ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactII3669 good I KOG1889 Lipid transport and metabolism Putative phosphoinositide phosphatase
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactII3669 1264300 1262426 -625
(625 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YKL212w [I] KOG1889 Putative phosphoinositide phosphatase 788 0.0
SPBC19F5.03 [I] KOG1889 Putative phosphoinositide phosphatase 394 e-109
Hs7662338 [I] KOG1889 Putative phosphoinositide phosphatase 306 8e-83
7292047 [I] KOG1889 Putative phosphoinositide phosphatase 299 1e-80
CE09807 [I] KOG1889 Putative phosphoinositide phosphatase 269 1e-71
Hs7662414 [I] KOG1890 Phosphoinositide phosphatase SAC1 250 4e-66
7300754 [I] KOG1890 Phosphoinositide phosphatase SAC1 231 2e-60
At5g66020 [I] KOG1889 Putative phosphoinositide phosphatase 229 7e-60
At3g51830 [I] KOG1889 Putative phosphoinositide phosphatase 210 6e-54
At3g51460 [I] KOG1889 Putative phosphoinositide phosphatase 199 1e-50
CE20170 [I] KOG1890 Phosphoinositide phosphatase SAC1 194 3e-49
YNL106c [U] KOG0566 Inositol-145-triphosphate 5-phosphatase (syn... 174 4e-43
YOR109w [U] KOG0566 Inositol-145-triphosphate 5-phosphatase (syn... 169 9e-42
SPBC2G2.02 [U] KOG0566 Inositol-145-triphosphate 5-phosphatase (... 166 1e-40
YNL325c [I] KOG1888 Putative phosphoinositide phosphatase 164 4e-40
CE08566 [I] KOG1888 Putative phosphoinositide phosphatase 158 3e-38
Hs7662034 [I] KOG1888 Putative phosphoinositide phosphatase 157 5e-38
CE29050 [U] KOG0566 Inositol-145-triphosphate 5-phosphatase (syn... 150 4e-36
CE28239 [U] KOG0566 Inositol-145-triphosphate 5-phosphatase (syn... 150 4e-36
SPAC3C7.01c [I] KOG1889 Putative phosphoinositide phosphatase 149 1e-35
7291368 [U] KOG0566 Inositol-145-triphosphate 5-phosphatase (syn... 146 8e-35
Hs4507335 [U] KOG0566 Inositol-145-triphosphate 5-phosphatase (s... 144 3e-34
7295697 [I] KOG1888 Putative phosphoinositide phosphatase 141 3e-33
At3g43220 [I] KOG1888 Putative phosphoinositide phosphatase 139 1e-32
Hs14747866 [U] KOG0566 Inositol-145-triphosphate 5-phosphatase (... 135 2e-31
At1g17340 [I] KOG1888 Putative phosphoinositide phosphatase 135 2e-31
ECU03g1160 [I] KOG1889 Putative phosphoinositide phosphatase 126 9e-29
ECU08g1420 [U] KOG0566 Inositol-145-triphosphate 5-phosphatase (... 112 2e-24
At1g22620 [I] KOG1888 Putative phosphoinositide phosphatase 106 1e-22
At5g20840 [I] KOG1888 Putative phosphoinositide phosphatase 103 6e-22
SPBC577.13 [U] KOG0566 Inositol-145-triphosphate 5-phosphatase (... 98 3e-20
YIL002c [U] KOG0566 Inositol-145-triphosphate 5-phosphatase (syn... 74 9e-13
At3g59770 [I] KOG1888 Putative phosphoinositide phosphatase 64 9e-10
>YKL212w [I] KOG1889 Putative phosphoinositide phosphatase
Length = 623
Score = 788 bits (2034), Expect = 0.0
Identities = 374/625 (59%), Positives = 468/625 (74%), Gaps = 2/625 (0%)
Query: 1 MRGPLLVCQEKDRVLLKVASSSSKNDAVLNVSTHENEVNVLGSTEFPVRGNIMKVAALIG 60
M GP++ Q D + K+A NDAV++++ + V VLG+ EFPV+G ++K+A+L+G
Sbjct: 1 MTGPIVYVQNADGIFFKLAEGKGTNDAVIHLANQDQGVRVLGAEEFPVQGEVVKIASLMG 60
Query: 61 IIKLKFGKYVIIANRVEEAGCLNGHNVYKVAEHTIISVDKKQRPDSDESQYLQLLEQHLA 120
IKLK +Y IIAN VEE G NGH Y+V +H+I+S R DS+E++Y++LLE HL
Sbjct: 61 FIKLKLNRYAIIANTVEETGRFNGHVFYRVLQHSIVSTKFNSRIDSEEAEYIKLLELHLK 120
Query: 121 GATLFYSYGYDLTNSAQRNEELESSAVSWEQADRRFFWNYYVTESLQKLAKVDDRVSDFI 180
+T ++SY YDLTNS QRNE++ A SW+ AD RFFWN+Y+TE L+ A D R+ FI
Sbjct: 121 NSTFYFSYTYDLTNSLQRNEKV-GPAASWKTADERFFWNHYLTEDLRNFAHQDPRIDSFI 179
Query: 181 IPMIYGYAKVVDTVFHATPISIGLITRRSIFRAGTRYFRRGIDEHGNVGNFNETEQVLCV 240
P+IYGYAK VD V +ATPI +GLITRRSIFRAGTRYFRRG+D+ GNVGNFNETEQ+L
Sbjct: 180 QPVIYGYAKTVDAVLNATPIVLGLITRRSIFRAGTRYFRRGVDKDGNVGNFNETEQILLA 239
Query: 241 QKPMKDGYHFFSFLQTRGSVPVYWAEXXXXXXXXXXXXAENSSLDATKKHFDEQTRXXXX 300
+ P + H FSFLQTRGSVP+YWAE ENS LDATKKHFD+Q
Sbjct: 240 ENPESEKIHVFSFLQTRGSVPIYWAEINNLKYKPNLVLGENS-LDATKKHFDQQKELYGD 298
Query: 301 XXXXXXXXQKGHELPVKEAYEQVVTALNDPKLHYIYFDFHHECRNMQWHKVKLLLDHLQS 360
QKGHELPVKE YE VV ALNDPK+HY+YFDFHHECR MQWH+VKLL+DHL+
Sbjct: 299 NYLVNLVNQKGHELPVKEGYESVVHALNDPKIHYVYFDFHHECRKMQWHRVKLLIDHLEK 358
Query: 361 MGLSNKDFFHKTLDANGVTLQVFSKQQSVVRTNCMDCLDRTNVVQSVLAHWVLQEEFKTV 420
+GLSN+DFFHK +D+NG T+++ ++Q SVVRTNCMDCLDRTNVVQSVLA WVLQ+EF++
Sbjct: 359 LGLSNEDFFHKVIDSNGNTVEIVNEQHSVVRTNCMDCLDRTNVVQSVLAQWVLQKEFESA 418
Query: 421 GLTDDTGLWELDKNLLFEFQSFWADNADAVSVAYSGTGALKTDFTRTGKRTYLGAIKDGI 480
+ WE + LL +Q+ WADNADAVSVAYSGTGALKTDFTRTGKRT LGA D +
Sbjct: 419 DVVATGSTWEDNAPLLTSYQNLWADNADAVSVAYSGTGALKTDFTRTGKRTRLGAFNDFL 478
Query: 481 NSISRYYQNNLTDGPREDAFDLFLGNFRPYASVVHSPFPDRRPMLIQAVPTMIYAALTVM 540
NS SRYYQNN TDGPR+D++DLFLG FRP+ + + SPFPDRRP+ IQ +P +I AALTV+
Sbjct: 479 NSASRYYQNNWTDGPRQDSYDLFLGGFRPHTASIKSPFPDRRPVYIQLIPMIICAALTVL 538
Query: 541 MATILFPKNHFTSAKNLSFFFGSFSIVVLCTHFVFKRGIQYVNWPKLVDLGYLIAEHTHN 600
ATI FPK+ FTS+KNL +F G+ ++ L T F+FK GIQ+VNWPKLVD+G+L+ TH+
Sbjct: 539 GATIFFPKDRFTSSKNLLYFAGASIVLALSTKFMFKNGIQFVNWPKLVDVGFLVVHQTHD 598
Query: 601 KEKQFKGVRYVPDPKFVKPNSFKRD 625
KE+QFKG++Y PKF KP+ KRD
Sbjct: 599 KEQQFKGLKYAQSPKFSKPDPLKRD 623
>SPBC19F5.03 [I] KOG1889 Putative phosphoinositide phosphatase
Length = 598
Score = 394 bits (1011), Expect = e-109
Identities = 227/576 (39%), Positives = 314/576 (54%), Gaps = 11/576 (1%)
Query: 24 KNDAVLNVSTHENEVNVLGSTEFPVRGNIMKVAALIGIIKLKFGKYVIIANRVEEAGCLN 83
+ D L + V+ PV + L G IKLK KY+I+A A +
Sbjct: 15 REDCCLTIDRESGAVSFEPDELKPVARSKENSVTLFGSIKLKKDKYLILATEKSSAAQIL 74
Query: 84 GHNVYKVAEHTIISVDKKQRPDSDESQYLQLLEQHLAGATLFYSYGYDLTNSAQRNEELE 143
GH +Y+V + +I D DE LL+ HL ++SY +DLTNS QR+ E
Sbjct: 75 GHKIYRVHKFEVIPYRNLLADDQDELDLYNLLQNHLKTGPFYFSYTWDLTNSLQRSCTDE 134
Query: 144 SSAVSWEQADRRFFWNYYVTESLQKLAKVDDRVSDFIIPMIYGYAKVVDTVFHATPISIG 203
A ++D+RFFWN + ++ L VS FI PMIYG+ T+ I++
Sbjct: 135 GKASPILRSDKRFFWNEFASKDFIDLIGAHSEVSLFITPMIYGFITSASTIVKGRTITLA 194
Query: 204 LITRRSIFRAGTRYFRRGIDEHGNVGNFNETEQVLCVQKPMKDGYHFFSFLQTRGSVPVY 263
LI+RRS RAGTRYF RG+DE+GN NFNETEQ+ V + +S +QTRGSVP +
Sbjct: 195 LISRRSKQRAGTRYFTRGLDENGNPANFNETEQITIVSDEKSE--VTYSHVQTRGSVPAF 252
Query: 264 WAEXXXXXXX-XXXXXAENSSLDATKKHFDEQTRXXXXXXXXXXXXQKGHELPVKEAYEQ 322
WAE + + + A KKHFDEQ KGHELP+K+ YE
Sbjct: 253 WAEVNNLRYKPLMVANSASMAAAAAKKHFDEQISIYGDQVVVNLVNCKGHELPIKQLYEN 312
Query: 323 VVTALNDPKLHYIYFDFHHECRNMQWHKVKLLLDHLQSMGLSNKDFFHKTLDANGVTLQV 382
V+ L++P +HY YFDFH EC +M+W +V LLL+ +Q ++ + TLD +V
Sbjct: 313 VIRRLDNPHIHYHYFDFHKECSHMRWDRVSLLLNEIQP---ELEEQGYTTLDTQ--KYRV 367
Query: 383 FSKQQSVVRTNCMDCLDRTNVVQSVLAHWVLQEEFKTVGLTDDTGLWELDKNLLFEFQSF 442
S+Q VVR+NCMDCLDRTNVVQS + WVL + + G+ T L F +
Sbjct: 368 LSRQNGVVRSNCMDCLDRTNVVQSCIGRWVLTNQLRKCGIIGATHPLRSVIPLDNIFCNI 427
Query: 443 WADNADAVSVAYSGTGALKTDFTRTGKRTYLGAIKDGINSISRYYQNNLTDGPREDAFDL 502
W+DNAD +S++YSGTGALKTDFTRTG RT GA D +NS RY NN DG R+DA+DL
Sbjct: 428 WSDNADYISLSYSGTGALKTDFTRTGIRTRKGAFNDFVNSAKRYILNNFYDGARQDAYDL 487
Query: 503 FLGNFRPYASVVHSPFPDRRPMLIQAVPTMIYAALTVMMATILFPKNHFTSAKNLSFFFG 562
LG FRP + + D RP+ I+ VP ++ A L + T LF ++ T
Sbjct: 488 VLGQFRPDVNFRYR--LDLRPLTIRCVPYILLACLILFFMT-LFSRSSSTILPPSILLIL 544
Query: 563 SFSIVVLCTHFVFKRGIQYVNWPKLVDLGYLIAEHT 598
+F +V ++ F G+Q++NWP+L+ +L ++ T
Sbjct: 545 TFLGIVASLYYCFAHGLQFINWPRLLLPSFLRSDMT 580
>Hs7662338 [I] KOG1889 Putative phosphoinositide phosphatase
Length = 587
Score = 306 bits (783), Expect = 8e-83
Identities = 192/572 (33%), Positives = 296/572 (51%), Gaps = 27/572 (4%)
Query: 26 DAVLNVSTHENEVNVLGSTEFPVRGNIMKVAALIGIIKLKFGKYVIIANRVEEAGCLNGH 85
D VL + EV + + P + ++G I L G Y+I+ + + G H
Sbjct: 28 DDVLTIDRVSTEVTLAVKKDVPPSAVTRPIFGILGTIHLVAGNYLIVITKKIKVGEFFSH 87
Query: 86 NVYKVAEHTIISVDKKQRPDSD-----ESQYLQLLEQHLAGATLFYSYGYDLTNSAQR-- 138
V+K + ++S K +D +L +L L ++S YDLT++ QR
Sbjct: 88 VVWKATDFDVLSYKKTMLHLTDIQLQDNKTFLAMLNHVLNVDGFYFSTTYDLTHTLQRLS 147
Query: 139 NEELESSAVSW-EQADRRFFWNYYVTESLQKLAKVDDRVSDFIIPMIYGYAKVVDTVFHA 197
N E +S E+AD+RF WN ++ L V F +P+++G+ + +
Sbjct: 148 NTSPEFQEMSLLERADQRFVWNGHLLRELS----AQPEVHRFALPVLHGFITMHSCSING 203
