ORF STATUS Function Best COG Functional category Pathways and functional systems
r_klactIII0526 good P KOG1172 Inorganic ion transport and metabolism Na+-independent Cl/HCO3 exchanger AE1 and related transporters (SLC4 family)
Only best alignment is shown:
BLASTP 2.2.3 [May-13-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= r_klactIII0526 173935 175611 559
(559 letters)
Database: KOG eukaryal database 04/03
60,738 sequences; 30,389,216 total letters
Searching..................................................done
Color Key for Alignment Scores: 
Score E
Sequences producing significant alignments: (bits) Value
YNL275w [P] KOG1172 Na+-independent Cl/HCO3 exchanger AE1 and re... 734 0.0
SPBC543.05c [P] KOG1172 Na+-independent Cl/HCO3 exchanger AE1 an... 469 e-132
At2g47160 [P] KOG1172 Na+-independent Cl/HCO3 exchanger AE1 and ... 208 2e-53
Hs4507021 [P] KOG1172 Na+-independent Cl/HCO3 exchanger AE1 and ... 177 4e-44
Hs4827016 [P] KOG1172 Na+-independent Cl/HCO3 exchanger AE1 and ... 174 2e-43
Hs21361551 [P] KOG1172 Na+-independent Cl/HCO3 exchanger AE1 and... 174 4e-43
HsM4507023 [P] KOG1172 Na+-independent Cl/HCO3 exchanger AE1 and... 173 7e-43
At1g15460 [P] KOG1172 Na+-independent Cl/HCO3 exchanger AE1 and ... 173 7e-43
At3g62270 [P] KOG1172 Na+-independent Cl/HCO3 exchanger AE1 and ... 170 5e-42
At4g32510 [P] KOG1172 Na+-independent Cl/HCO3 exchanger AE1 and ... 166 1e-40
7297232 [P] KOG1172 Na+-independent Cl/HCO3 exchanger AE1 and re... 164 2e-40
At3g06450 [P] KOG1172 Na+-independent Cl/HCO3 exchanger AE1 and ... 158 2e-38
At1g74810 [P] KOG1172 Na+-independent Cl/HCO3 exchanger AE1 and ... 156 9e-38
At5g25430 [P] KOG1172 Na+-independent Cl/HCO3 exchanger AE1 and ... 149 1e-35
CE28476 [P] KOG1172 Na+-independent Cl/HCO3 exchanger AE1 and re... 145 1e-34
7294876 [P] KOG1172 Na+-independent Cl/HCO3 exchanger AE1 and re... 142 2e-33
Hs14042960 [P] KOG1172 Na+-independent Cl/HCO3 exchanger AE1 and... 131 2e-30
Hs11545763 [P] KOG1172 Na+-independent Cl/HCO3 exchanger AE1 and... 129 9e-30
CE28743 [P] KOG1172 Na+-independent Cl/HCO3 exchanger AE1 and re... 126 8e-29
CE27167 [P] KOG1172 Na+-independent Cl/HCO3 exchanger AE1 and re... 111 3e-24
Hs4507025 [P] KOG1172 Na+-independent Cl/HCO3 exchanger AE1 and ... 109 1e-23
Hs22049645 [P] KOG1172 Na+-independent Cl/HCO3 exchanger AE1 and... 102 1e-21
CE28338 [P] KOG1172 Na+-independent Cl/HCO3 exchanger AE1 and re... 101 3e-21
Hs19743830 [P] KOG1172 Na+-independent Cl/HCO3 exchanger AE1 and... 101 3e-21
Hs19743827 [P] KOG1172 Na+-independent Cl/HCO3 exchanger AE1 and... 101 3e-21
Hs19743825 [P] KOG1172 Na+-independent Cl/HCO3 exchanger AE1 and... 101 3e-21
Hs15042959 [P] KOG1172 Na+-independent Cl/HCO3 exchanger AE1 and... 101 3e-21
Hs19923176 [P] KOG1172 Na+-independent Cl/HCO3 exchanger AE1 and... 89 1e-17
Hs4759134 [P] KOG1172 Na+-independent Cl/HCO3 exchanger AE1 and ... 85 3e-16
>YNL275w [P] KOG1172 Na+-independent Cl/HCO3 exchanger AE1 and related
transporters (SLC4 family)
Length = 576
Score = 734 bits (1896), Expect = 0.0
Identities = 362/535 (67%), Positives = 434/535 (80%), Gaps = 1/535 (0%)
Query: 25 LDIASQKSKDSDVEIQSIEKPRKRFPPLCAGLIHDIKDKVPQYPSDWKDSWDYRVIPSVL 84
LD S S+ E + R+RFP L G+ D+KD++P Y SDW D+++YRVIPS++
Sbjct: 31 LDRESSVSESRSDEESHEKLSRRRFPTLGIGIWLDLKDRIPYYKSDWVDAFNYRVIPSIV 90
Query: 85 ETYFNNLLPALAFAQDMFDRTDNSYGVNEVLLSSAIAGLVFGIIGGQPLCIVGVTGPISI 144
+TYFNNLLPA+AFAQDMFDRTDNSYGVNEVLLSSA+AG+VFG++GGQPLCIVGVTGPISI
Sbjct: 91 DTYFNNLLPAIAFAQDMFDRTDNSYGVNEVLLSSAMAGIVFGVLGGQPLCIVGVTGPISI 150
Query: 145 FNYTVYEIIMPLNIDYFGFMFWICIWSMITHFLLVIVNSVCLLQYVTTFPCDIFGLFINV 204
FNYTVYEII PLN YFGFMFWIC+WSMI H +L N+VCLLQYVTTFPCDIFGLFINV
Sbjct: 151 FNYTVYEIIKPLNTSYFGFMFWICMWSMIFHLVLAFTNAVCLLQYVTTFPCDIFGLFINV 210
Query: 205 VYIQKGIQILTRQFVDENSDFNLASGYSSIMVALLMAIFGLAFKFFQLTPLLTYTMRTLI 264
VYIQKGIQILTRQF ++ + ++ G++S++VAL+M FGL FK F PL ++ +RT I
Sbjct: 211 VYIQKGIQILTRQFSAKSGEKSVQDGFASVVVALVMTAFGLFFKLFHYYPLFSHRIRTFI 270
Query: 265 SDYSTALSVVFWSGFIHFGGLLDSVSFQKLPITKAFAPTRHGDSRQ-TWLAYQDISVGDV 323
SDYSTALSV+FWS F HFGG L V F+KLPITKAF PT + Q TWLAY+ I V DV
Sbjct: 271 SDYSTALSVLFWSSFTHFGGYLHDVKFKKLPITKAFFPTSKVNRPQNTWLAYEPIPVKDV 330
Query: 324 FLALPFGIVLTILFYFDHNVSSLMAQRKEYKLRKASTFHYDFALLGITTGIAGVLGIPAP 383
F+ALPFGI LTILFYFDHNVSSLMAQR +YKL+K S+FHYDFALLG+TT I+GVLGIPAP
Sbjct: 331 FIALPFGIFLTILFYFDHNVSSLMAQRHQYKLKKPSSFHYDFALLGLTTCISGVLGIPAP 390
Query: 384 NGLIPQAPLHTQSLLVRDDDGNVIRCAEQRFTNTVQGLMILGTMTRPFLICLGLIPQAVL 443
NGLIPQAPLHT++LLVRD + VI C EQRFTNT QGLMILGTMTRP L+CLG IPQAVL
Sbjct: 391 NGLIPQAPLHTETLLVRDSNQKVISCVEQRFTNTFQGLMILGTMTRPLLVCLGEIPQAVL 450
Query: 444 SGLFFIMGIQGLVSNTIVHRIWFVFTDPKKKSKDSTLNTVSTKSLLLFISLSLVGFVAEF 503
SGLFFIMGI GL++N+I+ R+ F+F+DP ++ S L VS KS+L+F+S SL GF EF
Sbjct: 451 SGLFFIMGINGLMTNSIIQRLVFLFSDPNRRDNTSPLMKVSKKSMLIFLSFSLTGFAGEF 510
Query: 504 AITNTKGAIGFPIVLLLTVILSLFFPKIFPDKDLAILDEPVSEEFTLKNILPRNL 558
AITNT AIGFP+VLLL+V++S F IFP ++L ILD V+++FT+KN+L N+
Sbjct: 511 AITNTIAAIGFPLVLLLSVLVSFSFAYIFPTEELKILDTNVAQKFTIKNLLLENI 565
>SPBC543.05c [P] KOG1172 Na+-independent Cl/HCO3 exchanger AE1 and related
transporters (SLC4 family)
Length = 517
Score = 469 bits (1208), Expect = e-132
Identities = 245/503 (48%), Positives = 338/503 (66%), Gaps = 23/503 (4%)
Query: 56 LIHDIKDKVPQYPSDWKDSWDYRVIPSVLETYFNNLLPALAFAQDMFDRTDNSYGVNEVL 115
+++D+K ++P Y SDW D+ YRV+P+ L YF+NLLP LAFA DMF +T+NS+GVNEVL
Sbjct: 16 IVNDVKKRLPYYKSDWIDACHYRVLPACLNIYFSNLLPELAFALDMFAKTNNSFGVNEVL 75
Query: 116 LSSAIAGLVFGIIGGQPLCIVGVTGPISIFNYTVYEIIMPLNIDYFGFMFWICIWSMITH 175
L+S + +VF ++ QPLCIVGVTGPI++FNYTVY+I+ YF F+ WIC+WSMI H
Sbjct: 76 LASVLGSVVFALLSSQPLCIVGVTGPITVFNYTVYDIMHDRGTPYFPFLCWICLWSMIFH 135
Query: 176 FLLVIVNSVCLLQYVTTFPCDIFGLFINVVYIQKGIQILTRQFVDENSDFNLASGYSSIM 235
F++ I N V ++++T F C+IFGL++ +Y++KG+Q+L Q + L + + SI
Sbjct: 136 FIIAIANGVYFVKHITKFSCEIFGLYVAFIYLEKGVQVLCDQL-----KYGLTNTFLSIT 190
Query: 236 VALLMAIFGLAFKFFQLTPLLTYTMRTLISDYSTALSVVFWSGFIHFGGLLDSVSFQKLP 295
+ALL + G + L +Y +R L+ DY S++F+SGF H G + + VS KLP
Sbjct: 191 IALLFLMVGWLCDTVGKSSLFSYKVRILLLDYGLVASIIFFSGFQHIGKMRE-VSLAKLP 249
Query: 296 ITKAFAPTRHGDSRQTWLAYQDISVGDVFLALPFGIVLTILFYFDHNVSSLMAQRKEYKL 355
TKAF PT SR ++ + I VGDVFLA+PF IVLTILFYFDHNVSS+MAQ + L
Sbjct: 250 TTKAFEPTL---SRSWFIKFWKIPVGDVFLAIPFSIVLTILFYFDHNVSSVMAQDPSFPL 306
Query: 356 RKASTFHYDFALLGITTGIAGVLGIPAPNGLIPQAPLHTQSLLVRDDDGN---------- 405
K + FH+DF LLGITTG++G+LGIPAPNGLIPQAP+HT +L V+ D +
Sbjct: 307 TKPAGFHWDFFLLGITTGVSGILGIPAPNGLIPQAPMHTAALCVKRVDYDEDEIEKTHKE 366
Query: 406 -VIRCAEQRFTNTVQGLMILGTMTRPFLICLGLIPQAVLSGLFFIMGIQGLVSNTIVHRI 464
+ R EQR +N +QGLM +GTMT P L+ L IPQ VL+GLF++MG + N I +
Sbjct: 367 VIDRVVEQRASNFIQGLMTVGTMTGPLLLVLHQIPQCVLAGLFWVMGFSAIFGNGITQNV 426
Query: 465 WFVFTDPKKKSKDSTLNTVSTKSLL-LFISLSLVGFVAEFAITNT-KGAIGFPIVLLLTV 522
++ +D K SK+ TLN S+K ++ L+ L L+GF A FAIT K +IGFPI++LL +
Sbjct: 427 IWMLSDRKVVSKNHTLNHCSSKRVVWLYTILQLIGFGATFAITQVDKASIGFPIIILLLI 486
Query: 523 ILSLF-FPKIFPDKDLAILDEPV 544
+ PK F ++DL ILDE V
Sbjct: 487 PFRTYCMPKWFLEEDLEILDENV 509
>At2g47160 [P] KOG1172 Na+-independent Cl/HCO3 exchanger AE1 and related
transporters (SLC4 family)
Length = 542
Score = 208 bits (529), Expect = 2e-53
Identities = 144/521 (27%), Positives = 252/521 (47%), Gaps = 59/521 (11%)
Query: 55 GLIHDIKDKVPQYPSDWKDSWD--YRVIPSVLETYFNNLLPALAFAQDMFDRTDNSYGVN 112
G+ +D+K ++ Y DW + +R++ +F + +P ++F + + TD
Sbjct: 10 GIKNDLKGRLMCYKQDWTGGFKAGFRILAPTTYIFFASAIPVISFGEQLERSTDGVLTAV 69
Query: 113 EVLLSSAIAGLVFGIIGGQPLCIVGVTGPISI---FNYTVYEIIMPLNIDYFGFMFWICI 169
