ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIII0270 good G KOG1369 Carbohydrate transport and metabolism Hexokinase
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIII0270 88084 89526 481
(481 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YCL040w [G] KOG1369 Hexokinase 552 e-157
YDR516c [G] KOG1369 Hexokinase 524 e-148
SPAC24H6.04 [G] KOG1369 Hexokinase 261 1e-69
YFR053c [G] KOG1369 Hexokinase 246 7e-65
YGL253w [G] KOG1369 Hexokinase 231 2e-60
SPAC4F8.07c [G] KOG1369 Hexokinase 226 6e-59
CE05628 [G] KOG1369 Hexokinase 214 2e-55
Hs15991833 [G] KOG1369 Hexokinase 214 3e-55
Hs15991829 [G] KOG1369 Hexokinase 214 3e-55
Hs15991827 [G] KOG1369 Hexokinase 214 3e-55
Hs4504391 [G] KOG1369 Hexokinase 213 5e-55
Hs15553127 [G] KOG1369 Hexokinase 211 1e-54
At2g19860 [G] KOG1369 Hexokinase 209 7e-54
At1g47840 [G] KOG1369 Hexokinase 208 2e-53
7291070 [G] KOG1369 Hexokinase 207 3e-53
At4g29130 [G] KOG1369 Hexokinase 207 4e-53
At1g50460 [G] KOG1369 Hexokinase 201 3e-51
7303093 [G] KOG1369 Hexokinase 200 4e-51
Hs4504395 [G] KOG1369 Hexokinase 196 5e-50
At3g20040 [G] KOG1369 Hexokinase 195 1e-49
CE18823 [G] KOG1369 Hexokinase 184 3e-46
7301467 [G] KOG1369 Hexokinase 184 3e-46
Hs15967161 [G] KOG1369 Hexokinase 182 7e-46
Hs4503951 [G] KOG1369 Hexokinase 181 2e-45
Hs15967159 [G] KOG1369 Hexokinase 181 2e-45
CE25610 [G] KOG1369 Hexokinase 128 2e-29
Hs13376711 [G] KOG1369 Hexokinase 121 3e-27
At4g37840 [G] KOG1369 Hexokinase 116 7e-26
At1g47860_3 [G] KOG1369 Hexokinase 67 5e-11
ECU11g1540 [G] KOG1369 Hexokinase 54 4e-07
>YCL040w [G] KOG1369 Hexokinase
Length = 500
Score = 552 bits (1423), Expect = e-157
Identities = 294/488 (60%), Positives = 357/488 (72%), Gaps = 19/488 (3%)
Query: 8 KAVDSICDQFIVTKSKISQLTEYFIDCMEKGLEPCESD--ISQNKGLPMIPTFVTDKPSG 65
+AVD ICD F VT K+ +LT YFI+ MEKGL P + ++ +KGLPMIP FVT P+G
Sbjct: 16 QAVDQICDDFEVTPEKLDELTAYFIEQMEKGLAPPKEGHTLASDKGLPMIPAFVTGSPNG 75
Query: 66 QEHGVTMLAADLGGTNFRVCSVELLGNHEFKIEQEKSKIPTFFFQDDHHVTSKDLFQHMA 125
E GV +LAADLGGTNFR+CSV L G+H F +EQ KSKIP DD +VTS DLF +A
Sbjct: 76 TERGV-LLAADLGGTNFRICSVNLHGDHTFSMEQMKSKIPDDLL-DDENVTSDDLFGFLA 133
Query: 126 LITHQFLTKHHKDVIQDYK----WKMGFTFSYPVDQTSLSSGKLIRWTKGFKIGDTVGQD 181
T F+ K+H D + K K+GFTFSYPVDQTSL+SG LIRWTKGF+I DTVG+D
Sbjct: 134 RRTLAFMKKYHPDELAKGKDAKPMKLGFTFSYPVDQTSLNSGTLIRWTKGFRIADTVGKD 193
Query: 182 VVQLFQQELNDIGLSNVHVVALTNDTTGTLLARCYASSDA----ARAINEPVIGCIFGTG 237
VVQL+Q++L+ G+ + VVALTNDT GT L+ CY S + + I+EPVIGCIFGTG
Sbjct: 194 VVQLYQEQLSAQGMPMIKVVALTNDTVGTYLSHCYTSDNTDSMTSGEISEPVIGCIFGTG 253
Query: 238 TNGCYMEKLENIHKLDPASREELLSQGKTHMCINTEWGSFDNELNHLPTTSYDIKIDQQF 297
TNGCYME++ I KL R++L+ +GKTHM IN EWGSFDNEL HLPTT YD+ IDQ+
Sbjct: 254 TNGCYMEEINKITKLPQELRDKLIKEGKTHMIINVEWGSFDNELKHLPTTKYDVVIDQKL 313
Query: 298 STNPGFHLFEKRVSGLYLGEILRNILLDLEKQEL----FDLKESVLKN--NPFILTTETL 351
STNPGFHLFEKRVSG++LGE+LRNIL+DL Q L + KE + ++ PF L++E L
Sbjct: 314 STNPGFHLFEKRVSGMFLGEVLRNILVDLHSQGLLLQQYRSKEQLPRHLTTPFQLSSEVL 373
Query: 352 SHIEIDTVENDLQDTRDALLKAADLETTFEERVLIQKLVRAISRRXXXXXXXXXXXXXXK 411
SHIEID L++T +LL++ L TT ERV IQKLVRAISRR K
Sbjct: 374 SHIEIDD-STGLRETELSLLQSLRLPTTPTERVQIQKLVRAISRRSAYLAAVPLAAILIK 432
Query: 412 TNALNQSYHCQVEVGCDGSVVEHYPGFRSMMRHALALSPIGPEGERDVHLRISKDGSGVG 471
TNALN+ YH +VE+GCDGSVVE+YPGFRSM+RHALALSP+G EGER VHL+I+KDGSGVG
Sbjct: 433 TNALNKRYHGEVEIGCDGSVVEYYPGFRSMLRHALALSPLGAEGERKVHLKIAKDGSGVG 492
Query: 472 AALCALHA 479
AALCAL A
Sbjct: 493 AALCALVA 500
>YDR516c [G] KOG1369 Hexokinase
Length = 500
Score = 524 bits (1349), Expect = e-148
Identities = 284/491 (57%), Positives = 347/491 (69%), Gaps = 21/491 (4%)
Query: 6 LTKAVDSICDQFIVTKSKISQLTEYFIDCMEKGLEPCE--SDISQNKGLPMIPTFVTDKP 63
L AV IC V +K+ +LT YFI+CMEKGL + + +KGLPMIPT+VT P
Sbjct: 14 LEDAVVEICSSLQVDAAKLDELTAYFIECMEKGLNNTSVGEEKTVDKGLPMIPTYVTSLP 73
Query: 64 SGQEHGVTMLAADLGGTNFRVCSVELLGNHEFKIEQEKSKIPTFFFQDDHHVTSKDLFQH 123
+G E GV +LAADLGGT+FRVCSV L G+ F ++Q KSKIP + +D VTS++LF +
Sbjct: 74 NGTERGV-LLAADLGGTHFRVCSVTLNGDGTFDMQQLKSKIPEEYL-NDKDVTSEELFSY 131
Query: 124 MALITHQFLTKHHKDVIQDY-----KWKMGFTFSYPVDQTSLSSGKLIRWTKGFKIGDTV 178
+ T F+ KHH ++++ KMGFTFSYPVDQTSLSSG LIRWTK FKI DTV
Sbjct: 132 LGRRTRAFVRKHHPELLKSTGENIKPLKMGFTFSYPVDQTSLSSGTLIRWTKSFKIEDTV 191
Query: 179 GQDVVQLFQQELNDIGLSNVHVVALTNDTTGTLLARCYASSD---AARAINEPVIGCIFG 235
G+DVV+L+Q++L+ GLS ++VVALTNDT GT L+ CY S +A I+EPVIGCIFG
Sbjct: 192 GKDVVRLYQEQLDIQGLSMINVVALTNDTVGTFLSHCYTSGSRPSSAGEISEPVIGCIFG 251
Query: 236 TGTNGCYMEKLENIHKLDPASREELLSQGKTHMCINTEWGSFDNELNHLPTTSYDIKIDQ 295
TGTNGCYME +ENI KL R LL +GKT MCIN EWGSFDNEL HL T YDI IDQ
Sbjct: 252 TGTNGCYMEDIENIKKLPDELRTRLLHEGKTQMCINIEWGSFDNELKHLSATKYDIDIDQ 311
Query: 296 QFSTNPGFHLFEKRVSGLYLGEILRNILLDLEKQEL-------FDLKESVLKNNPFILTT 348
+FS NPG+HLFEKR+SG+YLGE+LRNIL+DL + L +D LK PF L +
Sbjct: 312 KFSPNPGYHLFEKRISGMYLGELLRNILVDLHARGLILGQYRNYDQLPHRLK-TPFQLCS 370
Query: 349 ETLSHIEIDTVENDLQDTRDALLKAADLETTFEERVLIQKLVRAISRRXXXXXXXXXXXX 408
E LS IEID N L++T + L++ L TTFEER IQ LVR+I+RR
Sbjct: 371 EVLSRIEIDDSTN-LRETELSFLQSLRLPTTFEERKAIQNLVRSITRRSAYLAAVPIAAI 429
Query: 409 XXKTNALNQSYHCQVEVGCDGSVVEHYPGFRSMMRHALALSPIGPEGERDVHLRISKDGS 468
KTNALN+ YH +VE+G DG V+E+YPGFRSM+RHALALSPIG EGER +HLR++KDGS
Sbjct: 430 LIKTNALNKRYHGEVEIGFDGYVIEYYPGFRSMLRHALALSPIGTEGERKIHLRLAKDGS 489
Query: 469 GVGAALCALHA 479
GVGAALCAL A
Sbjct: 490 GVGAALCALVA 500
>SPAC24H6.04 [G] KOG1369 Hexokinase
Length = 484
Score = 261 bits (668), Expect = 1e-69
Identities = 179/478 (37%), Positives = 250/478 (51%), Gaps = 39/478 (8%)
Query: 2 SDPKLTKAV----DSICDQFIVTKSKISQLTEYFIDCMEKGLEPCESDISQNKGLPMIPT 57
S+ KL K + D + +QF + + ++T+ F+ + KGL D+ PM+PT
Sbjct: 19 SNIKLNKTLQDHLDELEEQFTIPTELLHRVTDRFVSELYKGLTTNPGDV------PMVPT 72
Query: 58 FVTDKPSGQEHGVTMLAADLGGTNFRVCSVELLGNHEFKIEQEKSKIPTFFFQDDHHVTS 117
++ P G EHG + LA DLGGTN RVC+VE+ GN +F I Q K ++P Q+ T
Sbjct: 73 WIIGTPDGNEHG-SYLALDLGGTNLRVCAVEVQGNGKFDITQSKYRLP----QELKVGTR 127
Query: 118 KDLFQHMALITHQFLTKHHKDVIQDYKWKMGFTFSYPVDQTSLSSGKLIRWTKGFKIGDT 177
+ LF ++A +F+ + H Q+ + +GFTFSYP Q S++ L+ WTKGF I
Sbjct: 128 EALFDYIADCIKKFVEEVHPGKSQNLE--IGFTFSYPCVQRSINDASLVAWTKGFDIDGV 185
Query: 178 VGQDVVQLFQQELNDIGLSNVHVVALTNDTTGTLLARCYASSDAARAINEPVIGCIFGTG 237
G+ V L L +G +NV + A+ +DTTGTL+A YAS IG IFGTG
Sbjct: 186 EGESVGPLLSAALKRVGCNNVRLNAILSDTTGTLVASNYASPGTE-------IGVIFGTG 238
Query: 238 TNGCYMEKLENIHKLDPASREELLSQGKTHMCINTEWGSFDNELNHLPTTSYDIKIDQQF 297
N CY+EK I KL E +M IN EW FDN+ LP T YD+ ID++
Sbjct: 239 CNACYIEKFSEIPKLHKYDFPE-----DMNMIINCEWCDFDNQHVVLPRTKYDVAIDEE- 292
Query: 298 STNPGFHLFEKRVSGLYLGEILRNILLDL-EKQELFDLKESVLKNNPFILTTETLSHIEI 356
S PG +EK ++G YLG+ILR ILLDL E+ LF+ ++ +P + T LS IE+
Sbjct: 293 SPRPGLQTYEKMIAGCYLGDILRRILLDLYEQGALFNGQDVTKIRDPLAMDTSVLSAIEV 352
Query: 357 DTVENDLQDTRDALLKAADLETTFEERVLIQKLVRAISRRXXXXXXXXXXXXXXKTNALN 416
D EN L +T+ + L+TT EER I++ I R K N +
Sbjct: 353 DPFEN-LDETQTLFEETYGLKTTEEERQFIRRACELIGTRSARLSACGVCALVRKMNKPS 411
Query: 417 QSYHCQVEVGCDGSVVEHYPGFRSMMRHALALSPIGPEGERDVHLRISKDGSGVGAAL 474
+ VG DGSV YP F+ + A +G E V ++DGSGVGAAL
Sbjct: 412 ------MIVGTDGSVYNLYPRFKDRLAQAFK-DILGEEIGSKVVTIPAEDGSGVGAAL 462
>YFR053c [G] KOG1369 Hexokinase
Length = 485
Score = 246 bits (627), Expect = 7e-65
Identities = 172/476 (36%), Positives = 242/476 (50%), Gaps = 34/476 (7%)
Query: 5 KLTKAVDSICDQFIVTKSKISQLTEYFIDCMEKGLEPCESDISQNKGLPMIPTFVTDKPS 64
+L + + D F V + ++ ++FID + KGL + +PMIP +V + P+
Sbjct: 22 ELMDEIHQLEDMFTVDSETLRKVVKHFIDELNKGLT------KKGGNIPMIPGWVMEFPT 75
Query: 65 GQEHGVTMLAADLGGTNFRVCSVELLGNHEFKIEQEKSKIPTFFFQDDHHVTSKDLFQHM 124
G+E G LA DLGGTN RV V+L GNH F Q K K+P H ++L+ +
Sbjct: 76 GKESG-NYLAIDLGGTNLRVVLVKLSGNHTFDTTQSKYKLPHDMRTTKHQ---EELWSFI 131
Query: 125 ALITHQFLTKHHKDVIQDYKWKMGFTFSYPVDQTSLSSGKLIRWTKGFKIGDTVGQDVVQ 184
A F+ + +D +GFTFSYP Q ++ G L RWTKGF I + G DVV
Sbjct: 132 ADSLKDFMVEQELLNTKD-TLPLGFTFSYPASQNKINEGILQRWTKGFDIPNVEGHDVVP 190
Query: 185 LFQQELNDIGLSNVHVVALTNDTTGTLLARCYASSDAARAINEPVIGCIFGTGTNGCYME 244
