ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIII0226 check: MH T KOG0201 Signal transduction mechanisms Serine/threonine protein kinase
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIII0226 73295 74743 483
(483 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YDR523c [T] KOG0201 Serine/threonine protein kinase 256 4e-68
Hs20070158 [T] KOG0201 Serine/threonine protein kinase 212 9e-55
7300224 [T] KOG0201 Serine/threonine protein kinase 209 1e-53
At3g15220 [T] KOG0201 Serine/threonine protein kinase 208 1e-53
At1g53165 [T] KOG0201 Serine/threonine protein kinase 208 2e-53
HsM5454174 [T] KOG0201 Serine/threonine protein kinase 204 3e-52
Hs21361358 [T] KOG0201 Serine/threonine protein kinase 204 3e-52
Hs15011880 [T] KOG0201 Serine/threonine protein kinase 201 2e-51
CE28674 [T] KOG0201 Serine/threonine protein kinase 199 1e-50
CE07510 [T] KOG0201 Serine/threonine protein kinase 199 1e-50
SPAC2C4.14c [T] KOG0201 Serine/threonine protein kinase 196 7e-50
Hs5454094 [T] KOG0574 STE20-like serine/threonine kinase MST 182 1e-45
Hs16178962 [T] KOG0574 STE20-like serine/threonine kinase MST 182 1e-45
Hs5454096 [T] KOG0574 STE20-like serine/threonine kinase MST 180 5e-45
CE27965 [T] KOG0574 STE20-like serine/threonine kinase MST 176 5e-44
CE27726 [T] KOG0574 STE20-like serine/threonine kinase MST 176 5e-44
CE27082 [T] KOG0574 STE20-like serine/threonine kinase MST 176 5e-44
CE07064 [T] KOG0574 STE20-like serine/threonine kinase MST 176 5e-44
SPAC9G1.09 [T] KOG0201 Serine/threonine protein kinase 176 7e-44
7302458 [T] KOG0574 STE20-like serine/threonine kinase MST 174 2e-43
At1g69220 [T] KOG0576 Mitogen-activated protein kinase kinase ki... 174 3e-43
Hs4826878 [T] KOG0582 Ste20-like serine/threonine protein kinase 169 1e-41
YHR102w [T] KOG0201 Serine/threonine protein kinase 164 3e-40
7302511 [T] KOG0576 Mitogen-activated protein kinase kinase kina... 163 6e-40
At4g14480 [T] KOG0582 Ste20-like serine/threonine protein kinase 161 2e-39
At4g24100 [T] KOG0582 Ste20-like serine/threonine protein kinase 159 9e-39
CE26212 [T] KOG0582 Ste20-like serine/threonine protein kinase 158 2e-38
SPBC17F3.02 [T] KOG0201 Serine/threonine protein kinase 156 6e-38
SPBC21.06c [T] KOG0198 MEKK and related serine/threonine protein... 156 7e-38
Hs19923464 [T] KOG0577 Serine/threonine protein kinase 155 1e-37
Hs4505599 [T] KOG0578 p21-activated serine/threonine protein kinase 155 2e-37
Hs5174701 [T] KOG0579 Ste20-like serine/threonine protein kinase 154 2e-37
Hs7706401 [T] KOG0577 Serine/threonine protein kinase 154 3e-37
Hs4759208 [T] KOG0577 Serine/threonine protein kinase 154 3e-37
Hs15451902 [T] KOG0576 Mitogen-activated protein kinase kinase k... 154 4e-37
CE28273 [T] KOG0587 Traf2- and Nck-interacting kinase and relate... 153 5e-37
CE25673 [T] KOG0587 Traf2- and Nck-interacting kinase and relate... 153 5e-37
CE25672 [T] KOG0587 Traf2- and Nck-interacting kinase and relate... 153 5e-37
7291778 [T] KOG0579 Ste20-like serine/threonine protein kinase 153 6e-37
Hs14589909 [T] KOG0576 Mitogen-activated protein kinase kinase k... 152 8e-37
Hs8393810_1 [T] KOG0587 Traf2- and Nck-interacting kinase and re... 152 8e-37
Hs20544910_1 [T] KOG0587 Traf2- and Nck-interacting kinase and r... 152 8e-37
At1g63700 [T] KOG0198 MEKK and related serine/threonine protein ... 152 1e-36
7292249 [T] KOG0587 Traf2- and Nck-interacting kinase and relate... 152 1e-36
7293601 [T] KOG0577 Serine/threonine protein kinase 151 2e-36
Hs7382496 [T] KOG0578 p21-activated serine/threonine protein kinase 150 4e-36
SPBC1604.14c [T] KOG0578 p21-activated serine/threonine protein ... 149 7e-36
Hs7019543 [T] KOG0582 Ste20-like serine/threonine protein kinase 149 7e-36
At5g14720 [T] KOG0582 Ste20-like serine/threonine protein kinase 149 7e-36
Hs22035600 [T] KOG0576 Mitogen-activated protein kinase kinase k... 149 9e-36
CE07905 [T] KOG0579 Ste20-like serine/threonine protein kinase 149 9e-36
At1g54960 [T] KOG0198 MEKK and related serine/threonine protein ... 149 1e-35
Hs7661994 [T] KOG0579 Ste20-like serine/threonine protein kinase 148 2e-35
Hs4505601 [T] KOG0578 p21-activated serine/threonine protein kinase 148 2e-35
HsM4759010 [T] KOG0576 Mitogen-activated protein kinase kinase k... 148 2e-35
At4g10730 [T] KOG0582 Ste20-like serine/threonine protein kinase 148 2e-35
At1g53570 [T] KOG0198 MEKK and related serine/threonine protein ... 148 2e-35
CE07599 [T] KOG0576 Mitogen-activated protein kinase kinase kina... 147 3e-35
HsM4758524 [T] KOG0587 Traf2- and Nck-interacting kinase and rel... 146 8e-35
Hs22035606 [T] KOG0587 Traf2- and Nck-interacting kinase and rel... 146 8e-35
Hs22035604 [T] KOG0587 Traf2- and Nck-interacting kinase and rel... 146 8e-35
Hs22035602 [T] KOG0587 Traf2- and Nck-interacting kinase and rel... 146 8e-35
At3g07980 [T] KOG0198 MEKK and related serine/threonine protein ... 145 1e-34
Hs7657335 [T] KOG0587 Traf2- and Nck-interacting kinase and rela... 145 1e-34
SPAC1F5.09c [T] KOG0578 p21-activated serine/threonine protein k... 145 2e-34
At3g13530 [T] KOG0198 MEKK and related serine/threonine protein ... 144 2e-34
At3g06030 [T] KOG0198 MEKK and related serine/threonine protein ... 144 2e-34
YOR231w [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K) 143 5e-34
CE01405 [T] KOG0577 Serine/threonine protein kinase 143 5e-34
YOL113w [T] KOG0578 p21-activated serine/threonine protein kinase 143 7e-34
SPAC9G1.02 [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 an... 142 9e-34
Hs6005810 [T] KOG0576 Mitogen-activated protein kinase kinase ki... 142 1e-33
At5g66850 [T] KOG0198 MEKK and related serine/threonine protein ... 141 2e-33
7300149 [T] KOG0578 p21-activated serine/threonine protein kinase 141 2e-33
SPBC1D7.05c [T] KOG0198 MEKK and related serine/threonine protei... 141 2e-33
At1g09000 [T] KOG0198 MEKK and related serine/threonine protein ... 141 2e-33
7298926 [T] KOG0578 p21-activated serine/threonine protein kinase 139 9e-33
CE21615 [T] KOG0578 p21-activated serine/threonine protein kinase 138 2e-32
Hs20428779_1 [T] KOG0587 Traf2- and Nck-interacting kinase and r... 137 3e-32
YHL007c [T] KOG0578 p21-activated serine/threonine protein kinase 134 2e-31
At4g08500 [T] KOG0198 MEKK and related serine/threonine protein ... 134 2e-31
Hs4505153 [T] KOG0198 MEKK and related serine/threonine protein ... 134 3e-31
YNL298w [T] KOG0578 p21-activated serine/threonine protein kinase 134 4e-31
CE20564 [T] KOG0578 p21-activated serine/threonine protein kinase 132 9e-31
CE05425 [T] KOG0578 p21-activated serine/threonine protein kinase 132 9e-31
YAR019c [T] KOG0198 MEKK and related serine/threonine protein ki... 132 1e-30
YPL140c [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K) 132 2e-30
Hs22065797 [T] KOG0577 Serine/threonine protein kinase 131 2e-30
At4g26070 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 131 2e-30
Hs4507275 [D] KOG0580 Serine/threonine protein kinase 130 3e-30
HsM4507279 [D] KOG0580 Serine/threonine protein kinase 129 7e-30
CE27670 [T] KOG0578 p21-activated serine/threonine protein kinase 129 7e-30
At3g61960 [OUT] KOG0595 Serine/threonine-protein kinase involved... 129 1e-29
Hs9910476 [T] KOG0578 p21-activated serine/threonine protein kinase 129 1e-29
SPAC1F3.02c [T] KOG0198 MEKK and related serine/threonine protei... 128 2e-29
Hs20479818 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase ... 128 2e-29
Hs14771959 [T] KOG0578 p21-activated serine/threonine protein ki... 128 2e-29
YPL150w [T] KOG0583 Serine/threonine protein kinase 127 4e-29
At4g29810 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 127 4e-29
Hs5031975 [T] KOG0578 p21-activated serine/threonine protein kinase 127 5e-29
YJL095w [T] KOG0198 MEKK and related serine/threonine protein ki... 126 8e-29
SPAC23C11.16 [D] KOG0575 Polo-like serine/threonine protein kinase 126 8e-29
YCR073c [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and r... 125 1e-28
Hs18602554 [T] KOG0578 p21-activated serine/threonine protein ki... 125 2e-28
YNR031c [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and r... 124 4e-28
HsM5729922 [T] KOG0198 MEKK and related serine/threonine protein... 124 4e-28
Hs4507273 [D] KOG0580 Serine/threonine protein kinase 123 5e-28
7302570 [R] KOG0586 Serine/threonine protein kinase 123 5e-28
YMR001c [D] KOG0575 Polo-like serine/threonine protein kinase 123 7e-28
At4g08480 [T] KOG0198 MEKK and related serine/threonine protein ... 123 7e-28
YLR362w [T] KOG0198 MEKK and related serine/threonine protein ki... 122 9e-28
At4g08470 [T] KOG0198 MEKK and related serine/threonine protein ... 122 9e-28
Hs5453978 [T] KOG0614 cGMP-dependent protein kinase 122 2e-27
Hs22065589 [T] KOG0587 Traf2- and Nck-interacting kinase and rel... 122 2e-27
SPCC320.12c [D] KOG0580 Serine/threonine protein kinase 121 2e-27
Hs4502553 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 121 2e-27
Hs10835242 [T] KOG0614 cGMP-dependent protein kinase 121 2e-27
Hs9845489 [R] KOG0586 Serine/threonine protein kinase 121 3e-27
Hs9845487 [R] KOG0586 Serine/threonine protein kinase 121 3e-27
Hs22062450 [R] KOG0586 Serine/threonine protein kinase 121 3e-27
Hs21735556 [T] KOG0198 MEKK and related serine/threonine protein... 121 3e-27
At1g70430 [T] KOG0582 Ste20-like serine/threonine protein kinase 121 3e-27
Hs18552621 [R] KOG0597 Serine-threonine protein kinase FUSED 120 3e-27
At1g23700 [T] KOG0582 Ste20-like serine/threonine protein kinase 120 3e-27
CE28479 [T] KOG0583 Serine/threonine protein kinase 120 5e-27
At2g45490 [D] KOG0580 Serine/threonine protein kinase 120 6e-27
Hs6031180 [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and... 119 8e-27
Hs5803088 [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and... 119 8e-27
SPBC409.07c [T] KOG0581 Mitogen-activated protein kinase kinase ... 118 2e-26
HsM4505103 [R] KOG0586 Serine/threonine protein kinase 118 2e-26
Hs21359873 [D] KOG0575 Polo-like serine/threonine protein kinase 118 2e-26
HsM4826916 [D] KOG0575 Polo-like serine/threonine protein kinase 118 2e-26
7297240_1 [T] KOG0587 Traf2- and Nck-interacting kinase and rela... 118 2e-26
CE27768 [R] KOG0586 Serine/threonine protein kinase 117 4e-26
CE23838 [R] KOG0586 Serine/threonine protein kinase 117 4e-26
At3g20860 [R] KOG0589 Serine/threonine protein kinase 117 4e-26
YJL128c [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K) 117 5e-26
SPAC890.03 [T] KOG0583 Serine/threonine protein kinase 117 5e-26
CE17284 [T] KOG0583 Serine/threonine protein kinase 117 5e-26
Hs5730055 [D] KOG0575 Polo-like serine/threonine protein kinase 116 7e-26
At4g32830 [D] KOG0580 Serine/threonine protein kinase 116 7e-26
7299160 [OUT] KOG0595 Serine/threonine-protein kinase involved i... 116 7e-26
7296166 [T] KOG0614 cGMP-dependent protein kinase 116 7e-26
SPBC543.07 [T] KOG0581 Mitogen-activated protein kinase kinase (... 115 1e-25
Hs5453976 [T] KOG0694 Serine/threonine protein kinase 115 1e-25
Hs13899225 [R] KOG0586 Serine/threonine protein kinase 115 1e-25
7302464 [R] KOG0586 Serine/threonine protein kinase 115 1e-25
7292679 [G] KOG0599 Phosphorylase kinase gamma subunit 115 1e-25
7291037 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K) 115 1e-25
Hs13569922 [R] KOG0611 Predicted serine/threonine protein kinase 115 1e-25
SPBC106.10 [T] KOG0616 cAMP-dependent protein kinase catalytic s... 115 2e-25
Hs4507277_1 [R] KOG0589 Serine/threonine protein kinase 114 2e-25
7293666 [D] KOG0575 Polo-like serine/threonine protein kinase 114 3e-25
CE17354 [T] KOG0694 Serine/threonine protein kinase 114 4e-25
CE17353 [T] KOG0694 Serine/threonine protein kinase 114 4e-25
Hs9966875 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 113 6e-25
Hs8923922 [R] KOG0586 Serine/threonine protein kinase 113 6e-25
At1g79640 [T] KOG0582 Ste20-like serine/threonine protein kinase 113 6e-25
Hs4759178 [D] KOG0580 Serine/threonine protein kinase 113 7e-25
At1g50230 [R] KOG0597 Serine-threonine protein kinase FUSED 113 7e-25
At3g08730 [RT] KOG0598 Ribosomal protein S6 kinase and related p... 112 9e-25
Hs4885563 [T] KOG0694 Serine/threonine protein kinase 112 1e-24
At4g26890 [T] KOG0198 MEKK and related serine/threonine protein ... 112 1e-24
YJL164c [T] KOG0616 cAMP-dependent protein kinase catalytic subu... 112 2e-24
ECU07g0360 [D] KOG0580 Serine/threonine protein kinase 112 2e-24
7297611 [T] KOG0614 cGMP-dependent protein kinase 112 2e-24
7290249 [R] KOG0586 Serine/threonine protein kinase 112 2e-24
YKL166c [T] KOG0616 cAMP-dependent protein kinase catalytic subu... 111 2e-24
At3g04810 [R] KOG0589 Serine/threonine protein kinase 111 2e-24
SPCC18B5.11c [D] KOG0615 Serine/threonine protein kinase Chk2 an... 111 3e-24
SPAC17G8.14c [T] KOG0694 Serine/threonine protein kinase 110 4e-24
Hs5579478 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 110 4e-24
Hs4505695 [T] KOG0592 3-phosphoinositide-dependent protein kinas... 110 4e-24
CE24761 [D] KOG0580 Serine/threonine protein kinase 110 4e-24
At3g08720 [RT] KOG0598 Ribosomal protein S6 kinase and related p... 110 4e-24
At1g07150 [T] KOG0198 MEKK and related serine/threonine protein ... 110 4e-24
Hs14728804 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase ... 110 5e-24
7299322 [R] KOG0611 Predicted serine/threonine protein kinase 110 5e-24
At5g56580 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 110 6e-24
7301734 [T] KOG0694 Serine/threonine protein kinase 110 6e-24
At4g12020_6 [T] KOG0198 MEKK and related serine/threonine protei... 110 6e-24
YPL209c [D] KOG0580 Serine/threonine protein kinase 109 8e-24
Hs7662170 [R] KOG0611 Predicted serine/threonine protein kinase 109 8e-24
CE24941 [T] KOG0983 Mitogen-activated protein kinase (MAPK) kina... 109 8e-24
At2g25880 [D] KOG0580 Serine/threonine protein kinase 109 8e-24
At1g54510 [R] KOG0589 Serine/threonine protein kinase 109 8e-24
Hs21729895 [T] KOG0581 Mitogen-activated protein kinase kinase (... 109 1e-23
At5g28290 [R] KOG0589 Serine/threonine protein kinase 109 1e-23
Hs4507831 [OUT] KOG0595 Serine/threonine-protein kinase involved... 108 1e-23
Hs20535816 [T] KOG0695 Serine/threonine protein kinase 108 2e-23
Hs10864650 [T] KOG0695 Serine/threonine protein kinase 108 2e-23
7296450 [D] KOG0575 Polo-like serine/threonine protein kinase 108 2e-23
Hs4557511 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 108 2e-23
Hs21361133 [R] KOG0586 Serine/threonine protein kinase 108 2e-23
Hs14196445 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase ... 108 2e-23
Hs13489054 [T] KOG0581 Mitogen-activated protein kinase kinase (... 108 2e-23
YOR351c [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-... 107 3e-23
CE14798 [RT] KOG0598 Ribosomal protein S6 kinase and related pro... 107 3e-23
Hs22050308_2 [T] KOG0198 MEKK and related serine/threonine prote... 107 3e-23
Hs20547806 [R] KOG0589 Serine/threonine protein kinase 107 4e-23
ECU01g0630 [D] KOG0575 Polo-like serine/threonine protein kinase 107 4e-23
CE23001 [R] KOG0589 Serine/threonine protein kinase 107 4e-23
At2g34180 [T] KOG0583 Serine/threonine protein kinase 107 4e-23
YOL016c [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-... 107 5e-23
Hs4502023 [T] KOG0690 Serine/threonine protein kinase 107 5e-23
Hs19424132 [D] KOG0591 NIMA (never in mitosis)-related G2-specif... 107 5e-23
At5g40440 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 107 5e-23
7302861 [T] KOG0696 Serine/threonine protein kinase 107 5e-23
7299437 [R] KOG0586 Serine/threonine protein kinase 107 5e-23
CE29092 [T] KOG0694 Serine/threonine protein kinase 106 7e-23
CE05780 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-... 106 7e-23
7302860 [T] KOG0696 Serine/threonine protein kinase 106 7e-23
CE26793_1 [R] KOG0611 Predicted serine/threonine protein kinase 106 7e-23
YNR047w [R] KOG0610 Putative serine/threonine protein kinase 106 9e-23
SPAC1B9.02c [RT] KOG0598 Ribosomal protein S6 kinase and related... 106 9e-23
Hs20550407 [T] KOG0201 Serine/threonine protein kinase 106 9e-23
CE21025 [D] KOG0580 Serine/threonine protein kinase 106 9e-23
At5g62310 [TR] KOG0606 Microtubule-associated serine/threonine k... 106 9e-23
At2g32510 [T] KOG0198 MEKK and related serine/threonine protein ... 106 9e-23
At1g49180_1 [OUT] KOG0595 Serine/threonine-protein kinase involv... 106 9e-23
YMR104c [RT] KOG0598 Ribosomal protein S6 kinase and related pro... 105 1e-22
Hs4885061 [T] KOG0690 Serine/threonine protein kinase 105 1e-22
CE25046 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-... 105 1e-22
YGL179c [T] KOG0585 Ca2+/calmodulin-dependent protein kinase kin... 105 2e-22
7300435 [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and r... 105 2e-22
HsM5454184 [T] KOG4721 Serine/threonine protein kinase contains ... 105 2e-22
Hs7662210 [OUT] KOG0595 Serine/threonine-protein kinase involved... 105 2e-22
Hs4506737 [RT] KOG0598 Ribosomal protein S6 kinase and related p... 105 2e-22
Hs21735552 [T] KOG4721 Serine/threonine protein kinase contains ... 105 2e-22
Hs15619015 [T] KOG0616 cAMP-dependent protein kinase catalytic s... 105 2e-22
CE04724 [T] KOG0983 Mitogen-activated protein kinase (MAPK) kina... 105 2e-22
Hs21735544 [T] KOG0983 Mitogen-activated protein kinase (MAPK) k... 104 3e-22
Hs4506101 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 104 3e-22
Hs21729897 [T] KOG0581 Mitogen-activated protein kinase kinase (... 104 3e-22
CE03979 [T] KOG0614 cGMP-dependent protein kinase 104 3e-22
7299438 [R] KOG0586 Serine/threonine protein kinase 104 3e-22
YPL203w [T] KOG0616 cAMP-dependent protein kinase catalytic subu... 103 4e-22
Hs5174547 [T] KOG4279 Serine/threonine protein kinase 103 4e-22
Hs4506071 [T] KOG0695 Serine/threonine protein kinase 103 4e-22
Hs20545245 [D] KOG0588 Serine/threonine protein kinase 103 4e-22
7301213 [R] KOG0589 Serine/threonine protein kinase 103 4e-22
YDR507c [D] KOG0588 Serine/threonine protein kinase 103 6e-22
Hs14770402 [R] KOG0586 Serine/threonine protein kinase 103 6e-22
CE19898 [T] KOG0614 cGMP-dependent protein kinase 103 6e-22
CE19897 [T] KOG0614 cGMP-dependent protein kinase 103 6e-22
At4g35780 [T] KOG0192 Tyrosine kinase specific for activated (GT... 103 6e-22
At3g06620 [T] KOG0192 Tyrosine kinase specific for activated (GT... 103 6e-22
At2g17700 [T] KOG0192 Tyrosine kinase specific for activated (GT... 103 6e-22
Hs5453966 [T] KOG0583 Serine/threonine protein kinase 103 7e-22
Hs21735542 [T] KOG0983 Mitogen-activated protein kinase (MAPK) k... 103 7e-22
At1g45160 [TR] KOG0606 Microtubule-associated serine/threonine k... 103 7e-22
Hs4885549 [T] KOG0690 Serine/threonine protein kinase 102 1e-21
Hs4506739 [RT] KOG0598 Ribosomal protein S6 kinase and related p... 102 1e-21
At3g06640 [T] KOG0192 Tyrosine kinase specific for activated (GT... 102 1e-21
Hs19311016_1 [R] KOG0589 Serine/threonine protein kinase 102 1e-21
Hs7661974 [T] KOG0583 Serine/threonine protein kinase 102 1e-21
CE24516 [OUT] KOG0595 Serine/threonine-protein kinase involved i... 102 1e-21
At5g55090 [T] KOG0198 MEKK and related serine/threonine protein ... 102 1e-21
SPAC1D4.13 [T] KOG0581 Mitogen-activated protein kinase kinase (... 102 2e-21
Hs5453970 [T] KOG0694 Serine/threonine protein kinase 102 2e-21
Hs4759052 [T] KOG0603 Ribosomal protein S6 kinase 102 2e-21
CE18169 [T] KOG0603 Ribosomal protein S6 kinase 102 2e-21
CE13014 [T] KOG0603 Ribosomal protein S6 kinase 102 2e-21
Hs19923407 [D] KOG0591 NIMA (never in mitosis)-related G2-specif... 101 2e-21
CE07737 [T] KOG0198 MEKK and related serine/threonine protein ki... 101 2e-21
7295426 [RT] KOG0598 Ribosomal protein S6 kinase and related pro... 101 2e-21
Hs4758016 [D] KOG0575 Polo-like serine/threonine protein kinase 101 3e-21
Hs4506055 [T] KOG0616 cAMP-dependent protein kinase catalytic su... 101 3e-21
At5g39440 [T] KOG0583 Serine/threonine protein kinase 101 3e-21
SPCC4G3.08 [RT] KOG0598 Ribosomal protein S6 kinase and related ... 100 4e-21
Hs14735945 [T] KOG0694 Serine/threonine protein kinase 100 4e-21
CE27573 [T] KOG0198 MEKK and related serine/threonine protein ki... 100 4e-21
CE05507 [T] KOG0603 Ribosomal protein S6 kinase 100 4e-21
7303915 [T] KOG0694 Serine/threonine protein kinase 100 4e-21
7303914 [T] KOG0694 Serine/threonine protein kinase 100 4e-21
SPBC12D12.04c [T] KOG0694 Serine/threonine protein kinase 100 5e-21
Hs4506067 [T] KOG0696 Serine/threonine protein kinase 100 5e-21
CE28744 [RT] KOG0598 Ribosomal protein S6 kinase and related pro... 100 5e-21
At1g29230 [T] KOG0583 Serine/threonine protein kinase 100 5e-21
7300559 [T] KOG4279 Serine/threonine protein kinase 100 5e-21
7293496 [R] KOG0597 Serine-threonine protein kinase FUSED 100 5e-21
YBL105c [T] KOG0694 Serine/threonine protein kinase 100 6e-21
SPCC74.03c [T] KOG0583 Serine/threonine protein kinase 100 6e-21
At3g49370 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 100 6e-21
At3g17850 [TR] KOG0606 Microtubule-associated serine/threonine k... 100 6e-21
At1g67580 [R] KOG0663 Protein kinase PITSLRE and related kinases 100 6e-21
Hs4826948 [T] KOG0616 cAMP-dependent protein kinase catalytic su... 100 8e-21
Hs4506057 [T] KOG0616 cAMP-dependent protein kinase catalytic su... 100 8e-21
CE02604 [T] KOG0695 Serine/threonine protein kinase 100 8e-21
7303019 [Z] KOG0613 Projectin/twitchin and related proteins 100 8e-21
7300106 [T] KOG0690 Serine/threonine protein kinase 100 8e-21
7294217 [D] KOG0588 Serine/threonine protein kinase 100 8e-21
Hs4758194 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 99 1e-20
Hs4506889 [T] KOG1006 Mitogen-activated protein kinase (MAPK) ki... 99 1e-20
CE26649 [D] KOG0575 Polo-like serine/threonine protein kinase 99 1e-20
At5g01810 [T] KOG0583 Serine/threonine protein kinase 99 1e-20
7299536 [D] KOG0580 Serine/threonine protein kinase 99 1e-20
7292830 [T] KOG0984 Mitogen-activated protein kinase (MAPK) kina... 99 1e-20
Hs4759050 [T] KOG0603 Ribosomal protein S6 kinase 99 1e-20
Hs13384594 [T] KOG0696 Serine/threonine protein kinase 99 1e-20
CE07285 [D] KOG0575 Polo-like serine/threonine protein kinase 99 1e-20
At3g01090 [T] KOG0583 Serine/threonine protein kinase 99 1e-20
At2g37840 [OUT] KOG0595 Serine/threonine-protein kinase involved... 99 1e-20
At2g30040 [T] KOG0198 MEKK and related serine/threonine protein ... 99 1e-20
At2g20470 [R] KOG0605 NDR and related serine/threonine kinases 99 1e-20
7304311 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-... 99 1e-20
7290841 [D] KOG0591 NIMA (never in mitosis)-related G2-specific ... 99 1e-20
YPL153c [D] KOG0615 Serine/threonine protein kinase Chk2 and rel... 99 2e-20
YCR091w [R] KOG0610 Putative serine/threonine protein kinase 99 2e-20
SPCC24B10.07 [RT] KOG0598 Ribosomal protein S6 kinase and relate... 99 2e-20
Hs14916455 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase ... 99 2e-20
CE28218 [D] KOG0588 Serine/threonine protein kinase 99 2e-20
YCL024w [T] KOG0583 Serine/threonine protein kinase 98 2e-20
SPAC57A10.02 [D] KOG0588 Serine/threonine protein kinase 98 2e-20
SPAC23H4.02 [T] KOG0583 Serine/threonine protein kinase 98 2e-20
CE28760 [R] KOG0605 NDR and related serine/threonine kinases 98 2e-20
CE15475 [T] KOG0616 cAMP-dependent protein kinase catalytic subu... 98 2e-20
CE15473 [T] KOG0616 cAMP-dependent protein kinase catalytic subu... 98 2e-20
CE27894_1 [R] KOG0589 Serine/threonine protein kinase 98 2e-20
YLR096w [T] KOG0583 Serine/threonine protein kinase 98 3e-20
SPBC4F6.06 [T] KOG0583 Serine/threonine protein kinase 98 3e-20
Hs5032091 [RT] KOG0598 Ribosomal protein S6 kinase and related p... 98 3e-20
Hs4758696 [T] KOG4721 Serine/threonine protein kinase contains l... 98 3e-20
At3g29160 [T] KOG0583 Serine/threonine protein kinase 98 3e-20
7295638 [T] KOG0603 Ribosomal protein S6 kinase 98 3e-20
YDR122w [T] KOG0583 Serine/threonine protein kinase 97 4e-20
SPCC162.10 [RT] KOG0598 Ribosomal protein S6 kinase and related ... 97 4e-20
Hs4505785 [G] KOG0599 Phosphorylase kinase gamma subunit 97 4e-20
CE25437 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K) 97 4e-20
CE23702 [T] KOG4721 Serine/threonine protein kinase contains leu... 97 4e-20
Hs21361433 [D] KOG0575 Polo-like serine/threonine protein kinase 97 5e-20
At5g45820 [T] KOG0583 Serine/threonine protein kinase 97 5e-20
At3g50530 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 97 5e-20
YDR490c [T] KOG0592 3-phosphoinositide-dependent protein kinase ... 97 7e-20
Hs5453964 [T] KOG0583 Serine/threonine protein kinase 97 7e-20
Hs21361643 [T] KOG4717 Serine/threonine protein kinase 97 7e-20
Hs14150045 [T] KOG0585 Ca2+/calmodulin-dependent protein kinase ... 97 7e-20
Hs13376582 [T] KOG0198 MEKK and related serine/threonine protein... 97 7e-20
CE16081 [T] KOG0583 Serine/threonine protein kinase 97 7e-20
CE04603 [T] KOG0616 cAMP-dependent protein kinase catalytic subu... 97 7e-20
At5g19450 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 97 7e-20
At2g41860 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 97 7e-20
7294537 [OUT] KOG0595 Serine/threonine-protein kinase involved i... 97 7e-20
Hs4826684_1 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase... 97 7e-20
YDR466w [T] KOG0592 3-phosphoinositide-dependent protein kinase ... 96 9e-20
SPAC14C4.03 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase... 96 9e-20
Hs5453974 [T] KOG0694 Serine/threonine protein kinase 96 9e-20
CE03492 [RT] KOG0598 Ribosomal protein S6 kinase and related pro... 96 9e-20
At5g24430 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 96 9e-20
At4g04720 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 96 9e-20
HsM7657627 [D] KOG0575 Polo-like serine/threonine protein kinase 96 1e-19
Hs4506735 [T] KOG0603 Ribosomal protein S6 kinase 96 1e-19
Hs20545357 [T] KOG0583 Serine/threonine protein kinase 96 1e-19
Hs14770985 [T] KOG0582 Ste20-like serine/threonine protein kinase 96 1e-19
CE29298 [T] KOG0690 Serine/threonine protein kinase 96 1e-19
CE18699 [T] KOG0694 Serine/threonine protein kinase 96 1e-19
CE18646 [T] KOG0690 Serine/threonine protein kinase 96 1e-19
At5g58380 [T] KOG0583 Serine/threonine protein kinase 96 1e-19
At5g20930 [T] KOG1151 Tousled-like protein kinase 96 1e-19
7298652 [D] KOG0615 Serine/threonine protein kinase Chk2 and rel... 96 1e-19
7294770 [T] KOG0603 Ribosomal protein S6 kinase 96 1e-19
YOL100w [T] KOG0592 3-phosphoinositide-dependent protein kinase ... 96 2e-19
SPACUNK12.02c [T] KOG0032 Ca2+/calmodulin-dependent protein kina... 96 2e-19
Hs4758078 [T] KOG0197 Tyrosine kinases 96 2e-19
Hs20149547 [T] KOG0603 Ribosomal protein S6 kinase 96 2e-19
Hs19923570 [T] KOG0603 Ribosomal protein S6 kinase 96 2e-19
CE27177 [T] KOG4279 Serine/threonine protein kinase 96 2e-19
Hs5453972 [T] KOG0694 Serine/threonine protein kinase 95 2e-19
Hs21729899 [T] KOG0581 Mitogen-activated protein kinase kinase (... 95 2e-19
CE18967 [T] KOG4236 Serine/threonine protein kinase PKC mu/PKD a... 95 2e-19
CE02586 [T] KOG0696 Serine/threonine protein kinase 95 2e-19
CE02074 [T] KOG0986 G protein-coupled receptor kinase 95 2e-19
CE00847 [T] KOG0583 Serine/threonine protein kinase 95 2e-19
At1g51660 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 95 2e-19
YDL159w [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K) 95 3e-19
Hs7657214 [T] KOG0583 Serine/threonine protein kinase 95 3e-19
At2g25090 [T] KOG0583 Serine/threonine protein kinase 95 3e-19
7304283 [Z] KOG0613 Projectin/twitchin and related proteins 95 3e-19
7297776 [D] KOG0580 Serine/threonine protein kinase 95 3e-19
7297542 [T] KOG0616 cAMP-dependent protein kinase catalytic subu... 95 3e-19
7290313 [T] KOG0193 Serine/threonine protein kinase RAF 95 3e-19
Hs4758192 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 94 3e-19
At5g35410 [T] KOG0583 Serine/threonine protein kinase 94 3e-19
At5g25110 [T] KOG0583 Serine/threonine protein kinase 94 3e-19
At4g18700 [T] KOG0583 Serine/threonine protein kinase 94 3e-19
At4g04740 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 94 3e-19
At2g46700 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 94 3e-19
At1g14000 [T] KOG0192 Tyrosine kinase specific for activated (GT... 94 3e-19
Hs20547878 [R] KOG0589 Serine/threonine protein kinase 94 5e-19
CE06635 [Z] KOG0613 Projectin/twitchin and related proteins 94 5e-19
CE06634 [Z] KOG0613 Projectin/twitchin and related proteins 94 5e-19
At3g21220 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 94 5e-19
At2g35890 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 94 5e-19
At1g73500 [T] KOG0581 Mitogen-activated protein kinase kinase (M... 94 5e-19
At1g12680 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 94 5e-19
YHR205w [RT] KOG0598 Ribosomal protein S6 kinase and related pro... 94 6e-19
Hs4506073 [T] KOG0694 Serine/threonine protein kinase 94 6e-19
Hs14758219 [T] KOG0694 Serine/threonine protein kinase 94 6e-19
At3g44200 [R] KOG0589 Serine/threonine protein kinase 94 6e-19
YKL126w [RT] KOG0598 Ribosomal protein S6 kinase and related pro... 93 8e-19
Hs4758652 [R] KOG0593 Predicted protein kinase KKIAMRE 93 8e-19
Hs4506529 [T] KOG0986 G protein-coupled receptor kinase 93 8e-19
CE22045 [RT] KOG0598 Ribosomal protein S6 kinase and related pro... 93 8e-19
At5g23580 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 93 8e-19
At2g26980 [T] KOG0583 Serine/threonine protein kinase 93 8e-19
At1g30270 [T] KOG0583 Serine/threonine protein kinase 93 8e-19
7290147 [T] KOG0583 Serine/threonine protein kinase 93 8e-19
Hs20070247_2 [RT] KOG0598 Ribosomal protein S6 kinase and relate... 93 8e-19
Hs8923754 [RT] KOG0598 Ribosomal protein S6 kinase and related p... 93 1e-18
Hs22068916 [T] KOG0696 Serine/threonine protein kinase 93 1e-18
Hs20127450 [T] KOG0696 Serine/threonine protein kinase 93 1e-18
Hs16507245 [T] KOG0583 Serine/threonine protein kinase 93 1e-18
Hs14776113 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase ... 93 1e-18
CE28643 [T] KOG0583 Serine/threonine protein kinase 93 1e-18
CE07458 [T] KOG0583 Serine/threonine protein kinase 93 1e-18
7303111 [T] KOG0695 Serine/threonine protein kinase 93 1e-18
7290150 [T] KOG0583 Serine/threonine protein kinase 93 1e-18
YDR477w [T] KOG0583 Serine/threonine protein kinase 92 1e-18
SPAC2F3.15 [D] KOG0600 Cdc2-related protein kinase 92 1e-18
Hs7657526 [T] KOG0603 Ribosomal protein S6 kinase 92 1e-18
Hs14754789 [OUT] KOG0595 Serine/threonine-protein kinase involve... 92 1e-18
CE01554 [T] KOG0986 G protein-coupled receptor kinase 92 1e-18
At5g04510 [T] KOG0592 3-phosphoinositide-dependent protein kinas... 92 1e-18
At1g08720 [T] KOG0192 Tyrosine kinase specific for activated (GT... 92 1e-18
7293761 [T] KOG4721 Serine/threonine protein kinase contains leu... 92 1e-18
Hs22045241 [T] KOG0578 p21-activated serine/threonine protein ki... 92 2e-18
Hs20127541 [RT] KOG0598 Ribosomal protein S6 kinase and related ... 92 2e-18
Hs17933758 [T] KOG0585 Ca2+/calmodulin-dependent protein kinase ... 92 2e-18
At3g23000 [T] KOG0583 Serine/threonine protein kinase 92 2e-18
At3g06630 [T] KOG0192 Tyrosine kinase specific for activated (GT... 92 2e-18
At1g76040 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 92 2e-18
Hs16950621 [Z] KOG0613 Projectin/twitchin and related proteins 92 2e-18
Hs16950613 [Z] KOG0613 Projectin/twitchin and related proteins 92 2e-18
Hs16950611 [Z] KOG0613 Projectin/twitchin and related proteins 92 2e-18
Hs16950601 [Z] KOG0613 Projectin/twitchin and related proteins 92 2e-18
Hs14042947 [T] KOG0583 Serine/threonine protein kinase 92 2e-18
CE22877 [D] KOG0575 Polo-like serine/threonine protein kinase 92 2e-18
CE17343 [T] KOG0583 Serine/threonine protein kinase 92 2e-18
CE07156 [RT] KOG0598 Ribosomal protein S6 kinase and related pro... 92 2e-18
At5g45810 [T] KOG0583 Serine/threonine protein kinase 92 2e-18
At4g23050 [T] KOG0192 Tyrosine kinase specific for activated (GT... 92 2e-18
At3g50500 [T] KOG0583 Serine/threonine protein kinase 92 2e-18
At1g61950 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 92 2e-18
At1g08650 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 92 2e-18
7292829 [T] KOG0983 Mitogen-activated protein kinase (MAPK) kina... 92 2e-18
SPAC22E12.14c [RT] KOG0598 Ribosomal protein S6 kinase and relat... 91 3e-18
CE15612 [T] KOG0690 Serine/threonine protein kinase 91 3e-18
At5g39420 [D] KOG0600 Cdc2-related protein kinase 91 3e-18
At5g12180 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 91 3e-18
At2g38910 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 91 3e-18
At1g18160 [T] KOG0192 Tyrosine kinase specific for activated (GT... 91 3e-18
Hs4502567_1 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase... 91 3e-18
7291742_1 [T] KOG0612 Rho-associated coiled-coil containing prot... 91 3e-18
SPCC576.15c [T] KOG0592 3-phosphoinositide-dependent protein kin... 91 4e-18
ECU07g0520 [T] KOG0616 cAMP-dependent protein kinase catalytic s... 91 4e-18
CE27583 [T] KOG0604 MAP kinase-activated protein kinase 2 91 4e-18
CE18608 [R] KOG0594 Protein kinase PCTAIRE and related kinases 91 4e-18
CE17545 [T] KOG0604 MAP kinase-activated protein kinase 2 91 4e-18
CE06686 [T] KOG0660 Mitogen-activated protein kinase 91 4e-18
At2g17890 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 91 4e-18
7291707 [T] KOG1152 Signal transduction serine/threonine kinase ... 91 4e-18
Hs4759044 [T] KOG0612 Rho-associated coiled-coil containing prot... 91 5e-18
Hs20536595 [T] KOG0612 Rho-associated coiled-coil containing pro... 91 5e-18
Hs14042966 [T] KOG0583 Serine/threonine protein kinase 91 5e-18
Hs10835065 [T] KOG0616 cAMP-dependent protein kinase catalytic s... 91 5e-18
CE10328 [T] KOG1006 Mitogen-activated protein kinase (MAPK) kina... 91 5e-18
CE08098 [T] KOG0612 Rho-associated coiled-coil containing protei... 91 5e-18
CE02377 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-... 91 5e-18
At4g33950 [T] KOG0583 Serine/threonine protein kinase 91 5e-18
At4g24400 [T] KOG0583 Serine/threonine protein kinase 91 5e-18
At3g10540 [T] KOG0592 3-phosphoinositide-dependent protein kinas... 90 7e-18
At1g12580 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 90 7e-18
7299057 [T] KOG1006 Mitogen-activated protein kinase (MAPK) kina... 90 7e-18
YPL141c [T] KOG0583 Serine/threonine protein kinase 90 9e-18
Hs7019489 [T] KOG0694 Serine/threonine protein kinase 90 9e-18
CE15235 [R] KOG0589 Serine/threonine protein kinase 90 9e-18
At3g19100 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 90 9e-18
At2g24360 [T] KOG0192 Tyrosine kinase specific for activated (GT... 90 9e-18
At1g74330 [D] KOG0600 Cdc2-related protein kinase 90 9e-18
Hs4885583 [T] KOG0612 Rho-associated coiled-coil containing prot... 89 1e-17
Hs14589902 [T] KOG0984 Mitogen-activated protein kinase (MAPK) k... 89 1e-17
ECU03g0980 [T] KOG0583 Serine/threonine protein kinase 89 1e-17
CE27166 [T] KOG0616 cAMP-dependent protein kinase catalytic subu... 89 1e-17
At3g50310 [T] KOG0198 MEKK and related serine/threonine protein ... 89 1e-17
At2g42630 [T] KOG0192 Tyrosine kinase specific for activated (GT... 89 1e-17
At2g38490 [T] KOG0583 Serine/threonine protein kinase 89 1e-17
At1g05100 [T] KOG0198 MEKK and related serine/threonine protein ... 89 1e-17
YOR233w [T] KOG0583 Serine/threonine protein kinase 89 1e-17
SPAC19E9.02 [D] KOG0591 NIMA (never in mitosis)-related G2-speci... 89 1e-17
Hs14589900 [T] KOG0984 Mitogen-activated protein kinase (MAPK) k... 89 1e-17
At5g67080 [T] KOG0198 MEKK and related serine/threonine protein ... 89 1e-17
At5g66880 [T] KOG0583 Serine/threonine protein kinase 89 1e-17
At5g19360 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase E... 89 1e-17
At5g10930 [T] KOG0583 Serine/threonine protein kinase 89 1e-17
SPCC1259.13 [D] KOG0590 Checkpoint kinase and related serine/thr... 89 2e-17
Hs4502435 [T] KOG0197 Tyrosine kinases 89 2e-17
Hs20986512 [T] KOG0660 Mitogen-activated protein kinase 89 2e-17
CE28059 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-... 89 2e-17
CE28057 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-... 89 2e-17
CE28054 [T] KOG0033 Ca2+/calmodulin-dependent protein kinase EF-... 89 2e-17
>YDR523c [T] KOG0201 Serine/threonine protein kinase
Length = 490
Score = 256 bits (655), Expect = 4e-68
Identities = 159/492 (32%), Positives = 255/492 (51%), Gaps = 40/492 (8%)
Query: 7 FQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEIY 66
+ + C+G+GNFGDVY A ++ + + +AIK +NLEHS+E I+LL +EI+
Sbjct: 18 YSIQSCIGRGNFGDVYKAV----------DRVTQEI-VAIKVVNLEHSDEDIELLAQEIF 66
Query: 67 FLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXX--TEQTTCFIILQVC 124
FL+ L P IT+Y T D +++IVMEYC E+ FII +V
Sbjct: 67 FLAELKSPLITNYIATMLEDVSMWIVMEYCGGGSCSDLLKRSYVNGLPEEKVSFIIHEVT 126
Query: 125 HALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPF 184
L+YLHE+R IHRD+KAANILLN++G V+L D GV+G ++ R +TFVGTP+
Sbjct: 127 LGLKYLHEQRKIHRDIKAANILLNEEGMVKLGDFGVSGHIRSTLKR------DTFVGTPY 180
Query: 185 WMAPEII--KNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRN 242
WMAPE++ + Y+ K DIWSLGITT ELL G PP+S D MK + +PK +
Sbjct: 181 WMAPEVVCCEVDGYNEKADIWSLGITTYELLKGLPPLSKYDPMKVMTNLPKRKPPKL--Q 238
Query: 243 MDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKKCSITNIMEEITVMKTNQILSKEKP 302
S KDF+ CL + P RP+ LL +++K +ITN+ ++ ++K ++ ++
Sbjct: 239 GPFSDAAKDFVAGCLVKTPADRPSAYNLLSFEFVKNITITNLKSDVDLIKQKKV---QER 295
Query: 303 RSCKPRFPLSDKVYK-TNLPNQLESWRFEDESVLRFD-GLGDIPNLYXXXXXXXXXXXSP 360
+ P++PL +++YK +N E W FE + ++ + SP
Sbjct: 296 YTKVPKYPLQNRLYKNSNTVRGKEFWNFESTRLSTTQISKEELSPITQDSPTSSLNMESP 355
Query: 361 LLTKQQLRTPNISTPTSA----LSPTSMAISPKTNLSTPATESYEDVSSSPSEQKMKLGH 416
L Q TP I+ P+S+ + + ++ + + + P K
Sbjct: 356 YLLHGQTVTP-ITNPSSSSFRKCTQPVFELDSGMDIDSGCPNAQAETEIVPLSNHNKKHK 414
Query: 417 EN-------QNIDYWKDVFLYSLKKVRQRAINEPTKETVKSLTRYMGDLEKDFPGLSEAL 469
+N + DY K++ + L ++ RA ++ T++ V + + E + PG +E
Sbjct: 415 KNDIQALKIEKFDYLKNIVSHILNRMYDRARDDETRKYVNEMLKQFIKTEANVPGFNEVF 474
Query: 470 VQEISTRVAKLK 481
++EIS R+ +K
Sbjct: 475 IEEISLRIEAIK 486
>Hs20070158 [T] KOG0201 Serine/threonine protein kinase
Length = 443
Score = 212 bits (540), Expect = 9e-55
Identities = 121/283 (42%), Positives = 169/283 (58%), Gaps = 20/283 (7%)
Query: 7 FQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEIY 66
F LE +GKG+FG+V+ + D + K V AIK I+LE + + I+ + +EI
Sbjct: 36 FTKLEKIGKGSFGEVF---------KGIDNRTQKVV--AIKIIDLEEAEDEIEDIQQEIT 84
Query: 67 FLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVCHA 126
LS PY+T YYG++ D L+I+MEY Q I+ ++
Sbjct: 85 VLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQIAT-ILREILKG 143
Query: 127 LEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFWM 186
L+YLH ++ IHRD+KAAN+LL++ GEV+LAD GV GQL + NTFVGTPFWM
Sbjct: 144 LDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKR-----NTFVGTPFWM 198
Query: 187 APEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRNMDIS 246
APE+IK +YD K DIWSLGIT +EL G+PP S L MK L IPK N ++ N
Sbjct: 199 APEVIKQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGNYS-K 257
Query: 247 PLGKDFIRSCLQQDPNQRPTCKQLLQHKW-LKKCSITNIMEEI 288
PL K+F+ +CL ++P+ RPT K+LL+HK+ L+ T+ + E+
Sbjct: 258 PL-KEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTEL 299
>7300224 [T] KOG0201 Serine/threonine protein kinase
Length = 642
Score = 209 bits (531), Expect = 1e-53
Identities = 116/272 (42%), Positives = 160/272 (58%), Gaps = 19/272 (6%)
Query: 7 FQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEIY 66
F E +GKG+FG+V+ + D + + V AIK I+LE + + ID + +EI
Sbjct: 13 FTKQERIGKGSFGEVF---------KGIDNRTQQVV--AIKIIDLEEAEDEIDDIQQEIM 61
Query: 67 FLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVCHA 126
LS PY+T YYG+F L+I+MEY E I+ +V
Sbjct: 62 VLSQCDSPYVTKYYGSFLKGTKLWIIMEYLGGGSALDLMKAGSFE-EMHIGIILREVLKG 120
Query: 127 LEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFWM 186
L+YLH +R +HRD+KAAN+LL++ G+V+LAD GV GQL +++ NTFVGTPFWM
Sbjct: 121 LDYLHSERKLHRDIKAANVLLSEQGDVKLADFGVAGQLTNTTSKR-----NTFVGTPFWM 175
Query: 187 APEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRNMDIS 246
APE+IK YD K DIWSLGIT +EL G+PP S L M+ L IPK N + + S
Sbjct: 176 APEVIKQSQYDAKADIWSLGITAIELAKGEPPNSELHPMRVLFLIPKNNPPQLTGSYTKS 235
Query: 247 PLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKK 278
KDF+ +CL +DP RPT K+LL++ ++KK
Sbjct: 236 --FKDFVEACLNKDPENRPTAKELLKYPFIKK 265
>At3g15220 [T] KOG0201 Serine/threonine protein kinase
Length = 690
Score = 208 bits (530), Expect = 1e-53
Identities = 117/302 (38%), Positives = 176/302 (57%), Gaps = 21/302 (6%)
Query: 6 QFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEI 65
+F +E +G+G+FGDVY A N+E +AIK I+LE S + I+ + KEI
Sbjct: 14 RFSQIELIGRGSFGDVYKAFDKDLNKE-----------VAIKVIDLEESEDEIEDIQKEI 62
Query: 66 YFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVCH 125
LS CPYIT YYG++ L+I+MEY + E + I + H
Sbjct: 63 SVLSQCRCPYITEYYGSYLHQTKLWIIMEYMAGGSVADLLQSNNPLDETSIACITRDLLH 122
