWRGTLAGSVGIFPLNYVTPVTEPSQQ 285
+ RA Y+F + ELS KG+L+ + +V +W+ G +A GIFP +YV +T+ +
Sbjct: 316 QARAKYNFQAQSGIELSLNKGELVTLTRRVDGNWFEGKIANRKGIFPCSYVEVLTDIGAE 375
Query: 286 ELAAERA---KDEQVFAQKDNVDRLQNKLREAGNADITQD 322
++AA + + N+D L+ + N +TQ+
Sbjct: 376 DIAARTTTVITSQSTTNLRPNLDVLRTNINNEFNT-LTQN 414
>7294461 [Z] KOG3655 Drebrins and related actin binding proteins
Length = 531
Score = 51.6 bits (122), Expect = 3e-06
Identities = 20/53 (37%), Positives = 36/53 (67%), Gaps = 1/53 (1%)
Query: 225 RKVRAMYDFNSTEQDELSFKKGDLICVVEQVYRDWWRGT-LAGSVGIFPLNYV 276
++ RA+YD+ + ++ E++F GD+I ++Q+ WW+G G+ G+FP NYV
Sbjct: 475 QRARALYDYQAADETEITFDPGDVITHIDQIDEGWWQGLGPDGTYGLFPANYV 527
>Hs7108367 [T] KOG2996 Rho guanine nucleotide exchange factor VAV3
Length = 845
Score = 51.2 bits (121), Expect = 4e-06
Identities = 23/50 (46%), Positives = 34/50 (68%), Gaps = 1/50 (2%)
Query: 228 RAMYDFNSTEQDELSFKKGDLICVVEQV-YRDWWRGTLAGSVGIFPLNYV 276
+A YDF + ++ ELS K+GD+I ++ + + WWRG + G VG FP NYV
Sbjct: 788 KARYDFCARDRSELSLKEGDIIKILNKKGQQGWWRGEIYGRVGWFPANYV 837
>Hs4506929 [IT] KOG1118 Lysophosphatidic acid acyltransferase endophilin/SH3GL
involved in synaptic vesicle formation
Length = 368
Score = 51.2 bits (121), Expect = 4e-06
Identities = 21/49 (42%), Positives = 30/49 (60%)
Query: 228 RAMYDFNSTEQDELSFKKGDLICVVEQVYRDWWRGTLAGSVGIFPLNYV 276
+A+YDF EL F +GD+I + Q+ +W+ G L G G FPL+YV
Sbjct: 312 KALYDFEPENDGELGFHEGDVITLTNQIDENWYEGMLDGQSGFFPLSYV 360
>Hs5453710 [Z] KOG1702 Nebulin repeat protein
Length = 261
Score = 50.8 bits (120), Expect = 5e-06
Identities = 22/57 (38%), Positives = 37/57 (64%), Gaps = 2/57 (3%)
Query: 225 RKVRAMYDFNSTEQDELSFKKGDLICVVEQVYRDWWRGTL--AGSVGIFPLNYVTPV 279
++ RA+YD+++ ++DE+SF+ GD I V+Q+ W GT+ G G+ P NYV +
Sbjct: 205 KRYRAVYDYSAADEDEVSFQDGDTIVNVQQIDDGWMYGTVERTGDTGMLPANYVEAI 261
>Hs16418431 [R] KOG4429 Uncharacterized conserved protein contains SH3 and FCH
domains
Length = 428
Score = 50.8 bits (120), Expect = 5e-06
Identities = 21/52 (40%), Positives = 32/52 (61%)
Query: 225 RKVRAMYDFNSTEQDELSFKKGDLICVVEQVYRDWWRGTLAGSVGIFPLNYV 276
R +A+Y F + + DEL+ +KGD++ + E+ WW G+L G G FP YV
Sbjct: 363 RLCKALYSFQARQDDELNLEKGDIVIIHEKKEEGWWFGSLNGKKGHFPAAYV 414
>7302755_2 [S] KOG2995 FOG: SH3 domain
Length = 701
Score = 50.8 bits (120), Expect = 5e-06
Identities = 22/48 (45%), Positives = 31/48 (63%)
Query: 229 AMYDFNSTEQDELSFKKGDLICVVEQVYRDWWRGTLAGSVGIFPLNYV 276
A++DF S E +L FKKGDLI + ++ +W+ G G G FP+NYV
Sbjct: 5 ALFDFASGEATDLKFKKGDLILIKHRIDNNWFVGQANGQEGTFPINYV 52
>YFR024c-a [S] KOG1843 Uncharacterized conserved protein
Length = 451
Score = 50.4 bits (119), Expect = 6e-06
Identities = 23/53 (43%), Positives = 32/53 (59%), Gaps = 2/53 (3%)
Query: 226 KVRAMYDFNSTEQDELSFKKGDLICVVEQV--YRDWWRGTLAGSVGIFPLNYV 276
K A+Y F E +L F+KGD+I ++++ DWW G + G GIFP NYV