L Q E++ L + +VAL NDT GTL+A Y E +G IFGTG NG + +
Sbjct: 191 LLQNEISKRELP-IEIVALINDTVGTLIASYYTDP-------ETKMGVIFGTGVNGAFYD 242
Query: 245 KLENIHKLDPASREELLSQGKTHMCINTEWGSFDNELNHLPTTSYDIKIDQQFSTNPGFH 304
+ +I KL+ +++ S + M IN E+GSFDNE LP T YD+ +D+Q S PG
Sbjct: 243 VVSDIEKLEGKLADDIPS--NSPMAINCEYGSFDNEHLVLPRTKYDVAVDEQ-SPRPGQQ 299
Query: 305 LFEKRVSGLYLGEILRNILLDLEKQELFDLKESVLK--NNPFILTTETLSHIEIDTVEND 362
FEK SG YLGE+LR +LL+L ++ L LK+ L P+I+ T + IE D EN
Sbjct: 300 AFEKMTSGYYLGELLRLVLLELNEKGLM-LKDQDLSKLKQPYIMDTSYPARIEDDPFEN- 357
Query: 363 LQDTRDALLKAADLETTFEERVLIQKLVRAISRRXXXXXXXXXXXXXXKTNALNQSYHCQ 422
L+DT D K ++TT ER LI++L I R K +
Sbjct: 358 LEDTDDIFQKDFGVKTTLPERKLIRRLCELIGTRAARLAVCGIAAICQKRG------YKT 411
Query: 423 VEVGCDGSVVEHYPGFRSMMRHAL--ALSPIGPEGERDVHLRISKDGSGVGAALCA 476
+ DGSV YPGF+ L G + + + ++DGSG GAA+ A
Sbjct: 412 GHIAADGSVYNKYPGFKEAAAKGLRDIYGWTGDASKDPITIVPAEDGSGAGAAVIA 467
>YGL253w [G] KOG1369 Hexokinase
Length = 486
Score = 231 bits (589), Expect = 2e-60
Identities = 168/478 (35%), Positives = 238/478 (49%), Gaps = 37/478 (7%)
Query: 5 KLTKAVDSICDQFIVTKSKISQLTEYFIDCMEKGLEPCESDISQNKGLPMIPTFVTDKPS 64
+L + +++ F V + +T++FI +EKGL + +PMIP +V D P+
Sbjct: 22 ELMQQIENFEKIFTVPTETLQAVTKHFISELEKGLS------KKGGNIPMIPGWVMDFPT 75
Query: 65 GQEHGVTMLAADLGGTNFRVCSVELLGNHEFKIEQEKSKIPTFFFQDDHHVTSK--DLFQ 122
G+E G LA DLGGTN RV V+L G+ F Q K ++P D T +L++
Sbjct: 76 GKESG-DFLAIDLGGTNLRVVLVKLGGDRTFDTTQSKYRLP-----DAMRTTQNPDELWE 129
Query: 123 HMALITHQFLTKHHKDVIQDYKWKMGFTFSYPVDQTSLSSGKLIRWTKGFKIGDTVGQDV 182
+A F+ + I + +GFTFS+P Q ++ G L RWTKGF I + DV
Sbjct: 130 FIADSLKAFIDEQFPQGISE-PIPLGFTFSFPASQNKINEGILQRWTKGFDIPNIENHDV 188
Query: 183 VQLFQQELNDIGLSNVHVVALTNDTTGTLLARCYASSDAARAINEPVIGCIFGTGTNGCY 242
V + Q+++ + + VVAL NDTTGTL+A Y E +G IFGTG NG Y
Sbjct: 189 VPMLQKQITKRNIP-IEVVALINDTTGTLVASYYTDP-------ETKMGVIFGTGVNGAY 240
Query: 243 MEKLENIHKLDPASREELLSQGKTHMCINTEWGSFDNELNHLPTTSYDIKIDQQFSTNPG 302
+ +I KL +++ M IN E+GSFDNE LP T YDI ID++ S PG
Sbjct: 241 YDVCSDIEKLQGKLSDDI--PPSAPMAINCEYGSFDNEHVVLPRTKYDITIDEE-SPRPG 297
Query: 303 FHLFEKRVSGLYLGEILRNILLDLEKQELFDLKESVLK-NNPFILTTETLSHIEIDTVEN 361
FEK SG YLGEILR L+D+ KQ + + K + PF++ T + IE D EN
Sbjct: 298 QQTFEKMSSGYYLGEILRLALMDMYKQGFIFKNQDLSKFDKPFVMDTSYPARIEEDPFEN 357
Query: 362 DLQDTRDALLKAADLETTFEERVLIQKLVRAISRRXXXXXXXXXXXXXXKTNALNQSYHC 421
L+DT D + TT +ER LI++L I R K +
Sbjct: 358 -LEDTDDLFQNEFGINTTVQERKLIRRLSELIGARAARLSVCGIAAICQKRG------YK 410
Query: 422 QVEVGCDGSVVEHYPGFRSMMRHALALSPIGPEGERD---VHLRISKDGSGVGAALCA 476
+ DGSV YPGF+ +AL + D + + ++DGSG GAA+ A
Sbjct: 411 TGHIAADGSVYNRYPGFKEKAANALKDIYGWTQTSLDDYPIKIVPAEDGSGAGAAVIA 468
>SPAC4F8.07c [G] KOG1369 Hexokinase
Length = 455
Score = 226 bits (576), Expect = 6e-59
Identities = 156/478 (32%), Positives = 240/478 (49%), Gaps = 43/478 (8%)
Query: 8 KAVDSICDQFIVTKSKISQLTEYFIDCMEKGLEPCESDISQNKGLPMIPTFVTDKPSGQE 67
+AV + + F + + + F + +KGL+ + L M P F++ P+G E
Sbjct: 7 QAVKKLVNDFEYPTESLREAVKEFDELRQKGLQ------KNGEVLAMAPAFISTLPTGAE 60
Query: 68 HGVTMLAADLGGTNFRVCSVELLGNHEFKIEQEKSKIPTFFFQDDHHVTSKDLFQHMALI 127
G LA D GGTN RVC ++LLG+ +++++ KS +P +++ + K + M+
Sbjct: 61 TG-DFLALDFGGTNLRVCWIQLLGDGKYEMKHSKSVLPRECVRNE---SVKPIIDFMSDH 116
Query: 128 THQFLTKHHKDVI---QDYKWKMGFTFSYPVDQTSLSSGKLIRWTKGFKIGDTVGQDVVQ 184
F+ +H ++ MGFTFSYP +Q S++ L+RWTKG I + + +D Q
Sbjct: 117 VELFIKEHFPSKFGCPEEEYLPMGFTFSYPANQVSITESYLLRWTKGLNIPEAINKDFAQ 176
Query: 185 LFQQELNDIGLSNVHVVALTNDTTGTLLARCYASSDAARAINEPVIGCIFGTGTNGCYME 244
+ L + + A+ NDT GTL+ R Y S + ++ +G IFGTGTNG Y+E
Sbjct: 177 FLTEGFKARNLP-IRIEAVINDTVGTLVTRAYTSKE-----SDTFMGIIFGTGTNGAYVE 230
Query: 245 KLENIHKLDPASREELLSQGKTHMCINTEWGSFDNELNHLPTTSYDIKIDQQFSTNPGFH 304
++ I KL + HM IN EWG+ D H +T YD+ +D + N G
Sbjct: 231 QMNQIPKLAGKCTGD-------HMLINMEWGATDFSCLH--STRYDLLLDHD-TPNAGRQ 280
Query: 305 LFEKRVSGLYLGEILRNILLDLEKQELFDLKESVLK---NNPFILTTETLSHIEIDTVEN 361
+FEKRV G+YLGE+ R L L K +++ E + + + L T LS + VE
Sbjct: 281 IFEKRVGGMYLGELFRRALFHLIK--VYNFNEGIFPPSITDAWSLETSVLSRM---MVER 335
Query: 362 DLQDTRDALLKAADLETTFEERVLIQKLVRAISRRXXXXXXXXXXXXXXKTNALNQSYHC 421
++ R+ L + EE + + AI RR T +
Sbjct: 336 SAENVRNVLSTFKFRFRSDEEALYLWDAAHAIGRRAARMSAVPIASLYLSTGRAGK---- 391
Query: 422 QVEVGCDGSVVEHYPGFRSMMRHALALSPIGPEGERDVHLRISKDGSGVGAALCALHA 479
+ +VG DGS+VEHYP F M+R AL IG + E+ + + I+KDGSG+GAALCAL A
Sbjct: 392 KSDVGVDGSLVEHYPHFVDMLREALR-ELIG-DNEKLISIGIAKDGSGIGAALCALQA 447
>CE05628 [G] KOG1369 Hexokinase
Length = 500
Score = 214 bits (546), Expect = 2e-55
Identities = 162/481 (33%), Positives = 241/481 (49%), Gaps = 39/481 (8%)
Query: 1 MSDPKLTKAVDSICDQFIVTKSKISQLTEYFIDCMEKGLEPCESDISQNKGLPMIPTFVT 60
+S PK + C + +++ ++ ++ + ME+GL ++ + M+PT+V
Sbjct: 32 LSRPK--DLIQEACQRLVLSDQQLRRIMQSMEKSMEQGLATSTKKVA----VKMLPTYVD 85
Query: 61 DKPSGQEHGVTMLAADLGGTNFRVCSVELLGNHEFKIEQEKSKIPTFFFQDDHHVTSKDL 120
P+G E G LA DLGGTNFRV ++L G E K+ + ++P + T + L
Sbjct: 86 SVPNGTESG-DFLALDLGGTNFRVLHIKLQGK-ETKMTGKIFRVPESIMRG----TGEAL 139
Query: 121 FQHMALITHQFLTKHHKDVIQDYKWKMGFTFSYPVDQTSLSSGKLIRWTKGFKIGDTVGQ 180
F H+A +F+ ++ D+ K +GFTFS+P +Q L+ GKL+ WTKGFK G
Sbjct: 140 FDHIAGCMAKFMGEN--DLKDAQKLPLGFTFSFPCEQEGLTKGKLVTWTKGFKASGVEGV 197
Query: 181 DVVQLFQQELNDIGLSNVHVVALTNDTTGTLLARCYASSDAARAINEPVIGCIFGTGTNG 240
DVV L + + ++ VVAL NDT GTL+A + N IG I GTGTN
Sbjct: 198 DVVTLLHEACHRRKDIDIDVVALLNDTVGTLMACAFQE-------NSCQIGVIVGTGTNA 250
Query: 241 CYMEKLENIHKLDPASREELLSQGKTHMCINTEWGSF--DNELNHLPTTSYDIKIDQQFS 298
CYME+L+ I KL E ++ M INTEWG+F D L+ L T +D +D++ S
Sbjct: 251 CYMERLDRIPKLAGYVDEHGVT--PEEMIINTEWGAFGDDGALDFL-RTEWDEVVDRE-S 306
Query: 299 TNPGFHLFEKRVSGLYLGEILRNILLDLEKQELFDLKESVLKNNPFILTTETLSHIEIDT 358
NPG HL+EK +SG+Y+GE R +L DL KQ L S + P T+ +S I+ D
Sbjct: 307 INPGQHLYEKMISGMYMGECARVVLEDLAKQGLLFGGNSDAISVPHCFPTKFVSEIDSDL 366
Query: 359 VEND---LQDTRDALLKAADLETTFEERVLIQKLVRAISRRXXXXXXXXXXXXXXKTNAL 415
+E+D Q T L T + + + IS R L
Sbjct: 367 LEDDDRTFQKTYQILEDIGVEMITANDCANVAYVCSLISTRAAHLTAAGIAM------LL 420
Query: 416 NQSYHCQVEVGCDGSVVEHYPGFRSMMRHALALSPIGPEGERDVHLRISKDGSGVGAALC 475
N+ V VG DGSV +P + +++ + + G+ + L +S+DGSG GAAL
Sbjct: 421 NRMNKKHVTVGVDGSVYRFHPTYPTLLDAKIGELIV---GDIEYKLMLSEDGSGRGAALV 477
Query: 476 A 476
A
Sbjct: 478 A 478
>Hs15991833 [G] KOG1369 Hexokinase
Length = 905
Score = 214 bits (544), Expect = 3e-55
Identities = 162/474 (34%), Positives = 235/474 (49%), Gaps = 45/474 (9%)
Query: 8 KAVDSICDQFIVTKSKISQLTEYFIDCMEKGLEPCESDISQNKGLPMIPTFVTDKPSGQE 67
+ ++ F +TK + ++ + ME GL N + M+P+FV P G E
Sbjct: 456 RQIEETLAHFHLTKDMLLEVKKRMRAEMELGLR---KQTHNNAVVKMLPSFVRRTPDGTE 512
Query: 68 HGVTMLAADLGGTNFRVCSVELLGNHEFKIEQEKS--KIPTFFFQDDHHVTSKDLFQHMA 125
+G LA DLGGTNFRV V++ + +E IP Q T ++LF H+
Sbjct: 513 NG-DFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQG----TGEELFDHIV 567
Query: 126 LITHQFLTKHHKDVIQDYKWKMGFTFSYPVDQTSLSSGKLIRWTKGFKIGDTVGQDVVQL 185
FL I+ + +GFTFS+P QTSL +G LI WTKGFK D VG DVV L
Sbjct: 568 SCISDFLDYMG---IKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTL 624
Query: 186 FQQELNDIGLSNVHVVALTNDTTGTLLARCYASSDAARAINEPV--IGCIFGTGTNGCYM 243
+ + ++ VVA+ NDT GT++ Y EP +G I GTG+N CYM
Sbjct: 625 LRDAIKRREEFDLDVVAVVNDTVGTMMTCAY---------EEPTCEVGLIVGTGSNACYM 675
Query: 244 EKLENIHKLDPASREELLSQGKTHMCINTEWGSF-DNELNHLPTTSYDIKIDQQFSTNPG 302
E+++N+ E++ + MCIN EWG+F DN T YD +D ++S N G
Sbjct: 676 EEMKNV---------EMVEGDQGQMCINMEWGAFGDNGCLDDIRTHYDRLVD-EYSLNAG 725
Query: 303 FHLFEKRVSGLYLGEILRNILLDLEKQE-LFDLKESVLKNNPFILTTETLSHIEIDTVEN 361
+EK +SG+YLGEI+RNIL+D K+ LF + S I T+ LS IE D +
Sbjct: 726 KQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLA- 784
Query: 362 DLQDTRDALLKAADLETTFEERVLIQKLVRAISRRXXXXXXXXXXXXXXKTNALNQSYHC 421
L R A+L+ L +T ++ +L++ + +SRR K
Sbjct: 785 -LLQVR-AILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRL 842
Query: 422 QVEVGCDGSVVEHYPGFRSMMRHAL-ALSPIGPEGERDVHLRISKDGSGVGAAL 474
V VG DG++ + +P F +M + LSP + +V +S+DGSG GAAL
Sbjct: 843 NVTVGVDGTLYKLHPHFSRIMHQTVKELSP-----KCNVSFLLSEDGSGKGAAL 891