Query: 126 ALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFW 185
A+EYLH + IHRD+KAANILL+++G+V++AD GV+ QL +R TFVGTPFW
Sbjct: 123 AVEYLHNEGKIHRDIKAANILLSENGDVKVADFGVSAQLTRTISRR-----KTFVGTPFW 177
Query: 186 MAPEIIKN-QSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRNMD 244
MAPE+I+N + Y+ K DIWSLGIT +E+ G+PP++ L M+ L IP+ + +
Sbjct: 178 MAPEVIQNSEGYNEKADIWSLGITVIEMAKGEPPLADLHPMRVLFIIPRETPPQL--DEH 235
Query: 245 ISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKKC-SITNIMEEITVMKTNQIL-SKEKP 302
S K+F+ CL++ P +RP+ K+L++H+++K ++E I Q+ +E P
Sbjct: 236 FSRQVKEFVSLCLKKAPAERPSAKELIKHRFIKNARKSPKLLERIRERPKYQVKEDEETP 295
Query: 303 RS 304
R+
Sbjct: 296 RN 297
>At1g53165 [T] KOG0201 Serine/threonine protein kinase
Length = 1007
Score = 208 bits (529), Expect = 2e-53
Identities = 120/307 (39%), Positives = 179/307 (58%), Gaps = 20/307 (6%)
Query: 6 QFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEI 65
+F E +G+G+FGDVY A D ++ K+V AIK I+LE S + I+ + KEI
Sbjct: 341 RFSQFELIGRGSFGDVYKAF---------DTELNKDV--AIKVIDLEESEDEIEDIQKEI 389
Query: 66 YFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVCH 125
LS CPYIT YYG++ L+I+MEY + E + I + H
Sbjct: 390 SVLSQCRCPYITEYYGSYLHQTKLWIIMEYMAGGSVADLLQPGNPLDEISIACITRDLLH 449
Query: 126 ALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFW 185
A+EYLH + IHRD+KAANILL+++G+V++AD GV+ QL +R TFVGTPFW
Sbjct: 450 AVEYLHAEGKIHRDIKAANILLSENGDVKVADFGVSAQLTRTISRR-----KTFVGTPFW 504
Query: 186 MAPEIIKN-QSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRNMD 244
MAPE+I+N + Y+ K DIWSLGIT +E+ G+PP++ L M+ L IP+ + + +
Sbjct: 505 MAPEVIQNSEGYNEKADIWSLGITMIEMAKGEPPLADLHPMRVLFIIPRESPPQLDEHFS 564
Query: 245 ISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKKC-SITNIMEEITVMKTNQILSKEKPR 303
PL K+F+ CL++ P +RP K+LL+H+++K ++E I Q+ E+
Sbjct: 565 -RPL-KEFVSFCLKKAPAERPNAKELLKHRFIKNARKSPKLLERIRERPKYQVKEDEEIP 622
Query: 304 SCKPRFP 310
+ P+ P
Sbjct: 623 TNGPKAP 629
>HsM5454174 [T] KOG0201 Serine/threonine protein kinase
Length = 426
Score = 204 bits (518), Expect = 3e-52
Identities = 114/272 (41%), Positives = 159/272 (57%), Gaps = 19/272 (6%)
Query: 7 FQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEIY 66
F L+ +GKG+FG+VY G + + +AIK I+LE + + I+ + +EI
Sbjct: 20 FTKLDRIGKGSFGEVYK----GIDNHTKEV-------VAIKIIDLEEAEDEIEDIQQEIT 68
Query: 67 FLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVCHA 126
LS PYIT Y+G++ L+I+MEY E I+ ++
Sbjct: 69 VLSQCDSPYITRYFGSYLKSTKLWIIMEYLGGGSALDLLKPGPLE-ETYIATILREILKG 127
Query: 127 LEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFWM 186
L+YLH +R IHRD+KAAN+LL++ G+V+LAD GV GQL + NTFVGTPFWM
Sbjct: 128 LDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKR-----NTFVGTPFWM 182
Query: 187 APEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRNMDIS 246
APE+IK +YD K DIWSLGIT +EL G+PP S L M+ L IPK N+ L
Sbjct: 183 APEVIKQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPK-NSPPTLEGQHSK 241
Query: 247 PLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKK 278
P K+F+ +CL +DP RPT K+LL+HK++ +
Sbjct: 242 PF-KEFVEACLNKDPRFRPTAKELLKHKFITR 272
>Hs21361358 [T] KOG0201 Serine/threonine protein kinase
Length = 426
Score = 204 bits (518), Expect = 3e-52
Identities = 114/272 (41%), Positives = 159/272 (57%), Gaps = 19/272 (6%)
Query: 7 FQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEIY 66
F L+ +GKG+FG+VY G + + +AIK I+LE + + I+ + +EI
Sbjct: 20 FTKLDRIGKGSFGEVYK----GIDNHTKEV-------VAIKIIDLEEAEDEIEDIQQEIT 68
Query: 67 FLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVCHA 126
LS PYIT Y+G++ L+I+MEY E I+ ++
Sbjct: 69 VLSQCDSPYITRYFGSYLKSTKLWIIMEYLGGGSALDLLKPGPLE-ETYIATILREILKG 127
Query: 127 LEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFWM 186
L+YLH +R IHRD+KAAN+LL++ G+V+LAD GV GQL + NTFVGTPFWM
Sbjct: 128 LDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKR-----NTFVGTPFWM 182
Query: 187 APEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRNMDIS 246
APE+IK +YD K DIWSLGIT +EL G+PP S L M+ L IPK N+ L
Sbjct: 183 APEVIKQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPK-NSPPTLEGQHSK 241
Query: 247 PLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKK 278
P K+F+ +CL +DP RPT K+LL+HK++ +
Sbjct: 242 PF-KEFVEACLNKDPRFRPTAKELLKHKFITR 272
>Hs15011880 [T] KOG0201 Serine/threonine protein kinase
Length = 416
Score = 201 bits (511), Expect = 2e-51
Identities = 112/274 (40%), Positives = 163/274 (58%), Gaps = 19/274 (6%)
Query: 7 FQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEIY 66
F LE +GKG+FG+V+ + D + + V AIK I+LE + + I+ + +EI
Sbjct: 24 FTKLERIGKGSFGEVF---------KGIDNRTQQVV--AIKIIDLEEAEDEIEDIQQEIT 72
Query: 67 FLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVCHA 126
LS Y+T YYG++ L+I+MEY Q ++ ++
Sbjct: 73 VLSQCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQIAT-MLKEILKG 131
Query: 127 LEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFWM 186
L+YLH ++ IHRD+KAAN+LL++ G+V+LAD GV GQL + NTFVGTPFWM
Sbjct: 132 LDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKR-----NTFVGTPFWM 186
Query: 187 APEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRNMDIS 246
APE+I+ +YD K DIWSLGIT +EL G+PP S + M+ L IPK N +++ D +
Sbjct: 187 APEVIQQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTLVG--DFT 244
Query: 247 PLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKKCS 280
K+FI +CL +DP+ RPT K+LL+HK++ K S
Sbjct: 245 KSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNS 278
>CE28674 [T] KOG0201 Serine/threonine protein kinase
Length = 651
Score = 199 bits (505), Expect = 1e-50
Identities = 112/282 (39%), Positives = 162/282 (56%), Gaps = 18/282 (6%)
Query: 7 FQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEIY 66
F E +G+G+FG+VY + D + + V AIK I+LE + + I+ + +EI
Sbjct: 32 FTKQERIGRGSFGEVY---------KGIDNRTGRVV--AIKIIDLEQAEDEIEDIQQEIQ 80
Query: 67 FLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVCHA 126
LS Y+T Y+G+F L+I+MEY E I+ ++
Sbjct: 81 VLSQCDSQYVTKYFGSFLKGSKLWIIMEYLGGGSALDLTKSGKLD-ESHIAVILREILKG 139
Query: 127 LEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFWM 186
LEYLH +R IHRD+KAAN+L+++ G+V++AD GV GQL K TFVG+PFWM
Sbjct: 140 LEYLHSERKIHRDIKAANVLVSEHGDVKVADFGVAGQLTETV-----KKRITFVGSPFWM 194
Query: 187 APEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRNMDIS 246
APE+IK SYD K DIWSLGIT +EL NG+PP S L M+ L IPK N +L+ S
Sbjct: 195 APELIKQSSYDYKADIWSLGITAIELANGEPPHSDLHPMRVLFLIPK-NPPPVLQGSQWS 253
Query: 247 PLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKKCSITNIMEEI 288
K+F+ CL +DP RP+ LL+H+++K+ +I+ ++
Sbjct: 254 KPFKEFVEMCLNKDPENRPSASTLLKHQFIKRAKKNSILVDL 295
>CE07510 [T] KOG0201 Serine/threonine protein kinase
Length = 653
Score = 199 bits (505), Expect = 1e-50
Identities = 112/282 (39%), Positives = 162/282 (56%), Gaps = 18/282 (6%)
Query: 7 FQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEIY 66
F E +G+G+FG+VY + D + + V AIK I+LE + + I+ + +EI
Sbjct: 34 FTKQERIGRGSFGEVY---------KGIDNRTGRVV--AIKIIDLEQAEDEIEDIQQEIQ 82
Query: 67 FLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVCHA 126
LS Y+T Y+G+F L+I+MEY E I+ ++
Sbjct: 83 VLSQCDSQYVTKYFGSFLKGSKLWIIMEYLGGGSALDLTKSGKLD-ESHIAVILREILKG 141
Query: 127 LEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFWM 186
LEYLH +R IHRD+KAAN+L+++ G+V++AD GV GQL K TFVG+PFWM
Sbjct: 142 LEYLHSERKIHRDIKAANVLVSEHGDVKVADFGVAGQLTETV-----KKRITFVGSPFWM 196
Query: 187 APEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRNMDIS 246
APE+IK SYD K DIWSLGIT +EL NG+PP S L M+ L IPK N +L+ S
Sbjct: 197 APELIKQSSYDYKADIWSLGITAIELANGEPPHSDLHPMRVLFLIPK-NPPPVLQGSQWS 255
Query: 247 PLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKKCSITNIMEEI 288
K+F+ CL +DP RP+ LL+H+++K+ +I+ ++
Sbjct: 256 KPFKEFVEMCLNKDPENRPSASTLLKHQFIKRAKKNSILVDL 297
>SPAC2C4.14c [T] KOG0201 Serine/threonine protein kinase
Length = 312
Score = 196 bits (498), Expect = 7e-50
Identities = 115/301 (38%), Positives = 174/301 (57%), Gaps = 21/301 (6%)
Query: 6 QFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEI 65
Q++ L+ +G+G+FG V+ A Q+ KI +A+K ++L+ + + I+ L +EI
Sbjct: 5 QYRDLQLIGQGSFGSVFRA------QDVESSKI-----VALKVVDLDATKDQIETLTQEI 53
Query: 66 YFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVCH 125
FL L+ +IT YY +F L+I MEYC +E+ ++ QV
Sbjct: 54 NFLIDLNSVHITKYYASFVDGFRLWITMEYCDGGSCLDLLKLSGTFSERVIAEVMRQVLE 113
Query: 126 ALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFW 185
AL YLH + +HRD+KAANIL DG V+LAD GV+GQL+ ++ + FVGTPFW
Sbjct: 114 ALVYLHGQGKMHRDIKAANILTMKDGLVKLADFGVSGQLESLRDKN-----DDFVGTPFW 168
Query: 186 MAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRNMDI 245
MAPE++K Y+ K DIWSLGIT EL G+PP S + MK L+ IPK + S+ R+
Sbjct: 169 MAPEVVKQTGYNYKADIWSLGITAYELATGEPPYSGIHPMKVLLLIPKHSPPSLERS-KF 227
Query: 246 SPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKK-CSITNIMEEI---TVMKTNQILSKEK 301
S DF+ +CL+++P R T + L +HK++KK C T++ E + K +++L +
Sbjct: 228 SRAFCDFVSNCLKKNPKDRATAEYLSKHKFIKKYCPNTSVKEVVASYAKWKESELLPEAT 287
Query: 302 P 302
P
Sbjct: 288 P 288
>Hs5454094 [T] KOG0574 STE20-like serine/threonine kinase MST
Length = 491
Score = 182 bits (461), Expect = 1e-45
Identities = 106/284 (37%), Positives = 153/284 (53%), Gaps = 22/284 (7%)
Query: 7 FQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEIY 66
F +LE +G+G++G V+ A + S Q +AIK + +E + I +KEI
Sbjct: 27 FDVLEKLGEGSYGSVFKAIHKESGQV-----------VAIKQVPVESDLQEI---IKEIS 72
Query: 67 FLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXT-EQTTCFIILQVCH 125
+ PY+ YYG++ + +L+IVMEYC E I+
Sbjct: 73 IMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLK 132
Query: 126 ALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFW 185
LEYLH R IHRD+KA NILLN +G +LAD GV GQL + NT +GTPFW
Sbjct: 133 GLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKR-----NTVIGTPFW 187
Query: 186 MAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRNMDI 245
MAPE+I+ Y+ DIWSLGIT++E+ GKPP + + M+A+ IP N R ++
Sbjct: 188 MAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIP-TNPPPTFRKPEL 246
Query: 246 -SPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKKCSITNIMEEI 288
S DF++ CL ++P QR T QLLQH ++K +I+ ++
Sbjct: 247 WSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAKPVSILRDL 290
>Hs16178962 [T] KOG0574 STE20-like serine/threonine kinase MST
Length = 491
Score = 182 bits (461), Expect = 1e-45
Identities = 106/284 (37%), Positives = 153/284 (53%), Gaps = 22/284 (7%)
Query: 7 FQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEIY 66
F +LE +G+G++G V+ A + S Q +AIK + +E + I +KEI
Sbjct: 27 FDVLEKLGEGSYGSVFKAIHKESGQV-----------VAIKQVPVESDLQEI---IKEIS 72
Query: 67 FLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXT-EQTTCFIILQVCH 125
+ PY+ YYG++ + +L+IVMEYC E I+
Sbjct: 73 IMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLK 132
Query: 126 ALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFW 185
LEYLH R IHRD+KA NILLN +G +LAD GV GQL + NT +GTPFW
Sbjct: 133 GLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKR-----NTVIGTPFW 187
Query: 186 MAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRNMDI 245
MAPE+I+ Y+ DIWSLGIT++E+ GKPP + + M+A+ IP N R ++
Sbjct: 188 MAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIP-TNPPPTFRKPEL 246
Query: 246 -SPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKKCSITNIMEEI 288
S DF++ CL ++P QR T QLLQH ++K +I+ ++
Sbjct: 247 WSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAKPVSILRDL 290
>Hs5454096 [T] KOG0574 STE20-like serine/threonine kinase MST
Length = 487
Score = 180 bits (456), Expect = 5e-45
Identities = 105/284 (36%), Positives = 152/284 (52%), Gaps = 22/284 (7%)
Query: 7 FQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEIY 66
F +LE +G+G++G VY A + + Q +AIK + +E + I +KEI
Sbjct: 30 FDVLEKLGEGSYGSVYKAIHKETGQI-----------VAIKQVPVESDLQEI---IKEIS 75
Query: 67 FLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXX-TEQTTCFIILQVCH 125
+ P++ YYG++ + +L+IVMEYC TE I+
Sbjct: 76 IMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLK 135
Query: 126 ALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFW 185
LEYLH R IHRD+KA NILLN +G +LAD GV GQL + NT +GTPFW
Sbjct: 136 GLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKR-----NTVIGTPFW 190
Query: 186 MAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRNMDI 245
MAPE+I+ Y+ DIWSLGIT +E+ GKPP + + M+A+ IP N R ++
Sbjct: 191 MAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIP-TNPPPTFRKPEL 249
Query: 246 -SPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKKCSITNIMEEI 288
S DF++ CL + P QR T QLLQH +++ +I+ ++
Sbjct: 250 WSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRDL 293
>CE27965 [T] KOG0574 STE20-like serine/threonine kinase MST
Length = 525
Score = 176 bits (447), Expect = 5e-44
Identities = 99/281 (35%), Positives = 146/281 (51%), Gaps = 20/281 (7%)
Query: 7 FQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEIY 66
F ++ +G+G++G V+ A + S K+P + L ++KEI
Sbjct: 63 FDIVGKLGEGSYGSVHKAIHRESGHVLAIKKVPVDTDL--------------QEIIKEIS 108
Query: 67 FLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXX-XTEQTTCFIILQVCH 125
+ Y+ YYG++ +L+IVMEYC +EQ ++
Sbjct: 109 IMQQCKSKYVVKYYGSYFKHSDLWIVMEYCGAGSISDIMRARRKPLSEQEISAVLRDTLK 168
Query: 126 ALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFW 185
L+YLH+ + IHRD+KA NILLN DG +LAD GV GQL + NT +GTPFW
Sbjct: 169 GLQYLHDLKKIHRDIKAGNILLNTDGIAKLADFGVAGQLTDTMAKR-----NTVIGTPFW 223
Query: 186 MAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRNMDI 245
MAPE+I+ YD K DIWSLGIT +E+ G+PP S + M+A+ IP + + +
Sbjct: 224 MAPEVIEEIGYDTKADIWSLGITAIEMAEGRPPYSDIHPMRAIFMIPTKPPPTFKKPEEW 283
Query: 246 SPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKKCSITNIME 286
S DFIRSCL + P +R T +L +H ++K +IM+
Sbjct: 284 SSEFNDFIRSCLIKKPEERKTALRLCEHTFIKNAPGCDIMQ 324
>CE27726 [T] KOG0574 STE20-like serine/threonine kinase MST
Length = 640
Score = 176 bits (447), Expect = 5e-44
Identities = 99/281 (35%), Positives = 146/281 (51%), Gaps = 20/281 (7%)
Query: 7 FQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEIY 66
F ++ +G+G++G V+ A + S K+P + L ++KEI
Sbjct: 35 FDIVGKLGEGSYGSVHKAIHRESGHVLAIKKVPVDTDL--------------QEIIKEIS 80
Query: 67 FLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXX-XTEQTTCFIILQVCH 125
+ Y+ YYG++ +L+IVMEYC +EQ ++
Sbjct: 81 IMQQCKSKYVVKYYGSYFKHSDLWIVMEYCGAGSISDIMRARRKPLSEQEISAVLRDTLK 140
Query: 126 ALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFW 185
L+YLH+ + IHRD+KA NILLN DG +LAD GV GQL + NT +GTPFW
Sbjct: 141 GLQYLHDLKKIHRDIKAGNILLNTDGIAKLADFGVAGQLTDTMAKR-----NTVIGTPFW 195
Query: 186 MAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRNMDI 245
MAPE+I+ YD K DIWSLGIT +E+ G+PP S + M+A+ IP + + +
Sbjct: 196 MAPEVIEEIGYDTKADIWSLGITAIEMAEGRPPYSDIHPMRAIFMIPTKPPPTFKKPEEW 255
Query: 246 SPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKKCSITNIME 286
S DFIRSCL + P +R T +L +H ++K +IM+
Sbjct: 256 SSEFNDFIRSCLIKKPEERKTALRLCEHTFIKNAPGCDIMQ 296
>CE27082 [T] KOG0574 STE20-like serine/threonine kinase MST
Length = 421
Score = 176 bits (447), Expect = 5e-44
Identities = 99/281 (35%), Positives = 146/281 (51%), Gaps = 20/281 (7%)
Query: 7 FQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEIY 66
F ++ +G+G++G V+ A + S K+P + L ++KEI
Sbjct: 35 FDIVGKLGEGSYGSVHKAIHRESGHVLAIKKVPVDTDL--------------QEIIKEIS 80
Query: 67 FLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXX-XTEQTTCFIILQVCH 125
+ Y+ YYG++ +L+IVMEYC +EQ ++
Sbjct: 81 IMQQCKSKYVVKYYGSYFKHSDLWIVMEYCGAGSISDIMRARRKPLSEQEISAVLRDTLK 140
Query: 126 ALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFW 185
L+YLH+ + IHRD+KA NILLN DG +LAD GV GQL + NT +GTPFW
Sbjct: 141 GLQYLHDLKKIHRDIKAGNILLNTDGIAKLADFGVAGQLTDTMAKR-----NTVIGTPFW 195
Query: 186 MAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRNMDI 245
MAPE+I+ YD K DIWSLGIT +E+ G+PP S + M+A+ IP + + +
Sbjct: 196 MAPEVIEEIGYDTKADIWSLGITAIEMAEGRPPYSDIHPMRAIFMIPTKPPPTFKKPEEW 255
Query: 246 SPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKKCSITNIME 286
S DFIRSCL + P +R T +L +H ++K +IM+
Sbjct: 256 SSEFNDFIRSCLIKKPEERKTALRLCEHTFIKNAPGCDIMQ 296
>CE07064 [T] KOG0574 STE20-like serine/threonine kinase MST
Length = 523
Score = 176 bits (447), Expect = 5e-44
Identities = 99/281 (35%), Positives = 146/281 (51%), Gaps = 20/281 (7%)
Query: 7 FQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEIY 66
F ++ +G+G++G V+ A + S K+P + L ++KEI
Sbjct: 63 FDIVGKLGEGSYGSVHKAIHRESGHVLAIKKVPVDTDL--------------QEIIKEIS 108
Query: 67 FLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXX-XTEQTTCFIILQVCH 125
+ Y+ YYG++ +L+IVMEYC +EQ ++
Sbjct: 109 IMQQCKSKYVVKYYGSYFKHSDLWIVMEYCGAGSISDIMRARRKPLSEQEISAVLRDTLK 168
Query: 126 ALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFW 185
L+YLH+ + IHRD+KA NILLN DG +LAD GV GQL + NT +GTPFW
Sbjct: 169 GLQYLHDLKKIHRDIKAGNILLNTDGIAKLADFGVAGQLTDTMAKR-----NTVIGTPFW 223
Query: 186 MAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRNMDI 245
MAPE+I+ YD K DIWSLGIT +E+ G+PP S + M+A+ IP + + +
Sbjct: 224 MAPEVIEEIGYDTKADIWSLGITAIEMAEGRPPYSDIHPMRAIFMIPTKPPPTFKKPEEW 283
Query: 246 SPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKKCSITNIME 286
S DFIRSCL + P +R T +L +H ++K +IM+
Sbjct: 284 SSEFNDFIRSCLIKKPEERKTALRLCEHTFIKNAPGCDIMQ 324
>SPAC9G1.09 [T] KOG0201 Serine/threonine protein kinase
Length = 471
Score = 176 bits (446), Expect = 7e-44
Identities = 113/335 (33%), Positives = 168/335 (49%), Gaps = 27/335 (8%)
Query: 2 LSLQQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLL 61
L+ + LL +G G+FG V+ A +E I +AIK I+LE + I +
Sbjct: 4 LNANSYTLLRKLGSGSFGVVWKA------RENVSGDI-----IAIKQIDLETGIDDITDI 52
Query: 62 LKEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIIL 121
+E++ LS + + YYG F L+I+ME+ EQ I+
Sbjct: 53 EQEVFMLSNCNSSNVIQYYGCFVDGYTLWILMEHMDGGSVSGLLKMGRL-NEQVISIILR 111
Query: 122 QVCHALEYLHEKRLIHRDLKAANILLNDD-GEVRLADLGVTGQLKFNSTRHGGKNLNTFV 180
+V + L YLH + IHRD+KAANILL+ G V+LAD GV QL ++R +TFV
Sbjct: 112 EVLYGLNYLHGQNKIHRDIKAANILLSSSTGNVKLADFGVAAQLSNAASRR-----HTFV 166
Query: 181 GTPFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSIL 240
GTPFWMAPE+I+ SY DIWSLGIT +E+ NG PP + + M+ + IP+ +
Sbjct: 167 GTPFWMAPEVIQQTSYGLAADIWSLGITAIEMANGIPPRATMHPMRVIFEIPQSEPPKL- 225
Query: 241 RNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKKCSITNIMEEITVMKTNQILSKE 300
+ SP +DF+ CL +PN R + K+LLQH ++K + + V K N++
Sbjct: 226 -DDHFSPTFRDFVSCCLDLNPNMRWSAKELLQHPFIKSAGTVKDIIPLLVQKENKLFDDS 284
Query: 301 KPRSCKPRF-----PLSDKVYKTNLPNQLESWRFE 330
+ P + + + N +E W FE
Sbjct: 285 DQSVLEETINNTLKPFEEPIAEGNA--DIEDWTFE 317
>7302458 [T] KOG0574 STE20-like serine/threonine kinase MST
Length = 596
Score = 174 bits (442), Expect = 2e-43
Identities = 101/281 (35%), Positives = 146/281 (51%), Gaps = 20/281 (7%)
Query: 7 FQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEIY 66
F ++ +G+G++G VY A + S+ +AIK + +E I +KEI
Sbjct: 42 FDIMYKLGEGSYGSVYKAVHKESSSI-----------VAIKLVPVESDLHEI---IKEIS 87
Query: 67 FLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXX-TEQTTCFIILQVCH 125
+ PY+ YYG++ +L+I MEYC TE I+
Sbjct: 88 IMQQCDSPYVVRYYGSYFKQYDLWICMEYCGAGSVSDIMRLRKKTLTEDEIATILSDTLQ 147
Query: 126 ALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFW 185
L YLH +R IHRD+KAANILLN +G +LAD GV GQL + NT +GTPFW
Sbjct: 148 GLVYLHLRRKIHRDIKAANILLNTEGYAKLADFGVAGQLTDTMAKR-----NTVIGTPFW 202
Query: 186 MAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRNMDI 245
MAPE+I+ YD DIWSLGIT LE+ GKPP + M+A+ IP+ S
Sbjct: 203 MAPEVIEEIGYDCVADIWSLGITALEMAEGKPPYGEIHPMRAIFMIPQKPPPSFREPDRW 262
Query: 246 SPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKKCSITNIME 286
S DF+ CL ++P+ R T +LL+H++++ +I++
Sbjct: 263 STEFIDFVSKCLVKEPDDRATATELLEHEFIRNAKHRSILK 303
>At1g69220 [T] KOG0576 Mitogen-activated protein kinase kinase kinase kinase
(MAP4K) germinal center kinase family
Length = 836
Score = 174 bits (441), Expect = 3e-43
Identities = 99/292 (33%), Positives = 151/292 (50%), Gaps = 17/292 (5%)
Query: 6 QFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEI 65
+++ L +GKG++G VY A L +++ +A+K I+L E + + EI
Sbjct: 248 KYEFLNELGKGSYGSVYKARDLKTSEI-----------VAVKVISLTEGEEGYEEIRGEI 296
Query: 66 YFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQ-TTCFIILQVC 124
L + P + Y G++ G+ L+IVMEYC E+ +I +
Sbjct: 297 EMLQQCNHPNVVRYLGSYQGEDYLWIVMEYCGGGSVADLMNVTEEALEEYQIAYICREAL 356
Query: 125 HALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPF 184
L YLH +HRD+K NILL + GEV+L D GV QL TR K NTF+GTP
Sbjct: 357 KGLAYLHSIYKVHRDIKGGNILLTEQGEVKLGDFGVAAQL----TRTMSKR-NTFIGTPH 411
Query: 185 WMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRNMD 244
WMAPE+I+ YDGK D+W+LG++ +E+ G PP S + M+ L I A +
Sbjct: 412 WMAPEVIQENRYDGKVDVWALGVSAIEMAEGLPPRSSVHPMRVLFMISIEPAPMLEDKEK 471
Query: 245 ISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKKCSITNIMEEITVMKTNQI 296
S + DF+ CL ++P RPT ++L+HK++++C + K+ QI
Sbjct: 472 WSLVFHDFVAKCLTKEPRLRPTAAEMLKHKFVERCKTGASAMSPKIEKSRQI 523
>Hs4826878 [T] KOG0582 Ste20-like serine/threonine protein kinase
Length = 527
Score = 169 bits (427), Expect = 1e-41
Identities = 111/316 (35%), Positives = 153/316 (48%), Gaps = 27/316 (8%)
Query: 2 LSLQQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLL 61
++ ++L E +G G V A+ PK +AIK INLE +D L
Sbjct: 12 INRDDYELQEVIGSGATAVVQAAYCA-----------PKKEKVAIKRINLEKCQTSMDEL 60
Query: 62 LKEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXX--------XXXXXXXXXXTE 113
LKEI +S H P I YY +F L++VM+ S E
Sbjct: 61 LKEIQAMSQCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDE 120
Query: 114 QTTCFIILQVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGG 173
T I+ +V LEYLH+ IHRD+KA NILL +DG V++AD GV+ L
Sbjct: 121 STIATILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRN 180
Query: 174 KNLNTFVGTPFWMAPEIIKN-QSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIP 232
K TFVGTP WMAPE+++ + YD K DIWS GIT +EL G P MK LM
Sbjct: 181 KVRKTFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTL 240
Query: 233 KLNADSILRNMD----ISPLGKDF---IRSCLQQDPNQRPTCKQLLQHKWLKKCSITNIM 285
+ + S+ + + GK F I CLQ+DP +RPT +LL+HK+ +K +
Sbjct: 241 QNDPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQKAKNKEFL 300
Query: 286 EEITVMKTNQILSKEK 301
+E T+ + I + K
Sbjct: 301 QEKTLQRAPTISERAK 316
>YHR102w [T] KOG0201 Serine/threonine protein kinase
Length = 1080
Score = 164 bits (415), Expect = 3e-40
Identities = 98/286 (34%), Positives = 162/286 (56%), Gaps = 22/286 (7%)
Query: 7 FQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEIY 66
F+ E +G+G FG VY + + + + AIK +NL+ ++ ++ + +EI
Sbjct: 23 FKRTEVIGRGKFGVVYKGYNVKTGRV-----------YAIKVLNLDSDSDEVEDVQREIQ 71
Query: 67 FLSTL-HCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVCH 125
FL++L IT YYG++ D +L+I+ME+C+ E+ I+ ++
Sbjct: 72 FLASLKQISNITRYYGSYLKDTSLWIIMEHCAGGSLRSLLRPGKID-EKYIGVIMRELLV 130
Query: 126 ALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFW 185
AL+ +H+ +IHRD+KAAN+L+ ++G V+L D GV Q+ S R T GTP+W
Sbjct: 131 ALKCIHKDNVIHRDIKAANVLITNEGNVKLCDFGVAAQVNQTSLRR-----QTMAGTPYW 185
Query: 186 MAPEII-KNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRNMD 244
MAPE+I + YD K DIWSLGITT E+ G PP +++++A+ I K + L +
Sbjct: 186 MAPEVIMEGVYYDTKVDIWSLGITTYEIATGNPPYCDVEALRAMQLIIK-SKPPRLEDRS 244
Query: 245 ISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLK--KCSITNIMEEI 288
S K+FI CL +DP +R + LL+ K+++ K + T+I++E+
Sbjct: 245 YSTSLKEFIALCLDEDPKERLSADDLLKSKFIRAHKATPTSILKEL 290
>7302511 [T] KOG0576 Mitogen-activated protein kinase kinase kinase kinase
(MAP4K) germinal center kinase family
Length = 1218
Score = 163 bits (412), Expect = 6e-40
Identities = 97/277 (35%), Positives = 149/277 (53%), Gaps = 22/277 (7%)
Query: 6 QFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEI 65
+++L++ +G G +GDVY A + SN+ AIK I LE S++ I ++ +EI
Sbjct: 25 EYELIQKIGSGTYGDVYKAKRIQSNELA-----------AIKVIKLEPSDD-IQIIQQEI 72
Query: 66 YFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVCH 125
+ P I YYG++ L+I ME+C TE ++ +
Sbjct: 73 IMMRDCRHPNIIAYYGSYLRRDKLWICMEFCGGGSLQDIYQVTGPLTEVQIAYMCRETLK 132
Query: 126 ALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFW 185
LEYLH +HRD+K ANILL + G+V+LAD GV+ Q+ + +F+GTP+W
Sbjct: 133 GLEYLHSMGKMHRDIKGANILLTEYGDVKLADFGVSAQITATINKR-----KSFIGTPYW 187
Query: 186 MAPEII---KNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLN-ADSILR 241
MAPE+ + Y+ CDIW+ GIT +EL +PPM L M+AL + K L
Sbjct: 188 MAPEVAAVERKGGYNQLCDIWACGITAIELAELQPPMFDLHPMRALFLMSKSGFKPPTLN 247
Query: 242 NMD-ISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLK 277
N D SP +FI++ L ++P +RPT ++LLQH +++
Sbjct: 248 NKDKWSPTFHNFIKTALTKNPKKRPTAERLLQHPFVQ 284
>At4g14480 [T] KOG0582 Ste20-like serine/threonine protein kinase
Length = 487
Score = 161 bits (408), Expect = 2e-39
Identities = 105/361 (29%), Positives = 176/361 (48%), Gaps = 41/361 (11%)
Query: 2 LSLQQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLL 61
L + ++++ +G G VY A + N ++ +AIK I+L+ S D L
Sbjct: 10 LDAEAYEIICKIGVGVSASVYKAICIPMN----------SMVVAIKAIDLDQSRADFDSL 59
Query: 62 LKEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEY--CSXXXXXXXXXXXXXXTEQTTCFI 119
+E +S L P I + Y +FT D L++VM + C E
Sbjct: 60 RRETKTMSLLSHPNILNAYCSFTVDRCLWVVMPFMSCGSLHSIVSSSFPSGLPENCISVF 119
Query: 120 ILQVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQL-----KFNSTRHGGK 174
+ + +A+ YLH++ +HRD+KA NIL++ DG V+LAD GV+ + + T
Sbjct: 120 LKETLNAISYLHDQGHLHRDIKAGNILVDSDGSVKLADFGVSASIYEPVTSSSGTTSSSL 179
Query: 175 NLNTFVGTPFWMAPEIIKNQS-YDGKCDIWSLGITTLELLNGKPPMSHLDSMKA-LMRIP 232
L GTP+WMAPE++ + + Y K DIWS GIT LEL +G+PP+SHL +K+ LM+I
Sbjct: 180 RLTDIAGTPYWMAPEVVHSHTGYGFKADIWSFGITALELAHGRPPLSHLPPLKSLLMKIT 239
Query: 233 K----------LNADSILRNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKKCS-- 280
K + S N S ++ + CL+QDP +RP+ ++LL+H + K C
Sbjct: 240 KRFHFSDYEINTSGSSKKGNKKFSKAFREMVGLCLEQDPTKRPSAEKLLKHPFFKNCKGL 299
Query: 281 ---ITNIMEEIT----VMKTNQILSKEKPRSCKPRFPLSDKVYKTNLPNQLESWRFEDES 333
+ N++ ++ + +QIL K + +++ K ++ W F ++
Sbjct: 300 DFVVKNVLHSLSNAEQMFMESQILIKSVGDDDEEEEEEDEEIVKN---RRISGWNFREDD 356
Query: 334 V 334
+
Sbjct: 357 L 357
>At4g24100 [T] KOG0582 Ste20-like serine/threonine protein kinase
Length = 710
Score = 159 bits (402), Expect = 9e-39
Identities = 98/285 (34%), Positives = 148/285 (51%), Gaps = 25/285 (8%)
Query: 5 QQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKE 64
+ ++L+E +G G VY A YL P N +AIKC++L+ N +D + +E
Sbjct: 31 KDYKLMEEIGHGASAVVYRAIYL-----------PTNEVVAIKCLDLDRCNSNLDDIRRE 79
Query: 65 IYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXX--XXXXXXXXXXXTEQTTCFIILQ 122
+S + P + + +F+ D +L++VM + + E C ++ +
Sbjct: 80 SQTMSLIDHPNVIKSFCSFSVDHSLWVVMPFMAQGSCLHLMKTAYSDGFEESAICCVLKE 139
Query: 123 VCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGT 182
AL+YLH + IHRD+KA NILL+D+GE++L D GV+ L N R + NTFVGT
Sbjct: 140 TLKALDYLHRQGHIHRDVKAGNILLDDNGEIKLGDFGVSACLFDNGDRQRAR--NTFVGT 197
Query: 183 PFWMAPEIIK-NQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRI-----PKLNA 236
P WMAPE+++ Y+ K DIWS GIT LEL +G P S MK L+ P L+
Sbjct: 198 PCWMAPEVLQPGNGYNSKADIWSFGITALELAHGHAPFSKYPPMKVLLMTIQNAPPGLDY 257
Query: 237 DS----ILRNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLK 277
D R + K+ + CL +D +RPT ++LL+H K
Sbjct: 258 DRDKKFSKRTFSCAQSFKEMVAMCLVKDQTKRPTAEKLLKHSCFK 302
>CE26212 [T] KOG0582 Ste20-like serine/threonine protein kinase
Length = 545
Score = 158 bits (399), Expect = 2e-38
Identities = 107/296 (36%), Positives = 146/296 (49%), Gaps = 39/296 (13%)
Query: 7 FQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEIY 66
++L E +G G V+ A+ L P+N +AIKCINLE +D L EI
Sbjct: 57 YKLDESIGVGATATVFTAYCL-----------PRNEKVAIKCINLEKCQTSVDELSHEIQ 105
Query: 67 FLSTLHCPYITHYYGTFTGDCNLYIVMEY--CSXXXXXXXXXXXXXXTEQ---------T 115
+S + P + YY +F L++VM C EQ +
Sbjct: 106 AMSQCNHPNVVSYYTSFIAQEELWVVMRLLNCGSMLDILKRKVKAIGKEQAQFGVLDEVS 165
Query: 116 TCFIILQVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGG-- 173
++ +V LEY H IHRD+KA NILL DDG +++AD GV+G L GG
Sbjct: 166 IATVLREVLKGLEYFHLNGQIHRDIKAGNILLADDGTIQIADFGVSGWL----ASSGGDL 221
Query: 174 ---KNLNTFVGTPFWMAPEIIKN-QSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALM 229
K +TFVGTP WMAPE+++ Q YD K DIWSLGI +EL G P MK LM
Sbjct: 222 SRQKVRHTFVGTPCWMAPEVMEQVQGYDFKADIWSLGILAIELATGTAPYHKYPPMKVLM 281
Query: 230 RIPKLNADSILRNMD----ISPLGKDF---IRSCLQQDPNQRPTCKQLLQHKWLKK 278
+ + ++ N + GK F IR CLQ+DP +RPT +LL++ + KK
Sbjct: 282 LTLQNDPPTLETNAERKDQYKAYGKSFKTLIRDCLQKDPAKRPTASELLKYSFFKK 337
>SPBC17F3.02 [T] KOG0201 Serine/threonine protein kinase
Length = 652
Score = 156 bits (395), Expect = 6e-38
Identities = 101/292 (34%), Positives = 153/292 (51%), Gaps = 33/292 (11%)
Query: 10 LECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEIYFLS 69
LE VG+G++G VY + + +AIK +NL+ + + + KE+ LS
Sbjct: 13 LELVGRGSYGAVYRGICNLTKET-----------VAIKILNLDTDEDEVSDIQKEVAVLS 61
Query: 70 TLH---CPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVCHA 126
L I Y+G++ NL+I+M+YC +E I+ + A
Sbjct: 62 ELKQSDVENIIKYHGSYLVGTNLWIIMDYCHGGSVRTLMEAGPI-SEPCISLILRETLQA 120
Query: 127 LEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFWM 186
L+++H +IHRD+KAANIL++ G V+L D GV +L N + TF+GTP+WM
Sbjct: 121 LKFIHHAGIIHRDIKAANILVSMSGNVKLCDFGVAAELNINRRKR-----ITFIGTPYWM 175
Query: 187 APEIIKN-QSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRI-----PKLNADSIL 240
APE+I++ Q Y+ DIWSLGIT E+ G PP + D +A+ I P+LN
Sbjct: 176 APEVIRDGQEYNVMADIWSLGITAYEIATGSPPHAKEDPFRAVYLIAHTAPPRLNG---- 231
Query: 241 RNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKKCSITNIMEEITVMK 292
+ S L K+FI SCLQ P +R +LL+ K++K+ S +I E V+K
Sbjct: 232 ---NFSALLKEFIASCLQDVPQRRLDSSELLKSKFIKQYSRMSISELTNVVK 280
>SPBC21.06c [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 1062
Score = 156 bits (394), Expect = 7e-38
Identities = 121/441 (27%), Positives = 190/441 (42%), Gaps = 51/441 (11%)
Query: 11 ECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHS-NEPIDLLLKEIYFLS 69
+C+GKG FG VY G N I +A+K + L + ++ EI L
Sbjct: 13 DCLGKGAFGAVYR----GLN-------IKNGETVAVKKVKLSKMLKSDLSVIKMEIDLLK 61
Query: 70 TLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVCHALEY 129
L P I Y G++ + +L I++EYC E QV L Y
Sbjct: 62 NLDHPNIVKYRGSYQTNDSLCIILEYCENGSLRSICKNFGKIPENLVALYTFQVLQGLLY 121
Query: 130 LHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFWMAPE 189
LH + +IHRD+K ANIL DG ++LAD GV +T+ ++ VG+P+WMAPE
Sbjct: 122 LHNQGVIHRDIKGANILTTKDGTIKLADFGV-------ATKINALEDHSVVGSPYWMAPE 174
Query: 190 IIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRNMDISPLG 249
+I+ DIWS+G T +ELL+G PP LD AL R+ K + N IS
Sbjct: 175 VIELVGATTASDIWSVGCTVIELLDGNPPYYDLDPTSALFRMVKDEHPPLPSN--ISSAA 232
Query: 250 KDFIRSCLQQDPNQRPTCKQLLQHKW-----------------------LKKCSITNIME 286
K F+ C Q+DPN R ++LL+H W +K+ ++T I+E
Sbjct: 233 KSFLMQCFQKDPNLRIKTRKLLKHPWVIMNQTSSKFSDAIDEVQKYNERVKESTLTAIIE 292
Query: 287 EITVMKTNQILSKEKPRSC----KPRFPLSDKVYKTNLPNQLE-SWRFEDESVLRFDGLG 341
T + N L + S P+ P+++ N N+ + + + D+ + + +
Sbjct: 293 P-TSNRINPTLHSGRQSSYHMPESPKTPIAESPDHDNWDNEFQGTLKISDDVLKKSEHFM 351
Query: 342 DIPNLYXXXXXXXXXXXSPLLTKQQLRTPNISTPTS-ALSPTSMAISPKTNLSTPATESY 400
D + + SP ++ + IS + SP S + + + S PA
Sbjct: 352 DFCSNFKGKNNSSSITSSPSKSRHAFNSDQISESNNFNASPLSTPLKAQFDPSKPALNRS 411
Query: 401 EDVSSSPSEQKMKLGHENQNI 421
D +P ++ +NI
Sbjct: 412 IDHQKTPQHKRYLSTEFKENI 432
>Hs19923464 [T] KOG0577 Serine/threonine protein kinase
Length = 898
Score = 155 bits (393), Expect = 1e-37
Identities = 96/271 (35%), Positives = 140/271 (51%), Gaps = 26/271 (9%)
Query: 13 VGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINL--EHSNEPIDLLLKEIYFLST 70
+G G+FG VY A +N+ +AIK ++ + ++E +LKE+ FL
Sbjct: 30 IGHGSFGAVYFATNAHTNEV-----------VAIKKMSYSGKQTHEKWQDILKEVKFLRQ 78
Query: 71 LHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVCHALEYL 130
L P Y G + + ++VMEYC E I H L YL
Sbjct: 79 LKHPNTIEYKGCYLKEHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALHGLAYL 138
Query: 131 HEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFWMAPEI 190
H LIHRD+KA NILL + G+V+LAD G N+FVGTP+WMAPE+
Sbjct: 139 HSHALIHRDIKAGNILLTEPGQVKLADFGSASM---------ASPANSFVGTPYWMAPEV 189
Query: 191 I---KNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRNMDISP 247
I YDGK DIWSLGIT +EL KPP+ ++++M AL I + N L++ + +
Sbjct: 190 ILAMDEGQYDGKVDIWSLGITCIELAERKPPLFNMNAMSALYHIAQ-NDSPTLQSNEWTD 248
Query: 248 LGKDFIRSCLQQDPNQRPTCKQLLQHKWLKK 278
+ F+ CLQ+ P +RPT +LL+H ++++
Sbjct: 249 SFRRFVDYCLQKIPQERPTSAELLRHDFVRR 279
>Hs4505599 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 525
Score = 155 bits (391), Expect = 2e-37
Identities = 93/296 (31%), Positives = 154/296 (51%), Gaps = 22/296 (7%)
Query: 5 QQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKE 64
+++ E +G+G G V+ A + QE +AIK INL+ + +L++ E
Sbjct: 247 KKYTRYEKIGQGASGTVFTATDVALGQE-----------VAIKQINLQKQPKK-ELIINE 294
Query: 65 IYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVC 124
I + L P I ++ ++ L++VMEY + E + +
Sbjct: 295 ILVMKELKNPNIVNFLDSYLVGDELFVVMEYLAGGSLTDVVTETACMDEAQIAAVCRECL 354
Query: 125 HALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPF 184
ALE+LH ++IHRD+K+ N+LL +G V+L D G Q+ ++ +T VGTP+
Sbjct: 355 QALEFLHANQVIHRDIKSDNVLLGMEGSVKLTDFGFCAQITPEQSKR-----STMVGTPY 409
Query: 185 WMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRNMD 244
WMAPE++ ++Y K DIWSLGI +E++ G+PP + + ++AL I +
Sbjct: 410 WMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPEK 469
Query: 245 ISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKKC----SITN-IMEEITVMKTNQ 295
+SP+ +DF+ CL+ D +R + K+LLQH +LK S+T IM MK+N+
Sbjct: 470 LSPIFRDFLNRCLEMDVEKRGSAKELLQHPFLKLAKPLSSLTPLIMAAKEAMKSNR 525
>Hs5174701 [T] KOG0579 Ste20-like serine/threonine protein kinase
Length = 968
Score = 154 bits (390), Expect = 2e-37
Identities = 95/294 (32%), Positives = 151/294 (51%), Gaps = 25/294 (8%)
Query: 13 VGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEIYFLSTLH 72
+G G FG VY A K + LA + S E ++ + EI L+T
Sbjct: 42 LGDGAFGKVYKA------------KNKETGALAAAKVIETKSEEELEDYIVEIEILATCD 89
Query: 73 CPYITHYYGTFTGDCNLYIVMEYC-SXXXXXXXXXXXXXXTEQTTCFIILQVCHALEYLH 131
PYI G + D L+I++E+C TE + Q+ AL +LH
Sbjct: 90 HPYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLH 149
Query: 132 EKRLIHRDLKAANILLNDDGEVRLADLGVTGQ-LKFNSTRHGGKNLNTFVGTPFWMAPEI 190
KR+IHRDLKA N+L+ +G++RLAD GV+ + LK R ++F+GTP+WMAPE+
Sbjct: 150 SKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKR------DSFIGTPYWMAPEV 203
Query: 191 I-----KNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRNMDI 245
+ K+ YD K DIWSLGIT +E+ +PP L+ M+ L++I K + ++L
Sbjct: 204 VMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKW 263
Query: 246 SPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKKCSITNIMEEITVMKTNQILSK 299
S +DF++ L ++P RP+ QLL+H ++ + + E+ +++ +
Sbjct: 264 SVEFRDFLKIALDKNPETRPSAAQLLEHPFVSSITSNKALRELVAEAKAEVMEE 317
>Hs7706401 [T] KOG0577 Serine/threonine protein kinase
Length = 1235
Score = 154 bits (389), Expect = 3e-37
Identities = 100/288 (34%), Positives = 149/288 (51%), Gaps = 27/288 (9%)
Query: 7 FQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINL--EHSNEPIDLLLKE 64
F L +G G+FG VY A + +++ +AIK ++ + SNE ++KE
Sbjct: 28 FSDLREIGHGSFGAVYFARDVRNSEV-----------VAIKKMSYSGKQSNEKWQDIIKE 76
Query: 65 IYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVC 124
+ FL L P Y G + + ++VMEYC E +
Sbjct: 77 VRFLQKLRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGAL 136
Query: 125 HALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPF 184
L YLH +IHRD+KA NILL++ G V+L D G + N+FVGTP+
Sbjct: 137 QGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMA---------PANSFVGTPY 187
Query: 185 WMAPEII---KNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILR 241
WMAPE+I YDGK D+WSLGIT +EL KPP+ ++++M AL I + N +L+
Sbjct: 188 WMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQ-NESPVLQ 246
Query: 242 NMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKW-LKKCSITNIMEEI 288
+ S ++F+ SCLQ+ P RPT + LL+H++ L++ T IM+ I
Sbjct: 247 SGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRERPPTVIMDLI 294
>Hs4759208 [T] KOG0577 Serine/threonine protein kinase
Length = 1049
Score = 154 bits (389), Expect = 3e-37
Identities = 100/288 (34%), Positives = 149/288 (51%), Gaps = 27/288 (9%)
Query: 7 FQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINL--EHSNEPIDLLLKE 64
F L +G G+FG VY A + +++ +AIK ++ + SNE ++KE
Sbjct: 28 FSDLREIGHGSFGAVYFARDVRNSEV-----------VAIKKMSYSGKQSNEKWQDIIKE 76
Query: 65 IYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVC 124
+ FL L P Y G + + ++VMEYC E +
Sbjct: 77 VRFLQKLRHPNTIQYRGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGAL 136
Query: 125 HALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPF 184
L YLH +IHRD+KA NILL++ G V+L D G + N+FVGTP+
Sbjct: 137 QGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMA---------PANSFVGTPY 187
Query: 185 WMAPEII---KNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILR 241
WMAPE+I YDGK D+WSLGIT +EL KPP+ ++++M AL I + N +L+
Sbjct: 188 WMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQ-NESPVLQ 246
Query: 242 NMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKW-LKKCSITNIMEEI 288
+ S ++F+ SCLQ+ P RPT + LL+H++ L++ T IM+ I
Sbjct: 247 SGHWSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRERPPTVIMDLI 294
>Hs15451902 [T] KOG0576 Mitogen-activated protein kinase kinase kinase kinase
(MAP4K) germinal center kinase family
Length = 894
Score = 154 bits (388), Expect = 4e-37
Identities = 90/277 (32%), Positives = 142/277 (50%), Gaps = 22/277 (7%)
Query: 5 QQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKE 64
+ F+L++ +G G +GDVY A + + + AIK I LE E ++ +E
Sbjct: 14 EDFELIQRIGSGTYGDVYKARNVNTGELA-----------AIKVIKLE-PGEDFAVVQQE 61
Query: 65 IYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVC 124
I + P I Y+G++ L+I ME+C +E ++ +
Sbjct: 62 IIMMKDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETL 121
Query: 125 HALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPF 184
L YLH K +HRD+K ANILL D+G V+LAD GV+ Q+ + +F+GTP+
Sbjct: 122 QGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKR-----KSFIGTPY 176
Query: 185 WMAPEII---KNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLN--ADSI 239
WMAPE+ + Y+ CD+W++GIT +EL +PPM L M+AL + K N +
Sbjct: 177 WMAPEVAAVERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKL 236
Query: 240 LRNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWL 276
M S F++ L ++P +RPT ++LLQH ++
Sbjct: 237 KDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFV 273
>CE28273 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 1096
Score = 153 bits (387), Expect = 5e-37
Identities = 98/288 (34%), Positives = 146/288 (50%), Gaps = 34/288 (11%)
Query: 7 FQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEIY 66
F+L+E VG G +G VY ++ + Q AIK +N+ E D + EI
Sbjct: 21 FELIEVVGNGTYGQVYKGRHVKTAQLA-----------AIKIMNINEDEE--DEIKLEIN 67
Query: 67 FLST-LHCPYITHYYGTF-------TGDCN-LYIVMEYCSXXXXXXXXXXXXXXT--EQT 115
L H + YYG F TG + L++VME+C + E+
Sbjct: 68 MLKKHSHHRNVATYYGAFIKKLPSSTGKHDQLWLVMEFCGSGSITDLVKNTKGGSLKEEW 127
Query: 116 TCFIILQVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKN 175
+I ++ L +LH+ ++IHRD+K N+LL D EV+L D GV+ QL R
Sbjct: 128 IAYICREILRGLYHLHQSKVIHRDIKGQNVLLTDSAEVKLVDFGVSAQLDKTVGRR---- 183
Query: 176 LNTFVGTPFWMAPEIIK-----NQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMR 230
NTF+GTP+WMAPE+I +YD + D+WSLGIT LE+ G PP+ + M+AL
Sbjct: 184 -NTFIGTPYWMAPEVIACDESPEATYDSRSDLWSLGITALEMAEGHPPLCDMHPMRALFL 242
Query: 231 IPKLNADSILRNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKK 278
IP+ + RN + + FI + L +D +QRP LL+H ++K+
Sbjct: 243 IPRNPPPKLKRNKKWTKKFETFIETVLVKDYHQRPYTGALLRHPFIKE 290
>CE25673 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 1082
Score = 153 bits (387), Expect = 5e-37
Identities = 98/288 (34%), Positives = 146/288 (50%), Gaps = 34/288 (11%)
Query: 7 FQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEIY 66
F+L+E VG G +G VY ++ + Q AIK +N+ E D + EI
Sbjct: 21 FELIEVVGNGTYGQVYKGRHVKTAQLA-----------AIKIMNINEDEE--DEIKLEIN 67
Query: 67 FLST-LHCPYITHYYGTF-------TGDCN-LYIVMEYCSXXXXXXXXXXXXXXT--EQT 115
L H + YYG F TG + L++VME+C + E+
Sbjct: 68 MLKKHSHHRNVATYYGAFIKKLPSSTGKHDQLWLVMEFCGSGSITDLVKNTKGGSLKEEW 127
Query: 116 TCFIILQVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKN 175
+I ++ L +LH+ ++IHRD+K N+LL D EV+L D GV+ QL R
Sbjct: 128 IAYICREILRGLYHLHQSKVIHRDIKGQNVLLTDSAEVKLVDFGVSAQLDKTVGRR---- 183
Query: 176 LNTFVGTPFWMAPEIIK-----NQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMR 230
NTF+GTP+WMAPE+I +YD + D+WSLGIT LE+ G PP+ + M+AL
Sbjct: 184 -NTFIGTPYWMAPEVIACDESPEATYDSRSDLWSLGITALEMAEGHPPLCDMHPMRALFL 242
Query: 231 IPKLNADSILRNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKK 278
IP+ + RN + + FI + L +D +QRP LL+H ++K+
Sbjct: 243 IPRNPPPKLKRNKKWTKKFETFIETVLVKDYHQRPYTGALLRHPFIKE 290
>CE25672 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 1087
Score = 153 bits (387), Expect = 5e-37
Identities = 98/288 (34%), Positives = 146/288 (50%), Gaps = 34/288 (11%)
Query: 7 FQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEIY 66