Query: 198 TPISIGLITRRSIFRAGTRYFRRGIDEHGNVGNFNETEQVLCVQKPMKDGYHFFSFLQTR 257
LI+RRS FRAG RY+ RGID G+ NF ETEQ++ SF+QTR
Sbjct: 204 KYFDWILISRRSCFRAGVRYYVRGIDSEGHAANFVETEQIVHYNGSKA------SFVQTR 257
Query: 258 GSVPVYWAEXXXXXXXXXXXXAENSS-LDATKKHFDEQTRXXXXXXXXXXXXQKGHELPV 316
GS+PV+W++ ++ ++ +D ++HFD Q QKG E P+
Sbjct: 258 GSIPVFWSQRPNLKYKPLPQISKVANHMDGFQRHFDSQVIIYGKQVIINLINQKGSEKPL 317
Query: 317 KEAYEQVVTALNDPKLHYIYFDFHHECRNMQWHKVKLLLDHLQSMGLSNKDFFHKTLDAN 376
++ + +V++L + YI FDFH EC+NM+W ++ +LLD + M + + +D+
Sbjct: 318 EQTFATMVSSLGSGMMRYIAFDFHKECKNMRWDRLSILLDQVAEM---QDELSYFLVDSA 374
Query: 377 GVTLQVFSKQQSVVRTNCMDCLDRTNVVQSVLAHWVLQEEFKTVGLTDDTGLWELDKNLL 436
G QV + Q+ V R+NCMDCLDRTNV+QS+LA LQ + + +G+ E
Sbjct: 375 G---QVVANQEGVFRSNCMDCLDRTNVIQSLLARRSLQAQLQRLGVLHVGQKLEEQDEFE 431
Query: 437 FEFQSFWADNADAVSVAYSGTGALKTDFTRTGKRTYLGAIKDGINSISRYYQNNLTDGPR 496
+++ WADNA+A + Y+GTGALKTDFTRTGKRT+LG I DG NS+ RYY+NN +DG R
Sbjct: 432 KIYKNAWADNANACAKQYAGTGALKTDFTRTGKRTHLGLIMDGWNSMIRYYKNNFSDGFR 491
Query: 497 EDAFDLFLGNFRPYASVVHSPFPDRRPMLIQAVPTMIYAALTVMMATILFPKNHFTSAKN 556
+D+ DLFLGN+ HSP R A+P ++ A ++ + +L + +T
Sbjct: 492 QDSIDLFLGNYSVDELESHSPLSVPRDWKFLALPIIMVVAFSMCIICLLMAGDTWTETLA 551
Query: 557 LSFFFGSFSIVVLCTHFVFKRGIQYVNWPKLV 588
F+G SI + G +V+ P+LV
Sbjct: 552 YVLFWGVASIGTF--FIILYNGKDFVDAPRLV 581
>7292047 [I] KOG1889 Putative phosphoinositide phosphatase
Length = 592
Score = 299 bits (765), Expect = 1e-80
Identities = 189/544 (34%), Positives = 277/544 (50%), Gaps = 30/544 (5%)
Query: 54 KVAALIGIIKLKFGKYVIIANRVEEAGCLNGHNVYKVAEHTIISVDKKQRPDSDESQYLQ 113
++ ++G I L Y+++A G LNG V+++A + II + YL+
Sbjct: 60 RICGVLGTIHLLSCDYLLVATHRLFVGVLNGAVVWRLAGYDIIPYIPNSFQRKENENYLR 119
Query: 114 LLEQHLAGATLFYSYGYDLTNSAQRNEELESSAVS----WEQADRRFFWNYYVTESLQKL 169
LL Q L ++SY YDLTNS QR E+ S ++A++RF WN YV
Sbjct: 120 LLRQTLDTKFFYFSYRYDLTNSLQRQREVAQSRPEVSGLLQRAEQRFVWNGYVLRQFNC- 178
Query: 170 AKVDDRVSDFIIPMIYGYAKVVDTVFHATPISIGLITRRSIFRAGTRYFRRGIDEHGNVG 229
D++ F +P++ G+ + + +ITRRS+ RAGTR F RG DE G+V
Sbjct: 179 ----DKMEKFQLPLVLGFVSINQVQINGQTFFWSIITRRSVQRAGTRLFCRGSDEQGHVA 234
Query: 230 NFNETEQVLCVQKPMKDGYHFFSFLQTRGSVPVYWAEXXXXXXXXXXXXAENSS-LDATK 288
NF ETEQ++ + F+QTRGS+P +W + L A
Sbjct: 235 NFVETEQIVEFNGQLT------GFVQTRGSMPFHWHQLPNLRYKPRPVLVPGKDHLAACG 288
Query: 289 KHFDEQTRXXXXXXXXXXXXQKGHELPVKEAYEQVVTALNDPKLHYIYFDFHHECRNMQW 348
HF EQ R KG E ++ Y ++V + +P++ Y FDFH ECR M+W
Sbjct: 289 LHFKEQIRLYGNNVAVNLVDHKGAEGELEATYARLVREMGNPQVRYESFDFHSECRKMRW 348
Query: 349 HKVKLLLDHLQSMGLSNKDFFHKTLDANGVTLQVFSKQQSVVRTNCMDCLDRTNVVQSVL 408
++ +L+D L + +H D ++ S Q V RTNC+DCLDRTNVVQS+L
Sbjct: 349 DRLNILIDRL-AHEQDQFGVYHVFDDG-----KLVSTQTGVFRTNCIDCLDRTNVVQSML 402
Query: 409 AHWVLQEEFKTVGLTDDTGLWELDKNLLFE--FQSFWADNADAVSVAYSGTGALKTDFTR 466
A L + +G+ G + +FE F+ WADNAD VS+ YSGT ALKTDFTR
Sbjct: 403 ARRSLTAVLQKLGVLH-VGQKVEHASDIFESIFKGVWADNADLVSLQYSGTCALKTDFTR 461
Query: 467 TGKRTYLGAIKDGINSISRYYQNNLTDGPREDAFDLFLGNF---RPYASVVHSPFPDRRP 523
TGKRT GA++DG NS+ RYY NN DG R+D+ DLFLG + V SP +
Sbjct: 462 TGKRTKSGAMQDGKNSLMRYYLNNFADGQRQDSIDLFLGKYLVNDNEGGAVPSPLESKHG 521
Query: 524 MLIQAVPTMIYAALTVMMATILFPKNHFTSAKNLSFFFGSFSIVVLCTHFVFKRGIQYVN 583
P+++ A+ + M T+ +P T +NL F +++ + + G+++V
Sbjct: 522 WRFFTFPSVLLVAVAMFMITMTYPAEFNT--ENLLFMLFWGAMIAVSATGILHYGVEFVQ 579
Query: 584 WPKL 587
WP+L
Sbjct: 580 WPRL 583
>CE09807 [I] KOG1889 Putative phosphoinositide phosphatase
Length = 591
Score = 269 bits (687), Expect = 1e-71
Identities = 190/583 (32%), Positives = 288/583 (48%), Gaps = 51/583 (8%)
Query: 29 LNVSTHENEVNVLGSTE--FPVRGNIMK-VAALIGIIKLKFGKYVIIANRVEEAGCLNGH 85
L + H N + ++ S + P+ +K + ++G IKL G +I+ + G +N H
Sbjct: 33 LEIDRHTNVMKIIDSRKQRVPIADTDIKFIYGILGTIKLVSGYALIVITKASLIGQVNNH 92
Query: 86 NVYKVAEHTIISVDKKQRPDSDESQ------YLQLLEQHLAGATLFYSYGYDLTNSAQRN 139
N++ + + II KK E Q + +L L+ +YS D++ + Q
Sbjct: 93 NIWTIQDAEIIPY-KKTTLHLTEKQIRYNRLFTDMLTHVLSIGGFYYSTTLDISRTFQWL 151
Query: 140 EE----LESSAVSWEQADRRFFWNYYVTESLQKLAKVDDRVSDFIIPMIYGYAKVVDTVF 195
+E L + ++A RF WN ++ ++++ + + +P+I+G+
Sbjct: 152 QENAVPLFKTRSMLDRASERFIWNGHLLSQIRQVPGAER----YTLPVIHGFIGQNRVNV 207
Query: 196 HATPISIGLITRRSIFRAGTRYFRRGIDEHGNVGNFNETEQVLCVQKPMKDGYHFFSFLQ 255
+ I + +I+RRSI+RAG R+++RG+D G+ NF ETEQ++ P K H SF+Q
Sbjct: 208 NGKEIKLTIISRRSIYRAGVRFYKRGVDVDGHAANFVETEQIVEYTNPDK---HLTSFVQ 264
Query: 256 TRGSVPVYWAEXX--------XXXXXXXXXXAENSSLDATKKHFDEQTRXXXXXXXXXXX 307
RGS+P+ W + A N + K+H+ +
Sbjct: 265 LRGSIPLLWTQKPNLRWQPMPTLKPTDDQLAAFNRAFSWHKQHYGGK------HVIVNLV 318
Query: 308 XQKGHELPVKEAYEQVVTALNDPKLHYIYFDFHHECRNMQWHKVKLLLDHLQSMGLSNKD 367
QKG E V E++ N + Y FDFH EC +MQWH++ LL + L S +S+
Sbjct: 319 NQKGREKKVGGELERISRQANIEFVRYHQFDFHKECHSMQWHRIDLLREQL-SQEISSFG 377
Query: 368 FFHKTLDANGVTLQVFSKQQSVVRTNCMDCLDRTNVVQSVLAHWVLQEEFKTVGLTDDTG 427
+F+ L N + F Q+ RTNCMDCLDRTNVVQS+LA L E+ + +G+
Sbjct: 378 YFY--LSPNSMETSRF--QRGFFRTNCMDCLDRTNVVQSMLARESLTEQLRMLGILYSEQ 433
Query: 428 LWELDKNLLFEFQSFWADNADAVSVAYSGTGALKTDFTRTGKRTYLGAIKDGINSISRYY 487
+ L F+ WADN D S Y+GTGALK DFTR G+RTY+GA+KDG+N++SRY
Sbjct: 434 KVQDIPLLEDAFKQMWADNGDECSRQYAGTGALKADFTRHGRRTYVGAMKDGVNAVSRYV 493
Query: 488 QNNLTDGPREDAFDLFLGNFRPYASVVHSPFPDRRPMLIQAVP---TMIYAALTVMMATI 544
+NN DG R+D+ DLFLGNF V S P I + + AAL M TI
Sbjct: 494 RNNFGDGYRQDSIDLFLGNF----LVDSSDLPVSLESSILSTDQNGLALIAALFAMSMTI 549
Query: 545 LFPKNHFTSAKNLSFFFGSFSIVVLCTHFVFKRGIQYVNWPKL 587
L A N + I +C F+F G ++VN PKL
Sbjct: 550 LC----LLVADNFTATIFWMVIFFVCMMFIFLNGEEFVNAPKL 588
>Hs7662414 [I] KOG1890 Phosphoinositide phosphatase SAC1
Length = 1132
Score = 250 bits (639), Expect = 4e-66
Identities = 157/440 (35%), Positives = 228/440 (51%), Gaps = 50/440 (11%)
Query: 99 DKKQRPDSDESQYLQ------LLEQHLAGATLFYSYGYDLTNSAQRNEELESSAVS-WEQ 151
+KK+ +S E + L+ LL+ + + +YS YDLTNS QR E W++
Sbjct: 145 NKKKVKESKEKEKLERRLLEELLKMFMDSESFYYSLTYDLTNSVQRQSTGERDGRPLWQK 204
Query: 152 ADRRFFWNYYVTESLQKLAKVDDRVSDFIIPMIYGYAKVVDTVFHATPIS---------- 201
D RFFWN Y+ + L ++ D V +IIPMI G+ ++ + V + T S
Sbjct: 205 VDDRFFWNKYMIQDLTEIGTPD--VDFWIIPMIQGFVQIEELVVNYTESSDDEKSSPETP 262
Query: 202 ---------------IGLITRRSIFRAGTRYFRRGIDEHGNVGNFNETEQVLCVQKPMKD 246
+ LI+RRS RAG RY RRG+D++GNV N+ ETEQ++ V
Sbjct: 263 PQESTCVDDIHPRFLVALISRRSRHRAGMRYKRRGVDKNGNVANYVETEQLIHVHN---- 318
Query: 247 GYHFFSFLQTRGSVPVYWAEXXXXXXXX-XXXXAENSSLDATKKHFDEQTRXXXXXXXXX 305
H SF+QTRGSVPV+W++ +E ++ HF+EQ
Sbjct: 319 --HTLSFVQTRGSVPVFWSQVGYRYNPRPRLDRSEKETVAYFCAHFEEQLNIYKKQVIIN 376
Query: 306 XXXQKGHELPVKEAYEQVVTALNDPKLHYIYFDFHHECRNMQWHKVKLLLDHLQSMGLSN 365
Q G E + +AY + V N+ L Y+ FDFH CR M++ V+ L D + + L
Sbjct: 377 LVDQAGREKIIGDAYLKQVLLFNNSHLTYVSFDFHEHCRGMKFENVQTLTDAIYDIILDM 436
Query: 366 KDFFHKTLDANGVTLQVFSKQQSVVRTNCMDCLDRTNVVQSVLAHWVLQEEFKTVGLTDD 425
K + +D GV KQ+ + R NCMDCLDRTNVVQ+ +A V++++ K +G+
Sbjct: 437 KWCW---VDEAGV----ICKQEGIFRVNCMDCLDRTNVVQAAIARVVMEQQLKKLGVMPP 489
Query: 426 TGLWELDKNLLFEFQSFWADNADAVSVAYSGTGALKTDFTRTGKRTYLGAIKDGINSISR 485
+ N ++ Q WA+N D++S Y+GT ALK DFTRTG+R G +KDG+NS +R
Sbjct: 490 EQPLPVKCNRIY--QIMWANNGDSISRQYAGTAALKGDFTRTGERKLAGVMKDGVNSANR 547
Query: 486 YYQNNLTDGPREDAFDLFLG 505
YY N D R+ DL G
Sbjct: 548 YYLNRFKDAYRQAVIDLMQG 567
>7300754 [I] KOG1890 Phosphoinositide phosphatase SAC1
Length = 987
Score = 231 bits (590), Expect = 2e-60
Identities = 142/387 (36%), Positives = 206/387 (52%), Gaps = 27/387 (6%)
Query: 123 TLFYSYGYDLTNSAQRNEELESSAVSWEQADRRFFWNYYVTESLQKLAKVDDRVSDFIIP 182
+ ++S+ D+TN+ QR+E S S Q D RFFWN ++ ++ L ++D+ +I+P
Sbjct: 204 SFYFSFDCDITNNLQRHEA--KSEESQSQPDERFFWNKHM---IRDLINLNDKT--WILP 256
Query: 183 MIYGYAKVVDTVFHATPISIGLITRRSIFRAGTRYFRRGIDEHGNVGNFNETEQVLCVQK 242
+I G+ +V + V ++ L++RRS RAGTRY RRG+DE GN N+ ETEQ+L +
Sbjct: 257 IIQGFMQVENCVIGNECFTLALVSRRSRHRAGTRYKRRGVDEKGNCANYVETEQILSFR- 315
Query: 243 PMKDGYHFFSFLQTRGSVPVYWAEXXXXXX---XXXXXXAENSSLDATKKHFDEQTRXXX 299
+H SF Q RGSVP+YW++ AE A + HF ++
Sbjct: 316 -----HHQLSFTQVRGSVPIYWSQPGYKYRPPPRLDRGVAETQQ--AFELHFTKELETYG 368
Query: 300 XXXXXXXXXQKGHELPVKEAYEQVVTALNDPKLHYIYFDFHHECRNMQWHKVKLLLDHLQ 359