Score = 192 bits (488), Expect = 9e-49
Identities = 145/449 (32%), Positives = 220/449 (48%), Gaps = 49/449 (10%)
Query: 35 MEKGLEPCESDISQNKGLPMIPTFVTDKPSGQEHGVTMLAADLGGTNFRVCSVELLGNHE 94
M+ GL D + + M+PTFV P G E G +A DLGG++FR+ V++ NHE
Sbjct: 35 MKNGLS---RDFNPTATVKMLPTFVRSIPDGSEKG-DFIALDLGGSSFRILRVQV--NHE 88
Query: 95 ----FKIEQEKSKIPTFFFQDDHHVTSKDLFQHMALITHQFLTKHHKDVIQDYKWKMGFT 150
+E E P ++ H + LF H+A F+ K I+D K +GFT
Sbjct: 89 KNQNVHMESEVYDTP----ENIVHGSGSQLFDHVAECLGDFMEKRK---IKDKKLPVGFT 141
Query: 151 FSYPVDQTSLSSGKLIRWTKGFKIGDTVGQDVVQLFQQELNDIGLSNVHVVALTNDTTGT 210
FS+P Q+ + LI WTK FK G DVV+L + + G + ++VA+ NDT GT
Sbjct: 142 FSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGT 201
Query: 211 LLARCYASSDAARAINEPVIGCIFGTGTNGCYMEKLENIHKLDPASREELLSQGKTHMCI 270
++ Y +G I GTGTN CYME+L +I +L+ + MCI
Sbjct: 202 MMTCGYDDQHCE-------VGLIIGTGTNACYMEELRHI---------DLVEGDEGRMCI 245
Query: 271 NTEWGSF--DNELNHLPTTSYDIKIDQQFSTNPGFHLFEKRVSGLYLGEILRNILLDLEK 328
NTEWG+F D L + T +D +ID+ S NPG LFEK VSG+YLGE++R IL+ + K
Sbjct: 246 NTEWGAFGDDGSLEDI-RTEFDREIDRG-SLNPGKQLFEKMVSGMYLGELVRLILVKMAK 303
Query: 329 QELFDLKESVLKNNPFILTTETLSHIEIDTVENDLQDTRDA--LLKAADLETTFEERVLI 386
+ L L E + P +LT + ++ +E + + +A +L +E + ++ V +
Sbjct: 304 EGL--LFEG--RITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSV 359
Query: 387 QKLVRAISRRXXXXXXXXXXXXXXKTNALNQSYHCQVEVGCDGSVVEHYPGFRSMMRHAL 446
Q + +S R + + + VG DGS+ + +P + L
Sbjct: 360 QHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTL 419
Query: 447 -ALSPIGPEGERDVHLRISKDGSGVGAAL 474
L P + DV +S+ GSG GAA+
Sbjct: 420 RRLVP-----DSDVRFLLSESGSGKGAAM 443
>Hs15991829 [G] KOG1369 Hexokinase
Length = 921
Score = 214 bits (544), Expect = 3e-55
Identities = 162/474 (34%), Positives = 235/474 (49%), Gaps = 45/474 (9%)
Query: 8 KAVDSICDQFIVTKSKISQLTEYFIDCMEKGLEPCESDISQNKGLPMIPTFVTDKPSGQE 67
+ ++ F +TK + ++ + ME GL N + M+P+FV P G E
Sbjct: 472 RQIEETLAHFHLTKDMLLEVKKRMRAEMELGLR---KQTHNNAVVKMLPSFVRRTPDGTE 528
Query: 68 HGVTMLAADLGGTNFRVCSVELLGNHEFKIEQEKS--KIPTFFFQDDHHVTSKDLFQHMA 125
+G LA DLGGTNFRV V++ + +E IP Q T ++LF H+
Sbjct: 529 NG-DFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQG----TGEELFDHIV 583
Query: 126 LITHQFLTKHHKDVIQDYKWKMGFTFSYPVDQTSLSSGKLIRWTKGFKIGDTVGQDVVQL 185
FL I+ + +GFTFS+P QTSL +G LI WTKGFK D VG DVV L
Sbjct: 584 SCISDFLDYMG---IKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTL 640
Query: 186 FQQELNDIGLSNVHVVALTNDTTGTLLARCYASSDAARAINEPV--IGCIFGTGTNGCYM 243
+ + ++ VVA+ NDT GT++ Y EP +G I GTG+N CYM
Sbjct: 641 LRDAIKRREEFDLDVVAVVNDTVGTMMTCAY---------EEPTCEVGLIVGTGSNACYM 691
Query: 244 EKLENIHKLDPASREELLSQGKTHMCINTEWGSF-DNELNHLPTTSYDIKIDQQFSTNPG 302
E+++N+ E++ + MCIN EWG+F DN T YD +D ++S N G
Sbjct: 692 EEMKNV---------EMVEGDQGQMCINMEWGAFGDNGCLDDIRTHYDRLVD-EYSLNAG 741
Query: 303 FHLFEKRVSGLYLGEILRNILLDLEKQE-LFDLKESVLKNNPFILTTETLSHIEIDTVEN 361
+EK +SG+YLGEI+RNIL+D K+ LF + S I T+ LS IE D +
Sbjct: 742 KQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLA- 800
Query: 362 DLQDTRDALLKAADLETTFEERVLIQKLVRAISRRXXXXXXXXXXXXXXKTNALNQSYHC 421
L R A+L+ L +T ++ +L++ + +SRR K
Sbjct: 801 -LLQVR-AILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRL 858
Query: 422 QVEVGCDGSVVEHYPGFRSMMRHAL-ALSPIGPEGERDVHLRISKDGSGVGAAL 474
V VG DG++ + +P F +M + LSP + +V +S+DGSG GAAL
Sbjct: 859 NVTVGVDGTLYKLHPHFSRIMHQTVKELSP-----KCNVSFLLSEDGSGKGAAL 907
Score = 194 bits (494), Expect = 2e-49
Identities = 151/484 (31%), Positives = 234/484 (48%), Gaps = 53/484 (10%)
Query: 4 PKLTKAVDSICDQFI----VTKSKISQLTEYFIDCMEKGLEPCESDISQNKGLPMIPTFV 59
PKL +S D+++ ++ + + F M+ GL D + + M+PTFV
Sbjct: 16 PKLHLLAESEIDKYLYAMRLSDETLIDIMTRFRKEMKNGLS---RDFNPTATVKMLPTFV 72
Query: 60 TDKPSGQEHGVTMLAADLGGTNFRVCSVELLGNHE----FKIEQEKSKIPTFFFQDDHHV 115
P G E G +A DLGG++FR+ V++ NHE +E E P ++ H
Sbjct: 73 RSIPDGSEKG-DFIALDLGGSSFRILRVQV--NHEKNQNVHMESEVYDTP----ENIVHG 125
Query: 116 TSKDLFQHMALITHQFLTKHHKDVIQDYKWKMGFTFSYPVDQTSLSSGKLIRWTKGFKIG 175
+ LF H+A F+ K I+D K +GFTFS+P Q+ + LI WTK FK
Sbjct: 126 SGSQLFDHVAECLGDFMEKRK---IKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKAS 182
Query: 176 DTVGQDVVQLFQQELNDIGLSNVHVVALTNDTTGTLLARCYASSDAARAINEPVIGCIFG 235
G DVV+L + + G + ++VA+ NDT GT++ Y +G I G
Sbjct: 183 GVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQHCE-------VGLIIG 235
Query: 236 TGTNGCYMEKLENIHKLDPASREELLSQGKTHMCINTEWGSF--DNELNHLPTTSYDIKI 293
TGTN CYME+L +I +L+ + MCINTEWG+F D L + T +D +I
Sbjct: 236 TGTNACYMEELRHI---------DLVEGDEGRMCINTEWGAFGDDGSLEDI-RTEFDREI 285
Query: 294 DQQFSTNPGFHLFEKRVSGLYLGEILRNILLDLEKQELFDLKESVLKNNPFILTTETLSH 353
D+ S NPG LFEK VSG+YLGE++R IL+ + K+ L L E + P +LT +
Sbjct: 286 DRG-SLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGL--LFEG--RITPELLTRGKFNT 340
Query: 354 IEIDTVENDLQDTRDA--LLKAADLETTFEERVLIQKLVRAISRRXXXXXXXXXXXXXXK 411
++ +E + + +A +L +E + ++ V +Q + +S R +
Sbjct: 341 SDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVSFRSANLVAATLGAILNR 400
Query: 412 TNALNQSYHCQVEVGCDGSVVEHYPGFRSMMRHAL-ALSPIGPEGERDVHLRISKDGSGV 470
+ + VG DGS+ + +P + L L P + DV +S+ GSG
Sbjct: 401 LRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVP-----DSDVRFLLSESGSGK 455
Query: 471 GAAL 474
GAA+
Sbjct: 456 GAAM 459
>Hs15991827 [G] KOG1369 Hexokinase
Length = 916
Score = 214 bits (544), Expect = 3e-55
Identities = 162/474 (34%), Positives = 235/474 (49%), Gaps = 45/474 (9%)
Query: 8 KAVDSICDQFIVTKSKISQLTEYFIDCMEKGLEPCESDISQNKGLPMIPTFVTDKPSGQE 67
+ ++ F +TK + ++ + ME GL N + M+P+FV P G E
Sbjct: 467 RQIEETLAHFHLTKDMLLEVKKRMRAEMELGLR---KQTHNNAVVKMLPSFVRRTPDGTE 523
Query: 68 HGVTMLAADLGGTNFRVCSVELLGNHEFKIEQEKS--KIPTFFFQDDHHVTSKDLFQHMA 125
+G LA DLGGTNFRV V++ + +E IP Q T ++LF H+
Sbjct: 524 NG-DFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQG----TGEELFDHIV 578
Query: 126 LITHQFLTKHHKDVIQDYKWKMGFTFSYPVDQTSLSSGKLIRWTKGFKIGDTVGQDVVQL 185
FL I+ + +GFTFS+P QTSL +G LI WTKGFK D VG DVV L
Sbjct: 579 SCISDFLDYMG---IKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTL 635
Query: 186 FQQELNDIGLSNVHVVALTNDTTGTLLARCYASSDAARAINEPV--IGCIFGTGTNGCYM 243
+ + ++ VVA+ NDT GT++ Y EP +G I GTG+N CYM
Sbjct: 636 LRDAIKRREEFDLDVVAVVNDTVGTMMTCAY---------EEPTCEVGLIVGTGSNACYM 686
Query: 244 EKLENIHKLDPASREELLSQGKTHMCINTEWGSF-DNELNHLPTTSYDIKIDQQFSTNPG 302
E+++N+ E++ + MCIN EWG+F DN T YD +D ++S N G
Sbjct: 687 EEMKNV---------EMVEGDQGQMCINMEWGAFGDNGCLDDIRTHYDRLVD-EYSLNAG 736
Query: 303 FHLFEKRVSGLYLGEILRNILLDLEKQE-LFDLKESVLKNNPFILTTETLSHIEIDTVEN 361
+EK +SG+YLGEI+RNIL+D K+ LF + S I T+ LS IE D +
Sbjct: 737 KQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETLKTRGIFETKFLSQIESDRLA- 795
Query: 362 DLQDTRDALLKAADLETTFEERVLIQKLVRAISRRXXXXXXXXXXXXXXKTNALNQSYHC 421
L R A+L+ L +T ++ +L++ + +SRR K
Sbjct: 796 -LLQVR-AILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRL 853
Query: 422 QVEVGCDGSVVEHYPGFRSMMRHAL-ALSPIGPEGERDVHLRISKDGSGVGAAL 474
V VG DG++ + +P F +M + LSP + +V +S+DGSG GAAL
Sbjct: 854 NVTVGVDGTLYKLHPHFSRIMHQTVKELSP-----KCNVSFLLSEDGSGKGAAL 902
Score = 192 bits (488), Expect = 9e-49
Identities = 145/449 (32%), Positives = 220/449 (48%), Gaps = 49/449 (10%)
Query: 35 MEKGLEPCESDISQNKGLPMIPTFVTDKPSGQEHGVTMLAADLGGTNFRVCSVELLGNHE 94
M+ GL D + + M+PTFV P G E G +A DLGG++FR+ V++ NHE
Sbjct: 46 MKNGLS---RDFNPTATVKMLPTFVRSIPDGSEKG-DFIALDLGGSSFRILRVQV--NHE 99
Query: 95 ----FKIEQEKSKIPTFFFQDDHHVTSKDLFQHMALITHQFLTKHHKDVIQDYKWKMGFT 150
+E E P ++ H + LF H+A F+ K I+D K +GFT
Sbjct: 100 KNQNVHMESEVYDTP----ENIVHGSGSQLFDHVAECLGDFMEKRK---IKDKKLPVGFT 152
Query: 151 FSYPVDQTSLSSGKLIRWTKGFKIGDTVGQDVVQLFQQELNDIGLSNVHVVALTNDTTGT 210
FS+P Q+ + LI WTK FK G DVV+L + + G + ++VA+ NDT GT
Sbjct: 153 FSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGT 212
Query: 211 LLARCYASSDAARAINEPVIGCIFGTGTNGCYMEKLENIHKLDPASREELLSQGKTHMCI 270
++ Y +G I GTGTN CYME+L +I +L+ + MCI
Sbjct: 213 MMTCGYDDQHCE-------VGLIIGTGTNACYMEELRHI---------DLVEGDEGRMCI 256