F+L+E VG G +G VY ++ + Q AIK +N+ E D + EI
Sbjct: 21 FELIEVVGNGTYGQVYKGRHVKTAQLA-----------AIKIMNINEDEE--DEIKLEIN 67
Query: 67 FLST-LHCPYITHYYGTF-------TGDCN-LYIVMEYCSXXXXXXXXXXXXXXT--EQT 115
L H + YYG F TG + L++VME+C + E+
Sbjct: 68 MLKKHSHHRNVATYYGAFIKKLPSSTGKHDQLWLVMEFCGSGSITDLVKNTKGGSLKEEW 127
Query: 116 TCFIILQVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKN 175
+I ++ L +LH+ ++IHRD+K N+LL D EV+L D GV+ QL R
Sbjct: 128 IAYICREILRGLYHLHQSKVIHRDIKGQNVLLTDSAEVKLVDFGVSAQLDKTVGRR---- 183
Query: 176 LNTFVGTPFWMAPEIIK-----NQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMR 230
NTF+GTP+WMAPE+I +YD + D+WSLGIT LE+ G PP+ + M+AL
Sbjct: 184 -NTFIGTPYWMAPEVIACDESPEATYDSRSDLWSLGITALEMAEGHPPLCDMHPMRALFL 242
Query: 231 IPKLNADSILRNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKK 278
IP+ + RN + + FI + L +D +QRP LL+H ++K+
Sbjct: 243 IPRNPPPKLKRNKKWTKKFETFIETVLVKDYHQRPYTGALLRHPFIKE 290
>7291778 [T] KOG0579 Ste20-like serine/threonine protein kinase
Length = 1726
Score = 153 bits (386), Expect = 6e-37
Identities = 119/397 (29%), Positives = 186/397 (45%), Gaps = 37/397 (9%)
Query: 13 VGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEIYFLSTLH 72
+G G FG VY A + K K A C LE D ++ EI LS +
Sbjct: 43 LGDGAFGKVYKAQH----------KEQKRFAAAKMC-QLEDEENLSDHMV-EIDILSEIK 90
Query: 73 CPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXX-XTEQTTCFIILQVCHALEYLH 131
P I Y F+ D L++++EYC TE ++ + L +LH
Sbjct: 91 HPNIVELYEAFSIDDKLWMLIEYCDGGALDSIMVELEKPLTEPQIAYVCKHMTEGLTFLH 150
Query: 132 EKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFWMAPEII 191
++IHRDLKA N+LL +G V+LAD GV+ + K +H +TF+GTP+WMAPE++
Sbjct: 151 RNKVIHRDLKAGNVLLTMEGGVKLADFGVSAKNKHTMQKH-----DTFIGTPYWMAPELV 205
Query: 192 -----KNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRNMDIS 246
++ YD K DIWSLGIT +EL +PP S + M+ L++I K + + S
Sbjct: 206 LCETFRDNPYDHKVDIWSLGITLIELAQMEPPNSEMSPMRVLLKIQKSEPPKLEQPSRWS 265
Query: 247 PLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKK----CSITNIMEEITVMKTNQILSKEKP 302
DF++ L +DP RPT L+QH ++ + I +++ E +++ E
Sbjct: 266 KEFNDFLKKSLVKDPQVRPTTDVLMQHAFINRNLDAKPIKDLLLEYKAEVVEEVVDDETE 325
Query: 303 RSC--KPRFPLSDKVYKTNLPNQLESWRFEDESVLRFDGLGDIPNLYXXXXXXXXXXXSP 360
S KP P + ++T + L+ R S L+ D D +L +
Sbjct: 326 VSAPWKPMDPCAQ--HRTLVVQLLDEPR---NSALQLDLDDDSASLQSQDIDKLPGTPTS 380
Query: 361 LL--TKQQLRTPNISTPTSALSPTSMAISPKTNLSTP 395
+L K+Q + P+ S P +A + + A + T +TP
Sbjct: 381 ILRDAKEQSQ-PSSSLPIAAAATAAAAATTTTKATTP 416
>Hs14589909 [T] KOG0576 Mitogen-activated protein kinase kinase kinase kinase
(MAP4K) germinal center kinase family
Length = 846
Score = 152 bits (385), Expect = 8e-37
Identities = 92/295 (31%), Positives = 149/295 (50%), Gaps = 22/295 (7%)
Query: 5 QQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKE 64
Q ++L++ VG G +GDVY A + + + A+K I LE ++ L+ +E
Sbjct: 18 QDYELVQRVGSGTYGDVYKARNVHTGELA-----------AVKIIKLEPGDD-FSLIQQE 65
Query: 65 IYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVC 124
I+ + I Y+G++ L+I MEYC +E ++ +
Sbjct: 66 IFMVKECKHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETL 125
Query: 125 HALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPF 184
L YLH K +HRD+K ANILL D G+V+LAD GV ++ + +F+GTP+
Sbjct: 126 QGLAYLHTKGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKR-----KSFIGTPY 180
Query: 185 WMAPEII---KNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLN--ADSI 239
WMAPE+ KN Y+ CDIW++GIT +EL +PPM L M+AL + K N +
Sbjct: 181 WMAPEVAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKL 240
Query: 240 LRNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKKCSITNIMEEITVMKTN 294
S +F++ L ++P +RPT ++LL H ++ + ++ + + K N
Sbjct: 241 KDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFVAQPGLSRALAVELLDKVN 295
>Hs8393810_1 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 336
Score = 152 bits (385), Expect = 8e-37
Identities = 104/296 (35%), Positives = 156/296 (52%), Gaps = 37/296 (12%)
Query: 7 FQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHS-NEPIDLLLKEI 65
+++ E +GKG +G V+ + Q+ A+K ++ H +E I+ +
Sbjct: 21 WEITETIGKGTYGKVFKVLNKKNGQKA-----------AVKILDPIHDIDEEIEAEYNIL 69
Query: 66 YFLSTLHCPYITHYYGTF------TGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFI 119
LS P + +YG + GD L++V+E CS E+ + +
Sbjct: 70 KALSDH--PNVVRFYGIYFKKDKVNGD-KLWLVLELCSGGSVTDLVKGFLKRGERMSEPL 126
Query: 120 ILQVCH----ALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKN 175
I + H L++LH + IHRD+K NILL +G V+L D GV+ QL STRH
Sbjct: 127 IAYILHEALMGLQHLHNNKTIHRDVKGNNILLTTEGGVKLVDFGVSAQL--TSTRH---R 181
Query: 176 LNTFVGTPFWMAPEIIK-----NQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMR 230
NT VGTPFWMAPE+I + +YD +CD WSLGIT +EL +G PP++ L M+AL +
Sbjct: 182 RNTSVGTPFWMAPEVIACEQQLDTTYDARCDTWSLGITAIELGDGDPPLADLHPMRALFK 241
Query: 231 IPKLNADSILRNMDI-SPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKKCSITNIM 285
IP+ N LR ++ S DFI CL +D +RPT +LLQHK++ + ++M
Sbjct: 242 IPR-NPPPKLRQPELWSAEFNDFISKCLTKDYEKRPTVSELLQHKFITQIEGKDVM 296
>Hs20544910_1 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 336
Score = 152 bits (385), Expect = 8e-37
Identities = 104/296 (35%), Positives = 156/296 (52%), Gaps = 37/296 (12%)
Query: 7 FQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHS-NEPIDLLLKEI 65
+++ E +GKG +G V+ + Q+ A+K ++ H +E I+ +
Sbjct: 21 WEITETIGKGTYGKVFKVLNKKNGQKA-----------AVKILDPIHDIDEEIEAEYNIL 69
Query: 66 YFLSTLHCPYITHYYGTF------TGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFI 119
LS P + +YG + GD L++V+E CS E+ + +
Sbjct: 70 KALSDH--PNVVRFYGIYFKKDKVNGD-KLWLVLELCSGGSVTDLVKGFLKRGERMSEPL 126
Query: 120 ILQVCH----ALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKN 175
I + H L++LH + IHRD+K NILL +G V+L D GV+ QL STRH
Sbjct: 127 IAYILHEALMGLQHLHNNKTIHRDVKGNNILLTTEGGVKLVDFGVSAQL--TSTRH---R 181
Query: 176 LNTFVGTPFWMAPEIIK-----NQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMR 230
NT VGTPFWMAPE+I + +YD +CD WSLGIT +EL +G PP++ L M+AL +
Sbjct: 182 RNTSVGTPFWMAPEVIACEQQLDTTYDARCDTWSLGITAIELGDGDPPLADLHPMRALFK 241
Query: 231 IPKLNADSILRNMDI-SPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKKCSITNIM 285
IP+ N LR ++ S DFI CL +D +RPT +LLQHK++ + ++M
Sbjct: 242 IPR-NPPPKLRQPELWSAEFNDFISKCLTKDYEKRPTVSELLQHKFITQIEGKDVM 296
>At1g63700 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 883
Score = 152 bits (383), Expect = 1e-36
Identities = 100/267 (37%), Positives = 135/267 (50%), Gaps = 17/267 (6%)
Query: 13 VGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEIYFLSTLH 72
+G G+FG VYL G N E + K V L C + S E L +EI LS L
Sbjct: 406 LGMGSFGHVYL----GFNSESGEMCAMKEVTL---CSDDPKSRESAQQLGQEISVLSRLR 458
Query: 73 CPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVCHALEYLHE 132
I YYG+ T D LYI +EY S E Q+ L YLH
Sbjct: 459 HQNIVQYYGSETVDDKLYIYLEYVSGGSIYKLLQEYGQFGENAIRNYTQQILSGLAYLHA 518
Query: 133 KRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFWMAPEIIK 192
K +HRD+K ANIL++ G V++AD G+ + S +F G+P+WMAPE+IK
Sbjct: 519 KNTVHRDIKGANILVDPHGRVKVADFGMAKHITAQS------GPLSFKGSPYWMAPEVIK 572
Query: 193 NQSYDG-KCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRNMD-ISPLGK 250
N + DIWSLG T LE+ KPP S + + A+ +I N+ + D +S GK
Sbjct: 573 NSNGSNLAVDIWSLGCTVLEMATTKPPWSQYEGVPAMFKIG--NSKELPDIPDHLSEEGK 630
Query: 251 DFIRSCLQQDPNQRPTCKQLLQHKWLK 277
DF+R CLQ++P RPT QLL H +++
Sbjct: 631 DFVRKCLQRNPANRPTAAQLLDHAFVR 657
>7292249 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 979
Score = 152 bits (383), Expect = 1e-36
Identities = 99/285 (34%), Positives = 145/285 (50%), Gaps = 33/285 (11%)
Query: 7 FQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINL-EHSNEPIDLLLKEI 65
F+L+E VG G +G VY + + Q AIK +++ E E I L + +
Sbjct: 32 FELIEVVGNGTYGQVYKGRHTKTGQLA-----------AIKVMDVTEDEEEEIKLEINVL 80
Query: 66 YFLSTLHCPYITHYYGTFTG------DCNLYIVMEYCSXXXXXXXXXXXXXXT--EQTTC 117
S I YYG F D L++VMEYC + E+
Sbjct: 81 KKYSNHR--NIATYYGAFIKKSPPGKDDQLWLVMEYCGAGSVTDLVKSTKGQSLKEEWIA 138
Query: 118 FIILQVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLN 177
+I ++ L YLH ++IHRD+K N+LL D+ EV+L D GV+ QL R N
Sbjct: 139 YICREILRGLSYLHSNKVIHRDIKGQNVLLTDNAEVKLVDFGVSAQLDRTIGRR-----N 193
Query: 178 TFVGTPFWMAPEII-----KNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIP 232
TF+GTP+WMAPE+I + +YD + D+WSLGIT LE+ +PP+ L M+AL IP
Sbjct: 194 TFIGTPYWMAPEVIACDENPDATYDNRSDLWSLGITALEMAESQPPLCDLHPMRALFLIP 253
Query: 233 KLNADSILRNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLK 277
+ N+ L++ S FI + L +D +QRP + LL+H ++K
Sbjct: 254 R-NSPPRLKSKKWSKKFHGFIDTVLVKDYHQRPYTENLLKHGFIK 297
>7293601 [T] KOG0577 Serine/threonine protein kinase
Length = 1039
Score = 151 bits (381), Expect = 2e-36
Identities = 100/287 (34%), Positives = 148/287 (50%), Gaps = 26/287 (9%)
Query: 7 FQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINL--EHSNEPIDLLLKE 64
F+ L +G G+FG VY A + + + +AIK ++ + S E +LKE
Sbjct: 27 FEDLREIGHGSFGAVYYARC----------NLTREI-VAIKKMSYTGKQSQEKWQDILKE 75
Query: 65 IYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVC 124
I FL L+ P Y G + + ++VMEYC E I L V
Sbjct: 76 IRFLRQLNHPNTIEYKGCYLRESTAWLVMEYCVGSASDIIEVHKKPLHEDEIAAICLGVL 135
Query: 125 HALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPF 184
L YLH IHRD+KA NILL D+G V+LAD G + +K + N+FVGTP+
Sbjct: 136 SGLSYLHSLGRIHRDIKAGNILLTDNGVVKLADFG-SAAIKCPA--------NSFVGTPY 186
Query: 185 WMAPEII---KNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILR 241
WMAPE+I YDGK D+WSLGIT +EL KPP ++++M AL I + + ++ +
Sbjct: 187 WMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPYFNMNAMSALYHIAQNESPTLPK 246
Query: 242 NMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKKCSITNIMEEI 288
N D S F+ CL++ P +RP+ +LL H ++ + ++ E+
Sbjct: 247 N-DWSDAFCSFVELCLKKMPAERPSSAKLLTHAYVTRPRSDTVLLEL 292
>Hs7382496 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 545
Score = 150 bits (379), Expect = 4e-36
Identities = 87/273 (31%), Positives = 143/273 (51%), Gaps = 18/273 (6%)
Query: 5 QQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKE 64
+++ E +G+G G VY A + + QE +AIK +NL+ + +L++ E
Sbjct: 268 KKYTRFEKIGQGASGTVYTAMDVATGQE-----------VAIKQMNLQQQPKK-ELIINE 315
Query: 65 IYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVC 124
I + P I +Y ++ L++VMEY + Q + +
Sbjct: 316 ILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAA-VCRECL 374
Query: 125 HALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPF 184
ALE+LH ++IHRD+K+ NILL DG V+L D G Q+ ++ +T VGTP+
Sbjct: 375 QALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKR-----STMVGTPY 429
Query: 185 WMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRNMD 244
WMAPE++ ++Y K DIWSLGI +E++ G+PP + + ++AL I +
Sbjct: 430 WMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEK 489
Query: 245 ISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLK 277
+S + +DF+ CL D +R + K+LLQH++LK
Sbjct: 490 LSAIFRDFLNRCLDMDVEKRGSAKELLQHQFLK 522
>SPBC1604.14c [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 658
Score = 149 bits (377), Expect = 7e-36
Identities = 85/266 (31%), Positives = 139/266 (51%), Gaps = 18/266 (6%)
Query: 13 VGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEIYFLSTLH 72
+G+G GDVY A +G+N + +AIK +N+ + + ++ EI + + H
Sbjct: 392 IGQGASGDVYSARQVGTN-----------LSVAIKKMNINQQPKK-EFIVNEILVMKSHH 439
Query: 73 CPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVCHALEYLHE 132
I ++ TF L++VMEY Q I + L++LHE
Sbjct: 440 HKNIVNFIDTFFYKSELWMVMEYMRGGSLTEVVTNNTLSEGQIAA-ICKETLEGLQHLHE 498
Query: 133 KRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFWMAPEIIK 192
++HRD+K+ NILL+ G+++L D G Q+ N T+ T VGTP+WMAPE++
Sbjct: 499 NGIVHRDIKSDNILLSLQGDIKLTDFGFCAQIDSNMTKR-----TTMVGTPYWMAPEVVT 553
Query: 193 NQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRNMDISPLGKDF 252
+ Y K D+WSLGI +E++ G+PP + + ++AL I + I R +S + DF
Sbjct: 554 RKEYGFKVDVWSLGIMAIEMVEGEPPYLNENPLRALYLIATIGTPKISRPELLSSVFHDF 613
Query: 253 IRSCLQQDPNQRPTCKQLLQHKWLKK 278
+ L +P QRP+ +LL+H +LK+
Sbjct: 614 LSKSLTVNPKQRPSSGELLRHPFLKQ 639
>Hs7019543 [T] KOG0582 Ste20-like serine/threonine protein kinase
Length = 547
Score = 149 bits (377), Expect = 7e-36
Identities = 97/279 (34%), Positives = 138/279 (48%), Gaps = 16/279 (5%)
Query: 39 PKNVPLAIKCINLEHSNEPIDLLLKEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSX 98
P+ +AIK INLE +D LLKEI +S P + YY +F L++VM+ S
Sbjct: 86 PRQERVAIKRINLEKCQTSMDELLKEIQAMSQCSHPNVVTYYTSFVVKDELWLVMKLLSG 145
Query: 99 XXXXXXXXXXXXXTEQTT--------CFIILQVCHALEYLHEKRLIHRDLKAANILLNDD 150
E I+ +V L+YLH IHRDLKA NILL +D
Sbjct: 146 GSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGLDYLHRNGQIHRDLKAGNILLGED 205
Query: 151 GEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFWMAPEIIKN-QSYDGKCDIWSLGITT 209
G V++AD GV+ L K TFVGTP WMAPE+++ + YD K D+WS GIT
Sbjct: 206 GSVQIADFGVSAFLATGGDVTRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADMWSFGITA 265
Query: 210 LELLNGKPPMSHLDSMKALMRIPKLNADSILRNMD----ISPLGKDF---IRSCLQQDPN 262
+EL G P MK LM + + ++ ++ + GK F + CLQ+DP+
Sbjct: 266 IELATGAAPYHKYPPMKVLMLTLQNDPPTLETGVEDKEMMKKYGKSFRKLLSLCLQKDPS 325
Query: 263 QRPTCKQLLQHKWLKKCSITNIMEEITVMKTNQILSKEK 301
+RPT +LL+ K+ +K + E + +T I + K
Sbjct: 326 KRPTAAELLKCKFFQKAKNREYLIEKLLTRTPDIAQRAK 364
>At5g14720 [T] KOG0582 Ste20-like serine/threonine protein kinase
Length = 561
Score = 149 bits (377), Expect = 7e-36
Identities = 97/284 (34%), Positives = 148/284 (51%), Gaps = 24/284 (8%)
Query: 2 LSLQQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLL 61
L+ + ++L E +G G V+ A IP NV +AIK ++LE N +D +
Sbjct: 11 LNAKDYKLYEEIGDGVSATVHRALC-----------IPLNVVVAIKVLDLEKCNNDLDGI 59
Query: 62 LKEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXX--XXTEQTTCFI 119
+E+ +S ++ P + + +FT L++VM Y + E +
Sbjct: 60 RREVQTMSLINHPNVLQAHCSFTTGHQLWVVMPYMAGGSCLHIIKSSYPDGFEEPVIATL 119
Query: 120 ILQVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTF 179
+ + AL YLH IHRD+KA NILL+ +G V+LAD GV+ + R ++ NTF
Sbjct: 120 LRETLKALVYLHAHGHIHRDVKAGNILLDSNGAVKLADFGVSACMFDTGDRQ--RSRNTF 177
Query: 180 VGTPFWMAPEIIKN-QSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRI-----PK 233
VGTP WMAPE+++ YD K D+WS GIT LEL +G P S MK L+ P
Sbjct: 178 VGTPCWMAPEVMQQLHGYDFKADVWSFGITALELAHGHAPFSKYPPMKVLLMTLQNAPPG 237
Query: 234 LNADSILRNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLK 277
L+ + R+ S K+ + +CL +DP +RPT ++LL+H + K
Sbjct: 238 LDYE---RDKRFSKAFKEMVGTCLVKDPKKRPTSEKLLKHPFFK 278
>Hs22035600 [T] KOG0576 Mitogen-activated protein kinase kinase kinase kinase
(MAP4K) germinal center kinase family
Length = 820
Score = 149 bits (376), Expect = 9e-36
Identities = 90/306 (29%), Positives = 154/306 (49%), Gaps = 22/306 (7%)
Query: 6 QFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEI 65
+F+LL+ VG G +GDVY A +++ A+K + L+ ++ I L +EI
Sbjct: 15 RFELLQRVGAGTYGDVYKARDTVTSELA-----------AVKIVKLDPGDD-ISSLQQEI 62
Query: 66 YFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVCH 125
L P + Y G++ + L+I ME+C E+ ++ +
Sbjct: 63 TILRECRHPNVVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATGPLEERQIAYVCREALK 122
Query: 126 ALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFW 185
L +LH + IHRD+K AN+LL G+V+LAD GV+G+L + + +F+GTP+W
Sbjct: 123 GLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKR-----RSFIGTPYW 177
Query: 186 MAPEII---KNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPK--LNADSIL 240
MAPE+ + Y+ CD+W+LGIT +EL +PP+ HL M+ALM + K +
Sbjct: 178 MAPEVAAVERKGGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLR 237
Query: 241 RNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKKCSITNIMEEITVMKTNQILSKE 300
+ F++ L ++P +RPT ++LLQH + + ++ ++ ++ L
Sbjct: 238 DKTRWTQNFHHFLKLALTKNPKKRPTAEKLLQHPFTTQQLPRALLTQLLDKASDPHLGTP 297
Query: 301 KPRSCK 306
P C+
Sbjct: 298 SPEDCE 303
>CE07905 [T] KOG0579 Ste20-like serine/threonine protein kinase
Length = 1228
Score = 149 bits (376), Expect = 9e-36
Identities = 93/272 (34%), Positives = 142/272 (52%), Gaps = 23/272 (8%)
Query: 13 VGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEIYFLSTLH 72
+G G FG V A TDPK+ A K I ++ E D L+ EI LS
Sbjct: 40 LGDGAFGKVEKA------VSRTDPKLFA----ASKSIEIQEGEELEDFLV-EIEILSECK 88
Query: 73 C-PYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTC-FIILQVCHALEYL 130
P + Y T+ + L +++E+C ++ +I VC AL++L
Sbjct: 89 GHPVMLGLYSTYFFENKLTMLLEFCGGGAVDNIIVELGHVLKEDQIRYIGYYVCDALKWL 148
Query: 131 HEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFWMAPEI 190
H + +IHRDLKA NILL DG+VRLAD GV+ +LK + +TF+GTP+WMAPE+
Sbjct: 149 HSQNVIHRDLKAGNILLTQDGQVRLADFGVSAKLKSEREKR-----DTFIGTPYWMAPEV 203
Query: 191 I-----KNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRNMDI 245
+ K+Q YD DIWS GIT +E+ G+PP S + M+ ++++ K ++L+
Sbjct: 204 MACETFKDQPYDCISDIWSFGITLIEMAQGEPPHSDVSVMRVIIKVQKSEPPTLLQPSHW 263
Query: 246 SPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLK 277
+ D + CL +DP RP ++ +H+W +
Sbjct: 264 TRSFSDILTRCLVKDPRNRPPAAEIFKHQWFQ 295
>At1g54960 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 585
Score = 149 bits (375), Expect = 1e-35
Identities = 89/266 (33%), Positives = 134/266 (49%), Gaps = 9/266 (3%)
Query: 11 ECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEIYFLST 70
+ +G+G FG VY+ G N + + K V + C + E + I L +E+ L
Sbjct: 72 QLIGRGAFGTVYM----GMNLDSGELLAVKQVLITSNCASKEKTQAHIQELEEEVKLLKN 127
Query: 71 LHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVCHALEYL 130
L P I Y GT D L I++E+ E Q+ LEYL
Sbjct: 128 LSHPNIVRYLGTVREDETLNILLEFVPGGSISSLLEKFGAFPESVVRTYTNQLLLGLEYL 187
Query: 131 HEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFWMAPEI 190
H ++HRD+K ANIL+++ G ++LAD G + Q+ +T G K++ GTP+WMAPE+
Sbjct: 188 HNHAIMHRDIKGANILVDNQGCIKLADFGASKQVAELATISGAKSMK---GTPYWMAPEV 244
Query: 191 IKNQSYDGKCDIWSLGITTLELLNGKPPMS-HLDSMKALMRIPKLNADSILRNMDISPLG 249
I + DIWS+G T +E++ GK P S + A+ I + + + +IS
Sbjct: 245 ILQTGHSFSADIWSVGCTVIEMVTGKAPWSQQYKEIAAIFHIGTTKSHPPIPD-NISSDA 303
Query: 250 KDFIRSCLQQDPNQRPTCKQLLQHKW 275
DF+ CLQQ+PN RPT +LL+ KW
Sbjct: 304 NDFLLKCLQQEPNLRPTASELLKVKW 329
>Hs7661994 [T] KOG0579 Ste20-like serine/threonine protein kinase
Length = 1152
Score = 148 bits (374), Expect = 2e-35
Identities = 98/292 (33%), Positives = 154/292 (52%), Gaps = 23/292 (7%)
Query: 7 FQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEIY 66
++++ +G G FG VY A N+E + V A K I+ + S E ++ + EI
Sbjct: 34 WEIIGELGDGAFGKVYKAQ----NKETS-------VLAAAKVIDTK-SEEELEDYMVEID 81
Query: 67 FLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXX-XTEQTTCFIILQVCH 125
L++ P I F + NL+I++E+C+ TE + Q
Sbjct: 82 ILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLD 141
Query: 126 ALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFW 185
AL YLH+ ++IHRDLKA NIL DG+++LAD GV+ + R ++F+GTP+W
Sbjct: 142 ALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRR-----DSFIGTPYW 196
Query: 186 MAPEII-----KNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSIL 240
MAPE++ K++ YD K D+WSLGIT +E+ +PP L+ M+ L++I K ++
Sbjct: 197 MAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLA 256
Query: 241 RNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKKCSITNIMEEITVMK 292
+ S KDF++ CL+++ + R T QLLQH ++ S I E I K
Sbjct: 257 QPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPIRELIAEAK 308
>Hs4505601 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 544
Score = 148 bits (374), Expect = 2e-35
Identities = 86/273 (31%), Positives = 144/273 (52%), Gaps = 18/273 (6%)
Query: 5 QQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKE 64
+++ E +G+G G VY A + + QE +AIK +NL+ + +L++ E
Sbjct: 266 KKYTRFEKIGQGASGTVYTALDIATGQE-----------VAIKQMNLQQQPKK-ELIINE 313
Query: 65 IYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVC 124
I + P I +Y ++ L++VMEY + Q + +
Sbjct: 314 ILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAA-VCRECL 372
Query: 125 HALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPF 184
AL++LH ++IHRD+K+ NILL DG V+L D G Q+ ++ +T VGTP+
Sbjct: 373 QALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKR-----STMVGTPY 427
Query: 185 WMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRNMD 244
WMAPE++ ++Y K DIWSLGI +E++ G+PP + + ++AL I +
Sbjct: 428 WMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPER 487
Query: 245 ISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLK 277
+S + +DF+ CL+ D ++R + K+LLQH +LK
Sbjct: 488 LSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLK 520
>HsM4759010 [T] KOG0576 Mitogen-activated protein kinase kinase kinase kinase
(MAP4K) germinal center kinase family
Length = 819
Score = 148 bits (373), Expect = 2e-35
Identities = 90/306 (29%), Positives = 154/306 (49%), Gaps = 22/306 (7%)
Query: 6 QFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEI 65
+F+LL+ VG G +GDVY A +++ A+K + L+ ++ I L +EI
Sbjct: 14 RFELLQRVGAGTYGDVYKARDTVTSELA-----------AVKIVKLDPGDD-ISSLQQEI 61
Query: 66 YFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVCH 125
L P + Y G++ + L+I ME+C E+ ++ +
Sbjct: 62 TILRECRHPNVVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATGPLEERQIAYVCRERLK 121
Query: 126 ALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFW 185
L +LH + IHRD+K AN+LL G+V+LAD GV+G+L + + +F+GTP+W
Sbjct: 122 GLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKR-----RSFIGTPYW 176
Query: 186 MAPEII---KNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPK--LNADSIL 240
MAPE+ + Y+ CD+W+LGIT +EL +PP+ HL M+ALM + K +
Sbjct: 177 MAPEVAAVERKGGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLR 236
Query: 241 RNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKKCSITNIMEEITVMKTNQILSKE 300
+ F++ L ++P +RPT ++LLQH + + ++ ++ ++ L
Sbjct: 237 DKTRWTQNFHHFLKLALTKNPKKRPTAEKLLQHPFTTQQLPRALLTQLLDKASDPHLGTP 296
Query: 301 KPRSCK 306
P C+
Sbjct: 297 SPEDCE 302
>At4g10730 [T] KOG0582 Ste20-like serine/threonine protein kinase
Length = 693
Score = 148 bits (373), Expect = 2e-35
Identities = 95/285 (33%), Positives = 146/285 (50%), Gaps = 25/285 (8%)
Query: 5 QQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKE 64
+ ++L+E VG G V+ A YL P N +AIK ++L+ N +D + +E
Sbjct: 25 KDYKLMEEVGYGASAVVHRAIYL-----------PTNEVVAIKSLDLDRCNSNLDDIRRE 73
Query: 65 IYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXX--XXTEQTTCFIILQ 122
++ + P + + +F D +L++VM + + E C ++ +
Sbjct: 74 AQTMTLIDHPNVIKSFCSFAVDHHLWVVMPFMAQGSCLHLMKAAYPDGFEEAAICSMLKE 133
Query: 123 VCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGT 182
AL+YLH + IHRD+KA NILL+D GE++L D GV+ L N R + NTFVGT
Sbjct: 134 TLKALDYLHRQGHIHRDVKAGNILLDDTGEIKLGDFGVSACLFDNGDRQRAR--NTFVGT 191
Query: 183 PFWMAPEIIK-NQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRI-----PKLNA 236
P WMAPE+++ Y+ K DIWS GIT LEL +G P S MK L+ P L+
Sbjct: 192 PCWMAPEVLQPGSGYNSKADIWSFGITALELAHGHAPFSKYPPMKVLLMTIQNAPPGLDY 251
Query: 237 DS----ILRNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLK 277
D + + K+ + CL +D +RPT ++LL+H + K
Sbjct: 252 DRDKKFSKKMSSCAQSFKELVALCLVKDQTKRPTAEKLLKHSFFK 296
>At1g53570 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 608
Score = 148 bits (373), Expect = 2e-35
Identities = 101/301 (33%), Positives = 148/301 (48%), Gaps = 37/301 (12%)
Query: 13 VGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINL----EHSNEPIDLLLKEIYFL 68
+G G FG VYL G N E K AIK + + + S E + L +EI L
Sbjct: 220 LGSGTFGQVYL----GFNSE-------KGKMCAIKEVKVISDDQTSKECLKQLNQEINLL 268
Query: 69 STLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVCHALE 128
+ L P I YYG+ + L + +EY S TE Q+ L
Sbjct: 269 NQLCHPNIVQYYGSELSEETLSVYLEYVSGGSIHKLLKDYGSFTEPVIQNYTRQILAGLA 328
Query: 129 YLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFWMAP 188
YLH + +HRD+K ANIL++ +GE++LAD G+ + ST + +F G+P+WMAP
Sbjct: 329 YLHGRNTVHRDIKGANILVDPNGEIKLADFGMAKHVTAFST------MLSFKGSPYWMAP 382
Query: 189 EIIKNQS-YDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRNMDISP 247
E++ +Q+ Y DIWSLG T LE+ KPP S + + A+ +I + D+ +S
Sbjct: 383 EVVMSQNGYTHAVDIWSLGCTILEMATSKPPWSQFEGVAAIFKIGN-SKDTPEIPDHLSN 441
Query: 248 LGKDFIRSCLQQDPNQRPTCKQLLQHKWLKKCSITNIMEEITVMKTNQILSKEKPRSCKP 307
K+FIR CLQ++P RPT QLL+H +L+ T ++ S P+ P
Sbjct: 442 DAKNFIRLCLQRNPTVRPTASQLLEHPFLR--------------NTTRVASTSLPKDFPP 487
Query: 308 R 308
R
Sbjct: 488 R 488
>CE07599 [T] KOG0576 Mitogen-activated protein kinase kinase kinase kinase
(MAP4K) germinal center kinase family
Length = 829
Score = 147 bits (372), Expect = 3e-35
Identities = 91/270 (33%), Positives = 139/270 (50%), Gaps = 22/270 (8%)
Query: 7 FQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEIY 66
++LL+ VG G +G+VY A + S+ A+K + LE + + ++ +EI
Sbjct: 15 YELLQRVGSGTYGEVYKARDIRSDSLA-----------AVKVVKLE-AGDNFAVIQQEIM 62
Query: 67 FLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVCHA 126
+ P I Y+G++ L+IVMEYC +E F+ +
Sbjct: 63 VIRECSHPNIIAYFGSYIRRDRLWIVMEYCGGGSLQDIYHLTGPLSELQIAFVCRETLRG 122
Query: 127 LEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFWM 186
L YLH IHRD+K ANILL+ G+V+LAD GV Q+ T GK +F+GTP+WM
Sbjct: 123 LNYLHNMGKIHRDIKGANILLSSSGDVKLADFGVAAQI----TATIGKR-KSFIGTPYWM 177
Query: 187 APEII---KNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPK--LNADSILR 241
APE+ K Y +CD+W+ GIT +EL +PP+ L M+ L + K +
Sbjct: 178 APEVACVEKRGGYGMQCDVWATGITAIELGECQPPLFDLHPMQVLYLMTKSGYKPPHLKD 237
Query: 242 NMDISPLGKDFIRSCLQQDPNQRPTCKQLL 271
+PL DF+R CL ++P +RP+ ++LL
Sbjct: 238 KHRWTPLFHDFVRQCLTKNPKKRPSPEKLL 267
>HsM4758524 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 1165
Score = 146 bits (368), Expect = 8e-35
Identities = 96/285 (33%), Positives = 144/285 (49%), Gaps = 33/285 (11%)
Query: 7 FQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINL-EHSNEPIDLLLKEI 65
F+L+E VG G +G VY ++ + Q AIK +++ E E I L + +
Sbjct: 25 FELVEVVGNGTYGQVYKGRHVKTGQLA-----------AIKVMDVTEDEEEEIKLEINML 73
Query: 66 YFLSTLHCPYITHYYGTFTG------DCNLYIVMEYCSXXXXXXXXXXXXXXT--EQTTC 117
S H I YYG F D L++VME+C T E
Sbjct: 74 KKYS--HHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIA 131
Query: 118 FIILQVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLN 177
+I ++ L +LH +IHRD+K N+LL ++ EV+L D GV+ QL R N
Sbjct: 132 YISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRR-----N 186
Query: 178 TFVGTPFWMAPEII-----KNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIP 232
TF+GTP+WMAPE+I + +YD + D+WS GIT +E+ G PP+ + M+AL IP
Sbjct: 187 TFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIP 246
Query: 233 KLNADSILRNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLK 277
+ N L++ S FI CL ++ QRP+ +QLL+H +++
Sbjct: 247 R-NPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIR 290
>Hs22035606 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 1212
Score = 146 bits (368), Expect = 8e-35
Identities = 96/285 (33%), Positives = 144/285 (49%), Gaps = 33/285 (11%)
Query: 7 FQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINL-EHSNEPIDLLLKEI 65
F+L+E VG G +G VY ++ + Q AIK +++ E E I L + +
Sbjct: 25 FELVEVVGNGTYGQVYKGRHVKTGQLA-----------AIKVMDVTEDEEEEIKLEINML 73
Query: 66 YFLSTLHCPYITHYYGTFTG------DCNLYIVMEYCSXXXXXXXXXXXXXXT--EQTTC 117
S H I YYG F D L++VME+C T E
Sbjct: 74 KKYS--HHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIA 131
Query: 118 FIILQVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLN 177
+I ++ L +LH +IHRD+K N+LL ++ EV+L D GV+ QL R N
Sbjct: 132 YISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRR-----N 186
Query: 178 TFVGTPFWMAPEII-----KNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIP 232
TF+GTP+WMAPE+I + +YD + D+WS GIT +E+ G PP+ + M+AL IP
Sbjct: 187 TFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIP 246
Query: 233 KLNADSILRNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLK 277
+ N L++ S FI CL ++ QRP+ +QLL+H +++
Sbjct: 247 R-NPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIR 290
>Hs22035604 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 1320
Score = 146 bits (368), Expect = 8e-35
Identities = 96/285 (33%), Positives = 144/285 (49%), Gaps = 33/285 (11%)
Query: 7 FQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINL-EHSNEPIDLLLKEI 65
F+L+E VG G +G VY ++ + Q AIK +++ E E I L + +
Sbjct: 25 FELVEVVGNGTYGQVYKGRHVKTGQLA-----------AIKVMDVTEDEEEEIKLEINML 73
Query: 66 YFLSTLHCPYITHYYGTFTG------DCNLYIVMEYCSXXXXXXXXXXXXXXT--EQTTC 117
S H I YYG F D L++VME+C T E
Sbjct: 74 KKYS--HHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIA 131
Query: 118 FIILQVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLN 177
+I ++ L +LH +IHRD+K N+LL ++ EV+L D GV+ QL R N
Sbjct: 132 YISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRR-----N 186
Query: 178 TFVGTPFWMAPEII-----KNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIP 232
TF+GTP+WMAPE+I + +YD + D+WS GIT +E+ G PP+ + M+AL IP
Sbjct: 187 TFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIP 246
Query: 233 KLNADSILRNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLK 277
+ N L++ S FI CL ++ QRP+ +QLL+H +++
Sbjct: 247 R-NPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIR 290
>Hs22035602 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 1166
Score = 146 bits (368), Expect = 8e-35
Identities = 96/285 (33%), Positives = 144/285 (49%), Gaps = 33/285 (11%)
Query: 7 FQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINL-EHSNEPIDLLLKEI 65
F+L+E VG G +G VY ++ + Q AIK +++ E E I L + +
Sbjct: 25 FELVEVVGNGTYGQVYKGRHVKTGQLA-----------AIKVMDVTEDEEEEIKLEINML 73
Query: 66 YFLSTLHCPYITHYYGTFTG------DCNLYIVMEYCSXXXXXXXXXXXXXXT--EQTTC 117
S H I YYG F D L++VME+C T E
Sbjct: 74 KKYS--HHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIA 131
Query: 118 FIILQVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLN 177
+I ++ L +LH +IHRD+K N+LL ++ EV+L D GV+ QL R N
Sbjct: 132 YISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRR-----N 186
Query: 178 TFVGTPFWMAPEII-----KNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIP 232
TF+GTP+WMAPE+I + +YD + D+WS GIT +E+ G PP+ + M+AL IP
Sbjct: 187 TFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIP 246
Query: 233 KLNADSILRNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLK 277
+ N L++ S FI CL ++ QRP+ +QLL+H +++
Sbjct: 247 R-NPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIR 290
>At3g07980 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 1367
Score = 145 bits (367), Expect = 1e-34
Identities = 97/275 (35%), Positives = 141/275 (51%), Gaps = 21/275 (7%)
Query: 6 QFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEH-SNEPIDLLLKE 64
++ L + +GKG +G VY+ G + E D +AIK ++LE+ E ++ +++E
Sbjct: 19 KYMLGDEIGKGAYGRVYI----GLDLENGDF-------VAIKQVSLENIGQEDLNTIMQE 67
Query: 65 IYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXT--EQTTCFIILQ 122
I L L+ I Y G+ +L+I++EY E I Q
Sbjct: 68 IDLLKNLNHKNIVKYLGSLKTKTHLHIILEYVENGSLANIIKPNKFGPFPESLVTVYIAQ 127
Query: 123 VCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGT 182
V L YLHE+ +IHRD+K ANIL +G V+LAD GV +L N ++ VGT
Sbjct: 128 VLEGLVYLHEQGVIHRDIKGANILTTKEGLVKLADFGVATKLN-----EADFNTHSVVGT 182
Query: 183 PFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRN 242
P+WMAPE+I+ DIWS+G T +ELL PP L M AL RI + + I +
Sbjct: 183 PYWMAPEVIELSGVCAASDIWSVGCTIIELLTCVPPYYDLQPMPALYRIVQDDTPPIPDS 242
Query: 243 MDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLK 277
+SP DF+R C ++D QRP K LL H W++
Sbjct: 243 --LSPDITDFLRLCFKKDSRQRPDAKTLLSHPWIR 275
>Hs7657335 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 1295
Score = 145 bits (366), Expect = 1e-34
Identities = 95/285 (33%), Positives = 144/285 (50%), Gaps = 33/285 (11%)
Query: 7 FQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEIY 66
F+L+E VG G +G VY ++ + Q AIK +++ E + + +EI
Sbjct: 25 FELVEVVGNGTYGQVYKGRHVKTGQLA-----------AIKVMDVTEDEE--EEIKQEIN 71
Query: 67 FLSTL-HCPYITHYYGTFT------GDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTC-- 117
L H I YYG F D L++VME+C + C
Sbjct: 72 MLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIA 131
Query: 118 FIILQVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLN 177
+I ++ L +LH ++IHRD+K N+LL ++ EV+L D GV+ QL R N
Sbjct: 132 YICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRR-----N 186
Query: 178 TFVGTPFWMAPEII-----KNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIP 232
TF+GTP+WMAPE+I + +YD + DIWSLGIT +E+ G PP+ + M+AL IP
Sbjct: 187 TFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIP 246
Query: 233 KLNADSILRNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLK 277
+ N L++ S DFI +CL + RP +QLL+ +++
Sbjct: 247 R-NPPPRLKSKKWSKKFIDFIDTCLIKTYLSRPPTEQLLKFPFIR 290
>SPAC1F5.09c [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 589
Score = 145 bits (365), Expect = 2e-34
Identities = 90/286 (31%), Positives = 144/286 (49%), Gaps = 14/286 (4%)
Query: 4 LQQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLK 63
++ F + +G+G G VYLA +G Q + AIK I+L+ +L+L
Sbjct: 306 VEYFNVKHKLGQGASGSVYLAKVVGGKQLGIFDSV------AIKSIDLQCQTRK-ELILN 358
Query: 64 EIYFLSTLHCPYITHYYGTF-TGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQ 122
EI + P I Y +F + +L++VMEY + TE I L+
Sbjct: 359 EITVMRESIHPNIVTYLDSFLVRERHLWVVMEYMNAGSLTDIIEKSKL-TEAQIARICLE 417
Query: 123 VCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGT 182
C +++LH + +IHRD+K+ N+LL++ G +++ D G +L + + T VGT
Sbjct: 418 TCKGIQHLHARNIIHRDIKSDNVLLDNSGNIKITDFGFCARLSNRTNKRV-----TMVGT 472
Query: 183 PFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRN 242
P+WMAPE++K Y K DIWSLGI +E++ +PP D ++AL I K ++ +
Sbjct: 473 PYWMAPEVVKQNEYGTKVDIWSLGIMIIEMIENEPPYLREDPIRALYLIAKNGTPTLKKP 532
Query: 243 MDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKKCSITNIMEEI 288
+S K F+ SCL D R T +LL H +L + T ++ I
Sbjct: 533 NLVSKNLKSFLNSCLTIDTIFRATAAELLTHSFLNQACPTEDLKSI 578
>At3g13530 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 1368
Score = 144 bits (364), Expect = 2e-34
Identities = 97/275 (35%), Positives = 139/275 (50%), Gaps = 21/275 (7%)
Query: 6 QFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHS-NEPIDLLLKE 64
++ L + +GKG +G VY G + E D +AIK ++LE+ E ++ +++E
Sbjct: 19 KYMLGDEIGKGAYGRVYK----GLDLENGDF-------VAIKQVSLENIVQEDLNTIMQE 67
Query: 65 IYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXT--EQTTCFIILQ 122
I L L+ I Y G+ +L+I++EY E I Q
Sbjct: 68 IDLLKNLNHKNIVKYLGSSKTKTHLHIILEYVENGSLANIIKPNKFGPFPESLVAVYIAQ 127
Query: 123 VCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGT 182
V L YLHE+ +IHRD+K ANIL +G V+LAD GV +L N ++ VGT
Sbjct: 128 VLEGLVYLHEQGVIHRDIKGANILTTKEGLVKLADFGVATKLN-----EADVNTHSVVGT 182
Query: 183 PFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRN 242
P+WMAPE+I+ DIWS+G T +ELL PP L M AL RI + D+
Sbjct: 183 PYWMAPEVIEMSGVCAASDIWSVGCTVIELLTCVPPYYDLQPMPALFRI--VQDDNPPIP 240
Query: 243 MDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLK 277
+SP DF+R C ++D QRP K LL H W++
Sbjct: 241 DSLSPDITDFLRQCFKKDSRQRPDAKTLLSHPWIR 275
>At3g06030 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 651
Score = 144 bits (364), Expect = 2e-34
Identities = 89/267 (33%), Positives = 135/267 (50%), Gaps = 9/267 (3%)
Query: 11 ECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEIYFLST 70
E +G G FG VY+ G N + + K V +A + E + I L +E+ L
Sbjct: 72 ELIGCGAFGRVYM----GMNLDSGELLAIKQVLIAPSSASKEKTQGHIRELEEEVQLLKN 127
Query: 71 LHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVCHALEYL 130
L P I Y GT +L I+ME+ E Q+ LEYL
Sbjct: 128 LSHPNIVRYLGTVRESDSLNILMEFVPGGSISSLLEKFGSFPEPVIIMYTKQLLLGLEYL 187
Query: 131 HEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFWMAPEI 190
H ++HRD+K ANIL+++ G +RLAD G + ++ +T +G K++ GTP+WMAPE+
Sbjct: 188 HNNGIMHRDIKGANILVDNKGCIRLADFGASKKVVELATVNGAKSMK---GTPYWMAPEV 244
Query: 191 IKNQSYDGKCDIWSLGITTLELLNGKPPMS-HLDSMKALMRIPKLNADSILRNMDISPLG 249
I + DIWS+G T +E+ GKPP S A++ I + A + D+SP
Sbjct: 245 ILQTGHSFSADIWSVGCTVIEMATGKPPWSEQYQQFAAVLHIGRTKAHPPIPE-DLSPEA 303
Query: 250 KDFIRSCLQQDPNQRPTCKQLLQHKWL 276
KDF+ CL ++P+ R + +LLQH ++
Sbjct: 304 KDFLMKCLHKEPSLRLSATELLQHPFV 330
>YOR231w [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 508
Score = 143 bits (361), Expect = 5e-34
Identities = 100/265 (37%), Positives = 136/265 (50%), Gaps = 25/265 (9%)
Query: 45 AIKCIN-LEHSNEPIDLLLKEIYFLSTLHCPYITHYYGTFTGDCN--LYIVMEYCSXXXX 101
A+K IN L E + +E+ F + YI YYG FT D N +YI MEY
Sbjct: 248 ALKVINTLNTDPEYQKQIFRELQFNRSFQSEYIVRYYGMFTDDENSSIYIAMEYMGGRSL 307
Query: 102 XXXXXXXXXX----TEQTTCFIILQVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLAD 157
+E+ I V L YLHEK++IHRD+K NILLN++G+V+L D
Sbjct: 308 DAIYKNLLERGGRISEKVLGKIAEAVLRGLSYLHEKKVIHRDIKPQNILLNENGQVKLCD 367
Query: 158 LGVTGQLKFNSTRHGGKNLNTFVGTPFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKP 217
GV+G+ NS TF GT F+MAPE I+ Q Y D+WSLG+T LE+ NGK
Sbjct: 368 FGVSGE-AVNSL------ATTFTGTSFYMAPERIQGQPYSVTSDVWSLGLTILEVANGKF 420
Query: 218 PMS------HLDSMKALMRI----PKLNADSILRNMDISPLGKDFIRSCLQQDPNQRPTC 267
P S ++ + LM I P+L D N+ SP K FI CL++D +RP+
Sbjct: 421 PCSSEKMAANIAPFELLMWILTFTPELK-DEPESNIIWSPSFKSFIDYCLKKDSRERPSP 479
Query: 268 KQLLQHKWLKKCSITNIMEEITVMK 292
+Q++ H W+K N+ E V K
Sbjct: 480 RQMINHPWIKGQMKKNVNMEKFVRK 504
>CE01405 [T] KOG0577 Serine/threonine protein kinase
Length = 982
Score = 143 bits (361), Expect = 5e-34
Identities = 99/304 (32%), Positives = 151/304 (49%), Gaps = 32/304 (10%)
Query: 5 QQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINL--EHSNEPIDLLL 62
Q++Q L +G G+FG VY A+ D K + V AIK +N + + E + +L
Sbjct: 28 QRYQDLREIGHGSFGAVYFAY---------DKKNEQTV--AIKKMNFSGKQAVEKWNDIL 76
Query: 63 KEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQ 122
KE+ FL+T+ P+I Y F D ++VMEYC E I Q
Sbjct: 77 KEVSFLNTVVHPHIVDYKACFLKDTTCWLVMEYCIGSAADIVDVLRKGMREVEIAAICSQ 136
Query: 123 VCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGT 182
AL YLH + IHRD+KA NILL+D V+LAD G + TF+GT
Sbjct: 137 TLDALRYLHSLKRIHRDIKAGNILLSDHAIVKLADFGSASLV---------DPAQTFIGT 187
Query: 183 PFWMAPEII---KNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSI 239
PF+MAPE+I Y + DIWSLGIT +EL +PP+ +++M AL I + N
Sbjct: 188 PFFMAPEVILAMDEGHYTDRADIWSLGITCIELAERRPPLFSMNAMSALYHIAQ-NDPPT 246
Query: 240 LRNMDISPLGK------DFIRSCLQQDPNQRPTCKQLLQHKWLKKCSITNIMEEITVMKT 293
L +D S + FI CL++ +R + ++ +H ++++ ++ ++E+
Sbjct: 247 LSPIDTSEQPEWSLEFVQFIDKCLRKPAEERMSAEECFRHPFIQRSRPSDTIQELIQRTK 306
Query: 294 NQIL 297
N +L
Sbjct: 307 NMVL 310
>YOL113w [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 655
Score = 143 bits (360), Expect = 7e-34
Identities = 89/287 (31%), Positives = 143/287 (49%), Gaps = 24/287 (8%)
Query: 7 FQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKN-------VPLAIKCINLEHSNEPID 59
FQL+E G+G G VYL+ + QE DP+ K+ +AIK I L +
Sbjct: 360 FQLVEKAGQGASGAVYLSKRIKLPQE-NDPRFLKSHCHRVVGERVAIKQIRLSEQPKK-Q 417
Query: 60 LLLKEIYFLSTLHCPYITHYYGTFT-GDCNLYIVMEYCS---------XXXXXXXXXXXX 109
L++ E+ ++ I ++ + D L+++MEY
Sbjct: 418 LIMNELLVMNDSRQENIVNFLEAYIIDDEELWVIMEYMEGGCLTDILDAVARSNTGEHSS 477
Query: 110 XXTEQTTCFIILQVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNST 169
E +I+ + C L++LH K++IHRD+K+ NILLN G V++ D G +L +
Sbjct: 478 PLNENQMAYIVKETCQGLKFLHNKKIIHRDIKSDNILLNSQGLVKITDFGFCVELTEKRS 537
Query: 170 RHGGKNLNTFVGTPFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALM 229
+ T VGTP+WMAPEI+ + YD K D+WSLGI +E++ G+PP + D +KAL
Sbjct: 538 KRA-----TMVGTPYWMAPEIVNQKGYDEKVDVWSLGIMLIEMIEGEPPYLNEDPLKALY 592
Query: 230 RIPKLNADSILRNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWL 276
I + + +S K F+ +CLQ + R + ++LL ++L
Sbjct: 593 LIANNGSPKLRHPESVSKQTKQFLDACLQVNVESRASVRKLLTFEFL 639
>SPAC9G1.02 [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and related
serine/threonine protein kinases
Length = 1401
Score = 142 bits (359), Expect = 9e-34
Identities = 101/314 (32%), Positives = 146/314 (46%), Gaps = 42/314 (13%)
Query: 13 VGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSN---EPIDLLLKEIYFLS 69
V G FGDVY G N E D LA+K I L+ S +D + E+ L
Sbjct: 1043 VRSGMFGDVYT----GVNMETGDL-------LAVKEIKLQDSRTFRSTVDQIHNEMTVLE 1091
Query: 70 TLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVCHALEY 129
L+ P + YYG +YI ME+C E ++Q+ L Y
Sbjct: 1092 RLNHPNVVTYYGVEVHREKVYIFMEFCQGGSLADLLAHGRIEDENVLKVYVVQLLEGLAY 1151
Query: 130 LHEKRLIHRDLKAANILLNDDGEVRLADLG--------VTGQLKFNSTRHGGKNLNTFVG 181
+H + ++HRD+K ANILL+ G ++ +D G ++++ + L G
Sbjct: 1152 IHSQHILHRDIKPANILLDHRGMIKYSDFGSALYVSPPTDPEVRYEDIQ---PELQHLAG 1208
Query: 182 TPFWMAPEII--KNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALM-RIPKLNADS 238
TP +MAPEII + G DIWSLG LE++ G P S +D+ A+M + ++ S
Sbjct: 1209 TPMYMAPEIILGTKKGDFGAMDIWSLGCVILEMMTGSTPWSEMDNEWAIMYHVAAMHTPS 1268
Query: 239 ILRNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWL----KKCSI----------TNI 284
I +N IS L +DFI C ++DP QRP LL H W+ KK I T++
Sbjct: 1269 IPQNEKISSLARDFIEQCFERDPEQRPRAVDLLTHPWITDFRKKTIITMPPATITKKTSL 1328
Query: 285 MEEITVMKTNQILS 298
IT KT Q+L+
Sbjct: 1329 SHTITEEKTAQLLA 1342
>Hs6005810 [T] KOG0576 Mitogen-activated protein kinase kinase kinase kinase
(MAP4K) germinal center kinase family
Length = 833
Score = 142 bits (357), Expect = 1e-33
Identities = 86/273 (31%), Positives = 139/273 (50%), Gaps = 22/273 (8%)
Query: 7 FQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEIY 66
+ LL+ +G G +G+V+ A K+ ++ +A+K + +E ++ + L KEI
Sbjct: 17 YDLLQRLGGGTYGEVFKAR----------DKVSGDL-VALKMVKMEPDDD-VSTLQKEIL 64