Q G E + +AY V LN+ +L Y+ FDFH CR M++ V L+D
Sbjct: 369 RVCIVNLVEQSGKEKTIGDAYADHVIKLNNDRLIYVTFDFHDYCRGMRFENVSALID--- 425
Query: 360 SMGLSNKDFFHKTLDANGVTLQVFSKQQSVVRTNCMDCLDRTNVVQSVLAHWVLQEEFKT 419
++G D G+ Q+SV R NCMDCLDRTNVVQ+ + VL+ +
Sbjct: 426 AVGPEAGAMGFHWRDQRGM----ICNQKSVFRVNCMDCLDRTNVVQTAIGKAVLESQLVK 481
Query: 420 VGLTDDTGLWELDKNLLFEFQSFWADNADAVSVAYSGTGALKTDFTRTGKRTYLGAIKDG 479
+GL+ + + L F WA+N D +S Y+GT ALK D+TRTG+R G +KDG
Sbjct: 482 LGLSPP--YTPIPEQLKSPFMVLWANNGDIISRQYAGTNALKGDYTRTGERKISGMMKDG 539
Query: 480 INSISRYYQNNLTDGPREDAFDLFLGN 506
+NS +RYY D R+ DL LGN
Sbjct: 540 MNSANRYYLARFKDSYRQATIDLMLGN 566
>At5g66020 [I] KOG1889 Putative phosphoinositide phosphatase
Length = 549
Score = 229 bits (585), Expect = 7e-60
Identities = 165/534 (30%), Positives = 269/534 (49%), Gaps = 64/534 (11%)
Query: 52 IMKVAALIGIIKLKFGKYVIIANRVEEAGCLNGHNVYKV-------AEHTIISVDKKQRP 104
I + ++G++KL G Y+++ E G GH +YK+ +H++ + ++Q+
Sbjct: 59 IRSIFGVVGMLKLLAGSYLVVVTESESVGSFLGHPIYKINSLKFLPCDHSLENPHEEQKK 118
Query: 105 DSDESQYLQLLEQHLAGATLFYSYGYDLTNSAQRNEEL--ESSAVS-WEQADRRFFWNYY 161
+ Y +LL L++SY +LT +AQR +L ES + W QA+ RF WN Y
Sbjct: 119 -METDDYSRLLSVAERTTGLYFSYEINLTLTAQRLHDLGDESKLLPLWRQAEPRFLWNNY 177
Query: 162 VTESLQKLAKVDDRVSDFIIPMIYGYAKVVDTVFHATPISIGLITRRSIFRAGTRYFRRG 221
+ E L +D+++ F++P+I G +VD I LI RR R GTR +RRG
Sbjct: 178 MLEVL-----IDNKLDQFLLPVIQG--NIVD---------ITLIARRCSRRNGTRMWRRG 221
Query: 222 IDEHGNVGNFNETEQVLCVQKPMKDGYHFFSFLQTRGSVPVYWAEXXXXXXXXXXXXAE- 280
D G V NF ETEQ++ + +GY SF+Q RGS+P W + +
Sbjct: 222 ADPDGYVANFVETEQIVRM-----NGYTS-SFVQIRGSMPFMWEQIVDLTYKPKFEIVQP 275
Query: 281 NSSLDATKKHFDEQTRXXXXXXXXXXXXQKGHELPVKEAYEQVVTALNDPKLHYIYFDFH 340
++ ++HF + + +G Q +TA Y++FDFH
Sbjct: 276 EEAVRIAERHFLDLRKKYGSVLAVDLHGGEGRLSERFAGAMQHITASR-----YLHFDFH 330
Query: 341 HECRNMQWHKVKLLLDHLQSMGLSNKDFFHKTLDANGVTLQVFSKQQSVVRTNCMDCLDR 400
H C ++ + ++ +L + ++ N F L+ G ++ +Q +VRTNC+DCLDR
Sbjct: 331 HICGHIHFERLAILYEQMEDFLEKNGYFL---LNEKGEKMK---EQLGIVRTNCIDCLDR 384
Query: 401 TNVVQSVLAHWVLQEEFKTVGLTDDTGLWELDKNLLFEFQSFWADNADAVSVAYSGTGAL 460
TNV QS++ +L+ + K +G+ +N ++ WA++ D +S+ YSGT AL
Sbjct: 385 TNVTQSMIGRKLLELQLKRIGVFGAEETIRSHQNFDECYKILWANHGDDISIQYSGTPAL 444
Query: 461 KTDFTRTGKRTYLGAIKDGINSISRYYQNNLTDGPREDAFDLFLGNFRPYASVVHSPFPD 520
K DF R G+RT G ++DG N+++RYY NN DG ++DA DL G++ S +P P
Sbjct: 445 KGDFVRYGQRTIQGVLQDGWNALARYYLNNFADGTKQDAIDLVQGHYIVAVSRDMAPVPR 504
Query: 521 RRPMLIQAVPTMIYAALTVMMATILFPKNHFTSAKNLSFFFGSFSI-VVLCTHF 573
+R ++AV ALTV++ +SF+F + S+ VV+ T F
Sbjct: 505 KRG--LEAVAN-FPVALTVIL---------------ISFWFATMSLGVVISTCF 540
>At3g51830 [I] KOG1889 Putative phosphoinositide phosphatase
Length = 599
Score = 210 bits (534), Expect = 6e-54
Identities = 153/537 (28%), Positives = 252/537 (46%), Gaps = 43/537 (8%)
Query: 32 STHENEVNVLGSTEFPVRGNIMKVAALIGI---IKLKFGKYVIIANRVEEAGCLNGHNVY 88
S + + N+ E G+ +V+ + G+ I+L G Y+++ EE G G ++
Sbjct: 38 SVNRRDGNIKPLDENASSGSPTRVSTIYGVGGTIRLLAGTYLLVITSREEVGNFLGLPIF 97
Query: 89 KVAEHTIISVDKKQR-----PDSDESQYLQLLEQHLAGATLFYSYGYDLTNSAQRNEELE 143
+V + ++ R DE+ + LL+ L++SY DLT + QR +L
Sbjct: 98 RVTAMKFLPCNEALRFATAQEKKDETYFRTLLQALETTPGLYFSYETDLTLNLQRRCKLA 157
Query: 144 SS---AVSWEQA--------DRRFFWNYYVTESLQKLAKVDDRVSDFIIPMIYGYAKVVD 192
W+QA D R+ WN+++ E L + V + F I Y +V +
Sbjct: 158 EGWNRKPMWKQAEGLFACQADPRYVWNWHLLEDLIECKTVLQYML-FDINQGLSY-QVAE 215
Query: 193 TVFHATPISIGLITRRSIFRAGTRYFRRGIDEHGNVGNFNETEQVLCVQKPMKDGYHFFS 252
+P + +++RR R GTR +RRG + G+ NF E+EQ++ + +G+ F S
Sbjct: 216 LKLKNSPAVVSIMSRRCTRRLGTRMWRRGANLEGDAANFVESEQIVEI-----NGFKF-S 269
Query: 253 FLQTRGSVPVYWAEXXXXXXXXXXXXAENSSLD-ATKKHFDEQTRXXXXXXXXXXXXQKG 311
LQ RGS+P+ W + ++ ++HF + + Q G
Sbjct: 270 LLQVRGSIPLLWEQIVDLSYKPRLKINKHEETPKVVQRHFHDLCQRYGEIMAVDLTDQHG 329
Query: 312 HELPVKEAYEQVVTALNDPKLHYIYFDFHHECRNMQWHKVKLLLDHLQSMGLSNKDFFHK 371
E + +AY + L P + Y+ FDFH C + + +L + + + +F
Sbjct: 330 DEGALSKAYATEMEKL--PDVRYVSFDFHQVCGTTNFDNLGVLYEQIGDE-FEKQGYFLV 386
Query: 372 TLDANGVTLQVFSKQQSVVRTNCMDCLDRTNVVQSVLAHWVLQEEFKTVGLTDDTGLWEL 431
D N + +Q+ V+R+NC+DCLDRTNV QS + L + + +G+ D T
Sbjct: 387 DADEN-----ILEEQKGVIRSNCIDCLDRTNVTQSFMGQKSLNLQLQRIGVCDSTECIST 441
Query: 432 DKNLLFEFQSFWADNADAVSVAYSGTGALKTDFTRTGKRTYLGAIKDGINSISRYYQNNL 491
++ +F++ WA+ D VS+ Y+GT ALK D R GK+T GAIKDG++++SRYY NN
Sbjct: 442 FEDDYTKFRTIWAEQGDEVSLQYAGTYALKGDLVRYGKQTMTGAIKDGLSAMSRYYLNNF 501
Query: 492 TDGPREDAFDLFLGNFRPYASVVHSPFP----DRRPMLIQAVPTMIYAALTVMMATI 544
DG R+DA DL G Y HSP +P + ++ +TV TI
Sbjct: 502 QDGVRQDALDLISGR---YTVGTHSPSQLQPIGSQPSFLPVASALLIGGVTVTSFTI 555
>At3g51460 [I] KOG1889 Putative phosphoinositide phosphatase
Length = 603
Score = 199 bits (505), Expect = 1e-50
Identities = 154/550 (28%), Positives = 250/550 (45%), Gaps = 86/550 (15%)
Query: 52 IMKVAALIGIIKLKFGKYVIIANRVEEAGCLNGHNVYKVAEHTIISVDK--KQRPDSD-- 107
I + ++G++KL G Y+++ E G GH ++KV ++ D K P+
Sbjct: 62 IRSIFGVVGMLKLLAGSYLVVVTESERVGSFLGHPIFKVTTLKVLPCDHSLKNSPEEQKK 121
Query: 108 -ESQYLQLLEQHLAGATLFYSYGYDLTNSAQRNEELESSAVS---WEQADRRFFWNYYVT 163
E+++ +LL L++SY +LT S+QR E+ + S W QA+ RF WN Y+
Sbjct: 122 METEFSKLLSVAEKTTGLYFSYEVNLTLSSQRLHEMGDESKSLPLWRQAEPRFLWNNYML 181
Query: 164 ESLQKLAKVDDRVSDFIIPMIYGYA---KVVDTVFHATPISIGLITRRS----------- 209
E L +D+++ F++P+I G + +T + I LI RR
Sbjct: 182 EVL-----IDNKLDQFLLPVIQGNILCYQFFETAIGRDIVDITLIARRCTRRNERYMSLP 236
Query: 210 -------------------IFRAGTRYFRRGIDEHGNVGNFNETEQVLCVQKPMKDGYHF 250
I GTR +RRG D G V NF ETEQ++ +GY
Sbjct: 237 AGNLNAEYCVVNVSSPLSWIVLQGTRMWRRGADLDGYVANFVETEQIV-----QMNGY-T 290
Query: 251 FSFLQTRGSVPVYWAEXXXXXXXXXXXXAE-NSSLDATKKHFDEQTRXXXXXXXXXXXXQ 309
SF+Q RGS+P W + + + ++HF + + +
Sbjct: 291 SSFVQVRGSMPFMWEQVVDLTYKPKFEIVQPEEAKRIAERHFLDLRKKYGSVLAVDLVNK 350
Query: 310 KGHELPVKEAYEQVVTALNDPKLHYIYFDFHHECRNMQWHKVKLLLDHLQSMGLSNKDFF 369
+G E + E Y V+ + + Y++FDFH C ++ + ++ +L + ++ L +F
Sbjct: 351 QGGEGRLCEKYATVMQHITGDDIRYLHFDFHQICGHIHFERLSILYEQIEGF-LEKNGYF 409
Query: 370 HKTLDANGVTLQVFSKQQSVVRTNCMDCLDRTNVVQ--------SVLAHWVLQEEFKTVG 421
L+ G + +Q VVR+NC+DCLDRTNV Q ++++W L +
Sbjct: 410 --LLNEKG---EKMKEQLGVVRSNCIDCLDRTNVTQVSHKKTMMQLISYWPL-----LIH 459
Query: 422 LTDDTGLWELDKNLLFEFQSFWADNADAVSVAYSGTGALKTDFTR---------TGKRTY 472
E D++ + WA++ D +S+ YSGT ALK DF R G RT
Sbjct: 460 AAYFLPNAEHDRS---KDVRIWANHGDEISIQYSGTPALKGDFVRYFCHMFNLGYGHRTA 516
Query: 473 LGAIKDGINSISRYYQNNLTDGPREDAFDLFLGNFRPYASVVHSPFPDRRPMLIQAVPTM 532
G +KDG +S+ RYY NN DG ++DA DL G++ S +P P + ++AV
Sbjct: 517 HGVLKDGWSSLRRYYLNNFADGTKQDAIDLLQGHYIVAVSRDMAPVPQKGG--LEAVANF 574
Query: 533 IYAALTVMMA 542
A V+M+
Sbjct: 575 PVALFVVLMS 584
>CE20170 [I] KOG1890 Phosphoinositide phosphatase SAC1
Length = 783
Score = 194 bits (494), Expect = 3e-49
Identities = 130/391 (33%), Positives = 202/391 (51%), Gaps = 37/391 (9%)
Query: 125 FYSYGYDLTNSAQRNEELESSAVSWEQADRRFFWNYYVTESLQKLAKVDDRVSDFIIPMI 184
++ D+T S+Q+ E + S + FFWN + +L + AK+ D+ F P++
Sbjct: 156 YFCRSRDVTISSQKYFEKREAHTSEDS----FFWNKRMVGNLGE-AKISDK---FTCPIM 207
Query: 185 YGYA-----KVVDTVFHATPISIGLITRRSIFRAGTRYFRRGIDEHGNVGNFNETEQVLC 239
GY ++ D + ++I +I+RRS RAG RY RRGIDE NV NF ETE +L
Sbjct: 208 QGYVATSQLEITDQI--NAYLTITIISRRSTRRAGARYLRRGIDEASNVANFVETELILN 265
Query: 240 VQKPMKDGYHFFSFLQTRGSVPVYWAEXXXXXXXXXXXXAENSSLDATKKHFDEQTRXXX 299
+ + H SF+Q RGS+PV+W++ N S++ T F E +
Sbjct: 266 IFE------HELSFVQCRGSIPVFWSQRGFKYRPPLII---NRSVEETHGVFTEHFKRLK 316
Query: 300 XXXXX-----XXXXQKGHELPVKEAYEQVVTALNDPKLHYIYFDFHHECRNMQWHKVKLL 354
Q+G ELP+ + + + +D + + FD H CR + + K++ L
Sbjct: 317 AHYDTPLVAVSLVDQRGRELPLAQRFLEHCVKADDNDVTFFSFDLHQHCRGLNFQKLQTL 376
Query: 355 LDHLQSMGLSNKDFFHKTLDANGVTLQVFSKQQSVVRTNCMDCLDRTNVVQSVLAHWVLQ 414
+ SM + K +D G +V Q+ VVRTNC+DCLDRTN+VQ ++ +V+
Sbjct: 377 IS---SMEETLKTIGFCWVDKTG---EVVQSQKGVVRTNCIDCLDRTNLVQGQISLFVVL 430
Query: 415 EEFKTVGLTDDTGLWELDKNLLFEFQSFWADNADAVSVAYSGTGALKTDFTRTGKRTYLG 474
++ + +G+ L E + L+ Q+ WADN D +S Y+GT ALK D TR G+R +G
Sbjct: 431 QQAQRLGIFGP--LCEPPEVLVQTMQTMWADNGDVISTQYAGTAALKGDVTRNGERKLMG 488
Query: 475 AIKDGINSISRYYQNNLTDGPREDAFDLFLG 505
+KDG NS SRYY + D R+ A ++ G