Query: 271 NTEWGSF--DNELNHLPTTSYDIKIDQQFSTNPGFHLFEKRVSGLYLGEILRNILLDLEK 328
NTEWG+F D L + T +D +ID+ S NPG LFEK VSG+YLGE++R IL+ + K
Sbjct: 257 NTEWGAFGDDGSLEDI-RTEFDREIDRG-SLNPGKQLFEKMVSGMYLGELVRLILVKMAK 314
Query: 329 QELFDLKESVLKNNPFILTTETLSHIEIDTVENDLQDTRDA--LLKAADLETTFEERVLI 386
+ L L E + P +LT + ++ +E + + +A +L +E + ++ V +
Sbjct: 315 EGL--LFEG--RITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSV 370
Query: 387 QKLVRAISRRXXXXXXXXXXXXXXKTNALNQSYHCQVEVGCDGSVVEHYPGFRSMMRHAL 446
Q + +S R + + + VG DGS+ + +P + L
Sbjct: 371 QHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTL 430
Query: 447 -ALSPIGPEGERDVHLRISKDGSGVGAAL 474
L P + DV +S+ GSG GAA+
Sbjct: 431 RRLVP-----DSDVRFLLSESGSGKGAAM 454
>Hs4504391 [G] KOG1369 Hexokinase
Length = 917
Score = 213 bits (542), Expect = 5e-55
Identities = 161/474 (33%), Positives = 235/474 (48%), Gaps = 45/474 (9%)
Query: 8 KAVDSICDQFIVTKSKISQLTEYFIDCMEKGLEPCESDISQNKGLPMIPTFVTDKPSGQE 67
+ ++ F +TK + ++ + ME GL N + M+P+FV P G E
Sbjct: 468 RQIEETLAHFHLTKDMLLEVKKRMRAEMELGLR---KQTHNNAVVKMLPSFVRRTPDGTE 524
Query: 68 HGVTMLAADLGGTNFRVCSVELLGNHEFKIEQEKS--KIPTFFFQDDHHVTSKDLFQHMA 125
+G LA DLGGTNFRV V++ + +E IP Q T ++LF H+
Sbjct: 525 NG-DFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQG----TGEELFDHIV 579
Query: 126 LITHQFLTKHHKDVIQDYKWKMGFTFSYPVDQTSLSSGKLIRWTKGFKIGDTVGQDVVQL 185
FL I+ + +GFTFS+P QTSL +G LI WTKGFK D VG DVV L
Sbjct: 580 SCISDFLDYMG---IKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTL 636
Query: 186 FQQELNDIGLSNVHVVALTNDTTGTLLARCYASSDAARAINEPV--IGCIFGTGTNGCYM 243
+ + ++ VVA+ NDT GT++ Y EP +G I GTG+N CYM
Sbjct: 637 LRDAIKRREEFDLDVVAVVNDTVGTMMTCAY---------EEPTCEVGLIVGTGSNACYM 687
Query: 244 EKLENIHKLDPASREELLSQGKTHMCINTEWGSF-DNELNHLPTTSYDIKIDQQFSTNPG 302
E+++N+ E++ + MCIN EWG+F DN T YD ++ ++S N G
Sbjct: 688 EEMKNV---------EMVEGDQGQMCINMEWGAFGDNGCLDDIRTHYD-RLVNEYSLNAG 737
Query: 303 FHLFEKRVSGLYLGEILRNILLDLEKQE-LFDLKESVLKNNPFILTTETLSHIEIDTVEN 361
+EK +SG+YLGEI+RNIL+D K+ LF + S I T+ LS IE D +
Sbjct: 738 KQRYEKMISGMYLGEIVRNILIDFTKKGFLFRGQISETMKTRGIFETKFLSQIESDRLA- 796
Query: 362 DLQDTRDALLKAADLETTFEERVLIQKLVRAISRRXXXXXXXXXXXXXXKTNALNQSYHC 421
L R A+L+ L +T ++ +L++ + +SRR K
Sbjct: 797 -LLQVR-AILQQLGLNSTCDDSILVKTVCGVVSRRAAQLCGAGMAAVVDKIRENRGLDRL 854
Query: 422 QVEVGCDGSVVEHYPGFRSMMRHAL-ALSPIGPEGERDVHLRISKDGSGVGAAL 474
V VG DG++ + +P F +M + LSP + +V +S+DGSG GAAL
Sbjct: 855 NVTVGVDGTLYKLHPHFSRIMHQTVKELSP-----KCNVSFLLSEDGSGKGAAL 903
Score = 192 bits (488), Expect = 9e-49
Identities = 145/449 (32%), Positives = 220/449 (48%), Gaps = 49/449 (10%)
Query: 35 MEKGLEPCESDISQNKGLPMIPTFVTDKPSGQEHGVTMLAADLGGTNFRVCSVELLGNHE 94
M+ GL D + + M+PTFV P G E G +A DLGG++FR+ V++ NHE
Sbjct: 47 MKNGLS---RDFNPTATVKMLPTFVRSIPDGSEKG-DFIALDLGGSSFRILRVQV--NHE 100
Query: 95 ----FKIEQEKSKIPTFFFQDDHHVTSKDLFQHMALITHQFLTKHHKDVIQDYKWKMGFT 150
+E E P ++ H + LF H+A F+ K I+D K +GFT
Sbjct: 101 KNQNVHMESEVYDTP----ENIVHGSGSQLFDHVAECLGDFMEKRK---IKDKKLPVGFT 153
Query: 151 FSYPVDQTSLSSGKLIRWTKGFKIGDTVGQDVVQLFQQELNDIGLSNVHVVALTNDTTGT 210
FS+P Q+ + LI WTK FK G DVV+L + + G + ++VA+ NDT GT
Sbjct: 154 FSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGT 213
Query: 211 LLARCYASSDAARAINEPVIGCIFGTGTNGCYMEKLENIHKLDPASREELLSQGKTHMCI 270
++ Y +G I GTGTN CYME+L +I +L+ + MCI
Sbjct: 214 MMTCGYDDQHCE-------VGLIIGTGTNACYMEELRHI---------DLVEGDEGRMCI 257
Query: 271 NTEWGSF--DNELNHLPTTSYDIKIDQQFSTNPGFHLFEKRVSGLYLGEILRNILLDLEK 328
NTEWG+F D L + T +D +ID+ S NPG LFEK VSG+YLGE++R IL+ + K
Sbjct: 258 NTEWGAFGDDGSLEDI-RTEFDREIDRG-SLNPGKQLFEKMVSGMYLGELVRLILVKMAK 315
Query: 329 QELFDLKESVLKNNPFILTTETLSHIEIDTVENDLQDTRDA--LLKAADLETTFEERVLI 386
+ L L E + P +LT + ++ +E + + +A +L +E + ++ V +
Sbjct: 316 EGL--LFEG--RITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSV 371
Query: 387 QKLVRAISRRXXXXXXXXXXXXXXKTNALNQSYHCQVEVGCDGSVVEHYPGFRSMMRHAL 446
Q + +S R + + + VG DGS+ + +P + L
Sbjct: 372 QHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTL 431
Query: 447 -ALSPIGPEGERDVHLRISKDGSGVGAAL 474
L P + DV +S+ GSG GAA+
Sbjct: 432 RRLVP-----DSDVRFLLSESGSGKGAAM 455
>Hs15553127 [G] KOG1369 Hexokinase
Length = 917
Score = 211 bits (538), Expect = 1e-54
Identities = 155/472 (32%), Positives = 231/472 (48%), Gaps = 45/472 (9%)
Query: 10 VDSICDQFIVTKSKISQLTEYFIDCMEKGLEPCESDISQNKGLPMIPTFVTDKPSGQEHG 69
VD ++ + ++++ F MEKGL + K M+PTFV P G EHG
Sbjct: 22 VDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAAVK---MLPTFVRSTPDGTEHG 78
Query: 70 VTMLAADLGGTNFRVCSVELLGNHEFKIEQEKS--KIPTFFFQDDHHVTSKDLFQHMALI 127
LA DLGGTNFRV V++ N K+E E IP +D + LF H+A
Sbjct: 79 -EFLALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIP----EDIMRGSGTQLFDHIAEC 133
Query: 128 THQFLTKHHKDVIQDYKWKMGFTFSYPVDQTSLSSGKLIRWTKGFKIGDTVGQDVVQLFQ 187
F+ K I+D K +GFTFS+P QT L L+ WTKGFK G+DVV L +
Sbjct: 134 LANFMDKLQ---IKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIR 190
Query: 188 QELNDIGLSNVHVVALTNDTTGTLLARCYASSDAARAINEPVIGCIFGTGTNGCYMEKLE 247
+ + G ++ +VA+ NDT GT++ Y + IG I GTG+N CYME++
Sbjct: 191 KAIQRRGDFDIDIVAVVNDTVGTMMTCGYDDHNCE-------IGLIVGTGSNACYMEEMR 243
Query: 248 NIHKLDPASREELLSQGKTHMCINTEWGSF--DNELNHLPTTSYDIKIDQQFSTNPGFHL 305
+I +++ + MCIN EWG+F D LN + T +D +ID S NPG L
Sbjct: 244 HI---------DMVEGDEGRMCINMEWGAFGDDGSLNDI-RTEFDQEIDMG-SLNPGKQL 292
Query: 306 FEKRVSGLYLGEILRNILLDLEKQELF---DLKESVLKNNPFILTTETLSHIEIDTVEND 362
FEK +SG+Y+GE++R IL+ + K+EL L +L F ET +I+ ++
Sbjct: 293 FEKMISGMYMGELVRLILVKMAKEELLFGGKLSPELLNTGRF----ETKDISDIEGEKDG 348
Query: 363 LQDTRDALLKAADLETTFEERVLIQKLVRAISRRXXXXXXXXXXXXXXKTNALNQSYHCQ 422
++ R+ L++ L+ T E+ V ++ + +S R + +
Sbjct: 349 IRKAREVLMRLG-LDPTQEDCVATHRICQIVSTRSASLCAATLAAVLQRIKENKGEERLR 407
Query: 423 VEVGCDGSVVEHYPGFRSMMRHALALSPIGPEGERDVHLRISKDGSGVGAAL 474
+G DGSV + +P F + + G DV S+DGSG GAA+
Sbjct: 408 STIGVDGSVYKKHPHFAKRLHKTVRRLVPG----CDVRFLRSEDGSGKGAAM 455
Score = 201 bits (511), Expect = 2e-51
Identities = 149/445 (33%), Positives = 222/445 (49%), Gaps = 41/445 (9%)
Query: 35 MEKGLEPCESDISQNKGLPMIPTFVTDKPSGQEHGVTMLAADLGGTNFRVCSVELLGNHE 94
ME+GL + + + M+PT+V P G E G LA DLGGTNFRV V +
Sbjct: 495 MERGLS---KETHASAPVKMLPTYVCATPDGTEKG-DFLALDLGGTNFRVLLVRVRNGKW 550
Query: 95 FKIEQEKS--KIPTFFFQDDHHVTSKDLFQHMALITHQFLTKHHKDVIQDYKWKMGFTFS 152
+E IP Q+ H T +LF H+ FL ++ +GFTFS
Sbjct: 551 GGVEMHNKIYAIP----QEVMHGTGDELFDHIVQCIADFLEYMG---MKGVSLPLGFTFS 603
Query: 153 YPVDQTSLSSGKLIRWTKGFKIGDTVGQDVVQLFQQELNDIGLSNVHVVALTNDTTGTLL 212
+P Q SL L++WTKGFK G+DVV L ++ ++ ++ VVA+ NDT GT++
Sbjct: 604 FPCQQNSLDESILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVGTMM 663
Query: 213 ARCYASSDAARAINEPVIGCIFGTGTNGCYMEKLENIHKLDPASREELLSQGKTHMCINT 272
+ +G I GTG+N CYME++ N+ EL+ + MC+N
Sbjct: 664 TCGFEDPHCE-------VGLIVGTGSNACYMEEMRNV---------ELVEGEEGRMCVNM 707
Query: 273 EWGSF-DNELNHLPTTSYDIKIDQQFSTNPGFHLFEKRVSGLYLGEILRNILLDLEKQE- 330
EWG+F DN T +D+ +D + S NPG FEK +SG+YLGEI+RNIL+D K+
Sbjct: 708 EWGAFGDNGCLDDFRTEFDVAVD-ELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGL 766
Query: 331 LFDLKESVLKNNPFILTTETLSHIEIDTVENDLQDTRDALLKAADLETTFEERVLIQKLV 390
LF + S I T+ LS IE D + L R A+L+ LE+T ++ ++++++
Sbjct: 767 LFRGRISERLKTRGIFETKFLSQIESDCLA--LLQVR-AILQHLGLESTCDDSIIVKEVC 823
Query: 391 RAISRRXXXXXXXXXXXXXXKTNALNQSYHCQVEVGCDGSVVEHYPGFRSMMRHALA-LS 449
++RR + +V VG DG++ + +P F +M + L+
Sbjct: 824 TVVARRAAQLCGAGMAAVVDRIRENRGLDALKVTVGVDGTLYKLHPHFAKVMHETVKDLA 883
Query: 450 PIGPEGERDVHLRISKDGSGVGAAL 474
P + DV S+DGSG GAAL
Sbjct: 884 P-----KCDVSFLQSEDGSGKGAAL 903
>At2g19860 [G] KOG1369 Hexokinase
Length = 502
Score = 209 bits (532), Expect = 7e-54
Identities = 161/443 (36%), Positives = 225/443 (50%), Gaps = 41/443 (9%)
Query: 52 LPMIPTFVTDKPSGQEHGVTMLAADLGGTNFRVCSVELLGNHEFKIEQE--KSKIPTFFF 109
L M+ ++V + PSG E G A DLGGTNFRV V L G H+ +++E + IP
Sbjct: 78 LKMLISYVDNLPSGDETGF-FYALDLGGTNFRVMRVLLGGKHDRVVKREFKEESIPPHLM 136
Query: 110 QDDHHVTSKDLFQHMALITHQFLTKHHKD--VIQDYKWKMGFTFSYPVDQTSLSSGKLIR 167
H +LF + + +F+ +D + + ++GFTFS+PV Q SLSSG LI