Query: 67 FLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVCHA 126
L T I Y+G++ L+I ME+C +E ++ +V
Sbjct: 65 ILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQG 124
Query: 127 LEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFWM 186
L YLH ++ IHRD+K ANIL+ND GEVRLAD G++ Q+ R +F+GTP+WM
Sbjct: 125 LAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARR-----LSFIGTPYWM 179
Query: 187 APEIIK---NQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPK--LNADSILR 241
APE+ Y+ CDIWSLGIT +EL +PP+ + ++ L + K +
Sbjct: 180 APEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKE 239
Query: 242 NMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHK 274
S +FI+ L + P +RP+ ++L H+
Sbjct: 240 KGKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQ 272
>At5g66850 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 376
Score = 141 bits (356), Expect = 2e-33
Identities = 100/317 (31%), Positives = 151/317 (47%), Gaps = 27/317 (8%)
Query: 6 QFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEI 65
Q++ + +G+G FG VY+A SN E K V L + S E I L +EI
Sbjct: 4 QWKKGKLIGRGTFGSVYVA----SNSETGALCAMKEVELFP---DDPKSAECIKQLEQEI 56
Query: 66 YFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXX-XXXTEQTTCFIILQVC 124
LS L P I Y+G+ T + +I +EY TE +
Sbjct: 57 KLLSNLQHPNIVQYFGSETVEDRFFIYLEYVHPGSINKYIRDHCGTMTESVVRNFTRHIL 116
Query: 125 HALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPF 184
L YLH K+ +HRD+K AN+L++ G V+LAD G+ L G + + G+P+
Sbjct: 117 SGLAYLHNKKTVHRDIKGANLLVDASGVVKLADFGMAKHLT------GQRADLSLKGSPY 170
Query: 185 WMAPEII--------KNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNA 236
WMAPE++ N DIWSLG T +E+ GKPP S + A+ ++ +
Sbjct: 171 WMAPEVLMQAVMQKDSNPDLAFAVDIWSLGCTIIEMFTGKPPWSEFEGAAAMFKVMR--- 227
Query: 237 DSILRNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKKC--SITNIMEEITVMKTN 294
DS +SP GKDF+R C Q++P +RPT LL+H++LK + +++ +
Sbjct: 228 DSPPIPESMSPEGKDFLRLCFQRNPAERPTASMLLEHRFLKNSLQPTSPSNSDVSQLFNG 287
Query: 295 QILSKEKPRSCKPRFPL 311
+++ R KP F L
Sbjct: 288 MNITEPSSRREKPNFKL 304
>7300149 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 569
Score = 141 bits (356), Expect = 2e-33
Identities = 87/297 (29%), Positives = 149/297 (49%), Gaps = 26/297 (8%)
Query: 5 QQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKE 64
++++ + VGKG G V++A L + + +A+K I++++ + DL+L E
Sbjct: 291 ERYKTTQEVGKGASGIVFIAADLQNESQ-----------VAVKTIDMKNQSSK-DLILTE 338
Query: 65 IYFLSTLHCPYITHYYGTFT--GDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQ 122
I L + + ++ + + L++VMEY Q C + +
Sbjct: 339 IRVLKDFNHKNLVNFLDAYLLEPEDQLWVVMEYMDGGPLTDVVTETVMKERQIAC-VCRE 397
Query: 123 VCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGT 182
+A+ +LH K +IHRD+K+ N+LL DG V++ D G ++ G + T VGT
Sbjct: 398 TLYAISFLHAKGIIHRDIKSDNVLLGMDGSVKVTDFGFCANIE------GDEKRQTMVGT 451
Query: 183 PFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRN 242
P+WMAPE++ + Y K DIWS+GI +E++ G+PP + ++AL I I
Sbjct: 452 PYWMAPEVVTRKKYGKKVDIWSIGIMAIEMIEGQPPYLYETPLRALYLIAANGRPDIKSW 511
Query: 243 MDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKKCS-----ITNIMEEITVMKTN 294
+SP +DF+ CLQ + ++R T +LL H +L CS + NI V++ N
Sbjct: 512 DKLSPNLQDFLDRCLQVEVDRRATADELLSHPFLNDCSEVKALVPNIKAAKKVLRRN 568
>SPBC1D7.05c [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 362
Score = 141 bits (355), Expect = 2e-33
Identities = 89/268 (33%), Positives = 134/268 (49%), Gaps = 13/268 (4%)
Query: 13 VGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEIYFLSTLH 72
+G G+FG VYL G N + K V L + + + +D L EI L L
Sbjct: 103 IGSGSFGQVYL----GMNASSGELMAVKQVILDSVSESKDRHAKLLDALAGEIALLQELS 158
Query: 73 CPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVCHALEYLHE 132
+I Y G+ +L I +EY E I Q LEYLH
Sbjct: 159 HEHIVQYLGSNLNSDHLNIFLEYVPGGSVAGLLTMYGSFEETLVKNFIKQTLKGLEYLHS 218
Query: 133 KRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNST--RHGGKNLNTFVGTPFWMAPEI 190
+ ++HRD+K ANIL+++ G+++++D G++ +L+ NST + GG +F G+ FWMAPE+
Sbjct: 219 RGIVHRDIKGANILVDNKGKIKISDFGISKKLELNSTSTKTGGAR-PSFQGSSFWMAPEV 277
Query: 191 IKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRNM--DISPL 248
+K + K DIWSLG +E+L K P + D M+A+ RI ++IL +IS
Sbjct: 278 VKQTMHTEKTDIWSLGCLVIEMLTSKHPYPNCDQMQAIFRI----GENILPEFPSNISSS 333
Query: 249 GKDFIRSCLQQDPNQRPTCKQLLQHKWL 276
DF+ D N RPT +LL H ++
Sbjct: 334 AIDFLEKTFAIDCNLRPTASELLSHPFV 361
>At1g09000 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 666
Score = 141 bits (355), Expect = 2e-33
Identities = 87/267 (32%), Positives = 134/267 (49%), Gaps = 9/267 (3%)
Query: 11 ECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEIYFLST 70
+ +G+G FG VY+ G N + + K V +A + E + I L +E+ L
Sbjct: 73 QLIGRGAFGTVYM----GMNLDSGELLAVKQVLIAANFASKEKTQAHIQELEEEVKLLKN 128
Query: 71 LHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVCHALEYL 130
L P I Y GT D L I++E+ E Q+ LEYL
Sbjct: 129 LSHPNIVRYLGTVREDDTLNILLEFVPGGSISSLLEKFGPFPESVVRTYTRQLLLGLEYL 188
Query: 131 HEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFWMAPEI 190
H ++HRD+K ANIL+++ G ++LAD G + Q+ +T G K++ GTP+WMAPE+
Sbjct: 189 HNHAIMHRDIKGANILVDNKGCIKLADFGASKQVAELATMTGAKSMK---GTPYWMAPEV 245
Query: 191 IKNQSYDGKCDIWSLGITTLELLNGKPPMS-HLDSMKALMRIPKLNADSILRNMDISPLG 249
I + DIWS+G T +E++ GK P S + A+ I + + + +S
Sbjct: 246 ILQTGHSFSADIWSVGCTVIEMVTGKAPWSQQYKEVAAIFFIGTTKSHPPIPD-TLSSDA 304
Query: 250 KDFIRSCLQQDPNQRPTCKQLLQHKWL 276
KDF+ CLQ+ PN RPT +LL+H ++
Sbjct: 305 KDFLLKCLQEVPNLRPTASELLKHPFV 331
>7298926 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 704
Score = 139 bits (350), Expect = 9e-33
Identities = 84/273 (30%), Positives = 137/273 (49%), Gaps = 18/273 (6%)
Query: 5 QQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKE 64
+++ +E +G+G G VY A + E +AIK +NL + +L++ E
Sbjct: 428 RKYTKMEKIGQGASGTVYTAIESSTGME-----------VAIKQMNLSQQPKK-ELIINE 475
Query: 65 IYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVC 124
I + P + +Y ++ L++VMEY Q + +V
Sbjct: 476 ILVMRENKHPNVVNYLDSYLVSEELWVVMEYLPGGSLTDVVTETCMDEGQIAA-VCREVL 534
Query: 125 HALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPF 184
ALE+LH ++IHRD+K+ NILL DG V+L D G Q+ ++ T VGTP+
Sbjct: 535 QALEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFCAQISPEQSKR-----TTMVGTPY 589
Query: 185 WMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRNMD 244
WMAPE++ + Y K D+WSLGI +E++ G+PP + + +KAL I I
Sbjct: 590 WMAPEVVTRKQYGPKVDLWSLGIMAIEMVEGEPPYLNENPLKALYLIATNGKPEIKEKDK 649
Query: 245 ISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLK 277
+S +DF+ CL+ + ++R + LL+H +LK
Sbjct: 650 LSSAFQDFLDQCLEVEVDRRASALDLLKHPFLK 682
>CE21615 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 378
Score = 138 bits (348), Expect = 2e-32
Identities = 90/277 (32%), Positives = 144/277 (51%), Gaps = 22/277 (7%)
Query: 4 LQQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLK 63
L ++++ + +G G G V++A+ GS TD K +A K + ++LL
Sbjct: 105 LGKYEMKKQIGVGASGTVFVANVAGS----TDVVAVKR--MAFK------TQPKKEMLLT 152
Query: 64 EIYFLSTLHCPYITHYYGTFTGDCN-LYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQ 122
EI + P + +Y ++ D + L++VM+Y Q +LQ
Sbjct: 153 EIKVMKQYRHPNLVNYIESYLVDADDLWVVMDYLEGGNLTDVVVKTELDEGQIAA--VLQ 210
Query: 123 VC-HALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVG 181
C AL +LH ++HRD+K+ N+LL +GEV+L D+G Q++ S R +T VG
Sbjct: 211 ECLKALHFLHRHSIVHRDIKSDNVLLGMNGEVKLTDMGFCAQIQPGSKR------DTVVG 264
Query: 182 TPFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILR 241
TP+WM+PEI+ + Y+ K DIWSLGI LE+++G+PP +KA+ I + I +
Sbjct: 265 TPYWMSPEILNKKQYNYKVDIWSLGIMALEMIDGEPPYLRETPLKAIYLIAQNGKPEIKQ 324
Query: 242 NMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKK 278
+S +F+ CL DP+QR +LL H +LKK
Sbjct: 325 RDRLSSEFNNFLDKCLVVDPDQRADTTELLAHPFLKK 361
>Hs20428779_1 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 357
Score = 137 bits (346), Expect = 3e-32
Identities = 92/286 (32%), Positives = 140/286 (48%), Gaps = 33/286 (11%)
Query: 7 FQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCIN-LEHSNEPIDLLLKEI 65
++++E +GKG +G VY D + A+K ++ + +E I+ +
Sbjct: 27 WEIIETIGKGTYGKVYKV------TNKRDGSLA-----AVKILDPVSDMDEEIEAEYNIL 75
Query: 66 YFLSTLHCPYITHYYGTF--TGDC---NLYIVMEYCSXXXXXXXXXXXXX----XTEQTT 116
FL + P + +YG F C L++V+E C+ E
Sbjct: 76 QFLP--NHPNVVKFYGMFYKADHCVGGQLWLVLELCNGGSVTELVKGLLRCGQRLDEAMI 133
Query: 117 CFIILQVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNL 176
+I+ L++LH R+IHRD+K NILL +G V+L D GV+ QL R
Sbjct: 134 SYILYGALLGLQHLHNNRIIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRLRR----- 188
Query: 177 NTFVGTPFWMAPEIIK-----NQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRI 231
NT VGTPFWMAPE+I + SYD +CD+WSLGIT +EL +G PP+ + +K L +I
Sbjct: 189 NTSVGTPFWMAPEVIACEQQYDSSYDARCDVWSLGITAIELGDGDPPLFDMHPVKTLFKI 248
Query: 232 PKLNADSILRNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLK 277
P+ ++L FI CL +D +RP+ LL H ++K
Sbjct: 249 PRNPPPTLLHPEKWCEEFNHFISQCLIKDFERRPSVTHLLDHPFIK 294
>YHL007c [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 939
Score = 134 bits (338), Expect = 2e-31
Identities = 80/271 (29%), Positives = 138/271 (50%), Gaps = 18/271 (6%)
Query: 13 VGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEIYFLSTLH 72
+G+G G VY A+ +G+N V +AIK +NLE + +L++ EI +
Sbjct: 626 IGQGASGGVYTAYEIGTN-----------VSVAIKQMNLEKQPKK-ELIINEILVMKGSK 673
Query: 73 CPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVCHALEYLHE 132
P I ++ ++ +L+++MEY TE + + LE+LH
Sbjct: 674 HPNIVNFIDSYVLKGDLWVIMEYMEGGSLTDVVTHCIL-TEGQIGAVCRETLSGLEFLHS 732
Query: 133 KRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFWMAPEIIK 192
K ++HRD+K+ NILL+ +G+++L D G Q+ + + T VGTP+WMAPE++
Sbjct: 733 KGVLHRDIKSDNILLSMEGDIKLTDFGFCAQINELNLKR-----TTMVGTPYWMAPEVVS 787
Query: 193 NQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRNMDISPLGKDF 252
+ Y K DIWSLGI +E++ G+PP + ++AL I + ++S K F
Sbjct: 788 RKEYGPKVDIWSLGIMIIEMIEGEPPYLNETPLRALYLIATNGTPKLKEPENLSSSLKKF 847
Query: 253 IRSCLQQDPNQRPTCKQLLQHKWLKKCSITN 283
+ CL +P R + +LL +++ + + N
Sbjct: 848 LDWCLCVEPEDRASATELLHDEYITEIAEAN 878
>At4g08500 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 608
Score = 134 bits (338), Expect = 2e-31
Identities = 96/283 (33%), Positives = 139/283 (48%), Gaps = 32/283 (11%)
Query: 3 SLQQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINL----EHSNEPI 58
S Q+ QLL G+G+FG VY G A+K ++L + E I
Sbjct: 332 SWQKGQLL---GRGSFGSVYEG-ISGDGDF-----------FAVKEVSLLDQGSQAQECI 376
Query: 59 DLLLKEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCF 118
L EI LS L I Y GT NLYI +E + + +
Sbjct: 377 QQLEGEIKLLSQLQHQNIVRYRGTAKDGSNLYIFLELVTQGSLLKLYQRYQLRDSVVSLY 436
Query: 119 IILQVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNT 178
Q+ L+YLH+K IHRD+K ANIL++ +G V+LAD G+ KFN ++ +
Sbjct: 437 T-RQILDGLKYLHDKGFIHRDIKCANILVDANGAVKLADFGLAKVSKFN-------DIKS 488
Query: 179 FVGTPFWMAPEIIKNQSYDG---KCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLN 235
GTPFWMAPE+I + DG DIWSLG T LE+ G+ P S L+ ++AL RI +
Sbjct: 489 CKGTPFWMAPEVINRKDSDGYGSPADIWSLGCTVLEMCTGQIPYSDLEPVQALFRIGRGT 548
Query: 236 ADSILRNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKK 278
+ + + + FI CL+ +P +RPT +LL H ++++
Sbjct: 549 LPEVPDTLSLD--ARLFILKCLKVNPEERPTAAELLNHPFVRR 589
>Hs4505153 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 626
Score = 134 bits (337), Expect = 3e-31
Identities = 86/269 (31%), Positives = 129/269 (46%), Gaps = 25/269 (9%)
Query: 13 VGKGNFGDVYLAH------YLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEIY 66
+G+G FG VYL + L S Q DP P+ +++ + L EI
Sbjct: 368 LGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPE-------------TSKEVSALECEIQ 414
Query: 67 FLSTLHCPYITHYYGTFT--GDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVC 124
L L I YYG + L I MEY TE T Q+
Sbjct: 415 LLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQIL 474
Query: 125 HALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPF 184
+ YLH ++HRD+K ANIL + G V+L D G + +L+ + G + + GTP+
Sbjct: 475 EGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQ--TICMSGTGMRSVTGTPY 532
Query: 185 WMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRNMD 244
WM+PE+I + Y K D+WSLG T +E+L KPP + ++M A+ +I + L +
Sbjct: 533 WMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPS-H 591
Query: 245 ISPLGKDFIRSCLQQDPNQRPTCKQLLQH 273
IS G+DF+R + + QRP+ ++LL H
Sbjct: 592 ISEHGRDFLRR-IFVEARQRPSAEELLTH 619
>YNL298w [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 842
Score = 134 bits (336), Expect = 4e-31
Identities = 84/287 (29%), Positives = 137/287 (47%), Gaps = 26/287 (9%)
Query: 5 QQFQLLECVGKGNFGDVYLAHYLGS----------NQEPTDPKIPKNVPLAIKCINLEHS 54
Q F+++E G+G G VYLA N + +P + V + ++ +
Sbjct: 544 QCFKVIEKAGQGASGSVYLAERTHIPTESNMIELINNDIDEPHVGDKVAIKQMVLSKQPR 603
Query: 55 NEPIDLLLKEIYFLSTLHCPYITHYYGTFTG-DCNLYIVMEYCSXXXXX-------XXXX 106
E L++ EI + I ++ + D +L++VME+
Sbjct: 604 KE---LIVNEILVMKDSRHKNIVNFLEAYLRTDDDLWVVMEFMEGGSLTDIIENSPTNDN 660
Query: 107 XXXXXTEQTTCFIILQVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKF 166
TE +I+ + C L++LH+K +IHRD+K+ N+LL+ V++ D G +L
Sbjct: 661 SHSPLTEPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRARVKITDFGFCARLTD 720
Query: 167 NSTRHGGKNLNTFVGTPFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMK 226
++ T VGTP+WMAPE++K + YD K D+WSLGI T+E+L G+PP + D +K
Sbjct: 721 KRSKRA-----TMVGTPYWMAPEVVKQREYDEKIDVWSLGIMTIEMLEGEPPYLNEDPLK 775
Query: 227 ALMRIPKLNADSILRNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQH 273
AL I + +S K F+ CL D R + ++LL H
Sbjct: 776 ALYLIATNGTPKLKHPESLSLEIKRFLSVCLCVDVRYRASTEELLHH 822
>CE20564 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 540
Score = 132 bits (333), Expect = 9e-31
Identities = 83/290 (28%), Positives = 138/290 (46%), Gaps = 18/290 (6%)
Query: 13 VGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEIYFLSTLH 72
+G+G+ G V A+ + + Q +A+K +NL +LL E+ L
Sbjct: 255 IGEGSTGVVEAAYKISTKQI-----------VAVKRMNLRKQQRR-ELLFNEVSILRQYQ 302
Query: 73 CPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVCHALEYLHE 132
P I ++ + D L++VME+ TE I QV AL++LH
Sbjct: 303 HPNIVRFFSSHLVDDELWVVMEFMEGGSLTDIVTATRM-TEPQIATISRQVLGALDFLHA 361
Query: 133 KRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFWMAPEIIK 192
+++IHRD+K+ +ILL DG V+L D G GQL R + VGTP+W A E+I
Sbjct: 362 RKVIHRDIKSDSILLKRDGTVKLTDFGFCGQLSEEVPRR-----RSLVGTPYWTAAEVIA 416
Query: 193 NQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRNMDISPLGKDF 252
+ YD + DIWS GI +E++ G+PP + +A+ RI + R+ +S +
Sbjct: 417 REPYDTRADIWSFGIMLIEMVEGEPPFFNDQPFQAMKRIRDEHEARFSRHAKVSVELSEL 476
Query: 253 IRSCLQQDPNQRPTCKQLLQHKWLKKCSITNIMEEITVMKTNQILSKEKP 302
+ C+ +D N+R K LL+H + K ++ + + + ++ P
Sbjct: 477 LSHCIVKDVNKRWPAKDLLRHPFFAKAQHSSSIAPLLLQLQGNTINGNNP 526
>CE05425 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 542
Score = 132 bits (333), Expect = 9e-31
Identities = 83/290 (28%), Positives = 138/290 (46%), Gaps = 18/290 (6%)
Query: 13 VGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEIYFLSTLH 72
+G+G+ G V A+ + + Q +A+K +NL +LL E+ L
Sbjct: 257 IGEGSTGVVEAAYKISTKQI-----------VAVKRMNLRKQQRR-ELLFNEVSILRQYQ 304
Query: 73 CPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVCHALEYLHE 132
P I ++ + D L++VME+ TE I QV AL++LH
Sbjct: 305 HPNIVRFFSSHLVDDELWVVMEFMEGGSLTDIVTATRM-TEPQIATISRQVLGALDFLHA 363
Query: 133 KRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFWMAPEIIK 192
+++IHRD+K+ +ILL DG V+L D G GQL R + VGTP+W A E+I
Sbjct: 364 RKVIHRDIKSDSILLKRDGTVKLTDFGFCGQLSEEVPRR-----RSLVGTPYWTAAEVIA 418
Query: 193 NQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRNMDISPLGKDF 252
+ YD + DIWS GI +E++ G+PP + +A+ RI + R+ +S +
Sbjct: 419 REPYDTRADIWSFGIMLIEMVEGEPPFFNDQPFQAMKRIRDEHEARFSRHAKVSVELSEL 478
Query: 253 IRSCLQQDPNQRPTCKQLLQHKWLKKCSITNIMEEITVMKTNQILSKEKP 302
+ C+ +D N+R K LL+H + K ++ + + + ++ P
Sbjct: 479 LSHCIVKDVNKRWPAKDLLRHPFFAKAQHSSSIAPLLLQLQGNTINGNNP 528
>YAR019c [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 974
Score = 132 bits (332), Expect = 1e-30
Identities = 93/291 (31%), Positives = 139/291 (46%), Gaps = 30/291 (10%)
Query: 6 QFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEI 65
Q+ L + +G+G++G VY A ++Q +AIK + E+ E D++ EI
Sbjct: 24 QYHLKQVIGRGSYGVVYKAINKHTDQV-----------VAIKEVVYENDEELNDIMA-EI 71
Query: 66 YFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXX-TEQTTCFIILQVC 124
L L+ I Y+G LYI++EYC+ +E + + Q
Sbjct: 72 SLLKNLNHNNIVKYHGFIRKSYELYILLEYCANGSLRRLISRSSTGLSENESKTYVTQTL 131
Query: 125 HALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPF 184
L+YLH + +IHRD+KAANILL+ D V+LAD GV+ + ++ T GT
Sbjct: 132 LGLKYLHGEGVIHRDIKAANILLSADNTVKLADFGVSTIVNSSAL--------TLAGTLN 183
Query: 185 WMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRNMD 244
WMAPEI+ N+ DIWSLG T +E+L PP +L + D+
Sbjct: 184 WMAPEILGNRGASTLSDIWSLGATVVEMLTKNPPYHNLTDANIYYAVEN---DTYYPPSS 240
Query: 245 ISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKKCSITNIMEEITVMKTNQ 295
S KDF+ C ++ +RPT QLL+H W+ N E + V K N+
Sbjct: 241 FSEPLKDFLSKCFVKNMYKRPTADQLLKHVWI------NSTENVKVDKLNK 285
>YPL140c [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 506
Score = 132 bits (331), Expect = 2e-30
Identities = 82/248 (33%), Positives = 128/248 (51%), Gaps = 23/248 (9%)
Query: 45 AIKCINLEHSN-EPIDLLLKEIYFLSTLHCPYITHYYGTFTGD--CNLYIVMEYCSXXXX 101
A+K IN +++ E + +E+ F + YI YYG FT + ++YI MEY
Sbjct: 241 ALKTINTMNTDPEYQKQIFRELQFNKSFKSDYIVQYYGMFTDEQSSSIYIAMEYMGGKSL 300
Query: 102 XXXXXXXXXX----TEQTTCFIILQVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLAD 157
+E+ I V L YLHE+++IHRD+K NILLN+ GE++L D
Sbjct: 301 EATYKNLLKRGGRISERVIGKIAESVLRGLSYLHERKVIHRDIKPQNILLNEKGEIKLCD 360
Query: 158 LGVTGQLKFNSTRHGGKNLNTFVGTPFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKP 217
GV+G+ NS TF GT F+MAPE I+ Q Y CD+WSLG+T LE+ G+
Sbjct: 361 FGVSGE-AVNSL------AMTFTGTSFYMAPERIQGQPYSVTCDVWSLGLTLLEVAGGRF 413
Query: 218 P---------MSHLDSMKALMRIPKLNADSILRNMDISPLGKDFIRSCLQQDPNQRPTCK 268
P ++ ++ + ++ D ++ S + FI CL++D +RP+ +
Sbjct: 414 PFESDKITQNVAPIELLTMILTFSPQLKDEPELDISWSKTFRSFIDYCLKKDARERPSPR 473
Query: 269 QLLQHKWL 276
Q+L+H W+
Sbjct: 474 QMLKHPWI 481
>Hs22065797 [T] KOG0577 Serine/threonine protein kinase
Length = 897
Score = 131 bits (330), Expect = 2e-30
Identities = 73/184 (39%), Positives = 99/184 (53%), Gaps = 13/184 (7%)
Query: 93 MEYCSXXXXXXXXXXXXXXTEQTTCFIILQVCHALEYLHEKRLIHRDLKAANILLNDDGE 152
MEYC E I L YLH +IHRD+KA NILL + G+
Sbjct: 1 MEYCLGSASDLLEVHKKPLQEVEIAAITHGALQGLAYLHSHTMIHRDIKAGNILLTEPGQ 60
Query: 153 VRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFWMAPEII---KNQSYDGKCDIWSLGITT 209
V+LAD G N+FVGTP+WMAPE+I YDGK D+WSLGIT
Sbjct: 61 VKLADFGSASM---------ASPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITC 111
Query: 210 LELLNGKPPMSHLDSMKALMRIPKLNADSILRNMDISPLGKDFIRSCLQQDPNQRPTCKQ 269
+EL KPP+ ++++M AL I + N L++ + S ++F+ SCLQ+ P RPT ++
Sbjct: 112 IELAERKPPLFNMNAMSALYHIAQ-NESPTLQSNEWSDYFRNFVDSCLQKIPQDRPTSEE 170
Query: 270 LLQH 273
LL+H
Sbjct: 171 LLKH 174
>At4g26070 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 354
Score = 131 bits (330), Expect = 2e-30
Identities = 89/284 (31%), Positives = 138/284 (48%), Gaps = 25/284 (8%)
Query: 2 LSLQQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLL 61
LSL ++++ +GKG+ G+V L + + Q A+K I L +
Sbjct: 63 LSLADLEVIKVIGKGSSGNVQLVKHKLTQQF-----------FALKVIQLNTEESTCRAI 111
Query: 62 LKEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIIL 121
+E+ + CPY+ Y +F + + I++E+ E I
Sbjct: 112 SQELRINLSSQCPYLVSCYQSFYHNGLVSIILEFMDGGSLADLLKKVGKVPENMLSAICK 171
Query: 122 QVCHALEYLH-EKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFV 180
+V L Y+H E+R+IHRDLK +N+L+N GEV++ D GV+ L S+ N+FV
Sbjct: 172 RVLRGLCYIHHERRIIHRDLKPSNLLINHRGEVKITDFGVSKILTSTSSL-----ANSFV 226
Query: 181 GTPFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSIL 240
GT +M+PE I Y K DIWSLG+ LE GK P + + K + +L D+I+
Sbjct: 227 GTYPYMSPERISGSLYSNKSDIWSLGLVLLECATGKFPYTPPEHKKGWSSVYEL-VDAIV 285
Query: 241 RNMD-------ISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLK 277
N SP FI C+Q+DP R + K+LL+HK++K
Sbjct: 286 ENPPPCAPSNLFSPEFCSFISQCVQKDPRDRKSAKELLEHKFVK 329
>Hs4507275 [D] KOG0580 Serine/threonine protein kinase
Length = 403
Score = 130 bits (328), Expect = 3e-30
Identities = 82/277 (29%), Positives = 131/277 (46%), Gaps = 25/277 (9%)
Query: 3 SLQQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLL 62
+L+ F++ +GKG FG+VYLA Q + ++ +EH L
Sbjct: 129 ALEDFEIGRPLGKGKFGNVYLAR---EKQSKFILALKVLFKAQLEKAGVEHQ------LR 179
Query: 63 KEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQ 122
+E+ S L P I YG F +Y+++EY EQ T I +
Sbjct: 180 REVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITE 239
Query: 123 VCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGT 182
+ +AL Y H KR+IHRD+K N+LL GE+++AD G S T GT
Sbjct: 240 LANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGW-------SVHAPSSRRTTLCGT 292
Query: 183 PFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPM---SHLDSMKALMRIPKLNADSI 239
++ PE+I+ + +D K D+WSLG+ E L GKPP ++ ++ K + R+ D +
Sbjct: 293 LDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFV 352
Query: 240 LRNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWL 276
+D I L+ +P+QRP +++L+H W+
Sbjct: 353 TEG------ARDLISRLLKHNPSQRPMLREVLEHPWI 383
>HsM4507279 [D] KOG0580 Serine/threonine protein kinase
Length = 402
Score = 129 bits (325), Expect = 7e-30
Identities = 81/278 (29%), Positives = 132/278 (47%), Gaps = 25/278 (8%)
Query: 2 LSLQQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLL 61
++L+ F++ +GKG FG+VYLA Q + ++ +EH L
Sbjct: 127 VALEDFEIGRPLGKGKFGNVYLAR---EKQSKFILALKVLFKAQLEKAGVEHQ------L 177
Query: 62 LKEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIIL 121
+E+ S L P I YG F +Y+++EY EQ T +
Sbjct: 178 RREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTANLYN 237
Query: 122 QVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVG 181
++ +AL Y H KR+IHRD+K N+LL GE+++AD G S T G
Sbjct: 238 RIANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGW-------SVHAPSSRRTTLCG 290
Query: 182 TPFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPM---SHLDSMKALMRIPKLNADS 238
T ++ PE+I+ + +D K D+WSLG+ E L GKPP ++ ++ K + R+ D
Sbjct: 291 TLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDF 350
Query: 239 ILRNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWL 276
+ +D I L+ +P+QRP +++L+H W+
Sbjct: 351 VTEG------ARDLISRLLKHNPSQRPMLREVLEHPWI 382
>CE27670 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 572
Score = 129 bits (325), Expect = 7e-30
Identities = 81/273 (29%), Positives = 135/273 (48%), Gaps = 18/273 (6%)
Query: 5 QQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKE 64
++++ ++ +G G G VY A + + E +AIK +NL+ + +L++ E
Sbjct: 293 RKYRKVDKIGSGASGSVYTAIEISTEAE-----------VAIKQMNLKDQPKK-ELIINE 340
Query: 65 IYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVC 124
I + I +Y ++ L++VMEY + + + +V
Sbjct: 341 ILVMRENKHANIVNYLDSYLVCDELWVVMEYLAGGSLTDVVTECQME-DGIIAAVCREVL 399
Query: 125 HALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPF 184
ALE+LH + +IHRD+K+ NILL DG V+L D G QL + T VGTP+
Sbjct: 400 QALEFLHSRHVIHRDIKSDNILLGMDGSVKLTDFGFCAQLSPEQRKR-----TTMVGTPY 454
Query: 185 WMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRNMD 244
WMAPE++ + Y K D+WSLGI +E++ G+PP + + ++A+ I
Sbjct: 455 WMAPEVVTRKQYGPKVDVWSLGIMAIEMVEGEPPYLNENPLRAIYLIATNGKPDFPGRDS 514
Query: 245 ISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLK 277
++ L KDF+ S L+ R + QLL H +L+
Sbjct: 515 MTLLFKDFVDSALEVQVENRWSASQLLTHPFLR 547
>At3g61960 [OUT] KOG0595 Serine/threonine-protein kinase involved in autophagy
Length = 648
Score = 129 bits (324), Expect = 1e-29
Identities = 87/269 (32%), Positives = 128/269 (47%), Gaps = 17/269 (6%)
Query: 13 VGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEIYFLSTLH 72
+G G+F V+LA + S E +I K + S + D LLKEI LST+
Sbjct: 16 IGSGSFAVVWLAKHRSSGLEVAVKEIDKKLL----------SPKVRDNLLKEISILSTID 65
Query: 73 CPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVCHALEYLHE 132
P I +Y +++V+EYCS E + Q+ L+ L E
Sbjct: 66 HPNIIRFYEAIETGDRIFLVLEYCSGGDLAGYINRHGKVPEAVAKHFMRQLALGLQVLQE 125
Query: 133 KRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFWMAPEIIK 192
K IHRDLK N+LL+ L +G G F + TF G+P +MAPEII+
Sbjct: 126 KHFIHRDLKPQNLLLSSKEVTPLLKIGDFG---FARSLTPESMAETFCGSPLYMAPEIIR 182
Query: 193 NQSYDGKCDIWSLGITTLELLNGKPPM---SHLDSMKALMRIPKLNADSILRNMDISPLG 249
NQ YD K D+WS G +L+ GKPP +H+ ++R +L RN +I P
Sbjct: 183 NQKYDAKADLWSAGAILFQLVTGKPPFDGNNHIQLFHNIVRDTELKFPEDTRN-EIHPDC 241
Query: 250 KDFIRSCLQQDPNQRPTCKQLLQHKWLKK 278
D RS L+++P +R T ++ H +L++
Sbjct: 242 VDLCRSLLRRNPIERLTFREFFNHMFLRE 270
>Hs9910476 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 681
Score = 129 bits (323), Expect = 1e-29
Identities = 80/266 (30%), Positives = 134/266 (50%), Gaps = 22/266 (8%)
Query: 13 VGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEIYFLSTLH 72
+G+G+ G V LA S ++ +A+K ++L +LL E+ +
Sbjct: 413 IGEGSTGIVCLAREKHSGRQ-----------VAVKMMDLRKQQRR-ELLFNEVVIMRDYQ 460
Query: 73 CPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQ--TTCFIILQVCHALEYL 130
+ Y ++ L+++ME+ EQ T C +LQ AL YL
Sbjct: 461 HFNVVEMYKSYLVGEELWVLMEFLQGGALTDIVSQVRLNEEQIATVCEAVLQ---ALAYL 517
Query: 131 HEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFWMAPEI 190
H + +IHRD+K+ +ILL DG V+L+D G Q+ + + + VGTP+WMAPE+
Sbjct: 518 HAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKR-----KSLVGTPYWMAPEV 572
Query: 191 IKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRNMDISPLGK 250
I Y + DIWSLGI +E+++G+PP ++A+ R+ + + +SP+ +
Sbjct: 573 ISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLR 632
Query: 251 DFIRSCLQQDPNQRPTCKQLLQHKWL 276
DF+ L +DP +R T ++LL H +L
Sbjct: 633 DFLERMLVRDPQERATAQELLDHPFL 658
>SPAC1F3.02c [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 1116
Score = 128 bits (322), Expect = 2e-29
Identities = 80/275 (29%), Positives = 139/275 (50%), Gaps = 16/275 (5%)
Query: 11 ECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEIYFLST 70
E +G G +G V+LA + + + ++ +P I + + + +D + EI ++
Sbjct: 829 ELIGNGTYGKVFLAMNINTGELIAVKQV--EIPQTINGRHDQLRKDIVDSINAEISMIAD 886
Query: 71 LHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVCHALEYL 130
L I Y G + ++ I +EY S EQ F+ QV + L YL
Sbjct: 887 LDHLNIVQYLGFEKTETDISIFLEYVSGGSIGRCLRNYGPFEEQLVRFVSRQVLYGLSYL 946
Query: 131 HEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFWMAPEI 190
H K +IHRDLKA N+L++ DG +++D G++ K + + + G+ FWMAPE+
Sbjct: 947 HSKGIIHRDLKADNLLIDFDGVCKISDFGIS---KHSDNVYDNDANLSMQGSIFWMAPEV 1003
Query: 191 IKN--QSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRI------PKLNADSILRN 242
I N Q Y K D+WSLG LE+L G+ P S ++++A+ ++ P + ++ +
Sbjct: 1004 IHNDHQGYSAKVDVWSLGCVVLEMLAGRRPWSTDEAIQAMFKLGTEKKAPPIPSELV--- 1060
Query: 243 MDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLK 277
+SP F+ +C + + RPT ++LL H ++K
Sbjct: 1061 SQVSPEAIQFLNACFTVNADVRPTAEELLNHPFMK 1095
>Hs20479818 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 514
Score = 128 bits (321), Expect = 2e-29
Identities = 100/346 (28%), Positives = 161/346 (45%), Gaps = 38/346 (10%)
Query: 13 VGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHS-NEPIDLLLKEIYFLSTL 71
+GKG+FG V E TD + AIK +N E + + + LL +E+ L ++
Sbjct: 122 LGKGSFGIVI---------EATDKET--ETKWAIKKVNKEKAGSSAVKLLEREVNILKSV 170
Query: 72 HCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVCHALEYLH 131
+I H F +Y+VME C +E T +II + A+ YLH
Sbjct: 171 KHEHIIHLEQVFETPKKMYLVMELCEDGELKEILDRKGHFSENETRWIIQSLASAIAYLH 230
Query: 132 EKRLIHRDLKAANI-----LLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFWM 186
++HRDLK NI L++D+ E+ L L L GTP +M
Sbjct: 231 NNDIVHRDLKLENIMVKSSLIDDNNEINLNIKVTDFGLAVKKQSRSEAMLQATCGTPIYM 290
Query: 187 APEIIKNQSYDGKCDIWSLGITTLELLNGKPPM--SHLDSMKALMRIPKLNADSILRNMD 244
APE+I Y +CDIWS+G+ LL G+PP S + + L+R +L+ ++ + N
Sbjct: 291 APEVISAHDYSQQCDIWSIGVVMYMLLRGEPPFLASSEEKLFELIRKGELHFENAVWN-S 349
Query: 245 ISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWL---KKCSI--TNIM-------------E 286
IS K ++ ++ DP R T K+LL ++WL K S+ TN++ E
Sbjct: 350 ISDCAKSVLKQLMKVDPAHRITAKELLDNQWLTGNKLSSVRPTNVLEMMKEWKNNPESVE 409
Query: 287 EITVMKTNQILSKEKPRSCKPRFPLSDKVYKTNLPNQLESWRFEDE 332
E T + N+ ++EK +S +P + D Y ++ + +S +E +
Sbjct: 410 ENTTEEKNKPSTEEKLKSYQPWGNVPDANYTSDEEEEKQSTAYEKQ 455
>Hs14771959 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 719
Score = 128 bits (321), Expect = 2e-29
Identities = 80/265 (30%), Positives = 132/265 (49%), Gaps = 18/265 (6%)
Query: 13 VGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEIYFLSTLH 72
+G+G+ G V +A T+ K V A+K ++L +LL E+ + H
Sbjct: 455 IGEGSTGIVCIA---------TEKHTGKQV--AVKKMDLRKQQRR-ELLFNEVVIMRDYH 502
Query: 73 CPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVCHALEYLHE 132
+ Y ++ L++VME+ EQ + L V AL YLH
Sbjct: 503 HDNVVDMYSSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAT-VCLSVLRALSYLHN 561
Query: 133 KRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFWMAPEIIK 192
+ +IHRD+K+ +ILL DG ++L+D G Q+ + + VGTP+WMAPE+I
Sbjct: 562 QGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKR-----KSLVGTPYWMAPEVIS 616
Query: 193 NQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRNMDISPLGKDF 252
Y + DIWSLGI +E+++G+PP + ++A+ RI + +S + + F
Sbjct: 617 RLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPPRVKDLHKVSSVLRGF 676
Query: 253 IRSCLQQDPNQRPTCKQLLQHKWLK 277
+ L ++P+QR T ++LL H +LK
Sbjct: 677 LDLMLVREPSQRATAQELLGHPFLK 701
>YPL150w [T] KOG0583 Serine/threonine protein kinase
Length = 901
Score = 127 bits (319), Expect = 4e-29
Identities = 87/316 (27%), Positives = 149/316 (46%), Gaps = 39/316 (12%)
Query: 7 FQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEIY 66
+++L+ +G+G+FG VYLA + PT K+ C+ N+P +++E++
Sbjct: 41 YKILKQIGEGSFGKVYLALH-----RPTHRKV---------CLKTSDKNDPN--IVREVF 84
Query: 67 FLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVCHA 126
+ PYIT Y + +++ +EYC + + Q+ A
Sbjct: 85 YHRQFDFPYITKLYEVIVTESKVWMALEYCPGKELYDHLLSLRRISLLECGELFAQISGA 144
Query: 127 LEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFWM 186
+ Y H +HRDLK NILL+ +G +L D G T + +T L T GT +M
Sbjct: 145 VYYAHSMHCVHRDLKLENILLDKNGNAKLTDFGFTRECMTKTT------LETVCGTTVYM 198
Query: 187 APEIIKNQSYDG-KCDIWSLGITTLELLNGKPPMSHLDSMKALMRI----PKLNADSILR 241
APE+I+ ++YDG K DIWSLG+ L+ G P D K +I PK +A I
Sbjct: 199 APELIERRTYDGFKIDIWSLGVILYTLITGYLPFDDDDEAKTKWKIVNEEPKYDAKVIPD 258
Query: 242 NMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKKCSITNIMEEITVMKTNQILSKEK 301
+ +D I L ++P +RP+ Q+L+H +L+ + + +T +IL +++
Sbjct: 259 D------ARDLISRLLAKNPGERPSLSQVLRHPFLQPYG------SVVLDQTQKILCRQR 306
Query: 302 PRSCKPRFPLSDKVYK 317
+ + L ++ K
Sbjct: 307 SGGTQFKSKLERRLLK 322
>At4g29810 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 363
Score = 127 bits (319), Expect = 4e-29
Identities = 91/294 (30%), Positives = 136/294 (45%), Gaps = 31/294 (10%)
Query: 2 LSLQQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLL 61
LSL +++ +GKG+ G V L + + Q A+K I L +
Sbjct: 65 LSLSDLDMVKVIGKGSSGVVQLVQHKWTGQF-----------FALKVIQLNIDEAIRKAI 113
Query: 62 LKEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIIL 121
+E+ + CP + Y +F + + +++EY + I
Sbjct: 114 AQELKINQSSQCPNLVTSYQSFYDNGAISLILEYMDGGSLADFLKSVKAIPDSYLSAIFR 173
Query: 122 QVCHALEYLHEKR-LIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFV 180
QV L YLH R +IHRDLK +N+L+N GEV++ D GV+ + T G NTFV
Sbjct: 174 QVLQGLIYLHHDRHIIHRDLKPSNLLINHRGEVKITDFGVSTVM----TNTAGL-ANTFV 228
Query: 181 GTPFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPP----------MSHLDSMKALMR 230
GT +M+PE I Y K DIWSLG+ LE GK P S + M+A++
Sbjct: 229 GTYNYMSPERIVGNKYGNKSDIWSLGLVVLECATGKFPYAPPNQEETWTSVFELMEAIVD 288
Query: 231 IPKLNADSILRNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKKCSITNI 284
P L + + SP FI +CLQ+DPN R + K+L++H +L K + I
Sbjct: 289 QP----PPALPSGNFSPELSSFISTCLQKDPNSRSSAKELMEHPFLNKYDYSGI 338
>Hs5031975 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 591
Score = 127 bits (318), Expect = 5e-29
Identities = 84/267 (31%), Positives = 133/267 (49%), Gaps = 20/267 (7%)
Query: 13 VGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEIYFLSTLH 72
+G+G+ G V +A S + +A+K ++L +LL E+ +
Sbjct: 327 IGEGSTGIVCIATVRSSGKL-----------VAVKKMDLRKQQRR-ELLFNEVVIMRDYQ 374
Query: 73 CPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVCHALEYLHE 132
+ Y ++ L++VME+ EQ + L V AL LH
Sbjct: 375 HENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAA-VCLAVLQALSVLHA 433
Query: 133 KRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFWMAPEIIK 192
+ +IHRD+K+ +ILL DG V+L+D G Q+ R + VGTP+WMAPE+I
Sbjct: 434 QGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRR-----KSLVGTPYWMAPELIS 488
Query: 193 NQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRNM-DISPLGKD 251
Y + DIWSLGI +E+++G+PP + +KA M++ + N L+N+ +SP K
Sbjct: 489 RLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKA-MKMIRDNLPPRLKNLHKVSPSLKG 547
Query: 252 FIRSCLQQDPNQRPTCKQLLQHKWLKK 278
F+ L +DP QR T +LL+H +L K
Sbjct: 548 FLDRLLVRDPAQRATAAELLKHPFLAK 574
>YJL095w [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 1478
Score = 126 bits (316), Expect = 8e-29
Identities = 93/303 (30%), Positives = 144/303 (46%), Gaps = 22/303 (7%)
Query: 11 ECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEIYFLST 70
E +GKG+FG VYL N + K V + E ++ L E+ L
Sbjct: 1179 EMIGKGSFGAVYLC----LNVTTGEMMAVKQVEVPKYSSQNEAILSTVEALRSEVSTLKD 1234
Query: 71 LHCPYITHYYGTFTGDCNLY-IVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVCHALEY 129
L I Y G F N+Y + +EY + E + QV L Y
Sbjct: 1235 LDHLNIVQYLG-FENKNNIYSLFLEYVAGGSVGSLIRMYGRFDEPLIKHLTTQVLKGLAY 1293
Query: 130 LHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFWMAPE 189
LH K ++HRD+KA N+LL+ DG +++D G++ + K + ++ T GT FWMAPE
Sbjct: 1294 LHSKGILHRDMKADNLLLDQDGICKISDFGISRKSK---DIYSNSDM-TMRGTVFWMAPE 1349
Query: 190 II-KNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRI------PKLNADSILRN 242
++ Q Y K DIWSLG LE+ GK P S+L+ + A+ +I P + D++
Sbjct: 1350 MVDTKQGYSAKVDIWSLGCIVLEMFAGKRPWSNLEVVAAMFKIGKSKSAPPIPEDTLPL- 1408
Query: 243 MDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKKCSITNIMEE--ITVMKTNQILSKE 300
IS +G++F+ +C + +P +RPT +LL H + + N +K+N L+
Sbjct: 1409 --ISQIGRNFLDACFEINPEKRPTANELLSHPFSEVNETFNFKSTRLAKFIKSNDKLNSS 1466
Query: 301 KPR 303
K R
Sbjct: 1467 KLR 1469
>SPAC23C11.16 [D] KOG0575 Polo-like serine/threonine protein kinase
Length = 683
Score = 126 bits (316), Expect = 8e-29
Identities = 80/277 (28%), Positives = 129/277 (45%), Gaps = 38/277 (13%)
Query: 11 ECVGKG----------NFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDL 60
+C+G+G N+G++Y A + D K
Sbjct: 45 DCIGEGGFARCFRVKDNYGNIYAAKVIAKRSLQNDKTKLK-------------------- 84
Query: 61 LLKEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFII 120
L EI ++ P I + F N+Y+++E C TE +++
Sbjct: 85 LFGEIKVHQSMSHPNIVGFIDCFEDSTNIYLILELCEHKSLMELLRKRKQLTEPEVRYLM 144
Query: 121 LQVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFV 180
+Q+ AL+Y+H+KR+IHRDLK NI+L++ V++ D G+ L + R T
Sbjct: 145 MQILGALKYMHKKRVIHRDLKLGNIMLDESNNVKIGDFGLAALLMDDEERK-----MTIC 199
Query: 181 GTPFWMAPEIIKN--QSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADS 238
GTP ++APEI+ N + + + D+WS G+ LL GKPP + +K + R K N+ S
Sbjct: 200 GTPNYIAPEILFNSKEGHSFEVDLWSAGVVMYALLIGKPPFQDKE-VKTIYRKIKANSYS 258
Query: 239 ILRNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKW 275
N+DIS KD I S L DP+ RP+ ++ H++
Sbjct: 259 FPSNVDISAEAKDLISSLLTHDPSIRPSIDDIVDHEF 295
>YCR073c [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and related
serine/threonine protein kinases
Length = 1331
Score = 125 bits (314), Expect = 1e-28
Identities = 90/295 (30%), Positives = 135/295 (45%), Gaps = 41/295 (13%)
Query: 6 QFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSN---EPIDLLL 62
++Q +G G FG VY A L + + LA+K I + + + L+
Sbjct: 1033 RWQKRSFIGGGTFGQVYSAINLENGEI-----------LAVKEIKIHDTTTMKKIFPLIK 1081
Query: 63 KEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQ 122
+E+ L L+ P I YYG + I MEYC E T +
Sbjct: 1082 EEMTVLEMLNHPNIVQYYGVEVHRDKVNIFMEYCEGGSLASLLDHGRIEDEMVTQVYTFE 1141
Query: 123 VCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRH----------- 171
+ L YLH+ ++HRD+K NILL+ +G ++ D G + + TR
Sbjct: 1142 LLEGLAYLHQSGVVHRDIKPENILLDFNGIIKYVDFGTARTVVGSRTRTVRNAAVQDFGV 1201
Query: 172 GGKNLNTFVGTPFWMAPEIIKNQSYDGKC---DIWSLGITTLELLNGKPPMSHLDSMKAL 228
K+LN +GTP +MAPE I + GK D+W+LG LE+ G+ P S+LD+ A+
Sbjct: 1202 ETKSLNEMMGTPMYMAPETISGSAVKGKLGADDVWALGCVVLEMATGRRPWSNLDNEWAI 1261
Query: 229 M------RIPKL-NADSILRNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWL 276
M RIP+L N D +++ G+ F+ CL QDP R T +LL W+
Sbjct: 1262 MYHVAAGRIPQLPNRD------EMTAAGRAFLERCLVQDPTMRATAVELLIDPWM 1310
>Hs18602554 [T] KOG0578 p21-activated serine/threonine protein kinase
Length = 227
Score = 125 bits (313), Expect = 2e-28
Identities = 69/233 (29%), Positives = 121/233 (51%), Gaps = 11/233 (4%)
Query: 68 LSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVCHAL 127
+ L P I ++ ++ L++V+EY + Q + + AL
Sbjct: 1 MKELKNPNIVNFLDSYLVGDELFVVVEYLARGSLTDVVTETCMDEAQIAA-VCRESLQAL 59
Query: 128 EYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFWMA 187
E+LH ++IHRD+K+ ++LL +G V+L D G Q+ ++ +T V TP+WMA
Sbjct: 60 EFLHANQVIHRDIKSDSVLLGMEGSVKLTDFGFCAQITPEQSKR-----STVVRTPYWMA 114
Query: 188 PEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRNMDISP 247
PE++ ++Y K ++WSLGI E++ G+PP + + ++AL I + +SP
Sbjct: 115 PEVVTRKAYGPKVNVWSLGIMATEMVEGEPPYLNENPLRALCLIATNGIPELQNPETLSP 174
Query: 248 LGKDFIRSCLQQDPNQRPTCKQLLQHKWLKKCSITN-----IMEEITVMKTNQ 295
+ +DF+ CL+ D +R + K+LLQH +LK + + IM MK+N+
Sbjct: 175 IFRDFLNRCLETDVEKRGSAKELLQHLFLKLAKLLSSLTPLIMAAKEAMKSNR 227
>YNR031c [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and related
serine/threonine protein kinases
Length = 1579
Score = 124 bits (310), Expect = 4e-28
Identities = 88/305 (28%), Positives = 133/305 (42%), Gaps = 45/305 (14%)
Query: 6 QFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEP---IDLLL 62
++Q +G G FG VY A L + + LA+K IN++ S L+
Sbjct: 1265 RWQKRNFIGGGTFGRVYSAVDLDNGEI-----------LAVKEINIQDSKSMQKIFPLIK 1313
Query: 63 KEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQ 122
+E+ L L+ P I YYG + I MEYC E T LQ
Sbjct: 1314 EEMSVLEILNHPNIVSYYGVEVHRDKVNIFMEYCEGGSLAALLEHGRIEDEMVTQVYTLQ 1373
Query: 123 VCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKN------- 175
+ L YLHE ++HRD+K NILL+ +G ++ D G ++ N TR N
Sbjct: 1374 LLEGLAYLHESGIVHRDVKPENILLDFNGVIKYVDFGAAKKIANNGTRLASMNKIENADG 1433
Query: 176 --------------------LNTFVGTPFWMAPEIIKNQSYDGKC---DIWSLGITTLEL 212
L +GTP +MAPE I + GK D+WSLG LE+
Sbjct: 1434 EHEDVTHVSDSKAVKNNENALLDMMGTPMYMAPESITGSTTKGKLGADDVWSLGCVVLEM 1493
Query: 213 LNGKPPMSHLDSMKALM-RIPKLNADSILRNMDISPLGKDFIRSCLQQDPNQRPTCKQLL 271
+ G+ P ++LD+ A+M + + ++S G F+ CL Q+P++R + +LL
Sbjct: 1494 ITGRRPWANLDNEWAIMYHVAAGHTPQFPTKDEVSSAGMKFLERCLIQNPSKRASAVELL 1553
Query: 272 QHKWL 276
W+
Sbjct: 1554 MDPWI 1558
>HsM5729922 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 618
Score = 124 bits (310), Expect = 4e-28
Identities = 81/279 (29%), Positives = 133/279 (47%), Gaps = 27/279 (9%)
Query: 7 FQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLE----HSNEPIDLLL 62
++L + +G+G FG VYL + + + +E LA+K + + +++ ++ L
Sbjct: 355 WRLGKLLGQGAFGRVYLCYDVDTGRE-----------LAVKQVQFDPDSPETSKEVNALE 403
Query: 63 KEIYFLSTLHCPYITHYYGTFTG--DCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFII 120
EI L I YYG + L I MEY TE T
Sbjct: 404 CEIQLLKNFLHERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENGTRKYT 463
Query: 121 LQVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFV 180
Q+ + YLH ++HRD+K ANIL + G V+L D G + +L+ + G + +
Sbjct: 464 RQILEGVHYLHSNMILHRDIKGANILRDSTGNVKLGDFGASKRLQ--TICLSGTGMKSVT 521
Query: 181 GTPFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSIL 240
GTP+WM+PE+I Q Y K DIWS+ T +E+L KPP + ++M A+ +I
Sbjct: 522 GTPYWMSPEVISGQGYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPT---- 577
Query: 241 RNMDISPLGKDFIRSCLQQ---DPNQRPTCKQLLQHKWL 276
N + P D+ R L++ + RP+ +LL+H ++
Sbjct: 578 -NPKLPPHVSDYTRDFLKRIFVEAKLRPSADELLRHMFV 615
>Hs4507273 [D] KOG0580 Serine/threonine protein kinase
Length = 275
Score = 123 bits (309), Expect = 5e-28
Identities = 87/282 (30%), Positives = 133/282 (46%), Gaps = 31/282 (10%)
Query: 2 LSLQQFQLLECVGKGNFGDVYLA-----HYLGSNQEPTDPKIPKNVPLAIKCINLEHSNE 56
L++ F++ +GKG FG+VYLA H++ + + +I K LEH
Sbjct: 4 LTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKE--------GLEHQ-- 53
Query: 57 PIDLLLKEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTT 116
L +EI + L P I Y F +Y+++EY EQ T
Sbjct: 54 ----LRREIEIQAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRT 109
Query: 117 CFIILQVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNL 176
II +V AL Y H+K++IHRD+K N+LL GEV++AD G + +
Sbjct: 110 ATIIEEVADALTYCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPLPERK------ 163
Query: 177 NTFVGTPFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNA 236
T GT ++ PE+I+ ++YD K D+W +G+ ELL G PP + RI K++