Sbjct: 489 VMKDGYNSASRYYLTHTKDAQRQKAINIVTG 519
>YNL106c [U] KOG0566 Inositol-145-triphosphate 5-phosphatase (synaptojanin)
INP51/INP52/INP53 family
Length = 1183
Score = 174 bits (441), Expect = 4e-43
Identities = 123/467 (26%), Positives = 216/467 (45%), Gaps = 48/467 (10%)
Query: 115 LEQHLAGATLFYSYGYDLTNSAQRNEELESSAVSWEQADRRFFWNYYVTESL----QKLA 170
L + L+ + +YS +DLT + Q+ E S +S++ DR F WN ++ + + +L
Sbjct: 167 LRKLLSNGSFYYSTDFDLTCTLQKRGFTEHS-LSFDDFDREFMWNSFLMDEIITYRDRLD 225
Query: 171 KVDDRVSD---FIIPMIYGYAKVVDTVFHATPISIGLITRRSIFRAGTRYFRRGIDEHGN 227
+ D F+ +I G+A+ + + + + + +I+R+S RAGTR+ RGID+ G+
Sbjct: 226 VTAKELLDQRGFLTTVIRGFAETIFSYINRLKVGLTIISRQSWKRAGTRFNARGIDDDGH 285
Query: 228 VGNFNETEQVLCVQKPMKDGYHFFSFLQTRGSVPVYWAEXXXXXXXXXXXXAENSSLDAT 287
V NF ETE + M + ++F Q RGS+P++W + S++AT
Sbjct: 286 VANFVETEMI------MYSSQYCYAFTQIRGSLPIFWEQDTSLISPKIQITR---SVEAT 336
Query: 288 KKHFDEQT----RXXXXXXXXXXXXQKGHELPVKEAYEQVVTALNDPKL----HYIYFDF 339
+ FDE + K E+ + Y++ + K+ FDF
Sbjct: 337 QPTFDEHFIRLFKKYGPVHIINLLSTKSSEIQLSRRYKEQLKNSEKMKIGRDVFLTSFDF 396
Query: 340 HHECRNMQWHKVKLLLDHLQSMGLSNKDFFHKTLDANGVTLQVFSKQQSVVRTNCMDCLD 399
H E + ++ +++ L F + + ++ S+Q V RTNC+DCLD
Sbjct: 397 HRETSQDGFAAASRIIPKIRNTILDAGYFSYDVKEG-----RLISEQDGVFRTNCLDCLD 451
Query: 400 RTNVVQSVLAHWVLQEEFKTVGLTDDTGLWELDKNLLFEFQSFWADNADAVSVAYSGTGA 459
RTN++Q ++ V + + L + + D + + + WADN D +S Y+GT A
Sbjct: 452 RTNLIQQTISLAVFKLFLEDFRLVKPSSFID-DNEFVQKVNALWADNGDQISQIYTGTNA 510
Query: 460 LKTDFTRTGKRTYLGAIKDGINSISRYYQNNLTDGPREDAFDLFLGNFRPYASVVHSPFP 519
LK+ ++R GK ++ GA+ D S+SR Y NN D ++ D LG P+ VV P
Sbjct: 511 LKSSYSRKGKMSFSGALSDATKSVSRMYINNFVDKGKQQNIDTLLGKL-PHQQVVELYDP 569
Query: 520 DRRPMLIQAVPTMIYAALTVMMATILFPKNHFTSAKNLSFFFGSFSI 566
+ +L + FT+ N++ F G+F++
Sbjct: 570 ----------------ICEYVNERLLESEEKFTTHSNINLFVGTFNV 600
>YOR109w [U] KOG0566 Inositol-145-triphosphate 5-phosphatase (synaptojanin)
INP51/INP52/INP53 family
Length = 1107
Score = 169 bits (429), Expect = 9e-42
Identities = 130/493 (26%), Positives = 221/493 (44%), Gaps = 70/493 (14%)
Query: 104 PDSDESQYLQLLEQH--------LAGATLFYSYGYDLTNSAQRNEELESSAVSWEQADRR 155
P++ ++Y L +H L+ + +YS +DLT++ Q + S +S + +
Sbjct: 123 PETASTEYQDALPKHPCYELKKLLSNGSFYYSSDFDLTSTLQHRGYGQHS-LSTDTYEEE 181
Query: 156 FFWNYYVTESL--------QKLAKVDDRVSDFIIPMIYGYAKVVDTVFHATPISIGLITR 207
+ WN ++ + + L ++ D F+ +I G+A+ + +++ +I++
Sbjct: 182 YMWNSFLMQEMITYRDHLDTNLKQILDD-EGFLTTVIRGFAETFVSYVKKLKVALTIISK 240
Query: 208 RSIFRAGTRYFRRGIDEHGNVGNFNETEQVLCVQKPMKDGYHFFSFLQTRGSVPVYWAEX 267
+S RAGTR+ RG+D+ NV NF ETE + M + ++F Q RGS+PV+W +
Sbjct: 241 QSWKRAGTRFNARGVDDEANVANFVETEFI------MYSSQYCYAFTQIRGSIPVFWEQG 294
Query: 268 XXXXXXXXXXXAENSSLDATK----KHFDEQTRXXXXXXXXXXXXQKGHELPVKEAYEQV 323
S +AT+ KH + K E+ + + Y++
Sbjct: 295 TSLINPRVQITR---SFEATQPVFDKHIMKSVEKYGPVHVVNLLSTKSSEIELSKRYKEH 351
Query: 324 VTALNDPKLHY------IYFDFHHECRNMQWHKVK----LLLDHLQSMGLSNKDFFHKTL 373
+T + KL++ FDFH E + V+ L+LD L S G + D K
Sbjct: 352 LT--HSKKLNFNKDIFLTEFDFHKETSQEGFSGVRKLIPLILDSLLSSGYYSYDVREK-- 407
Query: 374 DANGVTLQVFSKQQSVVRTNCMDCLDRTNVVQSVLAHWVLQEEFKTVGLTDDTGLWELDK 433
+ S+Q + RTNC+DCLDRTN+ Q +++ + + L + D
Sbjct: 408 -------KNISEQHGIFRTNCLDCLDRTNLAQQIISLAAFRTFLEDFRLISSNSFID-DD 459
Query: 434 NLLFEFQSFWADNADAVSVAYSGTGALKTDFTRTGKRTYLGAIKDGINSISRYYQNNLTD 493
+ + + + WAD+ D +S Y+GT ALK+ F+R GK + GA+ D S+SR Y NN D
Sbjct: 460 DFVSKHNTLWADHGDQISQIYTGTNALKSSFSRKGKMSLAGALSDATKSVSRIYINNFMD 519
Query: 494 GPREDAFDLFLGNFRPYASVVHSPFPDRRPMLIQAVPTMIYAALTVMMATILFPKNHFTS 553
++ D LG PY V L V + L M + FTS
Sbjct: 520 KEKQQNIDTLLGRL-PYQKAV---------QLYDPVNEYVSTKLQSM-------SDKFTS 562
Query: 554 AKNLSFFFGSFSI 566
N++ GSF++
Sbjct: 563 TSNINLLIGSFNV 575
>SPBC2G2.02 [U] KOG0566 Inositol-145-triphosphate 5-phosphatase (synaptojanin)
INP51/INP52/INP53 family
Length = 1076
Score = 166 bits (419), Expect = 1e-40
Identities = 149/605 (24%), Positives = 254/605 (41%), Gaps = 93/605 (15%)
Query: 6 LVCQEKDRVLLKVASSSSKNDAVLNVSTHENEVNVLGSTEFPVRG----NIMKVAALIGI 61
L KD L+ + +KN + V+ E L +E P+ G + ++ +G+
Sbjct: 12 LALVNKDHALMFHSVPQNKNSLSVCVA----EFTAL--SEKPLEGFRKISSHRIYGTLGL 65
Query: 62 IKLKFGKYV-IIANRVEEAGCLNGHNVYKVAEHTIISVDKKQRP---------------D 105
I+L+ ++ +I+ E A + V+++ E SV++ D
Sbjct: 66 IELEGSNFLCVISGASEVARVRDKERVFRIMEVCFYSVNRSNWDHIRQENYSPDIPDGYD 125
Query: 106 SDESQY---------LQLLEQHLAGATLFYSYGYDLTNSAQRNEELESSAVSWEQADRRF 156
+D Y L + L + ++S +D+T Q + ++ +F
Sbjct: 126 TDTQGYDSYKYAAEPFSSLRKLLTNGSFYFSLDFDITTRLQLRTSQTMTEPQYDSMHTQF 185
Query: 157 FWNYYVTESLQKLAKV---DDRVS----DFIIPMIYGYAKVVDTVFHATPISIGLITRRS 209
WN ++ L K D++ + F I G+A I + LI+R S
Sbjct: 186 MWNEFMLRQLIKFRSHLNGDEKSALDGCRFFTCAIRGFASTEQFKLGIQTIRLSLISRLS 245
Query: 210 IFRAGTRYFRRGIDEHGNVGNFNETEQVLCVQKPMKDGYHFFSFLQTRGSVPVYWAEXXX 269
RAGTR+ RG+D+ GNV NF ETE +L K + S+ Q RGS+P++W +
Sbjct: 246 SLRAGTRFLSRGVDDDGNVANFVETETILDSSK------YCVSYCQVRGSIPIFWEQEGV 299
Query: 270 XXXXXXXXXAENSSLDATK----KHFDEQTRXXXXXXXXXXXXQKGHELPVKEAYEQVVT 325
SL+AT+ KHF E + E Q +
Sbjct: 300 QMFGQKIDITR--SLEATRAAFEKHFTSLIEEYGPVHIINLLGTGSGERSLSERLRQHIQ 357
Query: 326 ALNDPKL-HYIYFDFHHECRNMQ-WHKVK-LLLDHLQSMGLSNKDFFHKTLDANGVTLQV 382
+ L H FD+H + R+ + +K++ ++ ++ G F+ + + + +Q
Sbjct: 358 LSPEKDLIHLTEFDYHSQIRSFEDANKIRPMIYSDAETFG-----FYFENNEGQSIVVQ- 411
Query: 383 FSKQQSVVRTNCMDCLDRTNVVQSVLAHWVLQEEFKTVGLTDDTGLWELDKNLLFEFQSF 442
V RTNC+DCLDRTNV+Q++++ L++ W++ +
Sbjct: 412 ----DGVFRTNCLDCLDRTNVIQNLVSRVFLEQVMIYTRQNAGYDFWQVHSTI------- 460
Query: 443 WADNADAVSVAYSGTGALKTDFTRTGKRTYLGAIKDGINSISRYYQNNLTDGPREDAFDL 502
WA+N DA++ Y+GTGALK+ FTR GK + GA+ D S+ R Y NN D R++ DL
Sbjct: 461 WANNGDALARIYTGTGALKSSFTRKGKLSIAGALNDLSKSVGRMYINNFQDKGRQETIDL 520
Query: 503 FLGNFRPYASVVHSPFPDRRPMLIQAVPTMIYAALTVMMATILFPK-NHFTSAKNLSFFF 561
LG LI P ++Y + + L + N F+ KN+ F
Sbjct: 521 LLGR------------------LIDQHPVILYDPIHEYVNHELRKRENEFSEHKNVKIFV 562
Query: 562 GSFSI 566
S+++
Sbjct: 563 ASYNL 567
>YNL325c [I] KOG1888 Putative phosphoinositide phosphatase
Length = 879
Score = 164 bits (415), Expect = 4e-40
Identities = 138/517 (26%), Positives = 221/517 (42%), Gaps = 50/517 (9%)
Query: 30 NVSTHENEV-NVLGSTEFPVRGNIMKVAA---LIGIIKLKFGKYVIIANRVEEAGCLNGH 85
NV NE+ NVL S E + K L+G IK Y+I+ + + + GH
Sbjct: 74 NVFFTRNEIMNVLASLEEATEDGLHKKITGYGLLGFIKFTCWYYLIMVTKYSQVAVIGGH 133
Query: 86 NVYKVAEHTIISVD---KKQRPDSDESQYLQLLEQHLAGATLFYSYGYDLTNSAQRNEEL 142
+Y + II + KK SDE++ L + + T ++SY YD+TN+ Q N L
Sbjct: 134 GIYHIDGIDIIPITNNYKKPEKSSDEARLLNIFKDLDLTKTFYFSYTYDITNTLQTNI-L 192
Query: 143 ESSAVSWEQAD-----------RRFFWNYYVTESLQKLAKVDDRVSDFIIPMIYGYAKVV 191
+ ++ D F WN L + D V D+ +I+G+ V
Sbjct: 193 REKLKAVDRCDITIPCGITDYNEMFVWN---NNLLSPIFACIDTVFDWFQCIIHGFIDQV 249
Query: 192 DTVFHATPISIGLITRRSIFRAGTRYFRRGIDEHGNVGNFNETEQVLC--VQKPMK---- 245
+ I I LI RRS AG R+ +RG++ G+V N ETEQ++ + P
Sbjct: 250 NVSVLGKSIYITLIARRSHHFAGARFLKRGVNNKGHVANEVETEQIVTDMILTPFHQPGN 309
Query: 246 ---DGYHFFSFLQTRGSVPVYWAEXXXXXXXX--XXXXAENSSLDATKKHFDEQTRXXXX 300
D + SF+Q RGS+P+YW + + HFD +
Sbjct: 310 GFFDSDRYTSFVQHRGSIPLYWTQDASNLTTKPPIRINVVDPFFSPAALHFDNLFQRYGG 369
Query: 301 XXXXXXXXQKGHELPVKEA-----YEQVVTALND-----PKLHYIYFDFHHECRNMQWHK 350
K E +E +EQ + LN+ KL Y +D +
Sbjct: 370 GTIQILNLIKTKEKTPRETKLLWEFEQCIDYLNEFLPTLKKLDYTSWDMSRASKQDGQGV 429
Query: 351 VKLLLDHLQSMGLSNKDFFHKTLDANGVTLQVFSKQQSVVRTNCMDCLDRTNVVQSVLAH 410
++ L + + ++ FH NG Q+ + R+NC+DCLDRTN Q V+
Sbjct: 430 IEFLEKYAVNT-VTTTGIFH-----NGPDFASTKIQEGICRSNCIDCLDRTNAAQFVIGK 483
Query: 411 WVLQEEFKTVGLTDDTGLWELDKNLLFEFQSFWADNADAVSVAYSGTGALKTDFTRTGKR 470
L + K++G+ D++ L E D +++ + D D +++ Y G+ + T T
Sbjct: 484 RALGCQLKSLGIIDNSYL-EYDSDIVNILTELFHDLGDTIALQYGGSHLVNTMETYRKIN 542
Query: 471 TYLGAIKDGINSISRYYQNNLTDGPREDAFDLFLGNF 507
+ +D I SI R+Y N+ D R+DA +LFLG++
Sbjct: 543 QWSSHSRDMIESIKRFYSNSFVDAQRQDAINLFLGHY 579
>CE08566 [I] KOG1888 Putative phosphoinositide phosphatase
Length = 921
Score = 158 bits (399), Expect = 3e-38
Identities = 128/491 (26%), Positives = 216/491 (43%), Gaps = 45/491 (9%)