Sbjct: 137 TGKSH----ELFDFIVDVLAKFVATEGEDFHLPPGRQRELGFTFSFPVKQLSLSSGTLIN 192
Query: 168 WTKGFKIGDTVGQDVVQLFQQELNDIGLSNVHVVALTNDTTGTLLARCYASSDAARAINE 227
WTKGF I DTV +DVV + + +GL ++ V AL NDT GTL Y + D
Sbjct: 193 WTKGFSIDDTVDKDVVGELVKAMERVGL-DMLVAALVNDTIGTLAGGRYTNPDV------ 245
Query: 228 PVIGCIFGTGTNGCYMEKLENI---HKLDPASREELLSQGKTHMCINTEWGSFDNELNHL 284
V+ I GTGTN Y+E+ I H L P S E M IN EWG+F + +HL
Sbjct: 246 -VVAVILGTGTNAAYVERAHAIPKWHGLLPKSGE---------MVINMEWGNFRS--SHL 293
Query: 285 PTTSYDIKIDQQFSTNPGFHLFEKRVSGLYLGEILRNILLDLEKQELF--DLKESVLKNN 342
P T YD +D S NPG + EK +SG+YLGEILR +LL + ++ F D+ LK
Sbjct: 294 PLTEYDHSLDVD-SLNPGEQILEKIISGMYLGEILRRVLLKMAEEAAFFGDIVPPKLK-I 351
Query: 343 PFILTTETLSHIEIDTVENDLQDTRDALLKAADLET-TFEERVLIQKLVRAISRRXXXXX 401
PFI+ T +S + DT DL+ L +++T + + R ++ L I+ R
Sbjct: 352 PFIIRTPNMSAMHSDT-SPDLKVVGSKLKDILEVQTSSLKMRKVVISLCNIIASRGARLS 410
Query: 402 XXXXXXXXXK--TNALNQSYHCQVEVGCDGSVVEHYPGFRSMMRHALALSPIGPEGERDV 459
K +A + + DG + EHY F M+ +L +G E V
Sbjct: 411 AAGIYGILKKIGRDATKDGEAQKSVIAMDGGLFEHYTQFSESMKSSLK-ELLGDEVSESV 469
Query: 460 HLRISKDGSGVGAA-LCALHANY 481
+ +S DGSGVGAA L A H+ Y
Sbjct: 470 EVILSNDGSGVGAALLAASHSQY 492
>At1g47840 [G] KOG1369 Hexokinase
Length = 493
Score = 208 bits (529), Expect = 2e-53
Identities = 156/431 (36%), Positives = 219/431 (50%), Gaps = 30/431 (6%)
Query: 52 LPMIPTFVTDKPSGQEHGVTMLAADLGGTNFRVCSVELLGNHEFKIEQEKSKIPTFFFQD 111
L MI TFV PSG E G+ A DLGGTNFRV SV+L G E + E +I Q
Sbjct: 81 LEMILTFVDALPSGNEEGL-FYALDLGGTNFRVRSVQLGGKKERVLATESEQIS--ISQK 137
Query: 112 DHHVTSKDLFQHMALITHQFLTKHHKD---VIQDYKWKMGFTFSYPVDQTSLSSGKLIRW 168
TS++LF +A F+ K + + K ++GFTFS+PV QTS+ SG L +W
Sbjct: 138 LMIGTSEELFGFIASKLANFVAKEKPGRFLLEEGRKRELGFTFSFPVKQTSIDSGTLSKW 197
Query: 169 TKGFKIGDTVGQDVVQLFQQELNDIGLSNVHVVALTNDTTGTLLARCYASSDAARAINEP 228
TKGFK+ G++VV + + GL ++ V AL ND GTL Y D
Sbjct: 198 TKGFKVSGMEGKNVVACLNEAMEAHGL-DMRVSALVNDGVGTLAGARYWDEDV------- 249
Query: 229 VIGCIFGTGTNGCYMEKLENIHKLDPASREELLSQGKTHMCINTEWGSFDNELNHLPTTS 288
++G I GTGTN CY+E+ I KL S S G T INTEWG F LP T
Sbjct: 250 MVGVILGTGTNACYVEQKHAIPKLRSKS-----SSGTT--IINTEWGGFS---KILPQTI 299
Query: 289 YDIKIDQQFSTNPGFHLFEKRVSGLYLGEILRNILLDL-EKQELFDLKESVLKNNPFILT 347
+D+++D+ S NPG HL+EK +SG+YLGEI+R +LL + E +LF + P L
Sbjct: 300 FDLEMDET-SLNPGEHLYEKMISGMYLGEIVRRVLLHMCETSDLFGHFAPAKLSTPLALR 358
Query: 348 TETLSHIEIDTVENDLQDTRDALLKAADLETTFEERVLIQKLVRAISRRXXXXXXXXXXX 407
TE L ++ D + DL+D L D++ R + ++ + +R
Sbjct: 359 TEHLCKMQEDNTD-DLRDVGSILYDFLDVKANMNARRRVVEVCDTVVKRGGRLAGAGIVA 417
Query: 408 XXXK--TNALNQSYHCQVEVGCDGSVVEHYPGFRSMMRHALALSPIGPEGERDVHLRISK 465
K + + V DG++ E YP +R M+ AL + +G + V ++ +K
Sbjct: 418 ILEKIEKDTKRMGSGKRTVVAMDGALYEKYPQYRQYMQDAL-VELLGHKLASHVAIKHTK 476
Query: 466 DGSGVGAALCA 476
D SG+GAAL A
Sbjct: 477 DVSGLGAALLA 487
>7291070 [G] KOG1369 Hexokinase
Length = 541
Score = 207 bits (527), Expect = 3e-53
Identities = 154/481 (32%), Positives = 233/481 (48%), Gaps = 43/481 (8%)
Query: 1 MSDPKLTKAVDSICDQFIVTKSKISQLTEYFIDCMEKGLEPCESDISQNKGLPMIPTFVT 60
+S + +K V +C Q ++T ++ +L + + +GL D + T+V
Sbjct: 86 LSAAEKSKMVHELCQQLLLTDEQVQELCYRILHELRRGLA---KDTHPKANVKCFVTYVQ 142
Query: 61 DKPSGQEHGVTMLAADLGGTNFRVCSVELLGNHEFKIEQEKSKIPTFFFQDDHHVTSKDL 120
D P+G E G LA DLGGTNFRV + L N++F++E IP + L
Sbjct: 143 DLPNGNERG-KFLALDLGGTNFRVLLIHLQENNDFQMESRIYAIPQHIMIG----SGTQL 197
Query: 121 FQHMALITHQFLTKHHKDVIQDYKWKMGFTFSYPVDQTSLSSGKLIRWTKGFKIGDTVGQ 180
F H+A F+ +H+ + + +GFTFS+P+ Q L+ G L WTKGF V +
Sbjct: 198 FDHIAECLSNFMAEHN---VYKERLPLGFTFSFPLRQLGLTKGLLETWTKGFNCAGVVNE 254
Query: 181 DVVQLFQQELNDIGLSNVHVVALTNDTTGTLLARCYASSDAARAINEPVIGCIFGTGTNG 240
DVVQL + + G + V A+ NDTTGTL++ + + + IG I GTG N
Sbjct: 255 DVVQLLKDAIARRGDVQIDVCAILNDTTGTLMSCAWKNHNCK-------IGLIVGTGANA 307
Query: 241 CYMEKLENIHKL---DPASREELLSQGKTHMCINTEWGSF-DNELNHLPTTSYDIKIDQQ 296
CYME++E DP K H+ INTEWG+F DN T +D ID
Sbjct: 308 CYMERVEEAELFAAEDPR---------KKHVLINTEWGAFGDNGALDFVRTEFDRDIDVH 358
Query: 297 FSTNPGFHLFEKRVSGLYLGEILRNILLDLEKQE-LFDLKESVLKNNPFILTTETLSHIE 355
S NPG FEK +SG+Y+GE++R +L+ + + LF+ ++S + N + T+ +S IE
Sbjct: 359 -SINPGKQTFEKMISGMYMGELVRLVLVKMTQAGILFNGQDSEVLNTRGLFFTKYVSEIE 417
Query: 356 IDTVENDLQDTRDALLKAADLETTFEERVLIQKLVRAISRRXXXXXXXXXXXXXXKTNAL 415
D N + R L + T + ++ + +S+R +
Sbjct: 418 ADEPGN-FTNCRLVLEELGLTNATDGDCANVRYICECVSKRAAHLVSAGI------ATLI 470
Query: 416 NQSYHCQVEVGCDGSVVEHYPGFRSMMRHALALSPIGPEGERDVHLRISKDGSGVGAALC 475
N+ V VG DGSV +P F ++M ++ I P D L +S+DGSG GAAL
Sbjct: 471 NKMDEPTVTVGVDGSVYRFHPKFHNLMVEKIS-QLIKPGITFD--LMLSEDGSGRGAALV 527
Query: 476 A 476
A
Sbjct: 528 A 528
>At4g29130 [G] KOG1369 Hexokinase
Length = 496
Score = 207 bits (526), Expect = 4e-53
Identities = 159/437 (36%), Positives = 223/437 (50%), Gaps = 40/437 (9%)
Query: 52 LPMIPTFVTDKPSGQEHGVTMLAADLGGTNFRVCSVELLGNHEFKIEQEKSKIPTFFFQD 111
L M+ ++V + PSG E G+ A DLGGTNFRV V L G E ++QE ++
Sbjct: 78 LKMLISYVDNLPSGDEKGL-FYALDLGGTNFRVMRVLLGGKQERVVKQEFEEVSI----P 132
Query: 112 DHHVT--SKDLFQHMALITHQFLTKHHKD--VIQDYKWKMGFTFSYPVDQTSLSSGKLIR 167
H +T S +LF +A +F+ +D + + + ++GFTFS+PV QTSLSSG LI+
Sbjct: 133 PHLMTGGSDELFNFIAEALAKFVATECEDFHLPEGRQRELGFTFSFPVKQTSLSSGSLIK 192
Query: 168 WTKGFKIGDTVGQDVVQLFQQELNDIGLSNVHVVALTNDTTGTLLARCYASSDAARAINE 227
WTKGF I + VGQDVV + L +GL ++ + AL NDT GTL Y + D A+
Sbjct: 193 WTKGFSIEEAVGQDVVGALNKALERVGL-DMRIAALVNDTVGTLAGGRYYNPDVVAAV-- 249
Query: 228 PVIGCIFGTGTNGCYMEKLENI---HKLDPASREELLSQGKTHMCINTEWGSFDNELNHL 284
I GTGTN Y+E+ I H L P S E M IN EWG+F + +HL
Sbjct: 250 -----ILGTGTNAAYVERATAIPKWHGLLPKSGE---------MVINMEWGNFRS--SHL 293
Query: 285 PTTSYDIKIDQQFSTNPGFHLFEKRVSGLYLGEILRNILLDLEKQELF--DLKESVLKNN 342
P T +D +D + S NPG + EK +SG+YLGEILR +LL + + F D S L+
Sbjct: 294 PLTEFDHTLDFE-SLNPGEQILEKIISGMYLGEILRRVLLKMAEDAAFFGDTVPSKLR-I 351
Query: 343 PFILTTETLSHIEIDTVENDLQDTRDALLKAADLETT-FEERVLIQKLVRAISRRXXXXX 401
PFI+ T +S + DT DL+ + ++ TT + R ++ L I+ R
Sbjct: 352 PFIIRTPHMSAMHNDT-SPDLKIVGSKIKDILEVPTTSLKMRKVVISLCNIIATRGARLS 410
Query: 402 XXXXXXXXXK--TNALNQSYHCQVEVGCDGSVVEHYPGFRSMMRHALALSPIGPEGERDV 459
K + + + DG + EHY F M +L +G E V
Sbjct: 411 AAGIYGILKKLGRDTTKDEEVQKSVIAMDGGLFEHYTQFSECMESSLK-ELLGDEASGSV 469
Query: 460 HLRISKDGSGVGAALCA 476
+ S DGSG+GAAL A
Sbjct: 470 EVTHSNDGSGIGAALLA 486
>At1g50460 [G] KOG1369 Hexokinase
Length = 498
Score = 201 bits (510), Expect = 3e-51
Identities = 151/440 (34%), Positives = 227/440 (51%), Gaps = 43/440 (9%)
Query: 52 LPMIPTFVTDKPSGQEHGVTMLAADLGGTNFRVCSVELLGNHEFKIEQ---EKSKIPTFF 108
L M+ TFV D P+G+E G T A LGGT FR+ V LLG+ ++ E+ IP+
Sbjct: 78 LKMLLTFVDDLPTGREKG-TYYALHLGGTYFRILRV-LLGDQRSYLDVQDVERHPIPSHL 135
Query: 109 FQDDHHVTSKDLFQHMALITHQFLTKHHKDV-IQDYKWKMGFTFSYPVDQTSLSSGKLIR 167
TS+ LF +A +F+ K Q + ++ FTFS+PV TS+SSG LI+
Sbjct: 136 MNS----TSEVLFNFLAFSLERFIEKEENGSDSQGVRRELAFTFSFPVKHTSISSGVLIK 191
Query: 168 WTKGFKIGDTVGQDVVQLFQQELNDIGLSNVHVVALTNDTTGTLLARCYASSDAARAINE 227
WTKGF+I + VGQD+ + Q LN GL ++HV AL NDT G L Y D
Sbjct: 192 WTKGFEISEMVGQDIAECLQGALNRRGL-DMHVAALVNDTVGALSLGYYHDPDT------ 244
Query: 228 PVIGCIFGTGTNGCYMEKLENIHKLDPASREELLSQGKTHMCINTEWGSFDNELNHLPTT 287
V+ +FGTG+N CY+E+ + I K L + G M +N EWG+F + +HLP T
Sbjct: 245 -VVAVVFGTGSNACYLERTDAIIKCQGL----LTTSGS--MVVNMEWGNFWS--SHLPRT 295
Query: 288 SYDIKIDQQFSTNPGFHLFEKRVSGLYLGEILRNILLDL-EKQELFDLKESVLKNNPFIL 346
SYDI +D + S+N FEK +SG+YLG+I+R ++L + E ++F VL + P++L
Sbjct: 296 SYDIDLDAE-SSNANDMGFEKMISGMYLGDIVRRVILRMSEDSDIFGPISPVL-SEPYVL 353
Query: 347 TTETLSHIEIDTVENDLQDTRDALLKAADLETTFEERVLIQKLVRAISRRXXXXXXXXXX 406
T ++S I D +LQ+ L + + R L+ K+ ++RR
Sbjct: 354 RTNSVSAIHEDDTP-ELQEVARILKDIGVSDVPLKVRKLVVKICDVVTRRAGRLAAAGIA 412
Query: 407 XXXXK---------TNALNQS---YHCQVEVGCDGSVVEHYPGFRSMMRHALALSPIGPE 454
K T+ ++S + V +G + +Y FR M AL + +G E
Sbjct: 413 GILKKIGRDGSGGITSGRSRSEIQMQKRTVVAVEGGLYMNYTMFREYMEEAL-VEILGEE 471
Query: 455 GERDVHLRISKDGSGVGAAL 474
+ V ++ +DGS +G+AL
Sbjct: 472 VSQYVVVKAMEDGSSIGSAL 491
>7303093 [G] KOG1369 Hexokinase