Sbjct: 396 KAVALYSFAGEESGDLPFRKGDVITILKKSDSQNDWWTGRVNGREGIFPANYV 448
>YFR024c [S] KOG1843 Uncharacterized conserved protein
Length = 373
Score = 50.4 bits (119), Expect = 6e-06
Identities = 23/53 (43%), Positives = 32/53 (59%), Gaps = 2/53 (3%)
Query: 226 KVRAMYDFNSTEQDELSFKKGDLICVVEQV--YRDWWRGTLAGSVGIFPLNYV 276
K A+Y F E +L F+KGD+I ++++ DWW G + G GIFP NYV
Sbjct: 318 KAVALYSFAGEESGDLPFRKGDVITILKKSDSQNDWWTGRVNGREGIFPANYV 370
>Hs4885639 [U] KOG1087 Cytosolic sorting protein GGA2/TOM1
Length = 476
Score = 50.4 bits (119), Expect = 6e-06
Identities = 26/79 (32%), Positives = 45/79 (56%), Gaps = 2/79 (2%)
Query: 11 IERATDPGLRVDNWGYLIEVCDLVKVDAEDRGQYAMKIIEERLLKQ-DANMILRTLSLVV 69
IE+AT G++ ++WG + +CD++ +D + A+K +++R+ K + I TLSL+
Sbjct: 19 IEKATFAGVQTEDWGQFMHICDIINT-TQDAPKDAVKALKKRISKNYNHKEIQLTLSLID 77
Query: 70 ALAENCGSRLQQAISSKHF 88
+NCG Q I K F
Sbjct: 78 MCVQNCGPSFQSLIVKKEF 96
>Hs22060285 [T] KOG4348 Adaptor protein CMS/SETA
Length = 150
Score = 50.4 bits (119), Expect = 6e-06
Identities = 34/111 (30%), Positives = 54/111 (48%), Gaps = 5/111 (4%)
Query: 225 RKVRAMYDFNSTEQDELSFKKGDLICVVEQVYRDWWRGTLAGSVGIFPLNYVTPVTEPSQ 284
R+ + + + DEL K GD+I VV +V WW G L G G+FP N++ ++ S
Sbjct: 42 RRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGES- 100
Query: 285 QELAAERAKDEQVFAQK--DNVDRLQNKLREAGNADITQDQEINDLYGSVS 333
EL ++DEQ+ + V + R N + QD+E L ++S
Sbjct: 101 DELGI--SQDEQLSKSNYWEEVTCNYSNSRLIKNRNGQQDKEQGLLQSNIS 149
>YHR016c [S] KOG1843 Uncharacterized conserved protein
Length = 468
Score = 50.1 bits (118), Expect = 8e-06
Identities = 22/50 (44%), Positives = 32/50 (64%), Gaps = 2/50 (4%)
Query: 229 AMYDFNSTEQDELSFKKGDLICVVEQV--YRDWWRGTLAGSVGIFPLNYV 276
A+Y+F + +L+FKKGD+I ++++ DWW G G GIFP NYV
Sbjct: 416 ALYNFAGEQPGDLAFKKGDVITILKKSDSQNDWWTGRTNGKEGIFPANYV 465
>Hs4507189 [Z] KOG0040 Ca2+-binding actin-bundling protein (spectrin) alpha
chain (EF-Hand protein superfamily)
Length = 2429
Score = 50.1 bits (118), Expect = 8e-06
Identities = 24/88 (27%), Positives = 46/88 (52%), Gaps = 2/88 (2%)
Query: 225 RKVRAMYDFNSTEQDELSFKKGDLICVVEQVYRDWWRGTLAGSVGIFPLNYVTPVTEPSQ 284
++V A+YDF + E++ KKGD++ ++ + +DWW+ A GI P YV +
Sbjct: 980 QRVMALYDFQARSPREVTMKKGDVLTLLSSINKDWWKVEAADHQGIVPAVYVRRLAHDEF 1039
Query: 285 QELAAERAKDEQVFAQKDNVDRLQNKLR 312
L R ++ Q+ ++++N+ R
Sbjct: 1040 PMLPQRRREEPGNITQRQ--EQIENQYR 1065
>Hs4505195 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 847
Score = 50.1 bits (118), Expect = 8e-06
Identities = 28/69 (40%), Positives = 39/69 (55%), Gaps = 11/69 (15%)
Query: 229 AMYDFNSTEQDELSFKKGDLICVVEQVYRD--------WWRGTLAGSVGIFPLNYVTPVT 280
A++D+ + QDEL+ +KGD VE + RD WW G + G VGIFP NYV+
Sbjct: 48 ALFDYEPSGQDELALRKGDR---VEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGG 104
Query: 281 EPSQQELAA 289
P E+A+