Query: 58 LIGIIKLKFGKYVIIANRVEEAGCLNGHNVYKVAEHTIISVDKKQ-RPDSDESQYLQLLE 116
++G ++ G Y+II R L H VYK+ E +I + S+E +Y++L +
Sbjct: 93 ILGCVRFVEGYYLIIITRAHAVATLGYHPVYKIVEVAMIPIAMDGVSTSSEEQKYVKLFQ 152
Query: 117 QHLAGATLFYSYGYDLTNSAQRNE---ELESSAVSWEQADRRFFWNYYVTESLQKLAKVD 173
++SY YD++ + Q N + + +AD RF WN ++ E L+K +
Sbjct: 153 SVDLSTDFYFSYSYDMSRTFQENSLRSDWNNHGQRRLEADERFVWNSFLLEPLRKNL-IS 211
Query: 174 DRVSDFIIPMIYGYAKVVDTVFHATPISIGLITRRSIFRAGTRYFRRGIDEHGNVGNFNE 233
+R + + +++GY + IS+ +I RRS AGTR+ +RG + GNV N+ E
Sbjct: 212 ER---WFVEIVHGYVRQEYIFLPIGRISLTIIGRRSTKYAGTRFLKRGANPTGNVANYVE 268
Query: 234 TEQV---LCVQKPMKDGYHFFSFLQTRGSVPVYWAEXXXXXXX----XXXXXAENSSLDA 286
TEQ+ + + DG F SF+Q RGSVP+ W++
Sbjct: 269 TEQIVWDMASSGNVADG-RFSSFVQMRGSVPMRWSQDPSTRGVVGKPLILIDNHEPHAQT 327
Query: 287 TKKHF----DEQTRXXXXXXXXXXXXQKGHELPVKEAYEQVVTAL-----NDPKLHYIYF 337
HF ++ ++ HE + + + + L N+ KL YI F
Sbjct: 328 AASHFRDVRNKYGNPIVIMNLIKRNEKRRHEGVLHTQFLKNIEYLNQFLPNEEKLCYISF 387
Query: 338 DF---HHECRNMQWHKVKLLLDHLQSMGLSNKDFFHK----------------TLDANGV 378
D + +M V +++ L + +F TLDA+
Sbjct: 388 DVARCNKAANSMPSINVLNVMEDLSMKSILKNGWFQSFPLSEALKIRPREAFATLDAHHS 447
Query: 379 TLQVFSKQQSVVRTNCMDCLDRTNVVQSVLAHWVLQEEFKTVGLTDDTGLWELDKNLLFE 438
F Q + RTNC+DCLDRTNV Q V+A L + +G+ D+ L L +
Sbjct: 448 KDGRFMIQHGICRTNCVDCLDRTNVAQFVIAKVALGCQLCAMGILDEPNL-TLQSEVCRL 506
Query: 439 FQSFWADNADAVSVAYSGTGALKTDFTRTGKRTYLGAIKDGINSISRYYQNNLTDGPRED 498
+ + ++ D +++ Y+G+ + + T + +D ++SRYY N D ++
Sbjct: 507 LEDMFDEHGDTMALQYAGSQLVHSIKTYKKTAAFQERRRDVFQTLSRYYSNTFNDWDKQM 566
Query: 499 AFDLFLGNFRP 509
A +LFLG FRP
Sbjct: 567 AINLFLGVFRP 577
>Hs7662034 [I] KOG1888 Putative phosphoinositide phosphatase
Length = 907
Score = 157 bits (397), Expect = 5e-38
Identities = 128/522 (24%), Positives = 223/522 (42%), Gaps = 74/522 (14%)
Query: 58 LIGIIKLKFGKYVIIANRVEEAGCLNGHNVYKVAEHTIISV--DKKQRPDSDESQYLQLL 115
++G ++ G Y+++ + + + GH +YKV + +I + D + DE++YL++
Sbjct: 95 VVGFVRFLEGYYIVLITKRRKMADIGGHAIYKVEDTNMIYIPNDSVRVTHPDEARYLRIF 154
Query: 116 EQHLAGATLFYSYGYDLTNSAQRN--------EELESSAVSWEQAD-------------- 153
+ + ++SY YDL++S Q N E L+S Q
Sbjct: 155 QNVDLSSNFYFSYSYDLSHSLQYNLTVLRMPLEMLKSEMTQNRQESFDIFEDEGLITQGG 214
Query: 154 -----------RRFFWNYYVTESLQKLAKVDDRVSDFIIPMIYGYAKVVDTVFHATPISI 202
++ WN + + ++ D+++ +I+G+ + + P+ +
Sbjct: 215 SGVFGICSEPYMKYVWNGELLDIIKSTVH-----RDWLLYIIHGFCGQSKLLIYGRPVYV 269
Query: 203 GLITRRSIFRAGTRYFRRGIDEHGNVGNFNETEQVLCVQKPMK-DGYHFFSFLQTRGSVP 261
LI RRS AGTR+ +RG + G+V N ETEQ+LC M + S++Q RGSVP
Sbjct: 270 TLIARRSSKFAGTRFLKRGANCEGDVANEVETEQILCDASVMSFTAGSYSSYVQVRGSVP 329
Query: 262 VYWAEXXXXXXXXXXXXAENSS--LDATKKHFDEQTRXXXX----XXXXXXXXQKGHELP 315
+YW++ + + HFD+ + ++ HE
Sbjct: 330 LYWSQDISTMMPKPPITLDQADPFAHVAALHFDQMFQRFGSPIIILNLVKEREKRKHERI 389
Query: 316 VKEAYEQVVTALND--PKLH---YIYFDFHHECRNMQWHKVKLLLDHLQSMG---LSNKD 367
+ E VT LN P H YI +D ++ K+ +LD L + +
Sbjct: 390 LSEELVAAVTYLNQFLPPEHTIVYIPWDMAKYTKS----KLCNVLDRLNVIAESVVKKTG 445
Query: 368 FF--------------HKTLDANGVTLQVFSKQQSVVRTNCMDCLDRTNVVQSVLAHWVL 413
FF K + G + Q ++RTNC+DCLDRTN Q ++ L
Sbjct: 446 FFVNRPDSYCSILRPDEKWNELGGCVIPTGRLQTGILRTNCVDCLDRTNTAQFMVGKCAL 505
Query: 414 QEEFKTVGLTDDTGLWELDKNLLFEFQSFWADNADAVSVAYSGTGALKTDFTRTGKRTYL 473
+ ++GL D L + D + + F+ + D+ D +S+ Y G+ + T +
Sbjct: 506 AYQLYSLGLIDKPNL-QFDTDAVRLFEELYEDHGDTLSLQYGGSQLVHRVKTYRKIAPWT 564
Query: 474 GAIKDGINSISRYYQNNLTDGPREDAFDLFLGNFRPYASVVH 515
KD + ++SRYY N +D R+D+ +LFLG F P H
Sbjct: 565 QHSKDIMQTLSRYYSNAFSDADRQDSINLFLGVFHPTEGKPH 606
>CE29050 [U] KOG0566 Inositol-145-triphosphate 5-phosphatase (synaptojanin)
INP51/INP52/INP53 family
Length = 1119
Score = 150 bits (380), Expect = 4e-36
Identities = 128/459 (27%), Positives = 213/459 (45%), Gaps = 44/459 (9%)
Query: 52 IMKVAALIGIIKLKFGKYVIIA-NRVEEAGCLNGHNVYKVAEHTIISVDKKQRPDSDESQ 110
I+ ++G++ + + V++A V G L G ++ K+ IS+ ++ +S+
Sbjct: 56 IVDAYGILGVLAITKDEAVLVAVTGVLSVGQLYGADILKITNVEFISLRTFGSVENVDSR 115
Query: 111 YLQLLEQHLAGATLFYS---YGYDLTNSAQRNEELESSAVSWEQADRRFFWNYYVTESLQ 167
+ L Q L + +FY YDLT SAQ + + S D RFFWN + S Q
Sbjct: 116 IIDL--QRLLSSQMFYFSSLQSYDLTRSAQHRDSHDCS-------DARFFWNRSLHFSFQ 166
Query: 168 KLAKVDDRVSDFIIPMIYGYAKVVDTVFHATPISIGLITRRSIFRAGTRYFRRGIDEHGN 227
+ D ++++ + G V A + LI+R S R GTR+ RG + GN
Sbjct: 167 RYGIDTD---NWLLKCMAGSVLVRVVYVGANTGRVALISRLSCERVGTRFNVRGANYLGN 223
Query: 228 VGNFNETEQVLCVQKPMKDGYHFFSFLQTRGSVPVYWAE-XXXXXXXXXXXXAENSSLDA 286
V NF ETEQ+L + S LQ RGS+P++W + A +SL A
Sbjct: 224 VANFVETEQLLLFDEKE------CSLLQIRGSIPLFWEQPGVNVGSHKVKLRAFETSLPA 277
Query: 287 TKKHFDEQTRXXXXXXXXXXXXQKGHELPVKEAYE-QVVTALNDPKLHYIYFDFHHECRN 345
+H + +K E + +A++ Q ++ P + +I FD+H + +
Sbjct: 278 YHRHLSQLQHRYGEFAIVNLLGRKEGERVLGDAFKTQHKSSHFAPLVDFIDFDYHAQMKI 337
Query: 346 MQWHKVKLLLDHLQSMGLSNKDFFHKTLDANGVTLQVFSKQQSVVRTNCMDCLDRTNVVQ 405
+ V+L S ++ FF+ + ++ +Q V+RTNC+DCLDRTN VQ
Sbjct: 338 SKEAIVQL--KKKMSPHMTKHGFFYS------MGKEIVKRQTGVIRTNCLDCLDRTNAVQ 389
Query: 406 SVLAHWVLQEEFKTVGLTDDTGLWELDKNLLFEFQSFWADNADAVSVAYSGTGALKTDFT 465
+ + + ++ + L + G +++ + + W N D S Y+GTGAL
Sbjct: 390 TAIGLQMSHDQVAFLNL--NAGKVNVEQRVEEILRDLWQKNGDQCSTIYAGTGAL----- 442
Query: 466 RTGKRTYLGAIKDGINSISRYYQNNLTDGPREDAFDLFL 504
GK +KD S++R QNNL DG ++++FDLFL
Sbjct: 443 -DGK----SKLKDASRSLARTIQNNLMDGAKQESFDLFL 476
>CE28239 [U] KOG0566 Inositol-145-triphosphate 5-phosphatase (synaptojanin)
INP51/INP52/INP53 family
Length = 1113
Score = 150 bits (380), Expect = 4e-36
Identities = 128/459 (27%), Positives = 213/459 (45%), Gaps = 44/459 (9%)
Query: 52 IMKVAALIGIIKLKFGKYVIIA-NRVEEAGCLNGHNVYKVAEHTIISVDKKQRPDSDESQ 110
I+ ++G++ + + V++A V G L G ++ K+ IS+ ++ +S+
Sbjct: 56 IVDAYGILGVLAITKDEAVLVAVTGVLSVGQLYGADILKITNVEFISLRTFGSVENVDSR 115
Query: 111 YLQLLEQHLAGATLFYS---YGYDLTNSAQRNEELESSAVSWEQADRRFFWNYYVTESLQ 167
+ L Q L + +FY YDLT SAQ + + S D RFFWN + S Q
Sbjct: 116 IIDL--QRLLSSQMFYFSSLQSYDLTRSAQHRDSHDCS-------DARFFWNRSLHFSFQ 166
Query: 168 KLAKVDDRVSDFIIPMIYGYAKVVDTVFHATPISIGLITRRSIFRAGTRYFRRGIDEHGN 227
+ D ++++ + G V A + LI+R S R GTR+ RG + GN
Sbjct: 167 RYGIDTD---NWLLKCMAGSVLVRVVYVGANTGRVALISRLSCERVGTRFNVRGANYLGN 223
Query: 228 VGNFNETEQVLCVQKPMKDGYHFFSFLQTRGSVPVYWAE-XXXXXXXXXXXXAENSSLDA 286
V NF ETEQ+L + S LQ RGS+P++W + A +SL A
Sbjct: 224 VANFVETEQLLLFDEKE------CSLLQIRGSIPLFWEQPGVNVGSHKVKLRAFETSLPA 277
Query: 287 TKKHFDEQTRXXXXXXXXXXXXQKGHELPVKEAYE-QVVTALNDPKLHYIYFDFHHECRN 345
+H + +K E + +A++ Q ++ P + +I FD+H + +
Sbjct: 278 YHRHLSQLQHRYGEFAIVNLLGRKEGERVLGDAFKTQHKSSHFAPLVDFIDFDYHAQMKI 337
Query: 346 MQWHKVKLLLDHLQSMGLSNKDFFHKTLDANGVTLQVFSKQQSVVRTNCMDCLDRTNVVQ 405
+ V+L S ++ FF+ + ++ +Q V+RTNC+DCLDRTN VQ
Sbjct: 338 SKEAIVQL--KKKMSPHMTKHGFFYS------MGKEIVKRQTGVIRTNCLDCLDRTNAVQ 389
Query: 406 SVLAHWVLQEEFKTVGLTDDTGLWELDKNLLFEFQSFWADNADAVSVAYSGTGALKTDFT 465
+ + + ++ + L + G +++ + + W N D S Y+GTGAL
Sbjct: 390 TAIGLQMSHDQVAFLNL--NAGKVNVEQRVEEILRDLWQKNGDQCSTIYAGTGAL----- 442
Query: 466 RTGKRTYLGAIKDGINSISRYYQNNLTDGPREDAFDLFL 504
GK +KD S++R QNNL DG ++++FDLFL
Sbjct: 443 -DGK----SKLKDASRSLARTIQNNLMDGAKQESFDLFL 476
>SPAC3C7.01c [I] KOG1889 Putative phosphoinositide phosphatase
Length = 323
Score = 149 bits (377), Expect = 1e-35
Identities = 96/281 (34%), Positives = 140/281 (49%), Gaps = 19/281 (6%)
Query: 309 QKGHELPVKEAYEQVVTALNDPKLHYIYFDFHHE-CRNMQWHKVKLLLDHLQSMGLSNKD 367
QKG E P++ +E++ +P L Y+Y+D+H + RN+ L L +QS+ + K
Sbjct: 25 QKGREAPLRSGFEKLCKRNKNPPLSYVYYDYHKQGSRNLP-----LFLAEIQSLLIEGKY 79
Query: 368 FFHKTLDANGVTLQVFSKQQSVVRTNCMDCLDRTNVVQSVLAHWVLQEEFKTVGLTDDTG 427
+ + Q + VRTNCMDCLDRTNV+Q+ +A ++L + +G+ +
Sbjct: 80 YAEHGSKTTAM-------QTNFVRTNCMDCLDRTNVIQTSIAQFILNMQLHDIGVLSSSE 132
Query: 428 LWELDKNLLFEFQSFWADNADAVSVAYSGTGALKTDFTRTGKRTYLGAIKDGINSISRYY 487
E + L +F+ WA+ D +S Y+GT ALK D TR G RT GA KD +N RY
Sbjct: 133 SLEEYDSFLQDFRLIWANTGDYISDLYTGTPALKGDVTRHGTRTIFGAFKDLLNCFRRYI 192
Query: 488 QNNLTDGPREDAFDLFLGNFRPYASVVHSPFPDRRPMLIQAVPTMIYAALTVMMATILFP 547
NN DG +D++DL LG FRPY S+ P R P + + IL
Sbjct: 193 LNNFFDGMLQDSYDLGLGVFRPYDSLSIPDLPLRFHWTRFVAP-----GIFLFTTIILTI 247
Query: 548 KNHFTSAKNLSFFFGSFSIVVLCTHFVFKRGIQYVNWPKLV 588