Length = 454
Score = 200 bits (508), Expect = 4e-51
Identities = 150/485 (30%), Positives = 247/485 (50%), Gaps = 45/485 (9%)
Query: 6 LTKAVDSICDQFIVTKSKISQLTEYFIDCMEKGLEPCESDISQNKGLPMIPTFVTDKPSG 65
L V + F+++ ++ ++ F + +GL+ + PT+V D P+G
Sbjct: 2 LDAEVRELMQPFVLSDYQVQEVYSRFCLEVARGLK---RSTHPQANVKCFPTYVQDLPTG 58
Query: 66 QEHGVTMLAADLGGTNFRVCSVELLGNHEFKIEQEKSKIPTFFFQDDHHVTSKDLFQHMA 125
E G LA DLGGTNFRV V L G+H+ ++ + +P +D DLF H+A
Sbjct: 59 DEMG-KYLALDLGGTNFRVLLVSLKGHHDATVDSQIYAVP----KDLMVGPGVDLFDHIA 113
Query: 126 LITHQFLTKHHKDVIQDYKWKMGFTFSYPVDQTSLSSGKLIRWTKGFKIGDTVGQDVVQL 185
+F+ KH D+ Y +GFTFS+P Q L G L+RWTKGF G+DV ++
Sbjct: 114 GCLAKFVEKH--DMKTAYL-PLGFTFSFPCVQLGLKEGILVRWTKGFDCAGVEGEDVGRM 170
Query: 186 FQQELNDIGLSNVHVVALTNDTTGTLLARCYASSDAARAINEPVIGCIFGTGTNGCYMEK 245
+ + G +++ VVA+ NDTTGTL++ + ++D +G I GTG N CY+E
Sbjct: 171 LHEAIQRRGDADIAVVAILNDTTGTLMSCAHRNADCR-------VGVIVGTGCNACYVED 223
Query: 246 LENIHKLDPASREELLSQGKTHMCINTEWGSF--DNELNHLPTTSYDIKIDQQFSTNPGF 303
+EN+ L ++ K + +N EWG+F +L+ + T YD ++D++ S N
Sbjct: 224 VENVDLLRADFKKT-----KRSVIVNAEWGAFGEGGQLDFV-RTEYDREVDEK-SLNRSE 276
Query: 304 HLFEKRVSGLYLGEILRNILL-DLEKQELFDLKE------SVLKNNPFILTTETLSHIEI 356
LFEK +G+YLG ++R +LL LE++ +F SVL+ N + T +S IE
Sbjct: 277 QLFEKMTAGMYLGNLVRLVLLRALERKLIFKQSSRRPEFASVLQRNEEVFETRYISEIED 336
Query: 357 DTVENDLQDTRDALLKAADLE-TTFEERVLIQKLVRAISRRXXXXXXXXXXXXXXKTNAL 415
D+ + TR + LE + E+ ++ + +++R + +
Sbjct: 337 DSFP-EFASTRKIVKNLFGLEKASVEDCQTLRYICECVAKRAATLVAIGV------SGLV 389
Query: 416 NQSYHCQVEVGCDGSVVEHYPGFRSMMRHALALSPIGPEGERDVHLRISKDGSGVGAALC 475
N++ + +V VG DGSV ++P F + MR L + +++ + +S+DGSG GAAL
Sbjct: 390 NRTSNRRVIVGMDGSVYRYHPKFDAYMRQTLQKL---VKADKEWDIMLSEDGSGRGAALV 446
Query: 476 ALHAN 480
A A+
Sbjct: 447 AAVAS 451
>Hs4504395 [G] KOG1369 Hexokinase
Length = 923
Score = 196 bits (499), Expect = 5e-50
Identities = 154/442 (34%), Positives = 214/442 (47%), Gaps = 42/442 (9%)
Query: 35 MEKGLEPCESDISQNKGLPMIPTFVTDKPSGQEHGVTMLAADLGGTNFRVCSVELLGNHE 94
M KGL + L M+PTFV P G E G LA DLGGTNFRV V +
Sbjct: 508 MAKGLR------GEASSLRMLPTFVRATPDGSERG-DFLALDLGGTNFRVLLVRVTTG-- 558
Query: 95 FKIEQEKSKIPTFFFQDDHHVTSKDLFQHMALITHQFLTKHHKDVIQDYKWKMGFTFSYP 154
+I E IP Q + + LF H+ F K + +GFTFS+P
Sbjct: 559 VQITSEIYSIPETVAQG----SGQQLFDHIVDCIVDF---QQKQGLSGQSLPLGFTFSFP 611
Query: 155 VDQTSLSSGKLIRWTKGFKIGDTVGQDVVQLFQQELNDIGLSNVHVVALTNDTTGTLLAR 214
Q L G L+ WTKGFK D GQDVV L ++ + ++VVA+ NDT GT+++
Sbjct: 612 CRQLGLDQGILLNWTKGFKASDCEGQDVVSLLREAITRRQAVELNVVAIVNDTVGTMMSC 671
Query: 215 CYASSDAARAINEPVIGCIFGTGTNGCYMEKLENIHKLDPASREELLSQGKTHMCINTEW 274
Y IG I GTGTN CYME+L N+ + S MCIN EW
Sbjct: 672 GYEDPRCE-------IGLIVGTGTNACYMEELRNVAGVPGDS---------GRMCINMEW 715
Query: 275 GSF-DNELNHLPTTSYDIKIDQQFSTNPGFHLFEKRVSGLYLGEILRNILLDLEK-QELF 332
G+F D+ + +T +D +DQ S NPG FEK +SG+YLGEI+R+ILL L LF
Sbjct: 716 GAFGDDGSLAMLSTRFDASVDQA-SINPGKQRFEKMISGMYLGEIVRHILLHLTSLGVLF 774
Query: 333 DLKESVLKNNPFILTTETLSHIEIDTVENDLQDTRDALLKAADLETTFEERVLIQKLVRA 392
++ I T+ LS IE D++ L+ R A+L+ L T ++ +++ ++ +A
Sbjct: 775 RGQQIQRLQTRDIFKTKFLSEIESDSLA--LRQVR-AILEDLGLPLTSDDALMVLEVCQA 831
Query: 393 ISRRXXXXXXXXXXXXXXKTNALNQSYHCQVEVGCDGSVVEHYPGFRSMMRHALALSPIG 452
+S+R K V VG DG++ + +P F S++ A + +
Sbjct: 832 VSQRAAQLCGAGVAAVVEKIRGNRGLEELAVSVGVDGTLYKLHPRFSSLV--AATVRELA 889
Query: 453 PEGERDVHLRISKDGSGVGAAL 474
P V S+DGSG GAAL
Sbjct: 890 PRCV--VTFLQSEDGSGKGAAL 909
Score = 162 bits (410), Expect = 1e-39
Identities = 137/476 (28%), Positives = 213/476 (43%), Gaps = 45/476 (9%)
Query: 7 TKAVDSICDQFIVTKSKISQLTEYFIDCMEKGLEPCESDISQNKGLPMIPTFVTDKPSGQ 66
++ V QF VT++++ Q+ + ME+ L S + M+PT+V P G
Sbjct: 30 SELVQECLQQFKVTRAQLQQIQASLLGSMEQALR---GQASPAPAVRMLPTYVGSTPHGT 86
Query: 67 EHGVTMLAADLG--GTNFRVCSVELLGNHEFKIEQEKSK--IPTFFFQDDHHVTSKDLFQ 122
E G + +LG G + RV V L G ++E + IP Q+ + LF
Sbjct: 87 EQG-DFVVLELGATGASLRVLWVTLTGIEGHRVEPRSQEFVIP----QEVMLGAGQQLFD 141
Query: 123 HMALITHQFLTKHHKDVIQDYKWKMGFTFSYPVDQTSLSSGKLIRWTKGFKIGDTVGQDV 182
A +FL + ++GF+FS+P QT L LI WTKGF+ GQDV
Sbjct: 142 FAAHCLSEFLDAQP---VNKQGLQLGFSFSFPCHQTGLDRSTLISWTKGFRCSGVEGQDV 198
Query: 183 VQLFQQELNDIGLSNVHVVALTNDTTGTLLARCYASSDAARAINEPVIGCIFGTGTNGCY 242
VQL + + G N+ VVA+ NDT GT++ + +G + TGTN CY
Sbjct: 199 VQLLRDAIRRQGAYNIDVVAVVNDTVGTMMG-------CEPGVRPCEVGLVVDTGTNACY 251
Query: 243 MEKLENIHKLDPASREELLSQGKTHMCINTEWGSFDNELNHLPT-TSYDIKIDQQFSTNP 301
ME+ ++ LD + + +C++ EWGS ++ P T++D +D + S NP
Sbjct: 252 MEEARHVAVLD---------EDRGRVCVSVEWGSLSDDGALGPVLTTFDHTLDHE-SLNP 301
Query: 302 GFHLFEKRVSGLYLGEILRNILLDLEK-QELFDLKESVLKNNPFILTTETLSHIEIDTVE 360
G FEK + GLYLGE++R +L L + LF S P +L+ ++ + +E
Sbjct: 302 GAQRFEKMIGGLYLGELVRLVLAHLARCGVLFGGCTS-----PALLSQGSILLEHVAEME 356
Query: 361 NDLQDTR--DALLKAADLETTFEERVLIQKLVRAISRRXXXXXXXXXXXXXXKTNALNQS 418
+ A+L+ L + L+Q + A+ R +
Sbjct: 357 DPSTGAARVHAILQDLGLSPGASDVELVQHVCAAVCTRAAQLCAAALAAVLSCLQHSREQ 416
Query: 419 YHCQVEVGCDGSVVEHYPGFRSMMRHALALSPIGPEGERDVHLRISKDGSGVGAAL 474
QV V G V E +P F S+++ + L + P E DV L S DG G G A+
Sbjct: 417 QTLQVAVATGGRVCERHPRFCSVLQGTVML--LAP--ECDVSLIPSVDGGGRGVAM 468
>At3g20040 [G] KOG1369 Hexokinase
Length = 488
Score = 195 bits (495), Expect = 1e-49
Identities = 143/428 (33%), Positives = 219/428 (50%), Gaps = 36/428 (8%)
Query: 52 LPMIPTFVTDKPSGQEHGVTMLAADLGGTNFRVCSVELLGNHEFKIEQ--EKSKIPTFFF 109
L M+ TFV D P+G E G T A LGG+ FR+ V L G Q E+ IPT
Sbjct: 78 LKMLLTFVDDLPNGSETG-TYYALHLGGSYFRIIKVHLGGQRSSLEVQDVERHSIPTSLM 136
Query: 110 QDDHHVTSKDLFQHMALITHQFLTKHHKD--VIQDYKWKMGFTFSYPVDQTSLSSGKLIR 167
TS+ LF +A +F+ K D + Q K ++ FTFS+PV QTS+SSG LI+
Sbjct: 137 NS----TSEVLFDFLASSLQRFIEKEGNDFSLSQPLKRELAFTFSFPVKQTSISSGVLIK 192
Query: 168 WTKGFKIGDTVGQDVVQLFQQELNDIGLSNVHVVALTNDTTGTLLARCYASSDAARAINE 227
WTKGF I + G+D+ + Q LN GL ++ V AL NDT G L + D A+
Sbjct: 193 WTKGFAISEMAGEDIAECLQGALNKRGL-DIRVAALVNDTVGALSFGHFHDPDTIAAV-- 249
Query: 228 PVIGCIFGTGTNGCYMEKLENIHKLDPASREELLSQGKTHMCINTEWGSFDNELNHLPTT 287
+FGTG+N CY+E+ + I K + + G M +N EWG+F + + LP T
Sbjct: 250 -----VFGTGSNACYLERTDAIIK----CQNPRTTSGS--MVVNMEWGNFWS--SRLPRT 296
Query: 288 SYDIKIDQQFSTNPGFHLFEKRVSGLYLGEILRNILLDL-EKQELFDLKESVLKNNPFIL 346
SYD+++D + S N FEK + G+YLG+I+R ++L + ++ ++F S+L + PF+L
Sbjct: 297 SYDLELDAE-SMNSNDMGFEKMIGGMYLGDIVRRVILRMSQESDIFGPISSIL-STPFVL 354
Query: 347 TTETLSHIEIDTVENDLQDTRDALLKAADLETTFEERVLIQKLVRAISRRXXXXXXXXXX 406
T ++S + D ++LQ+ L E + R L+ K+ ++RR
Sbjct: 355 RTNSVSAMHEDDT-SELQEVARILKDLGVSEVPMKVRKLVVKICDVVTRRAARLAAAGI- 412
Query: 407 XXXXKTNALNQSYHCQVEVGCDGSVVEHYPGFRSMMRHALALSPIGPEGERDVHLRISKD 466
L + + V +G + +Y FR M AL +G + + V ++ +D
Sbjct: 413 -----AGILKKQIMRRTVVAVEGGLYLNYRMFREYMDEALR-DILGEDVAQHVVVKAMED 466
Query: 467 GSGVGAAL 474
GS +G+AL
Sbjct: 467 GSSIGSAL 474
>CE18823 [G] KOG1369 Hexokinase
Length = 552
Score = 184 bits (466), Expect = 3e-46
Identities = 148/473 (31%), Positives = 232/473 (48%), Gaps = 40/473 (8%)
Query: 9 AVDSICDQFIVTKSKISQLTEYFIDCMEKGLEPCESDISQNKGLPMIPTFVTDKPSGQEH 68
+++S+ +F ++ + + ++ + D M++GLE S + ++ + M+P+FV + P+G+E
Sbjct: 46 SLESVMAEFKLSNTTLRRMMSHLSDNMDRGLE---SGLERST-IAMLPSFVPELPNGKER 101
Query: 69 GVTMLAADLGGTNFRVCSVELLGNHEFKIEQEKSKIPTFFFQDDHHVTSKDLFQHMALIT 128
G +A DLGGTN RV +EL + +Q +++P H T + LF ++A
Sbjct: 102 G-KFVAMDLGGTNLRVMLMELEPGEPMRTKQFNTRMPNAAM----HGTGQKLFDYIAKAL 156
Query: 129 HQFLTKHHKDVIQDYKWKMGFTFSYPVDQTSLSSGKLIRWTKGFKIGDTVGQDVVQLFQQ 188
FL + + D +GFTFSYP DQT L S L+RWTKG VG+DVVQL +
Sbjct: 157 CDFLVERE---LADEHLPVGFTFSYPCDQTGLRSATLLRWTKGVTATGCVGEDVVQLLED 213
Query: 189 ELNDIGLSNVHVVALTNDTTGTLLARCYASSDAARAINEPVIGCIFGTGTNGCYMEKLEN 248
+ G V++VAL NDT GT++A Y + IG I GTGTN YME
Sbjct: 214 AIARDGRVKVNIVALINDTVGTMVAAAYEAGGHCD------IGVIIGTGTNASYMEDSRK 267
Query: 249 I-HKLDPASREELLSQGKTHMCINTEWGSF-DNELNHLPTTSYDIKIDQQFSTNPGFHLF 306
I H L A+ + M I+TEWG F DN T YD +D + S +PG +
Sbjct: 268 IVHGLANATED----YNHKSMIIDTEWGGFGDNGEADYIFTRYDKIVDSK-SDHPGVNSL 322
Query: 307 EKRVSGLYLGEILRNILLDL-EKQELFDLKESVLKNNPFILTTETLSHIEIDTVENDLQD 365