+ L S+AI G++ IIGGQPL I+GV P I F + + L D F+ W+C+
Sbjct: 70 QTLASTAICGMIHSIIGGQPLLILGVAEPTVIMYTFMFNFAKARPELGRDL--FLAWVCV 127
Query: 170 WSMITHFLLVIVNSVCLLQYVTTFPCDIFGLFINVVYIQKGIQILTRQF-VDENSD---- 224
W+ + F+L I + ++ T ++FGL I ++++Q+ I+ L +F + E +
Sbjct: 128 WTALMLFVLAICGACSIINRFTRVAGELFGLLIAMLFMQQAIKGLVDEFRIPERENQKLK 187
Query: 225 -----FNLASGYSSIMVALLMAIFGLAFKFFQLTPLLTYTMRTLISDYSTALSVVFWSGF 279
+ A+G +++++ + + GL + + T +R+LI+DY L V+ W+G
Sbjct: 188 EFLPSWRFANGMFALVLSFGLLLTGLRSRKARSWRYGTGWLRSLIADYGVPLMVLVWTGV 247
Query: 280 IHFGGLLDSVSFQKLPITKAFAPTRHGDSRQTWLAYQDISVGDVFLALPFGIVLTILFYF 339
+ + + + I AF P ++ +L+YF
Sbjct: 248 SYIPAGDEMLDVPIVYIIGAFIPAS---------------------------MIAVLYYF 280
Query: 340 DHNVSSLMAQRKEYKLRKASTFHYDFALLGITTGIAGVLGIPAPNGLIPQAPLHTQSLLV 399
DH+V+S +AQ+KE+ LRK S++HYD LLG T + G+LG+P NG+IPQ+P+HT+SL
Sbjct: 281 DHSVASQLAQQKEFNLRKPSSYHYDLLLLGFLTLMCGLLGVPPSNGVIPQSPMHTKSLAT 340
Query: 400 -----RDDDGNVIRCAEQRFTNTVQGLMILGTMTRPFLICLGLIPQAVLSGLFFIMGIQG 454
DD + EQR +N +Q M+ G + + L +IP +VL G F M I+
Sbjct: 341 LKYQKEIDDLLPVEVKEQRVSNLLQSTMVGGCVAA--MPILKMIPTSVLWGYFAFMAIES 398
Query: 455 LVSNTIVHRIWFVFTDPKKKSK------DSTLNTVSTKSLLLFISLSLVGFVAEFAITNT 508
L N RI +FT P ++ K + + TV K++ +F + F +T
Sbjct: 399 LPGNQFWERILLLFTAPSRRFKVLEDYHATFVETVPFKTIAMFTLFQTTYLLICFGLTWI 458
Query: 509 K-GAIGFPIVLLLTV-ILSLFFPKIFPDKDLAILDEPVSEE 547
+ FP++++ + + P+ F L LD EE
Sbjct: 459 PIAGVMFPLMIMFLIPVRQYLLPRFFKGAHLQDLDAAEYEE 499
>Hs4507021 [P] KOG1172 Na+-independent Cl/HCO3 exchanger AE1 and related
transporters (SLC4 family)
Length = 911
Score = 177 bits (449), Expect = 4e-44
Identities = 126/527 (23%), Positives = 248/527 (46%), Gaps = 36/527 (6%)
Query: 43 EKPRKRFPPLCAGLIHDIKDKVPQYPSDWKDSWDYRVIPSVLETYFNNLLPALAFAQDMF 102
+ P ++ L GL+ DI+ + P Y SD D++ +V+ +V+ YF L PA+ F +
Sbjct: 369 DDPLQQTGQLFGGLVRDIRRRYPYYLSDITDAFSPQVLAAVIFIYFAALSPAITFGGLLG 428
Query: 103 DRTDNSYGVNEVLLSSAIAGLVFGIIGGQPLCIVGVTGPISIFNYTVYEIIMPLNIDYFG 162
++T N GV+E+L+S+A+ G++F ++G QPL +VG +GP+ +F + ++Y
Sbjct: 429 EKTRNQMGVSELLISTAVQGILFALLGAQPLLVVGFSGPLLVFEEAFFSFCETNGLEYIV 488
Query: 163 FMFWICIWSMITHFLLVIVNSVCLLQYVTTFPCDIFGLFINVVYIQKGIQILTRQFVD-- 220
WI W ++ L+V L+++++ + +IF I++++I + L + F D
Sbjct: 489 GRVWIGFWLILLVVLVVAFEGSFLVRFISRYTQEIFSFLISLIFIYETFSKLIKIFQDHP 548
Query: 221 --ENSDFNLAS--------GYSSIMVALLMA---IFGLAFKFFQLTPLLTYTMRTLISDY 267
+ ++N+ ++++ +LMA F + + F+ + +R +I D+
Sbjct: 549 LQKTYNYNVLMVPKPQGPLPNTALLSLVLMAGTFFFAMMLRKFKNSSYFPGKLRRVIGDF 608
Query: 268 STALSVVFWSGFIHFGGLLDSVSFQKLPITKAFAPTRHGDSRQTWLAY-----QDISVGD 322
+S++ + + QKL + F + S + W+ + + +
Sbjct: 609 GVPISILI---MVLVDFFIQDTYTQKLSVPDGFKVS--NSSARGWVIHPLGLRSEFPIWM 663
Query: 323 VFLALPFGIVLTILFYFDHNVSSLMAQRKEYKLRKASTFHYDFALLGITTGIAGVLGIPA 382
+F + +++ IL + + +++L+ + E K+ K S FH D L+ G+A + G+P
Sbjct: 664 MFASALPALLVFILIFLESQITTLIVSKPERKMVKGSGFHLDLLLVVGMGGVAALFGMPW 723
Query: 383 PNGLIPQAPLHTQSLLVRDD------DGNVIRCAEQRFTNTVQGLMI-LGTMTRPFLICL 435
+ ++ H +L V + EQR + + +++ L + P L
Sbjct: 724 LSATTVRSVTHANALTVMGKASTPGAAAQIQEVKEQRISGLLVAVLVGLSILMEPI---L 780
Query: 436 GLIPQAVLSGLFFIMGIQGLVSNTIVHRIWFVFTDPKKKSKDSTLNTVSTKSLLLFISLS 495
IP AVL G+F MG+ L + RI +F PK + V T + LF +
Sbjct: 781 SRIPLAVLFGIFLYMGVTSLSGIQLFDRILLLFKPPKYHPDVPYVKRVKTWRMHLFTGIQ 840
Query: 496 LVGFVAEFAITNTKGAIGFPIVLLLTVIL-SLFFPKIFPDKDLAILD 541
++ + + +T ++ P VL+LTV L + P IF + +L LD
Sbjct: 841 IICLAVLWVVKSTPASLALPFVLILTVPLRRVLLPLIFRNVELQCLD 887
>Hs4827016 [P] KOG1172 Na+-independent Cl/HCO3 exchanger AE1 and related
transporters (SLC4 family)
Length = 1232
Score = 174 bits (442), Expect = 2e-43
Identities = 134/553 (24%), Positives = 252/553 (45%), Gaps = 59/553 (10%)
Query: 43 EKPRKRFPPLCAGLIHDIKDKVPQYPSDWKDSWDYRVIPSVLETYFNNLLPALAFAQDMF 102
+ P R + GL+ D++ + P YPSD +D+ + + +VL YF L PA+ F +
Sbjct: 672 DDPLLRTGSVFGGLVRDVRRRYPHYPSDLRDALHSQCVAAVLFIYFAALSPAITFGGLLG 731
Query: 103 DRTDNSYGVNEVLLSSAIAGLVFGIIGGQPLCIVGVTGPISIFNYTVYEIIMPLNIDYFG 162
++T+ GV+E+++S+A+ G++F ++G QPL +VG +GP+ +F ++ +++Y
Sbjct: 732 EKTEGLMGVSELIVSTAVLGVLFSLLGAQPLLVVGFSGPLLVFEEAFFKFCRAQDLEYLT 791
Query: 163 FMFWICIWSMITHFLLVIVNSVCLLQYVTTFPCDIFGLFINVVYIQKGIQILTRQFVDE- 221
W+ +W ++ LV L++Y++ F +IF I++++I + L + F +
Sbjct: 792 GRVWVGLWLVVFVLALVAAEGSFLVRYISPFTQEIFAFLISLIFIYETFYKLYKVFTEHP 851
Query: 222 ---------NSDFNLASGY----------------------SSIMVALLMAIFGLAF--K 248
+ +LA+G + + + L++ F +AF +
Sbjct: 852 LLPFYPPEGALEGSLAAGLEPNGSALPPTEGPPSPRNQPNTALLSLILMLGTFFIAFFLR 911
Query: 249 FFQLTPLLTYTMRTLISDYSTALSVVFWSGFIHFGGLLDSVSFQKLPITKAFAPTRHGDS 308
F+ + L R +I D+ +S++ + + QKL + + T
Sbjct: 912 KFRNSRFLGGKARRIIGDFGIPISILV---MVLVDYSITDTYTQKLTVPTGLSVT--SPD 966
Query: 309 RQTWLAYQDISVGD------VFLALPFGIVLTILFYFDHNVSSLMAQRKEYKLRKASTFH 362
+++W S V A+P +VL IL + + +++L+ +K +L K S FH
Sbjct: 967 KRSWFIPPLGSARPFPPWMMVAAAVPALLVL-ILIFMETQITALIVSQKARRLLKGSGFH 1025
Query: 363 YDFALLGITTGIAGVLGIPAPNGLIPQAPLHTQSLLVR------DDDGNVIRCAEQRFTN 416
D L+G G+ G+ G+P ++ H +L V D + EQR T
Sbjct: 1026 LDLLLIGSLGGLCGLFGLPWLTAATVRSVTHVNALTVMRTAIAPGDKPQIQEVREQRVT- 1084
Query: 417 TVQGLMILGTMTRPFLI--CLGLIPQAVLSGLFFIMGIQGLVSNTIVHRIWFVFTDPKKK 474
G++I + ++ L IP AVL G+F MG+ L + R+ + K
Sbjct: 1085 ---GVLIASLVGLSIVMGAVLRRIPLAVLFGIFLYMGVTSLSGIQLSQRLLLILMPAKHH 1141
Query: 475 SKDSTLNTVSTKSLLLFISLSLVGFVAEFAITNTKGAIGFPIVLLLTVIL-SLFFPKIFP 533
+ + V T + LF + L + + +T ++ FP +LLLTV L P++F
Sbjct: 1142 PEQPYVTKVKTWRMHLFTCIQLGCIALLWVVKSTAASLAFPFLLLLTVPLRHCLLPRLFQ 1201
Query: 534 DKDLAILDEPVSE 546
D++L LD +E
Sbjct: 1202 DRELQALDSEDAE 1214
>Hs21361551 [P] KOG1172 Na+-independent Cl/HCO3 exchanger AE1 and related
transporters (SLC4 family)
Length = 1241
Score = 174 bits (440), Expect = 4e-43
Identities = 138/566 (24%), Positives = 254/566 (44%), Gaps = 71/566 (12%)
Query: 43 EKPRKRFPPLCAGLIHDIKDKVPQYPSDWKDSWDYRVIPSVLETYFNNLLPALAFAQDMF 102
+ P +R GLI D++ + P Y SD++D+ D + + +V+ YF L PA+ F +
Sbjct: 672 DDPLRRTGRPFGGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAALSPAITFGGLLG 731
Query: 103 DRTDNSYGVNEVLLSSAIAGLVFGIIGGQPLCIVGVTGPISIFNYTVYEIIMPLNIDYFG 162
++T + GV+E+++S+A+ G+VF ++G QPL ++G +GP+ +F + +++Y
Sbjct: 732 EKTQDLIGVSELIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEAFFSFCSSNHLEYLV 791
Query: 163 FMFWICIWSMITHFLLVIVNSVCLLQYVTTFPCDIFGLFINVVYIQKGIQILTRQF---- 218
WI W + L+V + L+++V+ F +IF I++++I + L + F
Sbjct: 792 GRVWIGFWLVFLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETFYKLVKIFQEHP 851
Query: 219 -----------VDENSDFNLA-------------SGYSS------------IMVALLMAI 242
VD + A +G S + + L+
Sbjct: 852 LHGCSASNSSEVDGGENMTWAGARPTLGPGNRSLAGQSGQGKPRGQPNTALLSLVLMAGT 911
Query: 243 FGLAF--KFFQLTPLLTYTMRTLISDYSTALSVVFWSGFIHFGGLLDSVSFQKLPITKAF 300
F +AF + F+ + +R +I D+ ++++ + ++ QKL + F
Sbjct: 912 FFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILI---MVLVDYSIEDTYTQKLSVPSGF 968
Query: 301 ---APTRHGDSRQTWLAYQDISVGDVFLALPFGIVLTILFYFDHNVSSLMAQRKEYKLRK 357
AP + G V + +L I++ IL + + +++L+ +KE L+K
Sbjct: 969 SVTAPEKRGWVINPLGEKSPFPVWMMVASLLPAILVFILIFMETQITTLIISKKERMLQK 1028
Query: 358 ASTFHYDFALLGITTGIAGVLGIPAPNGLIPQAPLHTQSLLVRD------DDGNVIRCAE 411
S FH D L+ GI + G+P ++ H +L V D + E
Sbjct: 1029 GSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANALTVMSKAVAPGDKPKIQEVKE 1088
Query: 412 QRFTNTVQGLM-----ILGTMTRPFLICLGLIPQAVLSGLFFIMGIQGLVSNTIVHRIWF 466
QR T + L+ ++G + R IP AVL G+F MG+ L R+
Sbjct: 1089 QRVTGLLVALLVGLSIVIGDLLRQ-------IPLAVLFGIFLYMGVTSLNGIQFYERLHL 1141
Query: 467 VFTDPKKKSKDSTLNTVSTKSLLLFISLSLVGFVAEFAITNTKGAIGFPIVLLLTVILSL 526
+ PK + + V T + LF +L L+ +A+ +T ++ FP +L+LTV L +
Sbjct: 1142 LLMPPKHHPDVTYVKKVRTLRMHLFTALQLLCLALLWAVMSTAASLAFPFILILTVPLRM 1201