Sbjct: 105 GPPPCEVAS 113
>Hs21361641 [R] KOG0266 WD40 repeat-containing protein
Length = 1196
Score = 50.1 bits (118), Expect = 8e-06
Identities = 32/105 (30%), Positives = 55/105 (51%), Gaps = 9/105 (8%)
Query: 221 PTVIRKVRAMYDFNSTEQDELSFKKGDLICVVEQVYRDWWRGTLA-GSVGIFPLNYVTPV 279
PTV+ A+YD+ + DEL+ +GD+I V + DWW G++ G G FP N+V
Sbjct: 1054 PTVV----ALYDYTANRSDELTIHRGDIIRVFFKDNEDWWYGSIGKGQEGYFPANHV--A 1107
Query: 280 TEPSQQELAAERAKDEQVFA--QKDNVDRLQNKLREAGNADITQD 322
+E QEL E + + +K +++ +++ N + +QD
Sbjct: 1108 SETLYQELPPEIKERSPPLSPEEKTKIEKSPAPQKQSINKNKSQD 1152
>Hs20336267 [U] KOG1087 Cytosolic sorting protein GGA2/TOM1
Length = 723
Score = 50.1 bits (118), Expect = 8e-06
Identities = 32/144 (22%), Positives = 69/144 (47%), Gaps = 9/144 (6%)
Query: 11 IERATDPGLRVDNWGYLIEVCDLVKVDAEDRGQYAMKIIEERLLKQDANMILRTLSLVVA 70
+ +AT+P R ++W Y+I CD + + E Q A++++ ++ L+ L+++ A
Sbjct: 13 LNKATNPSNRQEDWEYIIGFCDQINKELEGP-QIAVRLLAHKIQSPQEWEALQALTVLEA 71
Query: 71 LAENCGSRLQQAISSKHFTGILYKIVD----DSQVHVAVKREVLKVVHQLADSFKNDPSL 126
+NCG R + F L K+V +V VK +V+++++ + + +
Sbjct: 72 CMKNCGRRFHNEVGKFRFLNELIKVVSPKYLGDRVSEKVKTKVIELLYSWTMALPEEAKI 131
Query: 127 KYMHDLESKIKISHPELISEPRVP 150
K + + + I + S+P +P
Sbjct: 132 KDAYHMLKRQGI----VQSDPPIP 151
>Hs17474837_1 [Z] KOG1654 Microtubule-associated anchor protein involved in
autophagy and membrane trafficking
Length = 171
Score = 50.1 bits (118), Expect = 8e-06
Identities = 24/56 (42%), Positives = 33/56 (58%), Gaps = 3/56 (5%)
Query: 221 PTVIRKVRAMYDFNSTEQDELSFKKGDLICVVEQVYRDWWRGTLAGSVGIFPLNYV 276
P+V+RK F+ DEL F+KGD+I V + +WW+GT G G+ P NYV
Sbjct: 116 PSVVRKTD---HFSPRTPDELCFEKGDIIYVTDMNDANWWKGTSKGRTGLTPSNYV 168
>7300664_2 [TUZ] KOG2856 Adaptor protein PACSIN
Length = 481
Score = 50.1 bits (118), Expect = 8e-06
Identities = 22/51 (43%), Positives = 35/51 (68%), Gaps = 1/51 (1%)
Query: 227 VRAMYDFNSTEQDELSFKKGDLICVVE-QVYRDWWRGTLAGSVGIFPLNYV 276
V+A+YD+ E DEL+FK+GD+ +E + + W +G + G VG++P NYV
Sbjct: 428 VKALYDYEGAESDELTFKQGDVFEKLEDEDEQGWCKGRMNGRVGLYPANYV 478
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.313 0.131 0.371
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,944,377
Number of Sequences: 60738
Number of extensions: 816325
Number of successful extensions: 2605
Number of sequences better than 1.0e-05: 69
Number of HSP's better than 0.0 without gapping: 43
Number of HSP's successfully gapped in prelim test: 26
Number of HSP's that attempted gapping in prelim test: 2467
Number of HSP's gapped (non-prelim): 124
length of query: 508
length of database: 30,389,216
effective HSP length: 111
effective length of query: 397
effective length of database: 23,647,298
effective search space: 9387977306
effective search space used: 9387977306
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)