+K ++G+ +GE++R +L L E + LF+ S + T+ +S I D +
Sbjct: 323 DKLIAGMCMGELVRLVLERLCENKVLFNGIGSKMLRTRNTFPTKYISEILHDDC-GVYSN 381
Query: 366 TRDALLKAADLETTFEERVLIQKLVRAISRRXXXXXXXXXXXXXXKTNALNQSYHCQVEV 425
TR + + TF + +L++++ +SRR LN+ + V
Sbjct: 382 TRQIMDELGIEGATFSDMLLLREVCVVVSRRSANLAAAAIAC------VLNRVRRPNMLV 435
Query: 426 GCDGSVVEHYPGFRSMMRHAL--ALSPIGPEGERDVHLRISKDGSGVGAALCA 476
DGS +++P F + + L P D + + DGSG GAAL A
Sbjct: 436 AIDGSTYKYHPFFNHWVCEKIRELLDP-----GLDFKIVQTGDGSGRGAALIA 483
>7301467 [G] KOG1369 Hexokinase
Length = 907
Score = 184 bits (466), Expect = 3e-46
Identities = 143/473 (30%), Positives = 226/473 (47%), Gaps = 38/473 (8%)
Query: 10 VDSICDQFIVTKSKISQLTEYFIDCMEKGLEPCESDISQNKGLPMIPTFVTDKPSGQEHG 69
+++ F++ + K++++ E ++ GL D + + V D P+G+E G
Sbjct: 463 IEAAVKGFLIDQEKMTEVVERMTKEIKMGLA---KDTHARAVIKCFVSHVQDLPTGKERG 519
Query: 70 VTMLAADLGGTNFRVCSVELLGNHEFKIEQEKSKIPTFFFQDDHHVTSKDLFQHMALITH 129
LA DLGG+NFRV V L+ N + + + P + K LF +A
Sbjct: 520 -KYLALDLGGSNFRVLLVNLISNSDVETMSKGYNFPQTLMSG----SGKALFDFLAECLS 574
Query: 130 QFLTKHHKDVIQDYKWKMGFTFSYPVDQTSLSSGKLIRWTKGFKIGDTVGQDVVQLFQQE 189
+F H +++ +GFTFS+P+ Q LS G L+ WTKGF VG++VV L Q+
Sbjct: 575 EFCHSHG---LENESLALGFTFSFPLQQQGLSKGILVAWTKGFSCEGVVGKNVVSLLQEA 631
Query: 190 LNDIGLSNVHVVALTNDTTGTLLARCYASSDAARAINEPVIGCIFGTGTNGCYMEKLENI 249
++ G ++ VA+ NDT GTL++ + + IG I GTG+N CY+EK N
Sbjct: 632 IDRRGDLKINTVAILNDTVGTLMSCAFYHPNCR-------IGLIVGTGSNACYVEKTVNA 684
Query: 250 HKLDPASREELLSQGKTHMCINTEWGSF-DNELNHLPTTSYDIKIDQQFSTNPGFHLFEK 308
E + K M IN EWG+F DN + TSYD +D + + NPG FEK
Sbjct: 685 ECF-----EGYQTSPKPSMIINCEWGAFGDNGVLEFVRTSYDKAVD-KVTPNPGKQTFEK 738
Query: 309 RVSGLYLGEILRNILLD-LEKQELFDLKESVLKNNPFILTTETLSHIEIDTVENDLQDTR 367
+SG+Y+GE++R ++ D + K +F S + T +S +E D + ++
Sbjct: 739 CISGMYMGELVRLVITDMIAKGFMFHGIISEKIQERWSFKTAYISDVESD-APGEYRNCN 797
Query: 368 DALLKAADLETTFEERVLIQKLVRAISRRXXXXXXXXXXXXXXKTNALNQSYHCQVEVGC 427
L + L ++ ++ + A+S R K N +N +V +G
Sbjct: 798 KVLSELGILGCQEPDKEALRYICEAVSSRSAKLCACGLVTIINKMN-IN-----EVAIGI 851
Query: 428 DGSVVEHYPGFRSMMR-HALALSPIGPEGERDVHLRISKDGSGVGAALCALHA 479
DGSV +P + M++ H L G + E L +S+DGSG GAAL A A
Sbjct: 852 DGSVYRFHPKYHDMLQYHMKKLLKPGVKFE----LVVSEDGSGRGAALVAATA 900
Score = 105 bits (263), Expect = 1e-22
Identities = 114/473 (24%), Positives = 197/473 (41%), Gaps = 51/473 (10%)
Query: 23 KISQLTEYFIDCMEKGLEPCESDISQNKG--------LPMIPTFVTDKPSGQEHGVTMLA 74
K+ +L ID +EK + +I+ +P ++V D P+G+E G LA
Sbjct: 16 KVCKLFNPSIDDLEKIKNAMDREITMGLSRDHHDRSTVPCHLSYVQDLPTGRERG-QFLA 74
Query: 75 ADLGGTNFRVCSVELLGNHEFKIEQEKSKIPTFFFQDDHHVTS---KDLFQHMALITHQF 131
++ TN R+ V+ + + +P H V + ++F +A F
Sbjct: 75 LEMMPTNCRIMLVKFSSERDIYTSSKCVIMP-------HTVAAGRGTEVFTFLATSIANF 127
Query: 132 LTKHHKDVIQDYKWKMGFTFSYPVDQTSLSSGKLIRWTKGFKIGDTVGQDVVQLFQQELN 191
+ + K V +D +G F++ + + +L G L+ WTK F +G+DVVQL + L
Sbjct: 128 VKE--KKVDKD-NLPLGIAFAFTLKKLALDVGILVSWTKEFGAQGAIGKDVVQLLRDALA 184
Query: 192 DIGLSNVHVVALTNDTTGTLLARCYASSDAARAINEPVIGCIFGTGTNGCYMEKLENIHK 251
+V V+ + N G+LLA C+A D IG I G+ N CY+E++E
Sbjct: 185 KFPEISVDVMGIINVGAGSLLALCWAQPDTR-------IGLIMGSIANSCYVERVERCET 237
Query: 252 LDPASREELLSQGKTHMCINTEWGSF-DNELNHLPTTSYDIKIDQQFSTNPGFHLFEKRV 310
+ +L M IN++W F D YD ++D + S NPG ++EK
Sbjct: 238 YEGDEYRKL-------MIINSDWAHFGDTGQLDFIRNEYDRQLDTE-SINPGTRIYEKFS 289
Query: 311 SGLYLGEILRNILLDLEKQELFDLKESVLKNNPFILTTETLSHIEIDTVENDLQDTRDAL 370
L +GE++R I+L L K ++ +I L + + + + D
Sbjct: 290 GALCMGELVRIIVLRLMKSGAIFAED----RRDYIGIQWKLDMVSLIEI---VSDPPGVY 342
Query: 371 LKAADLETTFEERVLIQKLVRAISRRXXXXXXXXXXXXXXKTNALNQSYHC-QVEVGCDG 429
KA ++ F R ++ + A+ + L Q+ + DG
Sbjct: 343 TKAQEVMDKFRIRHCKERDLAALKYICDTVTNRAAMLVASGVSCLIDRMRLPQISIAVDG 402
Query: 430 SVVEHYPGFRSMMRHALALSPIGPEGERDVHLRISKDGSGVGAALCA--LHAN 480
+ +P F +++ L + + I++D GVGAA+ A HAN
Sbjct: 403 GIYRLHPTFSTVLNKYTRLL---ADPNYNFEFVITQDSCGVGAAIMAGMAHAN 452
>Hs15967161 [G] KOG1369 Hexokinase
Length = 464
Score = 182 bits (463), Expect = 7e-46
Identities = 141/478 (29%), Positives = 229/478 (47%), Gaps = 43/478 (8%)
Query: 4 PKLTKAVDSICDQFIVTKSKISQLTEYFIDCMEKGLEPCESDISQNKGLPMIPTFVTDKP 63
P+ V+ I +F + + + ++ M++GL + + + M+PT+V P
Sbjct: 9 PQPNSQVEQILAEFQLQEEDLKKVMRRMQKEMDRGLR---LETHEEASVKMLPTYVRSTP 65
Query: 64 SGQEHGVTMLAADLGGTNFRVCSVEL----LGNHEFKIEQEKSKIPTFFFQDDHHVTSKD 119
G E G L+ DLGGTNFRV V++ G K + + IP +D T++
Sbjct: 66 EGSEVG-DFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIP----EDAMTGTAEM 120
Query: 120 LFQHMALITHQFLTKHHKDVIQDYKWKMGFTFSYPVDQTSLSSGKLIRWTKGFKIGDTVG 179
LF +++ FL KH ++ K +GFTFS+PV + G L+ WTKGFK G
Sbjct: 121 LFDYISECISDFLDKHQ---MKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEG 177
Query: 180 QDVVQLFQQELNDIGLSNVHVVALTNDTTGTLLARCYASSDAARAINEPVIGCIFGTGTN 239
+VV L + + G + VVA+ NDT T+++ CY ++ +G I GTG N
Sbjct: 178 NNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMIS-CYYED------HQCEVGMIVGTGCN 230
Query: 240 GCYMEKLENIHKLDPASREELLSQGKTHMCINTEWGSF--DNELNHLPTTSYDIKIDQQF 297
CYME+++N+ EL+ + MC+NTEWG+F EL+ YD +D+
Sbjct: 231 ACYMEEMQNV---------ELVEGDEGRMCVNTEWGAFGDSGELDEF-LLEYDRLVDES- 279
Query: 298 STNPGFHLFEKRVSGLYLGEILRNILLDL-EKQELFDLKESVLKNNPFILTTETLSHIEI 356
S NPG L+EK + G Y+GE++R +LL L ++ LF + S T +S +E
Sbjct: 280 SANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVES 339
Query: 357 DTVENDLQDTRDALLKAADLETTFEERVLIQKLVRAISRRXXXXXXXXXXXXXXKTNALN 416
DT D + + +L L + + ++++ ++S R +
Sbjct: 340 DT--GDRKQIYN-ILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESR 396
Query: 417 QSYHCQVEVGCDGSVVEHYPGFRSMMRHALALSPIGPEGERDVHLRISKDGSGVGAAL 474
++ VG DGSV + +P F+ R ++ + P E + S++GSG GAAL
Sbjct: 397 SEDVMRITVGVDGSVYKLHPSFKE--RFHASVRRLTPSCE--ITFIESEEGSGRGAAL 450
>Hs4503951 [G] KOG1369 Hexokinase
Length = 465
Score = 181 bits (459), Expect = 2e-45
Identities = 140/472 (29%), Positives = 227/472 (47%), Gaps = 43/472 (9%)
Query: 10 VDSICDQFIVTKSKISQLTEYFIDCMEKGLEPCESDISQNKGLPMIPTFVTDKPSGQEHG 69
V+ I +F + + + ++ M++GL + + + M+PT+V P G E G
Sbjct: 16 VEQILAEFQLQEEDLKKVMRRMQKEMDRGLR---LETHEEASVKMLPTYVRSTPEGSEVG 72
Query: 70 VTMLAADLGGTNFRVCSVEL----LGNHEFKIEQEKSKIPTFFFQDDHHVTSKDLFQHMA 125
L+ DLGGTNFRV V++ G K + + IP +D T++ LF +++
Sbjct: 73 -DFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIP----EDAMTGTAEMLFDYIS 127
Query: 126 LITHQFLTKHHKDVIQDYKWKMGFTFSYPVDQTSLSSGKLIRWTKGFKIGDTVGQDVVQL 185
FL KH ++ K +GFTFS+PV + G L+ WTKGFK G +VV L
Sbjct: 128 ECISDFLDKHQ---MKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGL 184
Query: 186 FQQELNDIGLSNVHVVALTNDTTGTLLARCYASSDAARAINEPVIGCIFGTGTNGCYMEK 245
+ + G + VVA+ NDT T+++ CY ++ +G I GTG N CYME+
Sbjct: 185 LRDAIKRRGDFEMDVVAMVNDTVATMIS-CYYED------HQCEVGMIVGTGCNACYMEE 237
Query: 246 LENIHKLDPASREELLSQGKTHMCINTEWGSF--DNELNHLPTTSYDIKIDQQFSTNPGF 303
++N+ EL+ + MC+NTEWG+F EL+ YD +D+ S NPG
Sbjct: 238 MQNV---------ELVEGDEGRMCVNTEWGAFGDSGELDEF-LLEYDRLVDES-SANPGQ 286
Query: 304 HLFEKRVSGLYLGEILRNILLDL-EKQELFDLKESVLKNNPFILTTETLSHIEIDTVEND 362
L+EK + G Y+GE++R +LL L ++ LF + S T +S +E DT D
Sbjct: 287 QLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDT--GD 344
Query: 363 LQDTRDALLKAADLETTFEERVLIQKLVRAISRRXXXXXXXXXXXXXXKTNALNQSYHCQ 422
+ + +L L + + ++++ ++S R + +
Sbjct: 345 RKQIYN-ILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMR 403
Query: 423 VEVGCDGSVVEHYPGFRSMMRHALALSPIGPEGERDVHLRISKDGSGVGAAL 474
+ VG DGSV + +P F+ R ++ + P E + S++GSG GAAL
Sbjct: 404 ITVGVDGSVYKLHPSFKE--RFHASVRRLTPSCE--ITFIESEEGSGRGAAL 451
>Hs15967159 [G] KOG1369 Hexokinase
Length = 466
Score = 181 bits (459), Expect = 2e-45
Identities = 140/472 (29%), Positives = 227/472 (47%), Gaps = 43/472 (9%)
Query: 10 VDSICDQFIVTKSKISQLTEYFIDCMEKGLEPCESDISQNKGLPMIPTFVTDKPSGQEHG 69
V+ I +F + + + ++ M++GL + + + M+PT+V P G E G
Sbjct: 17 VEQILAEFQLQEEDLKKVMRRMQKEMDRGLR---LETHEEASVKMLPTYVRSTPEGSEVG 73
Query: 70 VTMLAADLGGTNFRVCSVEL----LGNHEFKIEQEKSKIPTFFFQDDHHVTSKDLFQHMA 125
L+ DLGGTNFRV V++ G K + + IP +D T++ LF +++
Sbjct: 74 -DFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIP----EDAMTGTAEMLFDYIS 128