Sbjct: 164 -TMCGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDV 222
Query: 237 DSILRNMDISPLG-KDFIRSCLQQDPNQRPTCKQLLQHKWLK 277
L PLG +D I L+ P +R Q+L+H W++
Sbjct: 223 RFPLS----MPLGARDLISRLLRYQPLERLPLAQILKHPWVQ 260
>7302570 [R] KOG0586 Serine/threonine protein kinase
Length = 702
Score = 123 bits (309), Expect = 5e-28
Identities = 83/279 (29%), Positives = 132/279 (46%), Gaps = 20/279 (7%)
Query: 1 MLSLQQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDL 60
+L + ++L + +GKGNF V LA + + + I K C+N E+ N+
Sbjct: 35 LLRVGYYELEKTIGKGNFAVVKLATNIVTKTKVAIKIIDKT------CLNEEYLNKTF-- 86
Query: 61 LLKEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFII 120
+EI L +L P+IT Y +Y+V EY E +
Sbjct: 87 --REIAILKSLRHPHITRLYEVMESQSMIYLVTEYAPNGEIFDHLVANGRMKEPEAARVF 144
Query: 121 LQVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFV 180
Q+ A+ Y H + ++HRDLKA N+LL+ D ++LAD G F++ G L T+
Sbjct: 145 TQLVSAVHYCHRRGVVHRDLKAENVLLDKDMNIKLADFG------FSNHYEEGATLKTWC 198
Query: 181 GTPFWMAPEIIKNQSYDG-KCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSI 239
G+P + APE+ + YDG K DIWSLG+ L+ G P D L ++
Sbjct: 199 GSPPYAAPEVFQGLEYDGPKSDIWSLGVVLYALVCGALP---FDGKTILELKSRVVLGKF 255
Query: 240 LRNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKK 278
+S + IR+ L +P++R T KQ+++H+WL +
Sbjct: 256 RIPFFMSQECEQLIRNMLVVEPDRRYTIKQIIKHRWLSE 294
>YMR001c [D] KOG0575 Polo-like serine/threonine protein kinase
Length = 705
Score = 123 bits (308), Expect = 7e-28
Identities = 73/219 (33%), Positives = 107/219 (48%), Gaps = 8/219 (3%)
Query: 61 LLKEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFII 120
LL EI ++ P I + F D N+YI++E C TE F
Sbjct: 126 LLSEIQIHKSMSHPNIVQFIDCFEDDSNVYILLEICPNGSLMELLKRRKVLTEPEVRFFT 185
Query: 121 LQVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFV 180
Q+C A++Y+H +R+IHRDLK NI + + +++ D G+ L S R T
Sbjct: 186 TQICGAIKYMHSRRVIHRDLKLGNIFFDSNYNLKIGDFGLAAVLANESERK-----YTIC 240
Query: 181 GTPFWMAPEII--KNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADS 238
GTP ++APE++ K+ + + DIWSLG+ LL GKPP D RI K S
Sbjct: 241 GTPNYIAPEVLMGKHSGHSFEVDIWSLGVMLYALLIGKPPFQARDVNTIYERI-KCRDFS 299
Query: 239 ILRNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLK 277
R+ IS GK IR L DP +RP+ +++ + W +
Sbjct: 300 FPRDKPISDEGKILIRDILSLDPIERPSLTEIMDYVWFR 338
>At4g08480 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 773
Score = 123 bits (308), Expect = 7e-28
Identities = 93/279 (33%), Positives = 131/279 (46%), Gaps = 24/279 (8%)
Query: 3 SLQQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLL 62
S Q+ QLL +G+FG VY A E D K V L + + E I L
Sbjct: 500 SWQKGQLLR---QGSFGSVYEAI-----SEDGDFFAVKEVSLLDQG---SQAQECIQQLE 548
Query: 63 KEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQ 122
EI LS L I Y GT NLYI +E + + + Q
Sbjct: 549 GEIALLSQLEHQNILRYRGTDKDGSNLYIFLELVTQGSLLELYRRYQIRDSLISLYT-KQ 607
Query: 123 VCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGT 182
+ L+YLH K IHRD+K A IL++ +G V+LAD G+ K N + + L
Sbjct: 608 ILDGLKYLHHKGFIHRDIKCATILVDANGTVKLADFGLAKVSKLNDIKSRKETL------ 661
Query: 183 PFWMAPEIIK---NQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSI 239
FWMAPE+I N Y DIWSLG T LE+ G+ P S L+ ++AL RI + +
Sbjct: 662 -FWMAPEVINRKDNDGYRSPADIWSLGCTVLEMCTGQIPYSDLEPVEALFRIRRGTLPEV 720
Query: 240 LRNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKK 278
+ + + FI CL+ +P +RPT +LL H ++++
Sbjct: 721 PDTLSLD--ARHFILKCLKLNPEERPTATELLNHPFVRR 757
>YLR362w [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 717
Score = 122 bits (307), Expect = 9e-28
Identities = 86/298 (28%), Positives = 131/298 (43%), Gaps = 38/298 (12%)
Query: 12 CVGKGNFGDVYLAHYLGSNQEPTDPKIP-KNVPLAI-----KCINLEHSNEP-------- 57
C+G G+FG VYL + + ++ KN + + K N + +NE
Sbjct: 420 CIGSGSFGSVYLGMNAHTGELMAVKQVEIKNNNIGVPTDNNKQANSDENNEQEEQQEKIE 479
Query: 58 ------------------IDLLLKEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXX 99
+D L E+ L LH I YYG NL I +EY
Sbjct: 480 DVGAVSHPKTNQNIHRKMVDALQHEMNLLKELHHENIVTYYGASQEGGNLNIFLEYVPGG 539
Query: 100 XXXXXXXXXXXXTEQTTCFIILQVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLG 159
E Q+ + YLH+K +IHRD+K ANIL++ G V++ D G
Sbjct: 540 SVSSMLNNYGPFEESLITNFTRQILIGVAYLHKKNIIHRDIKGANILIDIKGCVKITDFG 599
Query: 160 VTGQLK-FNSTRHGGKNLNTFVGTPFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPP 218
++ +L N ++ +L G+ FWM+PE++K + K DIWS G +E+ GK P
Sbjct: 600 ISKKLSPLNKKQNKRASLQ---GSVFWMSPEVVKQTATTAKADIWSTGCVVIEMFTGKHP 656
Query: 219 MSHLDSMKALMRIPKLNADSILRNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWL 276
M+A+ +I N + + S GK+F+R + D RP+ +LLQH WL
Sbjct: 657 FPDFSQMQAIFKI-GTNTTPEIPSWATSE-GKNFLRKAFELDYQYRPSALELLQHPWL 712
>At4g08470 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 560
Score = 122 bits (307), Expect = 9e-28
Identities = 87/269 (32%), Positives = 129/269 (47%), Gaps = 21/269 (7%)
Query: 11 ECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEIYFLST 70
+ +G+G++ VY A E D K V L K I + E I L EI LS
Sbjct: 307 QLLGRGSYASVYEAI-----SEDGDFFAVKEVSLLDKGIQAQ---ECIQQLEGEIALLSQ 358
Query: 71 LHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVCHALEYL 130
L I Y GT LYI +E + + + Q+ L YL
Sbjct: 359 LQHQNIVRYRGTAKDVSKLYIFLELVTQGSVQKLYERYQLSYTVVSLYT-RQILAGLNYL 417
Query: 131 HEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFWMAPEI 190
H+K +HRD+K AN+L++ +G V+LAD G+ KFN ++ + GT FWMAPE+
Sbjct: 418 HDKGFVHRDIKCANMLVDANGTVKLADFGLAEASKFN-------DIMSCKGTLFWMAPEV 470
Query: 191 IKNQSYDGK---CDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRNMDISP 247
I + DG DIWSLG T LE+ G+ P S L ++A +I + + + +
Sbjct: 471 INRKDSDGNGSPADIWSLGCTVLEMCTGQIPYSDLKPIQAAFKIGRGTLPDVPDTLSLD- 529
Query: 248 LGKDFIRSCLQQDPNQRPTCKQLLQHKWL 276
+ FI +CL+ +P +RPT +LL H ++
Sbjct: 530 -ARHFILTCLKVNPEERPTAAELLHHPFV 557
>Hs5453978 [T] KOG0614 cGMP-dependent protein kinase
Length = 762
Score = 122 bits (305), Expect = 2e-27
Identities = 83/279 (29%), Positives = 129/279 (45%), Gaps = 25/279 (8%)
Query: 5 QQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEH--SNEPIDLLL 62
Q +++ +G G FG V L +NV A+KCI +H + + +
Sbjct: 451 QNLEIIATLGVGGFGRVELVKVKN-----------ENVAFAMKCIRKKHIVDTKQQEHVY 499
Query: 63 KEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQ 122
E L L P+I Y TF + +Y+++E C E T+ F +
Sbjct: 500 SEKRILEELCSPFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVAC 559
Query: 123 VCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGT 182
V A +YLH +I+RDLK N++L+ +G ++L D G ++ G+ TF GT
Sbjct: 560 VTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFAKKIG------SGQKTWTFCGT 613
Query: 183 PFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRN 242
P ++APE+I N+ +D D WSLGI ELL G PP S +D M I K + +
Sbjct: 614 PEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFSGVDQMMTYNLILK-GIEKMDFP 672
Query: 243 MDISPLGKDFIRSCLQQDPNQR-----PTCKQLLQHKWL 276
I+ +D IR +Q+P +R + +H+WL
Sbjct: 673 RKITRRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWL 711
>Hs22065589 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 1191
Score = 122 bits (305), Expect = 2e-27
Identities = 69/192 (35%), Positives = 104/192 (53%), Gaps = 13/192 (6%)
Query: 93 MEYCSXXXXXXXXXXXXXXTEQTTC--FIILQVCHALEYLHEKRLIHRDLKAANILLNDD 150
ME+C + C +I ++ L +LH ++IHRD+K N+LL ++
Sbjct: 1 MEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTEN 60
Query: 151 GEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFWMAPEII-----KNQSYDGKCDIWSL 205
EV+L D GV+ QL R NTF+GTP+WMAPE+I + +YD + DIWSL
Sbjct: 61 AEVKLVDFGVSAQLDRTVGRR-----NTFIGTPYWMAPEVIACDENPDATYDYRSDIWSL 115
Query: 206 GITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRNMDISPLGKDFIRSCLQQDPNQRP 265
GIT +E+ G PP+ + M+AL IP+ N L++ S DFI +CL + RP
Sbjct: 116 GITAIEMAEGAPPLCDMHPMRALFLIPR-NPPPRLKSKKWSKKFIDFIDTCLIKTYLSRP 174
Query: 266 TCKQLLQHKWLK 277
+QLL+ +++
Sbjct: 175 PTEQLLKFPFIR 186
>SPCC320.12c [D] KOG0580 Serine/threonine protein kinase
Length = 384
Score = 121 bits (304), Expect = 2e-27
Identities = 82/278 (29%), Positives = 134/278 (47%), Gaps = 30/278 (10%)
Query: 7 FQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLL---- 62
F++ + +GKG FG VYLA ++ T +A+K + H +E + +
Sbjct: 118 FEIGKPLGKGKFGRVYLA-----KEKKT------GFIVALKTL---HKSELVQSKIEKQV 163
Query: 63 -KEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIIL 121
+EI S L I YG F + +Y+++E+ +E+ I
Sbjct: 164 RREIEIQSNLRHKNILRLYGHFHDEKRIYLILEFAGRGELYQHLRRAKRFSEEVASKYIF 223
Query: 122 QVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVG 181
Q+ +AL YLH+K +IHRD+K NILL DGE++L+D G S T G
Sbjct: 224 QMANALSYLHKKHVIHRDIKPENILLGIDGEIKLSDFGW-------SVHAPSNRRTTLCG 276
Query: 182 TPFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKA-LMRIPKLNADSIL 240
T ++ PE+++ + + K D+WSLG+ T E L G PP + A RI K++ +
Sbjct: 277 TLDYLPPEMVEGKEHTEKVDLWSLGVLTYEFLVGAPPFEDMSGHSATYKRIAKVD---LK 333
Query: 241 RNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKK 278
+ P +D I LQ +P +R + +Q+++H W+ K
Sbjct: 334 IPSFVPPDARDLISRLLQHNPEKRMSLEQVMRHPWIVK 371
>Hs4502553 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 370
Score = 121 bits (304), Expect = 2e-27
Identities = 86/275 (31%), Positives = 131/275 (47%), Gaps = 23/275 (8%)
Query: 7 FQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEIY 66
+ + +G G F +V LA D + K V AIKCI E + EI
Sbjct: 20 YDFRDVLGTGAFSEVILAE---------DKRTQKLV--AIKCIAKEALEGKEGSMENEIA 68
Query: 67 FLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVCHA 126
L + P I + +LY++M+ S TE+ +I QV A
Sbjct: 69 VLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDA 128
Query: 127 LEYLHEKRLIHRDLKAANIL---LNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTP 183
++YLH+ ++HRDLK N+L L++D ++ ++D G+ + G L+T GTP
Sbjct: 129 VKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGL------SKMEDPGSVLSTACGTP 182
Query: 184 FWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPK--LNADSILR 241
++APE++ + Y D WS+G+ LL G PP + K +I K DS
Sbjct: 183 GYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYW 242
Query: 242 NMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWL 276
+ DIS KDFIR +++DP +R TC+Q LQH W+
Sbjct: 243 D-DISDSAKDFIRHLMEKDPEKRFTCEQALQHPWI 276
>Hs10835242 [T] KOG0614 cGMP-dependent protein kinase
Length = 686
Score = 121 bits (304), Expect = 2e-27
Identities = 88/283 (31%), Positives = 125/283 (44%), Gaps = 24/283 (8%)
Query: 2 LSLQQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEH--SNEPID 59
L L F +++ +G G FG V L L S + T A+K + H +
Sbjct: 370 LKLSDFNIIDTLGVGGFGRVELVQ-LKSEESKT---------FAMKILKKRHIVDTRQQE 419
Query: 60 LLLKEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFI 119
+ E + H +I Y TF LY++ME C + TT F
Sbjct: 420 HIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFY 479
Query: 120 ILQVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTF 179
V A YLH K +I+RDLK N++L+ G +L D G ++ F GK TF
Sbjct: 480 TACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGF------GKKTWTF 533
Query: 180 VGTPFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSI 239
GTP ++APEII N+ +D D WSLGI ELL G PP S D MK I + D I
Sbjct: 534 CGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILR-GIDMI 592
Query: 240 LRNMDISPLGKDFIRSCLQQDPNQR-----PTCKQLLQHKWLK 277
I+ + I+ + +P++R K + +HKW +
Sbjct: 593 EFPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFE 635
>Hs9845489 [R] KOG0586 Serine/threonine protein kinase
Length = 691
Score = 121 bits (303), Expect = 3e-27
Identities = 78/277 (28%), Positives = 139/277 (50%), Gaps = 32/277 (11%)
Query: 7 FQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEP-IDLLLKEI 65
++LL+ +GKGNF V LA ++ + +E +A+K I+ N + L +E+
Sbjct: 20 YRLLKTIGKGNFAKVKLARHILTGKE-----------VAVKIIDKTQLNSSSLQKLFREV 68
Query: 66 YFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVCH 125
+ L+ P I + + LY+VMEY S E+ Q+
Sbjct: 69 RIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVS 128
Query: 126 ALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFW 185
A++Y H+K ++HRDLKA N+LL+ D +++AD G + + F G L+TF G+P +
Sbjct: 129 AVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTF------GNKLDTFCGSPPY 182
Query: 186 MAPEIIKNQSYDG-KCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRNMD 244
APE+ + + YDG + D+WSLG+ L++G P ++K L + +LR
Sbjct: 183 AAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDG-QNLKEL-------RERVLRGKY 234
Query: 245 ISPL-----GKDFIRSCLQQDPNQRPTCKQLLQHKWL 276
P ++ ++ L +P++R T +Q+++ +W+
Sbjct: 235 RIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWM 271
>Hs9845487 [R] KOG0586 Serine/threonine protein kinase
Length = 745
Score = 121 bits (303), Expect = 3e-27
Identities = 78/277 (28%), Positives = 139/277 (50%), Gaps = 32/277 (11%)
Query: 7 FQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEP-IDLLLKEI 65
++LL+ +GKGNF V LA ++ + +E +A+K I+ N + L +E+
Sbjct: 20 YRLLKTIGKGNFAKVKLARHILTGKE-----------VAVKIIDKTQLNSSSLQKLFREV 68
Query: 66 YFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVCH 125
+ L+ P I + + LY+VMEY S E+ Q+
Sbjct: 69 RIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVS 128
Query: 126 ALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFW 185
A++Y H+K ++HRDLKA N+LL+ D +++AD G + + F G L+TF G+P +
Sbjct: 129 AVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTF------GNKLDTFCGSPPY 182
Query: 186 MAPEIIKNQSYDG-KCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRNMD 244
APE+ + + YDG + D+WSLG+ L++G P ++K L + +LR
Sbjct: 183 AAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDG-QNLKEL-------RERVLRGKY 234
Query: 245 ISPL-----GKDFIRSCLQQDPNQRPTCKQLLQHKWL 276
P ++ ++ L +P++R T +Q+++ +W+
Sbjct: 235 RIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWM 271
>Hs22062450 [R] KOG0586 Serine/threonine protein kinase
Length = 787
Score = 121 bits (303), Expect = 3e-27
Identities = 78/277 (28%), Positives = 139/277 (50%), Gaps = 32/277 (11%)
Query: 7 FQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEP-IDLLLKEI 65
++LL+ +GKGNF V LA ++ + +E +A+K I+ N + L +E+
Sbjct: 53 YRLLKTIGKGNFAKVKLARHILTGKE-----------VAVKIIDKTQLNSSSLQKLFREV 101
Query: 66 YFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVCH 125
+ L+ P I + + LY+VMEY S E+ Q+
Sbjct: 102 RIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVS 161
Query: 126 ALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFW 185
A++Y H+K ++HRDLKA N+LL+ D +++AD G + + F G L+TF G+P +
Sbjct: 162 AVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTF------GNKLDTFCGSPPY 215
Query: 186 MAPEIIKNQSYDG-KCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRNMD 244
APE+ + + YDG + D+WSLG+ L++G P ++K L + +LR
Sbjct: 216 AAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDG-QNLKEL-------RERVLRGKY 267
Query: 245 ISPL-----GKDFIRSCLQQDPNQRPTCKQLLQHKWL 276
P ++ ++ L +P++R T +Q+++ +W+
Sbjct: 268 RIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWM 304
>Hs21735556 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 620
Score = 121 bits (303), Expect = 3e-27
Identities = 80/279 (28%), Positives = 133/279 (46%), Gaps = 27/279 (9%)
Query: 7 FQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLE----HSNEPIDLLL 62
++L + +G+G FG VYL + + + +E LA+K + + +++ ++ L
Sbjct: 357 WRLGKLLGQGAFGRVYLCYDVDTGRE-----------LAVKQVQFDPDSPETSKEVNALE 405
Query: 63 KEIYFLSTLHCPYITHYYGTFTG--DCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFII 120
EI L L I YYG + L I MEY TE T
Sbjct: 406 CEIQLLKNLLHERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYT 465
Query: 121 LQVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFV 180
Q+ + YLH ++ RD+K ANIL + G V+L D G + +L+ + G + +
Sbjct: 466 RQILEGVHYLHSNMIVLRDIKGANILRDSTGNVKLGDFGASKRLQ--TICLSGTGMKSVT 523
Query: 181 GTPFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSIL 240
GTP+WM+PE+I + Y K DIWS+ T +E+L KPP + ++M A+ +I
Sbjct: 524 GTPYWMSPEVISGEGYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPT---- 579
Query: 241 RNMDISPLGKDFIRSCLQQ---DPNQRPTCKQLLQHKWL 276
N + P D+ R L++ + RP+ +LL+H ++
Sbjct: 580 -NPKLPPHVSDYTRDFLKRIFVEAKLRPSADELLRHMFV 617
>At1g70430 [T] KOG0582 Ste20-like serine/threonine protein kinase
Length = 594
Score = 121 bits (303), Expect = 3e-27
Identities = 97/358 (27%), Positives = 164/358 (45%), Gaps = 41/358 (11%)
Query: 2 LSLQQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLL 61
L + ++L E VG+G VY A + N+ +A+K ++LE ++ +
Sbjct: 11 LYAKDYELFEEVGEGVSATVYRARCIALNEI-----------VAVKILDLEKCRNDLETI 59
Query: 62 LKEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXX--XXTEQTTCFI 119
KE++ +S + P + + +F +L+IVM Y S + +
Sbjct: 60 RKEVHIMSLIDHPNLLKAHCSFIDSSSLWIVMPYMSGGSCFHLMKSVYPEGLEQPIIATL 119
Query: 120 ILQVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTF 179
+ +V AL YLH + IHRD+KA NIL++ G V+L D GV+ + + R + NTF
Sbjct: 120 LREVLKALVYLHRQGHIHRDVKAGNILIHSKGVVKLGDFGVSACMFDSGERM--QTRNTF 177
Query: 180 VGTPFWMAPEIIKN-QSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRI-----PK 233
VGTP WMAPE+++ YD K L +G P S MK L+ P+
Sbjct: 178 VGTPCWMAPEVMQQLDGYDFK-----------YLAHGHAPFSKYPPMKVLLMTLQNAPPR 226
Query: 234 LNADSILRNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKKCSITNIMEEITVMKT 293
L+ D R+ S ++ I +CL +DP +RPT +LL+H + K T+ + +
Sbjct: 227 LDYD---RDKKFSKSFRELIAACLVKDPKKRPTAAKLLKHPFFKHARSTDYLSRKILHGL 283
Query: 294 NQI------LSKEKPRSCKPRFPLSDKVYKTNLPNQLESWRFEDESVLRFDGLGDIPN 345
+ + L + + K +++ + + +W F+ E++ R L IPN
Sbjct: 284 SPLGERFKKLKEAEAELFKGINGDKEQLSQHEYMRGISAWNFDLEALRRQASLVIIPN 341
>Hs18552621 [R] KOG0597 Serine-threonine protein kinase FUSED
Length = 1315
Score = 120 bits (302), Expect = 3e-27
Identities = 82/273 (30%), Positives = 126/273 (46%), Gaps = 19/273 (6%)
Query: 4 LQQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLK 63
++++ +LE +G+G+FG VY S Q IPK L S + + L +
Sbjct: 1 MEKYHVLEMIGEGSFGRVYKGRRKYSAQVVALKFIPK----------LGRSEKELRNLQR 50
Query: 64 EIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQV 123
EI + L P I H +F D + +V +Y +Q I Q+
Sbjct: 51 EIEIMRGLRHPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPEDQVQA-IAAQL 109
Query: 124 CHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTP 183
AL YLH R++HRD+K NILL G ++L D G + N+ L + GTP
Sbjct: 110 VSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMV-----LTSIKGTP 164
Query: 184 FWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRNM 243
+M+PE+++ + YD D+WS+G EL G PP + + I K D +
Sbjct: 165 LYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYATSIFQLVSLILK---DPVRWPS 221
Query: 244 DISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWL 276
ISP K+F++ L +DP QR + LL H ++
Sbjct: 222 TISPCFKNFLQGLLTKDPRQRLSWPDLLYHPFI 254
>At1g23700 [T] KOG0582 Ste20-like serine/threonine protein kinase
Length = 473
Score = 120 bits (302), Expect = 3e-27
Identities = 77/246 (31%), Positives = 121/246 (48%), Gaps = 9/246 (3%)
Query: 44 LAIKCINLEHSNEPIDLLLKEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEY--CSXXXX 101
+AIK NLE ++ + KE++ LS + P + + +F +L+IVM + C
Sbjct: 38 VAIKIWNLEKCTNDLETIRKEVHRLSLIDHPNLLRVHCSFIDSSSLWIVMPFMSCGSSLN 97
Query: 102 XXXXXXXXXXTEQTTCFIILQVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVT 161
E ++ ++ AL YLH IHR++KA N+L++ +G V+L D V+
Sbjct: 98 IMKSVYPNGLEEPVIAILLREILKALVYLHGLGHIHRNVKAGNVLVDSEGTVKLGDFEVS 157
Query: 162 GQLKFNSTRHGGKNLNTFVGTPFWMAPEIIKNQ--SYDGKCDIWSLGITTLELLNGKPPM 219
+ + R + NTFVG P MAPE Q YD K DIWS G+T LEL +G P
Sbjct: 158 ASMFDSVERMRTSSENTFVGNPRRMAPEKDMQQVDGYDFKVDIWSFGMTALELAHGHSPT 217
Query: 220 SHLDSMKALMRIPKLNADSILRNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKKC 279
+ L P D+ S ++ + +CL +DP +RPT QLL++ +L++
Sbjct: 218 TVLPLNLQNSPFPNYEEDT-----KFSKSFRELVAACLIEDPEKRPTASQLLEYPFLQQT 272
Query: 280 SITNIM 285
T +
Sbjct: 273 LSTEYL 278
>CE28479 [T] KOG0583 Serine/threonine protein kinase
Length = 822
Score = 120 bits (301), Expect = 5e-27
Identities = 88/271 (32%), Positives = 131/271 (47%), Gaps = 32/271 (11%)
Query: 13 VGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEH-SNEPIDLLLKEIYFLSTL 71
+GKGNF V +A + KI K +AIK I++ E + L +E+ + +
Sbjct: 22 IGKGNFATVRIARH----------KIAKT-KVAIKSIDVSALDRENLIKLEREVKIVKVI 70
Query: 72 HCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVCHALEYLH 131
P+I Y D LYIV EYCS E + A+ YLH
Sbjct: 71 DHPHIVKSYEIMRVDNMLYIVSEYCSSGELYETLIEKGRVAENVARKWFSETASAVAYLH 130
Query: 132 EKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFWMAPEII 191
+ ++HRDLKA NILL + +++ D G F++ + G + LNT+ G+P + APE++
Sbjct: 131 SQGIVHRDLKAENILLGKNSNIKIIDFG------FSNFQTGDQLLNTWCGSPPYAAPELL 184
Query: 192 KNQSYDG-KCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRNMD-----I 245
SYDG K DIWS+G+ L+ G P DS+ L R S+L + +
Sbjct: 185 LGNSYDGMKADIWSMGVLLYILVAGGFPFPS-DSVNKLKR-------SVLSGLVKIPYWV 236
Query: 246 SPLGKDFIRSCLQQDPNQRPTCKQLLQHKWL 276
S DFIR L +P +R T + +LQH+W+
Sbjct: 237 SVECADFIRKMLVLNPGKRYTIQNVLQHRWM 267
>At2g45490 [D] KOG0580 Serine/threonine protein kinase
Length = 288
Score = 120 bits (300), Expect = 6e-27
Identities = 81/276 (29%), Positives = 129/276 (46%), Gaps = 18/276 (6%)
Query: 3 SLQQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLL 62
SL F++ +GKG FG VYLA S I K I+ + H L
Sbjct: 18 SLADFEIGRPLGKGKFGRVYLAREAKSKYIVALKVIFKE---QIEKYKIHHQ------LR 68
Query: 63 KEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQ 122
+E+ ++L P I +G F + +++++EY TEQ I
Sbjct: 69 REMEIQTSLRHPNILRLFGWFHDNERIFLILEYAHGGELYGVLKQNGHLTEQQAATYIAS 128
Query: 123 VCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGT 182
+ AL Y H K +IHRD+K N+LL+ +G +++AD G + Q T GT
Sbjct: 129 LSQALAYCHGKCVIHRDIKPENLLLDHEGRLKIADFGWSVQ--------SSNKRKTMCGT 180
Query: 183 PFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRN 242
++APE+++N+ +D D W+LGI E L G PP RI K++ S
Sbjct: 181 LDYLAPEMVENRDHDYAVDNWTLGILCYEFLYGNPPFEAESQKDTFKRILKIDL-SFPLT 239
Query: 243 MDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKK 278
++S K+ I L +DP++R + ++++QH W+ K
Sbjct: 240 PNVSEEAKNLISQLLVKDPSKRLSIEKIMQHPWIVK 275
>Hs6031180 [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and related
serine/threonine protein kinases
Length = 1558
Score = 119 bits (299), Expect = 8e-27
Identities = 80/273 (29%), Positives = 129/273 (46%), Gaps = 21/273 (7%)
Query: 13 VGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLE-HSNEPIDLLLKEIYFLSTL 71
+G+G +G VY T + +A+K I + + ++ I E+ +
Sbjct: 1299 IGEGQYGKVY-----------TCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGI 1347
Query: 72 HCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVCHALEYLH 131
P + Y+G +YI MEYC E Q+ A+ LH
Sbjct: 1348 KHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQ--EHVIRLYSKQITIAINVLH 1405
Query: 132 EKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFWMAPEII 191
E ++HRD+K ANI L G ++L D G + +LK N+ G+ +N+ +GT +MAPE+I
Sbjct: 1406 EHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGE-VNSTLGTAAYMAPEVI 1464
Query: 192 ---KNQSYDGKCDIWSLGITTLELLNGKPPMSHLD-SMKALMRIPKLNADSILRNMDISP 247
K + + DIWSLG +E++ GK P + + + + ++ + I +SP
Sbjct: 1465 TRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPIPER--LSP 1522
Query: 248 LGKDFIRSCLQQDPNQRPTCKQLLQHKWLKKCS 280
GKDF+ CL+ DP R T QLL H ++K C+
Sbjct: 1523 EGKDFLSHCLESDPKMRWTASQLLDHSFVKVCT 1555
>Hs5803088 [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and related
serine/threonine protein kinases
Length = 1607
Score = 119 bits (299), Expect = 8e-27
Identities = 80/273 (29%), Positives = 129/273 (46%), Gaps = 21/273 (7%)
Query: 13 VGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLE-HSNEPIDLLLKEIYFLSTL 71
+G+G +G VY T + +A+K I + + ++ I E+ +
Sbjct: 1348 IGEGQYGKVY-----------TCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGI 1396
Query: 72 HCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVCHALEYLH 131
P + Y+G +YI MEYC E Q+ A+ LH
Sbjct: 1397 KHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRLGLQ--EHVIRLYSKQITIAINVLH 1454
Query: 132 EKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFWMAPEII 191
E ++HRD+K ANI L G ++L D G + +LK N+ G+ +N+ +GT +MAPE+I
Sbjct: 1455 EHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGE-VNSTLGTAAYMAPEVI 1513
Query: 192 ---KNQSYDGKCDIWSLGITTLELLNGKPPMSHLD-SMKALMRIPKLNADSILRNMDISP 247
K + + DIWSLG +E++ GK P + + + + ++ + I +SP
Sbjct: 1514 TRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPIPER--LSP 1571
Query: 248 LGKDFIRSCLQQDPNQRPTCKQLLQHKWLKKCS 280
GKDF+ CL+ DP R T QLL H ++K C+
Sbjct: 1572 EGKDFLSHCLESDPKMRWTASQLLDHSFVKVCT 1604
>SPBC409.07c [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 605
Score = 118 bits (296), Expect = 2e-26
Identities = 85/289 (29%), Positives = 134/289 (45%), Gaps = 34/289 (11%)
Query: 2 LSLQQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLL 61
+++ + LE +GKGN+G VY A + P V +A+K I L + +
Sbjct: 315 INMSEIIKLEELGKGNYGVVYKALHQ-----------PTGVTMALKEIRLSLEEATFNQI 363
Query: 62 LKEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTE--QTTCFI 119
+ E+ L PYI +YG F + +++I MEY T +
Sbjct: 364 IMELDILHKAVSPYIVDFYGAFFVEGSVFICMEYMDAGSMDKLYAGGIKDEGVLARTAYA 423
Query: 120 ILQVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTF 179
++Q L+ E +IHRD+K N+L+N +G+V+L D GV+G L + ++ T
Sbjct: 424 VVQGLKTLK--EEHNIIHRDVKPTNVLVNSNGQVKLCDFGVSGNLVASISK-------TN 474
Query: 180 VGTPFWMAPEIIK-------NQSYDGKCDIWSLGITTLELLNGK---PPMSHLDSMKALM 229
+G +MAPE I+ +Y + D+WSLG+T LE+ G PP S+ L
Sbjct: 475 IGCQSYMAPERIRVGGPTNGVLTYTVQADVWSLGLTILEMALGAYPYPPESYTSIFAQLS 534
Query: 230 RIPKLNADSILRNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKK 278
I + D SP +DF+ CL ++P+ RP +L H WL K
Sbjct: 535 AI--CDGDPPSLPDSFSPEARDFVNKCLNKNPSLRPDYHELANHPWLLK 581
>HsM4505103 [R] KOG0586 Serine/threonine protein kinase
Length = 713
Score = 118 bits (296), Expect = 2e-26
Identities = 81/277 (29%), Positives = 139/277 (49%), Gaps = 32/277 (11%)
Query: 7 FQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEP-IDLLLKEI 65
++LL+ +GKGNF V LA ++ + +E +AIK I+ N + L +E+
Sbjct: 56 YRLLKTIGKGNFAKVKLARHILTGRE-----------VAIKIIDKTQLNPTSLQKLFREV 104
Query: 66 YFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVCH 125
+ L+ P I + LY++MEY S E+ Q+
Sbjct: 105 RIMKILNHPNIVKLFEVIETQKTLYLIMEYASGGKVFDYLVAHGRMKEKEARSKFRQIVS 164
Query: 126 ALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFW 185
A++Y H+KR++HRDLKA N+LL+ D +++AD G + N GGK L+TF G+P +
Sbjct: 165 AVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFS-----NEFTVGGK-LDTFCGSPPY 218
Query: 186 MAPEIIKNQSYDG-KCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRNMD 244
APE+ + + YDG + D+WSLG+ L++G P ++K L + +LR
Sbjct: 219 AAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDG-QNLKEL-------RERVLRGKY 270
Query: 245 ISPL-----GKDFIRSCLQQDPNQRPTCKQLLQHKWL 276
P ++ ++ L +P +R T +Q+++ +W+
Sbjct: 271 RIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWI 307
>Hs21359873 [D] KOG0575 Polo-like serine/threonine protein kinase
Length = 603
Score = 118 bits (296), Expect = 2e-26
Identities = 74/263 (28%), Positives = 128/263 (48%), Gaps = 17/263 (6%)
Query: 13 VGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEIYFLSTLH 72
+GKG F + + + +PK++ L H E + + EI +L
Sbjct: 59 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLK------PHQREKMSM---EISIHRSLA 109
Query: 73 CPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVCHALEYLHE 132
++ ++G F + +++V+E C TE + + Q+ +YLH
Sbjct: 110 HQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHR 169
Query: 133 KRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFWMAPEIIK 192
R+IHRDLK N+ LN+D EV++ D G+ +++++ G+ T GTP ++APE++
Sbjct: 170 NRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYD-----GERKKTLCGTPNYIAPEVLS 224
Query: 193 NQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRNMDISPLGKDF 252
+ + + D+WS+G LL GKPP + +RI K N SI ++ I+P+
Sbjct: 225 KKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKK-NEYSIPKH--INPVAASL 281
Query: 253 IRSCLQQDPNQRPTCKQLLQHKW 275
I+ LQ DP RPT +LL ++
Sbjct: 282 IQKMLQTDPTARPTINELLNDEF 304
>HsM4826916 [D] KOG0575 Polo-like serine/threonine protein kinase
Length = 603
Score = 118 bits (295), Expect = 2e-26
Identities = 74/263 (28%), Positives = 128/263 (48%), Gaps = 17/263 (6%)
Query: 13 VGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEIYFLSTLH 72
+GKG F + + + +PK++ L H E + + EI +L
Sbjct: 59 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLK------PHQREKMSM---EISIHRSLA 109
Query: 73 CPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVCHALEYLHE 132
++ ++G F + +++V+E C TE + + Q+ +YLH
Sbjct: 110 HQHVVGFHGFFEDNDFVFVVLELCRRRSLLEPHKRRKALTEPEARYYLRQIVLGCQYLHR 169
Query: 133 KRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFWMAPEIIK 192
R+IHRDLK N+ LN+D EV++ D G+ +++++ G+ T GTP ++APE++
Sbjct: 170 NRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYD-----GERKKTLCGTPNYIAPEVLS 224
Query: 193 NQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRNMDISPLGKDF 252
+ + + D+WS+G LL GKPP + +RI K N SI ++ I+P+
Sbjct: 225 KKEHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKK-NEYSIPKH--INPVAASL 281
Query: 253 IRSCLQQDPNQRPTCKQLLQHKW 275
I+ LQ DP RPT +LL ++
Sbjct: 282 IQKMLQTDPTARPTINELLNDEF 304
>7297240_1 [T] KOG0587 Traf2- and Nck-interacting kinase and related germinal
center kinase (GCK) family protein kinases
Length = 326
Score = 118 bits (295), Expect = 2e-26
Identities = 80/317 (25%), Positives = 150/317 (47%), Gaps = 40/317 (12%)
Query: 6 QFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEI 65
+F++ E + +G V+ A L +++ I + ++H +E + ++E
Sbjct: 15 KFEIYEEIAQGVNAKVFRAKELDNDR--------------IVALKIQHYDEEHQVSIEEE 60
Query: 66 YFLSTLHC--PYITHYYGTF-----TGDCNLYIVMEYCSXXXXXXXXXXXXXXT----EQ 114
Y +C P + +YG + G ++ VMEYC+ E+
Sbjct: 61 YRTLRDYCDHPNLPEFYGVYKLSKPNGPDEIWFVMEYCAGGTAVDMVNKLLKLDRRMREE 120
Query: 115 TTCFIILQVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGK 174
+II + C A L+ ++HRD++ NILL +G V+L D G++ Q+ + G
Sbjct: 121 HIAYIIRETCRAAIELNRNHVLHRDIRGDNILLTKNGRVKLCDFGLSRQVDSTLGKRG-- 178
Query: 175 NLNTFVGTPFWMAPEII-----KNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALM 229
T +G+P WMAPE++ + + D+W+LGITT+EL +GKPP + + +A+
Sbjct: 179 ---TCIGSPCWMAPEVVSAMESREPDITVRADVWALGITTIELADGKPPFADMHPTRAMF 235
Query: 230 RIPKLNADSILRNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKKCSITNIMEEIT 289
+I + +++R + S DFI L+++ RP ++++H +L T ++E
Sbjct: 236 QIIRNPPPTLMRPTNWSQQINDFISESLEKNAENRPMMVEMVEHPFL-----TELIENED 290
Query: 290 VMKTNQILSKEKPRSCK 306
M+++ E R K
Sbjct: 291 EMRSDIAEMLELSRDVK 307
>CE27768 [R] KOG0586 Serine/threonine protein kinase
Length = 1096
Score = 117 bits (293), Expect = 4e-26
Identities = 80/278 (28%), Positives = 135/278 (47%), Gaps = 32/278 (11%)
Query: 6 QFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSN-EPIDLLLKE 64
+++LL+ +GKGNF V LA ++ + E +AIK I+ N + L +E
Sbjct: 121 KYKLLKTIGKGNFAKVKLAKHVITGHE-----------VAIKIIDKTALNPSSLQKLFRE 169
Query: 65 IYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVC 124
+ + L P I Y + LY+V+EY S E+ Q+
Sbjct: 170 VKIMKQLDHPNIVKLYQVMETEQTLYLVLEYASGGEVFDYLVAHGRMKEKEARAKFRQIV 229
Query: 125 HALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPF 184
A++YLH K +IHRDLKA N+LL+ D +++AD G F++T G L+TF G+P
Sbjct: 230 SAVQYLHSKNIIHRDLKAENLLLDQDMNIKIADFG------FSNTFSLGNKLDTFCGSPP 283
Query: 185 WMAPEIIKNQSYDG-KCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRNM 243
+ APE+ + YDG + D+WSLG+ L++G P ++K L + +LR
Sbjct: 284 YAAPELFSGKKYDGPEVDVWSLGVILYTLVSGSLPFDG-QNLKEL-------RERVLRGK 335
Query: 244 DISPL-----GKDFIRSCLQQDPNQRPTCKQLLQHKWL 276
P ++ ++ L +P +R + +++ +W+
Sbjct: 336 YRIPFYMSTDCENLLKKFLVINPQRRSSLDNIMKDRWM 373
>CE23838 [R] KOG0586 Serine/threonine protein kinase
Length = 1192
Score = 117 bits (293), Expect = 4e-26
Identities = 80/278 (28%), Positives = 135/278 (47%), Gaps = 32/278 (11%)
Query: 6 QFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSN-EPIDLLLKE 64
+++LL+ +GKGNF V LA ++ + E +AIK I+ N + L +E
Sbjct: 169 KYKLLKTIGKGNFAKVKLAKHVITGHE-----------VAIKIIDKTALNPSSLQKLFRE 217
Query: 65 IYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVC 124
+ + L P I Y + LY+V+EY S E+ Q+
Sbjct: 218 VKIMKQLDHPNIVKLYQVMETEQTLYLVLEYASGGEVFDYLVAHGRMKEKEARAKFRQIV 277
Query: 125 HALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPF 184
A++YLH K +IHRDLKA N+LL+ D +++AD G F++T G L+TF G+P
Sbjct: 278 SAVQYLHSKNIIHRDLKAENLLLDQDMNIKIADFG------FSNTFSLGNKLDTFCGSPP 331
Query: 185 WMAPEIIKNQSYDG-KCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRNM 243
+ APE+ + YDG + D+WSLG+ L++G P ++K L + +LR
Sbjct: 332 YAAPELFSGKKYDGPEVDVWSLGVILYTLVSGSLPFDG-QNLKEL-------RERVLRGK 383
Query: 244 DISPL-----GKDFIRSCLQQDPNQRPTCKQLLQHKWL 276
P ++ ++ L +P +R + +++ +W+
Sbjct: 384 YRIPFYMSTDCENLLKKFLVINPQRRSSLDNIMKDRWM 421
>At3g20860 [R] KOG0589 Serine/threonine protein kinase
Length = 427
Score = 117 bits (293), Expect = 4e-26
Identities = 98/337 (29%), Positives = 154/337 (45%), Gaps = 31/337 (9%)
Query: 4 LQQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLL-L 62
+ ++++E +G+G FG +L + ++ +K I L E L +
Sbjct: 12 MDDYEVVEQIGRGAFGSAFLVIHKSERRK-----------YVVKKIRLAKQTERCKLAAI 60
Query: 63 KEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXX--XTEQTTCFII 120
+E+ +S L PYI Y ++ + IV YC +E+ C +
Sbjct: 61 QEMSLISKLKSPYIVEYKDSWVEKDCVCIVTSYCEGGDMTQMIKKSRGVFASEEKLCRWM 120
Query: 121 LQVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKN--LNT 178
+Q+ A++YLH R++HRDLK +NI L + EVRL D G+ L GK+ ++
Sbjct: 121 VQLLLAIDYLHNNRVLHRDLKCSNIFLTKENEVRLGDFGLAKLL--------GKDDLASS 172
Query: 179 FVGTPFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADS 238
VGTP +M PE++ + Y K DIWSLG E+ +P D M AL I K+N S
Sbjct: 173 MVGTPNYMCPELLADIPYGYKSDIWSLGCCMFEVAAHQPAFKAPD-MAAL--INKINRSS 229
Query: 239 I--LRNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKKCSITNIMEEITVMKTNQI 296
+ L M S L K I+S L+++P RPT +LL+H L+ + V K
Sbjct: 230 LSPLPVMYSSSL-KRLIKSMLRKNPEHRPTAAELLRHPHLQP-YLAQCQNLSPVFKPVVS 287
Query: 297 LSKEKPRSCKPRFPLSDKVYKTNLPNQLESWRFEDES 333
S+ + P K KT + + ES E ++
Sbjct: 288 KSEHNTNENRTGLPPKTKSAKTPIKHNQESEETEKKN 324
>YJL128c [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 668
Score = 117 bits (292), Expect = 5e-26
Identities = 92/295 (31%), Positives = 139/295 (46%), Gaps = 42/295 (14%)
Query: 2 LSLQQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLL 61
++L + + L+ +G GN+G+V + P NV +A K + LE +
Sbjct: 355 ITLDELEFLDELGHGNYGNVSKVLHK-----------PTNVIMATKEVRLELDEAKFRQI 403
Query: 62 LKEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYC---SXXXXXXXXXXXXXXTEQTTCF 118
L E+ L + PYI +YG F + +Y+ MEY S E F
Sbjct: 404 LMELEVLHKCNSPYIVDFYGAFFIEGAVYMCMEYMDGGSLDKIYDESSEIGGIDEPQLAF 463
Query: 119 IILQVCHALEYLHEK-RLIHRDLKAANILLN-DDGEVRLADLGVTGQLKFNSTRHGGKNL 176
I V H L+ L E+ +IHRD+K NIL + + G V+L D GV+G L + +
Sbjct: 464 IANAVIHGLKELKEQHNIIHRDVKPTNILCSANQGTVKLCDFGVSGNLVASLAK------ 517
Query: 177 NTFVGTPFWMAPEIIKN-----QSYDGKCDIWSLGITTLELLNGK---PPMSHLDSMKAL 228
T +G +MAPE IK+ +Y + DIWSLG++ LE+ G+ PP ++ + L
Sbjct: 518 -TNIGCQSYMAPERIKSLNPDRATYTVQSDIWSLGLSILEMALGRYPYPPETYDNIFSQL 576
Query: 229 MRI-----PKLNADSILRNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKK 278
I P+L +D S +DF+ CLQ+ P +RPT L +H WL K
Sbjct: 577 SAIVDGPPPRLPSDK------FSSDAQDFVSLCLQKIPERRPTYAALTEHPWLVK 625
>SPAC890.03 [T] KOG0583 Serine/threonine protein kinase
Length = 672
Score = 117 bits (292), Expect = 5e-26
Identities = 84/277 (30%), Positives = 131/277 (46%), Gaps = 31/277 (11%)
Query: 7 FQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEIY 66
+++ VG+G+FG VYLA +L +N + V L C + +L +EI+
Sbjct: 31 YRIESVVGEGSFGKVYLAAHLLTNTK---------VVLKSSC------RKQAIILAREIH 75
Query: 67 FLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVCHA 126
L P IT Y + +Y+ MEYC E+TTC I+ Q+C A
Sbjct: 76 HHRRLLHPNITRLYEVVCTEDRIYLAMEYCPNGELYDWVAREKRLDEKTTCRIMWQLCCA 135
Query: 127 LEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFWM 186
++YLH + +HRDLK NI L+ V+L D G + +S +NT GT +
Sbjct: 136 IQYLHRQGCVHRDLKLENIFLDKAYNVKLGDFGFSR----DSDCSRRTFMNTRCGTVAYC 191
Query: 187 APEIIKNQSYDGKC-DIWSLGITTLELLNGKPPMSH----LDSMKALMRIPKLNADSILR 241
APE+++ Y G+C DIWSLGI LL G+ P L K + P+ +++ +
Sbjct: 192 APELVQGHKYIGECVDIWSLGIIMYALLIGRLPFDEDDVSLTEQKIINECPQY-PETLSK 250
Query: 242 NMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKK 278
N ++S L +D RP+ Q++ H + K+
Sbjct: 251 N------SSSLLKSLLCKDYRLRPSIDQIISHPYFKE 281
>CE17284 [T] KOG0583 Serine/threonine protein kinase
Length = 726
Score = 117 bits (292), Expect = 5e-26
Identities = 82/265 (30%), Positives = 125/265 (46%), Gaps = 17/265 (6%)
Query: 13 VGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEIYFLSTLH 72
+G G FG V LA +L +NQ+ +AIK I+ + + + E+ L L
Sbjct: 17 LGSGGFGKVRLATHLLTNQK-----------VAIKIIDKKQLGHDLPRVQTEMDALRNLS 65
Query: 73 CPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVCHALEYLHE 132
I Y + +IVMEYCS E Q+ A+ ++H
Sbjct: 66 HQNICRLYHYIETEDKFFIVMEYCSGGEMFDYIVRKERLEESEARHFFRQLVSAIAFVHS 125
Query: 133 KRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFWMAPEIIK 192
+ HRDLK N+LL +D ++L D G+ K R NL+T G+P + APE+I+
Sbjct: 126 QGYAHRDLKPENLLLTEDLHLKLIDFGLCA--KTEKGRIDKHNLDTCCGSPAYAAPELIQ 183
Query: 193 NQSYDG-KCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRNMDISPLGKD 251
Y G + D+WS+GI LL G P D+M+ + + K+ + +SPL K
Sbjct: 184 GLQYKGNEADVWSMGILLYTLLVGALPFED-DNMQIMYK--KIQSGCFYEPEFLSPLSKQ 240
Query: 252 FIRSCLQQDPNQRPTCKQLLQHKWL 276
+R+ LQ P +R + K+LL+H WL
Sbjct: 241 LLRAMLQVVPERRISVKKLLEHDWL 265
>Hs5730055 [D] KOG0575 Polo-like serine/threonine protein kinase
Length = 685
Score = 116 bits (291), Expect = 7e-26
Identities = 76/263 (28%), Positives = 124/263 (46%), Gaps = 21/263 (7%)
Query: 13 VGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEIYFLSTLH 72
+GKG F Y L +N+ IP + + H E ID KEI LH
Sbjct: 88 LGKGGFAKCYEMTDLTNNKVYAAKIIPHSR------VAKPHQREKID---KEIELHRILH 138
Query: 73 CPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVCHALEYLHE 132
++ +Y F N+YI++EYCS TE + + Q+ L+YLHE
Sbjct: 139 HKHVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHE 198
Query: 133 KRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFWMAPEIIK 192
+ ++HRDLK N +N+ E+++ D G+ +L+ R T GTP +++PE++
Sbjct: 199 QEILHRDLKLGNFFINEAMELKVGDFGLAARLEPLEHRR-----RTICGTPNYLSPEVLN 253
Query: 193 NQSYDGKCDIWSLGITTLELLNGKPPM--SHLDSMKALMRIPKLNADSILRNMDISPLGK 250
Q + + DIW+LG +L G+PP ++L +R + S L ++P K
Sbjct: 254 KQGHGCESDIWALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMPSSL----LAP-AK 308
Query: 251 DFIRSCLQQDPNQRPTCKQLLQH 273
I S L ++P RP+ +++H
Sbjct: 309 HLIASMLSKNPEDRPSLDDIIRH 331
>At4g32830 [D] KOG0580 Serine/threonine protein kinase
Length = 294
Score = 116 bits (291), Expect = 7e-26
Identities = 83/278 (29%), Positives = 131/278 (46%), Gaps = 26/278 (9%)
Query: 3 SLQQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLL 62
+L F + + +G+G FG VYLA SN + K+ ++ +EH L
Sbjct: 27 TLSDFDIGKPLGRGKFGHVYLAREKRSNHVVALKVLFKS---QLQQSQVEHQ------LR 77
Query: 63 KEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQ 122
+E+ S L P I YG F +Y+++EY + +E+ +
Sbjct: 78 REVEIQSHLRHPNILRLYGYFYDQKRVYLILEYAARGELYKDLQKCKYFSERRAATYVAS 137
Query: 123 VCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGT 182
+ AL Y H K +IHRD+K N+L+ GE+++AD G + FN R T GT
Sbjct: 138 LARALIYCHGKHVIHRDIKPENLLIGAQGELKIADFGWSVH-TFNRRR-------TMCGT 189
Query: 183 PFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPP---MSHLDSMKALMRIP-KLNADS 238
++ PE++++ +D DIWSLGI E L G PP M H D+ + ++++ K
Sbjct: 190 LDYLPPEMVESVEHDASVDIWSLGILCYEFLYGVPPFEAMEHSDTYRRIVQVDLKFPPKP 249
Query: 239 ILRNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWL 276
I IS KD I L ++ +QR +LL+H W+
Sbjct: 250 I-----ISASAKDLISQMLVKESSQRLPLHKLLEHPWI 282
>7299160 [OUT] KOG0595 Serine/threonine-protein kinase involved in autophagy
Length = 520
Score = 116 bits (291), Expect = 7e-26
Identities = 81/277 (29%), Positives = 124/277 (44%), Gaps = 21/277 (7%)
Query: 4 LQQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEH-SNEPIDLLL 62
+ F++LE +G G++ VY A + + AIK + + S + L+
Sbjct: 6 ITDFEILEKLGAGSYATVYKARHK-----------KQRTYHAIKYVEMSTLSQTSRENLI 54
Query: 63 KEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQ 122
EI L L YI F D N+YIV+EYC+ E T + + Q
Sbjct: 55 TEIRLLRELKHKYIVTLQDFFWDDKNIYIVLEYCNAGNLSAFIRTKKALPESTCRYFLRQ 114
Query: 123 VCHALEYLHEKRLIHRDLKAANILLN---DDGEVRLADLGVTGQLKFNSTRHGGKNLNTF 179
+ A++Y+ + H DLK N+LL ++ +++AD G LK K
Sbjct: 115 LAAAVQYMRANDVSHFDLKPQNLLLTRGANNVSLKVADFGFAQHLKLGEINQQLK----- 169
Query: 180 VGTPFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSI 239
G+P +MAPEI++ YD K D+WS+G+ E L GK P S + L+RI K A ++
Sbjct: 170 -GSPLYMAPEIVRKHQYDAKADLWSIGVILYECLFGKAPYSSRTIEELLLRIRKAEAITL 228
Query: 240 LRNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWL 276
N IS D +R L +P R + H +L
Sbjct: 229 PPNARISNECHDLLRRLLAHEPTARISFADFFAHPFL 265
>7296166 [T] KOG0614 cGMP-dependent protein kinase
Length = 768
Score = 116 bits (291), Expect = 7e-26
Identities = 84/281 (29%), Positives = 129/281 (45%), Gaps = 23/281 (8%)
Query: 2 LSLQQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEH--SNEPID 59
L L +++ +G G FG V L +Q+ D A+KC+ H + +
Sbjct: 452 LKLTDLEVVSTLGIGGFGRVELVK--AHHQDRVDI-------FALKCLKKRHIVDTKQEE 502
Query: 60 LLLKEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFI 119