+ F + S +V + F R QYVNWP+LV
Sbjct: 248 QELFGNPSLFCRLLYSIPMVNAGIYLYFHRR-QYVNWPRLV 287
>7291368 [U] KOG0566 Inositol-145-triphosphate 5-phosphatase (synaptojanin)
INP51/INP52/INP53 family
Length = 1218
Score = 146 bits (369), Expect = 8e-35
Identities = 131/507 (25%), Positives = 221/507 (42%), Gaps = 73/507 (14%)
Query: 59 IGIIKLKFGK----YVIIANRVEEAGCLNGHNVYKVAEHTIISVDKKQRPDSDESQYLQL 114
+G ++L G+ ++++ G + ++++ + T +S+ + S+ +L
Sbjct: 64 LGALQLNAGESTVLFLVLVTGCVSMGKIGDIEIFRITQTTFVSLQNAAPNEDKISEVRKL 123
Query: 115 LEQHL---------AGATLFYSYGYDLTNSAQRNEELESSAVSWEQADRRFFWNYYVTES 165
L A A+ SY +D+T AQR ++ + + D RFFWN +
Sbjct: 124 LNSGTFYFAHTNASASASGASSYRFDITLCAQRRQQTQ-------ETDNRFFWNRMMHIH 176
Query: 166 LQKLAKVDDRVSDFIIPMIYGYAKVVDTVFHATPISIGLITRRSIFRAGTRYFRRGIDEH 225
L + +D +++ + G +V A +I+R S RAGTR+ RG ++
Sbjct: 177 LMRFG-ID--CQSWLLQAMCGSVEVRTVYIGAKQARAAIISRLSCERAGTRFNVRGTNDE 233
Query: 226 GNVGNFNETEQVLCVQKPMKDGYHFFSFLQTRGSVPVYWAE---------XXXXXXXXXX 276
G V NF ETEQV+ V + S++QTRGSVP++W +
Sbjct: 234 GYVANFVETEQVIYVDGDVT------SYVQTRGSVPLFWEQPGVQVGSHKVKLSRGFETS 287
Query: 277 XXAENSSLDATKKHFDEQTRXXXXXXXXXXXXQKGHELPVKEAYEQVVTALNDPKLHYIY 336
A + + ++ + QT K E + +++ + ++
Sbjct: 288 AAAFDRHMSMMRQRYGYQT--VVNLLGSSLVGSKEGEAMLSNEFQRHHGMSAHKDVPHVV 345
Query: 337 FDFHHECRNMQWHKVKLLLDHLQSMGLSNKDFFHKTLDANGVTLQVFSKQQSVVRTNCMD 396
FD+H ECR + + L + + + G +N FH + NG QV +Q VVRTNC+D
Sbjct: 346 FDYHQECRGGNFSALAKLKERIVACG-ANYGVFHAS---NG---QVLREQFGVVRTNCLD 398
Query: 397 CLDRTNVVQSVLAHWVL---QEEFKTVGLTDDTGLWELDKNLLFEFQSFWADNADAVSVA 453
CLDRTN VQ+ L L E K G + +E F+ W +N + VS
Sbjct: 399 CLDRTNCVQTYLGLDTLGIQLEALKMGGKQQNISRFE------EIFRQMWINNGNEVSKI 452
Query: 454 YSGTGALKTDFTRTGKRTYLGAIKDGINSISRYYQNNLTDGPREDAFDLFLGNFRPYASV 513
Y+GTGA++ + DG S +R QNNL D +++A D+ L S
Sbjct: 453 YAGTGAIQGG----------SKLMDGARSAARTIQNNLLDNSKQEAIDVLL-----VGST 497
Query: 514 VHSPFPDRRPMLIQAVPTMIYAALTVM 540
+ S DR +L+ + M++A TV+
Sbjct: 498 LSSELADRARILLPS--NMLHAPTTVL 522
>Hs4507335 [U] KOG0566 Inositol-145-triphosphate 5-phosphatase (synaptojanin)
INP51/INP52/INP53 family
Length = 1575
Score = 144 bits (364), Expect = 3e-34
Identities = 132/486 (27%), Positives = 221/486 (45%), Gaps = 57/486 (11%)
Query: 38 VNVLGSTEFP-VRGNIMKVA---ALIGIIKLKFGK----YVIIANRVEEAGCLNGHNVYK 89
V VL S E ++G KV L+G+++L G Y+++ G + V++
Sbjct: 38 VAVLSSAEKEAIKGTYSKVLDAYGLLGVLRLNLGDTMLHYLVLVTGCMSVGKIQESEVFR 97
Query: 90 VAEHTIISVDKKQRPDSDESQYLQLLEQHLAGATLFYSYG-----YDLTNSAQRNEELES 144
V IS+ R DS + + + + L ++++ DL+ +A R+ + ++
Sbjct: 98 VTSTEFISL----RIDSSDEDRISEVRKVLNSGNFYFAWSASGISLDLSLNAHRSMQEQT 153
Query: 145 SAVSWEQADRRFFWNYYVTESLQKLAKVDDRVSDFIIPMIYGYAKVVDTVFHATPISIGL 204
+ D RFFWN + L+ D D+++ ++ G ++ L
Sbjct: 154 T-------DNRFFWNQSLHLHLKHYGVNCD---DWLLRLMCGGVEIRTIYAAHKQAKACL 203
Query: 205 ITRRSIFRAGTRYFRRGIDEHGNVGNFNETEQVLCVQKPMKDGYHFFSFLQTRGSVPVYW 264
I+R S RAGTR+ RG ++ G+V NF ETEQV+ + + SF+Q RGSVP++W
Sbjct: 204 ISRLSCERAGTRFNVRGTNDDGHVANFVETEQVVYLDDSVS------SFIQIRGSVPLFW 257
Query: 265 AEXXXXXXXXXXXXAEN--SSLDATKKHFDEQTRXXXXXXXXXXXXQKGHELPVKEAYEQ 322
+ + ++ A +HF K E + +A++
Sbjct: 258 EQPGLQVGSHRVRMSRGFEANAPAFDRHFRTLKNLYGRQIIVNLLGSKEGEHMLSKAFQS 317
Query: 323 VVTALNDPK-LHYIYFDFHHECRNMQWHKVKLLLDHLQSMGLSNKDFFHKTLDANGVTLQ 381
+ A + + FD+H + + K+ +L Q + FF+ NG +Q
Sbjct: 318 HLKASEHAADIQMVNFDYHQMVKGGKAEKLHSVLKP-QVQKFLDYGFFY----FNGSEVQ 372
Query: 382 VFSKQQSVVRTNCMDCLDRTNVVQSVLAHWVLQEEFKTVGLTDDTGLWELDKNLLFEFQS 441
Q VRTNC+DCLDRTN VQ+ L +L ++ + +GL + +L F+S
Sbjct: 373 --RCQSGTVRTNCLDCLDRTNSVQAFLGLEMLAKQLEALGLAEKP---QLVTRFQEVFRS 427
Query: 442 FWADNADAVSVAYSGTGALKTDFTRTGKRTYLGAIKDGINSISRYYQNNLTDGPREDAFD 501
W+ N D++S Y+GTGAL+ GK +KDG S++R QNN D +++A D
Sbjct: 428 MWSVNGDSISKIYAGTGALE------GK----AKLKDGARSVTRTIQNNFFDSSKQEAID 477
Query: 502 -LFLGN 506
L LGN
Sbjct: 478 VLLLGN 483
>7295697 [I] KOG1888 Putative phosphoinositide phosphatase
Length = 858
Score = 141 bits (355), Expect = 3e-33
Identities = 114/530 (21%), Positives = 222/530 (41%), Gaps = 68/530 (12%)
Query: 29 LNVSTHENEVNVLGSTEFPVR----GNIMKVAALIGIIKLKFGKYVIIANRVEEAGCLNG 84
L++ + NE N L F + ++G ++ G Y+++ + + +
Sbjct: 54 LSIEENANEFNSLEIRRFVASLSGSPKVTSAYGVLGFVRFLEGYYLLLVTKRKCCAHIGR 113
Query: 85 HNVYKVAEHTIISVDK---KQRPDSDESQYLQLLEQHLAGATLFYSYGYDLTNSAQRNE- 140
H VY + + ++ V++ ++ P E +Y ++ + + ++SY YDLT + Q NE
Sbjct: 114 HLVYTIKDTVMVRVNEVTSQRPPHPHEDRYKRMFQNIDLRSNFYFSYSYDLTRTLQYNES 173
Query: 141 -----------ELESSAVSW-----------EQAD--------RRFFWNYYVTESLQKLA 170
+ + W E+ D +RF WN Y+ + ++ +
Sbjct: 174 APRYVGAKVDLDRDEPLPDWNTLTSNVDKAHERVDYAFRSDSRKRFVWNAYLLQPMEGIM 233
Query: 171 KVDDRVSDFIIPMIYGYAKVVDTVFHATPISIGLITRRSIFRAGTRYFRRGIDEHGNVGN 230
+ D+++ + +G+ +++ L+ RRS AGTR+ +RG + G+V N
Sbjct: 234 -----LKDWLLEVTHGFVSQSCISIFGRHVNVCLVARRSSRFAGTRFLKRGANFQGDVAN 288
Query: 231 FNETEQVLCVQKPMKDGYHFFSFLQTRGSVPVYWAEXXXXXXXXXXXXAE--NSSLDATK 288
ETEQ++ DG +F Q RGS+P +W++ + +
Sbjct: 289 EVETEQIV------SDGQRICAFTQMRGSIPSHWSQDISKMVPKPQIQLDICDPYAQTPS 342
Query: 289 KHFDEQTRXXXXXXXXXXXXQKG----HELPVKEAYEQVVTALND-----PKLHYIYFDF 339
HF+ +K HE + + E + LN ++ +I+FD
Sbjct: 343 LHFERLLFHYGAPLIMLNLVKKRERRKHESIISKELEYSIRYLNQFLPPPHRMKHIHFDM 402
Query: 340 HHECRNMQWHKVKLLLDHLQSMGLSNKDFFHKTLDANGVTLQVFSKQQSVVRTNCMDCLD 399
+ R + ++ L H +S+ FF G+ Q +VRTNC+DCLD
Sbjct: 403 ARQSRLSGGNVMEQLAIHAESIVQMTGMFFKAAGSEPGL-------QTGIVRTNCVDCLD 455
Query: 400 RTNVVQSVLAHWVLQEEFKTVGLTDDTGLWELDKNLLFEFQSFWADNADAVSVAYSGTGA 459
RTN Q + L + + +G L E D + + ++ + ++ D +++ Y G+
Sbjct: 456 RTNSAQFAIGKCALGHQLERLGFVKSAKL-EFDSDCVTMLENLYEEHGDTLALQYGGSQL 514
Query: 460 LKTDFTRTGKRTYLGAIKDGINSISRYYQNNLTDGPREDAFDLFLGNFRP 509
+ T + D + ++SRYY N +D ++ + +LFLG ++P
Sbjct: 515 VHRIKTYRKTAPWGSQGSDVMQTLSRYYSNTFSDTEKQHSINLFLGIYKP 564
>At3g43220 [I] KOG1888 Putative phosphoinositide phosphatase
Length = 794
Score = 139 bits (350), Expect = 1e-32
Identities = 118/513 (23%), Positives = 210/513 (40%), Gaps = 81/513 (15%)
Query: 58 LIGIIKLKFGKYVIIANRVEEAGCLNGHNVYKVAEHTIISVDKKQRPDSDESQYLQLLEQ 117
+IG +K Y+++ G L GH+VY V++ I+++ ++
Sbjct: 91 IIGFVKFLGPYYMLLITERRHIGDLFGHSVYAVSKSEIVALHNST------------VQC 138
Query: 118 HLAGATLFYSYGYDLTNSAQRNEELESSAVSWEQADRRFFWNYYVTESLQKLAKVDDRVS 177
+ A + SY Y++ S Q+N + + ++ F WN ++T ++ R +
Sbjct: 139 NFANSRDENSYSYNVMRSYQKN--VCNYETGHNLYEKMFVWNEFLTRGIRHHL----RNT 192
Query: 178 DFIIPMIYGYAKVVDTVFHATPISIGLITRRSIFRAGTRYFRRGIDEHGNVGNFNETEQV 237
+ + ++YG+ K I LI RRS AGTRY +RG++ +G+V N ETEQ+
Sbjct: 193 LWTVALVYGFFKQASLSESGKDFKITLIARRSRHNAGTRYLKRGVNRNGDVANDVETEQI 252
Query: 238 LCVQKPMKDGYHFFSFLQTRGSVPVYWAEXXXXXXX--XXXXXAENSSLDATKKHFDEQT 295
+ P S +Q RGS+P++W++ + + +AT+ HFD
Sbjct: 253 VSEDVPEDHPMQISSVVQNRGSIPLFWSQETSRLNLKPDIVLSKKEPNYEATRLHFDNLV 312
Query: 296 RX----XXXXXXXXXXXQKGHELPVKEAYEQVVTALN-----DPKLHYIYFDFHHECRNM 346
++ E ++E + + +N + +L ++++D H R+
Sbjct: 313 ERYGNPIIILNLIKTKERRPRESILREEFVNAIDFINKDLPEENRLRFLHWDLHKHFRS- 371
Query: 347 QWHKVKLLLDHLQSMGLSNKDFFHKTL------------------------------DAN 376
+ V LL + + L D F+ + D N
Sbjct: 372 KTKNVLALLCKVATCALMLTDLFYYQVTPAMTIEDSMSLSSSSDADTGDISPHTSSDDDN 431
Query: 377 GVTLQVFSK-------------------QQSVVRTNCMDCLDRTNVVQSVLAHWVLQEEF 417
G + K Q V+RTNC+DCLDRTNV Q L ++
Sbjct: 432 GDHDSLEKKSSRSKNIAYGKCDVKPPRLQSGVLRTNCIDCLDRTNVAQYAYGWAALGQQL 491
Query: 418 KTVGLTDDTGLWELDKNLLFEFQSFWADNADAVSVAYSGTGALKTDFT-RTGKRTYLGAI 476
+G+ D + ELD L + D ++ Y G+ A F+ R G+
Sbjct: 492 HVLGIRDVPAI-ELDDPLAISLMGLYERMGDTLAHQYGGSAAHNKVFSERRGQWRAATQS 550
Query: 477 KDGINSISRYYQNNLTDGPREDAFDLFLGNFRP 509
++ + ++ RYY N D ++DA ++FLG F+P
Sbjct: 551 QEFLRTLQRYYNNAYMDADKQDAINIFLGTFQP 583
>Hs14747866 [U] KOG0566 Inositol-145-triphosphate 5-phosphatase (synaptojanin)
INP51/INP52/INP53 family
Length = 1496
Score = 135 bits (340), Expect = 2e-31
Identities = 128/533 (24%), Positives = 234/533 (43%), Gaps = 64/533 (12%)
Query: 50 GNIMKVAALIGIIKLKFG----KYVIIANRVEEAGCLNGHNVYKVAEHTIISVDKKQRPD 105
G + +G ++LK G ++++ G + +YK+ + ++ +
Sbjct: 55 GKLTDAYGCLGELRLKSGGTSLSFLVLVTGCTSVGRIPDAEIYKITATDFYPLQEEAK-- 112