Query: 527 -FFPKIFPDKDLAILD----EPVSEE 547
+IF D+++ LD EPV +E
Sbjct: 1202 VVLTRIFTDREMKCLDANEAEPVFDE 1227
>HsM4507023 [P] KOG1172 Na+-independent Cl/HCO3 exchanger AE1 and related
transporters (SLC4 family)
Length = 1240
Score = 173 bits (438), Expect = 7e-43
Identities = 136/554 (24%), Positives = 250/554 (44%), Gaps = 71/554 (12%)
Query: 55 GLIHDIKDKVPQYPSDWKDSWDYRVIPSVLETYFNNLLPALAFAQDMFDRTDNSYGVNEV 114
GLI D++ + P Y SD++D+ D + + +V+ YF L PA+ F + ++T + GV+E+
Sbjct: 683 GLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAALSPAITFGGLLGEKTQDLIGVSEL 742
Query: 115 LLSSAIAGLVFGIIGGQPLCIVGVTGPISIFNYTVYEIIMPLNIDYFGFMFWICIWSMIT 174
++S+A+ G+VF ++G QPL ++G +GP+ +F + +++Y WI W +
Sbjct: 743 IMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEAFFSFCSSNHLEYLVGRVWIGFWLVFL 802
Query: 175 HFLLVIVNSVCLLQYVTTFPCDIFGLFINVVYIQKGIQILTRQF---------------V 219
L+V + L+++V+ F +IF I++++I + L + F V
Sbjct: 803 ALLMVALEGSFLVRFVSRFTREIFAFLISLIFIYETFYKLVKIFQEHPLHGCSASNSSEV 862
Query: 220 DENSDFNLA-------------SGYSS------------IMVALLMAIFGLAF--KFFQL 252
D + A +G S + + L+ F +AF + F+
Sbjct: 863 DGGENMTWAGARPTLGPGNRSLAGQSGQGKPRGQPNTAPLSLVLMAGTFFIAFFLRKFKN 922
Query: 253 TPLLTYTMRTLISDYSTALSVVFWSGFIHFGGLLDSVSFQKLPITKAF---APTRHGDSR 309
+ +R +I D+ ++++ + ++ QKL + F AP + G
Sbjct: 923 SRFFPGRIRRVIGDFGVPIAILI---MVLVDYSIEDTYTQKLSVPSGFSVTAPEKRGWVI 979
Query: 310 QTWLAYQDISVGDVFLALPFGIVLTILFYFDHNVSSLMAQRKEYKLRKASTFHYDFALLG 369
V + +L I++ IL + + +++L+ +KE L+K S FH D L+
Sbjct: 980 NPLGEKSPFPVWMMVASLLPAILVFILIFMETQITTLIISKKERMLQKGSGFHLDLLLIV 1039
Query: 370 ITTGIAGVLGIPAPNGLIPQAPLHTQSLLVRD------DDGNVIRCAEQRFTNTVQGLM- 422
GI + G+P ++ H +L V D + EQR T + L+
Sbjct: 1040 AMGGICALFGLPWLAAATVRSVTHANALTVMSKAVAPGDKPKIQEVKEQRVTGLLVALLV 1099
Query: 423 ----ILGTMTRPFLICLGLIPQAVLSGLFFIMGIQGLVSNTIVHRIWFVFTDPKKKSKDS 478
++G + R IP AVL G+F MG+ L R+ + PK +
Sbjct: 1100 GLSIVIGDLLRQ-------IPLAVLFGIFLYMGVTSLNGIQFYERLHLLLMPPKHHPDVT 1152
Query: 479 TLNTVSTKSLLLFISLSLVGFVAEFAITNTKGAIGFPIVLLLTVILSL-FFPKIFPDKDL 537
+ V T + LF +L L+ +A+ +T ++ FP +L+LTV L + +IF D+++
Sbjct: 1153 YVKKVRTLRMHLFTALQLLCLALLWAVMSTAASLAFPFILILTVPLRMVVLTRIFTDREM 1212
Query: 538 AILD----EPVSEE 547
LD EPV +E
Sbjct: 1213 KCLDANEAEPVFDE 1226
>At1g15460 [P] KOG1172 Na+-independent Cl/HCO3 exchanger AE1 and related
transporters (SLC4 family)
Length = 683
Score = 173 bits (438), Expect = 7e-43
Identities = 108/373 (28%), Positives = 196/373 (51%), Gaps = 34/373 (9%)
Query: 52 LCAGLIHDIKDKVPQYPSDWKDSW--DYRVIPSVLETYFNNLLPALAFAQDMFDRTDNSY 109
L G++ D++ + Y DW + ++ +F + LP +AF + + T+ +
Sbjct: 12 LFRGIVADLRGRALCYKEDWVAGLRSGFGILAPTTYIFFASALPVIAFGEQLSRDTEGAL 71
Query: 110 GVNEVLLSSAIAGLVFGIIGGQPLCIVGVTGP-----ISIFNYTVYEIIMPLNIDYFGFM 164
E L S+A+ G++ I+GGQPL I+GV P + ++N+ + + + Y +
Sbjct: 72 STVETLASTALCGVIHSILGGQPLLILGVAEPTVLMYVYLYNFAIGRPELGKQL-YLAWA 130
Query: 165 FWICIWSMITHFLLVIVNSVCLLQYVTTFPCDIFGLFINVVYIQKGIQILTRQF---VDE 221
W+C+W+ + F++ I+N+ ++ T ++FG+ I+V++IQ+ I+ + +F DE
Sbjct: 131 AWVCVWTALLLFVMAILNTADIINRFTRVAGELFGMLISVLFIQQAIKGMVSEFGMPKDE 190
Query: 222 NSD---FNLASGYSSIMVALLMAIFGLAFKFFQLTPLLTYTM-----RTLISDYSTALSV 273
+S + Y++ ++ L+ FGL + + ++ R+ I+DY L V
Sbjct: 191 DSKLEKYKFEWLYTNGLLGLIFT-FGLLYTALKSRKARSWRYGTGWYRSFIADYGVPLMV 249
Query: 274 VFWSGFIHFGGLLDSVSFQKLPI---TKAFAPTR-HGDSRQTWLAYQD---ISVGDVFLA 326
V W+ L + KLP + F+P S W +D +S G +F A
Sbjct: 250 VVWTA-------LSFSTPSKLPSGVPRRLFSPLPWDSPSLSHWTVIKDMGKVSPGYIFAA 302
Query: 327 LPFGIVLTILFYFDHNVSSLMAQRKEYKLRKASTFHYDFALLGITTGIAGVLGIPAPNGL 386
+++ L++FDH+V+S +AQ+KE+ L+K S +HYD LLG T I G+LG+P NG+
Sbjct: 303 FIPALMIAGLYFFDHSVASQLAQQKEFNLKKPSAYHYDILLLGFMTLICGLLGLPPSNGV 362
Query: 387 IPQAPLHTQSLLV 399
+PQ+P+HT+SL V
Sbjct: 363 LPQSPMHTKSLAV 375
Score = 50.8 bits (120), Expect = 5e-06
Identities = 44/149 (29%), Positives = 65/149 (43%), Gaps = 10/149 (6%)
Query: 407 IRCAEQRFTNTVQGLMILGTMTRPFLICLGLIPQAVLSGLFFIMGIQGLVSNTIVHRIWF 466
+R EQR +N +Q L++ G + + + LIP ++L G F M I L N R+
Sbjct: 464 VRVNEQRVSNLLQSLLVAGAVLA--MPAIKLIPTSILWGYFAYMAIDSLPGNQFFERLTL 521
Query: 467 VFTDPKKKSK------DSTLNTVSTKSLLLFISLSLVGFVAEFAITNTKGA-IGFPI-VL 518
+F ++ K S + V KS+ F L + F + +T A I FP+
Sbjct: 522 LFVPTSRRFKVLEGAHASFVEKVPYKSMAAFTLLQIFYFGLCYGVTWIPVAGIMFPVPFF 581
Query: 519 LLTVILSLFFPKIFPDKDLAILDEPVSEE 547
LL I PK+F L LD EE
Sbjct: 582 LLIAIRQYILPKLFNPAHLRELDAAEYEE 610
>At3g62270 [P] KOG1172 Na+-independent Cl/HCO3 exchanger AE1 and related
transporters (SLC4 family)
Length = 703
Score = 170 bits (431), Expect = 5e-42
Identities = 106/365 (29%), Positives = 195/365 (53%), Gaps = 28/365 (7%)
Query: 55 GLIHDIKDKVPQYPSDWKDSWD--YRVIPSVLETYFNNLLPALAFAQDMFDRTDNSYGVN 112
G+ +D+K ++ Y DW +R++ +F + +P ++F + + TD
Sbjct: 10 GIKNDLKGRLMCYKQDWTGGIKAGFRILAPTTYIFFASAIPVISFGEQLERSTDGVLTAV 69
Query: 113 EVLLSSAIAGLVFGIIGGQPLCIVGVTGPISI-----FNYTVYEIIMPLNIDYFGFMFWI 167
+ L S+AI G++ IIGGQPL I+GV P I FN+ + N+ + + W+
Sbjct: 70 QTLASTAICGIIHSIIGGQPLLILGVAEPTVIMYTFMFNFAKGRPELGRNL-FLAWSGWV 128
Query: 168 CIWSMITHFLLVIVNSVCLLQYVTTFPCDIFGLFINVVYIQKGIQILTRQF--------- 218
C+W+ + F+L I + + T ++FGL I ++++Q+ I+ L +F
Sbjct: 129 CVWTSLILFVLAICGACSFINRFTRVAGELFGLLIAMLFMQQAIKGLVDEFRAPAREDLK 188
Query: 219 -VDENSDFNLASGYSSIMVALLMAIFGLAFKFFQLTPLLTYTMRTLISDYSTALSVVFWS 277
V+ + A+G +++++ + I L + + T +R+L++DY L V+ W+
Sbjct: 189 LVEFLPSWRFANGMFALVLSFGLLITALRSRKARSWRYGTGWLRSLVADYGVPLMVLVWT 248
Query: 278 G--FIHFGGLLDSVSFQKLPITKAFAPTRHGDSRQTWLAYQD-ISVGDVFLALPF--GIV 332
G +I G + + ++L ++P + + W ++ + V V++ F +
Sbjct: 249 GVSYIPTGDVPKGIP-RRLFSPNPWSPGAY----ENWTVVKEMLQVPIVYIIGAFIPATM 303
Query: 333 LTILFYFDHNVSSLMAQRKEYKLRKASTFHYDFALLGITTGIAGVLGIPAPNGLIPQAPL 392
+ +L+YFDH+V+S +AQ+KE+ LRK S++HYD LLG T + G+LGIP NG+IPQ+P+
Sbjct: 304 IAVLYYFDHSVASQLAQQKEFNLRKPSSYHYDLLLLGFLTLMCGLLGIPPSNGVIPQSPM 363
Query: 393 HTQSL 397
HT+SL
Sbjct: 364 HTKSL 368
Score = 52.4 bits (124), Expect = 2e-06
Identities = 43/154 (27%), Positives = 69/154 (43%), Gaps = 10/154 (6%)
Query: 402 DDGNVIRCAEQRFTNTVQGLMILGTMTRPFLICLGLIPQAVLSGLFFIMGIQGLVSNTIV 461
DD I EQR +N +Q +M+ G + L L +IP +VL G F M I+ L N
Sbjct: 453 DDLLPIEVKEQRVSNLLQAVMVGGCVAAMPL--LKMIPTSVLWGYFAFMAIESLPGNQFW 510
Query: 462 HRIWFVFTDPKKKSK------DSTLNTVSTKSLLLFISLSLVGFVAEFAITNTK-GAIGF 514
RI +FT P ++ K + + TV K++ +F + F +T + F
Sbjct: 511 ERILLLFTAPSRRFKVLEDNHATFVETVPFKTIAMFTIFQTTYLLTCFGLTWIPIAGVMF 570
Query: 515 PIVLLLTV-ILSLFFPKIFPDKDLAILDEPVSEE 547
P++++ + + P+ F L LD EE
Sbjct: 571 PLLIMFLIPVRQYILPRFFKSAHLQDLDAAEYEE 604
>At4g32510 [P] KOG1172 Na+-independent Cl/HCO3 exchanger AE1 and related
transporters (SLC4 family)
Length = 710
Score = 166 bits (419), Expect = 1e-40
Identities = 112/386 (29%), Positives = 197/386 (51%), Gaps = 49/386 (12%)
Query: 55 GLIHDIKDKVPQYPSDWKDSWD-----------YRVIPSVLETYFNNLLPALAFAQDMFD 103
G+I+D + Y DW +++ + ++ L + + LP +AF + +
Sbjct: 10 GIINDFNGRRKCYKQDWLAAFNSGVRYYTLFMLFSILAPTLYIFIASALPVIAFGEQLSR 69
Query: 104 RTDNSY-GVNEVLLSSAIAGLVFGIIGGQPLCIVGVTGPISIFNYTVYEIIMPLNID--- 159
T + Y G+ E L S+A+ G++ + GGQPL IVGV P +I YT +
Sbjct: 70 ETGDRYLGIAESLASTALCGIIHSVFGGQPLLIVGVAEP-TIIMYTYLHSFSKSRPELGQ 128
Query: 160 --YFGFMFWICIWSMITHFLLVIVNSVCLLQYVTTFPCDIFGLFINVVYIQKGIQI---- 213
Y + W+C+W+ + LL ++N+ ++ T ++FG+ I V++IQ+ +++
Sbjct: 129 KLYLAWAGWVCVWTAVLLMLLAMLNACNIISRFTRIAGELFGMLITVLFIQEAVKVVMGI 188
Query: 214 ---LTRQFVDENSD------FNLASGYSSIMVALLMAIFGLAFKFFQLTPLLTYT----- 259
L +F+ SD + Y++ ++A++ + FGL + + ++
Sbjct: 189 YMGLIGEFLVPKSDDPSLEVYQFQWRYTNGLLAVIFS-FGLLYTALKSRRARSWKYGFRW 247
Query: 260 MRTLISDYSTALSVVFWSGFIHF--GGLLDSVSFQ-KLPITKAFAPTRHGDSRQTWLAYQ 316