+ E + + + P+I Y TF + +Y+++E C + FI
Sbjct: 503 HIFSERHIMLSSRSPFICRLYRTFRDEKYVYMLLEACMGGEIWTMLRDRGSFEDNAAQFI 562
Query: 120 ILQVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTF 179
I V A EYLH + +I+RDLK N++L++ G V++ D G Q+ +S TF
Sbjct: 563 IGCVLQAFEYLHARGIIYRDLKPENLMLDERGYVKIVDFGFAKQIGTSSKTW------TF 616
Query: 180 VGTPFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSI 239
GTP ++APEII N+ +D D W+LGI ELLNG PP S D M+ I K D I
Sbjct: 617 CGTPEYVAPEIILNKGHDRAVDYWALGILIHELLNGTPPFSAPDPMQTYNLILK-GIDMI 675
Query: 240 LRNMDISPLGKDFIRSCLQQDPNQR-----PTCKQLLQHKW 275
IS I+ + P++R + + +HKW
Sbjct: 676 AFPKHISRWAVQLIKRLCRDVPSERLGYQTGGIQDIKKHKW 716
>SPBC543.07 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 363
Score = 115 bits (289), Expect = 1e-25
Identities = 76/231 (32%), Positives = 111/231 (47%), Gaps = 22/231 (9%)
Query: 61 LLKEIYFLSTLHCPYITHYYGTF--TGDCNLYIVMEYCSXXXXXXXXXXXXX----XTEQ 114
LL+E+ + PYI YYG +C L I MEYC E+
Sbjct: 122 LLRELKINRSCTSPYIVKYYGACYNNAECQLNIAMEYCGAGSLDAIYKRVRSQGGRTGER 181
Query: 115 TTCFIILQVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGK 174
I V L YLH++++IHRD+K +NILL G+V+L D GV+G+L NS
Sbjct: 182 PLGKIAFGVLSGLSYLHDRKIIHRDIKPSNILLTSKGQVKLCDFGVSGEL-VNSL----- 235
Query: 175 NLNTFVGTPFWMAPEIIKNQSYDGKCDIWSLGITTLELL--------NGKPPMSHLDSMK 226
TF GT ++MAPE I SY DIWSLG+T +E+ G PP ++ +
Sbjct: 236 -AGTFTGTSYYMAPERISGGSYTISSDIWSLGLTLMEVALNRFPFPPEGSPPPMPIELLS 294
Query: 227 ALMRIPKLNADSILRNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLK 277
++ +P + S + F+ CL +D +RP +++L H W+K
Sbjct: 295 YIINMPPPLLPQ-EPGIKWSKSFQHFLCVCLDKDKTRRPGPQKMLTHPWVK 344
>Hs5453976 [T] KOG0694 Serine/threonine protein kinase
Length = 706
Score = 115 bits (289), Expect = 1e-25
Identities = 72/225 (32%), Positives = 112/225 (49%), Gaps = 19/225 (8%)
Query: 2 LSLQQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLA---IKCINLEHSNEPI 58
L ++ F L + +GKG+FG V+LA + +NQ + K+V L ++C +E
Sbjct: 375 LKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVE------ 428
Query: 59 DLLLKEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCF 118
K + L+ H P++TH + TF NL+ VMEY + F
Sbjct: 429 ----KRVLSLAWEH-PFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATF 483
Query: 119 IILQVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNT 178
++ L++LH K +++RDLK NILL+ DG +++AD G+ + G NT
Sbjct: 484 YAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENML-----GDAKTNT 538
Query: 179 FVGTPFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLD 223
F GTP ++APEI+ Q Y+ D WS G+ E+L G+ P D
Sbjct: 539 FCGTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQD 583
>Hs13899225 [R] KOG0586 Serine/threonine protein kinase
Length = 688
Score = 115 bits (289), Expect = 1e-25
Identities = 79/277 (28%), Positives = 133/277 (47%), Gaps = 32/277 (11%)
Query: 7 FQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSN-EPIDLLLKEI 65
++LL +GKGN V LA ++ + +E +AIK I+ N + L +E+
Sbjct: 59 YRLLRTIGKGNSAKVKLARHILTGRE-----------VAIKIIDKTQLNPSSLQKLFREV 107
Query: 66 YFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVCH 125
+ L+ P I + + LY+VMEY S E+ Q+
Sbjct: 108 RIMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVS 167
Query: 126 ALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFW 185
A+ Y H+K ++HRDLKA N+LL+ + +++AD G + + G L+TF G+P +
Sbjct: 168 AVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTL------GSKLDTFCGSPPY 221
Query: 186 MAPEIIKNQSYDG-KCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRNMD 244
APE+ + + YDG + DIWSLG+ L++G P ++K L + +LR
Sbjct: 222 AAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDG-HNLKEL-------RERVLRGKY 273
Query: 245 ISPL-----GKDFIRSCLQQDPNQRPTCKQLLQHKWL 276
P + +R L +P +R T +Q+++ KW+
Sbjct: 274 RVPFYMSTDCESILRRFLVLNPAKRCTLEQIMKDKWI 310
>7302464 [R] KOG0586 Serine/threonine protein kinase
Length = 739
Score = 115 bits (289), Expect = 1e-25
Identities = 78/275 (28%), Positives = 136/275 (49%), Gaps = 26/275 (9%)
Query: 6 QFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNE-PIDLLLKE 64
+++L++ +GKGNF V LA +L + +E +AIK I+ N + L +E
Sbjct: 150 KYKLIKTIGKGNFAKVKLAKHLPTGKE-----------VAIKIIDKTQLNPGSLQKLFRE 198
Query: 65 IYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVC 124
+ + L P I + + LY++MEY S E+ Q+
Sbjct: 199 VRIMKMLDHPNIVKLFQVIETEKTLYLIMEYASGGEVFDYLVLHGRMKEKEARVKFRQIV 258
Query: 125 HALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPF 184
A++Y H+KR+IHRDLKA N+LL+ + +++AD G F++ G L+TF G+P
Sbjct: 259 SAVQYCHQKRIIHRDLKAENLLLDSELNIKIADFG------FSNEFTPGSKLDTFCGSPP 312
Query: 185 WMAPEIIKNQSYDG-KCDIWSLGITTLELLNGKPPM--SHLDSMKALMRIPKLNADSILR 241
+ APE+ + + YDG + D+WSLG+ L++G P S L ++ + K +
Sbjct: 313 YAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGSTLRELRERVLRGKYRIPFYM- 371
Query: 242 NMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWL 276
S ++ +R L +P +R + + ++ KW+
Sbjct: 372 ----STDCENLLRKFLVLNPAKRASLETIMGDKWM 402
>7292679 [G] KOG0599 Phosphorylase kinase gamma subunit
Length = 560
Score = 115 bits (289), Expect = 1e-25
Identities = 70/212 (33%), Positives = 103/212 (48%), Gaps = 13/212 (6%)
Query: 74 PYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVCHALEYLHEK 133
PYI F D +++V E C +E+ T I+ Q+ +EY+H K
Sbjct: 88 PYIIDLQDVFESDAFVFLVFELCPKGELFDYLTSVVTLSEKKTRTIMRQIFEGVEYIHAK 147
Query: 134 RLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFWMAPEIIKN 193
++HRDLK NILL+++ V++ D G QL+ G+ L GTP ++APE +K
Sbjct: 148 SIVHRDLKPENILLDENHNVKITDFGFAKQLQ------EGEKLTNLCGTPGYLAPETLKC 201
Query: 194 QSYDG------KCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRN-MDIS 246
++G + DIW+ G+ LL G PP H M L I + DIS
Sbjct: 202 NMFEGSPGYSQEVDIWACGVIMFTLLVGCPPFWHRKQMVMLRNIMEGKYSFTSPEWADIS 261
Query: 247 PLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKK 278
KD IR CL DP+QR T K++L+H + +
Sbjct: 262 EDPKDLIRKCLVVDPSQRITVKEVLRHPFFNQ 293
>7291037 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 396
Score = 115 bits (289), Expect = 1e-25
Identities = 94/332 (28%), Positives = 147/332 (43%), Gaps = 44/332 (13%)
Query: 2 LSLQQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLL 61
LS + + L +G GN G V + ++ + +A K I+LE +
Sbjct: 82 LSDEDLEKLGELGSGNGGVVMKVRHTHTH-----------LIMARKLIHLEVKPAIKKQI 130
Query: 62 LKEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIIL 121
L+E+ L + P+I +YG F D + I MEY E I L
Sbjct: 131 LRELKVLHECNFPHIVGFYGAFYSDGEISICMEYMDGGSLDLILKRAGRIPESILGRITL 190
Query: 122 QVCHALEYLHEKR-LIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFV 180
V L YL + +IHRD+K +NIL+N GE+++ D GV+GQL + N+FV
Sbjct: 191 AVLKGLSYLRDNHAIIHRDVKPSNILVNSSGEIKICDFGVSGQLIDSMA-------NSFV 243
Query: 181 GTPFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPM-----SHLDSMKA-------- 227
GT +M+PE ++ Y + DIWSLG++ +E+ G P+ + L+S+ A
Sbjct: 244 GTRSYMSPERLQGTHYSVQSDIWSLGLSLVEMAIGMYPIPPPNTATLESIFADNAEESGQ 303
Query: 228 ------LMRIPKL------NADSILRNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKW 275
M I +L L + S KDF+ CL++ P++R K LL H W
Sbjct: 304 PTDEPRAMAIFELLDYIVNEPPPKLEHKIFSTEFKDFVDICLKKQPDERADLKTLLSHPW 363
Query: 276 LKKCSITNIMEEITVMKTNQILSKEKPRSCKP 307
++K + + V KT + R+ P
Sbjct: 364 IRKAELEEVDISGWVCKTMDLPPSTPKRNTSP 395
>Hs13569922 [R] KOG0611 Predicted serine/threonine protein kinase
Length = 628
Score = 115 bits (288), Expect = 1e-25
Identities = 80/285 (28%), Positives = 131/285 (45%), Gaps = 25/285 (8%)
Query: 6 QFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLL--LK 63
+++ LE +GKG +G V A +AIK I + + DL+ +
Sbjct: 52 RYEFLETLGKGTYGKVKKARESSGRL------------VAIKSIRKDKIKDEQDLMHIRR 99
Query: 64 EIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQV 123
EI +S+L+ P+I + F + IVMEY S +E+ Q+
Sbjct: 100 EIEIMSSLNHPHIIAIHEVFENSSKIVIVMEYASRGDLYDYISERQQLSEREARHFFRQI 159
Query: 124 CHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTP 183
A+ Y H+ R++HRDLK NILL+ +G +++AD G+ ++ H GK L TF G+P
Sbjct: 160 VSAVHYCHQNRVVHRDLKLENILLDANGNIKIADFGL------SNLYHQGKFLQTFCGSP 213
Query: 184 FWMAPEIIKNQSYDG-KCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRN 242
+ +PEI+ + Y G + D WSLG+ L++G P D + +I ++ R
Sbjct: 214 LYASPEIVNGKPYTGPEVDSWSLGVLLYILVHGTMPFDGHDHKILVKQI----SNGAYRE 269
Query: 243 MDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKKCSITNIMEE 287
IR L +P +R T + + H W+ T + E+
Sbjct: 270 PPKPSDACGLIRWLLMVNPTRRATLEDVASHWWVNWGYATRVGEQ 314
>SPBC106.10 [T] KOG0616 cAMP-dependent protein kinase catalytic subunit (PKA)
Length = 512
Score = 115 bits (287), Expect = 2e-25
Identities = 85/289 (29%), Positives = 131/289 (44%), Gaps = 28/289 (9%)
Query: 4 LQQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLK 63
+Q F L+ +G G+FG V+L + + K + +K +EH+ +
Sbjct: 198 IQDFNFLQTLGTGSFGRVHLVQSNHNRLYYAIKVLEKKKIVDMK--QIEHTCD------- 248
Query: 64 EIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQV 123
E Y LS + P+IT +GTF NL++VM++ E+ F +V
Sbjct: 249 ERYILSRVQHPFITILWGTFQDAKNLFMVMDFAEGGELFSLLRKCHRFPEKVAKFYAAEV 308
Query: 124 CHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTP 183
AL+YLH ++++RDLK N+LL+ G +++ D G + R N T GTP
Sbjct: 309 ILALDYLHHNQIVYRDLKPENLLLDRFGHLKIVDFGF-------AKRVSTSNCCTLCGTP 361
Query: 184 FWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRI--PKLNADSILR 241
++APEII + Y+ D WSLGI E+L G PP + MK I K+N S
Sbjct: 362 DYLAPEIISLKPYNKAADWWSLGILIFEMLAGYPPFYSENPMKLYENILEGKVNYPSY-- 419
Query: 242 NMDISPLGKDFIRSCLQQD-----PNQRPTCKQLLQHKWLKKCSITNIM 285
SP D + LQ+D N + ++ H W + S I+
Sbjct: 420 ---FSPASIDLLSHLLQRDITCRYGNLKDGSMDIIMHPWFRDISWDKIL 465
>Hs4507277_1 [R] KOG0589 Serine/threonine protein kinase
Length = 292
Score = 114 bits (286), Expect = 2e-25
Identities = 87/310 (28%), Positives = 145/310 (46%), Gaps = 24/310 (7%)
Query: 2 LSLQQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEH-SNEPIDL 60
+ L + L VGKG++G+V L + ++ IK +NL + S+
Sbjct: 1 MPLAAYCYLRVVGKGSYGEVTLVKHRRDGKQ-----------YVIKKLNLRNASSRERRA 49
Query: 61 LLKEIYFLSTLHCPYITHYYGTFTG-DCNLYIVMEYCSXXXXXXXXXXXXXXT--EQTTC 117
+E LS L P I Y ++ G D LYIVM +C E
Sbjct: 50 AEQEAQLLSQLKHPNIVTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPENQVV 109
Query: 118 FIILQVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLN 177
+Q+ AL+YLHEK ++HRDLK N+ L +++ DLG+ L+ + +
Sbjct: 110 EWFVQIAMALQYLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDM-----AS 164
Query: 178 TFVGTPFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNAD 237
T +GTP++M+PE+ N+ Y+ K D+W+LG E+ K + D + RI +
Sbjct: 165 TLIGTPYYMSPELFSNKPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLP 224
Query: 238 SILRNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKKCSITNIMEEITVMKTNQIL 297
++ R D SP + IR+ L + P +RP+ + +L+ ++K+ + E T +KT++
Sbjct: 225 AMPR--DYSPELAELIRTMLSKRPEERPSVRSILRQPYIKR--QISFFLEATKIKTSKNN 280
Query: 298 SKEKPRSCKP 307
K KP
Sbjct: 281 IKNGDSQSKP 290
>7293666 [D] KOG0575 Polo-like serine/threonine protein kinase
Length = 576
Score = 114 bits (285), Expect = 3e-25
Identities = 73/253 (28%), Positives = 115/253 (44%), Gaps = 12/253 (4%)
Query: 63 KEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQ 122
+EI +L+ P I ++ F N+YIV+E C TE + I Q
Sbjct: 72 QEITIHRSLNHPNIVKFHNYFEDSQNIYIVLELCKKRSMMELHKRRKSITEFECRYYIYQ 131
Query: 123 VCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGT 182
+ ++YLH+ R+IHRDLK N+ LND V++ D G+ ++++ G+ T GT
Sbjct: 132 IIQGVKYLHDNRIIHRDLKLGNLFLNDLLHVKIGDFGLATRIEYE-----GERKKTLCGT 186
Query: 183 PFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPK--LNADSIL 240
P ++APEI+ + + + DIWS+G LL G+PP +I K S L
Sbjct: 187 PNYIAPEILTKKGHSFEVDIWSIGCVMYTLLVGQPPFETKTLKDTYSKIKKCEYRVPSYL 246
Query: 241 RNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKKCSITNIMEEITVMKTNQILSKE 300
R D + + LQ +P RP QLL ++LK + + + +I S +
Sbjct: 247 RKP-----AADMVIAMLQPNPESRPAIGQLLNFEFLKGSKVPMFLPSSCLTMAPRIGSND 301
Query: 301 KPRSCKPRFPLSD 313
R PL +
Sbjct: 302 TIEDSMHRKPLME 314
>CE17354 [T] KOG0694 Serine/threonine protein kinase
Length = 567
Score = 114 bits (284), Expect = 4e-25
Identities = 72/216 (33%), Positives = 106/216 (48%), Gaps = 12/216 (5%)
Query: 3 SLQQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLL 62
+L F LL+ +GKG+FG V L G N+ + K+V L + + +L
Sbjct: 234 ALPHFNLLKVLGKGSFGKVMLVELKGKNEFYAMKCLKKDVILEDDDTECTYIERRVLILA 293
Query: 63 KEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQ 122
+ FL L C + T+ Y L+ VMEY + E T F +
Sbjct: 294 SQCPFLCQLFCSFQTNEY--------LFFVMEYLNGGDLMHHIQQIKKFDEARTRFYACE 345
Query: 123 VCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGT 182
+ AL++LH +I+RDLK N+LL+ DG ++LAD G+ K R G +TF GT
Sbjct: 346 IVVALQFLHTNNIIYRDLKLDNVLLDCDGHIKLADFGMA---KTEMNRENGM-ASTFCGT 401
Query: 183 PFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPP 218
P +++PEIIK Q Y+ D WS G+ E+L G+ P
Sbjct: 402 PDYISPEIIKGQLYNEAVDFWSFGVLMYEMLVGQSP 437
>CE17353 [T] KOG0694 Serine/threonine protein kinase
Length = 704
Score = 114 bits (284), Expect = 4e-25
Identities = 72/216 (33%), Positives = 106/216 (48%), Gaps = 12/216 (5%)
Query: 3 SLQQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLL 62
+L F LL+ +GKG+FG V L G N+ + K+V L + + +L
Sbjct: 371 ALPHFNLLKVLGKGSFGKVMLVELKGKNEFYAMKCLKKDVILEDDDTECTYIERRVLILA 430
Query: 63 KEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQ 122
+ FL L C + T+ Y L+ VMEY + E T F +
Sbjct: 431 SQCPFLCQLFCSFQTNEY--------LFFVMEYLNGGDLMHHIQQIKKFDEARTRFYACE 482
Query: 123 VCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGT 182
+ AL++LH +I+RDLK N+LL+ DG ++LAD G+ K R G +TF GT
Sbjct: 483 IVVALQFLHTNNIIYRDLKLDNVLLDCDGHIKLADFGMA---KTEMNRENGM-ASTFCGT 538
Query: 183 PFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPP 218
P +++PEIIK Q Y+ D WS G+ E+L G+ P
Sbjct: 539 PDYISPEIIKGQLYNEAVDFWSFGVLMYEMLVGQSP 574
>Hs9966875 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 357
Score = 113 bits (283), Expect = 6e-25
Identities = 81/275 (29%), Positives = 129/275 (46%), Gaps = 23/275 (8%)
Query: 7 FQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEIY 66
F+ E +G G F +V LA +E K+ A+KCI + + EI
Sbjct: 23 FEFKETLGTGAFSEVVLA------EEKATGKL-----FAVKCIPKKALKGKESSIENEIA 71
Query: 67 FLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVCHA 126
L + I + +LY+VM+ S TE+ +I QV A
Sbjct: 72 VLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDA 131
Query: 127 LEYLHEKRLIHRDLKAANILL---NDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTP 183
+ YLH ++HRDLK N+L +++ ++ ++D G++ G ++T GTP
Sbjct: 132 VYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLS------KMEGKGDVMSTACGTP 185
Query: 184 FWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNA--DSILR 241
++APE++ + Y D WS+G+ LL G PP + K +I K DS
Sbjct: 186 GYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYW 245
Query: 242 NMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWL 276
+ DIS KDFIR+ +++DPN+R TC+Q +H W+
Sbjct: 246 D-DISDSAKDFIRNLMEKDPNKRYTCEQAARHPWI 279
>Hs8923922 [R] KOG0586 Serine/threonine protein kinase
Length = 795
Score = 113 bits (283), Expect = 6e-25
Identities = 75/277 (27%), Positives = 136/277 (49%), Gaps = 32/277 (11%)
Query: 7 FQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEP-IDLLLKEI 65
++L + +GKGNF V LA ++ + +E +A+K I+ N + L +E+
Sbjct: 60 YRLQKTIGKGNFAKVKLARHVLTGRE-----------VAVKIIDKTQLNPTSLQKLFREV 108
Query: 66 YFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVCH 125
+ L+ P I + + LY+VMEY S E+ Q+
Sbjct: 109 RIMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVS 168
Query: 126 ALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFW 185
A++Y H+K ++HRDLKA N+LL+ D +++AD G + + G L+TF G+P +
Sbjct: 169 AVQYCHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTV------GNKLDTFCGSPPY 222
Query: 186 MAPEIIKNQSYDG-KCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRNMD 244
APE+ + + YDG + D+WSLG+ L++G P ++K L + +LR
Sbjct: 223 AAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDG-QNLKEL-------RERVLRGKY 274
Query: 245 ISPL-----GKDFIRSCLQQDPNQRPTCKQLLQHKWL 276
P ++ ++ L +P +R + +Q+++ +W+
Sbjct: 275 RIPFYMSTDCENLLKKLLVLNPIKRGSLEQIMKDRWM 311
>At1g79640 [T] KOG0582 Ste20-like serine/threonine protein kinase
Length = 547
Score = 113 bits (283), Expect = 6e-25
Identities = 77/243 (31%), Positives = 112/243 (45%), Gaps = 39/243 (16%)
Query: 38 IPKNVPLAIKCINLEHSNEPIDLLLKEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCS 97
IP + +AIK ++ E N ++ + +E + + P + + +F D NL+++M Y S
Sbjct: 33 IPFDEVVAIKILDFERDNCDLNNISREAQTMMLVDHPNVLKSHCSFVSDHNLWVIMPYMS 92
Query: 98 XXXXXXXXXXXX--XXTEQTTCFIILQVCHALEYLHEKRLIHRDLKAANILLNDDGEVRL 155
E I+ + L+YLH+ IHRD+KA NILL G V+L
Sbjct: 93 GGSCLHILKAAYPDGFEEAIIATILREALKGLDYLHQHGHIHRDVKAGNILLGARGAVKL 152
Query: 156 ADLGVTGQLKFNSTRHGGKNLNTFVGTPFWMAPEIIKNQSYDGKCDIWSLGITTLELLNG 215
D GV+ L + R + NTFVGTP W DIWS GIT LEL +G
Sbjct: 153 GDFGVSACLFDSGDRQ--RTRNTFVGTPCW--------------ADIWSFGITGLELAHG 196
Query: 216 KPPMSHLDSMKALMRIPKLNADSILRNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKW 275
P S MK+ K I SCL +DP++RP+ K+LL+H +
Sbjct: 197 HAPFSKYPPMKSF---------------------KQMIASCLVKDPSKRPSAKKLLKHSF 235
Query: 276 LKK 278
K+
Sbjct: 236 FKQ 238
>Hs4759178 [D] KOG0580 Serine/threonine protein kinase
Length = 344
Score = 113 bits (282), Expect = 7e-25
Identities = 80/281 (28%), Positives = 130/281 (45%), Gaps = 31/281 (11%)
Query: 3 SLQQFQLLECVGKGNFGDVYLA-----HYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEP 57
++ F++ +GKG FG+VYLA H++ + + +I K +EH
Sbjct: 73 TIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKE--------GVEHQ--- 121
Query: 58 IDLLLKEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTC 117
L +EI + LH P I Y F +Y+++EY EQ T
Sbjct: 122 ---LRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTA 178
Query: 118 FIILQVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLN 177
I+ ++ AL Y H K++IHRD+K N+LL GE+++AD G S
Sbjct: 179 TIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGW-------SVHAPSLRRK 231
Query: 178 TFVGTPFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNAD 237
T GT ++ PE+I+ + ++ K D+W +G+ ELL G PP + RI K++
Sbjct: 232 TMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVD-- 289
Query: 238 SILRNMDISPLG-KDFIRSCLQQDPNQRPTCKQLLQHKWLK 277
L+ P G +D I L+ +P++R Q+ H W++
Sbjct: 290 --LKFPASVPTGAQDLISKLLRHNPSERLPLAQVSAHPWVR 328
>At1g50230 [R] KOG0597 Serine-threonine protein kinase FUSED
Length = 269
Score = 113 bits (282), Expect = 7e-25
Identities = 81/278 (29%), Positives = 133/278 (47%), Gaps = 21/278 (7%)
Query: 2 LSLQQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLE-HSNEPIDL 60
+ ++ + ++E VG+G+FG VY + Q +A+K I + +++ I
Sbjct: 1 MGVEDYHVIELVGEGSFGRVYKGRRKYTGQT-----------VAMKFIMKQGKTDKDIHS 49
Query: 61 LLKEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFII 120
L +EI L L I +F +V E+ EQ I
Sbjct: 50 LRQEIEILRKLKHENIIEMLDSFENAREFCVVTEFAQGELFEILEDDKCLPEEQVQA-IA 108
Query: 121 LQVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFV 180
Q+ AL+YLH R+IHRD+K NIL+ V+L D G + N+ L +
Sbjct: 109 KQLVKALDYLHSNRIIHRDMKPQNILIGAGSVVKLCDFGFARAMSTNTVV-----LRSIK 163
Query: 181 GTPFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSIL 240
GTP +MAPE++K Q YD D+WSLG+ EL G+PP + +S+ AL+R + D +
Sbjct: 164 GTPLYMAPELVKEQPYDRTVDLWSLGVILYELYVGQPPF-YTNSVYALIR--HIVKDPVK 220
Query: 241 RNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKK 278
++S + F++ L ++P+ R T L +H ++K+
Sbjct: 221 YPDEMSTYFESFLKGLLNKEPHSRLTWPALREHPFVKE 258
>At3g08730 [RT] KOG0598 Ribosomal protein S6 kinase and related proteins
Length = 465
Score = 112 bits (281), Expect = 9e-25
Identities = 78/284 (27%), Positives = 132/284 (46%), Gaps = 28/284 (9%)
Query: 1 MLSLQQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEP--I 58
++ + F++++ VGKG FG VY K + A+K + +H E
Sbjct: 128 VVGIDDFEVMKVVGKGAFGKVYQVR-----------KKETSEIYAMKVMRKDHIMEKNHA 176
Query: 59 DLLLKEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCF 118
+ + E L+ + P+I +F LY+V+++ + E
Sbjct: 177 EYMKAERDILTKIDHPFIVQLKYSFQTKYRLYLVLDFINGGHLFFQLYHQGLFREDLARV 236
Query: 119 IILQVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNT 178
++ A+ +LHEK ++HRDLK NIL++ DG V L D G+ + + N+ N+
Sbjct: 237 YTAEIVSAVSHLHEKGIMHRDLKPENILMDTDGHVMLTDFGLAKEFEENTRS------NS 290
Query: 179 FVGTPFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADS 238
GT +MAPEI++ + +D D WS+GI E+L GKPP L S + + K+ D
Sbjct: 291 MCGTTEYMAPEIVRGKGHDKAADWWSVGILLYEMLTGKPPF--LGSKGKIQQ--KIVKDK 346
Query: 239 ILRNMDISPLGKDFIRSCLQQDPNQR-----PTCKQLLQHKWLK 277
I +S ++ LQ++P +R +++ QHKW K
Sbjct: 347 IKLPQFLSNEAHAILKGLLQKEPERRLGSGLSGAEEIKQHKWFK 390
>Hs4885563 [T] KOG0694 Serine/threonine protein kinase
Length = 737
Score = 112 bits (280), Expect = 1e-24
Identities = 79/268 (29%), Positives = 129/268 (47%), Gaps = 20/268 (7%)
Query: 2 LSLQQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLL 61
L L +F ++ +GKG+FG V LA G ++ + K+V L ++ +D
Sbjct: 403 LGLDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVIL---------QDDDVDCT 453
Query: 62 L--KEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFI 119
+ K I L+ H PY+T Y F L+ VMEY + E + F
Sbjct: 454 MTEKRILALARKH-PYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFY 512
Query: 120 ILQVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTF 179
+V AL +LH+ +I+RDLK NILL+ +G +LAD G+ + N G TF
Sbjct: 513 AAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILN-----GVTTTTF 567
Query: 180 VGTPFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSI 239
GTP ++APEI++ Y D W+LG+ E++ G+PP D+ L + D +
Sbjct: 568 CGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPF-EADNEDDLFE--SILHDDV 624
Query: 240 LRNMDISPLGKDFIRSCLQQDPNQRPTC 267
L + +S +++ + ++P++R C
Sbjct: 625 LYPVWLSKEAVSILKAFMTKNPHKRLGC 652
>At4g26890 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 444
Score = 112 bits (280), Expect = 1e-24
Identities = 75/237 (31%), Positives = 121/237 (50%), Gaps = 19/237 (8%)
Query: 45 AIKCINLEHSNEPIDLLLKEIYFLSTLHCPYITHYYGT-FTGDCN---LYIVMEYCSXXX 100
A+K +L S+ LL KE LSTL P++ Y GT T + N I+MEY S
Sbjct: 31 AVKSADLSSSS----LLQKEQSILSTLSSPHMVKYIGTGLTRESNGLVYNILMEYVSGGN 86
Query: 101 XXXXXXXXXXXT-EQTTCFIILQVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLG 159
E Q+ + L YLHE+ ++H DLK+ N+L+ ++G +++AD+G
Sbjct: 87 LHDLIKNSGGKLPEPEIRSYTRQILNGLVYLHERGIVHCDLKSHNVLVEENGVLKIADMG 146
Query: 160 VTGQLKFNSTRHGGKNLNTFVGTPFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPM 219
+ + + F GTP +MAPE+ + + D+W+LG T +E++ G P
Sbjct: 147 CAKSV----------DKSEFSGTPAFMAPEVARGEEQRFPADVWALGCTMIEMMTGSSPW 196
Query: 220 SHLDSMKALMRIPKLNADSILRNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWL 276
L+ + A M + +S IS KDF+++CL++D QR T ++LL+H +L
Sbjct: 197 PELNDVVAAMYKIGFSGESPAIPAWISDKAKDFLKNCLKEDQKQRWTVEELLKHPFL 253
>YJL164c [T] KOG0616 cAMP-dependent protein kinase catalytic subunit (PKA)
Length = 397
Score = 112 bits (279), Expect = 2e-24
Identities = 81/280 (28%), Positives = 130/280 (45%), Gaps = 27/280 (9%)
Query: 5 QQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKE 64
+ FQ+L +G G+FG V+L + + + K + + +K +EH+N+ E
Sbjct: 85 KNFQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLK--QVEHTND-------E 135
Query: 65 IYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVC 124
LS + P+I +GTF ++++M+Y F +VC
Sbjct: 136 RLMLSIVTHPFIIRMWGTFQDAQQIFMIMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVC 195
Query: 125 HALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPF 184
ALEYLH K +I+RDLK NILL+ +G +++ D G ++ T GTP
Sbjct: 196 LALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGF--------AKYVPDVTYTLCGTPD 247
Query: 185 WMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILR--- 241
++APE++ + Y+ D WS GI E+L G P ++MK +I LNA+ LR
Sbjct: 248 YIAPEVVSTKPYNKSIDWWSFGILIYEMLAGYTPFYDSNTMKTYEKI--LNAE--LRFPP 303
Query: 242 --NMDISPLGKDFI-RSCLQQDPNQRPTCKQLLQHKWLKK 278
N D+ L I R Q+ N + + + H W K+
Sbjct: 304 FFNEDVKDLLSRLITRDLSQRLGNLQNGTEDVKNHPWFKE 343
>ECU07g0360 [D] KOG0580 Serine/threonine protein kinase
Length = 272
Score = 112 bits (279), Expect = 2e-24
Identities = 85/281 (30%), Positives = 126/281 (44%), Gaps = 26/281 (9%)
Query: 3 SLQQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSN--EPIDL 60
+L +F++ +G+G FG V+LA + K +A+K I ++ E
Sbjct: 6 TLDRFEIGRLLGRGKFGQVWLAR-----------EREKGFIVALKIIPIKEIQTVETARQ 54
Query: 61 LLKEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXT-EQTTCFI 119
+ +EI S L P I YG F N+Y+++EY E+ T
Sbjct: 55 IRREIEIHSNLKHPNILRMYGHFHDKDNIYLILEYAGKGEFFKFLSDRGGKFGEKETSLY 114
Query: 120 ILQVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTF 179
I QV AL Y+ E +IHRD+K N+LL D ++++AD G + + K TF
Sbjct: 115 IRQVMLALTYMKECNVIHRDIKPENLLLGSDNQLKIADFGW-------AVYNADKRRMTF 167
Query: 180 VGTPFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMR--IPKLNAD 237
GT ++APE++ N +D D+W LGI T E L GK P +S MR K+N+
Sbjct: 168 CGTMEYLAPEMVNNDIHDSGIDLWCLGILTYEFLMGKTP---FESKNRNMREAYKKINSL 224
Query: 238 SILRNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKK 278
IS DFI L P R + L H ++ K
Sbjct: 225 KYTIPETISSNASDFISRLLVLSPGDRMELTEALNHPFIVK 265
>7297611 [T] KOG0614 cGMP-dependent protein kinase
Length = 1003
Score = 112 bits (279), Expect = 2e-24
Identities = 82/281 (29%), Positives = 127/281 (45%), Gaps = 22/281 (7%)
Query: 2 LSLQQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLL 61
+++ + + + +G G FG V L Y NQ+ KI K + + +K +EH +++
Sbjct: 689 VAISELKKIATLGCGAFGRVDLVAY---NQQALALKIIKKIEV-VKQDQIEHVYNEKNVM 744
Query: 62 LKEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIIL 121
+K P+I Y T+ D +Y +ME C E+T FI
Sbjct: 745 IK------CRQSPFIVQLYRTYRNDKYVYFLMEACMGGDVWTVMSKRQYFDEKTAKFIAG 798
Query: 122 QVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVG 181
V A +YLH I+RDLK N++L DG +L D G ++ N + NTF G
Sbjct: 799 CVVEAFDYLHSHHFIYRDLKPENLMLGTDGYCKLVDFGFAKFVRQN------EKTNTFAG 852
Query: 182 TPFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILR 241
TP ++APEII ++ +D D W+LGI ELL GK P ++ +K +I D I
Sbjct: 853 TPEYVAPEIILDRGHDRAVDYWALGILVYELLVGKTPFRGVNQIKIYQQILS-GIDVIHM 911
Query: 242 NMDISPLGKDFIRSCLQQDP-----NQRPTCKQLLQHKWLK 277
I + +R +Q P QR + +H W +
Sbjct: 912 PSRIPKSAQHLVRHLCKQLPAERLGYQRKGIADIKRHSWFE 952
>7290249 [R] KOG0586 Serine/threonine protein kinase
Length = 1398
Score = 112 bits (279), Expect = 2e-24
Identities = 89/310 (28%), Positives = 144/310 (45%), Gaps = 42/310 (13%)
Query: 7 FQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEP-IDLLLKEI 65
+ + +GKGNF V LA + +I KN +AIK I+ ++ + + +E+
Sbjct: 141 YDIERTIGKGNFAVVKLARH----------RITKN-EVAIKIIDKSQLDQTNLQKVYREV 189
Query: 66 YFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVCH 125
+ L P+I Y +YIV EY S +E F Q+
Sbjct: 190 EIMKRLKHPHIIKLYQVMETKNMIYIVSEYASQGEIFDYIAKYGRMSESAARFKFWQIIS 249
Query: 126 ALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFW 185
A+EY H+K ++HRDLKA N+LL+ + +++AD G + K G+ L T+ G+P +
Sbjct: 250 AVEYCHKKGIVHRDLKAENLLLDLNMNIKIADFGFSNHFK------PGELLATWCGSPPY 303
Query: 186 MAPEIIKNQSYDG-KCDIWSLGITTLELLNGKPPM--SHLDSMK-----ALMRIPKLNAD 237
APE+ + + Y G + DIWSLG+ L+ G P S L S++ RIP
Sbjct: 304 AAPEVFEGKQYTGPEIDIWSLGVVLYVLVCGALPFDGSTLQSLRDRVLSGRFRIP----- 358
Query: 238 SILRNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKKCSITNIMEEITVMKTNQIL 297
+S + IR L +P +R T Q+ +H+W+ ++E + + K N L
Sbjct: 359 -----FFMSSECEHLIRRMLVLEPTRRYTIDQIKRHRWM----CPELLEHVLIAKYN--L 407
Query: 298 SKEKPRSCKP 307
E+ S +P
Sbjct: 408 GAERQTSVEP 417
>YKL166c [T] KOG0616 cAMP-dependent protein kinase catalytic subunit (PKA)
Length = 398
Score = 111 bits (278), Expect = 2e-24
Identities = 75/262 (28%), Positives = 124/262 (46%), Gaps = 20/262 (7%)
Query: 3 SLQQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLL 62
SL FQ+L +G G+FG V+L + + + K+ + +K +EH+N+
Sbjct: 84 SLSDFQILRTLGTGSFGRVHLIRSNHNGRFYALKTLKKHTIVKLK--QVEHTND------ 135
Query: 63 KEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQ 122
E LS + P+I +GTF +++VM+Y F +
Sbjct: 136 -ERRMLSIVSHPFIIRMWGTFQDSQQVFMVMDYIEGGELFSLLRKSQRFPNPVAKFYAAE 194
Query: 123 VCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGT 182
VC ALEYLH K +I+RDLK NILL+ +G +++ D G ++ T GT
Sbjct: 195 VCLALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGF--------AKYVPDVTYTLCGT 246
Query: 183 PFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRN 242
P ++APE++ + Y+ D WS G+ E+L G P + ++MK I LNA+
Sbjct: 247 PDYIAPEVVSTKPYNKSVDWWSFGVLIYEMLAGYTPFYNSNTMKTYENI--LNAELKFPP 304
Query: 243 MDISPLGKDFIRSCLQQDPNQR 264
P +D ++ + +D ++R
Sbjct: 305 F-FHPDAQDLLKKLITRDLSER 325
>At3g04810 [R] KOG0589 Serine/threonine protein kinase
Length = 606
Score = 111 bits (278), Expect = 2e-24
Identities = 75/277 (27%), Positives = 129/277 (46%), Gaps = 21/277 (7%)
Query: 4 LQQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLK 63
++ +++LE +GKG+FG L + + + K + LA + S +
Sbjct: 1 MENYEVLEQIGKGSFGSALLVRH----KHEKKLYVLKKIRLARQTGRTRRSAH------Q 50
Query: 64 EIYFLSTLHCPYITHYYGTFTGD-CNLYIVMEYCSXXXXXXXXXXXXXX--TEQTTCFII 120
E+ +S +H P+I Y ++ C + I++ YC TE+ C +
Sbjct: 51 EMELISKIHNPFIVEYKDSWVEKGCYVCIIIGYCKGGDMAEAIKKTNGVHFTEEKLCKWL 110
Query: 121 LQVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFV 180
+Q+ ALEYLH ++HRD+K +NI L D ++RL D G+ L + ++ V
Sbjct: 111 VQILLALEYLHANHILHRDVKCSNIFLTKDQDIRLGDFGLAKVLTSDDL------ASSVV 164
Query: 181 GTPFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSIL 240
GTP +M PE++ + Y K DIWSLG E+ KP D + RI + +
Sbjct: 165 GTPSYMCPELLADIPYGSKSDIWSLGCCMYEMTAMKPAFKAFDMQGLINRINRSIVPPL- 223
Query: 241 RNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLK 277
S + ++S L+++P RP+ +LL+ L+
Sbjct: 224 -PAQYSAAFRGLVKSMLRKNPELRPSAAELLRQPLLQ 259
>SPCC18B5.11c [D] KOG0615 Serine/threonine protein kinase Chk2 and related
proteins
Length = 460
Score = 111 bits (277), Expect = 3e-24
Identities = 80/278 (28%), Positives = 129/278 (45%), Gaps = 21/278 (7%)
Query: 7 FQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEIY 66
++++ +G G F V LA + S + I K K + ++ +EI
Sbjct: 167 YEIIRTLGSGTFAVVKLAVEVNSGKWYAIKIINKR-----KILLTSSEKRATEMFQREID 221
Query: 67 FLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVCHA 126
L +LH P + + F D L+IVMEY EQ ++ Q+
Sbjct: 222 ILKSLHHPGVVQCHEIFENDDELFIVMEYVEGGDLMDFLIANGSIDEQDCKPLLKQLLET 281
Query: 127 LEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHG-GKNLNTFVGTPFW 185
L +LH++ + HRD+K NIL+ +D ++++D G+ + HG G L TF GT +
Sbjct: 282 LLHLHKQGVTHRDIKPENILITNDFHLKISDFGLAKVI------HGTGTFLETFCGTMGY 335
Query: 186 MAPEIIKNQS------YDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPK--LNAD 237
+APE++K+++ YD K DIWSLG +L P + K + I K +
Sbjct: 336 LAPEVLKSKNVNLDGGYDDKVDIWSLGCVLYVMLTASIPFASSSQAKCIELISKGAYPIE 395
Query: 238 SILRNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKW 275
+L N +IS G D I L+ +P +R + + LQH W
Sbjct: 396 PLLEN-EISEEGIDLINRMLEINPEKRISESEALQHPW 432
>SPAC17G8.14c [T] KOG0694 Serine/threonine protein kinase
Length = 896
Score = 110 bits (276), Expect = 4e-24
Identities = 83/273 (30%), Positives = 123/273 (44%), Gaps = 35/273 (12%)
Query: 2 LSLQQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEH--SNEPID 59
++L F L +GKGNFG V LA Y K+ K AIK + E NE ++
Sbjct: 567 VTLDDFTFLAVLGKGNFGKVMLAEY----------KVNKKF-YAIKVLKKEAILKNEELE 615
Query: 60 LLLKEIYFLSTLHC---PYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTT 116
L E + + P++ + + +F +Y VMEY ++
Sbjct: 616 SLKTEKHVFEVANKEKHPFLLNLFASFQTSTRVYFVMEYILGGDLMVHIQRQQFSVKRAR 675
Query: 117 CFIILQVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNL 176
F +VC AL+Y HE + +RDLK NILL DG +R+AD G+ + G
Sbjct: 676 -FYGAEVCLALKYFHENGIAYRDLKLDNILLCPDGHIRIADYGLCKENMLL-----GNTT 729
Query: 177 NTFVGTPFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNA 236
+TF GTP +MAPEI+ Q Y D W+ G+ ++L G+ P D +
Sbjct: 730 STFCGTPEFMAPEILLEQQYSKDVDWWAFGVLMYQMLLGQSPFKGEDEEEIF-------- 781
Query: 237 DSILRNMDISPLGK-----DFIRSCLQQDPNQR 264
D+IL + + P+ +R L +DPNQR
Sbjct: 782 DAILSDEPLFPINMPADAVSLLRGLLTRDPNQR 814
>Hs5579478 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 393
Score = 110 bits (276), Expect = 4e-24
Identities = 80/318 (25%), Positives = 141/318 (44%), Gaps = 68/318 (21%)
Query: 7 FQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEIY 66
F+ + +G GN G V+ + P + +A K I+LE + +++E+
Sbjct: 68 FEKISELGAGNGGVVFKVSHK-----------PSGLVMARKLIHLEIKPAIRNQIIRELQ 116
Query: 67 FLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVCHA 126
L + PYI +YG F D + I ME+ EQ + + V
Sbjct: 117 VLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKG 176
Query: 127 LEYLHEK-RLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFW 185
L YL EK +++HRD+K +NIL+N GE++L D GV+GQL + N+FVGT +
Sbjct: 177 LTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA-------NSFVGTRSY 229
Query: 186 MAPEIIKNQSYDGKCDIWSLGITTLEL--------------------------------- 212
M+PE ++ Y + DIWS+G++ +E+
Sbjct: 230 MSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPR 289
Query: 213 ------------LNGKPPMSHLDSMKALMRIPKLNADSILRNMDISPLGKDFIRSCLQQD 260
++ +PPM+ + + ++ P S + +++ +DF+ CL ++
Sbjct: 290 PRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEF----QDFVNKCLIKN 345
Query: 261 PNQRPTCKQLLQHKWLKK 278
P +R KQL+ H ++K+
Sbjct: 346 PAERADLKQLMVHAFIKR 363
>Hs4505695 [T] KOG0592 3-phosphoinositide-dependent protein kinase (PDK1)
Length = 556
Score = 110 bits (276), Expect = 4e-24
Identities = 76/268 (28%), Positives = 120/268 (44%), Gaps = 19/268 (7%)
Query: 5 QQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEH--SNEPIDLLL 62
+ F+ + +G+G+F V LA L +++E AIK + H + +
Sbjct: 80 EDFKFGKILGEGSFSTVVLARELATSRE-----------YAIKILEKRHIIKENKVPYVT 128
Query: 63 KEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQ 122
+E +S L P+ Y TF D LY + Y E T F +
Sbjct: 129 RERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAE 188
Query: 123 VCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGT 182
+ ALEYLH K +IHRDLK NILLN+D +++ D G L S + N+FVGT
Sbjct: 189 IVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQ---ARANSFVGT 245
Query: 183 PFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRN 242
+++PE++ +S D+W+LG +L+ G PP + +I KL D +
Sbjct: 246 AQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEK- 304
Query: 243 MDISPLGKDFIRSCLQQDPNQRPTCKQL 270
P +D + L D +R C+++
Sbjct: 305 --FFPKARDLVEKLLVLDATKRLGCEEM 330
>CE24761 [D] KOG0580 Serine/threonine protein kinase
Length = 305
Score = 110 bits (276), Expect = 4e-24
Identities = 75/278 (26%), Positives = 121/278 (42%), Gaps = 25/278 (8%)
Query: 3 SLQQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLL 62
++ F++ +GKG FG VYLA + + K+ ++ +EH E
Sbjct: 26 TINDFEIGRPLGKGKFGSVYLARTKTGHFHVAIKVLFKSQLISG---GVEHQLE------ 76
Query: 63 KEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQ 122
+EI S L+ P I Y F +Y+V+EY +E T + +
Sbjct: 77 REIEIQSHLNHPNIIKLYTYFWDAKKIYLVLEYAPGGEMYKQLTVSKRFSEPTAAKYMYE 136
Query: 123 VCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGT 182
+ AL Y H K +IHRD+K N+L+ GE+++ D G + N + T GT
Sbjct: 137 IADALSYCHRKNVIHRDIKPENLLIGSQGELKIGDFGWSVHAPSNKRQ-------TMCGT 189
Query: 183 PFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLN---ADSI 239
++ PE++ + D+W++G+ E L GKPP H D K I DS+
Sbjct: 190 MDYLPPEMVNGADHSDAVDLWAIGVLCYEFLVGKPPFEHEDQSKTYAAIKAARFTYPDSV 249
Query: 240 LRNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLK 277
+ +D I L DP R T +Q+ +H W++
Sbjct: 250 KKG------ARDLIGRLLVVDPKARCTLEQVKEHYWIQ 281
>At3g08720 [RT] KOG0598 Ribosomal protein S6 kinase and related proteins
Length = 471
Score = 110 bits (276), Expect = 4e-24
Identities = 76/282 (26%), Positives = 132/282 (45%), Gaps = 24/282 (8%)
Query: 1 MLSLQQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDL 60
++ ++ F++L+ VG+G FG VY ++ T V K + H+ +
Sbjct: 134 VVGIEDFEVLKVVGQGAFGKVYQVR-----KKDTSEIYAMKVMRKDKIVEKNHA----EY 184
Query: 61 LLKEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFII 120
+ E L+ + P+I +F LY+V+++ + E
Sbjct: 185 MKAERDILTKIDHPFIVQLKYSFQTKYRLYLVLDFINGGHLFFQLYHQGLFREDLARVYT 244
Query: 121 LQVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFV 180
++ A+ +LHEK ++HRDLK NIL++ DG V L D G+ + + N+ N+
Sbjct: 245 AEIVSAVSHLHEKGIMHRDLKPENILMDVDGHVMLTDFGLAKEFEENTRS------NSMC 298
Query: 181 GTPFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSIL 240
GT +MAPEI++ + +D D WS+GI E+L GKPP L S + + K+ D I
Sbjct: 299 GTTEYMAPEIVRGKGHDKAADWWSVGILLYEMLTGKPPF--LGSKGKIQQ--KIVKDKIK 354
Query: 241 RNMDISPLGKDFIRSCLQQDPNQR-----PTCKQLLQHKWLK 277
+S ++ LQ++P +R +++ +HKW K
Sbjct: 355 LPQFLSNEAHALLKGLLQKEPERRLGSGPSGAEEIKKHKWFK 396
>At1g07150 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 499
Score = 110 bits (276), Expect = 4e-24
Identities = 86/276 (31%), Positives = 131/276 (47%), Gaps = 29/276 (10%)
Query: 12 CVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHS-NEPIDLLLKEI-YFLS 69
C+G+G FG V A T+ ++ A+K ++L S + L EI F S
Sbjct: 28 CIGRGCFGAVSTAI------SKTNGEV-----FAVKSVDLATSLPTQSESLENEISVFRS 76
Query: 70 TLHCPYITHYYGT------FTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQV 123
PYI + G T NLY+ EY E +
Sbjct: 77 LKPHPYIVKFLGDGVSKEGTTTFRNLYL--EYLPNGDVASHRAGGKIEDETLLQRYTACL 134
Query: 124 CHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTP 183
AL ++H + +H D+KA NIL++ V+LAD G ++ H + L T G+P
Sbjct: 135 VSALRHVHSQGFVHCDVKARNILVSQSSMVKLADFGSAFRI------HTPRALITPRGSP 188
Query: 184 FWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRNM 243
WMAPE+I+ + + D+WSLG T +E+ GKP + +L RI + + +
Sbjct: 189 LWMAPEVIRREYQGPESDVWSLGCTIIEMFTGKPAWED-HGIDSLSRISFSDELPVFPSK 247
Query: 244 DISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKKC 279
+S +G+DF+ CL++DPNQR +C QLLQH +L +C
Sbjct: 248 -LSEIGRDFLEKCLKRDPNQRWSCDQLLQHPFLSQC 282
>Hs14728804 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 576
Score = 110 bits (275), Expect = 5e-24
Identities = 78/281 (27%), Positives = 127/281 (44%), Gaps = 26/281 (9%)
Query: 13 VGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEIYFLSTLH 72
+G GNF V + + Q A+K I+ D++ EI + +L
Sbjct: 290 IGDGNFAVVKECRHRETRQA-----------YAMKIIDKSRLKGKEDMVDSEILIIQSLS 338
Query: 73 CPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVCHALEYLHE 132
P I + + D +Y+++EY E +I+ +C AL ++H+
Sbjct: 339 HPNIVKLHEVYETDMEIYLILEYVQGGDLFDAIIESVKFPEPDAALMIMDLCKALVHMHD 398
Query: 133 KRLIHRDLKAANILL--NDDGE--VRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFWMAP 188
K ++HRDLK N+L+ N+D ++LAD G+ +H + + T GTP ++AP
Sbjct: 399 KSIVHRDLKPENLLVQRNEDKSTTLKLADFGL--------AKHVVRPIFTVCGTPTYVAP 450
Query: 189 EIIKNQSYDGKCDIWSLGITTLELLNGKPPM-SHLDSMKALMRIPKLNADSILRNM--DI 245
EI+ + Y + D+W+ G+ LL G PP S L I +L L +I
Sbjct: 451 EILSEKGYGLEVDMWAAGVILYILLCGFPPFRSPERDQDELFNIIQLGHFEFLPPYWDNI 510
Query: 246 SPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKKCSITNIME 286
S KD + L DP +R T Q+LQH W++ TN ++
Sbjct: 511 SDAAKDLVSRLLVVDPKKRYTAHQVLQHPWIETAGKTNTVK 551
>7299322 [R] KOG0611 Predicted serine/threonine protein kinase
Length = 434
Score = 110 bits (275), Expect = 5e-24
Identities = 77/279 (27%), Positives = 132/279 (46%), Gaps = 24/279 (8%)
Query: 3 SLQQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDL-- 60
S+ +F +++ +G+G +G V L + QE +AIK I DL
Sbjct: 78 SILKFDIIKKLGQGTYGKVQLGINKETGQE-----------VAIKTIKKCKIEAEADLVR 126
Query: 61 LLKEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFII 120
+ +E+ +S++H P I H Y F + +VME+ + TE+ I
Sbjct: 127 IRREVQIMSSVHHPNIIHIYEVFENREKMVLVMEFAAGGELYDYLSERKVLTEEEARRIF 186
Query: 121 LQVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFV 180
QV A+ Y H+ ++ HRDLK NILL++ G ++AD G++ F+ R L TF
Sbjct: 187 RQVATAVYYCHKHKICHRDLKLENILLDEKGNAKIADFGLSN--VFDDQR----LLGTFC 240
Query: 181 GTPFWMAPEIIKNQSYDG-KCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSI 239
G+P + +PEI++ Y G + D WSLG+ L+ G P + + + +I + +
Sbjct: 241 GSPLYASPEIVEGTPYQGPEVDCWSLGVLLYTLVYGSMPFDGSNFKRLVKQISQGDYYEP 300
Query: 240 LRNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKK 278
+ S L +D + C P +R + +Q+ H W+ +
Sbjct: 301 RKPSRASTLIRDMLTVC----PRKRASIEQICSHWWVNE 335
>At5g56580 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 356
Score = 110 bits (274), Expect = 6e-24
Identities = 80/289 (27%), Positives = 135/289 (46%), Gaps = 32/289 (11%)
Query: 2 LSLQQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLL 61
++ + + ++ +GKG+ G V L + + A+K I + E +
Sbjct: 65 ITAEDLETVKVIGKGSGGVVQLVRHKWVGKF-----------FAMKVIQMNIQEEIRKQI 113
Query: 62 LKEIYF-LSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFII 120
++E+ ++ CP++ Y +F + +V+EY E +
Sbjct: 114 VQELKINQASSQCPHVVVCYHSFYHNGAFSLVLEYMDRGSLADVIRQVKTILEPYLAVVC 173
Query: 121 LQVCHALEYLH-EKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTF 179
QV L YLH E+ +IHRD+K +N+L+N GEV+++D GV+ L + + +TF
Sbjct: 174 KQVLLGLVYLHNERHVIHRDIKPSNLLVNHKGEVKISDFGVSASLASSMGQR-----DTF 228
Query: 180 VGTPFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGK----------PPMSHLDSMKALM 229
VGT +M+PE I +YD DIWSLG++ LE G+ P S + + A++
Sbjct: 229 VGTYNYMSPERISGSTYDYSSDIWSLGMSVLECAIGRFPYLESEDQQNPPSFYELLAAIV 288
Query: 230 RIPKLNADSILRNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKK 278
P A S SP F+ +C+Q+DP R + LL H ++KK
Sbjct: 289 ENPPPTAPS----DQFSPEFCSFVSACIQKDPPARASSLDLLSHPFIKK 333
>7301734 [T] KOG0694 Serine/threonine protein kinase
Length = 739
Score = 110 bits (274), Expect = 6e-24