Query: 106 SDESQYLQLLEQHLAGATLFYSYG-----YDLTNSAQRNEELESSAVSWEQADRRFFWNY 160
E + L L++ L+ ++S+ +DLT Q+ + S W + FFWN
Sbjct: 113 --EEERLIALKKILSSGVFYFSWPNDGSRFDLTVRTQKQGDDSSE---WGNS---FFWNQ 164
Query: 161 YVTESLQKLAKVDDRVS--DFIIPMIYGYAKVVDTVFHATPISIGLITRRSIFRAGTRYF 218
+ L++ +VS D+++ +I G + L++R S R GTR+
Sbjct: 165 LLHVPLRQ-----HQVSCCDWLLKIICGVVTIRTVYASHKQAKACLVSRVSCERTGTRFH 219
Query: 219 RRGIDEHGNVGNFNETEQVLCVQKPMKDGYHFFSFLQTRGSVPVYWAEXXXXXXXXXXXX 278
RG+++ G+V NF ETEQ++ M DG SF+Q RGSVP++W +
Sbjct: 220 TRGVNDDGHVSNFVETEQMIY----MDDGVS--SFVQIRGSVPLFWEQPGLQVGSHHLRL 273
Query: 279 AENSSLDATKKHFDEQT----RXXXXXXXXXXXXQKGHELPVKEAYEQVVTA-LNDPKLH 333
+ L+A FD +G E + A+++++ A +
Sbjct: 274 --HRGLEANAPAFDRHMVLLKEQYGQQVVVNLLGSRGGEEVLNRAFKKLLWASCHAGDTP 331
Query: 334 YIYFDFHHECRNMQWHKVKLLLDHLQSMGLSNKDFFHKTLDANGVTLQVFSKQQSVVRTN 393
I FDFH + + K++ LL + + D F K + + Q+ +R N
Sbjct: 332 MINFDFHQFAKGGKLEKLETLLRPQLKLHWEDFDVFTKGENVSP------RFQKGTLRMN 385
Query: 394 CMDCLDRTNVVQSVLAHWVLQEEFKTVGLTDDTGLWELDKNLLFEFQSFWADNADAVSVA 453
C+DCLDRTN VQS +A VL + KT+GL+ + + F++ W+ N ++S
Sbjct: 386 CLDCLDRTNTVQSFIALEVLHLQLKTLGLSSK----PIVDRFVESFKAMWSLNGHSLSKV 441
Query: 454 YSGTGALKTDFTRTGKRTYLGAIKDGINSISRYYQNNLTDGPREDAFDLFLGNFRPYASV 513
++G+ AL+ + +G +KDG S+SR Q+N DG +++A L L V
Sbjct: 442 FTGSRALE-------GKAKVGKLKDGARSMSRTIQSNFFDGVKQEAIKLLL-----VGDV 489
Query: 514 VHSPFPDRRPMLIQAVPTMIYAALTVMMATILFPKNHFTSAKNLSFFFGSFSI 566
D+ ML+ + ++ + M ++ FT+ K + G++++
Sbjct: 490 YGEEVADKGGMLLDSTALLVTPRILKAMTE---RQSEFTNFKRIRIAMGTWNV 539
>At1g17340 [I] KOG1888 Putative phosphoinositide phosphatase
Length = 802
Score = 135 bits (339), Expect = 2e-31
Identities = 114/493 (23%), Positives = 213/493 (43%), Gaps = 51/493 (10%)
Query: 58 LIGIIKLKFGKYVIIANRVEEAGCLNGHNVYKVAEHTII-----SVDKKQRPDSDESQYL 112
+IG ++ Y+++ + ++ G + GH VY +AE +I S+ K E +Y
Sbjct: 106 IIGFVRFLEPYYMLLITKRKKVGEICGHTVYGIAESQMIAIPHPSIQSKVAKSEAELRYK 165
Query: 113 QLLEQHLAGATLFYSYGYDLTNSAQRNEELESSAVSWEQADRRFFWNYYVTESLQKLAKV 172
+LL ++SY Y L S Q+N + ++ + F WN ++T ++K+ +
Sbjct: 166 KLLSVVDLSKNFYFSYTYHLMYSLQKN--IGNTERGNPHDNTMFVWNSFLTREIRKILQN 223
Query: 173 DDRVSDFIIPMIYGYAKVVDTVFHATPISIGLITRRSIFRAGTRYFRRGIDEHGNVGNFN 232
S + + +IYG+ + +I RRS AGTR RG+++ G V N
Sbjct: 224 ----SIWTVALIYGFFQQTKCSVSGEKFVFTIIARRSRHYAGTR---RGVNDIGRVANDV 276
Query: 233 ETEQVLCVQKPMKDGYHFFSFLQTRGSVPVYWAEXXXXX--XXXXXXXAENSSLDATKKH 290
ETEQ++ P S +Q RGS+P++W++ ++++ +AT+ H
Sbjct: 277 ETEQIVSKVVPAGQKIPITSVVQVRGSIPLFWSQEASVFNPQPEIILNKKDANYEATQHH 336
Query: 291 FDE-----QTRXXXXXXXXXXXXQKGH-ELPVKEAYEQVVTALN-----DPKLHYIYFDF 339
F R +K H E ++ + + + +N + +L I+FD
Sbjct: 337 FQNLRQRYGNRIIILNLLKTVTGEKKHRETILRGEFAKTIRFINKGMDREHRLKAIHFDL 396
Query: 340 HHECRNM-----QWHKVKL-----------------LLDHLQSMGLSNKDFFHKTLDANG 377
+ W ++L + D + + ++D + +
Sbjct: 397 SKHYKKYCIYAPYWKSLELTDLFYCKAPSGVGAEEVIYDSFFNNPIPSQDEEASSPEKED 456
Query: 378 VTLQVFSKQQSVVRTNCMDCLDRTNVVQSVLAHWVLQEEFKTVGLTDDTGLWELDKNLLF 437
+ +F Q V+RTNC+DCLDRTN Q L + +T+G++ + +L+ L
Sbjct: 457 MKADIFLLQNGVLRTNCIDCLDRTNFAQYAHGLVSLGHQLRTLGISGPP-VVDLNNPLAI 515
Query: 438 EFQSFWADNADAVSVAYSGTGALKTDF-TRTGKRTYLGAIKDGINSISRYYQNNLTDGPR 496
E + + +++ Y G+ A F G + +D ++ RYY N D +
Sbjct: 516 ELMDAYQKMGNTLAMQYGGSEAHSKMFCDLRGNWNMVMRQRDIFTAVRRYYSNAYQDSDK 575
Query: 497 EDAFDLFLGNFRP 509
++A ++FLG+FRP
Sbjct: 576 QNAINVFLGHFRP 588
>ECU03g1160 [I] KOG1889 Putative phosphoinositide phosphatase
Length = 518
Score = 126 bits (317), Expect = 9e-29
Identities = 115/444 (25%), Positives = 191/444 (42%), Gaps = 52/444 (11%)
Query: 60 GIIKLKFGKYVIIANRVEEAGCLNGHNVYKVAEHTIISVDKKQRPDSDESQYLQLLEQHL 119
G+I + Y+I+ G + H VY++ + II + +++ + ++ +++ L
Sbjct: 48 GMITISKSSYLILVVDAVIRGMMYEHAVYEIRDVEIIQLTREKAKNFTNE--MKNVKKFL 105
Query: 120 AGATLFYS-YGYDLTNSAQRNEELESSAVSWEQADRRFFWNYYVTESLQKLAKVDDRVSD 178
+++S Y T S +++E D+ F +N E L D+ S
Sbjct: 106 EKTGIYFSTYPLYKTMSIKKDE------------DKDFLFNSLPLEKF--LGHAGDKGSL 151
Query: 179 FIIPMIYGYAKVVDTVFHATPISIGLITRRSIFRAGTRYFRRGIDEHGNVGNFNETEQVL 238
F + I G+ VD + + LI+RRS RAG RYF RG D G V N+ ETEQ++
Sbjct: 152 FSVWCIQGFFGSVDI----GTVCLRLISRRSWRRAGARYFSRGSDASGYVSNYVETEQII 207
Query: 239 CVQKPMKDGYHFFSFLQTRGSVPVYWAEXXXXXXXXXXXXAENSSLDATKKHFDEQTRXX 298
DG S LQ RGS+P+ W ++ L K ++
Sbjct: 208 Y------DGEKTVSHLQVRGSIPLIWEHVLGREYNPKIVVSDRKILHIADKVLRDK---Y 258
Query: 299 XXXXXXXXXXQKGHELPVKEAYEQVVTALNDPKLHYIYFDFHHECRNMQWHKVKLLLDHL 358
G+E + AYE+ + N +H F+F E ++ K L
Sbjct: 259 GDVFYLNLIRNSGYEGMLHCAYEKELLGNNKEGVH---FNFFKEGGILEGDTRKKFL--- 312
Query: 359 QSMGLSNKDFFHKTLDANGVTLQVFSKQQSVVRTNCMDCLDRTNVVQSVLAHWVLQEEFK 418
GL + G S Q V+RTNC+DCLDRTN+ Q ++ +L+++
Sbjct: 313 ---GLVEQALLSFGYHGPG------SLQSGVIRTNCIDCLDRTNISQFIMGEIILEKQLS 363
Query: 419 TVGLTDDTGLWELDKNLLFEFQSFWADNADAVSVAYSGTGALKTDFTRTGKRTYLGAIKD 478
+ D E K L W DN +++S+ YSG+ ALK+ F ++ + ++D
Sbjct: 364 HFDIEDKKHFCEQAKCL-------WYDNGNSLSMQYSGSFALKSHFLSRKRQGVVDRLRD 416
Query: 479 GINSISRYYQNNLTDGPREDAFDL 502
GI RY+ N L G + +++
Sbjct: 417 GIIGFQRYFINRLCHGSLQTTYEI 440
>ECU08g1420 [U] KOG0566 Inositol-145-triphosphate 5-phosphatase (synaptojanin)
INP51/INP52/INP53 family
Length = 453
Score = 112 bits (280), Expect = 2e-24
Identities = 106/460 (23%), Positives = 187/460 (40%), Gaps = 76/460 (16%)
Query: 58 LIGIIKLK----FGKYVIIANRVEEAGCLNGHNVYKVAEHTIISVDKKQRPDSDESQYLQ 113
++GI++++ + +++ + AG G +YK+ + +++++ +PD SQ
Sbjct: 44 ILGILRVEKNDAYEEFLAFVTKSTLAGMYEGIEIYKIDKIKFLNINEPDKPDEVMSQVRG 103
Query: 114 LLEQHLAGATLFYSYGYDLTNSAQRNEELESSAVSWEQADRRFFWNYY-------VTESL 166
++ H FY + L +E + W + R Y+ V
Sbjct: 104 FVQSHD-----FYYFSTPLF--------IEDEFI-WNRHMRANLLKYFGPTSYPWVLSHR 149
Query: 167 QKLAKVDDRVSDFIIPMIYGYA-KVVDTVFHATPISIGLITRRSIFRAGTRYFRRGIDEH 225
K + +S A K + +H + L++ S R GTRY RGIDE
Sbjct: 150 PKSPSLSLNISTLFCGFFVAKAFKTSEDFYH-----MKLLSLVSSNRVGTRYLCRGIDEE 204
Query: 226 GNVGNFNETEQVLCVQKPMKDGYHFFSFLQTRGSVPVYWAEXXXXXXXXXXXXAENSSLD 285
GN F +T + ++ F F RGSVP++W++ E+ ++
Sbjct: 205 GNASLFVKTHF-----QTKRNNSTIFDFTIIRGSVPIFWSQRGHGIPAKVNIYGEDGAVK 259
Query: 286 -ATKKHFDEQTRXXXXXXXXXXXXQKGHELPVKEAYEQVVTALNDPKLHYIYFDFHHECR 344
A KHF + R +K +E + + +++ N P Y FD +
Sbjct: 260 KAFAKHFKKLRREYGKIYVINLLGEKKYEKQLTSHFSRLLDLENIP---YTTFDLNAHAS 316
Query: 345 NMQWHKVKLLLDHLQSMGLSNKDFFHKTLDANGVTLQVFSKQQSVVRTNCMDCLDRTNVV 404
N + +K LL +F LQ +Q V R NC+DCLDRTNV
Sbjct: 317 N--YDDLKFLL------------YFK---------LQGIGQQDIVFRVNCLDCLDRTNVA 353
Query: 405 QSVLAHWVLQEEFKTVGLTDDTGLWELDKNLLFEFQSFWADNADAVSVAYSGTGALKTDF 464
QS++ + ++ D N L Q WADN +++S Y+G+ A+K +
Sbjct: 354 QSLICMFYFEKVV-------------CDGNALKRMQECWADNGNSLSNLYTGSDAMKREL 400
Query: 465 TRTGKRTYLGAIKDGINSISRYYQNNLTDGPREDAFDLFL 504
G+R+++G + D + S +R TD + ++ L
Sbjct: 401 ALKGRRSFVGYMDDFVISATRLINGRFTDRQKHSIINVLL 440
>At1g22620 [I] KOG1888 Putative phosphoinositide phosphatase
Length = 925
Score = 106 bits (264), Expect = 1e-22
Identities = 75/313 (23%), Positives = 141/313 (44%), Gaps = 30/313 (9%)
Query: 52 IMKVAALIGIIKLKFGKYVIIANRVEEAGCLNGHNVYKVAEHTIISV-----DKKQRPDS 106
+ KV + G K Y+++ + + GC+ GH +Y + E +ISV
Sbjct: 105 VAKVYGIAGCAKFMESYYLVLVTKRRQIGCICGHAIYAIDESQMISVPHATIQSDVANSK 164
Query: 107 DESQYLQLLEQHLAGATLFYSYGYDLTNSAQRNEELESSAVSWEQADRRFFWNYYVTESL 166
E +Y +LL FYSY Y + S Q+N + SS D F WN Y+T+ +
Sbjct: 165 TELRYKKLLSSVDLTKDFFYSYTYPIMQSLQKN--VLSSGEEGMPYDNIFVWNSYLTQPI 222
Query: 167 QKLAKVDDRVSDFIIPMIYGYAKVVDTVFHATPISIGLITRRSIFRAGTRYFRRGIDEHG 226
+ ++ ++ + + + +++G+ K + + S+ L++RRS AGTRY +RG+++ G
Sbjct: 223 R--SRCNNTI--WTLALVHGHFKQIRLSIYGRDFSVTLVSRRSRHFAGTRYLKRGVNDRG 278
Query: 227 NVGNFNETEQVLCVQKPMKDGYHFFSFLQTRGSVPVYWAEXXXXXXXXXXXXAE--NSSL 284
V N ETEQ++ + S +Q RGS+P++W++ + + +
Sbjct: 279 RVANDVETEQLVLDDEAGSCKGKMSSVVQMRGSIPLFWSQEASRFSPKPDIFLQRYDPTY 338
Query: 285 DATKKHFDEQTR------------XXXXXXXXXXXXQKGHELPVKEAYEQVVTALN---- 328
++TK HF++ ++ E+ ++ + V LN
Sbjct: 339 ESTKMHFEDLVNRYGNPIIVLNLIKTNIHGNIQTVEKRPREMVLRREFANAVGYLNSIFR 398
Query: 329 -DPKLHYIYFDFH 340
+ L +I++DFH
Sbjct: 399 EENHLKFIHWDFH 411
Score = 84.3 bits (207), Expect = 5e-16