MR I DY T L +V WS F + L + V + +LP+ A H W +
Sbjct: 248 MRGFIGDYGTLLMLVLWSAFSYTVPRNLPEGVPRRLELPLPWASESLYH------WTVVK 301
Query: 317 DIS-VGDVFLALPF--GIVLTILFYFDHNVSSLMAQRKEYKLRKASTFHYDFALLGITTG 373
D++ V +++ F I++ L++FDH VS+ MAQ+KE+ L+ + +HYD +LGI T
Sbjct: 302 DMAKVPPLYILAAFIPAIMIAGLYFFDHCVSAQMAQQKEFNLKNPTAYHYDIFILGIMTL 361
Query: 374 IAGVLGIPAPNGLIPQAPLHTQSLLV 399
I G+LG+P NG+IPQ+P+HT+SL V
Sbjct: 362 ICGLLGLPPSNGVIPQSPMHTKSLAV 387
Score = 50.8 bits (120), Expect = 5e-06
Identities = 45/161 (27%), Positives = 72/161 (43%), Gaps = 18/161 (11%)
Query: 399 VRDDDGNVIRCAEQRFTNTVQ----GLMILGTMTRPFLICLGLIPQAVLSGLFFIMGIQG 454
V +D +R EQR +N +Q GL+IL L +IP +VL G F M +
Sbjct: 484 VHIEDHLPVRVNEQRVSNLLQSVLVGLLILAVPV------LRMIPTSVLWGYFTYMAVDS 537
Query: 455 LVSNTIVHRIWFVFTDPKKKSK------DSTLNTVSTKSLLLFISLSLVGFVAEFAIT-N 507
L N R+ +F P ++ K S + V KS+++F L+ F+ + +T
Sbjct: 538 LPGNQFWERLQLLFITPGRRFKVLEGLHASFVEIVPYKSIVMFTLFQLLYFLICYGVTWI 597
Query: 508 TKGAIGFPIVLLLTVILSLF-FPKIFPDKDLAILDEPVSEE 547
G I FP+ + + L + ++F L +LD EE
Sbjct: 598 PVGGILFPLPFFILIALRQYILQRLFDPSHLQVLDSSEYEE 638
>7297232 [P] KOG1172 Na+-independent Cl/HCO3 exchanger AE1 and related
transporters (SLC4 family)
Length = 1086
Score = 164 bits (416), Expect = 2e-40
Identities = 142/550 (25%), Positives = 241/550 (43%), Gaps = 65/550 (11%)
Query: 52 LCAGLIHDIKDKVPQYPSDWKDSWDYRVIPSVLETYFNNLLPALAFAQDMFDRTDNSYGV 111
L GLI+DIK K P Y SD+KD+ + + S + YF L P + F + + T
Sbjct: 469 LFGGLINDIKRKAPWYISDYKDALSMQCVASWIFLYFACLSPIITFGGLLAEATGKHMAA 528
Query: 112 NEVLLSSAIAGLVFGIIGGQPLCIVGVTGPISIFNYTVYEIIMPLNIDYFGFMFWICIWS 171
E L+S + G+ +G GQPL I+G TGP+ +F +YE + + DY F FWI +W
Sbjct: 529 MESLVSGFVCGMGYGFFSGQPLTILGSTGPVLVFESIIYEFCLKMGWDYMTFRFWIGMWV 588
Query: 172 MITHFLLVIVNSVCLLQYVTTFPCDIFGLFINVVYIQKGIQ---ILTRQF---------- 218
+L +++ L+ Y+T F + F I ++I K I+ ++ + F
Sbjct: 589 AGICIVLTAIDASALVCYITRFTEENFATLIAFIFIYKAIENVMVIGKNFPVNQGIYDCV 648
Query: 219 ----VDENS--------DFNLASGYSSIMV-----------ALLMAIFGLAFKFFQLTPL 255
+ N+ +++ Y+ +V LM++ A F T L
Sbjct: 649 CTPPIGSNASVIDYAKYNWDSCESYNGTLVGGDCGTPPTENVFLMSVVLCAGTFLISTVL 708
Query: 256 LTY--------TMRTLISDYSTALSVVFWSGFIHFGGLLDSVSFQKLPITKAFAPTRHGD 307
+ +R ISD+S +++ S F + G V QKL + PT
Sbjct: 709 KEFKNALFFPSIVRQYISDFSVLIAIFAMSFFDYSLG----VPTQKLEVPNELKPTL--- 761
Query: 308 SRQTWLAYQDISVG---DVFLALPFGIVLTILFYFDHNVSSLMAQRKEYKLRKASTFHYD 364
S + WL + +A+ ++ TIL + D +++++ RKE KL+K +H D
Sbjct: 762 STRGWLIPPFVEKNPWWSAIIAVFPALLGTILIFMDQQITAVIVNRKENKLKKGCGYHLD 821
Query: 365 FALLGITTGIAGVLGIPAPNGLIPQAPLHTQSLLVRD------DDGNVIRCAEQRFTNTV 418
+L I I ++G+P + H SL + + + EQR T+ +
Sbjct: 822 LFILSILIAICSMMGLPWFVAATVLSINHVNSLKLESECSAPGEKPQFLGVREQRVTHIL 881
Query: 419 QGLMI-LGTMTRPFLICLGLIPQAVLSGLFFIMGIQGLVSNTIVHRIWFVFTDPKKKSKD 477
L I + + P LG IP VL G+F MG+ L RI +F K +
Sbjct: 882 IFLTIGVSVLLTPL---LGNIPMPVLFGVFLYMGVASLKGLQFFDRILIMFMPAKYQPDY 938
Query: 478 STLNTVSTKSLLLFISLSLVGFVAEFAITN-TKGAIGFPIVLLLTVILSLFFPKIFPDKD 536
L V K + LF + L + + I + ++ +I FP++L++ + + +F ++
Sbjct: 939 MFLRQVPIKRVHLFTMIQLACLIILWLIKSFSQTSILFPLMLVVMIGIRKALDLVFTRRE 998
Query: 537 LAILDEPVSE 546
L ILD+ + E
Sbjct: 999 LKILDDIMPE 1008
>At3g06450 [P] KOG1172 Na+-independent Cl/HCO3 exchanger AE1 and related
transporters (SLC4 family)
Length = 736
Score = 158 bits (400), Expect = 2e-38
Identities = 99/370 (26%), Positives = 191/370 (50%), Gaps = 34/370 (9%)
Query: 55 GLIHDIKDKVPQYPSDWKDSW--DYRVIPSVLETYFNNLLPALAFAQDMFDRTDNSYGVN 112
G+ D+K ++ Y DW +R++ +F + +P + F + + TD
Sbjct: 12 GIKKDVKGRLNCYKQDWISGLRAGFRILAPTTYIFFASAIPVITFGEQLERDTDGKITAV 71
Query: 113 EVLLSSAIAGLVFGIIGGQPLCIVGVTGPISI-----FNYTVYEIIMPLNIDYFGFMFWI 167
+ L+S+A+ G++ IIGGQPL I+GV P I FN+ + N+ + + W+
Sbjct: 72 QTLVSTALCGVIHSIIGGQPLLILGVAEPTVIMYTFMFNFAKSRTDLGSNL-FLAWTGWV 130
Query: 168 CIWSMITHFLLVIVNSVCLLQYVTTFPCDIFGLFINVVYIQKGIQILTRQFV------DE 221
C+W+ + FLL ++ + + T ++FG+ I ++++Q+ I+ + +F
Sbjct: 131 CLWTGLLLFLLAVLGACTFINRFTRLAGELFGILIAMLFMQEAIRGIVDEFGVPGRTNPR 190
Query: 222 NSDFNLASGYSSIMVALLMAIFGLAFKFFQLTPLLTYT-----MRTLISDYSTALSVVFW 276
+++F A +++ M L+++ GL + + ++ +R I+DY + VV W
Sbjct: 191 SAEFQPAWVFANGMFGLVLSS-GLLYTGLKSRKARSWRFGAEWLRGFIADYGVPVMVVVW 249
Query: 277 S--GFIHFGGLLDSVSFQKLPITKAFAPTRHGDSRQTWLAYQ-------DISVGDVFLAL 327
+ +I + + + ++L ++P + Q W D+ V + LA+
Sbjct: 250 TCISYIPWKSVPQGIP-RRLVSPNPWSPGAY----QNWTCMMNKLQEMVDVPVLYILLAV 304
Query: 328 PFGIVLTILFYFDHNVSSLMAQRKEYKLRKASTFHYDFALLGITTGIAGVLGIPAPNGLI 387
++ +L+YFDH+V+S +AQ++++ LRK +HYD LLG T + G++GIP NG+I
Sbjct: 305 VPASMIAVLYYFDHSVASQLAQQEDFNLRKPPAYHYDLFLLGFLTILCGLIGIPPSNGVI 364
Query: 388 PQAPLHTQSL 397
PQ+P+HT+SL
Sbjct: 365 PQSPMHTKSL 374
>At1g74810 [P] KOG1172 Na+-independent Cl/HCO3 exchanger AE1 and related
transporters (SLC4 family)
Length = 668
Score = 156 bits (394), Expect = 9e-38
Identities = 98/335 (29%), Positives = 171/335 (50%), Gaps = 30/335 (8%)
Query: 87 YFNNLLPALAFAQDMFDRTDNSYGVNEVLLSSAIAGLVFGIIGGQPLCIVGVTGPISIFN 146
+F + LP +AF + + T+ S E L S+A+ G++ ++GGQPL I+GV P +
Sbjct: 34 FFASALPVIAFGEQLSHDTERSLSTVETLASTALCGVIHSLLGGQPLLILGVAEPTVLMY 93
Query: 147 YTVYEIIMPL----NIDYFGFMFWICIWSMITHFLLVIVNSVCLLQYVTTFPCDIFGLFI 202
+Y+ Y ++ W+C+W+ + FL+ I N ++ T ++FG+ I
Sbjct: 94 KYLYDFAKGRPELGKQLYLAWVAWVCVWTALLLFLMAIFNMAYIINRFTRIAGELFGMLI 153
Query: 203 NVVYIQKGIQILTRQF-VDENSDFNLASG-----YSSIMVALLMAIFGLAFKFFQLT--- 253
V+++Q+ I+ + +F + + D L Y++ ++ L+ + GL + +
Sbjct: 154 AVLFLQQTIKGMVSEFRIPKGEDSKLEKYQFEWLYTNGLLGLIFTV-GLVYTALKSRKAR 212
Query: 254 --PLLTYTMRTLISDYSTALSVVFWSGFIHFGGLLDSVSFQKLP--ITKAFAPTRHGDSR 309
P T R+ ++DY L VV W+ L + KLP + + DS
Sbjct: 213 SWPYGTGCCRSFVADYGVPLMVVVWTA-------LSFSTPSKLPSGVPRRLVSPLPWDSV 265
Query: 310 QT--WLAYQD---ISVGDVFLALPFGIVLTILFYFDHNVSSLMAQRKEYKLRKASTFHYD 364
W +D +S G +F A +++ L++FDH+V S +AQ+KE+ L+ S +HYD
Sbjct: 266 SLTHWTVIKDMGKVSPGYIFAAFIPALMIAGLYFFDHSVVSQLAQQKEFNLKNPSAYHYD 325
Query: 365 FALLGITTGIAGVLGIPAPNGLIPQAPLHTQSLLV 399
LLG I G+LG+P NG++PQ+P+HT+SL V
Sbjct: 326 ILLLGFMVLICGMLGLPPSNGVLPQSPMHTKSLAV 360
Score = 52.4 bits (124), Expect = 2e-06
Identities = 45/149 (30%), Positives = 67/149 (44%), Gaps = 10/149 (6%)
Query: 407 IRCAEQRFTNTVQGLMILGTMTRPFLICLGLIPQAVLSGLFFIMGIQGLVSNTIVHRIWF 466
+R EQR +N +Q L+++G + L + LIP ++L G F M I L N R
Sbjct: 449 VRVNEQRVSNLLQSLLVIGAVFA--LPVIKLIPTSLLWGYFAYMAIDSLPDNQFFERTVL 506
Query: 467 VFTDPKKKSK------DSTLNTVSTKSLLLFISLSLVGFVAEFAITNTKGA-IGFPIV-L 518
+F P ++ K S + V KS+ F ++ F + +T A I FP++
Sbjct: 507 LFVPPTRRFKVLEGAHASFVEKVPHKSIAAFTLFQILYFGLCYGVTWIPVAGIMFPVLFF 566
Query: 519 LLTVILSLFFPKIFPDKDLAILDEPVSEE 547
LL I PK+F L LD EE
Sbjct: 567 LLVAIRQYLLPKLFKPAYLRELDAAEYEE 595
>At5g25430 [P] KOG1172 Na+-independent Cl/HCO3 exchanger AE1 and related
transporters (SLC4 family)
Length = 641
Score = 149 bits (376), Expect = 1e-35
Identities = 102/317 (32%), Positives = 163/317 (51%), Gaps = 28/317 (8%)
Query: 104 RTDNSYGVNEVLLSSAIAGLVFGIIGGQPLCIVGVTGP-ISIFNYTVYEIIMPLNID--- 159
+T + E L S++I G++ I GGQPL IVGV P I ++ Y I +I
Sbjct: 33 KTGGALSAVETLASTSICGIIHAIFGGQPLLIVGVAEPTIIMYTYLYSFCISRPDIGREL 92
Query: 160 YFGFMFWICIWSMITHFLLVIVNSVCLLQYVTTFPCDIFGLFINVVYIQKGIQILTRQFV 219
Y ++ W+C+W+ + LL I N+ ++ T ++FG+ I V+++Q+ I+ L +F
Sbjct: 93 YLAWVAWVCVWTSVLLILLSIFNAGTIITRFTRIAGELFGMLIAVLFLQEAIKGLISEFH 152
Query: 220 DENSDFNLASGYSSIMV----ALLMAIFGLAFKFFQLTPLLTYT-------MRTLISDYS 268
N +G S ++ LL IF L L + +R+ I DY
Sbjct: 153 APEIK-NQETGKSHFLLIYANGLLAVIFSLGLLITALKSRRAKSWKYGFGWLRSFIGDYG 211
Query: 269 TALSVVFWSGFIHFGGLLDSVSFQKLPIT--KAFAPTR-HGDSRQTWLAYQDIS-VGDVF 324
L V+ W+ + +V + LP + F P S W +D+ V ++