Identities = 78/267 (29%), Positives = 125/267 (46%), Gaps = 20/267 (7%)
Query: 3 SLQQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLL 62
SL F ++ +GKG+FG V LA G+++ + K+ + ++ +D +
Sbjct: 404 SLLDFNFIKVLGKGSFGKVMLAEKKGTDEIYAIKVLKKDAII---------QDDDVDCTM 454
Query: 63 --KEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFII 120
K I L+ H P++T + F L+ VMEY + F
Sbjct: 455 TEKRILALAANH-PFLTALHSCFQTPDRLFFVMEYVNGGDLMFQIQKARRFEASRAAFYA 513
Query: 121 LQVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFV 180
+V AL++LH +I+RDLK NILL+ +G +LAD G+ + N G TF
Sbjct: 514 AEVTLALQFLHTHGVIYRDLKLDNILLDQEGHCKLADFGMCKEGIMN-----GMLTTTFC 568
Query: 181 GTPFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSIL 240
GTP ++APEI+K Q Y D W+LG+ E++ G+PP D+ L + D +L
Sbjct: 569 GTPDYIAPEILKEQEYGASVDWWALGVLMYEMMAGQPPF-EADNEDEL--FDSIMHDDVL 625
Query: 241 RNMDISPLGKDFIRSCLQQDPNQRPTC 267
+ +S ++ L ++P QR C
Sbjct: 626 YPVWLSREAVSILKGFLTKNPEQRLGC 652
>At4g12020_6 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 422
Score = 110 bits (274), Expect = 6e-24
Identities = 75/217 (34%), Positives = 108/217 (49%), Gaps = 20/217 (9%)
Query: 65 IYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVC 124
I LS L I Y GT + NLYI +E + + + Q+
Sbjct: 203 IALLSQLQHQNIVRYRGTTKDESNLYIFLELVTQGSLRKLYQRNQLGDSVVSLYT-RQIL 261
Query: 125 HALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPF 184
L+YLH+K IHR++K AN+L++ +G V+LAD G+ + T +
Sbjct: 262 DGLKYLHDKGFIHRNIKCANVLVDANGTVKLADFGLAKVMSLWRTPYWN----------- 310
Query: 185 WMAPEIIKN-QSYDG---KCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSIL 240
WMAPE+I N + YDG DIWSLG T LE+L G+ P S L+ AL I +
Sbjct: 311 WMAPEVILNPKDYDGYGTPADIWSLGCTVLEMLTGQIPYSDLEIGTALYNI---GTGKLP 367
Query: 241 RNMDISPL-GKDFIRSCLQQDPNQRPTCKQLLQHKWL 276
+ DI L +DFI +CL+ +P +RPT +LL H ++
Sbjct: 368 KIPDILSLDARDFILTCLKVNPEERPTAAELLNHPFV 404
>YPL209c [D] KOG0580 Serine/threonine protein kinase
Length = 367
Score = 109 bits (273), Expect = 8e-24
Identities = 76/275 (27%), Positives = 123/275 (44%), Gaps = 18/275 (6%)
Query: 2 LSLQQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLL 61
LSL F+L + +GKG FG VY + + + K I NL+
Sbjct: 99 LSLDDFELGKKLGKGKFGKVYCVRHRSTGYICALKVMEKE---EIIKYNLQKQ------F 149
Query: 62 LKEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIIL 121
+E+ ++L+ P +T YG F + +Y++MEY + I
Sbjct: 150 RREVEIQTSLNHPNLTKSYGYFHDEKRVYLLMEYLVNGEMYKLLRLHGPFNDILASDYIY 209
Query: 122 QVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVG 181
Q+ +AL+Y+H+K +IHRD+K NIL+ + ++L D G ++ T G
Sbjct: 210 QIANALDYMHKKNIIHRDIKPENILIGFNNVIKLTDFG------WSIINPPENRRKTVCG 263
Query: 182 TPFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILR 241
T +++PE+++++ YD D W+LG+ ELL G PP RI L+ I
Sbjct: 264 TIDYLSPEMVESREYDHTIDAWALGVLAFELLTGAPPFEEEMKDTTYKRIAALD---IKM 320
Query: 242 NMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWL 276
+IS +D I L+ DP R + H W+
Sbjct: 321 PSNISQDAQDLILKLLKYDPKDRMRLGDVKMHPWI 355
>Hs7662170 [R] KOG0611 Predicted serine/threonine protein kinase
Length = 661
Score = 109 bits (273), Expect = 8e-24
Identities = 75/274 (27%), Positives = 128/274 (46%), Gaps = 24/274 (8%)
Query: 6 QFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDL--LLK 63
+++L E +GKG +G V A S + +AIK I + + D+ + +
Sbjct: 54 RYELQETLGKGTYGKVKRATERFSGRV-----------VAIKSIRKDKIKDEQDMVHIRR 102
Query: 64 EIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQV 123
EI +S+L+ P+I Y F + I+MEY S +E+ T Q+
Sbjct: 103 EIEIMSSLNHPHIISIYEVFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQI 162
Query: 124 CHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTP 183
A+ Y H+ ++HRDLK NILL+D+ +++AD G++ + + K L TF G+P
Sbjct: 163 VSAVHYCHKNGVVHRDLKLENILLDDNCNIKIADFGLSNLYQKD------KFLQTFCGSP 216
Query: 184 FWMAPEIIKNQSYDG-KCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRN 242
+ +PEI+ + Y G + D W+LG+ L+ G P D + +I +
Sbjct: 217 LYASPEIVNGRPYRGPEVDSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGEYREPTQP 276
Query: 243 MDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWL 276
D + IR L +P++R T + + H W+
Sbjct: 277 SD----ARGLIRWMLMVNPDRRATIEDIANHWWV 306
>CE24941 [T] KOG0983 Mitogen-activated protein kinase (MAPK) kinase
MKK7/JNKK2
Length = 435
Score = 109 bits (273), Expect = 8e-24
Identities = 79/243 (32%), Positives = 119/243 (48%), Gaps = 19/243 (7%)
Query: 44 LAIKCINLEHSNEPIDLLLKEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEY----CSXX 99
+A+K + + E + +L+++ +S + P+I YG F D ++ I M+ C
Sbjct: 146 MAVKTMYKNDNKENLKRILRDVRIMSMCNSPFIVTSYGYFMFDSSVKICMQIMSACCEKL 205
Query: 100 XXXXXXXXXXXXTEQTTCFIILQVCHALEYLHEKR-LIHRDLKAANILLNDDGEVRLADL 158
E I+ AL+YL EK +IHRD+K +NIL +D G V+L D
Sbjct: 206 LRRIYHSKLDFFPEFVAGHIVYSAISALDYLKEKHSIIHRDIKPSNILFDDSGNVKLCDF 265
Query: 159 GVTGQLKFNSTRHGGKNLNTFVGTPFWMAPE---IIKNQSYDGKCDIWSLGITTLELLNG 215
G++G + +S H + G P +MAPE I N YD + D+WSLGIT +L+ G
Sbjct: 266 GISGFMT-DSMAH-----SKSAGCPPYMAPERLTIETNSKYDVRSDVWSLGITVYQLVTG 319
Query: 216 KPPMSHLD-SMKALMRIPKLNADS-ILR---NMDISPLGKDFIRSCLQQDPNQRPTCKQL 270
P D L I LN S LR SPL +F+ CL++D +RP +QL
Sbjct: 320 LYPFPLNDMEFTTLTIIANLNLPSPSLREETKRSFSPLFIEFLDLCLRKDVRERPEYRQL 379
Query: 271 LQH 273
++H
Sbjct: 380 MKH 382
>At2g25880 [D] KOG0580 Serine/threonine protein kinase
Length = 282
Score = 109 bits (273), Expect = 8e-24
Identities = 77/272 (28%), Positives = 126/272 (46%), Gaps = 22/272 (8%)
Query: 7 FQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNV--PLAIKCINLEHSNEPIDLLLKE 64
F + + +G+G FG VYLA ++ +D + V ++ +EH L +E
Sbjct: 19 FDIGKPLGRGKFGHVYLAR-----EKRSDHIVALKVLFKAQLQQSQVEHQ------LRRE 67
Query: 65 IYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVC 124
+ S L P I YG F +Y+++EY +E+ + +
Sbjct: 68 VEIQSHLRHPNILRLYGYFYDQKRVYLILEYAVRGELYKELQKCKYFSERRAATYVASLA 127
Query: 125 HALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPF 184
AL Y H K +IHRD+K N+L+ GE+++AD G + FN R T GT
Sbjct: 128 RALIYCHGKHVIHRDIKPENLLIGAQGELKIADFGWSVHT-FNRRR-------TMCGTLD 179
Query: 185 WMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRNMD 244
++ PE++++ +D DIWSLGI E L G PP + + RI +++ + +
Sbjct: 180 YLPPEMVESVEHDASVDIWSLGILCYEFLYGVPPFEAREHSETYKRIVQVDLKFPPKPI- 238
Query: 245 ISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWL 276
+S KD I L ++ QR +LL+H W+
Sbjct: 239 VSSSAKDLISQMLVKESTQRLALHKLLEHPWI 270
>At1g54510 [R] KOG0589 Serine/threonine protein kinase
Length = 612
Score = 109 bits (273), Expect = 8e-24
Identities = 85/319 (26%), Positives = 147/319 (45%), Gaps = 35/319 (10%)
Query: 4 LQQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLK 63
++Q++ LE +GKG+FG L + ++ + K + LA + S +
Sbjct: 1 MEQYEFLEQIGKGSFGSALLVRHKHEKKK----YVLKKIRLARQTQRTRRSAH------Q 50
Query: 64 EIYFLSTLHCPYITHYYGTFTGD-CNLYIVMEYCSXXXXXXXXXXXXXX--TEQTTCFII 120
E+ +S + P+I Y ++ C + IV+ YC E+ C +
Sbjct: 51 EMELISKMRHPFIVEYKDSWVEKACYVCIVIGYCEGGDMAQAIKKSNGVHFQEEKLCKWL 110
Query: 121 LQVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFV 180
+Q+ LEYLH ++HRD+K +NI L + ++RL D G+ L + ++ V
Sbjct: 111 VQLLMGLEYLHSNHILHRDVKCSNIFLTKEQDIRLGDFGLAKILTSDDL------TSSVV 164
Query: 181 GTPFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSIL 240
GTP +M PE++ + Y K DIWSLG E+ KP D M+AL I K+N +I+
Sbjct: 165 GTPSYMCPELLADIPYGSKSDIWSLGCCIYEMAYLKPAFKAFD-MQAL--INKIN-KTIV 220
Query: 241 RNMDISPLG--KDFIRSCLQQDPNQRPTCKQLLQHKWLKKCSITNIMEEITVMKTNQILS 298
+ G + ++S L+++P RP+ LL+H L+ V+ L+
Sbjct: 221 SPLPAKYSGPFRGLVKSMLRKNPEVRPSASDLLRHPHLQP----------YVLDVKLRLN 270
Query: 299 KEKPRSCKPRFPLSDKVYK 317
+ ++ P P S ++ K
Sbjct: 271 NLRRKTLPPELPSSKRIMK 289
>Hs21729895 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 448
Score = 109 bits (272), Expect = 1e-23
Identities = 78/278 (28%), Positives = 130/278 (46%), Gaps = 28/278 (10%)
Query: 5 QQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKE 64
Q + + +G GN G VY A++ +P LA+K I L+ + E ++ E
Sbjct: 164 QDIRYRDTLGHGNGGTVYKAYH-----------VPSGKILAVKVILLDITLELQKQIMSE 212
Query: 65 IYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVC 124
+ L YI +YG F + + I C+ E I + V
Sbjct: 213 LEILYKCDSSYIIGFYGAFFVENRISI----CTEFMDGGSLDVYRKMPEHVLGRIAVAVV 268
Query: 125 HALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPF 184
L YL +++HRD+K +N+L+N G+V+L D GV+ QL NS T+VGT
Sbjct: 269 KGLTYLWSLKILHRDVKPSNMLVNTRGQVKLCDFGVSTQL-VNSI------AKTYVGTNA 321
Query: 185 WMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRNMD 244
+MAPE I + Y D+WSLGI+ +EL G+ P + + + +L + +
Sbjct: 322 YMAPERISGEQYGIHSDVWSLGISFMELALGRFPYPQIQKNQGSLMPLQLLQCIVDEDSP 381
Query: 245 ISPLGK------DFIRSCLQQDPNQRPTCKQLLQHKWL 276
+ P+G+ FI C+++ P +RP ++L+ H ++
Sbjct: 382 VLPVGEFSEPFVHFITQCMRKQPKERPAPEELMGHPFI 419
>At5g28290 [R] KOG0589 Serine/threonine protein kinase
Length = 568
Score = 109 bits (272), Expect = 1e-23
Identities = 80/310 (25%), Positives = 146/310 (46%), Gaps = 26/310 (8%)
Query: 4 LQQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLK 63
++ +++LE +GKG+FG L + + + K + LA + S +
Sbjct: 1 MEHYEVLEQIGKGSFGSALLVRH----KHEKKLYVLKKIRLARQTGRTRRSAH------Q 50
Query: 64 EIYFLSTLHCPYITHYYGTFTGD-CNLYIVMEYCSXXXXXXXXXXXXXX--TEQTTCFII 120
E+ +S + P+I Y ++ C + IV+ YC +E+ C +
Sbjct: 51 EMELISKIRNPFIVEYKDSWVEKGCYVCIVIGYCKGGDMAEAIKKANGVEFSEEKLCKWL 110
Query: 121 LQVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFV 180
+Q+ ALEYLH ++HRD+K +NI L D ++RL D G+ L + ++ V
Sbjct: 111 VQLLMALEYLHASHILHRDVKCSNIFLTKDQDIRLGDFGLAKILTSDDL------ASSVV 164
Query: 181 GTPFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSIL 240
GTP +M PE++ + Y K DIWSLG E+ KP D + RI + SI+
Sbjct: 165 GTPSYMCPELLADIPYGSKSDIWSLGCCMYEMTALKPAFKAFDMQGLINRINR----SIV 220
Query: 241 RNM--DISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKKCSITNIMEEITVMKTNQILS 298
+ S + ++S L+++P RP+ LL+ L+ + ++ +++ + + + S
Sbjct: 221 APLPAQYSTAFRSLVKSMLRKNPELRPSASDLLRQPLLQP-YVQKVLLKLSFREHDTLPS 279
Query: 299 KEKPRSCKPR 308
+ + RS P+
Sbjct: 280 ESERRSSYPQ 289
>Hs4507831 [OUT] KOG0595 Serine/threonine-protein kinase involved in autophagy
Length = 1050
Score = 108 bits (271), Expect = 1e-23
Identities = 83/282 (29%), Positives = 127/282 (44%), Gaps = 29/282 (10%)
Query: 6 QFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEI 65
+F + +G G F V+ G ++E D ++ A+KCIN ++ + LL KEI
Sbjct: 15 EFSRKDLIGHGAFAVVFK----GRHREKHDLEV------AVKCINKKNLAKSQTLLGKEI 64
Query: 66 YFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVCH 125
L L I Y ++Y+VMEYC+ +E T + Q+
Sbjct: 65 KILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAG 124
Query: 126 ALEYLHEKRLIHRDLKAANILLNDDG---------EVRLADLGVTGQLKFNSTRHGGKNL 176
A+ LH K +IHRDLK NILL++ V++AD G L+ N
Sbjct: 125 AMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMM------A 178
Query: 177 NTFVGTPFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPM--SHLDSMKALMRIPKL 234
T G+P +MAPE+I +Q YDGK D+WS+G + L GK P S ++ K
Sbjct: 179 ATLCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKT 238
Query: 235 NADSILRNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWL 276
+I R +PL + + + LQ++ R + H +L
Sbjct: 239 LVPTIPRETS-APL-RQLLLALLQRNHKDRMDFDEFFHHPFL 278
>Hs20535816 [T] KOG0695 Serine/threonine protein kinase
Length = 592
Score = 108 bits (270), Expect = 2e-23
Identities = 74/278 (26%), Positives = 124/278 (43%), Gaps = 31/278 (11%)
Query: 2 LSLQQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLL 61
L LQ F L+ +G+G++ V L L N + K+ K L H +E ID +
Sbjct: 247 LGLQDFDLIRVIGRGSYAKVLLVR-LKKNDQIYAMKVVKK--------ELVHDDEDIDWV 297
Query: 62 LKEIY-FLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFII 120
E + F P++ + F L++V+EY + E+ F
Sbjct: 298 QTEKHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYA 357
Query: 121 LQVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFV 180
++C AL +LHE+ +I+RDLK N+LL+ DG ++L D G+ G +TF
Sbjct: 358 AEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMC-----KEGLGPGDTTSTFC 412
Query: 181 GTPFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSIL 240
GTP ++APEI++ + Y D W+LG+ E++ G+ P + P +N + L
Sbjct: 413 GTPNYIAPEILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDN------PDMNTEDYL 466
Query: 241 RNM----------DISPLGKDFIRSCLQQDPNQRPTCK 268
+ +S ++ L +DP +R C+
Sbjct: 467 FQVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGCR 504
>Hs10864650 [T] KOG0695 Serine/threonine protein kinase
Length = 592
Score = 108 bits (270), Expect = 2e-23
Identities = 74/278 (26%), Positives = 124/278 (43%), Gaps = 31/278 (11%)
Query: 2 LSLQQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLL 61
L LQ F L+ +G+G++ V L L N + K+ K L H +E ID +
Sbjct: 247 LGLQDFDLIRVIGRGSYAKVLLVR-LKKNDQIYAMKVVKK--------ELVHDDEDIDWV 297
Query: 62 LKEIY-FLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFII 120
E + F P++ + F L++V+EY + E+ F
Sbjct: 298 QTEKHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYA 357
Query: 121 LQVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFV 180
++C AL +LHE+ +I+RDLK N+LL+ DG ++L D G+ G +TF
Sbjct: 358 AEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMC-----KEGLGPGDTTSTFC 412
Query: 181 GTPFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSIL 240
GTP ++APEI++ + Y D W+LG+ E++ G+ P + P +N + L
Sbjct: 413 GTPNYIAPEILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDN------PDMNTEDYL 466
Query: 241 RNM----------DISPLGKDFIRSCLQQDPNQRPTCK 268
+ +S ++ L +DP +R C+
Sbjct: 467 FQVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGCR 504
>7296450 [D] KOG0575 Polo-like serine/threonine protein kinase
Length = 769
Score = 108 bits (270), Expect = 2e-23
Identities = 80/282 (28%), Positives = 138/282 (48%), Gaps = 24/282 (8%)
Query: 3 SLQQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCIN--LEHSNEPIDL 60
+++ +++ +GKG F VY A L ++Q+ +AIK I+ L +
Sbjct: 10 TIEDYEVQHLLGKGGFATVYKARCLHTHQD-----------VAIKMIDKKLIQGTGLTNR 58
Query: 61 LLKEIYFLSTLHCPYITHYYGTFTGDCN-LYIVMEYC-SXXXXXXXXXXXXXXTEQTTCF 118
+ +E+ S L P + Y TF D N +Y+V+E + TE
Sbjct: 59 VRQEVEIHSRLKHPSVLQLY-TFFQDANYVYLVLELAHNGELHRYMNHIARPFTETEAAS 117
Query: 119 IILQVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNT 178
I+ QV L YLH ++HRD+ +N+LL+ + V++AD G+ QLK RH T
Sbjct: 118 ILKQVVAGLLYLHSHNIMHRDISLSNLLLSREMHVKIADFGLATQLKRPDERH-----MT 172
Query: 179 FVGTPFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADS 238
GTP +++PE++ S+ D+WS+G LL G+PP D++++ + K+
Sbjct: 173 MCGTPNYISPEVVSRTSHGLPADVWSVGCMLYTLLVGRPPF-ETDAVQSTLN--KVVMSE 229
Query: 239 ILRNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKKCS 280
+ +S +D I L++ P++R T + +L H ++ KCS
Sbjct: 230 YIMPAHLSYEAQDLINKLLKKLPHERITLEAVLCHPFMLKCS 271
>Hs4557511 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 454
Score = 108 bits (269), Expect = 2e-23
Identities = 78/286 (27%), Positives = 123/286 (42%), Gaps = 17/286 (5%)
Query: 7 FQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEIY 66
+++ E +G G F V G+ +E I K + S E I+ +E+
Sbjct: 13 YEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKR---RLSSSRRGVSREEIE---REVN 66
Query: 67 FLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVCHA 126
L + P I + F ++ +++E S TE + Q+
Sbjct: 67 ILREIRHPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQILDG 126
Query: 127 LEYLHEKRLIHRDLKAANILLNDDG----EVRLADLGVTGQLKFNSTRHGGKNLNTFVGT 182
+ YLH KR+ H DLK NI+L D ++L D G+ +++ G GT
Sbjct: 127 VHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIE------AGNEFKNIFGT 180
Query: 183 PFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRN 242
P ++APEI+ + + D+WS+G+ T LL+G P + L I +N D
Sbjct: 181 PEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEY 240
Query: 243 M-DISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKKCSITNIMEE 287
+ S L KDFIR L +DP +R T Q L+H W+K N+ E
Sbjct: 241 FSNTSELAKDFIRRLLVKDPKRRMTIAQSLEHSWIKAIRRRNVRGE 286
>Hs21361133 [R] KOG0586 Serine/threonine protein kinase
Length = 752
Score = 108 bits (269), Expect = 2e-23
Identities = 82/300 (27%), Positives = 140/300 (46%), Gaps = 55/300 (18%)
Query: 7 FQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSN-EPIDLLLKEI 65
++LL+ +GKGNF V LA ++ + +E +AIK I+ N + L +E+
Sbjct: 56 YRLLKTIGKGNFAKVKLARHILTGRE-----------VAIKIIDKTQLNPTSLQKLFREV 104
Query: 66 YFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVCH 125
+ L+ P I + + LY++MEY S E+ Q C
Sbjct: 105 RIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGKMKEKEARSKFRQGCQ 164
Query: 126 -----------------------ALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTG 162
A++Y H+KR++HRDLKA N+LL+ D +++AD G +
Sbjct: 165 AGQTIKVQVSFDLLSLMFTFIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFS- 223
Query: 163 QLKFNSTRHGGKNLNTFVGTPFWMAPEIIKNQSYDG-KCDIWSLGITTLELLNGKPPMSH 221
N GGK L+TF G+P + APE+ + + YDG + D+WSLG+ L++G P
Sbjct: 224 ----NEFTVGGK-LDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDG 278
Query: 222 LDSMKALMRIPKLNADSILRNMDISPL-----GKDFIRSCLQQDPNQRPTCKQLLQHKWL 276
++K L + +LR P ++ ++ L +P +R T +Q+++ +W+
Sbjct: 279 -QNLKEL-------RERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWI 330
>Hs14196445 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 476
Score = 108 bits (269), Expect = 2e-23
Identities = 79/275 (28%), Positives = 129/275 (46%), Gaps = 25/275 (9%)
Query: 7 FQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEIY 66
F +E +G G F +V+L ++ K+ A+KCI + L EI
Sbjct: 23 FIFMEVLGSGAFSEVFLV------KQRLTGKL-----FALKCIKKSPAFRDSSLE-NEIA 70
Query: 67 FLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVCHA 126
L + I + + Y+VM+ S TE+ +I QV A
Sbjct: 71 VLKKIKHENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSA 130
Query: 127 LEYLHEKRLIHRDLKAANILL---NDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTP 183
++YLHE ++HRDLK N+L ++ ++ + D G++ +++ N ++T GTP
Sbjct: 131 VKYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLS-KMEQNGI------MSTACGTP 183
Query: 184 FWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPK--LNADSILR 241
++APE++ + Y D WS+G+ T LL G PP K +I + +S
Sbjct: 184 GYVAPEVLAQKPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFW 243
Query: 242 NMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWL 276
+ DIS KDFI L++DPN+R TC++ L H W+
Sbjct: 244 D-DISESAKDFICHLLEKDPNERYTCEKALSHPWI 277
>Hs13489054 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 400
Score = 108 bits (269), Expect = 2e-23
Identities = 76/292 (26%), Positives = 131/292 (44%), Gaps = 53/292 (18%)
Query: 39 PKNVPLAIKCINLEHSNEPIDLLLKEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSX 98
P + +A K I+LE + +++E+ L + PYI +YG F D + I ME+
Sbjct: 93 PSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDG 152
Query: 99 XXXXXXXXXXXXXTEQTTCFIILQVCHALEYLHEK-RLIHRDLKAANILLNDDGEVRLAD 157
E+ + + V L YL EK +++HRD+K +NIL+N GE++L D
Sbjct: 153 GSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCD 212
Query: 158 LGVTGQLKFNSTRHGGKNLNTFVGTPFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKP 217
GV+GQL + N+FVGT +MAPE ++ Y + DIWS+G++ +EL G+
Sbjct: 213 FGVSGQLIDSMA-------NSFVGTRSYMAPERLQGTHYSVQSDIWSMGLSLVELAVGRY 265
Query: 218 PMSHLDS--MKALMRIPKLNADS------------------------------------- 238
P+ D+ ++A+ P ++ +
Sbjct: 266 PIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPRPPGRPVSGHGMDSRPAMAIFELLDYI 325
Query: 239 ------ILRNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKKCSITNI 284
L N +P ++F+ CL ++P +R K L H ++K+ + +
Sbjct: 326 VNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERADLKMLTNHTFIKRSEVEEV 377
>YOR351c [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 497
Score = 107 bits (268), Expect = 3e-23
Identities = 95/297 (31%), Positives = 133/297 (43%), Gaps = 49/297 (16%)
Query: 13 VGKGNFGDVYLAHYLGSNQEPTDPKI---PKNVPLAIKCINLEHSNEPIDLLLKEIYFLS 69
VG G FG V + H N + D + P+N A+K I L+ + KE L
Sbjct: 168 VGNGTFGHVLITH----NSKERDEDVCYHPENY--AVKIIKLKPNKFD-----KEARILL 216
Query: 70 TLHCPYITHYYGTFTGDCN-LYIVMEYCSXXXXXXXXXXXXXXT---EQTTCFIILQVCH 125
L P I Y TF N LYI + T E + I+ Q+
Sbjct: 217 RLDHPNIIKVYHTFCDRNNHLYIFQDLIPGGDLFSYLAKGDCLTSMSETESLLIVFQILQ 276
Query: 126 ALEYLHEKRLIHRDLKAANILL---NDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGT 182
AL YLH++ ++HRDLK NILL + LAD G+ L N R ++T VGT
Sbjct: 277 ALNYLHDQDIVHRDLKLDNILLCTPEPCTRIVLADFGIAKDLNSNKER-----MHTVVGT 331
Query: 183 PFWMAPEI-----------------IKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSM 225
P + APE+ ++ + YD KCD+WSLG+ T +L G P S
Sbjct: 332 PEYCAPEVGFRANRKAYQSFSRAATLEQRGYDSKCDLWSLGVITHIMLTGISPFYGDGSE 391
Query: 226 KALM---RIPKLNADSILRNMDI-SPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKK 278
++++ +I KLN L+ DI S K F++ LQ D +R KQ L+H W+ K
Sbjct: 392 RSIIQNAKIGKLNFK--LKQWDIVSDNAKSFVKDLLQTDVVKRLNSKQGLKHIWIAK 446
>CE14798 [RT] KOG0598 Ribosomal protein S6 kinase and related proteins
Length = 422
Score = 107 bits (268), Expect = 3e-23
Identities = 77/261 (29%), Positives = 123/261 (46%), Gaps = 22/261 (8%)
Query: 7 FQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEH---SNEPIDLLLK 63
F L +GKG+FG VY + K K + A+K ++ EH NE ++ +
Sbjct: 94 FDYLTTIGKGSFGRVYQVRH----------KETKKI-YAMKILSKEHIRKKNEVKHVMAE 142
Query: 64 EIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQV 123
++ P++ + +F LY V+++ + +E + F ++
Sbjct: 143 RNVLINNFKHPFLVSLHFSFQNKEKLYFVLDHLNGGELFSHLQREKHFSESRSRFYAAEI 202
Query: 124 CHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTP 183
AL YLHEK +I+RDLK N+LL+D G + L D G+ G K +TF GTP
Sbjct: 203 ACALGYLHEKNIIYRDLKPENLLLDDKGYLVLTDFGLC-----KEDMQGSKTTSTFCGTP 257
Query: 184 FWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRNM 243
++APEII + YD D W LG E++ G PP D + +I +N L++
Sbjct: 258 EYLAPEIILKKPYDKTVDWWCLGSVLYEMIFGLPPFYSKDHNEMYDKI--INQPLRLKH- 314
Query: 244 DISPLGKDFIRSCLQQDPNQR 264
+IS + I LQ+D ++R
Sbjct: 315 NISVPCSELITGLLQKDRSKR 335
>Hs22050308_2 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 291
Score = 107 bits (268), Expect = 3e-23
Identities = 75/273 (27%), Positives = 122/273 (44%), Gaps = 26/273 (9%)
Query: 13 VGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINL-----EHSNEPIDLLLKEIYF 67
+G G F Y A +G+ +A+K + E ++ L +EI
Sbjct: 26 IGLGAFSSCYQAQDVGTG-----------TLMAVKQVTYVRNTSSEQEEVVEALREEIRM 74
Query: 68 LSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVCHAL 127
+S L+ P I G N + +E+ + E Q+ L
Sbjct: 75 MSHLNHPNIIRMLGATCEKSNYNLFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGL 134
Query: 128 EYLHEKRLIHRDLKAANILLNDDGE-VRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFWM 186
YLHE ++IHRD+K AN+L++ G+ +R+AD G +L T G+ +GT +M
Sbjct: 135 SYLHENQIIHRDVKGANLLIDSTGQRLRIADFGAAARLASKGT-GAGEFQGQLLGTIAFM 193
Query: 187 APEIIKNQSYDGKCDIWSLGITTLELLNGKPP------MSHLDSMKALMRIPKLNADSIL 240
APE+++ Q Y CD+WS+G +E+ KPP +HL + ++ A SI
Sbjct: 194 APEVLRGQQYGRSCDVWSVGCAIIEMACAKPPWNAEKHSNHLALIFKVIIASATTAPSIP 253
Query: 241 RNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQH 273
+ +SP +D CL+ P RP ++LL+H
Sbjct: 254 SH--LSPGLRDVALRCLELQPQDRPPSRELLKH 284
>Hs20547806 [R] KOG0589 Serine/threonine protein kinase
Length = 489
Score = 107 bits (267), Expect = 4e-23
Identities = 82/297 (27%), Positives = 133/297 (44%), Gaps = 38/297 (12%)
Query: 4 LQQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLK 63
+ + +L +G+G+FG L + SNQ A+K I L S K
Sbjct: 1 MDDYMVLRMIGEGSFGRALLVQHESSNQM-----------FAMKEIRLPKSFSNTQNSRK 49
Query: 64 EIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXT--EQTTCFIIL 121
E L+ + P I + +F + +LYIVMEYC E
Sbjct: 50 EAVLLAKMKHPNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFT 109
Query: 122 QVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVG 181
Q+C + ++H+KR++HRD+K+ NI L +G+V+L D G + +L N T+VG
Sbjct: 110 QMCLGVNHIHKKRVLHRDIKSKNIFLTQNGKVKLGDFG-SARLLSNPMAFAC----TYVG 164
Query: 182 TPFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILR 241
TP+++ PEI +N Y+ K DIWSLG EL K P ++++ +
Sbjct: 165 TPYYVPPEIWENLPYNNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQ-------- 216
Query: 242 NMDISPLGKDF-------IRSCLQQDPNQRPTCKQLLQH----KWLKKCSITNIMEE 287
ISPL + ++ +++P+ RP+ LL + ++KC I+ E
Sbjct: 217 -GCISPLPSHYSYELQFLVKQMFKRNPSHRPSATTLLSRGIVARLVQKCLPPEIIME 272
>ECU01g0630 [D] KOG0575 Polo-like serine/threonine protein kinase
Length = 488
Score = 107 bits (267), Expect = 4e-23
Identities = 77/278 (27%), Positives = 125/278 (44%), Gaps = 24/278 (8%)
Query: 6 QFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEH--SNEPIDLLLK 63
++ L + +G+G + YLA Q A+K + L+ S + + L
Sbjct: 39 KYMLKKLLGRGAYAQCYLAEIESGEQ------------YAMKVVRLKDIKSRKVHEKLES 86
Query: 64 EIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQV 123
EI S L P + Y +F +++V+E C E+ + Q
Sbjct: 87 EIAIHSKLDNPNVVKMYRSFRSSEYVFMVLELCERGALDALLKRNGKLKERHVARFVKQT 146
Query: 124 CHALEYLHEK-RLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGT 182
L YLH ++HRDLK N+ L+ V++ D G++ +K G+ T GT
Sbjct: 147 VEGLIYLHNSVSVVHRDLKLGNLFLDSKFNVKIGDFGLSAVIK------DGEKKVTMCGT 200
Query: 183 PFWMAPEII--KNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSIL 240
P ++APE++ K + + DIWSLG+ LL G PP +++ + ++ KLN
Sbjct: 201 PNYIAPEVLFGKASGHSFEADIWSLGVIIYTLLVGVPPFQK-KNVEDIYKMIKLNNYIFP 259
Query: 241 RNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKK 278
N D+S D I L +P +RPT + +L HK+L K
Sbjct: 260 ENCDLSSEAIDLITQILNTNPLERPTLEHILSHKFLSK 297
>CE23001 [R] KOG0589 Serine/threonine protein kinase
Length = 579
Score = 107 bits (267), Expect = 4e-23
Identities = 81/268 (30%), Positives = 128/268 (47%), Gaps = 16/268 (5%)
Query: 6 QFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEI 65
+++ + VGKG FG L +E + I K + + +L+ S L L E+
Sbjct: 170 RYERIRTVGKGAFGSAVLYR----RREDSSLVIIKEINM----YDLDSSQRR--LALNEV 219
Query: 66 YFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXT-EQTTCFIILQVC 124
LS + P I YY +F + L I MEY E+ +++Q+C
Sbjct: 220 SLLSRIEHPNIIAYYDSFEEEGVLMIEMEYADGGTLAQMLSRTQNLLDEEQIGDMMIQMC 279
Query: 125 HALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPF 184
A+ YLHE ++HRDLK AN+ L D V++ D G++ + + G K T VGTP+
Sbjct: 280 SAVAYLHENSVLHRDLKTANVFLTRDSFVKIGDFGISKIMGTETLAQGAK---TVVGTPY 336
Query: 185 WMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRNMD 244
+++PE+ SY+ K D+W+LG E+ K D++ AL+ A + ++
Sbjct: 337 YISPEMCSGVSYNEKSDMWALGCILYEMCCLKKAFEG-DNLPALVNSIMTCAYTPVKG-P 394
Query: 245 ISPLGKDFIRSCLQQDPNQRPTCKQLLQ 272
S K IR LQ DP +RP+ Q L+
Sbjct: 395 YSAEMKMVIRELLQLDPQKRPSAPQALK 422
>At2g34180 [T] KOG0583 Serine/threonine protein kinase
Length = 502
Score = 107 bits (267), Expect = 4e-23
Identities = 79/281 (28%), Positives = 127/281 (45%), Gaps = 27/281 (9%)
Query: 4 LQQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEH--SNEPIDLL 61
+ ++++ + +G G+F VYLA + S ++ +AIK I+ E + +
Sbjct: 54 MDKYEIGKLLGHGSFAKVYLARNIHSGED-----------VAIKVIDKEKIVKSGLAGHI 102
Query: 62 LKEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIIL 121
+EI L + PYI H +YIVMEY E T
Sbjct: 103 KREISILRRVRHPYIVHLLEVMATKTKIYIVMEYVRGGELYNTVARGRLR-EGTARRYFQ 161
Query: 122 QVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLG---VTGQLKFNSTRHGGKNLNT 178
Q+ ++ + H + + HRDLK N+LL+D G V+++D G V+ QLK T
Sbjct: 162 QLISSVAFCHSRGVYHRDLKLENLLLDDKGNVKVSDFGLSVVSEQLKQEGI------CQT 215
Query: 179 FVGTPFWMAPEIIKNQSYDG-KCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNAD 237
F GTP ++APE++ + Y+G K DIWS G+ L+ G P D L+ K+
Sbjct: 216 FCGTPAYLAPEVLTRKGYEGAKADIWSCGVILFVLMAGYLP---FDDKNILVMYTKIYKG 272
Query: 238 SILRNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKK 278
SP + L +P+ R T ++++H+W KK
Sbjct: 273 QFKCPKWFSPELARLVTRMLDTNPDTRITIPEIMKHRWFKK 313
>YOL016c [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 447
Score = 107 bits (266), Expect = 5e-23
Identities = 84/289 (29%), Positives = 136/289 (46%), Gaps = 31/289 (10%)
Query: 13 VGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCI---NLEHSNEPIDLLLKEIYFLS 69
+G G+FG V A L +N++ +AIK + L+ +N + +L +E+ L
Sbjct: 53 LGAGSFGVVRQARKLSTNED-----------VAIKILLKKALQGNNVQLQMLYEELSILQ 101
Query: 70 TLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVCHALEY 129
L P I + F YIV + + TE II+Q+ A+EY
Sbjct: 102 KLSHPNIVSFKDWFESKDKFYIVTQLATGGELFDRILSRGKFTEVDAVEIIVQILGAVEY 161
Query: 130 LHEKRLIHRDLKAANILLNDDGE---VRLADLGVTGQLKFNSTRHGGKNL-NTFVGTPFW 185
+H K ++HRDLK N+L D E + +AD G+ QLK G ++L G+ +
Sbjct: 162 MHSKNVVHRDLKPENVLYVDKSENSPLVIADFGIAKQLK------GEEDLIYKAAGSLGY 215
Query: 186 MAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRNM-- 243
+APE++ + CDIWS+G+ T LL G P +S++ M + + +M
Sbjct: 216 VAPEVLTQDGHGKPCDIWSIGVITYTLLCGYSPFI-AESVEGFMEECTASRYPVTFHMPY 274
Query: 244 --DISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWL--KKCSITNIMEEI 288
+IS K FI L+ +P RPT +LL W+ K+ +NI+ ++
Sbjct: 275 WDNISIDVKRFILKALRLNPADRPTATELLDDPWITSKRVETSNILPDV 323
>Hs4502023 [T] KOG0690 Serine/threonine protein kinase
Length = 481
Score = 107 bits (266), Expect = 5e-23
Identities = 70/291 (24%), Positives = 130/291 (44%), Gaps = 22/291 (7%)
Query: 2 LSLQQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLL 61
+++ F L+ +GKG FG V L + + + K V +A + +
Sbjct: 147 VTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIA---------KDEVAHT 197
Query: 62 LKEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIIL 121
+ E L P++T F L VMEY + TE+ F
Sbjct: 198 VTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGA 257
Query: 122 QVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVG 181
++ ALEYLH + +++RD+K N++L+ DG +++ D G+ G + TF G
Sbjct: 258 EIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLC-----KEGISDGATMKTFCG 312
Query: 182 TPFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILR 241
TP ++APE++++ Y D W LG+ E++ G+ P + D + I + I
Sbjct: 313 TPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELI---LMEEIRF 369
Query: 242 NMDISPLGKDFIRSCLQQDPNQR-----PTCKQLLQHKWLKKCSITNIMEE 287
+SP K + L++DP QR K++++H++ + +++++
Sbjct: 370 PRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQK 420
>Hs19424132 [D] KOG0591 NIMA (never in mitosis)-related G2-specific
serine/threonine protein kinase
Length = 302
Score = 107 bits (266), Expect = 5e-23
Identities = 81/283 (28%), Positives = 125/283 (43%), Gaps = 49/283 (17%)
Query: 3 SLQQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLL- 61
+L F++ + +G+G F +VY A L VP+A+K + + DL+
Sbjct: 30 TLANFRIEKKIGRGQFSEVYRAACLLDG-----------VPVALKKVQI------FDLMD 72
Query: 62 -------LKEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXT-- 112
+KEI L L+ P + YY +F D L IV+E
Sbjct: 73 AKARADCIKEIDLLKQLNHPNVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRL 132
Query: 113 --EQTTCFIILQVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTR 170
E+T +Q+C ALE++H +R++HRD+K AN+ + G V+L DLG+ +T
Sbjct: 133 IPERTVWKYFVQLCSALEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTA 192
Query: 171 HGGKNLNTFVGTPFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMR 230
++ VGTP++M+PE I Y+ K DIWSLG E+ + P + D M
Sbjct: 193 -----AHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPF-YGDKMNLYSL 246
Query: 231 IPKLNADSILRNMDISPLGKD--------FIRSCLQQDPNQRP 265
K + D PL D + C+ DP +RP
Sbjct: 247 CKK------IEQCDYPPLPSDHYSEELRQLVNMCINPDPEKRP 283
>At5g40440 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 520
Score = 107 bits (266), Expect = 5e-23
Identities = 79/245 (32%), Positives = 115/245 (46%), Gaps = 10/245 (4%)
Query: 38 IPKNVPLAIKCINLEHSNEPIDLLLKEIYFLSTLHCPY-ITHYYGTFTGDCN--LYIVME 94
IP + LA+K IN+ E LL EI L C + ++G F + + I +E
Sbjct: 103 IPNHRILALKKINI-FEREKRQQLLTEIRTLCEAPCHEGLVDFHGAFYSPDSGQISIALE 161
Query: 95 YCSXXXXXXXXXXXXXXTEQTTCFIILQVCHALEYLHEKR-LIHRDLKAANILLNDDGEV 153
Y + E + ++ L YLH R L+HRD+K AN+L+N GE
Sbjct: 162 YMNGGSLADILKVTKKIPEPVLSSLFHKLLQGLSYLHGVRHLVHRDIKPANLLINLKGEP 221
Query: 154 RLADLGVTGQLKFNSTRHGGKNLNTFVGTPFWMAPEIIKNQSYDGKCDIWSLGITTLELL 213
++ D G++ L+ + TFVGT +M+PE I+N SY DIWSLG+ E
Sbjct: 222 KITDFGISAGLENSMAMCA-----TFVGTVTYMSPERIRNDSYSYPADIWSLGLALFECG 276
Query: 214 NGKPPMSHLDSMKALMRIPKLNADSILRNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQH 273
G+ P + LM + + SP FI +CLQ+DP+ RPT QLL H
Sbjct: 277 TGEFPYIANEGPVNLMLQILDDPSPTPPKQEFSPEFCSFIDACLQKDPDARPTADQLLSH 336
Query: 274 KWLKK 278
++ K
Sbjct: 337 PFITK 341
>7302861 [T] KOG0696 Serine/threonine protein kinase
Length = 700
Score = 107 bits (266), Expect = 5e-23
Identities = 80/266 (30%), Positives = 118/266 (44%), Gaps = 20/266 (7%)
Query: 1 MLSLQQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDL 60
M+ F ++ +GKG+FG V LA G+++ + K+V + + L + + I
Sbjct: 365 MIRAADFNFVKVIGKGSFGKVLLAERRGTDELYAVKVLRKDVIIQTDDMELPMNEKKILA 424
Query: 61 LLKEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFII 120
L FL ++H + T L+ VMEYC E F
Sbjct: 425 LSGRPPFLVSMHSCFQTMD--------RLFFVMEYCKGGDLMYHMQQYGRFKESVAIFYA 476
Query: 121 LQVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVT--GQLKFNSTRHGGKNLNT 178
++V AL +LHE+ +I+RDLK NILL+ +G V+L D G++ G + +TR T
Sbjct: 477 VEVAIALFFLHERDIIYRDLKLDNILLDGEGHVKLVDFGLSKEGVTERQTTR-------T 529
Query: 179 FVGTPFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADS 238
F GTP +MAPEI+ Y D WS G+ E + G+ P D I A
Sbjct: 530 FCGTPNYMAPEIVSYDPYSIAADWWSFGVLLFEFMAGQAPFEGDDETTVFRNIKDKKA-- 587
Query: 239 ILRNMDISPLGKDFIRSCLQQDPNQR 264
+ S D I S L + PN R
Sbjct: 588 -VFPKHFSVEAMDIITSFLTKKPNNR 612
>7299437 [R] KOG0586 Serine/threonine protein kinase
Length = 604
Score = 107 bits (266), Expect = 5e-23
Identities = 79/277 (28%), Positives = 130/277 (46%), Gaps = 32/277 (11%)
Query: 7 FQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPI-DLLLKEI 65
+++++ +GKGNF V LA +L + +E +AIK I+ N L +E+
Sbjct: 63 YKIIKTLGKGNFAKVKLAIHLPTGRE-----------VAIKLIDKTALNTIARQKLYREV 111
Query: 66 YFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVCH 125
+ L+ P I + LY+VMEY S E+ + Q+
Sbjct: 112 NIMKKLNHPNIVRLLQVIESERTLYLVMEYVSGGELFNYLVKNGRMRERDARVLFRQLVS 171
Query: 126 ALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFW 185
A+EY H K ++HRDLKA N+LL+ ++++AD G F++T L TF G+P +
Sbjct: 172 AIEYCHSKSIVHRDLKAENLLLDQQMKLKIADFG------FSTTFEPKAPLETFCGSPPY 225
Query: 186 MAPEIIKNQSYDG-KCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRN-- 242
APE+ + + Y G + D WSLG+ L++G P ++K L D +LR
Sbjct: 226 AAPELFRGKKYSGPEVDSWSLGVVLYTLVSGSLPFDG-TNLKEL-------RDRVLRGKY 277
Query: 243 ---MDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWL 276
+S + IR L +P QR + ++ +W+
Sbjct: 278 RVPYYVSIECESLIRKFLVLNPTQRTSLSAVMADRWI 314
>CE29092 [T] KOG0694 Serine/threonine protein kinase
Length = 707
Score = 106 bits (265), Expect = 7e-23
Identities = 79/274 (28%), Positives = 132/274 (47%), Gaps = 32/274 (11%)
Query: 2 LSLQQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLA---IKCINLEHSNEPI 58
LS+ F ++ +GKG+FG V LA G+++ + K+V + ++C E
Sbjct: 373 LSIHDFTFMKVLGKGSFGKVMLAERKGTDEVYAIKILKKDVIVQDDDVECTMCE------ 426
Query: 59 DLLLKEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCF 118
K I L+ H P++T + +F L+ VMEY + E F
Sbjct: 427 ----KRILSLAAKH-PFLTALHSSFQTSDRLFFVMEYVNGGDLMFQIQRARKFDESRARF 481
Query: 119 IILQVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGV--TGQLKFNSTRHGGKNL 176
+V AL++LH +I+RDLK NILL+ +G RLAD G+ G K N T
Sbjct: 482 YAAEVTCALQFLHRNDVIYRDLKLDNILLDAEGHCRLADFGMCKEGINKDNLT------- 534
Query: 177 NTFVGTPFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPM---SHLDSMKALMRIPK 233
+TF GTP ++APEI++ Y D W+LG+ E++ G+PP + D +A++
Sbjct: 535 STFCGTPDYIAPEILQEMEYGVSVDWWALGVLMYEMMAGQPPFEADNEDDLFEAILN--- 591
Query: 234 LNADSILRNMDISPLGKDFIRSCLQQDPNQRPTC 267
D +L + +S + +++ + ++ +R C
Sbjct: 592 ---DDVLYPVWLSKEAVNILKAFMTKNAGKRLGC 622
>CE05780 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 336
Score = 106 bits (265), Expect = 7e-23
Identities = 81/301 (26%), Positives = 127/301 (41%), Gaps = 37/301 (12%)
Query: 5 QQFQLLECVGKGNFGDVYL-------------AHYLGSNQEPTDPKIPKNV---PLAIKC 48
+Q+++ +GKGNF V+L Y + Q K + V + KC
Sbjct: 55 KQYEIGAIIGKGNFSSVHLTRRKEDGTKCALKVRYQSTLQFSFPSKFFQQVEKRAMRGKC 114
Query: 49 INLEHSNEPIDLLLKEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXX 108
+++ E+ LS + +I F+ + +IV E+
Sbjct: 115 FFVDN----------EVEMLSLIQHDHIISIIDAFSTENQYFIVFEHAQYGDLYETIRKN 164
Query: 109 XXXTEQTTCFIILQVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNS 168
E I LQV AL YLHE+ ++HRD+K N+LL D V+L D G+
Sbjct: 165 GRIEEPDAAIITLQVASALNYLHERNVVHRDVKPENLLLVDKFSVKLCDFGL-------- 216
Query: 169 TRHGGKNLNTFVGTPFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMK-- 226
H L GTP + APE+++ Y +CDIWSLG+ +L G P D +
Sbjct: 217 ACHILGPLYRICGTPTYCAPEVLRETGYSTRCDIWSLGVVLYVMLVGYAPFRAPDQTRLF 276
Query: 227 ALMRIPKLNADSILRNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKKCSITNIME 286
L+ K N D + IS KD + + + +RP Q++ H W+ ++ NI +
Sbjct: 277 KLIMQAKPNLD-MPEWKGISLKAKDLVSRLMNKTEERRPLASQIMAHPWIAPYTMENIDD 335
Query: 287 E 287
E
Sbjct: 336 E 336
>7302860 [T] KOG0696 Serine/threonine protein kinase
Length = 679
Score = 106 bits (265), Expect = 7e-23
Identities = 79/267 (29%), Positives = 121/267 (44%), Gaps = 16/267 (5%)
Query: 1 MLSLQQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDL 60
M+ F ++ +GKG+FG V LA GS +E KI K K + ++ + +
Sbjct: 344 MIRATDFNFIKVLGKGSFGKVLLAERKGS-EELYAIKILK------KDVIIQDDDVECTM 396
Query: 61 LLKEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFII 120
+ K + L P++ + F L+ VMEY + E F
Sbjct: 397 IEKRVLALGEKP-PFLVQLHSCFQTMDRLFFVMEYVNGGDLMFQIQQFGKFKEPVAVFYA 455
Query: 121 LQVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFV 180
++ L +LH K +++RDLK N+LL+ DG V++AD G+ K N G K TF
Sbjct: 456 AEIAAGLFFLHTKGILYRDLKLDNVLLDADGHVKIADFGM---CKENIV--GDKTTKTFC 510
Query: 181 GTPFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSIL 240
GTP ++APEII Q Y D W+ G+ E+L G+PP D + I N +
Sbjct: 511 GTPDYIAPEIILYQPYGKSVDWWAYGVLLYEMLVGQPPFDGEDEEELFAAITDHN---VS 567
Query: 241 RNMDISPLGKDFIRSCLQQDPNQRPTC 267
+S K+ + L + PN+R C
Sbjct: 568 YPKSLSKEAKEACKGFLTKQPNKRLGC 594
>CE26793_1 [R] KOG0611 Predicted serine/threonine protein kinase
Length = 795
Score = 106 bits (265), Expect = 7e-23
Identities = 86/296 (29%), Positives = 129/296 (43%), Gaps = 29/296 (9%)
Query: 6 QFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDL--LLK 63
+F++ + +G G +G V LA+ D K + V A+K I DL + +
Sbjct: 74 RFEITKKLGSGTYGKVSLAY---------DHKFDREV--AVKLIKKSAIESKADLVRIRR 122
Query: 64 EIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQV 123
EI +S L+ P I Y F + +VMEY S E I Q+
Sbjct: 123 EIRIMSALNHPNIIQIYEVFENKDKIILVMEYSSGGELYDYVSRCGSLPEAEARRIFRQI 182
Query: 124 CHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKN-LNTFVGT 182
A+ Y H+ R+ HRDLK NILL+ + ++AD G+ S KN L TF G+
Sbjct: 183 TSAVLYCHKHRVAHRDLKLENILLDQNNNAKIADFGL-------SNYFADKNLLTTFCGS 235
Query: 183 PFWMAPEIIKNQSYDG-KCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILR 241
P + +PEII Y G + D WSLGI L+ G P D + + +I +
Sbjct: 236 PLYASPEIINGTPYKGPEVDCWSLGILLYTLVYGSMPFDGRDFNRMVRQIKR----GAYF 291
Query: 242 NMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKKCSITNIMEEITVMKTNQIL 297
+ IR+ L+ +P +R T + H WL ++ M I + NQI+
Sbjct: 292 EPETPSTASMLIRNMLRVNPERRATIFDIASHWWL---NLEENMPVIQELPENQII 344
>YNR047w [R] KOG0610 Putative serine/threonine protein kinase
Length = 893
Score = 106 bits (264), Expect = 9e-23
Identities = 87/307 (28%), Positives = 136/307 (43%), Gaps = 46/307 (14%)
Query: 1 MLSLQQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEH--SNEPI 58
M+ Q F+ + +G+G+ G V+L +N+ A+K ++ + I
Sbjct: 490 MVGPQSFEKIRLLGQGDVGKVFLVREKKTNRV-----------YALKVLSKDEMIKRNKI 538
Query: 59 DLLLKEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTC- 117
+L E L+T + P+I Y +F + LY+ MEYC T +T C
Sbjct: 539 KRVLTEQEILATSNHPFIVTLYHSFQSEDYLYLCMEYCMGGEFFRALQ-----TRKTKCI 593
Query: 118 ------FIILQVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTR- 170
F +V ALEYLH I+RDLK NILL+ G + L+D ++ Q K +
Sbjct: 594 CEDDARFYASEVTAALEYLHLLGFIYRDLKPENILLHQSGHIMLSDFDLSIQAKDSKVPV 653
Query: 171 ---------------HGGKNLNTFVGTPFWMAPEIIKNQSYDGKCDIWSLGITTLELLNG 215
G N+FVGT ++APE+I+ + D W+LGI E+L G
Sbjct: 654 VKGSAQSTLVDTKICSDGFRTNSFVGTEEYIAPEVIRGNGHTAAVDWWTLGILIYEMLFG 713
Query: 216 KPPMSHLDSMKALMRIPKLNADSILRNMDISPLGKDFIRSCLQQDPNQRPTCK----QLL 271
P ++ + I K N S N +IS KD I+ L ++ ++R CK +
Sbjct: 714 FTPFKGDNTNETFTNILK-NEVSFPNNNEISRTCKDLIKKLLTKNESKRLGCKMGAADVK 772
Query: 272 QHKWLKK 278
+H + KK
Sbjct: 773 KHPFFKK 779
>SPAC1B9.02c [RT] KOG0598 Ribosomal protein S6 kinase and related proteins
Length = 696
Score = 106 bits (264), Expect = 9e-23
Identities = 77/262 (29%), Positives = 127/262 (48%), Gaps = 16/262 (6%)
Query: 5 QQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKE 64
+ F L +GKG FG VYL +N+ KI K L ++ + H+ ++L++
Sbjct: 300 EDFTALRLIGKGTFGQVYLVRKNDTNRIYAMKKISKK--LIVRKKEVTHTLGERNILVRT 357
Query: 65 IYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVC 124
S P+I +F +LY++ +Y S EQ F I ++
Sbjct: 358 ----SLDESPFIVGLKFSFQTASDLYLITDYMSGGELFWHLQHEGRFPEQRAKFYIAELV 413
Query: 125 HALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVT-GQLKFNSTRHGGKNLNTFVGTP 183
ALE+LH+ +I+RDLK NILL+ DG + L D G++ L N+T NTF GT
Sbjct: 414 LALEHLHKHDIIYRDLKPENILLDADGHIALCDFGLSKANLSANAT------TNTFCGTT 467
Query: 184 FWMAPEI-IKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRN 242
++APE+ ++++ Y + D WSLG+ E+ G P + ++ + R +
Sbjct: 468 EYLAPEVLLEDKGYTKQVDFWSLGVLVFEMCCGWSPF-YAPDVQQMYRNIAFGKVRFPKG 526