Identities = 47/125 (37%), Positives = 67/125 (53%), Gaps = 2/125 (1%)
Query: 386 QQSVVRTNCMDCLDRTNVVQSVLAHWVLQEEFKTVGLTDDTGLWELDKNLLFEFQSFWAD 445
Q V+RTNC+DCLDRTNV Q L + +GL+D + + D ++ +
Sbjct: 519 QSGVLRTNCIDCLDRTNVAQYAYGLAALGRQLHAMGLSDTPKI-DPDSSIAAALMDMYQS 577
Query: 446 NADAVSVAYSGTGALKTDFT-RTGKRTYLGAIKDGINSISRYYQNNLTDGPREDAFDLFL 504
DA++ Y G+ A T F R GK ++ + SI RYY N TDG ++DA +LFL
Sbjct: 578 MGDALAQQYGGSAAHNTVFPERQGKWKATTQSREFLKSIKRYYSNTYTDGEKQDAINLFL 637
Query: 505 GNFRP 509
G F+P
Sbjct: 638 GYFQP 642
>At5g20840 [I] KOG1888 Putative phosphoinositide phosphatase
Length = 774
Score = 103 bits (258), Expect = 6e-22
Identities = 113/510 (22%), Positives = 193/510 (37%), Gaps = 119/510 (23%)
Query: 58 LIGIIKLKFGKYVIIANRVEEAGCLNGHNVYKVAEHTIISVDKKQRPDS-----DESQYL 112
+IG IK Y+++ E G + GH VY+V++ +I++ + DE+ +
Sbjct: 100 IIGFIKFLGPYYMLLITERREIGEICGHIVYEVSKSDMIALQHSSVLCNTANLRDENSFQ 159
Query: 113 QLLEQHLAGATLFYSYGYDLTNSAQRNEELESSAVSWEQADRRFFWNYYVTESLQKLAKV 172
+ + H +G TL+ + F WN ++T +
Sbjct: 160 KNICDHESGGTLY---------------------------KKMFVWNEFLTRGTRHHL-- 190
Query: 173 DDRVSDFIIPMIYGYAKVVDTVFHATPISIGLITRRSIFRAGTRYFRRGIDEHGNVGNFN 232
R + + + ++YG+ K + LI RRS AGTRY +RGI+E GNV N
Sbjct: 191 --RNTLWTVALVYGFFKQTILSEAGRNFKLTLIARRSRHNAGTRYLKRGINESGNVANDV 248
Query: 233 ETEQVLCVQKPMKDGYHFFSFLQTRGSVPVYWAEXXXXXXXXXXXXAENSSLDATKKHFD 292
ETEQ++ P+ S +Q RGS+P++W++ AT+ HF+
Sbjct: 249 ETEQIVSEDVPVDRPMQISSVVQNRGSIPLFWSQETSRMKVKPDI--------ATRVHFE 300
Query: 293 EQTRX----XXXXXXXXXXXQKGHELPVKEAYEQVVTALN-----DPKLHYIYFDFHHEC 343
+K E ++ + + +N + +L ++++D H
Sbjct: 301 NLVERYGVPIIILNLIKTNERKPRESILRAEFANAIDFINKDLPEENRLRFLHWDLHKHF 360
Query: 344 RNMQWHKVKLL-----------------------LDHLQSMGLSNKDFF-HKTLD----- 374
+ + + LL L+ S+ S+ D H + D
Sbjct: 361 HSKTENVLALLGKVAACALMLTGFFYYQLTPAMKLEGYMSLSSSDADTSPHNSSDDDSRD 420
Query: 375 --------------ANG-VTLQVFSKQQSVVRTNCMDCLDRTNVVQSVLAHWVLQEEFKT 419
ANG ++ Q V+RTNC+DCLDRTNV Q L ++
Sbjct: 421 YDSLEKNCRPSKNVANGDYDVKPSRLQSGVLRTNCIDCLDRTNVAQYAYGWAALGQQLHA 480
Query: 420 VGLTDDTGLWELDKNLLFEFQSFWADNADAVSVAYSGTGALKTDFTRTGKRTYLGAIKDG 479
+G+ D + ELD L + D ++ Y G+ A +
Sbjct: 481 LGIRDAPTI-ELDDPLSSTLMGLYERMGDTLAYQYGGSAAHNK-----------ARPVES 528
Query: 480 INSISRYYQNNLTDGPREDAFDLFLGNFRP 509
N ++R +++ T FLG FRP
Sbjct: 529 SNPVTRVLEDSAT----------FLGTFRP 548
>SPBC577.13 [U] KOG0566 Inositol-145-triphosphate 5-phosphatase (synaptojanin)
INP51/INP52/INP53 family
Length = 889
Score = 98.2 bits (243), Expect = 3e-20
Identities = 93/388 (23%), Positives = 166/388 (41%), Gaps = 42/388 (10%)
Query: 156 FFWNYYVTESLQKLAKVDDRVSDFIIPMIYGYAKVVDTVFHATPISIGLITRRSIFRAGT 215
+ WN ++ L + F +++ + V+ +F +S+ +I++ S + +
Sbjct: 204 YCWNRFLITELDNHFSEAHILEKFPNLLLHCFRGYVERMF-IDSMSMSIISKVSSYGSRQ 262
Query: 216 RYFRRGIDEHGNVGNFNETEQVLCVQKPMKDGYHFFSFLQTRGSVPVYWAEXXXXXXXXX 275
Y GID+ F ETE ++ + + + FSF+Q RG+VP +W E
Sbjct: 263 TYPPSGIDDSSYCSMFVETEFIVEIAQTV------FSFVQVRGTVPCFWEEQFSSWYGPS 316
Query: 276 XXXAENSSLDAT--KKHFDEQTRXXXXXXXXXXXXQKGHELPVKEAYEQVVTALNDPKL- 332
+S + HF + + KG E + EAY+ + L P +
Sbjct: 317 ISFLRSSQASQSLFNFHFSKLYKAYGDIYVIDLLQTKGFEASLYEAYKHHLMLLPFPAVV 376
Query: 333 HYIYFDFHHECRNMQWHKVKLLLDHLQSMGLSNKDFFHKTLDANGVTLQVFSKQQSVVRT 392
+F ++ L D L+ MG + K + L+ S Q+ V R
Sbjct: 377 KKFHFTPDPARPDIDPRLETDLADDLKEMGYTQKSIENDMLE---------SFQKGVFRI 427
Query: 393 NCMDCLDRTNVVQSVLAHWVLQEEFKT--VGLTDDTGLWELDKNLLFEFQSFWADNADAV 450
N +DCL RTNV+Q ++ VL++ F +G+T N+L + W++N DA+
Sbjct: 428 NDLDCLGRTNVIQYQISRLVLKDIFFNLQIGVTF---------NILEYLRHLWSNNGDAI 478
Query: 451 SVAYSGTGALKTDFTRTGKRTYLGAIKDGINSISRYYQNNLTDGPREDAFDLFLGNFRPY 510
+ +G G++ + TR G+++ G++ D S R Y D ++A L LG
Sbjct: 479 AKLITGVGSIGSSATRRGRKSIAGSLSDISKSFGRMYVGRYPDVESQNAILLLLG----- 533
Query: 511 ASVVHSPFPDRRPMLI-QAVPTMIYAAL 537
FP++ P+LI ++V + I L
Sbjct: 534 ------CFPNQSPVLISESVSSYIQGVL 555
>YIL002c [U] KOG0566 Inositol-145-triphosphate 5-phosphatase (synaptojanin)
INP51/INP52/INP53 family
Length = 946
Score = 73.6 bits (179), Expect = 9e-13
Identities = 95/483 (19%), Positives = 186/483 (37%), Gaps = 62/483 (12%)
Query: 55 VAALIGIIKLKFGKYVIIANRVEEAGCLNGHNVYKVAEHTIISVDKKQRP----DSDESQ 110
VA + G+ + F ++ +I ++V + ++YKV + S++ + E
Sbjct: 84 VAVISGVQNVGFPRWKLIDHQVRPS-----ESIYKVLDVDFYSLENDVFDYLLCERSEQN 138
Query: 111 YLQLLEQHLAG--------ATLFYSYGYDLTNSAQRNEELESSAVSWEQADRRFFWNYYV 162
Y +L+ +H G T +YS +D++N + + + + + D F WN +
Sbjct: 139 YDKLIHEHPCGPLKKLFSDGTFYYSRDFDISNIVKNHGLSHNLEYTVDNQDLSFIWNANL 198
Query: 163 TESL----QKLAKVDDRV---SDFIIPMIYGYAKVVDTVFHATPISIGLITRRSIFRAGT 215
+ K++ + ++ + F+ +I GY K SI +I+R S
Sbjct: 199 ASEVINWRSKISNEEKQLFANAGFLTFVIRGYCKTALIEDGPNTASITIISRISTESKQD 258
Query: 216 RYFRRGIDEHGNVGNFNETEQVLCVQKPMKDGYHFFSFLQTRGSVPVYWAEXXXXXXXXX 275
GI E G V F ETE V+ +K FS+ Q GS+P++W
Sbjct: 259 TLELEGISEDGRVSLFVETEIVVTTEK------FIFSYTQVNGSIPLFWESVESQLLYGK 312
Query: 276 XXXAENSSLDAT---KKHFDEQTRXXXXXXXXXXXXQKGHELPVKEAYEQVVTALND--- 329
S++A +HFD T P E+ E++ D
Sbjct: 313 KIKVTKDSIEAQGAFDRHFDNLTSKYGVVSIVNIIK------PKSESQEKLALTYKDCAE 366
Query: 330 -PKLHYIYFDFHHECRNMQWHKVKLLLDHLQSMGLSNKDFFHKTLDANGVTLQV-FSKQQ 387
+ ++ HK+ LL +D + A ++ + F+KQ
Sbjct: 367 SKGIKITNIEYSSSVLTKSPHKLLYLL---------KQDIYEFGAFAYDISRGIYFAKQT 417
Query: 388 SVVRTNCMDCLDRTNVVQSVLAHWVLQEEFKTVGLTDDTGLWELDKNLLFEFQSFWADNA 447
V+R + D +++ N V+ +++ VL+ T++ ++EL L W++N
Sbjct: 418 GVLRISAFDSIEKPNTVERLVSKEVLEL------TTNEIDVFELTSPFLDAHDKLWSENY 471
Query: 448 DAVSVAYSGTGALKTDFTRTGKRTYLGAIK--DGIN-SISRYYQNNLTDGPREDAFDLFL 504
+ Y+ +T+ + + ++ D ++ IS+Y + + E +F
Sbjct: 472 YWLDRTYTKHTKNSGKYTKVYSKLFGSRVRLYDPLHIYISQYLKQLRSKYTFEKDISIFA 531
Query: 505 GNF 507
G F
Sbjct: 532 GTF 534
>At3g59770 [I] KOG1888 Putative phosphoinositide phosphatase
Length = 1616
Score = 63.5 bits (153), Expect = 9e-10
Identities = 86/421 (20%), Positives = 162/421 (38%), Gaps = 61/421 (14%)
Query: 57 ALIGIIKLKFGKYVIIANRVEEA--GCLNGHNVYKVAEHTIISVD--KKQRPDSDESQYL 112
A++G L +++A R+ + G VY VAE + + Q E++ +
Sbjct: 85 AILGYAVLGSFGMLLVATRLNPSIPDLPGGGCVYTVAESQWVKIPLYNPQPQGKGETKNI 144
Query: 113 QLLEQHLAGATLFYSYGYDLTNSAQRNEELESSAVSWEQADRRFFWNYYVTESLQKLAKV 172
Q L + ++ D+T L+S D F WN +++ + +
Sbjct: 145 QELTELDIDGKHYFCDTRDITRPFPSRMPLQSP-------DDEFVWNRWLSVPFKNIG-- 195
Query: 173 DDRVSDFIIPMIYGYAKVVDTVFHATPISI-GLITRRSIFRAGTRYFRRGIDEHGNVGNF 231
+ + + ++ G+A+ I L+ RRS GTRY RGI+ GN
Sbjct: 196 ---LPEHCVILLQGFAEYRPFGSSGQLEGIVALMARRSRLHPGTRYLARGINSCSGTGNE 252
Query: 232 NETEQVLCVQKPMKDGYHFFSFLQTRGSVPVYW-AEXXXXXXXXXXXXAENSSLDATKKH 290
E EQ++ + K F S++ RG++P++W AE A+ + ++
Sbjct: 253 VECEQLVWIPKRNGQSIAFNSYIWRRGTIPIWWGAELKMTAAEAEIYVADRDPYKGSTEY 312
Query: 291 F-----------------DEQTRXXXXXXXXXXXXQKGH---ELPVKEAYEQVVTALND- 329
+ + Q + + G E + + +E+ + +
Sbjct: 313 YQRLSKRYDTRNLDAPVGENQKKKAFVPIVCVNLLRSGEGKSECILVQHFEESMNFIKSS 372
Query: 330 -----PKLHYIYFDFHHECR-NMQWHKVKLLLDHLQS----MGLSNKDFF---HKTLDAN 376
++H I +D+H + + ++ L +L+S +G+S D+ + D
Sbjct: 373 GKLPYTRVHLINYDWHASVKLKGEQQTIEGLWMYLKSPTMAIGISEGDYLPSRQRLKDCR 432
Query: 377 GVTLQV---------FSKQQSVVRTNCMDCLDRTNVVQSVLAHWVLQEEFKTVGLTDDTG 427
G + + S Q V+R NC D LDRTN V E+ + +G++ DT
Sbjct: 433 GEVICIDDIEGAFCLRSHQNGVIRFNCADSLDRTNAASFFGGLQVFVEQCRRLGISLDTD 492
Query: 428 L 428
L
Sbjct: 493 L 493
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.321 0.137 0.409
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 36,182,355
Number of Sequences: 60738
Number of extensions: 1490864
Number of successful extensions: 3180
Number of sequences better than 1.0e-05: 33
Number of HSP's better than 0.0 without gapping: 17
Number of HSP's successfully gapped in prelim test: 16
Number of HSP's that attempted gapping in prelim test: 3005
Number of HSP's gapped (non-prelim): 50
length of query: 625
length of database: 30,389,216
effective HSP length: 112
effective length of query: 513
effective length of database: 23,586,560
effective search space: 12099905280
effective search space used: 12099905280
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)