Sbjct: 212 VPLMVLLWTALSY------TVPSEVLPSVPRRLFCPLPWEPASLYHWTVVKDMGKVPIMY 265
Query: 325 LALPF--GIVLTILFYFDHNVSSLMAQRKEYKLRKASTFHYDFALLGITTGIAGVLGIPA 382
+ F G+++ L++FDH+V+S MAQ+KE+ L+ S +HYD LLGI T I G+LG+P
Sbjct: 266 ILAAFIPGVMIAGLYFFDHSVASQMAQQKEFNLKNPSAYHYDIFLLGIITLICGLLGLPP 325
Query: 383 PNGLIPQAPLHTQSLLV 399
NG++PQAP+HT+SL V
Sbjct: 326 SNGVLPQAPMHTKSLAV 342
>CE28476 [P] KOG1172 Na+-independent Cl/HCO3 exchanger AE1 and related
transporters (SLC4 family)
Length = 959
Score = 145 bits (367), Expect = 1e-34
Identities = 145/603 (24%), Positives = 252/603 (41%), Gaps = 98/603 (16%)
Query: 18 EHFRITNLDIASQKSKD--------SDVEI----QSIEKPRKRFPPLCAGLIHDIKDKVP 65
E FR T L A + + D S + + + I P +P GL+ + K ++
Sbjct: 373 EQFRSTLLSAAKELAMDQNQWRERKSSIHLSHAKEQIFGPEAWYP--FRGLVEEFKRRLA 430
Query: 66 QYPSDWKDSWD-----YRVIPSVLETYFNNLLPALAFAQDMFDRTDNSYGVNEVLLSSAI 120
YPSD+ D ++ +V+ YF LLPA+AF D T + V +V+++ AI
Sbjct: 431 IYPSDYLDGIRGHKTVQKLFSTVVFLYFACLLPAIAFGVLNDDNTKGAINVRKVIIAQAI 490
Query: 121 AGLVFGIIGGQPLCIVGVTGPISIFNYTVYEIIMPLNIDYFGFMFWICIWSMITHFLLVI 180
G+ F + GGQP+ I+ T P++I+ +++I L D+ + C+ FL++
Sbjct: 491 GGIFFSLFGGQPMIILLTTVPLAIYIKVIFKISQELGYDFLAM--YACVGLFCQMFLILY 548
Query: 181 -VNSVC-LLQYVTTFPCDIFGLFINVVYIQKGIQILTRQFVDENSDF------------- 225
+C L+++ T ++F LFI + + + I+ + F +D
Sbjct: 549 SATELCSLMKFATRSAEEMFSLFIAIAFTVESIRAIHNSFKKNYNDCDTSAISMKAARTA 608
Query: 226 ---------------NLASGYS------------SIMVALLM---AIFGLAFKFFQLTPL 255
N+ S S SI+ LLM GL F+ TP
Sbjct: 609 LNAFKNGSNADSIVGNITSSMSIGDTGSLCRRDTSILYMLLMFGTLWLGLFLYNFRKTPY 668
Query: 256 LTYTMRTLISDYSTALSVVFWSGFIHFGG--LLDSVSFQKLPITKAFAPTRHGDSRQTWL 313
LT + R ++DY+ SV+ S F G + + + F + D
Sbjct: 669 LTRSRREWLADYALPASVLIMS----FTGSYAFSDIEKDRFNLRFEFPLIQMAD------ 718
Query: 314 AYQDISVGDVFLALPFGIVLTILFYFDHNVSSLMAQRKEYKLRKASTFHYDFALLGITTG 373
+ F+ L G L+ LF+ D N++S + + KL+K ++ + D ++ +
Sbjct: 719 -VTSLPPSGYFVCLLLGFSLSFLFFIDQNITSAIVNNNQNKLKKGTSHNLDLFVVALLNM 777
Query: 374 IAGVLGIPAPNGLIPQAPLHTQSLL---VRDDDGNV----IRCAEQRFTNTVQGLMILGT 426
V G+P +G +P +PLH ++L R G+V + E R + + +MIL +
Sbjct: 778 FLSVFGLPWMHGALPHSPLHLRALADVEERVSQGHVHEVIMNVRETRLASLIAHVMILVS 837
Query: 427 MTRPFLICLGLIPQAVLSGLFFIMGIQGLVSNTIVHRIWFVFTDPKKKSKDSTLNTVSTK 486
M L LIP +VL GLF M + L N + R+ + T+ + + V +
Sbjct: 838 MFFLIPYPLQLIPTSVLHGLFLYMALTSLSGNEMFERLLLLITEQQAYPPTHYIRKVPQR 897
Query: 487 SLLLFISLSLVGFVAEFAITNTKGAIGFPIVLLLTVILSLFF--------PKIFPDKDLA 538
+ LF + L+ + A G +P + ++ I+ FF P++ K L
Sbjct: 898 KVHLFTACQLLQLIILCAF----GFSPYPFIEMVFPIVCFFFLPIRHTLIPRLIDYKYLD 953
Query: 539 ILD 541
LD
Sbjct: 954 ALD 956
>7294876 [P] KOG1172 Na+-independent Cl/HCO3 exchanger AE1 and related
transporters (SLC4 family)
Length = 1239
Score = 142 bits (357), Expect = 2e-33
Identities = 124/571 (21%), Positives = 242/571 (41%), Gaps = 69/571 (12%)
Query: 32 SKDSDVEIQSIEKPRKRFPPLCAGLIHDIKDKVPQYPSDWKDSWDYRVIPSVLETYFNNL 91
S D + + P ++ L GL +D+K ++P Y SD D + + + + YF L
Sbjct: 655 SDDDNGRKKKKPSPLEKTGRLWGGLRNDLKRRMPMYKSDILDGLNTETLAATIFMYFACL 714
Query: 92 LPALAFAQDMFDRTDNSYGVNEVLLSSAIAGLVFGIIGGQPLCIVGVTGPISIFNYTVYE 151
A+ F + +T++ G++E L+S ++ G+VF + QPL I+G TGP+ +F+ +
Sbjct: 715 STAITFGGLVSAKTNSWIGISETLISCSLVGIVFHCLSCQPLVIIGTTGPLLLFDEALMV 774
Query: 152 IIMPLNIDYFGFMFWICIWSMITHFLLVIVNSVCLLQYVTTFPCDIFGLFINVVYIQKGI 211
D+ ++ +W +I + ++ +T F +IF I ++YI +
Sbjct: 775 FCTQHEFDFLSLRVYVGVWLIIIALTVSAFEGSVYVRLLTRFTQEIFSALITLIYIVETF 834
Query: 212 QILTRQFVDEN--SDFNL--------------------ASGYSSIM-------------- 235
L + + SD+NL AS ++I
Sbjct: 835 MKLISIYRENPLLSDYNLPPPTLVAHEHATNESLLNATASVTTNITQMVMNISTTAMPIG 894
Query: 236 ---------------VALLMAIFGLAF--KFFQLTPLLTYTMRTLISDYSTALSVVFWSG 278
L +A F +A+ K F+ + L R + D+ +S+
Sbjct: 895 PPPLPKNQPNTALFCTILTLATFVVAYYLKLFRNSHFLGRNARRALGDFGVPISIAI--- 951
Query: 279 FIHFGGLLDSVSFQKLPITKAFAPTRHGDSRQTW-LAYQDISVGDVFLALPFGIVLTILF 337
F+ L+ +V +KL + + +P+ S++ W + + S F + +++ IL
Sbjct: 952 FVLVDYLVPAVYTEKLVVPEGLSPS--DPSKRGWYIGFDTSSTWIPFACVIPALLVYILI 1009
Query: 338 YFDHNVSSLMAQRKEYKLRKASTFHYDFALLGITTGIAGVLGIPAPNGLIPQAPLHTQSL 397
+ + +S L+ + + L+K S H+D LL + G+ G+P ++ H S+
Sbjct: 1010 FMESQISELIVDKPDRGLKKGSGLHWDIVLLCLLNCACGIFGMPWHCAATVRSVTHVSSV 1069
Query: 398 LVRD------DDGNVIRCAEQRFTNTVQGLMI-LGTMTRPFLICLGLIPQAVLSGLFFIM 450
+ + ++ EQR + LMI L + P L LIP AVL G+F M
Sbjct: 1070 TIMSRTHAPGESPRIVDVKEQRLSGFFVCLMIGLSVLMAPLL---RLIPMAVLFGVFLYM 1126
Query: 451 GIQGLVSNTIVHRIWFVFTDPKKKSKDSTLNTVSTKSLLLFISLSLVGFVAEFAITNTKG 510
G+ + + RI F K S + + L LF ++ ++ V +++ +++
Sbjct: 1127 GVASMSGVQLFERIRLYFMPVKHYPPTSYVKRLRPWKLHLFTTIQVLCLVLLWSVKSSQF 1186
Query: 511 AIGFPIVLLLTVILSLFFPKIFPDKDLAILD 541
++ FP L++ V + K++ +++ LD
Sbjct: 1187 SLAFPFFLIMMVPIRQNLTKLYKPEEMQALD 1217
>Hs14042960 [P] KOG1172 Na+-independent Cl/HCO3 exchanger AE1 and related
transporters (SLC4 family)
Length = 891
Score = 131 bits (330), Expect = 2e-30
Identities = 126/586 (21%), Positives = 254/586 (42%), Gaps = 83/586 (14%)
Query: 27 IASQKSKDSDVEIQSIEKPR----KRFPPLCAGLIHDIKDKVPQYPSDW------KDSWD 76
+A + + S V + + P K F P G+ DI + P YP D+ K+
Sbjct: 313 VAPRTKERSTVSLPAHRHPEPPKCKDFVPFGKGIREDIARRFPLYPLDFTDGIIGKNKAV 372
Query: 77 YRVIPSVLETYFNNLLPALAFAQDMFDRTDNSYGVNEVLLSSAIAGLVFGIIGGQPLCIV 136
+ I + L YF LLP +AF + TD + V + + +I GL++ + GQPL I+
Sbjct: 373 GKYITTTLFLYFACLLPTIAFGSLNDENTDGAIDVQKTIAGQSIGGLLYALFSGQPLVIL 432
Query: 137 GVTGPISIFNYTVYEIIMPLNIDYFGFMFWICIWSMITHFLLVIVNSVCLLQYVTTFPCD 196
T P++++ + I ++D+ F W +W+ L N ++ +
Sbjct: 433 LTTAPLALYIQVIRVICDDYDLDFNSFYAWTGLWNSFFLALYAFFNLSLVMSLFKRSTEE 492
Query: 197 IFGLFINVVYIQKGIQILTRQF--------VDE-------------------NSDFNLA- 228
I LFI++ ++ ++ + F +D+ N+ + A
Sbjct: 493 IIALFISITFVLDAVKGTVKIFWKYYYGHYLDDYHTKRTSSLVSLSGLGASLNASLHTAL 552
Query: 229 ----------------SGYSSIMVALLMAI----FGLAFKFFQLTPLLTYTMRTLISDYS 268
SG ++ +++LL+ + G F+ +P L +R ++SD +
Sbjct: 553 NASFLASPTELPSATHSGQATAVLSLLIMLGTLWLGYTLYQFKKSPYLHPCVREILSDCA 612
Query: 269 TALSVVFWSGFIHFGGLLDSVSFQKLPITK-AFAPTRHGDSRQTWLAYQDISVGDVFLAL 327
++V+ +S L+ S F+++ ++K + P+ +S Q +S+ V A+
Sbjct: 613 LPIAVLAFS-------LISSHGFREIEMSKFRYNPS---ESPFAMAQIQSLSLRAVSGAM 662
Query: 328 PFGIVLTILFYFDHNVSSLMAQRKEYKLRKASTFHYDFALLGITTGIAGVLGIPAPNGLI 387
G +L++LF+ + N+ + + E +L K + +H+D LL I + G+P +
Sbjct: 663 GLGFLLSMLFFIEQNLVAALVNAPENRLVKGTAYHWDLLLLAIINTGLSLFGLPWIHAAY 722
Query: 388 PQAPLHTQSLLV---RDDDGN----VIRCAEQRFTNTVQGLMI-LGTMTRPFLICLGLIP 439
P +PLH ++L + R ++G+ ++ E R T+ +++ L + P + L IP
Sbjct: 723 PHSPLHVRALALVEERVENGHIYDTIVNVKETRLTSLGASVLVGLSLLLLP--VPLQWIP 780
Query: 440 QAVLSGLFFIMGIQGLVSNTIVHRIWFVFTDPKKKSKDSTLNTVSTKSLLLFISLSLVGF 499
+ VL GLF + + L N +V R+ + + + V + + F L ++
Sbjct: 781 KPVLYGLFLYIALTSLDGNQLVQRVALLLKEQTAYPPTHYIRRVPQRKIHYFTGLQVLQL 840
Query: 500 VAEFAITNTK---GAIGFPIVLLLTV-ILSLFFPKIFPDKDLAILD 541
+ A + + FP++++ + I + P+I K L ++D
Sbjct: 841 LLLCAFGMSSLPYMKMIFPLIMIAMIPIRYILLPRIIEAKYLDVMD 886
>Hs11545763 [P] KOG1172 Na+-independent Cl/HCO3 exchanger AE1 and related
transporters (SLC4 family)
Length = 1088
Score = 129 bits (325), Expect = 9e-30
Identities = 126/564 (22%), Positives = 232/564 (40%), Gaps = 79/564 (14%)
Query: 55 GLIHDIKDKVPQYPSDWKDSWDYRVIPSVLETYFNNLLPALAFAQDMFDRTDNSYGVNEV 114
GLI DIK K P + SD++D++ + + S L Y + P + F + + T+ E
Sbjct: 455 GLILDIKRKAPYFWSDFRDAFSLQCLASFLFLYCACMSPVITFGGLLGEATEGRISAIES 514
Query: 115 LLSSAIAGLVFGIIGGQPLCIVGVTGPISIFNYTVYEIIMPLNIDYFGFMFWICIWSMIT 174
L +++ G+ + + GGQPL I+G TGP+ +F +++ + Y I +W+
Sbjct: 515 LFGASMTGIAYSLFGGQPLTILGSTGPVLVFEKILFKFCKEYGLSYLSLRASIGLWTATL 574
Query: 175 HFLLVIVNSVCLLQYVTTFPCDIFGLFINVVYIQKGIQILTRQF----VDENSDFNLASG 230