Query: 126 LITHQFLTKHHKDVIQDYKWKMGFTFSYPVDQTSLSSGKLIRWTKGFKIGDTVGQDVVQL 185
FL KH ++ K +GFTFS+PV + G L+ WTKGFK G +VV L
Sbjct: 129 ECISDFLDKHQ---MKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGL 185
Query: 186 FQQELNDIGLSNVHVVALTNDTTGTLLARCYASSDAARAINEPVIGCIFGTGTNGCYMEK 245
+ + G + VVA+ NDT T+++ CY ++ +G I GTG N CYME+
Sbjct: 186 LRDAIKRRGDFEMDVVAMVNDTVATMIS-CYYED------HQCEVGMIVGTGCNACYMEE 238
Query: 246 LENIHKLDPASREELLSQGKTHMCINTEWGSF--DNELNHLPTTSYDIKIDQQFSTNPGF 303
++N+ EL+ + MC+NTEWG+F EL+ YD +D+ S NPG
Sbjct: 239 MQNV---------ELVEGDEGRMCVNTEWGAFGDSGELDEF-LLEYDRLVDES-SANPGQ 287
Query: 304 HLFEKRVSGLYLGEILRNILLDL-EKQELFDLKESVLKNNPFILTTETLSHIEIDTVEND 362
L+EK + G Y+GE++R +LL L ++ LF + S T +S +E DT D
Sbjct: 288 QLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDT--GD 345
Query: 363 LQDTRDALLKAADLETTFEERVLIQKLVRAISRRXXXXXXXXXXXXXXKTNALNQSYHCQ 422
+ + +L L + + ++++ ++S R + +
Sbjct: 346 RKQIYN-ILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMR 404
Query: 423 VEVGCDGSVVEHYPGFRSMMRHALALSPIGPEGERDVHLRISKDGSGVGAAL 474
+ VG DGSV + +P F+ R ++ + P E + S++GSG GAAL
Sbjct: 405 ITVGVDGSVYKLHPSFKE--RFHASVRRLTPSCE--ITFIESEEGSGRGAAL 452
>CE25610 [G] KOG1369 Hexokinase
Length = 451
Score = 128 bits (321), Expect = 2e-29
Identities = 127/481 (26%), Positives = 212/481 (43%), Gaps = 51/481 (10%)
Query: 6 LTKAVDSICDQFIVTKSKISQLTEYFIDCMEKGLEPCESDISQNKGLPMIPTFVTDKPSG 65
L V+ I +F + + ++ +++E M+ GL +Q + M+P++V P G
Sbjct: 4 LPPEVEEILAKFRLNREQLQEISEKVEQQMKMGLAK-----TQGSSIAMLPSYVPALPDG 58
Query: 66 QEHGVTMLAADLGGTNFRVCSVELLGNHEFKIEQEKSKIPTFFFQDDHHV---TSKDLFQ 122
E G +A DL G N R+ + + G + + I +HV T LF
Sbjct: 59 TETG-KYVAIDLSGKNLRIMLLTMNGAGTTPTHETVNYIVA------NHVMKGTGDQLFT 111
Query: 123 HMALITHQFLTKHHKDVIQDYKWKMGFTFSYPVDQTSLSSGKLIRWTKGFKIGDTVGQDV 182
+ +FL + + D +GF FSYP + S+ S +L+ WTKGF I D + +D+
Sbjct: 112 FIVNCLQRFLQEFG---LVDANLPIGFVFSYPCELLSIRSARLLWWTKGFDIKDCLQRDI 168
Query: 183 VQLFQQELNDIGLSNVHVVALTNDTTGTLLARCYASSDAARAINEPVIGCIFGTGTNGCY 242
V L ++ L + V + A+ NDT G L A + E IG + G G N Y
Sbjct: 169 VALLEEALEMNMSTKVSIKAVMNDTVGQLAAAAHKYGP------ECTIGVVIGYGCNSSY 222
Query: 243 MEKLENIHKLDPASREELLSQGKTHMCINTEWGSF--DNELNHLPTTSYDIKIDQQFSTN 300
+EK I K D +R +M + TEW F EL+ + T +D ++D S +
Sbjct: 223 LEKTSRITKFDAKAR----GYDHDNMIVVTEWEEFGKHGELDDI-LTQFDREVDAA-SVH 276
Query: 301 PGFHLFEKRVSGLYLGEILRNILLDLE-KQELFDLKESVLKNNPFILTTETLSHIEIDTV 359
G L +K LY+GE++R +L L + LF+ + + T+ +S I +
Sbjct: 277 KGKQLIDKLCGALYIGEVVRRVLSQLVLDRVLFEGQSCEKLDEDESFPTKYISEI-LGEE 335
Query: 360 ENDLQDTRDALLKAADLETTFE---ERVLIQKLVRAISRRXXXXXXXXXXXXXXKTNALN 416
E + R +LE + ++I+++ ISRR L
Sbjct: 336 EGVFKACRRI---CEELEVEMHGTGDYIIIREVCDVISRRGASIVAAAISA------LLR 386
Query: 417 QSYHCQVEVGCDGSVVEHYPGFRSMMRHAL-ALSPIGPEGERDVHLRISKDGSGVGAALC 475
V++G G++++ +P + M++ L L+PI + E L + +GS GAAL
Sbjct: 387 HLELSSVKIGVGGALIQFHPTYHQMLKEKLEELTPITMKFE----LVPADEGSCQGAALI 442
Query: 476 A 476
A
Sbjct: 443 A 443
>Hs13376711 [G] KOG1369 Hexokinase
Length = 325
Score = 121 bits (303), Expect = 3e-27
Identities = 85/264 (32%), Positives = 129/264 (48%), Gaps = 28/264 (10%)
Query: 8 KAVDSICDQFIVTKSKISQLTEYFIDCMEKGLEPCESDISQNKGLPMIPTFVTDKPSGQE 67
K +D + F +T+ ++ + +E GL+ ++ + M+PT+V P G E
Sbjct: 57 KQIDRVLALFQLTREQLVDVQAKMRAELEYGLKKKSHGLATVR---MLPTYVCGLPDGTE 113
Query: 68 HGVTMLAADLGGTNFRVCSVELL-GNHEFKIEQEKSKIPTFFFQDDHHVTSKDLFQHMAL 126
G LA DLGGTNFRV V++ G ++ + IP Q T ++LF H+
Sbjct: 114 KG-KFLALDLGGTNFRVLLVKIRSGRRSVRMYNKIFAIPLEIMQG----TGEELFDHIVQ 168
Query: 127 ITHQFLTKHHKDVIQDYKWKMGFTFSYPVDQTSLSSGKLIRWTKGFKIGDTVGQDVVQLF 186
FL ++ +GFTFS+P Q S+ G LI WTKGFK D G+DVV +
Sbjct: 169 CIADFLDYMG---LKGASLPLGFTFSFPCRQMSIDKGTLIGWTKGFKATDCEGEDVVDML 225
Query: 187 QQELNDIGLSNVHVVALTNDTTGTLLARCYASSDAARAINEPVIGCIFGTGTNGCYMEKL 246
++ + ++ +VA+ NDT GT++ Y + IG I GTG+N CYME +
Sbjct: 226 REAIKRRNEFDLDIVAVVNDTVGTMMTCGYEDPNCE-------IGLIAGTGSNMCYMEDM 278
Query: 247 ENIHKLDPASREELLSQGKTHMCI 270
NI E++ G+ MCI
Sbjct: 279 RNI---------EMVEGGEGKMCI 293
>At4g37840 [G] KOG1369 Hexokinase
Length = 493
Score = 116 bits (291), Expect = 7e-26
Identities = 117/429 (27%), Positives = 189/429 (43%), Gaps = 30/429 (6%)
Query: 52 LPMIPTFVTDKPSGQEHGVTMLAADLGGTNFRVCSVELLGNHEFKIEQEKSKIPTFFFQD 111
L M+ +F PSG E GV +L G + L GN E + +K +IP D
Sbjct: 79 LNMLVSFTGSLPSGDEKGVHY-GVNLRGKELLLLRGTLGGNEEPISDVQKHEIP--IPDD 135
Query: 112 DHHVTSKDLFQHMALITHQFLTKHHKDVIQDYKWKMGFTFSYPVDQT-SLSSGKLIRWTK 170
+ + K+L ++L +FL + ++ K +GFT + V+Q S S + R +
Sbjct: 136 VLNGSFKELCDFISLELVKFLAMNPGGEAEEVK-NLGFTLTRSVEQIGSHSISSIHRKSL 194
Query: 171 GFKIGDTVGQDVVQLFQQELNDIGLSNVHVVALTNDTTGTLLARCYASSDAARAINEPVI 230
+ V +D+V + L GL AL ++T G L Y D A++
Sbjct: 195 ANDDDEKVLKDLVNDMNESLETHGLKIRMNTALVDNTIGELAGGRYYHKDTVAAVS---- 250
Query: 231 GCIFGTGTNGCYMEKLENIHKLDPASREELLSQGKTHMCINTEWGSFDNELNHLPTTSYD 290
G GTN Y+E+ + I + A RE + ++TEWG F + HLP T +D
Sbjct: 251 ---LGMGTNAAYIEQAQEISRWKSAIREP------QEIVVSTEWGDFRS--CHLPITEFD 299
Query: 291 IKIDQQFSTNPGFHLFEKRVSGLYLGEILRNILLDL-EKQELFDLKESVLKNNPFILTTE 349
+D + S NPG +FEK VSG YLGEI+R +LL + E+ LF P+IL +
Sbjct: 300 ASLDAE-SLNPGHRIFEKMVSGRYLGEIVRRVLLKMSEESALFGDTLPPKLTIPYILWSP 358
Query: 350 TLSHIEIDTVENDLQDTRDALLKA--ADLETTFEERVLIQKLVRAISRRXXXXXXXXXXX 407
++ + D E ++T + LK +++T R ++ ++ ++ R
Sbjct: 359 DMAAMHQDISEE--RETVNKKLKEVFGIMDSTLAAREVVVEVCDVVAERAARLAGAGIVG 416
Query: 408 XXXKTNALNQSYHCQVEVGCDGSVVEHYPGFRSMMRHALALSPIGPEGERDVHLRISKDG 467
K L + + +G + +HY FR+ + H+ +G E V + S G
Sbjct: 417 MIKKLGRLEKKMSIVI---VEGGLYDHYRVFRNYL-HSSVWEMLGDELSDHVVIEHSHGG 472
Query: 468 SGVGAALCA 476
S GA A
Sbjct: 473 SAAGALFLA 481
>At1g47860_3 [G] KOG1369 Hexokinase
Length = 318
Score = 67.4 bits (163), Expect = 5e-11
Identities = 44/97 (45%), Positives = 59/97 (60%), Gaps = 7/97 (7%)
Query: 270 INTEWGSFDNELNHLPTTSYDIKIDQQFSTNPGFHLFEKRVSGLYLGEILRNILLDL-EK 328
INTEWG F L P T +D ++D + S N G HL+EK VSG+YLGEI+R +LL + E
Sbjct: 2 INTEWGGFSKVL---PQTIFDQEMDAE-SPNRGEHLYEKMVSGMYLGEIVRRVLLQMCET 57
Query: 329 QELF-DLKESVLKNNPFILTTETLSHIEIDTVENDLQ 364
+LF + PF L TE L+ ++ DT + DLQ
Sbjct: 58 SDLFGQFVPGGNLSKPFALKTEHLNKMQEDTTD-DLQ 93
>ECU11g1540 [G] KOG1369 Hexokinase
Length = 475
Score = 54.3 bits (129), Expect = 4e-07
Identities = 65/280 (23%), Positives = 120/280 (42%), Gaps = 36/280 (12%)
Query: 71 TMLAADLGGTNFRVCSVEL-LGNHEFKIEQEKSKI----PTFF-FQDDHHVTSKDLFQHM 124
++L D+GGT+ ++ V + LG+ E I P+F+ + D V+ +D
Sbjct: 86 SVLVIDVGGTSLKISEVVIDLGSDEKGNSPSFHDIVECSPSFYRYPDTSGVSGQDRISWN 145
Query: 125 ALITHQFLTKHHKDVIQDYKWKMGFTFSYPVDQTSLSSGKLIRWTKGFKIGD---TVGQD 181
+ Q + + ++ + K TFSYP+ QTS+++ ++ + TK F + T D
Sbjct: 146 EWVADQVVEFYGRNPPRS-KVNASLTFSYPLIQTSVNNAQIKKTTKNFCFREDEATFTTD 204
Query: 182 VVQLFQQELNDIGLSNVHVVALTNDTTGTLLARCYASSDAARAINEPVIGCIFGTGTNGC 241
+V+ L + NV V + ND+T T +A + +IG + GTGTN
Sbjct: 205 IVEALNSSLRSRKI-NVCVNCVLNDSTATYMAGVLRG-------YKNIIGIVLGTGTNSS 256
Query: 242 YMEKLENIHKLDPASREELLSQGKTHMCINTEWGSFDNELNHLPTTSYDIKIDQQFSTNP 301
+ K +++ + N+EWGS + L + +D +
Sbjct: 257 FCVKKGRSNEV---------------VLYNSEWGSTRVPRSMLTEADLAVVVDLEM-RKI 300
Query: 302 GFHLFEKRVSGLYLGEILRNILLDL--EKQELFDLKESVL 339
++ + G LG+I+ + L + E E + +E VL
Sbjct: 301 SHNIIDVLAGGCKLGDIVLHKLRNTYPEIYEEYAEREEVL 340
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.319 0.136 0.400
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,573,699
Number of Sequences: 60738
Number of extensions: 1251325
Number of successful extensions: 3019
Number of sequences better than 1.0e-05: 30
Number of HSP's better than 0.0 without gapping: 25
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 2746
Number of HSP's gapped (non-prelim): 40
length of query: 481
length of database: 30,389,216
effective HSP length: 110
effective length of query: 371
effective length of database: 23,708,036
effective search space: 8795681356
effective search space used: 8795681356
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)