Query: 243 MDISPLGKDFIRSCLQQDPNQR 264
+ +S G+ F+R L ++PN R
Sbjct: 527 V-LSSEGRSFVRGLLNRNPNHR 547
>Hs20550407 [T] KOG0201 Serine/threonine protein kinase
Length = 112
Score = 106 bits (264), Expect = 9e-23
Identities = 49/92 (53%), Positives = 66/92 (71%), Gaps = 5/92 (5%)
Query: 119 IILQVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNT 178
I+ ++ L+YLH ++ IHR +KAAN+LL++ EV+L D G+ GQL T+ NT
Sbjct: 26 ILREILKGLDYLHSEKKIHRGVKAANVLLSEHCEVKLVDFGMAGQLADTQTKR-----NT 80
Query: 179 FVGTPFWMAPEIIKNQSYDGKCDIWSLGITTL 210
FVGTPFW+APE+IK +YD K DIWSLGITT+
Sbjct: 81 FVGTPFWIAPEVIKQSAYDSKADIWSLGITTI 112
>CE21025 [D] KOG0580 Serine/threonine protein kinase
Length = 326
Score = 106 bits (264), Expect = 9e-23
Identities = 79/280 (28%), Positives = 134/280 (47%), Gaps = 25/280 (8%)
Query: 3 SLQQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLL 62
SL F + +GKG FG+V++ S ++ T I V + + L S++ L
Sbjct: 40 SLDDFDVGRPLGKGKFGNVFI-----SREKKTKRIIALKVLFKTQLLQLGVSHQ----LK 90
Query: 63 KEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXX--XXXTEQTTCFII 120
+EI L P I YG F D ++++++Y S E +
Sbjct: 91 REIEIQYHLRHPNILTLYGYFHDDKRVFVILDYASRGELFNVLQSQPGHKVNEVIAGRFV 150
Query: 121 LQVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFV 180
Q+ +AL Y H K +IHRD+K N+LL+ ++LAD G + + +S RH T
Sbjct: 151 RQLANALHYCHSKGVIHRDIKPENLLLDSKLNLKLADFGWS-VVADHSKRH------TLC 203
Query: 181 GTPFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIP--KLNADS 238
GT ++APE++ NQ +D DIW++GI E+L G P ++ K + RI K+ S
Sbjct: 204 GTMDYLAPEMVSNQPHDFNVDIWAIGILLFEMLVGYAPFANQTGDKLIARIKECKIYIPS 263
Query: 239 ILRNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKK 278
++ + S I + ++++P +R ++ H W+K+
Sbjct: 264 VVTDGAAS-----LINAIIKKEPQERLPLVDIMAHPWIKE 298
>At5g62310 [TR] KOG0606 Microtubule-associated serine/threonine kinase and
related proteins
Length = 1168
Score = 106 bits (264), Expect = 9e-23
Identities = 80/290 (27%), Positives = 130/290 (44%), Gaps = 39/290 (13%)
Query: 3 SLQQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLL 62
S++ F++++ + +G FG V+LA + + K+ K + K ++ +L
Sbjct: 750 SIEDFEIIKPISRGAFGRVFLAKKRATG-DLFAIKVLKKADMIRK--------NAVESIL 800
Query: 63 KEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQ 122
E L ++ P++ ++ +FT NLY+VMEY + E I +
Sbjct: 801 AERNILISVRNPFVVRFFYSFTCRENLYLVMEYLNGGDLFSLLRNLGCLDEDMARIYIAE 860
Query: 123 VCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNST------------- 169
V ALEYLH +IHRDLK N+L+N DG ++L D G++ NST
Sbjct: 861 VVLALEYLHSVNIIHRDLKPDNLLINQDGHIKLTDFGLSKVGLINSTDDLSGESSLGNSG 920
Query: 170 ---------RHG----GKNLNTFVGTPFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGK 216
+H + + VGTP ++APEI+ + D WS+G+ E+L G
Sbjct: 921 FFAEDGSKAQHSQGKDSRKKHAVVGTPDYLAPEILLGMGHGKTADWWSVGVILFEVLVGI 980
Query: 217 PPMSHLDSMKALMRIPKLNADSILRNM--DISPLGKDFIRSCLQQDPNQR 264
PP + + I +N D N+ +IS D I L ++P QR
Sbjct: 981 PPFNAETPQQIFENI--INRDIPWPNVPEEISYEAHDLINKLLTENPVQR 1028
>At2g32510 [T] KOG0198 MEKK and related serine/threonine protein kinases
Length = 372
Score = 106 bits (264), Expect = 9e-23
Identities = 76/276 (27%), Positives = 131/276 (46%), Gaps = 37/276 (13%)
Query: 13 VGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEIYFLSTLH 72
+G+G+ VY A G N + LA+K + S + L +E LS+L
Sbjct: 9 LGRGSTATVYAA--AGHNSDEI---------LAVKSSEVHRS----EFLQREAKILSSLS 53
Query: 73 CPYITHYYGTFT-----GDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQ-VCHA 126
PY+ Y G+ T G ++MEY ++T + +
Sbjct: 54 SPYVIGYRGSETKRESNGVVMYNLLMEYAPYGTLTDAAAKDGGRVDETRVVKYTRDILKG 113
Query: 127 LEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLK--FNSTRHGGKNLNTFVGTPF 184
LEY+H K ++H D+K +N+++++ GE ++AD G ++ F S +GTP
Sbjct: 114 LEYIHSKGIVHCDVKGSNVVISEKGEAKIADFGCAKRVDPVFESP---------VMGTPA 164
Query: 185 WMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDS----MKALMRIPKLNADSIL 240
+MAPE+ + + + DIW++G T +E++ G PP + DS + L R+ + L
Sbjct: 165 FMAPEVARGEKQGKESDIWAVGCTMIEMVTGSPPWTKADSREDPVSVLYRVGYSSETPEL 224
Query: 241 RNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWL 276
+ ++ KDF+ CL+++ N+R T QLL H +L
Sbjct: 225 PCL-LAEEAKDFLEKCLKREANERWTATQLLNHPFL 259
>At1g49180_1 [OUT] KOG0595 Serine/threonine-protein kinase involved in autophagy
Length = 225
Score = 106 bits (264), Expect = 9e-23
Identities = 64/195 (32%), Positives = 98/195 (49%), Gaps = 10/195 (5%)
Query: 46 IKCINLEHSNEPI-DLLLKEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXX 104
+KC +L N + D L E+ FLS++ P I D L +V+EYC
Sbjct: 33 MKCFDLSKLNRNLRDCLNNELEFLSSVDHPNIIRLLHVSQDDDFLVMVLEYCDGGTLSSY 92
Query: 105 XXXXXXXTEQTTCFIILQVCHALEYLHEKRLIHRDLKAANILLNDDGE---VRLADLGVT 161
E + Q+ LE +H+ +IHRDLK NIL++ G+ +++AD +
Sbjct: 93 IQRYGRVEEDIAKRFMKQIGAGLEIIHDNHIIHRDLKPENILIDGSGDDLVLKIADFSLA 152
Query: 162 GQLKFNSTRHGGKNLNTFVGTPFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSH 221
+L H GK L T G+PF+MAPE+++ Q Y+ K D+WS+G ELL+G PP
Sbjct: 153 RKL------HPGKYLETVCGSPFYMAPEVLQFQRYNEKADMWSVGAILFELLHGYPPFRG 206
Query: 222 LDSMKALMRIPKLNA 236
++++ L I A
Sbjct: 207 NNNVQVLRNIKSSTA 221
>YMR104c [RT] KOG0598 Ribosomal protein S6 kinase and related proteins
Length = 677
Score = 105 bits (263), Expect = 1e-22
Identities = 98/360 (27%), Positives = 155/360 (42%), Gaps = 43/360 (11%)
Query: 2 LSLQQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLL 61
LS+ F LL+ +GKG+FG V + Q+ K + + KC + H+
Sbjct: 339 LSIDDFDLLKVIGKGSFGKVMQVRKKDT-QKIYALKALRKAYIVSKC-EVTHT------- 389
Query: 62 LKEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIIL 121
L E L+ + CP+I +F LY+V+ + + + + F I
Sbjct: 390 LAERTVLARVDCPFIVPLKFSFQSPEKLYLVLAFINGGELFYHLQHEGRFSLARSRFYIA 449
Query: 122 QVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVG 181
++ AL+ LH+ +I+RDLK NILL+ G + L D G+ K N + +TF G
Sbjct: 450 ELLCALDSLHKLDVIYRDLKPENILLDYQGHIALCDFGLC---KLNMKDND--KTDTFCG 504
Query: 182 TPFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILR 241
TP ++APEI+ Q Y D W+LGI E++ G PP + D +M K+ +L
Sbjct: 505 TPEYLAPEILLGQGYTKTVDWWTLGILLYEMMTGLPP--YYDENVPVM-YKKILQQPLLF 561
Query: 242 NMDISPLGKDFIRSCLQQDPNQR------------PTCKQLLQHKWLKKCSITN----IM 285
P KD + L +DP++R P K + K L K I +
Sbjct: 562 PDGFDPAAKDLLIGLLSRDPSRRLGVNGTDEIRNHPFFKDISWKKLLLKGYIPPYKPIVK 621
Query: 286 EEITVMKTNQILSKEKPRSCKPRFPLSDKVYKTNLPNQLESWRFEDESVLRFDGLGDIPN 345
EI +Q +KEKP + D+ ++ Q W + + + LGD P+
Sbjct: 622 SEIDTANFDQEFTKEKPID-----SVVDEYLSASIQKQFGGWTYIGD-----EQLGDSPS 671
>Hs4885061 [T] KOG0690 Serine/threonine protein kinase
Length = 480
Score = 105 bits (263), Expect = 1e-22
Identities = 73/280 (26%), Positives = 127/280 (45%), Gaps = 23/280 (8%)
Query: 2 LSLQQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLL 61
+++ +F+ L+ +GKG FG V L + + + K V +A + +
Sbjct: 145 VTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVA---------KDEVAHT 195
Query: 62 LKEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIIL 121
L E L P++T +F L VMEY + +E F
Sbjct: 196 LTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGA 255
Query: 122 QVCHALEYLH-EKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFV 180
++ AL+YLH EK +++RDLK N++L+ DG +++ D G+ + G + TF
Sbjct: 256 EIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKE-----GIKDGATMKTFC 310
Query: 181 GTPFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSIL 240
GTP ++APE++++ Y D W LG+ E++ G+ P + D K I + I
Sbjct: 311 GTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELI---LMEEIR 367
Query: 241 RNMDISPLGKDFIRSCLQQDPNQR-----PTCKQLLQHKW 275
+ P K + L++DP QR K+++QH++
Sbjct: 368 FPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRF 407
>CE25046 [T] KOG0032 Ca2+/calmodulin-dependent protein kinase EF-Hand
protein superfamily
Length = 348
Score = 105 bits (263), Expect = 1e-22
Identities = 76/276 (27%), Positives = 123/276 (44%), Gaps = 21/276 (7%)
Query: 5 QQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKE 64
+++ + +G G F V+LA + K A+KCI+ + + L E
Sbjct: 20 EKYDFRDVLGTGAFSKVFLA----------ESKSDAGQMYAVKCIDKKALKGKEESLENE 69
Query: 65 IYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVC 124
I L L I + T+ +Y+VME + TEQ +I QV
Sbjct: 70 IKVLRKLRHNNIVQLFDTYDEKQFVYLVMELVTGGELFDRIVAKGSYTEQDASNLIRQVL 129
Query: 125 HALEYLHEKRLIHRDLKAANILL---NDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVG 181
A+ ++H+ ++HRDLK N+L ++D ++ ++D G+ + T G + T G
Sbjct: 130 EAVGFMHDNGVVHRDLKPENLLYYNQDEDSKIMISDFGL------SKTEDSGV-MATACG 182
Query: 182 TPFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILR 241
TP ++APE+++ + Y D+WS+G+ LL G PP +I K +
Sbjct: 183 TPGYVAPEVLQQKPYGKAVDVWSIGVIAYILLCGYPPFYDESDANLFAQIIKGEYEFDAP 242
Query: 242 NMD-ISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWL 276
D IS KDFI + DP R TC+ L H W+
Sbjct: 243 YWDQISDSAKDFITHLMCCDPEARFTCQDALSHPWI 278
>YGL179c [T] KOG0585 Ca2+/calmodulin-dependent protein kinase kinase beta
and related serine/threonine protein kinases
Length = 560
Score = 105 bits (262), Expect = 2e-22
Identities = 93/340 (27%), Positives = 144/340 (42%), Gaps = 49/340 (14%)
Query: 4 LQQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLK 63
L F++L +G G +G V LA LG+ +AIK +N L LK
Sbjct: 47 LNNFEILATLGNGQYGKVKLARDLGTG-----------ALVAIKILNRFEKRSGYSLQLK 95
Query: 64 --------EIYFLSTLHCPYITHYYGTFTG--DCNLYIVMEYCSXX--------XXXXXX 105
EI + H + Y +Y+V+EYCS
Sbjct: 96 VENPRVNQEIEVMKRCHHENVVELYEILNDPESTKVYLVLEYCSRGPVKWCPENKMEIKA 155
Query: 106 XXXXXXTEQTTCFIILQVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGV----- 160
T Q + ++L V LEYLH + + HRD+K +N+L++ +G V+++D GV
Sbjct: 156 VGPSILTFQQSRKVVLDVVSGLEYLHSQGITHRDIKPSNLLISSNGTVKISDFGVAMSTA 215
Query: 161 TGQLKFNSTRHGGKNLNTFVGTPFWMAPEII---KNQSYDGKCDIWSLGITTLELLNGKP 217
TG S+ H + +GTP + APE+ K S DIWSLG+T LL GK
Sbjct: 216 TGSTNIQSS-HEQLLKSRALGTPAFFAPELCSTEKEYSCSSAIDIWSLGVTIYCLLFGKL 274
Query: 218 PM---SHLDSMKALMRIP--------KLNADSILRNMDISPLGKDFIRSCLQQDPNQRPT 266
P S L+ +++ P LN + M+ KD ++ LQ+DP++R
Sbjct: 275 PFNANSGLELFDSIINKPLEFPSYEEMLNGATSGITMEEYTDAKDLLKKLLQKDPDKRIK 334
Query: 267 CKQLLQHKWLKKCSITNIMEEITVMKTNQILSKEKPRSCK 306
+ H ++ ++ +T ++T L P SCK
Sbjct: 335 LADIKVHPFMCHYGKSDAASVLTNLETFHELKVSPPSSCK 374
>7300435 [T] KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and related
serine/threonine protein kinases
Length = 1612
Score = 105 bits (262), Expect = 2e-22
Identities = 82/294 (27%), Positives = 128/294 (42%), Gaps = 41/294 (13%)
Query: 13 VGKGNFGDVYLAHYLGSNQ---------EPTDPKIPKNVPLAIKCIN-LEHSNEPIDLLL 62
+G+G FG VY A + + +P + + KNV +K + ++H N
Sbjct: 1329 IGQGRFGKVYTAVNNNTGELMAMKEIAIQPGETRALKNVAEELKILEGIKHKN------- 1381
Query: 63 KEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQ 122
+ YYG L I ME CS E T Q
Sbjct: 1382 -------------LVRYYGIEVHREELLIFMELCSEGTLESLVELTGNLPEALTRRFTAQ 1428
Query: 123 VCHALEYLHEKRLIHRDLKAANILLND-DGEVRLADLGVTGQLKFNSTRHGGKNLNTFVG 181
+ + LH+ ++HRD+K ANI L D ++L D G +++ ++T G L +VG
Sbjct: 1429 LLSGVSELHKHGIVHRDIKTANIFLVDGSNSLKLGDFGSAVKIQAHTTVPG--ELQGYVG 1486
Query: 182 TPFWMAPEIIKNQSYDG---KCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADS 238
T +MAPE+ + DG DIWS+G +E+ +GK P + DS +M + +
Sbjct: 1487 TQAYMAPEVFTKTNSDGHGRAADIWSVGCVVVEMASGKRPWAQFDSNFQIMFKVGM-GEK 1545
Query: 239 ILRNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLK----KCSITNIMEEI 288
+S G DFI CLQ DP +R T +LL+H + K +CS + ++
Sbjct: 1546 PQAPESLSQEGHDFIDHCLQHDPKRRLTAVELLEHNFCKYGRDECSSEQLQMQV 1599
>HsM5454184 [T] KOG4721 Serine/threonine protein kinase contains leucine zipper
domain
Length = 859
Score = 105 bits (261), Expect = 2e-22
Identities = 79/280 (28%), Positives = 125/280 (44%), Gaps = 32/280 (11%)
Query: 10 LECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEIYFLS 69
L+ VG G G V+L + G +A+K + DL +I L
Sbjct: 128 LQWVGSGAQGAVFLGRFHGEE-------------VAVKKVR--------DLKETDIKHLR 166
Query: 70 TLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVCHALEY 129
L P I + G T I+ME+C+ T + + + Y
Sbjct: 167 KLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNY 226
Query: 130 LHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFWMAPE 189
LH ++IHRDLK+ N+L+ D V+++D G + +L ST+ +F GT WMAPE
Sbjct: 227 LHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKM------SFAGTVAWMAPE 280
Query: 190 IIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRNMDIS-PL 248
+I+N+ K DIWS G+ ELL G+ P +DS + + ++S+ + S P
Sbjct: 281 VIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGV---GSNSLHLPVPSSCPD 337
Query: 249 G-KDFIRSCLQQDPNQRPTCKQLLQHKWLKKCSITNIMEE 287
G K +R C P RP+ +Q+L H + + + +E
Sbjct: 338 GFKILLRQCWNSKPRNRPSFRQILLHLDIASADVLSTPQE 377
>Hs7662210 [OUT] KOG0595 Serine/threonine-protein kinase involved in autophagy
Length = 1036
Score = 105 bits (261), Expect = 2e-22
Identities = 79/282 (28%), Positives = 123/282 (43%), Gaps = 25/282 (8%)
Query: 6 QFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEI 65
++ + VG G F V+ G +++ TD ++ AIK IN ++ ++ LL KEI
Sbjct: 8 EYSKRDLVGHGAFAVVFR----GRHRQKTDWEV------AIKSINKKNLSKSQILLGKEI 57
Query: 66 YFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVCH 125
L L I Y ++++VMEYC+ +E T + Q+
Sbjct: 58 KILKELQHENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLHQIAA 117
Query: 126 ALEYLHEKRLIHRDLKAANILLN---------DDGEVRLADLGVTGQLKFNSTRHGGKNL 176
A+ LH K +IHRDLK NILL+ +++AD G L H
Sbjct: 118 AMRILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYL------HSNMMA 171
Query: 177 NTFVGTPFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNA 236
T G+P +MAPE+I +Q YD K D+WS+G + L GKPP M K +
Sbjct: 172 ATLCGSPMYMAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRS 231
Query: 237 DSILRNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKK 278
+ SP + + LQ++ R + H +L++
Sbjct: 232 LMPSIPRETSPYLANLLLGLLQRNQKDRMDFEAFFSHPFLEQ 273
>Hs4506737 [RT] KOG0598 Ribosomal protein S6 kinase and related proteins
Length = 525
Score = 105 bits (261), Expect = 2e-22
Identities = 69/229 (30%), Positives = 106/229 (46%), Gaps = 14/229 (6%)
Query: 7 FQLLECVGKGNFGDVYLAHYL-GSNQEPTDP-KIPKNVPLAIKCINLEHSNEPIDLLLKE 64
F+LL +GKG +G V+ + G+N K+ K + + H+ E
Sbjct: 91 FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKA-------E 143
Query: 65 IYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVC 124
L + P+I F LY+++EY S E T CF + ++
Sbjct: 144 RNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEIS 203
Query: 125 HALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPF 184
AL +LH+K +I+RDLK NI+LN G V+L D G+ + H G +TF GT
Sbjct: 204 MALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLC-----KESIHDGTVTHTFCGTIE 258
Query: 185 WMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPK 233
+MAPEI+ ++ D WSLG ++L G PP + + K + +I K
Sbjct: 259 YMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILK 307
>Hs21735552 [T] KOG4721 Serine/threonine protein kinase contains leucine zipper
domain
Length = 859
Score = 105 bits (261), Expect = 2e-22
Identities = 79/280 (28%), Positives = 125/280 (44%), Gaps = 32/280 (11%)
Query: 10 LECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEIYFLS 69
L+ VG G G V+L + G +A+K + DL +I L
Sbjct: 128 LQWVGSGAQGAVFLGRFHGEE-------------VAVKKVR--------DLKETDIKHLR 166
Query: 70 TLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVCHALEY 129
L P I + G T I+ME+C+ T + + + Y
Sbjct: 167 KLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNY 226
Query: 130 LHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFWMAPE 189
LH ++IHRDLK+ N+L+ D V+++D G + +L ST+ +F GT WMAPE
Sbjct: 227 LHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKM------SFAGTVAWMAPE 280
Query: 190 IIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRNMDIS-PL 248
+I+N+ K DIWS G+ ELL G+ P +DS + + ++S+ + S P
Sbjct: 281 VIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGV---GSNSLHLPVPSSCPD 337
Query: 249 G-KDFIRSCLQQDPNQRPTCKQLLQHKWLKKCSITNIMEE 287
G K +R C P RP+ +Q+L H + + + +E
Sbjct: 338 GFKILLRQCWNSKPRNRPSFRQILLHLDIASADVLSTPQE 377
>Hs15619015 [T] KOG0616 cAMP-dependent protein kinase catalytic subunit (PKA)
Length = 351
Score = 105 bits (261), Expect = 2e-22
Identities = 84/292 (28%), Positives = 127/292 (42%), Gaps = 29/292 (9%)
Query: 3 SLQQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPK--NVPLAIKCINLEHSNEPIDL 60
S QF+ L +G G+FG V L + QE K N +K +EH
Sbjct: 40 SSDQFERLRTLGMGSFGRVMLVRH----QETGGHYAMKILNKQKVVKMKQVEH------- 88
Query: 61 LLKEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFII 120
+L E L + P++ +F + LY+VMEY +E CF
Sbjct: 89 ILNEKRILQAIDFPFLVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPHACFYA 148
Query: 121 LQVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFV 180
QV A++YLH LIHRDLK N+L++ G +++ D G ++K + T
Sbjct: 149 AQVVLAVQYLHSLDLIHRDLKPENLLIDQQGYLQVTDFGFAKRVKGRTW--------TLC 200
Query: 181 GTPFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSIL 240
GTP ++APEII ++ Y+ D W+LG+ E+ G PP + + + K+ + +
Sbjct: 201 GTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAVGFPPFY---ADQPIQIYEKIVSGRVR 257
Query: 241 RNMDISPLGKDFIRSCLQQD-----PNQRPTCKQLLQHKWLKKCSITNIMEE 287
+S K +RS LQ D N R + HKW S I E+
Sbjct: 258 FPSKLSSDLKHLLRSLLQVDLTKRFGNLRNGVGDIKNHKWFATTSWIAIYEK 309
>CE04724 [T] KOG0983 Mitogen-activated protein kinase (MAPK) kinase
MKK7/JNKK2
Length = 505
Score = 105 bits (261), Expect = 2e-22
Identities = 77/280 (27%), Positives = 130/280 (45%), Gaps = 30/280 (10%)
Query: 4 LQQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLK 63
L++ Q +E +G G+ G V Y K+V +A+K + ++ + +L
Sbjct: 69 LKELQFVEDIGHGSCGTVTKCRY-------------KSVIMAVKTMPRTSNSYEMSRILM 115
Query: 64 EIYFLS-TLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQ 122
++ + + CPYI +G F + ++ + ME + E+ + +
Sbjct: 116 DLDVICLSFDCPYIVRCFGYFITNFDVRVCMECMATCLDRLLIRIKQPIPERIIGKLSVS 175
Query: 123 VCHALEYLHEK-RLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVG 181
+ AL YL K +++HRD+K +NILL+ G ++L D G+ G+L S H + G
Sbjct: 176 IIKALHYLKTKHQIMHRDVKPSNILLDWSGVIKLCDFGIAGRL-IESRAHSKQ-----AG 229
Query: 182 TPFWMAPEII---KNQSYDGKCDIWSLGITTLELLNGKPPM--SHLDSMKALMRIPKLNA 236
P +M PE + SYD + D+WS G+T +EL G+ P + D M ++
Sbjct: 230 CPLYMGPERLDPNNFDSYDIRSDVWSFGVTLVELATGQYPYAGTEFDMMSKILNDEPPRL 289
Query: 237 DSILRNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWL 276
D + D L + SCLQ+DP RP LLQH ++
Sbjct: 290 DPAKFSPDFCQL----VESCLQRDPTMRPNYDMLLQHPFV 325
>Hs21735544 [T] KOG0983 Mitogen-activated protein kinase (MAPK) kinase
MKK7/JNKK2
Length = 419
Score = 104 bits (260), Expect = 3e-22
Identities = 69/243 (28%), Positives = 121/243 (49%), Gaps = 14/243 (5%)
Query: 44 LAIKCINLEHSNEPIDLLLKEIYFLSTLH-CPYITHYYGTFTGDCNLYIVMEYCSXXXXX 102
+A+K + + E +L ++ + H CPYI +GTF + +++I ME
Sbjct: 146 IAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEK 205
Query: 103 XXXXXXXXXTEQTTCFIILQVCHALEYLHEKR-LIHRDLKAANILLNDDGEVRLADLGVT 161
E+ + + + AL YL EK +IHRD+K +NILL++ G+++L D G++
Sbjct: 206 LKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGIS 265
Query: 162 GQLKFNSTRHGGKNLNTFVGTPFWMAPEII-----KNQSYDGKCDIWSLGITTLELLNGK 216
G+L K G +MAPE I YD + D+WSLGI+ +EL G+
Sbjct: 266 GRLV------DSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQ 319
Query: 217 PPMSHLDS-MKALMRIPKLNADSILRNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKW 275
P + + + L ++ + + +M S + F++ CL +D +RP +LL+H +
Sbjct: 320 FPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSF 379
Query: 276 LKK 278
+K+
Sbjct: 380 IKR 382
>Hs4506101 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 438
Score = 104 bits (259), Expect = 3e-22
Identities = 77/273 (28%), Positives = 129/273 (47%), Gaps = 28/273 (10%)
Query: 5 QQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKE 64
Q + + +G GN G VY A++ +P LA+K I L+ + E ++ E
Sbjct: 164 QDIRYRDTLGHGNGGTVYKAYH-----------VPSGKILAVKVILLDITLELQKQIMSE 212
Query: 65 IYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVC 124
+ L YI +YG F + + I C+ E I + V
Sbjct: 213 LEILYKCDSSYIIGFYGAFFVENRISI----CTEFMDGGSLDVYRKMPEHVLGRIAVAVV 268
Query: 125 HALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPF 184
L YL +++HRD+K +N+L+N G+V+L D GV+ QL NS T+VGT
Sbjct: 269 KGLTYLWSLKILHRDVKPSNMLVNTRGQVKLCDFGVSTQL-VNSI------AKTYVGTNA 321
Query: 185 WMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADS-ILRNM 243
+MAPE I + Y D+WSLGI+ +E+ + + L ++ + ++ DS +L
Sbjct: 322 YMAPERISGEQYGIHSDVWSLGISFMEIQKNQGSLMPLQLLQCI-----VDEDSPVLPVG 376
Query: 244 DISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWL 276
+ S FI C+++ P +RP ++L+ H ++
Sbjct: 377 EFSEPFVHFITQCMRKQPKERPAPEELMGHPFI 409
>Hs21729897 [T] KOG0581 Mitogen-activated protein kinase kinase (MAP2K)
Length = 467
Score = 104 bits (259), Expect = 3e-22
Identities = 77/273 (28%), Positives = 129/273 (47%), Gaps = 28/273 (10%)
Query: 5 QQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKE 64
Q + + +G GN G VY A++ +P LA+K I L+ + E ++ E
Sbjct: 164 QDIRYRDTLGHGNGGTVYKAYH-----------VPSGKILAVKVILLDITLELQKQIMSE 212
Query: 65 IYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVC 124
+ L YI +YG F + + I C+ E I + V
Sbjct: 213 LEILYKCDSSYIIGFYGAFFVENRISI----CTEFMDGGSLDVYRKMPEHVLGRIAVAVV 268
Query: 125 HALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPF 184
L YL +++HRD+K +N+L+N G+V+L D GV+ QL NS T+VGT
Sbjct: 269 KGLTYLWSLKILHRDVKPSNMLVNTRGQVKLCDFGVSTQL-VNSI------AKTYVGTNA 321
Query: 185 WMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADS-ILRNM 243
+MAPE I + Y D+WSLGI+ +E+ + + L ++ + ++ DS +L
Sbjct: 322 YMAPERISGEQYGIHSDVWSLGISFMEIQKNQGSLMPLQLLQCI-----VDEDSPVLPVG 376
Query: 244 DISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWL 276
+ S FI C+++ P +RP ++L+ H ++
Sbjct: 377 EFSEPFVHFITQCMRKQPKERPAPEELMGHPFI 409
>CE03979 [T] KOG0614 cGMP-dependent protein kinase
Length = 581
Score = 104 bits (259), Expect = 3e-22
Identities = 72/226 (31%), Positives = 101/226 (43%), Gaps = 20/226 (8%)
Query: 2 LSLQQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEH--SNEPID 59
+ L+ Q + +G G FG V L S A+K +N H +
Sbjct: 269 VELEDLQRVSTLGMGGFGRVELVRSASSRT------------YALKIMNKAHIVETKQES 316
Query: 60 LLLKEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFI 119
++ E L YI Y T+ +Y++ME C T F
Sbjct: 317 HVVSERRILMQCDNDYIVRMYKTYRDSEKIYMLMEPCLGGEIWTILRKKGRFDNDLTRFY 376
Query: 120 ILQVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTF 179
ALEYLH K +++RDLK N+LL+ +G +L D G +LK +GG+ TF
Sbjct: 377 CAGAMEALEYLHRKNIVYRDLKPENMLLDRNGWPKLVDFGFAKKLK-----NGGRTW-TF 430
Query: 180 VGTPFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSM 225
GT ++APEI+ N+ +D DIW+LGI ELL G PP S D M
Sbjct: 431 CGTAEYVAPEIVLNKGHDLSVDIWALGIFMCELLTGSPPFSSTDPM 476
>7299438 [R] KOG0586 Serine/threonine protein kinase
Length = 705
Score = 104 bits (259), Expect = 3e-22
Identities = 77/277 (27%), Positives = 129/277 (45%), Gaps = 32/277 (11%)
Query: 7 FQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPI-DLLLKEI 65
+++++ +GKGNF V LA ++ + +E +AIK I+ N L +E+
Sbjct: 98 YKIIKTLGKGNFAKVKLAIHVPTGRE-----------VAIKVIDKTQLNTSARQKLYREV 146
Query: 66 YFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVCH 125
+ L+ P I + + LY+VMEY S E+ I Q+
Sbjct: 147 KIMKLLNHPNIVRLFQVIESERTLYLVMEYASRGELFDHLVKNGRMRERDARVIFRQLVS 206
Query: 126 ALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFW 185
A++Y H K ++HRDLKA N+LL+ +++AD G F +T L TF G+P +
Sbjct: 207 AIQYCHSKFVVHRDLKAENLLLDQHMNIKIADFG------FGNTFDPNAQLETFCGSPPY 260
Query: 186 MAPEIIKNQSYDG-KCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRN-- 242
APE+ + Y G + D WSLG+ L++G P ++K L + +LR
Sbjct: 261 AAPELFMGRKYAGPEVDAWSLGVVLYTLVSGSLPFDG-GTLKEL-------RERVLRGKY 312
Query: 243 ---MDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWL 276
IS ++ +R L +P +R + ++ KW+
Sbjct: 313 RVPYYISMDCENLMRKFLVLNPAKRTSLSAVMSDKWI 349
>YPL203w [T] KOG0616 cAMP-dependent protein kinase catalytic subunit (PKA)
Length = 380
Score = 103 bits (258), Expect = 4e-22
Identities = 65/229 (28%), Positives = 108/229 (46%), Gaps = 17/229 (7%)
Query: 3 SLQQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLL 62
+L FQ++ +G G+FG V+L + + + + K + +K +EH+N+
Sbjct: 66 TLHDFQIMRTLGTGSFGRVHLVRSVHNGRYYAIKVLKKQQVVKMK--QVEHTND------ 117
Query: 63 KEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQ 122
E L + P++ +GTF N+++VM+Y F +
Sbjct: 118 -ERRMLKLVEHPFLIRMWGTFQDARNIFMVMDYIEGGELFSLLRKSQRFPNPVAKFYAAE 176
Query: 123 VCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGT 182
V ALEYLH +I+RDLK NILL+ +G +++ D G +++ + T GT
Sbjct: 177 VILALEYLHAHNIIYRDLKPENILLDRNGHIKITDFGFAKEVQTVTW--------TLCGT 228
Query: 183 PFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRI 231
P ++APE+I + Y+ D WSLG+ E+L G P MK +I
Sbjct: 229 PDYIAPEVITTKPYNKSVDWWSLGVLIYEMLAGYTPFYDTTPMKTYEKI 277
>Hs5174547 [T] KOG4279 Serine/threonine protein kinase
Length = 1374
Score = 103 bits (258), Expect = 4e-22
Identities = 89/277 (32%), Positives = 126/277 (45%), Gaps = 29/277 (10%)
Query: 13 VGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEIYFLSTLH 72
+GKG +G VY L SNQ V +AIK I E + L +EI L
Sbjct: 686 LGKGTYGIVYAGRDL-SNQ----------VRIAIKEIP-ERDSRYSQPLHEEIALHKHLK 733
Query: 73 CPYITHYYGTFTGDCNLYIVMEYC---SXXXXXXXXXXXXXXTEQTTCFIILQVCHALEY 129
I Y G+F+ + + I ME S EQT F Q+ L+Y
Sbjct: 734 HKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKY 793
Query: 130 LHEKRLIHRDLKAANILLND-DGEVRLADLGVTGQLKFNSTRHGGKN--LNTFVGTPFWM 186
LH+ +++HRD+K N+L+N G ++++D G S R G N TF GT +M
Sbjct: 794 LHDNQIVHRDIKGDNVLINTYSGVLKISDFG-------TSKRLAGINPCTETFTGTLQYM 846
Query: 187 APEIIKN--QSYDGKCDIWSLGITTLELLNGKPPMSHL-DSMKALMRIPKLNADSILRNM 243
APEII + Y DIWSLG T +E+ GKPP L + A+ ++ +
Sbjct: 847 APEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPE- 905
Query: 244 DISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKKCS 280
+S K FI C + DP++R LL ++LK S
Sbjct: 906 SMSAEAKAFILKCFEPDPDKRACANDLLVDEFLKVSS 942
>Hs4506071 [T] KOG0695 Serine/threonine protein kinase
Length = 587
Score = 103 bits (258), Expect = 4e-22
Identities = 72/277 (25%), Positives = 122/277 (43%), Gaps = 29/277 (10%)
Query: 2 LSLQQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLL 61
L LQ F LL +G+G++ V L K + + + L + +E ID +
Sbjct: 240 LGLQDFDLLRVIGRGSYAKVLLVRL---------KKTDRIYAMKVVKKELVNDDEDIDWV 290
Query: 62 LKEIY-FLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFII 120
E + F + P++ + F + L+ V+EY + E+ F
Sbjct: 291 QTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYS 350
Query: 121 LQVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFV 180
++ AL YLHE+ +I+RDLK N+LL+ +G ++L D G+ G +TF
Sbjct: 351 AEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMC-----KEGLRPGDTTSTFC 405
Query: 181 GTPFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSIL 240
GTP ++APEI++ + Y D W+LG+ E++ G+ P + S P N + L
Sbjct: 406 GTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDN----PDQNTEDYL 461
Query: 241 RNM----------DISPLGKDFIRSCLQQDPNQRPTC 267
+ +S ++S L +DP +R C
Sbjct: 462 FQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGC 498
>Hs20545245 [D] KOG0588 Serine/threonine protein kinase
Length = 795
Score = 103 bits (258), Expect = 4e-22
Identities = 72/271 (26%), Positives = 128/271 (46%), Gaps = 22/271 (8%)
Query: 7 FQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLL-KEI 65
++L + +GKG G V L + + Q+ +AIK +N E +E + + + +EI
Sbjct: 51 YRLEKTLGKGQTGLVKLGVHCITGQK-----------VAIKIVNREKLSESVLMKVEREI 99
Query: 66 YFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVCH 125
L + P++ + + LY+V+E+ S T + Q+
Sbjct: 100 AILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVS 159
Query: 126 ALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFW 185
AL++ H + HRDLK N+LL++ +R+AD G+ S + G L T G+P +
Sbjct: 160 ALDFCHSYSICHRDLKPENLLLDEKNNIRIADFGMA------SLQVGDSLLETSCGSPHY 213
Query: 186 MAPEIIKNQSYDG-KCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRNMD 244
PE+IK + YDG + D+WS G+ LL G P D+++ L+ K+
Sbjct: 214 ACPEVIKGEKYDGRRADMWSCGVILFALLVGALPFDD-DNLRQLLE--KVKRGVFHMPHF 270
Query: 245 ISPLGKDFIRSCLQQDPNQRPTCKQLLQHKW 275
I P + +R ++ +P +R + +Q+ +H W
Sbjct: 271 IPPDCQSLLRGMIEVEPEKRLSLEQIQKHPW 301
>7301213 [R] KOG0589 Serine/threonine protein kinase
Length = 841
Score = 103 bits (258), Expect = 4e-22
Identities = 79/282 (28%), Positives = 125/282 (44%), Gaps = 34/282 (12%)
Query: 4 LQQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEP-IDLLL 62
L ++ + VG+G+FG L + + K INL + P DL +
Sbjct: 102 LANYEKVRVVGQGSFGIAILYRRKSDGHQ-----------IVFKQINLSELSPPGRDLAM 150
Query: 63 KEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIIL- 121
E+ S LH P I Y G+F D L I MEY +II
Sbjct: 151 NEVDVFSKLHHPNIVSYLGSFIKDNTLLIEMEYADGGTLAQIIAERQGKLHFPERYIIAV 210
Query: 122 --QVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTF 179
Q+ A+ Y+H + ++HRDLK AN+ LN G V++ D G++ K +T+ + T
Sbjct: 211 FEQISSAINYMHSENILHRDLKTANVFLNRRGIVKIGDFGIS---KIMNTK---IHAQTV 264
Query: 180 VGTPFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSI 239
+GTP++ +PE+ + + YD K DIW+LG E M L A + +L +
Sbjct: 265 LGTPYYFSPEMCEGKEYDNKSDIWALGCILGE-------MCCLKKTFAASNLSELVTKIM 317
Query: 240 LRNMDISPLG-----KDFIRSCLQQDPNQRPTCKQLLQHKWL 276
N P G + + + LQ + +RPT ++L + W+
Sbjct: 318 AGNYTPVPSGYTSGLRSLMSNLLQVEAPRRPTASEVLVY-WI 358
>YDR507c [D] KOG0588 Serine/threonine protein kinase
Length = 1142
Score = 103 bits (257), Expect = 6e-22
Identities = 101/402 (25%), Positives = 165/402 (40%), Gaps = 38/402 (9%)
Query: 7 FQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLA--IKCINLEHSNEPIDL---L 61
++L E +G G+ G V LA + QE I K V + ++ S P L +
Sbjct: 19 WKLGETLGLGSTGKVQLARNGSTGQEAAVKVISKAVFNTGNVSGTSIVGSTTPDALPYGI 78
Query: 62 LKEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIIL 121
+EI + L+ P + Y + + +LY+V+EY E
Sbjct: 79 EREIIIMKLLNHPNVLRLYDVWETNTDLYLVLEYAEKGELFNLLVERGPLPEHEAIRFFR 138
Query: 122 QVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVG 181
Q+ + Y H ++HRDLK N+LL+ +++AD G+ + GK L T G
Sbjct: 139 QIIIGVSYCHALGIVHRDLKPENLLLDHKYNIKIADFGMA------ALETEGKLLETSCG 192
Query: 182 TPFWMAPEIIKNQSYDG-KCDIWSLGITTLELLNGKPPMSHLD-SMKALMRIPKLNADSI 239
+P + APEI+ Y G D+WS G+ LL G+ P D +++ L+ + +
Sbjct: 193 SPHYAAPEIVSGIPYQGFASDVWSCGVILFALLTGRLPFDEEDGNIRTLLLKVQKGEFEM 252
Query: 240 LRNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKKCSITNIMEEITVMKTNQILSK 299
+ +IS +D IR L DP +R + +L+H L+K + I +
Sbjct: 253 PSDDEISREAQDLIRKILTVDPERRIKTRDILKHPLLQKYPSIRDSKSI----------R 302
Query: 300 EKPRSCKPRFPLSD---KVYKTNLPNQLESWRFED----ESVLRFDGLGDIPNLYXXXXX 352
PR PLS+ + T L N + W D + LR G LY
Sbjct: 303 GLPREDTYLTPLSESNSSIDATILQNLVILWHGRDPEGIKEKLREPGANAEKTLYALLYR 362
Query: 353 XXXXXXSPLLTKQQLRTPNISTPTSALSPTSMAISPKTNLST 394
L+ +QQ++ S +S+++SP +ST
Sbjct: 363 FKCDTQKELIKQQQVK--------KRQSISSVSVSPSKKVST 396
>Hs14770402 [R] KOG0586 Serine/threonine protein kinase
Length = 926
Score = 103 bits (257), Expect = 6e-22
Identities = 74/272 (27%), Positives = 122/272 (44%), Gaps = 34/272 (12%)
Query: 13 VGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSNEPIDLLLKEIYFLSTLH 72
+GKGNF V L + + E I K+ + +NLE + +E+ + L
Sbjct: 26 LGKGNFAVVKLGRHRITKTEVAIKIIDKS---QLDAVNLEK-------IYREVQIMKMLD 75
Query: 73 CPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFIILQVCHALEYLHE 132
P+I Y LY+V EY E Q+ A++Y H
Sbjct: 76 HPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHG 135
Query: 133 KRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTFVGTPFWMAPEIIK 192
++++HRDLKA N+LL+++ +++AD G F + G+ L T+ G+P + APE+ +
Sbjct: 136 RKIVHRDLKAENLLLDNNMNIKIADFG------FGNFFKSGELLATWCGSPPYAAPEVFE 189
Query: 193 NQSYDG-KCDIWSLGITTLELLNGKPPMS-------HLDSMKALMRIPKLNADSILRNMD 244
Q Y+G + DIWS+G+ L+ G P ++ RIP ++
Sbjct: 190 GQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDC----- 244
Query: 245 ISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWL 276
+ IR L DP++R T Q+ +HKW+
Sbjct: 245 -----EHLIRRMLVLDPSKRLTIAQIKEHKWM 271
>CE19898 [T] KOG0614 cGMP-dependent protein kinase
Length = 737
Score = 103 bits (257), Expect = 6e-22
Identities = 76/282 (26%), Positives = 121/282 (41%), Gaps = 25/282 (8%)
Query: 2 LSLQQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEH--SNEPID 59
++L+ + L +G G FG V L G K A+K + +H +
Sbjct: 421 VTLKNVKRLATLGVGGFGRVELVCVNGD----------KAKTFALKALKKKHIVDTRQQE 470
Query: 60 LLLKEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFI 119
+ E + +I Y TF +Y+++E C + T F
Sbjct: 471 HIFAERNIMMETSTDWIVKLYKTFRDQKFVYMLLEVCLGGELWTTLRDRGHFDDYTARFY 530
Query: 120 ILQVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTF 179
+ V LEYLH K +++RDLK N LL + G ++L D G +L G+ TF
Sbjct: 531 VACVLEGLEYLHRKNIVYRDLKPENCLLANTGYLKLVDFGFAKKLA------SGRKTWTF 584
Query: 180 VGTPFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSI 239
GTP +++PEII N+ +D D W+LGI EL+ G+PP D MK I K D++
Sbjct: 585 CGTPEYVSPEIILNKGHDQAADYWALGIYICELMLGRPPFQASDPMKTYTLILK-GVDAL 643
Query: 240 -LRNMDISPLGKDFIRSCLQQDPNQR-----PTCKQLLQHKW 275
+ N I ++ + +P +R + +H+W
Sbjct: 644 EIPNRRIGKTATALVKKLCRDNPGERLGSGSGGVNDIRKHRW 685
>CE19897 [T] KOG0614 cGMP-dependent protein kinase
Length = 780
Score = 103 bits (257), Expect = 6e-22
Identities = 76/282 (26%), Positives = 121/282 (41%), Gaps = 25/282 (8%)
Query: 2 LSLQQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEH--SNEPID 59
++L+ + L +G G FG V L G K A+K + +H +
Sbjct: 464 VTLKNVKRLATLGVGGFGRVELVCVNGD----------KAKTFALKALKKKHIVDTRQQE 513
Query: 60 LLLKEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFI 119
+ E + +I Y TF +Y+++E C + T F
Sbjct: 514 HIFAERNIMMETSTDWIVKLYKTFRDQKFVYMLLEVCLGGELWTTLRDRGHFDDYTARFY 573
Query: 120 ILQVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTF 179
+ V LEYLH K +++RDLK N LL + G ++L D G +L G+ TF
Sbjct: 574 VACVLEGLEYLHRKNIVYRDLKPENCLLANTGYLKLVDFGFAKKLA------SGRKTWTF 627
Query: 180 VGTPFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSI 239
GTP +++PEII N+ +D D W+LGI EL+ G+PP D MK I K D++
Sbjct: 628 CGTPEYVSPEIILNKGHDQAADYWALGIYICELMLGRPPFQASDPMKTYTLILK-GVDAL 686
Query: 240 -LRNMDISPLGKDFIRSCLQQDPNQR-----PTCKQLLQHKW 275
+ N I ++ + +P +R + +H+W
Sbjct: 687 EIPNRRIGKTATALVKKLCRDNPGERLGSGSGGVNDIRKHRW 728
>At4g35780 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 553
Score = 103 bits (257), Expect = 6e-22
Identities = 72/273 (26%), Positives = 128/273 (46%), Gaps = 22/273 (8%)
Query: 2 LSLQQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEHSN-EPIDL 60
+ ++Q ++ + V G++G+++ Y +AIK + E N E +
Sbjct: 270 IDMKQLKIEKKVACGSYGELFRGTYCSQE-------------VAIKILKPERVNAEMLRE 316
Query: 61 LLKEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTE-QTTCFI 119
+E+Y + + + + G T NL IV E+ + + Q+ +
Sbjct: 317 FSQEVYIMRKVRHKNVVQFIGACTRSPNLCIVTEFMTRGSIYDFLHKHKGVFKIQSLLKV 376
Query: 120 ILQVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTF 179
L V + YLH+ +IHRDLK AN+L+++ V++AD GV T G T
Sbjct: 377 ALDVSKGMNYLHQNNIIHRDLKTANLLMDEHEVVKVADFGVARV----QTESGVMTAET- 431
Query: 180 VGTPFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSI 239
GT WMAPE+I+++ YD + D++S I ELL G+ P S+L ++A + + +
Sbjct: 432 -GTYRWMAPEVIEHKPYDHRADVFSYAIVLWELLTGELPYSYLTPLQAAVGVVQKGLRPK 490
Query: 240 LRNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQ 272
+ + P + + C QQDP RP ++++
Sbjct: 491 IPK-ETHPKLTELLEKCWQQDPALRPNFAEIIE 522
>At3g06620 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 773
Score = 103 bits (257), Expect = 6e-22
Identities = 83/297 (27%), Positives = 141/297 (46%), Gaps = 34/297 (11%)
Query: 11 ECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINL-EHSNEPIDLLLKEIYFLS 69
E VG+G+ G VY + GS+ +A+K + E+S E I+ +E+ +
Sbjct: 498 EQVGQGSCGTVYHGLWFGSD-------------VAVKVFSKQEYSAEVIESFKQEVLLMK 544
Query: 70 TLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTE-QTTCFIILQVCHALE 128
L P + + G T L IV E+ + + + L + +
Sbjct: 545 RLRHPNVLLFMGAVTSPQRLCIVSEFLPRGSLFRLLQKSTSKLDWRRRIHMALDIARGMN 604
Query: 129 YLHE--KRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNS--TRHGGKNLNTFVGTPF 184
YLH +IHRDLK++N+L++ + V++AD G++ ++K + T GK GTP
Sbjct: 605 YLHHCSPPIIHRDLKSSNLLVDKNWTVKVADFGLS-RIKHETYLTSKSGK------GTPQ 657
Query: 185 WMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSILRNMD 244
WMAPE+++N+S D K DI+S G+ EL K P L+SM+ + + ++ + D
Sbjct: 658 WMAPEVLRNESADEKSDIYSFGVVLWELATEKIPWETLNSMQVIGAVGFMD-QRLEIPKD 716
Query: 245 ISPLGKDFIRSCLQQDPNQRPTCKQL------LQHKWLKKCSITN-IMEEITVMKTN 294
I P + SC D RPT ++L LQ K++ + T + + +++K N
Sbjct: 717 IDPRWISLMESCWHSDTKLRPTFQELMDKLRDLQRKYMIQFQATRAALSDNSLLKDN 773
>At2g17700 [T] KOG0192 Tyrosine kinase specific for activated (GTP-bound)
p21cdc42Hs
Length = 546
Score = 103 bits (257), Expect = 6e-22
Identities = 76/292 (26%), Positives = 137/292 (46%), Gaps = 29/292 (9%)
Query: 2 LSLQQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLEH-SNEPIDL 60
+ + Q ++ + V G++GD++ Y +AIK + + +NE +
Sbjct: 281 IDVTQLKIEKKVASGSYGDLHRGTYCSQE-------------VAIKFLKPDRVNNEMLRE 327
Query: 61 LLKEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTE-QTTCFI 119
+E++ + + + + G T L IV E+ + + QT +
Sbjct: 328 FSQEVFIMRKVRHKNVVQFLGACTRSPTLCIVTEFMARGSIYDFLHKQKCAFKLQTLLKV 387
Query: 120 ILQVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTF 179
L V + YLH+ +IHRDLK AN+L+++ G V++AD GV +++ S G T
Sbjct: 388 ALDVAKGMSYLHQNNIIHRDLKTANLLMDEHGLVKVADFGV-ARVQIES---GVMTAET- 442
Query: 180 VGTPFWMAPEIIKNQSYDGKCDIWSLGITTLELLNGKPPMSHLDSMKALMRIPKLNADSI 239
GT WMAPE+I+++ Y+ K D++S I ELL G P + L ++A + + +
Sbjct: 443 -GTYRWMAPEVIEHKPYNHKADVFSYAIVLWELLTGDIPYAFLTPLQAAVGVVQKGLRPK 501
Query: 240 LRNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKKCSITNIMEEITVM 291
+ P K + C QDP QRP +++++ + IM+E+ V+
Sbjct: 502 IPK-KTHPKVKGLLERCWHQDPEQRPLFEEIIE-------MLQQIMKEVNVV 545
>Hs5453966 [T] KOG0583 Serine/threonine protein kinase
Length = 552
Score = 103 bits (256), Expect = 7e-22
Identities = 116/501 (23%), Positives = 201/501 (39%), Gaps = 58/501 (11%)
Query: 2 LSLQQFQLLECVGKGNFGDVYLAHYLGSNQEPTDPKIPKNVPLAIKCINLE--HSNEPID 59
+ + + L + +G G FG V + + + T K+ A+K +N + S + +
Sbjct: 11 VKIGHYVLGDTLGVGTFGKVKIGEH-----QLTGHKV------AVKILNRQKIRSLDVVG 59
Query: 60 LLLKEIYFLSTLHCPYITHYYGTFTGDCNLYIVMEYCSXXXXXXXXXXXXXXTEQTTCFI 119
+ +EI L P+I Y + + ++VMEY S E +
Sbjct: 60 KIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRL 119
Query: 120 ILQVCHALEYLHEKRLIHRDLKAANILLNDDGEVRLADLGVTGQLKFNSTRHGGKNLNTF 179
Q+ A++Y H ++HRDLK N+LL+ ++AD G++ + G+ L T
Sbjct: 120 FQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMS------DGEFLRTS 173
Query: 180 VGTPFWMAPEIIKNQSYDG-KCDIWSLGITTLELLNGKPPM--SHLDSMKALMRIPKLNA 236
G+P + APE+I + Y G + DIWS G+ LL G P H+ ++ +R
Sbjct: 174 CGSPNYTAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYI 233
Query: 237 DSILRNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKWLKKCSITNIMEEITVMKTNQI 296
L N ++ L + LQ DP +R T K + +H+W K+ + + E N +
Sbjct: 234 PEYL-NRSVATL----LMHMLQVDPLKRATIKDIREHEWFKQGLPSYLFPEDPSYDAN-V 287
Query: 297 LSKEKPRSCKPRFPLSDKVYKTNLPNQLESWRFEDESVLRFDGLGDIPNLYXXXXXXXXX 356
+ E + +F ++ + + N L S +D+ + + + D +
Sbjct: 288 IDDEAVKEVCEKFECTE----SEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLA 343
Query: 357 XXSP---LLTKQQLRTPNISTPTSALSPTSMAISPKTNLSTPATESYEDVSSSPSEQKMK 413
P + + P P P +A SPK A + + S + + K +
Sbjct: 344 SSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWR 403
Query: 414 LGHENQNIDY----------------WKDVFLYSLKKVRQRAINEPTKETVK-SLTRYMG 456
G +Q+ Y WK V Y L R R N T VK SL Y+
Sbjct: 404 QGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHL---RVRRKNPVTGNYVKMSLQLYLV 460
Query: 457 DLEK---DFPGLSEALVQEIS 474
D DF + + +V++ S
Sbjct: 461 DNRSYLLDFKSIDDEVVEQRS 481
>Hs21735542 [T] KOG0983 Mitogen-activated protein kinase (MAPK) kinase
MKK7/JNKK2
Length = 462
Score = 103 bits (256), Expect = 7e-22
Identities = 68/243 (27%), Positives = 120/243 (48%), Gaps = 14/243 (5%)
Query: 44 LAIKCINLEHSNEPIDLLLKEIYFLSTLH-CPYITHYYGTFTGDCNLYIVMEYCSXXXXX 102
+A+K + + E +L ++ + H CPYI +GTF + +++I ME
Sbjct: 189 IAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEK 248
Query: 103 XXXXXXXXXTEQTTCFIILQVCHALEYLHEKR-LIHRDLKAANILLNDDGEVRLADLGVT 161
E+ + + + AL YL EK +IHRD+K +NILL++ G+++ D G++
Sbjct: 249 LKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKFCDFGIS 308
Query: 162 GQLKFNSTRHGGKNLNTFVGTPFWMAPEII-----KNQSYDGKCDIWSLGITTLELLNGK 216
G+L K G +MAPE I YD + D+WSLGI+ +EL G+
Sbjct: 309 GRLV------DSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQ 362
Query: 217 PPMSHLDS-MKALMRIPKLNADSILRNMDISPLGKDFIRSCLQQDPNQRPTCKQLLQHKW 275
P + + + L ++ + + +M S + F++ CL +D +RP +LL+H +
Sbjct: 363 FPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSF 422
Query: 276 LKK 278
+K+
Sbjct: 423 IKR 425
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.318 0.135 0.403
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,862,825
Number of Sequences: 60738
Number of extensions: 1317519
Number of successful extensions: 9933
Number of sequences better than 1.0e-05: 1700
Number of HSP's better than 0.0 without gapping: 296
Number of HSP's successfully gapped in prelim test: 1404
Number of HSP's that attempted gapping in prelim test: 5915
Number of HSP's gapped (non-prelim): 2157
length of query: 483
length of database: 30,389,216
effective HSP length: 110
effective length of query: 373
effective length of database: 23,708,036
effective search space: 8843097428
effective search space used: 8843097428
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)