+LV ++ L+ Y+T F + F I +++I + ++ L ++ ++D L +
Sbjct: 575 CIILVATDASSLVCYITRFTEEAFASLICIIFIYEALEKLFELSEAYPINMHNDLELLTQ 634
Query: 231 YSSIMVALLMAIFGLAFKFFQ--------LTPLLT----------YTMRTLISDYSTALS 272
YS V G ++ + + LT Y R D+
Sbjct: 635 YSCNCVEPHNPSNGTLKEWRESNISASDIIWENLTVSECKSLHGEYVGRACGHDHPYVPD 694
Query: 273 VVFWSGFIHFGGLLDSVSFQKLPITKAFAPTRHGDSRQTWLAYQ--------DISVG--- 321
V+FWS + F + S + ++ ++ F PT+ + + D ++G
Sbjct: 695 VLFWSVILFFSTVTLSATLKQFKTSRYF-PTKVRSIVSDFAVFLTILCMVLIDYAIGIPS 753
Query: 322 -----------------------------DVFLALPFGIVLTILFYFDHNVSSLMAQRKE 352
V A+ ++ TIL + D +++++ RKE
Sbjct: 754 PKLQVPSVFKPTRDDRGWFVTPLGPNPWWTVIAAIIPALLCTILIFMDQQITAVIINRKE 813
Query: 353 YKLRKASTFHYDFALLGITTGIAGVLGIPAPNGLIPQAPLHTQSLLVRD------DDGNV 406
+KL+K +H D ++ + G+ ++G+P + H SL + +
Sbjct: 814 HKLKKGCGYHLDLLMVAVMLGVCSIMGLPWFVAATVLSITHVNSLKLESECSAPGEQPKF 873
Query: 407 IRCAEQRFTNTVQGLMILGTMTRPFLI--CLGLIPQAVLSGLFFIMGIQGLVSNTIVHRI 464
+ EQR T GLMI M + L IP VL G+F MG L RI
Sbjct: 874 LGIREQRVT----GLMIFILMGSSVFMTSILKFIPMPVLYGVFLYMGASSLKGIQFFDRI 929
Query: 465 WFVFTDPKKKSKDSTLNTVSTKSLLLF--ISLSLVGFVAEFAITNTKGAIGFPIVLLLTV 522
+ K + L V + + LF I +S +G + + I ++ AI P+++L V
Sbjct: 930 KLFWMPAKHQPDFIYLRHVPLRKVHLFTIIQMSCLGLL--WIIKVSRAAIVSPMMVLSLV 987
Query: 523 ILSLFFPKIFPDKDLAILDEPVSE 546
+ +F ++L LD+ + E
Sbjct: 988 FVRKLMDLLFTKRELCWLDDLMPE 1011
>CE28743 [P] KOG1172 Na+-independent Cl/HCO3 exchanger AE1 and related
transporters (SLC4 family)
Length = 881
Score = 126 bits (317), Expect = 8e-29
Identities = 112/493 (22%), Positives = 212/493 (42%), Gaps = 46/493 (9%)
Query: 33 KDSDVEIQSIEKPRKRFPP---LCAGLIHDIKDKVPQYPSDWKDSWDYRVIPSVLETYFN 89
KD DVE + +K + L +G+ D++++ Y SD++D ++ + V +
Sbjct: 339 KDVDVERNATKKAEEAEDKPFRLFSGVTSDLRNRAKHYFSDYRDGFNISIFTVVFYMFCV 398
Query: 90 NLLPALAFAQDMFDRTDNSYGVNEVLLSSAIAGLVFGIIGGQPLCIVGVTGPISIFNYTV 149
++P L F M T V E L+S A++GL++ ++ QPL ++ TGP +F +
Sbjct: 399 TVVPTLTFGAIMGAGTSGLLAVKECLVSQALSGLIWSVLSCQPLLVMSPTGPFLVFEKAL 458
Query: 150 YEIIMPLNIDYFGFMFWICIWSMITHFLLVIVNSVCLLQYVTTFPCDIFGLFINVVYIQK 209
++ ++D+ F+ I+ + N L+ YVT + DIF I++++ +
Sbjct: 459 FKFTDQNDMDFLEVRFYTGIFLFFISIVGAATNCAHLIHYVTIYTEDIFCALISLIFFSE 518
Query: 210 GIQILTRQFVDENSDFNL-------------------ASGYSSIMVALLMAIFGLA-FKF 249
++ + Q + NS NL S ++ ++ L+M + +A F +
Sbjct: 519 VVEFIHLQ-EEHNSIENLKYYIENAANCTVTEVKDCALSRPNTFLLQLIMVVVSIAIFHY 577
Query: 250 FQLTPLLTY---TMRTLISDYSTALSVVFWSGFIHFGGLLDSVSFQKLPITKAFAPTRHG 306
+ T+ T R L ++ +V+ S + + FQ + + P G
Sbjct: 578 LRQVSRSTFFGRTFRNLCKNFGGIFAVIAVS-------IAYRILFQNVGVAVVDIPVAVG 630
Query: 307 DSRQ----TWLAYQDISVGDVFLALPFGIVLTILFYFDHNVSSLMAQRKEYKLRKASTFH 362
SR + + + +AL I+L +L + + + MA R+ KL+K H
Sbjct: 631 QSRPFDGIFVIPSAPPTASTLTIALISSILLFVLIFVETEIPEQMALREGRKLKKGGGLH 690
Query: 363 YDFALLGITTGIAGVLGIPAPNGLIPQAPLHTQSLLVRDDD-----GNVIRCAEQRFTNT 417
+D ++G T ++ VLG+P Q+ H SL + EQR +
Sbjct: 691 WDLIVVGFCTLVSSVLGLPWMCPAAVQSLAHITSLTEYKKSAPGVPSRISHVIEQRVSGM 750
Query: 418 VQGLMILGTMTRPFLICLGLIPQAVLSGLFFIMGIQGLVSNTIVHRIWFVFTDPKKKSKD 477
V ++LGT L IP A + G+FF +G++ L + ++ R+ F K +
Sbjct: 751 VT-YLLLGTFA--ILGHFLAIPAATIFGVFFYLGVRNLEGSKMILRLKLCFLPSKYRGSH 807
Query: 478 STLNTVSTKSLLL 490
L VS+ + +
Sbjct: 808 KFLEIVSSLKICI 820
>CE27167 [P] KOG1172 Na+-independent Cl/HCO3 exchanger AE1 and related
transporters (SLC4 family)
Length = 1119
Score = 111 bits (277), Expect = 3e-24
Identities = 55/184 (29%), Positives = 95/184 (50%)
Query: 33 KDSDVEIQSIEKPRKRFPPLCAGLIHDIKDKVPQYPSDWKDSWDYRVIPSVLETYFNNLL 92
++ ++ + KR L GLI DIK K P + SD+ D+++ + + S+ YF L
Sbjct: 382 EEEEIHSHGDDPALKRTGKLFGGLILDIKRKAPHFVSDFTDAFNLQCLASICFMYFGLLA 441
Query: 93 PALAFAQDMFDRTDNSYGVNEVLLSSAIAGLVFGIIGGQPLCIVGVTGPISIFNYTVYEI 152
P + F + + T E L A+ G+++ GQPL IVG TGP+ +F V++
Sbjct: 442 PIVTFGGLLEEATHQRMAAMENLFGGALCGVIYHFFAGQPLTIVGSTGPVLVFETIVFDF 501
Query: 153 IMPLNIDYFGFMFWICIWSMITHFLLVIVNSVCLLQYVTTFPCDIFGLFINVVYIQKGIQ 212
I Y F FW+ +W+ + FL+V+ ++ L+ ++T F + F I V++I + I
Sbjct: 502 CHRFGIVYLSFRFWVHVWTAVIIFLMVVTDASALVSFITRFTEESFATLIAVIFIYEAIM 561
Query: 213 ILTR 216
L +
Sbjct: 562 KLVK 565
Score = 92.4 bits (228), Expect = 2e-18
Identities = 89/336 (26%), Positives = 143/336 (42%), Gaps = 46/336 (13%)
Query: 238 LLMAIFGLAFKFFQLTPL--------LTYTMRTLISDYSTALSVVFWSGFIHFGGLLDSV 289
LLM+I FF T L ++R L+SD++ +++ + F + V
Sbjct: 648 LLMSILLTVGTFFLATTLKKMRNSCYFPSSVRQLLSDFAVMIAIASMT----FVDIFVGV 703
Query: 290 SFQKLPITKAFAPTRHG--------DSRQTWLAYQDISVGDVFLALPFGIVLTILFYFDH 341
+ KL + F PT G D+ + W A LA+ ++ IL + D
Sbjct: 704 NTPKLNVPSTFRPTWEGRGWFIPPFDANEWWTAP---------LAILPALLACILIFMDQ 754
Query: 342 NVSSLMAQRKEYKLRKASTFHYDFALLGITTGIAGVLGIPAPNGLIPQAPLHTQSLLVRD 401
+++++ RKE KL+K +H D +L ++ + G LG+P + H SL V
Sbjct: 755 QITTVIVNRKENKLKKGCGYHLDLLVLSVSILMVGFLGLPIYVAATVLSINHINSLKVES 814
Query: 402 D---DGNV---IRCAEQRFTNTVQ----GLMILGTMTRPFLICLGLIPQAVLSGLFFIMG 451
+ G V + EQR T V GL +L T LG IP VL G+F MG
Sbjct: 815 ECKAPGEVAQFVGVREQRVTGIVTFLIIGLSVLATN------ILGRIPMPVLYGVFLYMG 868
Query: 452 IQGLVSNTIVHRIWFVFTDPKKKSKDSTLNTVSTKSLLLFISLSLVGFVAEFAITNTKG- 510
I L + R +F K + + V + + LF + + + I + K
Sbjct: 869 ISALGGIQLFDRTLLLFMPMKYQPDTIYIRHVPIRKIHLFTAFQIGCLALLWVIKSIKST 928
Query: 511 AIGFPIVLLLTVILSLFFPKIFPDKDLAILDEPVSE 546
+I FPI+L++ V + K F DL LD+P+ +
Sbjct: 929 SILFPIMLVVMVAIRKMMEKAFTTTDLKYLDDPMPD 964
>Hs4507025 [P] KOG1172 Na+-independent Cl/HCO3 exchanger AE1 and related
transporters (SLC4 family)
Length = 1035
Score = 109 bits (272), Expect = 1e-23
Identities = 60/184 (32%), Positives = 97/184 (52%), Gaps = 4/184 (2%)
Query: 53 CAGLIHDIKDKVPQYPSDWKDSWDYRVIPSVLETYFNNLLPALAFAQDMFDRTDNSYGVN 112
C GLI DIK K P + SD+ D+ + + + ++L Y + A+ F + D TDN GV
Sbjct: 399 CGGLIKDIKRKAPFFASDFYDALNIQALSAILFIYLATVTNAITFGGLLGDATDNMQGVL 458
Query: 113 EVLLSSAIAGLVFGIIGGQPLCIVGVTGPISIFNYTVYEIIMPLNIDYFGFMFWICIWSM 172
E L +A++G +F + GQPL I+ TGP+ +F ++ N DY F WI +WS
Sbjct: 459 ESFLGTAVSGAIFCLFAGQPLTILSSTGPVLVFERLLFNFSKDNNFDYLEFRLWIGLWSA 518
Query: 173 ITHFLLVIVNSVCLLQYVTTFPCDIFGLFINVVYIQKGIQ--ILTRQFVDENSDFNLASG 230
+LV ++ L+QY T F + F I+ ++I + I + NS+F + G
Sbjct: 519 FLCLILVATDASFLVQYFTRFTEEGFSSLISFIFIYDAFKKMIKLADYYPINSNFKV--G 576
Query: 231 YSSI 234
Y+++
Sbjct: 577 YNTL 580
Score = 86.7 bits (213), Expect = 9e-17
Identities = 78/310 (25%), Positives = 138/310 (44%), Gaps = 15/310 (4%)
Query: 245 LAFKFFQLTPLLTYTMRTLISDYSTALSVVFWSGFIHFGGLLDSVSFQKLPITKAFAPTR 304
+A K F+ +P T R LISD++ LS++ + L V KL + F PT
Sbjct: 664 MALKKFKTSPYFPTTARKLISDFAIILSILIFCVI----DALVGVDTPKLIVPSEFKPT- 718
Query: 305 HGDSRQTWLAYQDISVGDVFLALPF-GIVLTILFYFDHNVSSLMAQRKEYKLRKASTFHY 363
+R ++ + V LA +++TIL + D +++++ RKE+KL+K + +H
Sbjct: 719 -SPNRGWFVPPFGENPWWVCLAAAIPALLVTILIFMDQQITAVIVNRKEHKLKKGAGYHL 777
Query: 364 DFALLGITTGIAGVLGIPAPNGLIPQAPLHTQSLLVRDDDG------NVIRCAEQRFTNT 417
D + I I ++ +P + H SL + + + EQR T T
Sbjct: 778 DLFWVAILMVICSLMALPWYVAATVISIAHIDSLKMETETSAPGEQPKFLGVREQRVTGT 837
Query: 418 VQGLMILGTMTRPFLICLGLIPQAVLSGLFFIMGIQGLVSNTIVHRIWFVFTDPKKKSKD 477
+ + IL ++ L IP VL G+F MG+ L + R+ + K +
Sbjct: 838 L--VFILTGLSVFMAPILKFIPMPVLYGVFLYMGVASLNGVQFMDRLKLLLMPLKHQPDF 895
Query: 478 STLNTVSTKSLLLFISLSLVGFVAEFAITNTKGAIGFPIVLLLTVILSLFFPKIFPDKDL 537
L V + + LF L ++ + + +T AI FP+++L V + +F DL
Sbjct: 896 IYLRHVPLRRVHLFTFLQVLCLALLWILKSTVAAIIFPVMILALVAVRKGMDYLFSQHDL 955
Query: 538 AILDEPVSEE 547
+ LD+ + E+
Sbjct: 956 SFLDDVIPEK 965
>Hs22049645 [P] KOG1172 Na+-independent Cl/HCO3 exchanger AE1 and related
transporters (SLC4 family)
Length = 983
Score = 102 bits (255), Expect = 1e-21
Identities = 53/160 (33%), Positives = 85/160 (53%)
Query: 52 LCAGLIHDIKDKVPQYPSDWKDSWDYRVIPSVLETYFNNLLPALAFAQDMFDRTDNSYGV 111
L GLI D++ KVP YPSD+ D+ + +VL Y + A+ F + D TD + GV
Sbjct: 385 LFGGLIQDVRRKVPWYPSDFLDALHLQCFSAVLYIYLATVTNAITFGGLLGDATDGAQGV 444
Query: 112 NEVLLSSAIAGLVFGIIGGQPLCIVGVTGPISIFNYTVYEIIMPLNIDYFGFMFWICIWS 171
E L +A+AG F ++ GQPL I+ TGP+ +F ++ ++DY F W+ IW
Sbjct: 445 LESFLGTAVAGAAFCLMAGQPLTILSSTGPVLVFERLLFSFSRDYSLDYLPFRLWVGIWV 504
Query: 172 MITHFLLVIVNSVCLLQYVTTFPCDIFGLFINVVYIQKGI 211
+LV + L++Y T F + F I++++I +
Sbjct: 505 ATFCLVLVATEASVLVRYFTRFTEEGFCALISLIFIYDAV 544
Score = 93.6 bits (231), Expect = 7e-19
Identities = 86/326 (26%), Positives = 145/326 (44%), Gaps = 19/326 (5%)
Query: 231 YSSIMVALLMAIFGLAFKFFQLTPLLTYTMRTLISDYSTALSVVFWSGFIHFGGLLDSVS 290
+ S+++ L F +A K + + +R +SD+S+ L+++ G F GL +
Sbjct: 629 FFSLLLFLTSFFFAMALKCVKTSRFFPSVVRKGLSDFSSVLAILLGCGLDAFLGL----A 684
Query: 291 FQKLPITKAFAPTRHGDSRQTWLAYQ---DISVGDVFLALPFGIVLTILFYFDHNVSSLM 347
KL + + F PT G + WL + V ALP ++L+IL + D +++++
Sbjct: 685 TPKLMVPREFKPTLPG---RGWLVSPFGANPWWWSVAAALP-ALLLSILIFMDQQITAVI 740
Query: 348 AQRKEYKLRKASTFHYDFALLGITTGIAGVLGIPAPNGLIPQAPLHTQSL------LVRD 401
R EY+L+K + FH D + + + LG+P + H SL
Sbjct: 741 LNRMEYRLQKGAGFHLDLFCVAVLMLLTSALGLPWYVSATVISLAHMDSLRRESRACAPG 800
Query: 402 DDGNVIRCAEQRFTNTVQGLMILGTMTRPFLICLGLIPQAVLSGLFFIMGIQGLVSNTIV 461
+ N + EQR T V + IL + L IP VL G+F MG+ L S
Sbjct: 801 ERPNFLGIREQRLTGLV--VFILTGASIFLAPVLKFIPMPVLYGIFLYMGVAALSSIQFT 858
Query: 462 HRIWFVFTDPKKKSKDSTLNTVSTKSLLLFISLSLVGFVAEFAITNTKGAIGFPIVLLLT 521
+R+ + K + L V + LF ++ L + I +T AI FP++LL
Sbjct: 859 NRVKLLLMPAKHQPDLLLLRHVPLTRVHLFTAIQLACLGLLWIIKSTPAAIIFPLMLLGL 918
Query: 522 VILSLFFPKIFPDKDLAILDEPVSEE 547
V + ++F ++L LDE + EE
Sbjct: 919 VGVRKALERVFSPQELLWLDELMPEE 944
>CE28338 [P] KOG1172 Na+-independent Cl/HCO3 exchanger AE1 and related
transporters (SLC4 family)
Length = 642
Score = 101 bits (252), Expect = 3e-21
Identities = 80/308 (25%), Positives = 144/308 (45%), Gaps = 24/308 (7%)
Query: 104 RTDNSYGVNEVLLSSAIAGLVFGIIGGQPLCIVGVTGPISIFNYTVYEIIMPLNIDYFGF 163
++D V +V+L I L+FGI GGQ L I+ T P+SI+ +Y++ + D+F
Sbjct: 245 KSDYLDDVQKVVLGQWIGSLLFGIFGGQQLLILSTTAPLSIYIAVIYQVAQTNDWDFFQM 304
Query: 164 MFWICIWSMITHFLLVIVNSVCLLQYVTTFPCDIFGLFINVVYIQKGIQILTRQFVD--- 220
+ I++M L + L+++ T +IF +FI + I K I + +
Sbjct: 305 YASVGIYAMGLLILASVFQLASLMKFTTRSTEEIFSVFIALALIIKAIMAIVHVYTHGYL 364
Query: 221 ---ENSDFNLASGYSSIMVALLM---AIFGLAFKFFQLTPLLTYTMRTLISDYSTALSVV 274
N +L ++ L+ + F+ +P L+ R L+SDY+ ++V+
Sbjct: 365 GCINNVAGDLCDPAEPLLFIFLLFGTTWLSMTIISFRSSPYLSRWKRDLVSDYALPIAVL 424
Query: 275 FWSGFIHFGGLLDSVSFQKLPITKAFAPTRHGDSRQT---WLAYQDISVGDVFLALPFGI 331
+S FI F G D V ++ I SR+T ++ + ++ A+ I
Sbjct: 425 VFS-FISFFGFSD-VKKEQFQIF----------SRETDAFFVPFFNLPAEAQLPAVGLAI 472
Query: 332 VLTILFYFDHNVSSLMAQRKEYKLRKASTFHYDFALLGITTGIAGVLGIPAPNGLIPQAP 391
L+ILF+ D + + K+ KL+K S H+D ++G+ + G+P +G +P A
Sbjct: 473 PLSILFFMDQLLVTNTVDNKDNKLKKGSAHHWDLLVVGVLNIGLSIFGLPWMHGALPSAY 532
Query: 392 LHTQSLLV 399
LH ++L V
Sbjct: 533 LHLKALSV 540
>Hs19743830 [P] KOG1172 Na+-independent Cl/HCO3 exchanger AE1 and related
transporters (SLC4 family)
Length = 1040
Score = 101 bits (251), Expect = 3e-21
Identities = 55/164 (33%), Positives = 89/164 (53%)
Query: 55 GLIHDIKDKVPQYPSDWKDSWDYRVIPSVLETYFNNLLPALAFAQDMFDRTDNSYGVNEV 114
GL DIK K+P +PSD+ D + + I ++L Y + A+ F + D TDN GV E
Sbjct: 497 GLCLDIKRKLPWFPSDFYDGFHIQSISAILFIYLGCITNAITFGGLLGDATDNYQGVMES 556
Query: 115 LLSSAIAGLVFGIIGGQPLCIVGVTGPISIFNYTVYEIIMPLNIDYFGFMFWICIWSMIT 174
L +A+AG +F + GQPL I+ TGPI IF +++ +DY F WI + S +
Sbjct: 557 FLGTAMAGSLFCLFSGQPLIILSSTGPILIFEKLLFDFSKGNGLDYMEFRLWIGLHSAVQ 616
Query: 175 HFLLVIVNSVCLLQYVTTFPCDIFGLFINVVYIQKGIQILTRQF 218
+LV ++ +++Y+T F + F I+ ++I I+ + F
Sbjct: 617 CLILVATDASFIIKYITRFTEEGFSTLISFIFIYDAIKKMIGAF 660
Score = 56.6 bits (135), Expect = 1e-07
Identities = 52/203 (25%), Positives = 90/203 (43%), Gaps = 16/203 (7%)
Query: 245 LAFKFFQLTPLLTYTMRTLISDYSTALSVVFWSGFIHFGGLLDSVSFQKLPITKAFAPTR 304
L K F+ + +R L++D+S S++ + G GL KL + PTR
Sbjct: 759 LTLKKFKFSRYFPTKVRALVADFSIVFSILMFCGIDACFGL----ETPKLHVPSVIKPTR 814
Query: 305 HGDSRQTWLAYQDISVGDVFLA--LPFGIVLTILFYFDHNVSSLMAQRKEYKLRKASTFH 362
R ++A + V+ A LP +++TIL + D +++++ RKE KL+KA+ +H
Sbjct: 815 --PDRGWFVAPFGKNPWWVYPASILP-ALLVTILIFMDQQITAVIVNRKENKLKKAAGYH 871
Query: 363 YDFALLGITTGIAGVLGIPAPNGLIPQAPLHTQSLLVRDDDG------NVIRCAEQRFTN 416
D +GI + +G+P + H SL + + + EQR T
Sbjct: 872 LDLFWVGILMALCSFMGLPWYVAATVISIAHIDSLKMETETSAPGEQPQFLGVREQRVTG 931
Query: 417 TVQGLMI-LGTMTRPFLICLGLI 438
+ ++ + P L LGLI
Sbjct: 932 IIVFILTGISVFLAPILKILGLI 954
>Hs19743827 [P] KOG1172 Na+-independent Cl/HCO3 exchanger AE1 and related
transporters (SLC4 family)
Length = 1121
Score = 101 bits (251), Expect = 3e-21
Identities = 55/164 (33%), Positives = 89/164 (53%)
Query: 55 GLIHDIKDKVPQYPSDWKDSWDYRVIPSVLETYFNNLLPALAFAQDMFDRTDNSYGVNEV 114
GL DIK K+P +PSD+ D + + I ++L Y + A+ F + D TDN GV E
Sbjct: 497 GLCLDIKRKLPWFPSDFYDGFHIQSISAILFIYLGCITNAITFGGLLGDATDNYQGVMES 556
Query: 115 LLSSAIAGLVFGIIGGQPLCIVGVTGPISIFNYTVYEIIMPLNIDYFGFMFWICIWSMIT 174
L +A+AG +F + GQPL I+ TGPI IF +++ +DY F WI + S +
Sbjct: 557 FLGTAMAGSLFCLFSGQPLIILSSTGPILIFEKLLFDFSKGNGLDYMEFRLWIGLHSAVQ 616
Query: 175 HFLLVIVNSVCLLQYVTTFPCDIFGLFINVVYIQKGIQILTRQF 218
+LV ++ +++Y+T F + F I+ ++I I+ + F
Sbjct: 617 CLILVATDASFIIKYITRFTEEGFSTLISFIFIYDAIKKMIGAF 660
Score = 85.9 bits (211), Expect = 1e-16
Identities = 78/312 (25%), Positives = 136/312 (43%), Gaps = 19/312 (6%)
Query: 245 LAFKFFQLTPLLTYTMRTLISDYSTALSVVFWSGFIHFGGLLDSVSFQKLPITKAFAPTR 304
L K F+ + +R L++D+S S++ + G GL KL + PTR
Sbjct: 759 LTLKKFKFSRYFPTKVRALVADFSIVFSILMFCGIDACFGL----ETPKLHVPSVIKPTR 814
Query: 305 HGDSRQTWLAYQDISVGDVFLA--LPFGIVLTILFYFDHNVSSLMAQRKEYKLRKASTFH 362
R ++A + V+ A LP +++TIL + D +++++ RKE KL+KA+ +H
Sbjct: 815 --PDRGWFVAPFGKNPWWVYPASILP-ALLVTILIFMDQQITAVIVNRKENKLKKAAGYH 871
Query: 363 YDFALLGITTGIAGVLGIPAPNGLIPQAPLHTQSLLVRDDDG------NVIRCAEQRFTN 416
D +GI + +G+P + H SL + + + EQR T
Sbjct: 872 LDLFWVGILMALCSFMGLPWYVAATVISIAHIDSLKMETETSAPGEQPQFLGVREQRVTG 931
Query: 417 TVQGLMI-LGTMTRPFLICLGLIPQAVLSGLFFIMGIQGLVSNTIVHRIWFVFTDPKKKS 475
+ ++ + P L C IP VL G+F MG+ L R K +
Sbjct: 932 IIVFILTGISVFLAPILKC---IPLPVLYGVFLYMGVASLNGIQFWERCKLFLMPAKHQP 988
Query: 476 KDSTLNTVSTKSLLLFISLSLVGFVAEFAITNTKGAIGFPIVLLLTVILSLFFPKIFPDK 535
+ L V + + LF + ++ + + +T AI FP+++L +I+ IF
Sbjct: 989 DHAFLRHVPLRRIHLFTLVQILCLAVLWILKSTVAAIIFPVMILGLIIVRRLLDFIFSQH 1048
Query: 536 DLAILDEPVSEE 547
DLA +D + E+
Sbjct: 1049 DLAWIDNILPEK 1060
>Hs19743825 [P] KOG1172 Na+-independent Cl/HCO3 exchanger AE1 and related
transporters (SLC4 family)
Length = 1074
Score = 101 bits (251), Expect = 3e-21
Identities = 55/164 (33%), Positives = 89/164 (53%)
Query: 55 GLIHDIKDKVPQYPSDWKDSWDYRVIPSVLETYFNNLLPALAFAQDMFDRTDNSYGVNEV 114
GL DIK K+P +PSD+ D + + I ++L Y + A+ F + D TDN GV E
Sbjct: 497 GLCLDIKRKLPWFPSDFYDGFHIQSISAILFIYLGCITNAITFGGLLGDATDNYQGVMES 556
Query: 115 LLSSAIAGLVFGIIGGQPLCIVGVTGPISIFNYTVYEIIMPLNIDYFGFMFWICIWSMIT 174
L +A+AG +F + GQPL I+ TGPI IF +++ +DY F WI + S +
Sbjct: 557 FLGTAMAGSLFCLFSGQPLIILSSTGPILIFEKLLFDFSKGNGLDYMEFRLWIGLHSAVQ 616
Query: 175 HFLLVIVNSVCLLQYVTTFPCDIFGLFINVVYIQKGIQILTRQF 218
+LV ++ +++Y+T F + F I+ ++I I+ + F
Sbjct: 617 CLILVATDASFIIKYITRFTEEGFSTLISFIFIYDAIKKMIGAF 660
Score = 67.4 bits (163), Expect = 5e-11
Identities = 74/302 (24%), Positives = 128/302 (41%), Gaps = 35/302 (11%)
Query: 245 LAFKFFQLTPLLTYTMRTLISDYSTALSVVFWSGFIHFGGLLDSVSFQKLPITKAFAPTR 304
L K F+ + +R L++D+S S++ + G GL KL + PTR
Sbjct: 759 LTLKKFKFSRYFPTKVRALVADFSIVFSILMFCGIDACFGL----ETPKLHVPSVIKPTR 814
Query: 305 HGDSRQTWLAYQDISVGDVFLA--LPFGIVLTILFYFDHNVSSLMAQRKEYKLRKASTFH 362
R ++A + V+ A LP +++TIL + D +++++ RKE KL+KA+ +H
Sbjct: 815 --PDRGWFVAPFGKNPWWVYPASILP-ALLVTILIFMDQQITAVIVNRKENKLKKAAGYH 871
Query: 363 YDFALLGITTGIAGVLGIPAPNGLIPQAPLHTQSLLVRDDDG------NVIRCAEQRFTN 416
D +GI + +G+P + H SL + + + EQR T
Sbjct: 872 LDLFWVGILMALCSFMGLPWYVAATVISIAHIDSLKMETETSAPGEQPQFLGVREQRVTG 931
Query: 417 TVQGLMI-LGTMTRPFLICLGLIPQAVLSGLFFIMGIQGLVSNTI------------VHR 463
+ ++ + P L C IP VL G+F MG+ L + +
Sbjct: 932 IIVFILTGISVFLAPILKC---IPLPVLYGVFLYMGVASLNGIQMGTGGSEFKIQKKLTP 988
Query: 464 IW---FVFTDPKKKSKD-STLNTVSTKSLLLFISLSLVGFVAEFAITNTKGAIGFPIVLL 519
W +F P K D + L V + + LF + ++ + + +T AI FP++ L
Sbjct: 989 FWERCKLFLMPAKHQPDHAFLRHVPLRRIHLFTLVQILCLAVLWILKSTVAAIIFPVMSL 1048
Query: 520 LT 521
T
Sbjct: 1049 ST 1050
>Hs15042959 [P] KOG1172 Na+-independent Cl/HCO3 exchanger AE1 and related
transporters (SLC4 family)
Length = 1137
Score = 101 bits (251), Expect = 3e-21
Identities = 55/164 (33%), Positives = 89/164 (53%)
Query: 55 GLIHDIKDKVPQYPSDWKDSWDYRVIPSVLETYFNNLLPALAFAQDMFDRTDNSYGVNEV 114
GL DIK K+P +PSD+ D + + I ++L Y + A+ F + D TDN GV E
Sbjct: 497 GLCLDIKRKLPWFPSDFYDGFHIQSISAILFIYLGCITNAITFGGLLGDATDNYQGVMES 556
Query: 115 LLSSAIAGLVFGIIGGQPLCIVGVTGPISIFNYTVYEIIMPLNIDYFGFMFWICIWSMIT 174
L +A+AG +F + GQPL I+ TGPI IF +++ +DY F WI + S +
Sbjct: 557 FLGTAMAGSLFCLFSGQPLIILSSTGPILIFEKLLFDFSKGNGLDYMEFRLWIGLHSAVQ 616
Query: 175 HFLLVIVNSVCLLQYVTTFPCDIFGLFINVVYIQKGIQILTRQF 218
+LV ++ +++Y+T F + F I+ ++I I+ + F
Sbjct: 617 CLILVATDASFIIKYITRFTEEGFSTLISFIFIYDAIKKMIGAF 660
Score = 75.5 bits (184), Expect = 2e-13
Identities = 80/328 (24%), Positives = 140/328 (42%), Gaps = 35/328 (10%)
Query: 245 LAFKFFQLTPLLTYTMRTLISDYSTALSVVFWSGFIHFGGLLDSVSFQKLPITKAFAPTR 304
L K F+ + +R L++D+S S++ + G GL KL + P R
Sbjct: 759 LTLKKFKFSRYFPTKVRALVADFSIVFSILMFCGIDACFGL----ETPKLHVPSVIKPPR 814
Query: 305 HGDSRQTWLAYQDISVGDVFLA--LPFGIVLTILFYFDHNVSSLMAQRKEYKLRKASTFH 362
R ++A + V+ A LP +++TIL + D +++++ RKE KL+KA+ +H
Sbjct: 815 --PDRGWFVAPFGKNPWWVYPASILP-ALLVTILIFMDQQITAVIVNRKENKLKKAAGYH 871
Query: 363 YDFALLGITTGIAGVLGIPAPNGLIPQAPLHTQSLLVRDDDG------NVIRCAEQRFTN 416
D +GI + +G+P + H SL + + + EQR T
Sbjct: 872 LDLFWVGILMALCSFMGLPWYVAATVISIAHIDSLKMETETSAPGEQPQFLGVREQRVTG 931
Query: 417 TVQGLMI-LGTMTRPFLICLGLIPQAVLSGLFFIMGIQGLVSNTI------------VHR 463
+ ++ + P L C IP VL G+F MG+ L + +
Sbjct: 932 IIVFILTGISVFLAPILKC---IPLPVLYGVFLYMGVASLNGIQMGTGGSEFKIQKKLTP 988
Query: 464 IW---FVFTDPKKKSKD-STLNTVSTKSLLLFISLSLVGFVAEFAITNTKGAIGFPIVLL 519
W +F P K D + L V + + LF + ++ + + +T AI FP+++L
Sbjct: 989 FWERCKLFLMPAKHQPDHAFLRHVPLRRIHLFTLVQILCLAVLWILKSTVAAIIFPVMIL 1048
Query: 520 LTVILSLFFPKIFPDKDLAILDEPVSEE 547
+I+ IF DLA +D + E+
Sbjct: 1049 GLIIVRRLLDFIFSQHDLAWIDNILPEK 1076
>Hs19923176 [P] KOG1172 Na+-independent Cl/HCO3 exchanger AE1 and related
transporters (SLC4 family)
Length = 1214
Score = 89.4 bits (220), Expect = 1e-17
Identities = 46/163 (28%), Positives = 83/163 (50%)
Query: 52 LCAGLIHDIKDKVPQYPSDWKDSWDYRVIPSVLETYFNNLLPALAFAQDMFDRTDNSYGV 111
L GLI DIK K P + SD+KD+ + + S+L Y + P + F + + T+
Sbjct: 581 LFGGLILDIKRKAPFFLSDFKDALSLQCLASILFLYCACMSPVITFGGLLGEATEGRISA 640
Query: 112 NEVLLSSAIAGLVFGIIGGQPLCIVGVTGPISIFNYTVYEIIMPLNIDYFGFMFWICIWS 171
E L +++ G+ + + GQPL I+G TGP+ +F +Y+ + Y I +W+
Sbjct: 641 IESLFGASLTGIAYSLFAGQPLTILGSTGPVLVFEKILYKFCRDYQLSYLSLRTSIGLWT 700
Query: 172 MITHFLLVIVNSVCLLQYVTTFPCDIFGLFINVVYIQKGIQIL 214
+LV ++ L+ Y+T F + F I +++I + ++ L
Sbjct: 701 SFLCIVLVATDASSLVCYITRFTEEAFAALICIIFIYEALEKL 743
Score = 84.7 bits (208), Expect = 3e-16
Identities = 86/328 (26%), Positives = 143/328 (43%), Gaps = 33/328 (10%)
Query: 236 VALLMAIFGLA--FKFFQLTPLLTYTMRTLISDYSTALSVVFWSGFIHFGGLLDSVSFQK 293
V L F L+ K F+ +R+ ISD++ L++V + G V K
Sbjct: 829 VILFFTTFFLSSFLKQFKTKRYFPTKVRSTISDFAVFLTIVIMVTIDYLVG----VPSPK 884
Query: 294 LPITKAFAPTRHGDSRQTWLAYQDISVGD------VFLALPFGIVLTILFYFDHNVSSLM 347
L + + F PT + W+ +GD + A+P ++ TIL + D +++++
Sbjct: 885 LHVPEKFEPTH---PERGWIISP---LGDNPWWTLLIAAIP-ALLCTILIFMDQQITAVI 937
Query: 348 AQRKEYKLRKASTFHYDFALLGITTGIAGVLGIPAPNGLIPQAPLHTQSLLVRD------ 401
RKE+KL+K + +H D ++G+ G+ V+G+P + H SL V
Sbjct: 938 INRKEHKLKKGAGYHLDLLMVGVMLGVCSVMGLPWFVAATVLSISHVNSLKVESECSAPG 997
Query: 402 DDGNVIRCAEQRFTNTVQGLMILGTMTRPFLI--CLGLIPQAVLSGLFFIMGIQGLVSNT 459
+ + EQR T GLMI M + L IP VL G+F MG+ L
Sbjct: 998 EQPKFLGIREQRVT----GLMIFILMGLSVFMTSVLKFIPMPVLYGVFLYMGVSSLKGIQ 1053
Query: 460 IVHRIWFVFTDPKKKSKDST-LNTVSTKSLLLFISLSLVGFVAEFAITNTKGAIGFPIVL 518
+ RI +F P K D L V + +F + L V + I + A+ FP+++
Sbjct: 1054 LFDRI-KLFGMPAKHQPDLIYLRYVPLWKVHIFTVIQLTCLVLLWVIKVSAAAVVFPMMV 1112
Query: 519 LLTVILSLFFPKIFPDKDLAILDEPVSE 546
L V + F ++L+ LD+ + E
Sbjct: 1113 LALVFVRKLMDLCFTKRELSWLDDLMPE 1140
>Hs4759134 [P] KOG1172 Na+-independent Cl/HCO3 exchanger AE1 and related
transporters (SLC4 family)
Length = 1044
Score = 84.7 bits (208), Expect = 3e-16
Identities = 85/319 (26%), Positives = 138/319 (42%), Gaps = 29/319 (9%)
Query: 242 IFGLAFKFFQLTPLLTYTMRTLISDYSTALSVVFWSGFIHFGGLLDSVSFQKLPITKAFA 301
I K F+ + +R+++SD++ L++ F I F L V KL + F
Sbjct: 707 ILSSTLKTFKTSRYFPTRVRSMVSDFAVFLTI-FTMVIIDF---LIGVPSPKLQVPSVFK 762
Query: 302 PTRHGDSRQTWLAYQDISVGD-----VFLALPFGIVLTILFYFDHNVSSLMAQRKEYKLR 356
PTR D R W+ +G V A+ ++ TIL + D +++++ RKE+KL+
Sbjct: 763 PTR--DDRG-WIINP---IGPNPWWTVIAAIIPALLCTILIFMDQQITAVIINRKEHKLK 816
Query: 357 KASTFHYDFALLGITTGIAGVLGIPAPNGLIPQAPLHTQSLLVRD------DDGNVIRCA 410
K +H D ++ I G+ ++G+P + H SL + + +
Sbjct: 817 KGCGYHLDLLMVAIMLGVCSIMGLPWFVAATVLSITHVNSLKLESECSAPGEQPKFLGIR 876
Query: 411 EQRFTNTVQGLMILGTMTRPFLI--CLGLIPQAVLSGLFFIMGIQGLVSNTIVHRIWFVF 468
EQR T GLMI M + L IP VL G+F MG+ L R+ +F
Sbjct: 877 EQRVT----GLMIFVLMGCSVFMTAILKFIPMPVLYGVFLYMGVSSLQGIQFFDRL-KLF 931
Query: 469 TDPKKKSKDST-LNTVSTKSLLLFISLSLVGFVAEFAITNTKGAIGFPIVLLLTVILSLF 527
P K D L V + + LF + L V + I + AI FP+++L V +
Sbjct: 932 GMPAKHQPDFIYLRHVPLRKVHLFTLIQLTCLVLLWVIKASPAAIVFPMMVLALVFVRKV 991
Query: 528 FPKIFPDKDLAILDEPVSE 546
F ++L+ LD+ E
Sbjct: 992 MDLCFSKRELSWLDDLTPE 1010
Score = 83.2 bits (204), Expect = 1e-15
Identities = 44/163 (26%), Positives = 81/163 (48%)
Query: 52 LCAGLIHDIKDKVPQYPSDWKDSWDYRVIPSVLETYFNNLLPALAFAQDMFDRTDNSYGV 111
L GL+ DIK K P Y SD++D+ + + S L Y + P + F + + T+
Sbjct: 451 LFGGLVLDIKRKAPWYWSDYRDALSLQCLASFLFLYCACMSPVITFGGLLGEATEGRISA 510
Query: 112 NEVLLSSAIAGLVFGIIGGQPLCIVGVTGPISIFNYTVYEIIMPLNIDYFGFMFWICIWS 171
E L +++ G+ + + GQ L I+G TGP+ +F +++ + Y I +W+
Sbjct: 511 IESLFGASMTGIAYSLFAGQALTILGSTGPVLVFEKILFKFCKDYALSYLSLRACIGLWT 570
Query: 172 MITHFLLVIVNSVCLLQYVTTFPCDIFGLFINVVYIQKGIQIL 214
+LV ++ L+ Y+T F + F I +++I + I+ L
Sbjct: 571 AFLCIVLVATDASSLVCYITRFTEEAFASLICIIFIYEAIEKL 613
Database: KOG eukaryal database 04/03
Posted date: Apr 14, 2003 1:07 PM
Number of letters in database: 30,389,216
Number of sequences in database: 60,738
Lambda K H
0.327 0.143 0.434
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,586,723
Number of Sequences: 60738
Number of extensions: 1388280
Number of successful extensions: 4265
Number of sequences better than 1.0e-05: 29
Number of HSP's better than 0.0 without gapping: 29
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 4143
Number of HSP's gapped (non-prelim): 57
length of query: 559
length of database: 30,389,216
effective HSP length: 112
effective length of query: 447
effective length of database: 23,586,560
effective search space: 10543192320
effective search space used: 10543192320
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)